<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9G5</accession>
    <name>A0AA38K9G5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_358559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793386">
        <property type="protein sequence ID" value="KAJ3784194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9G5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="75"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3784194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="186" mass="21049" checksum="4B442AA21ABF68FD" modified="2024-01-24" version="1">MSLPQSLRTSVTPPELELIASQQLIEIIPLIAVEKTAFISGAFGPLQPPRKAQIPLWMAINLKLKKKCHIVAPEWLSVEFLQSRLDEEINEPGFSKLPFRYAEVSKLLLDVAPDDIQSTDKIRYLLKDLREARQAKSREGVDQINRGELSLSNLCSMEINEIRPFFVHAMGILTHLHRDASAEDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAG9</accession>
    <name>A0AA38KAG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_352547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAG9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="151" mass="17332" checksum="393F7AAEBCD4D4B1" modified="2024-01-24" version="1">MSKKALVDIAFYLNVPSKDVRQDALCVHLQAHFDAHEELKKHLRYIGIFERMRKRKDPPSGSNPGPSSLIPGLFHSHRVRLRLHQDHHCIRCPCITHPSPLHPFLVDSVTIMRTGHTHCMEHLISNSHYSLNGMLHTEHIVVNTTINATYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAR2</accession>
    <name>A0AA38KAR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_165365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAR2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="223" mass="24854" checksum="B6A5FED02F4F8D5F" modified="2024-01-24" version="1">MRLVSILNVAIVFGLFTTVFTMPVFLHDTIQLRSDESRVGLLPRKQEPPKSFQFIEGSEALHQPGPQAQAPSPPRRGAAGPPEPRPQQTTTETQTTSTVKITFIPGAETAVNEVIREETERTVKLGLTQTTAAFDPRRRHGQTFEFTNFFPGNALAQRQIIHFKVDDPWQAGQCGSGCLGSAAFVDNLGGPRSYHARVRQLDEDEEEPYERYPRVSLPRPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB04</accession>
    <name>A0AA38KB04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_309595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="342"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="640" mass="71973" checksum="EE94CACEA3A73301" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBY2</accession>
    <name>A0AA38KBY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_262733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBY2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23534" checksum="1503AC786951CF35" modified="2024-01-24" version="1" fragment="single">GCTQKTDLVLESQDGVRFGAHSANLAAFSDAFPVVDSGINANEVVQMTERADVVLLLLQLTHRQRWMRSDKIPFGLLHRLAEAAEKFFIPAIMEMCRIQMETVASKHPLEVFIYACKHSYDDIRDAAAPGTLDLPFESTLRRLSAYPSTCISWVCTYSFSAEDEIFTYIIRSRSAIVMWRHLCNSIVVTRILSTTSAFIGKSFGVDLSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCY4</accession>
    <name>A0AA38KCY4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794035">
        <property type="protein sequence ID" value="KAJ3779951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCY4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="249" mass="27493" checksum="4186D442F1F81025" modified="2024-01-24" version="1">MASIAAIHHFSHPWFDKPSMKRRHSSSSPEDEAPLNVSPTSAKRRRVTALERGFSNLSLHHVQPGASTSTSFIAPTSYPDSGSIPPPSYLIHTTALSSSSPPLSDTLTAMEVEYSSMTPSIQPDSVEEPPSPSLLLPEIQMKKSSSWYEPEPDRIVVTDLDSSDDEDEAELVNPVVSPTLLERIRQRELFNTVPVPSLPNQQALVLYRPLTRPSTYTEPEDDQLDISPDQEIVLDASSSVQDVEMMDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD28</accession>
    <name>A0AA38KD28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_317862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793449">
        <property type="protein sequence ID" value="KAJ3782863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD28"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="406" mass="42865" checksum="F046D0866B9F8ED3" modified="2024-01-24" version="1">MGGRDLELDCPDGGLRAWLVVLGVSLAFPSCLGYMTSWGVFQSYYEQTLLKDHTPSSIAWIGSLQLCLVFLPGLVSGRLFDLGIFKLPFVAASALLVTATFLVGECTQYWQFVLCQGLATGLGVGMIFGPSLSVLGHWFKRKRGAAMGLTAVGSSVGGTVLPIATRKLIPAVGFTWTMRILAFILLFSLSVPCFTLARRLPPKTVSGGLFNFRAFRDSPPFTVYCTGVVFLFLGLFTVLTYIDISAVTNGVSPNYTFYLVSITNASSTVGRIVTGLVVDKSGAINFIAPTTFLAGIITFAWPFATSGSSLTAIAVLYGFTSGTVISGLVIPVFLLGDVSDIGRRTGMVMSLGALGGLFGAPISGAINKASGGFEDVGCFAGSMLIIAGIFMLATRHLVLGKFSGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDS6</accession>
    <name>A0AA38KDS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heat shock protein 9/12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_359100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDS6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8267" checksum="41E776F100E44DC6" modified="2024-01-24" version="1">MSDNARESFTSKTKAAVVPDSEKSTSTHLKDKAKGNADDAASAVQPEKSNTQKAGDAISGNNSESLLDKTKDTLGLNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEQ2</accession>
    <name>A0AA38KEQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitin synthase III catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_436199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793438">
        <property type="protein sequence ID" value="KAJ3783071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEQ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="33370" checksum="F3802A2EBFE702C9" modified="2024-01-24" version="1">MSRFGDFGDICTNVPSYTWCNLFYRQLSETSNLSSILTGVSSNPTSAPVGVNPSCGIPRVGSNGSVGNIGNIVVCALSMIVVIALISLTERRKAAVGRVELRNLLVMYFITLPFQLITNGSLLEQGSTVLVVLTAIHAALVATLFWALLANALVSTQVVEDGTMASLAPFYILSFLIFGGTLYIALDVALGITQTLGPSSNPKELLSIPLFIMTSFWPLLAAILYLSIMLYIILAMLKESRPTLYYILAGVAFVFSQLAWFLLGKVICVGSGSKLDGSFLATILETITVVLIFFGWKSITEGAWDETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KET5</accession>
    <name>A0AA38KET5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_405219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793432">
        <property type="protein sequence ID" value="KAJ3783176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KET5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="166" mass="18343" checksum="F7CA37FC9A00BB37" modified="2024-01-24" version="1">MPMPIMKNISQQTVVKKSSHPTIQERKIVYEGSASPRELLEAIALQAQAALKGLETSRAPDDLPPESSEEQKRKVVVVIKGKPKEDKLPDSLDKTVKLYSFCNRLLATTAQIDRSLRELKGEDFVNRNGCKFVLGGHDGRILTASASALLYFRTRPLGGITLSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF13</accession>
    <name>A0AA38KF13_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_311919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3785998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF13"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000009">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF117">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041385404" evidence="4">
        <location>
            <begin position="16"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="730"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="811" mass="87744" checksum="BB08692E19AD9512" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFW3</accession>
    <name>A0AA38KFW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF427-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_19415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFW3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF5">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="94" mass="10624" checksum="DEA8D303F00FBFDC" modified="2024-01-24" version="1">MKAILNGVVLAESEETKVIEGNHYFPPESVKKDYFTDSDTSSVCSWKGTCSYYDATVSGKKVPDVAWYYPSTISDRAKPIENYVAFYKSKVEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFY8</accession>
    <name>A0AA38KFY8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_348687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFY8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="93" mass="10334" checksum="CED71C18FA48E270" modified="2024-01-24" version="1">MSNAIQDYFEGKIDFVGQQRVDEIARIWLFSFTALSFALGFALHSLKTSFMLLGSSTVVLCAIVLPAWPMYNKHPVKWLPALKPSGGETNKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGE7</accession>
    <name>A0AA38KGE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_307610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGE7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="291" mass="32121" checksum="3B5DBA7D2DDFF9E2" modified="2024-01-24" version="1">MNTGATRNVALIFGYVPNQTAAIIAAAFYFCFGTALSLHIVRLKNWWALALPIGTLGSGLGFITRYILAEPAYQTSKTTMIVEEVLTLCFPAGFLAFNYIVYGRLVLYCVGARHSLIRPQWVSTFFIMSDVSTFVIQGIGAAFVVQPEHHDLGGKIVEVGVILQTISFGIFSAMLLLTYVSVRRERSTNGTETWWRAYQAVAFSSTFIVIRSIYRMISSIDGSSSVIATTEIYLYLLDVLPLMIAIGVYIPFWPGSYTTGEDSILHIAIPEQHKLSSFDAGSRELLASHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGG4</accession>
    <name>A0AA38KGG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_434288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGG4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="300" mass="33878" checksum="76F8FB1D3C85D4D6" modified="2024-01-24" version="1">MDLTTSVSIISFTLLYYDYFLTLGEEVNLFWSYRSLTWVTIMFYVTRYFSILGSIPVMFGHFWLGHVAVCLSLQTYHQYYALILQVFIGVLLLLRTYALYERNFKVLVLLVVVGLALLIFGIALLVWGRNEIQLQETVVVSNELGCQLWLNQQNASCLALVWGGMLLFDFLVFSLTLYKALTLQRDGRVTLLSVLMRDGTVYFGVMAISIIANILTFMHLPHELDDLSVGHRAFAPLLGQPETRGMATTFTNSISSIMISRLMFNLRDPGLSRILPSLRSPALPHAAVATLDSLQEEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH87</accession>
    <name>A0AA38KH87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_374312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="354" mass="39133" checksum="D5B30D01AE5AB109" modified="2024-01-24" version="1">MAPKRRKQANPEAEWGVGRNTTTLSDNSGNVVASSSSQTSTSVENRGMSVSPEPQAAPLRSPTGEGEIRPFSNENRSAANRQEDDVSSSNSTVSPRKTAESSKGKARIPPTGGEDENTSSSPPLTVSDLARMPETAMSLARVVQKRMRDMVQGINDDAEDFRANAEYCMQEGFNELNALIAEHVPSLELDAQGNLVPKATDRIDNPASMMDPIDVESPTDNTKNREYILYVPPAKRVPKSEDTQSRPMSTLQYRRFVGRKLSAPCSINSRASVSVGSGRHVLCQAREGVTRSDILIGKRITHRAFGSIQPPVIPPMDLLNRLLDRRIDRHFLLGRWPCCWYRGWISLYLKVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI29</accession>
    <name>A0AA38KI29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_92906</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="28"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="651"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3788786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="866" mass="95255" checksum="E7392CD16F165B92" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI69</accession>
    <name>A0AA38KI69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_261555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI69"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="53129" checksum="C77CE3FC41DF9664" modified="2024-01-24" version="1">MQLDNIAPPKRRKLNPDQIQSAFADITQHLKSAKSKPHAGSEGLEARRARAIQSTLHSMVNNRSSFVYASCIAAEAAMFAKDWGSRLVRRWVRDWINVRSLPQSNRGRHSKINSVLSDSTAREAIRTYLRSNKWALNPQKLEQLMKGELVSEEASEYRREIEHNEMPRGLKVFIEEKVLPRLHVKPASSLGLSLSSMRCNLVLVAHDEMVAQAHDGLKYTWVLNGEQPLRKKGVGRGLHQSDFICSTVGWLEKASVTIEYGKNHDGMWTGELFAKQIQEKFFKAFADAHGPGHIAVILVDNSQGHSSYAPDALRASGMNLKPGGKQARMHAGWYMRDGQKIIQPMIYGPDHEMYSNQAKGMKAVLQERGLWQGNLLGTCKKKLKRWLREHCDYTFSTLQKNMQRALRSVPVQVIRKWEHRTWRFIDAYAANLDAKDALLKVKQFSSQKYKSHRRVPERLVQAMDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KK62</accession>
    <name>A0AA38KK62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bola protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_370339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794390">
        <property type="protein sequence ID" value="KAJ3779684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KK62"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="84" mass="9319" checksum="59FA465B0F1F167E" modified="2024-01-24" version="1">MINLADLEAAIRNALPVSHLEIQDQSSGCGESYAIVLVSEAFEGKGTLARHRFVNDLLKDQIAQMHAFSQKTFTPKQYQDLVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKZ5</accession>
    <name>A0AA38KKZ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_368113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793619">
        <property type="protein sequence ID" value="KAJ3780974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKZ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="264" mass="30016" checksum="B60ECE17B8EC655C" modified="2024-01-24" version="1">MMDGNLRQLKRSSEFFLTGGDLHLIVNEYRFRVHSYFFTRESQHFRQRLAISDAFDLQGNGSSMSSAIVLDDYDITPEEFESFLKVFYNPRYSFYDLAHPYEEWASILKLSNLWDFPNVKELAINELERLDIPLVDRIVLYQDNQVDADLRLPLYIQLASREATLDHDESTRLGFRTAIVIFQARERLRSLATGGKSPLPDEVGEDAAKEVVCNLFKAVPPLGEATPPATPKPRIINGFDSPRRTSSGFGFGTHSRTPSSSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KME1</accession>
    <name>A0AA38KME1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794548">
        <property type="protein sequence ID" value="KAJ3779601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KME1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="101" mass="11334" checksum="E10603B5329C8FC0" modified="2024-01-24" version="1">MNRTITAIKRIKEIIYKMETRWSANDQSKDVKGQTDTKADSSNHVIAQYPQPAQTIPKQPKFPLKPPKPIIGPKNYVPVQKQTLGAPPKDDNQNLEGGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMM9</accession>
    <name>A0AA38KMM9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794095">
        <property type="protein sequence ID" value="KAJ3779886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMM9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="325" mass="36144" checksum="2ED1AE02E152AC92" modified="2024-01-24" version="1" fragment="single">MSSDTRLASKSSLENPSIPNLPKSRPYTIPPLTLPTVNLLSDVVHESAQTIAWPCGWETVLPTAIQDGVNVLEPDAEHVRWMADSRNAIPSEHSNVKYLDKAAYGKKNKGALIDDIRKLNGQNYVVVISGHVDDHGKKFESYEDVEEEYSLAVDKSLDLQYHSSWAQDEPTGYHTPTMVLGFIENVNNTDVIGMILDTPICKQGLPEPYNQMDDSAIAVQQMKSSQSVKLVGLNLAIHLQHLLSPTWACFTMQDADGFSVAGQVLGDRNDPQPKMWALISFKDPSVAAQAHEKIAQTILDLCIYQNDIAKDNKNGQFWDDGIWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMX1</accession>
    <name>A0AA38KMX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_381066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793873">
        <property type="protein sequence ID" value="KAJ3780171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="271" mass="31178" checksum="3C02C6C9662BDF92" modified="2024-01-24" version="1">MYTNHSSFHSLHSSSSSFHIFPPCTTNSDTSQRILRLGFPLKRSNTPDEHGFHPWEEYHSQEPYSIPFLHPSTLEHGRTDAFVDVTRIVSTFPRDMCLRWVFQDPDSGDIRVLYGRDSELRWSEVIAGVRSGIVPARYVNKEVDGITQHGPMTREWFMDMCSLFTVSADGKLLREGLEICRIWEDFEWTAIVVLPTKKEVNLALYTPERLVNDVRRESGMWHLDSHHRAYALLERFNSIAPRNSVTSSSSPFSQIHIPITVPPPPYAMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMY3</accession>
    <name>A0AA38KMY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_162070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793858">
        <property type="protein sequence ID" value="KAJ3780201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041251647" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="165" mass="18548" checksum="B004B65E6636F15C" modified="2024-01-24" version="1">MQSKVYFVILFELLCAVYYTAAQPVPVSEVAPPPQVDPRAPWIALVKFHHCCTKQLDAETESMIQFRIKKKIQVEAARGTSLPVLFEKTGVPDFLNDEIGFDVTWSSAKHSYTTEGQVVITQRSRRTPYWIIKLATVPPEVHTPERDAKTPAISINGVLVHNSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMY8</accession>
    <name>A0AA38KMY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793851">
        <property type="protein sequence ID" value="KAJ3780216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMY8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="204" mass="23064" checksum="274CDF8B0218BB9D" modified="2024-01-24" version="1">MEYKVTLQEHQARNPSLRPTSPNTVFAATSVNFGPRTETHPHCDAGNLAHGWCAIIALGDYNPNEGGHLLLWDLGLIIRFPPGSTILFPSALITHSNVPIQPYETRYSIVQYSGGGLLHWRNNRWCSDKTLLENSTAAQWKMQEDNNKRRWSVSLQKFTWWSDLVSGDWKGKVQTAAGLDELSELSNDKSNDEIDLPPKKHTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNG7</accession>
    <name>A0AA38KNG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NO signaling/Golgi transport ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_429060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793423">
        <property type="protein sequence ID" value="KAJ3783360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="249" mass="27253" checksum="DB9C311779DC1CFF" modified="2024-01-24" version="1">MASRNSLQVPSSSSSVPPHLAALAAFADPPIRHVDGAMMDYFLIETVNILRESSKVALNREREREKEMVEAGLIPPPAPPVKDIKDPLASARDSTGSLTLTKAGKAAAAGPVDDEEEELKLRLETIGIHVGSNFSERLCRDRGLFTETLDAIKFICKDIWAACWDKQVDNLRTNHRGVYVLQDNSFKTISRLSSWQGRPDAVRKAKVYVSMPAGIIKGALARLGYNATVSPEITNLPQCTFQVKLPKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNK8</accession>
    <name>A0AA38KNK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_358372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793383">
        <property type="protein sequence ID" value="KAJ3784274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNK8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="387" mass="41759" checksum="4127A771DCC12C9B" modified="2024-01-24" version="1">MPVPGRGPRSSGSRRASKARPVTSTGYEGAGNPDVMYPGLSQSKLDRNDFSASFSYRKKEKEEDVGFVHKLSNENRQFDNARRFQPQPQPYNNYSHDSQYGVYSSEHSSTTPTPIPMASYSSAYPHHYHSVSSGGPPPPIVPSSSPSISSSSPSQSPIQDFHEPEFESSTFNSTEGNFPYIASHISFGSASSSAPYLPLSSINSLNTKTLSGPGGRHPTPTRLSSRTSHPHLNDLHSYHSSNGPMQGIRHGGRSPHPRSPFRPSPLSGHPTGASPGSYFPLVPSNADAMDMDMDRQHRQHQSQLRSPSTRSQSSTSLPGTPFDEGGPGGYLTATTTTNGVQEMNGNGYFSNQQQRQRVPSVPSVSMQTQGGYTTLSYGAEISAGYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNP8</accession>
    <name>A0AA38KNP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_437557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793613">
        <property type="protein sequence ID" value="KAJ3781026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNP8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36538" checksum="1F829773CA4BC168" modified="2024-01-24" version="1">MGVIPDEALTEYYERVRGKTVIITGAGASIGRATAILFASYGAKVVVADKNVSSAEDTVSEIRSNEGEATSCRCDVTVWEDLVAMYDLAVQEFGSVDIVVANAGVGEIGGRMLDDFSKERPTKPLTTTIDVNLTGVLYTVYLAQHYLQLNRPQEDRTSRSSSLKAVVLVGSIASWTALTQAPMYTASKHAVLGMMRSLDASFASRGLRIASIHPFFAATSIVPGIVRLQLAGIPLAPVPRIAGVIFYAASHPDPTCSGAAFWIPDGGAPTFIIPRKEFKPGVYEYIDSKSNAASKGLTGPRYYVRRIRTLTHLLWKELAVLCILAMFVGCSVSILTGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPB2</accession>
    <name>A0AA38KPB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793385">
        <property type="protein sequence ID" value="KAJ3784230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="431" mass="48419" checksum="57C961332B6B4A81" modified="2024-01-24" version="1">MQTASKRLRSKVDLSDAYEQIRVVEENTWKNAFASVSGTFVSREPKIEETLYIPPPPPIDSYTHDWYTNKRGRRGAPPGNRHGGTGRSHPYTPHRTLLNAGDLHNSSILTERTISTTVKTSPKRNLTLRYIPHIGSIDPEPFEDGEEQFVAIRNLHYRPGHGPGPGFIWDININGKLKRTEVDLDHEATIWARRSNQCQHQGYSHEKRETTRAMNIQHGKPSVTATPKAISLRRLLEWESGMSGTVTVAEGIVEAEFSLPSWAKHSIFMDGHPVITLVAVHGTIIDHPGIFITDSGFIDLDTVVGHCLLRALNYAPSSESSSFKELFITLLTLPKCYSQVVDVHRLNITPTTQPMACPYEPKTIVDVARHMANCGITESQADSLLQYARFFCIDKLQSKLRRTKPVHGSEYFVDLIYACWSQIAYLNATPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPV8</accession>
    <name>A0AA38KPV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_312288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="219" mass="24825" checksum="740A93521A25F4BA" modified="2024-01-24" version="1">MLTVHHLNNSRSQRILWLLEELEVPYEIKKYHRLPSMLAPPELLAVNPLGKAPVITDGEINIAESGAIIEYIIEKYGQGKISTTLEGAIDDLYFLHYAEGTLMPILVQKLIFSLIPARSPWLIRWFLKIIFDELARKIVEPELKKNVDMIESHLVKKDWLAGGSGPTAADFSMSMCLEILKQEKIAHPATVAYVKRLQARPAYRRALMKGGDYSYGPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ71</accession>
    <name>A0AA38KQ71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_355515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793349">
        <property type="protein sequence ID" value="KAJ3785205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="538" mass="59473" checksum="DC82A2F4B42D289D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ87</accession>
    <name>A0AA38KQ87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein transporter SEC9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_69421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793447">
        <property type="protein sequence ID" value="KAJ3782901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="327"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="389" mass="43348" checksum="682BEC18FDD1AA7C" modified="2024-01-24" version="1">MPLFKKNKNLIPPVESSVSSSSPRSKSPSVLSKSSLPSYRSNASTYVASRDGDPYSANESVPPSSNIPDQASYDDSGPSYADRYRRGNAVGDVYSRGGAQLDQDRSELFAGFNPQKSGSGRFFDGPGAGRDPAPGEENDEDVEGIKTQTRFIKQESVNSTRNALMMARQAEETARGTLSKLGDQSESLANTERHLDLAKSHGQRAEDKTDELKQLNRSIFRPVITFNKDAKRRAQEAKIQDRYEEERLERERTMMDVRETQNRLGRAATYGRGNDDENLLYNGPPGGTAEESIAGGGSGRFRKSEQQRTRNREMNSRYRFEATASDDELEDELDENLDEISDVTKRLKALGTAMSQELDTQNSRIDNITSKTDGVDMKLANLTRRQKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQJ4</accession>
    <name>A0AA38KQJ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_266712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQJ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17925" checksum="753F31E70373A47D" modified="2024-01-24" version="1">MNARRTSLTPSLSERGFLPRNCHATVDSVLKDLKLYSRRLSTMTIALAEESQILDRLHYKNKNQHRSSLFIRRLNELRRYSRRTEEFQICSFVNDLRQSFFGKADGSRQKQMKGAWSHHPDEEYVSKVKEQSSCFLSLLRKASYIFPNCTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQP0</accession>
    <name>A0AA38KQP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_312246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQP0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="401"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="508" mass="53662" checksum="5AEC5A8A1C2999C6" modified="2024-01-24" version="1">MVSVPLGAFSNTSSVSPSHISFSIEQDRWTDWAGTTAKNEFVLNALSNLASFTGQPPRFRIGADSEDRTNFQPGLNLAELSFSPPSAATPYPEASSVIVGEAFYLAAQNLLPGTHVTWGVNFKSLNLTAAFLEAGAIADAFNSFPASSRLVLDAIEIGNEADLYTSNGGRPANFTIVQYVPQWTSFASNVSATVPIGANTITKFWGGAFAGSDHSTNGFSPQGLFNNGILATAPGMLIDTISQHVYSGSGLGCGSIGDCIQDMLSKNFIRGNLSQFIPDIAATKAQNLTYVLGETNSYFNHGSANVSDSAGAALWALDYAFFASSLGIERLYFHEGVGYKYNFIQPVTLNTSINDGTPLPEPLPPHIQPAYYGAIVAAEAIGKAGGTSVSELSLDSDTMSGYAFYSSDGQLSKTLFINSEGFFTSSGNNRTSIHLDLDFTGTGQSPSRMTVKRLEIGHADDTSGLTWGGQTYETSDALVSGMLSVETINIGDGLDIPATQAILVTFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRF3</accession>
    <name>A0AA38KRF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rec8 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_357883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793377">
        <property type="protein sequence ID" value="KAJ3784431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="591"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="686" mass="74780" checksum="5F130FD74D67EDC9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRM7</accession>
    <name>A0AA38KRM7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_350312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21370" checksum="90F136C56780804A" modified="2024-01-24" version="1">MLSCSASSNRISAKQLRNVKLGERLRFRSSNLIMKVFNTVNNAAIGEAKALNAVGDLVASGTVKALGLKPAIIMRKKPGQPLYETQAYKAAREIVREKMRNQTYGLMCNEISTVATKTYVLHDDNNPANILVTMDGNTVKSIALVDYGPPQTYFVGKSVTKADVSKYCGCEYPSSKRYVWEHEFPYVTPPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRY5</accession>
    <name>A0AA38KRY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adaptin ear-binding coat-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_309231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRY5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="23428" checksum="0444A9AFE3B9EB9B" modified="2024-01-24" version="1">MNISVEDDIESVLHVAREVSVFKIPPLKTNEGHRAGEWGDLAQPLWKGRLRILEKSSGVSILFEDGTTGELFAKADYDPANPCVEAVLDSSRYFVVRIEDNGRKAYIGMGFIERTDSFDFNVALQDHTKRWRASQNSSEPIEGEDKPSPHIPAGPKKDFSLKEGQTFSIAIPGKKKAATETSTDLFGISSASSVSGASGGGVPLLPPPPSSGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSL0</accession>
    <name>A0AA38KSL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_76032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSL0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="322" mass="36368" checksum="AF329A8DA01C0677" modified="2024-01-24" version="1">MDVQDESKEEMEEVESLAISRDQPTPIPRNQSLEEGNSHQGTVEASIDVEDEVSRSSQAPNPNTYEWKVEPEQDQMEAADEEGVTSGDEPLQRARRAKAAKRQRKASTPLPTRKGRRSRRTPVLDAETALETADNISEEVAQTPGTIDGEASPAPDDILFKRQSKRRASFSDDNPRESRRIRADSELADDEDGPPSSSRSRRQDNQASKRFQNVIGMLHSQISAHRNGAIFHNPIKNSEAPDYHEIVKRPMDLKTIKSKIKDGAISNSLEFQRDIYLMFANAMMYNRPGSDVYNMTEDMMLESEGYIQTFRHSEGFVRGSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KST7</accession>
    <name>A0AA38KST7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_311655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KST7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="338" mass="38940" checksum="A7B96573A6DB2D07" modified="2024-01-24" version="1">MTSLRNSIHRRNHKERSQLAHRAKLGFLEKHKDYVKRAKDYHSKQDRLTRLKQKAAERNKDEFYFSMTKERTKGGIHVKDRGNTALPTDVVKVLKTQDENYIRTMRVAGLKKIDKIKAQLTALADLVPAEDSEENSLNPEELEILKEAGLISSQSKKGSKRHIIFVDDDQVGLTGIHIFLARNYVGPSHDSRPDAMNVEAQDQSVDLGWIGPNEKRRSKKRQSAPDDDDAKGYSDIAEEIEGSAQQHRQRLLKELSARLVRDKQMRYAEREFEMQRLMMGKGARKKISAPERVGDDDNSDEDEDALDARGGRSRKTSATKSDETYKPRVYKWRIERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTL5</accession>
    <name>A0AA38KTL5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_386018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTL5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="109"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="369" mass="41904" checksum="C589081661896F38" modified="2024-01-24" version="1">MTLRERRPWSPEEDDLLRAAVLKEEPGNLNPSKWFAISTHVPGRTNKDCRKRWFARMAADIVRGVWSADEDAKLLSAVEKYGTKWSLVATMVHTRNSDQCAKRWTDTLDPTIDRSGWTPEQDHTLLDAVNEHGTCWKKIVKTYFPGKTGLSAKNRYTSLTRIQNSSRPIRRSQSTDDDTSSTSSDRHTPFYTPPTKHARAHSKPSWSHSPYPRRASSSTGSSSTEEHYNDVNQHFPYNGYQPADPFYPADSSDYWSTAMQLTQIQPQGLTQYPASSQSRLDEVDASYYLYDNTYSSMAVSPACHQRQIAPFCDPTSYVPSNTFTTSTFGSQLFPYDHRPLREDISAAGHFPTRLEHPFEGDHGADWGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTX3</accession>
    <name>A0AA38KTX3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 78 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_308428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041422190" evidence="1">
        <location>
            <begin position="23"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="679" mass="72558" checksum="363B313B7F154FF8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTZ5</accession>
    <name>A0AA38KTZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADK-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_393758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTZ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="328" mass="36740" checksum="2DCCD177EECE338F" modified="2024-01-24" version="1">MSIRTRPNPRLSAWSAAARSIASSSPASLFRNSLQPVAHDEAQSDSRNVRMLRMIMFGKPGAGKGTLSGRLVKKYDILSLSTGDLLRMHIQDKTEIGRMAKEIVAHGGLVPDELMLQVVTSKLDHLHNKHWILDGFPRTLAQGELLNTHLNKQNTPLSLVVNLDVPDDIILSRISDRWVHLPSGRVYNLSYNPPKVEGFDDETGEPLTKRPDDNPEIFARRLEKFYSTTSPLLDFYARLSQTRISPPPHRHPHQHPHQLAFHTKPPHRLMVQSISGTTSDEIWPQLETVLKEAFPGLKERVDSADIRRRHSLSDAIAAASVAASMPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUE8</accession>
    <name>A0AA38KUE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribophorin II</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_306971</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SWP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUE8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044310633" description="Ribophorin II" evidence="13">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II third" evidence="14">
        <location>
            <begin position="34"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="15">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3788496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="276" mass="29903" checksum="B6E4924A7441556B" modified="2024-01-24" version="1">MKKAAFLLFLATAAHAAKLSADSVKYSIISAKGEPSTKSLVPTEKPSSEVVTLSEDQTLKLSLQVVDQATGKGVQPEQAFLRFYDEQSGEEGIQPIRVTSSGKAKFDLSMAKPPASLPPTSTAPLKVTLLLGSSSHSPQKLELFNLHVPASHPAPVHPDEVKFHLLPELAHTFRPDPKLPPRAVSAFFTGIILVVPWSILLGLWFSVSPQVPRLFSPNILPFTASLGAFEFLLYRYWVDLKLGDVLTYGAVLGVVTVFTGRHALASIADRRLGSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUI1</accession>
    <name>A0AA38KUI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_306721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="157" mass="17877" checksum="7E56C1DCCADDA2F0" modified="2024-01-24" version="1">MLGASRLMARQRVYTPLIRQRYASTSHGDHHGHHHIEEDTTVYPKEGFATPAWRRFFVVSIIAGAVYQFAPNPSEEAFITRWLAMYTTTSEKWLDMNVRHTALSKNAAEGVNLLTTASRPPIHRMRFPQMMDNASPFNVPVGLNADTHDFVAKTEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUN0</accession>
    <name>A0AA38KUN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pectin lyase fold/virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_298009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793480">
        <property type="protein sequence ID" value="KAJ3782367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="424" mass="45264" checksum="BA44C222012E4ADC" modified="2024-01-24" version="1">MDTPSISFQMARLLLRILGFQCFFAYFNPALSGYVQRTGPTCTVSASPNGTDDAPAIMDAFQMCGINGIIHLHDPVYHIETVMNTTGLSNVQIDLTGTMLWGTNLSYWIASGLPLGYQNATTAWALGGDQILFDGHGVGTLDGNGQLWYNLADGVSNYPGRPINLLIANSTNSVYTGIRFVQSQYWTMAIKDSEDILLEGIYVNSTSNNTVPARNTDGVDTFFSNRITFRNWTVVNGDDCISMKANSTNILIQDSIFHGGLGVSIGSIGQYNGVFEMIQNVTAERVLAIGSRYGGYIKTWTGISQGFPPNGGGGGLGFATNITFRDFKLQNVTDNVALITQCTSFEGATGGCDTSLFQLSNITWGPGMVGSIQTDTLATMQCSGNAPCSGISLLGFDDVVTVGAPEIKCSNVTDPIGFNCTGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWM7</accession>
    <name>A0AA38KWM7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">GGU10DRAFT_290711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="334" mass="37435" checksum="FE33F2B5CE1593A3" modified="2024-01-24" version="1">MRPILLQGHERSLTQIKYNRDGDLLFSCSKDHVINVWYTHNGERLGTYDGHNGTVWTVDVDSESRFFVSGSADNQLRLWNVATGKCLYTWEFPTAVKRVAFSEDDKQVVCITEQRMGYQCTIRVFNISRIGDGSKQSKEPAHIFNPIGSKATVCAFTSQPSIIFTGHESGKVALFNFKTGEEVDSNERAHSDVVTDLQMSPDKTYCITSSKDKSARIHDTKTLDVIKTFTTETPLNSAAIAPNKPYVLLGGGQEAMSVTTTSLRQGKFETRFWHKVFEEEVGRVKGHFGPINTIAVHPKGNSYASGGEDGFIRVHHFDESYFKTQPYGDLQIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX97</accession>
    <name>A0AA38KX97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_299285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793535">
        <property type="protein sequence ID" value="KAJ3781658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX97"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29324" checksum="288C82F93847FBCA" modified="2024-01-24" version="1">MSSLKHENKLIQRGSSSSPTPFSRSVFVFFRALDLPLQYSIISSRALAAPLIRELGGASIPPTGRPLYLLGTNTGLSPQRAILFGMAIGSVVKQSHWAMFISREPMPTGASAAVGVFNAFSNAINMILFTNAATSALAYPTVDGDETKLSVPTLVGLGMYALGMVLEWGSELQRLRFKKNPINKGRVYSGGLFGLARHINYGGYVLWRGGFALAAAGWTWGAIVGGFHIWNFVSSSIPELDEYCSNRYNEQWAQYKRAVPYKLFPFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY35</accession>
    <name>A0AA38KY35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_274613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793446">
        <property type="protein sequence ID" value="KAJ3782903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY35"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="217" mass="25093" checksum="F3939862B21606A2" modified="2024-01-24" version="1">MRQHIGHAMQNRSAAIVSALESYNEAAAKLSPPRKLLDWNNVLNYTYLSEFDFLRDTRSDVRDRPWAKPAVREAMSEFFKLIRAGEELDRLHIEIKRLLTSMKEEEEYIPAVARKVQAYNPPLAYQIQLYGNERGRFNAVHRMRLNSIRKLKGFNPIDSHFFQPGIGIRRQRVEEADFCETQAAREEDDDDESEGEDEEAEANDLAETVLAVANDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY70</accession>
    <name>A0AA38KY70_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_345470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY70"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="160" mass="17611" checksum="458600E5560736DD" modified="2024-01-24" version="1">MKIEWASDFHRDGSRRSRPIASTMHGWLAKMRGTLIGNEELRSRGMREMKDAKAFRRHRKVAKSKGKSSGKGFSLFGRKPTPQRTNSGNVTRGHYGGGGGSRPALRQHGSGSHRVVGQTPRRSSGTQSRGSKTPARPGPSRRTTTTSQRRGTTTRRSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0B2</accession>
    <name>A0AA38L0B2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_136805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0B2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="365" mass="39937" checksum="7CF0401A292F01AC" modified="2024-01-24" version="1">MMSEPTAVLLTGASGYLGGSLLVYLLHKFNLRSQNIKLFTLVRKAEQVGKVLELGGDVTPLVGDVQDAEGIKKLVIDNSVSVVLETVDARQFAVAKPFIEALTIVKERLNVPVHFIHTSGAKMFSSHVGVDQSTFLKDDGDVYATMARLDTRHPVMKQFVSLNNQIIDFAENNGVRSYIVAPPMVYGPGTGFGNKVSIQIVALVRVARALGQLYQVDNTDTIWPLMHIDDQVTLYVTVLSNLLRLQAPYGKNGIYFSENGTFGWRSLSLAVINALRNRNSIGIIHELPVATDEDLIAMGEVLDCNVGMVPVSLAGNCLIRGNNARKLGWAPQHDVEHLMSNVDNEVAFIVKEDSTFVPKAQLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0M3</accession>
    <name>A0AA38L0M3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxylic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_346065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0M3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="517" mass="56088" checksum="E51E9410FF84EE0E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1W2</accession>
    <name>A0AA38L1W2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cl-channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_278951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793674">
        <property type="protein sequence ID" value="KAJ3780682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1W2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000024">
        <property type="entry name" value="Voltage-gated chloride channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="754" mass="82497" checksum="2978B7171E58E05C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L200</accession>
    <name>A0AA38L200_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_278231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793608">
        <property type="protein sequence ID" value="KAJ3781072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L200"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="89"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3781072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="539" mass="59907" checksum="32B58D74B32861AA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2K2</accession>
    <name>A0AA38L2K2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_87739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793501">
        <property type="protein sequence ID" value="KAJ3782077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2K2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72482" checksum="9068435CECD784A1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3A4</accession>
    <name>A0AA38L3A4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_361360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="MU793427">
        <property type="protein sequence ID" value="KAJ3783277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3A4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="243"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1222" mass="130683" checksum="ECC4C7CFE3C4C657" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3M2</accession>
    <name>A0AA38L3M2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_42643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3M2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="20943" checksum="41E082CB9A17996E" modified="2024-01-24" version="1">MPLFGGHKHDKKHNTLHKDEQLATGTGAAGGLNNSTAGSGAYAAESNVPPSGGHSAHHHHQGMNNQQQGYPNQTIANDYGNSGMNTQPGMGGTGNNGYNDFSGNQPNIPPSSHLNASGGTGHSTTGKVEKAIGSAVGSNALKAKGMQKELEANALKTQSSELAEAERLEKEALLRRERAVAHGAHPDNRHLGGSDSQNTMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4N1</accession>
    <name>A0AA38L4N1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_421595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4N1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55002" checksum="ADA68E8C54701078" modified="2024-01-24" version="1">MATAAVLHSRSSIDSLRSIRSTATNRTTIHNRLQKALPTKDRDVWASNEGNKPQALPARFADLKKRLVKPEDYDAVRASWDRLLLALEQRVQVIKTAGPMAVPVVDFTEIQESNGQFPVEISDTIRAAGCCVVRGVVPRAQALEWKASLLSYVDRHPDIRRIPDDLEPQIYSTFWQKAQIEARSHPAVIRTQLAISQLYTASEDTEVDLVNQALYADRWRVRRPGSAGMFQPHLDNGSIERWEDEEYGRAFRKIWEGKWEEYDAWDMDHRAEAVMDLYGGPGACSAFRSLQGWLSIDDNGPQCGTIQLLPDIKLSTAYILLRPFFNDQNKLDMDSTYFYGADPGQGHVLKDIWHPHLHLDHTIVSCPKAAPGDYVLWHCDLVHKVEEQHKGVNNSSVIYIPVVPLCGYNVGNLVDQRKAFLEGIPPPDMPPVSSSEGLERDHEDRGKPDHIMTLAGRRLMGLEPFEVNEAGITAGQKTIREAANEALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L551</accession>
    <name>A0AA38L551_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_356858</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793364">
        <property type="protein sequence ID" value="KAJ3784765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L551"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="597" mass="68096" checksum="7F3A057F883CE401" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5H8</accession>
    <name>A0AA38L5H8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_4791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5H8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="338" mass="36758" checksum="CD59B16D194A157F" modified="2024-01-24" version="1">MAYQHSVNSFQTLQQDVVSGDQYRYALTNFRIAHEKVEEQRAQLEEQERQVAQLRARIALLEGNSAGIVGKSGNSVDDFSIKNAAAQLEKMINRWASDIVRNPPVSLIELCGAIMNDLASTVTDTPPRYDGSSIQVQSLLRHILSETISEGIINCLVVTNSPEANDQLTRIHEHIFMRDPTIASVWRRQTYSAAVDSCSPDMTASVLVEHMPTLLKCMDGALPTTGGKSIIDAAYDFSRMIHGSHASSGDAFYRAFVPELGSTLSPRQNELVKRCMSSEIGNIDRVGATVFPGLVKVSKGPAIPGQEAEIIQTVVRRAQVICECALTGGSVPSATVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6E1</accession>
    <name>A0AA38L6E1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_349305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6E1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="34659" checksum="00C543AAFF4C2EA4" modified="2024-01-24" version="1">MSTNHTVNSDQATFLGMVFEALAYGIYTLLFFTSLAVLTWRTPALNASKKPMFATTIFMFSLATVHFSLNFHNVYQGLMVNPRAHISDETHLLAGADMIFSISDFCSQLILIYRCYLVWSRNIWVVILPILISLASVSCGIALIGLVLTISPTAPQAPEAIVPIGTAAFAMSLCLNFIVSALIVGRIWHMTSLNREIKTDSAIWRASAIVIESGLLFLAAQLVFVVLFAIKHPAQAIVEPIATQIYGISPTLIIVRVGMGSTFEPTSLPESSLRFRVSFGKKSSKMTESRMTGTTTDVEMASSLPSDRTFTSSKVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6P3</accession>
    <name>A0AA38L6P3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiolase, N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_307941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6P3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="288"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="416" mass="43922" checksum="40CA02B68D3624CE" modified="2024-01-24" version="1">MLSRNFLSLSRSVRAMSTQVPRGLAALLEKKPDDVVITFAKRTATGRAKKGQLKDVPVDEMLYHLFKATISGAKIDPAKVDDICVGTCHPPSPLYLSRAAALAAGFPHTVPISTVNRLCSSGLMSIRNIAQGIKSGEITLGIAAGTDSMSLNPRPTPETSAIVDENAEAHDCVQPMGWTSEMVAEVYKVPREKQDYYALISHTRASEASAKGIFAEEIVPITVRGTTISVDDTIRPGVTAEGLAGLKSAFPQWSPGTTTAGNASGVGDGAAVCVLTSRANAEKEGMEIIGKYVASTVVSVEPKVMGISPVVAIPKVLEMTGLTKEDIDVYEINEAFASQFAYCVEELGIPIEKINPNGGAIAISHPLGMTGTRQVVTGLAELKRKNKRLLVTSMCVGSGMGAAGVFVNEARHEANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L713</accession>
    <name>A0AA38L713_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_409739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L713"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="726" mass="80376" checksum="81A87B83C5C83033" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAX4</accession>
    <name>A0AA38NAX4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794596">
        <property type="protein sequence ID" value="KAJ3779581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAX4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="251" mass="28386" checksum="0F32F1DC43D8E885" modified="2024-01-24" version="1">MEPDETTDEETQSSTSLGWWKREIYDYCSYYLDEDGIIQKIYHDPNTEETSQVRAKTPQQKGVLKRHDSPSVIKGVDRGTTPVSFKTRAQPPKYFLQGRRGPISGGTYGPTKLETNRFRSHDSEGETAWHYSQAPHELNTPLPDTPTPRMLGTIYVHRNTEDGGYQIWVWCKRDGRELGWQPVDLENEQVAHPKVTTRSLKLTSGGKPSWVLNSTLLTYRARNSKRSRSRPAEGSTRGDSPVAESASTANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAY9</accession>
    <name>A0AA38NAY9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794388">
        <property type="protein sequence ID" value="KAJ3779686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAY9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="248" mass="27554" checksum="9E515E0A76E8EA6B" modified="2024-01-24" version="1">MAGTQIRIFWATLGPNGRLSRPSDATIVSTVRSALSNRGSWSCPGGIPPIWVIACGPREDHPHYTIRLFYPYSPFAAFTIHQRQSRHEFFASGSPSLTFAAYNPYILIYLLVSPCISIQTSPEHLSPPDFAHIHIEMAGTQIRIFWAMLGPNGWLSRPSDATVVRTVRSALSNRGSWNCPGGIPPIWVIACGPRGNHPHYTIRLFYPHSPLAAFTIHQQQSQHQFFASGSQSLTFAAYNPLFIAQIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBM2</accession>
    <name>A0AA38NBM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_366351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793544">
        <property type="protein sequence ID" value="KAJ3781576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041288552" evidence="2">
        <location>
            <begin position="18"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="319" mass="34898" checksum="23B634F822517673" modified="2024-01-24" version="1">MILLQSVLASLFGYTIATTGSSLASGQIKNLVSFGDSYTDTTAMADGGATWPSYAAGYANVSLFSFAKAGATCSNNLTFRPFPSVFESQLPTYFAEVANGTLSYLPPDETLYTLWIGTNDVGANALLTGQGAPGVSLVDTVSCAIEWVKTMYASGARNFLFQNMAPLQNTVLYSADSYLNHYWTQERNTTEWNVFMSEITHTGNKLQELMLKALVPSLKDVHLGLFDSYSLFEDMIANPTTYLNGTAPLNITGCAHSCVYQLNESTADTGICTIANGTDRDSFLWYDELHPSEQTERNIAKEIAEVIKGERNQWTTWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDB6</accession>
    <name>A0AA38NDB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol-3-phosphate O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_310643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDB6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="777" mass="86434" checksum="C6998F98392B27A4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDY5</accession>
    <name>A0AA38NDY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_346511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDY5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041450916" evidence="11">
        <location>
            <begin position="26"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="509" mass="56773" checksum="C96F61C5571C85F3" modified="2024-01-24" version="1">MILAVAALLVLSLVILYESWRKTFSHQYPLPPGPKKLPIVGNLFDVPKSGRVWLEYAELSRRYKSDIIHLGALGNSIVILNSARIANELLDKRSSIYSSRPFAVMLGELTGWGSVFAFRPNDDLWKAQRKIMNQAMPIGESQRFHPMLIRVTQDLLRDLPHFDILESLHTWAAVLIMDATYGFNTEEAKAYLPTAKVATESVVIAGTPGAFYVDQFPILKYLPEWFPGAGFKRKAREWSDMRSKMTEEPFRLTKERVAMGTARPSLASVALEQMDHDQDLIKQEEVIKTSSVAAYGGGSDTTVTALQSFIWAMLMNPEVQTNAQHELDQVLGVGNLPSFNEEASLPYITAVVRETLRYNPVAPIGVPHKLTEDDIYEGFFLPKGSVIVPNVWSMLYSVEDYPQPHLFNPSRFLDANGNINPKVKNPAASAFGFGRRICPGKSIALASLWIAVASILSCYSIEPELNENGKPNKPQTDSGLTLLNQVPPFKCRFVPRSKEIEVFLGLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHP6</accession>
    <name>A0AA38NHP6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_366632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793555">
        <property type="protein sequence ID" value="KAJ3781472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="33"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3781472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="395" mass="44518" checksum="D3265C1CCAD10E5C" modified="2024-01-24" version="1">MTINLAFLPLPASAEPSHFLTFGREVKDIHPGNCTLEQLEDIKQALYQHEILLFRDVVLTPKQQFSLTKAFDPDSEIYGHGAKLETETSSILHSALHAIPRVPQVQLIGNGMIHNHEGLSNARLNHSTHKTFHKTVVSLEDEAKGFTRFYRWHIDAALYDLSPPKVTTLYAVRVPKGPNQTCRYDDGTGDELDVPLATTAFVSGQTMFQQLPPELKSVAVRTKVKYAPHPYVWMAPARAKPTGLGIESDDLESPFDQLPPWVEDKIKIHPMLWQNPVTRMLSFQVHPSCATELIISPLPINTARERALYPDGAHIDDLKEVRNLLYRMQRPAIAPNLVYPHKWNEKDLILFHNRGVLHTVVGTLRPDQVRVYHQCNLAASGDPTGPTSEDIIQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHX1</accession>
    <name>A0AA38NHX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_409092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793495">
        <property type="protein sequence ID" value="KAJ3782162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="337" mass="36215" checksum="906AE5715E78B10A" modified="2024-01-24" version="1">MATQQSLVLESKQGALIISQRPIPQPQTGELLIKVQAVGLNPVDWKIQARGFLVESYPAVLGSDAAGDVEQVGEGVVGWEKGFYRNERATFQQYTTIPADLVAKIPSKYTYSQAASIPVSLSCAIYGLYAPKPLGLGLNPNIDSSVKQTGQPALVLGGNTSVGLYAIQLLRYMEFNPIIAYASLKHFVYLKSLGATFIVDRQEVSLADLPSAVARASDKPLKVAFDAVGNAEAQEAGMSCLVEGGELITVNSTTKSDSDDGKIMLAVFGTVHLPHTRAFGKVLYERLPQLIEQDVVVPARVEDLPNGLQGIVDGLQRLKRNEVSGVKLVGHPQEQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHZ9</accession>
    <name>A0AA38NHZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_408325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHZ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="124"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3782432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="484" mass="53867" checksum="A9ACF7F52194D787" modified="2024-01-24" version="1">MTSTRYAPKSYEDLRVLLKDDNKVKVAGIDVDGVLRGKFMSKDKFLSAASSDGFGFCSVIFGWDIHDTVYSRELLISNKANGYRDILASIDLSTYRRIPWENNVPFFLVSFLDPDTKEPLVVDPRGILKITSDRADKMQRSCYAGVEYEYFNFKETPVSLAEKKFQNLTPLTPGMHGYSLLRTQLNNDYFHSIFDEASRFGVDIEGHHTETGPGVLETALAYTNALRMADNAILFKYLTKSVGMQYGVVPTFMAKPWGNLPGCSGHTHVSLRDKSGRNIFAVSDAELSNGRPGAANDDVKFLSEEAEHFLAGILDGIADVMPMVVPTINGYKRLVGGEAFWAPNAITYGYDSRAASIRIMSPPSVPPAATRLEIRVPGADMNPYFAISAIFLLGLRGIEKKLELSTLPMSKLSADDKKNGTIKMLPTSLEAATERMMRPESIAREKGMFGDVFVEHFGGTREHEVKVWNEAVTNWEVERYIELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIE5</accession>
    <name>A0AA38NIE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794591">
        <property type="protein sequence ID" value="KAJ3779583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="84" mass="8784" checksum="EF358F60B230BA67" modified="2024-01-24" version="1">MRPFAQQLAAQGNELPVAGAVATQSVASPSTEGHAIEMAPRIIDWDDTQFNATGDPVIDYGEDNGMDMAGYTQPQDGGGCNSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIX3</accession>
    <name>A0AA38NIX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_391228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793721">
        <property type="protein sequence ID" value="KAJ3780498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="279"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3780498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="322" mass="36486" checksum="259E5DD32C5B094F" modified="2024-01-24" version="1" fragment="single">MFKLSANGAKIAYNACRKWFTIVSMMIGPVLFVINAPFGRFALNGKSIFLLDGRKSWIVMELVSPLMFIDTFLNSPLSRGEPVSFEPSLAQYVLAGAYLTHYLNRAIVSPLRTPSRSKSHIIVPLAGVLFNTLNGFLMGTYLSSPAAFAYLSCSRPTFFVGLSIWAIGFAGNLIHDEILLNIRRKASSKPDGKATRSSGKTTENEDENIPEHYAIPYGMLYKYISYPNYFCEWIEWFGYALAASPFPFDTSSLGYAVRALRSPSIIFESSSVFAPRLTPPWIFLLNEIVLMLPRAYKGHRWYQERFRDSYPKERKVIVPFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ30</accession>
    <name>A0AA38NJ30_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793658">
        <property type="protein sequence ID" value="KAJ3780768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ30"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041294687" evidence="1">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="165" mass="18077" checksum="2EE08FC7A592DD80" modified="2024-01-24" version="1">MRLSTYLALGFVLVSAAFTAPLTTRDTAMVGIRAGPASGIEFTIEFEAHPYVGIHEHLTAEYNAAVERNVRALIRKVAASDLDAPIGLDISFNWKNTPSPDASKPVKYKVSTEQHGQYIVVMSHETPMTNVIVKDSMGRVIRQEGNRCSKGAIYNIIIFGMVDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ63</accession>
    <name>A0AA38NJ63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_380874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="MU793808">
        <property type="protein sequence ID" value="KAJ3780289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ63"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="6">
        <location>
            <begin position="41"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="262" mass="29676" checksum="FFA9870FE73C2852" modified="2024-01-24" version="1">MNGDSPNTGSPSPLSLSNKLNSIRTLIRPRLPHDIHDYCKALEGFHVISVVRTGGGKTTYFTGYIILLQELEKVSEDHCLKKTLNRTIPEDPLCIIVYPTKGLEEDMADQFNSLGIPSLAINEDTIRAARNKRTDLWAQAMDPQLRCLLLSPEQLSSKPFNTALSNRLFYSRIIALNVDEIHLILTWGVLGFRLCFRDIGNMLMRLPRWTTLTGVTATLSAGTDTQEVTRMLGLKSGSFTFMRRSNRRPELQLILFCYERFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ85</accession>
    <name>A0AA38NJ85_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_269819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793350">
        <property type="protein sequence ID" value="KAJ3785192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ85"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="1">
        <location>
            <begin position="11"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24918" checksum="1227E7C3A7A29752" modified="2024-01-24" version="1">MLCIGPYSAWVVVDGVGLETHCAEASHSICTASTSGWISSEAGKKFSVYWHNAERDIALEAVVSIDGVECNRHVMLSARDFPDRPDTVRVSYTRTSESTRRDFIFSVIQLTDDDEWLPLVDYTKFGVITLELWRLRVNRVVRQQLQHDCYKPLILEPQVLHEQTKRSGIHHVRFGEEYNVSRPTVDMVDGQKMDRVPYASFLFRYRPRGLLKSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJI2</accession>
    <name>A0AA38NJI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="2 17">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_414419</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="2 17"/>
    <dbReference type="EMBL" id="MU793644">
        <property type="protein sequence ID" value="KAJ3780844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJI2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 17" id="KW-0288">FMN</keyword>
    <keyword evidence="16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="16 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="20">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="20">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3780844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="682" mass="75416" checksum="AB5456C518AF29D1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJM0</accession>
    <name>A0AA38NJM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_427716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793329">
        <property type="protein sequence ID" value="KAJ3785867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJM0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041323863" evidence="1">
        <location>
            <begin position="22"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="451" mass="49364" checksum="00C3CE1A5DCE5B3A" modified="2024-01-24" version="1">MMLFAVVLGLQYFLLTSRVNATAVFAHFMASTLSYCVQNSYSYGPSDWAADIAAAQAIGIDGFALNTAVDTYEISKYPDAFAAAEAANFQMFISFDMTYDWAEADMVSLVQTYATSPSYYKWNGNSLVSTFDGDAQDDDFWAGFKSDLANEGVTISLAPAFIDYRDPSEATTMFSTYTSIDGFFNWWSWPADVAADLTTATDLAYQAGISAAGRSGPYIMAVSPWQFKELGGTNDWVEQSDELWKYRWEQAISDVKPDIVEIVTWNDYGSSITTQVSLISMDHSLGESHYISDINPIVNLGDLAPLYVDGFDHGAWRTMAQYYISWYKTGSVPAITEDQVVYWYRAYPKAITCSEGDLPRNSEYPADAVFAFSMLTSPATITLTVGDSSASFDASAGVAIGSVPFSTQDAQMPVISIVRDGTTVKSGTGTKAISMSSCPYYNFNPLVGIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJS5</accession>
    <name>A0AA38NJS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_178254</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJS5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="14">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="13">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="415"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="260"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="678"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3786137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="760" mass="82465" checksum="43EC447C86FF8F06" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK81</accession>
    <name>A0AA38NK81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arsenical pump-driving ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_86726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793497">
        <property type="protein sequence ID" value="KAJ3782134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK81"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="36940" checksum="76162187DC381E3B" modified="2024-01-24" version="1">MEVSTPEFETLEPTLQNVLDQTSLKWIFCGGKGGVGKTTSSCSLAIQLARVRESVLLISTDPAHNLSDAFGQKFSKDATLVNGFKNLYAMEIDPTSAIQEMVEQSDSNGMMGSMMQDLAFAIPGVDEAMSFAEIMKHVKSLTYSVIVFDTAPTGHTLRFLSFPTVLEKALGKLSTLGSRFGPMINQMSSMMGGEAASQEDMFAKLESMREVITEVNSQFKDPEKTTFICICISEFLSLYETERLIQELTSYEIDTHNIVVNQLLFPKKDSNCTHCGVRRKMQQKYLAEAHELYAEFFHIVQLPLLTEEVRGPEKLKEFSKMLVEGYVPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKJ3</accession>
    <name>A0AA38NKJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKJ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041390268" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="145" mass="15027" checksum="02525EA859F3A4A6" modified="2024-01-24" version="1">MRFFSAMFSLAIATTSVVSQSANLGAPADMTQVAAGSDFTVMVDRPDTLTGSIEVAVVIALLSCASNPCPGPSAELGTVLYNGPFNPQFTTEPGTTNLPPHENFTLTVPSSFTKGNAQLGVAHVYLLGASVSPELETFNTTIVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKL6</accession>
    <name>A0AA38NKL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_73291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793455">
        <property type="protein sequence ID" value="KAJ3782764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="259" mass="28023" checksum="9D32BC056A3701E7" modified="2024-01-24" version="1">MTEYDYSPAAYQRYMETQNRIAKWVDNTEAHHEAFCVPFGPRSDMGEDDLAGISDAEEAIPSGASAGGWYEEKRRNGARKNVVAPPPPIFYHSQPAAPAPMYPGALASAPVNYNYPTPGGYTSPPATPQIIIQTVPKHRSHRHHDSKRSSSAESRKAKSKTRMYVLPSSASAAPPMQMQPPSYGYPGAQPPPGSYNYPLHSAGPYSANPAYAPPPPSFSPPVSGHPMMSPSPSPSPYYSQPGGYVIIPPKGQHVRVMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL77</accession>
    <name>A0AA38NL77_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CTAG/Pcc1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_377378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793405">
        <property type="protein sequence ID" value="KAJ3783769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL77"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="92" mass="10282" checksum="F96D1343C6C0B933" modified="2024-01-24" version="1">MTENWHSVTLNIPFASEKHALIAKQVIEVDSELQFHVVKRTIEVDGHVLIAAFSTLTVRLARLAANAFLENVDLVVRTLERFGEEAENPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLX8</accession>
    <name>A0AA38NLX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_354736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLX8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11850" checksum="57DCE774DB8DFEB7" modified="2024-01-24" version="1">MGFFHHESDEAQAYNEVVNAPHKAELSHELIAAAASYEAAKAYENHCAANGKPDNHAKAKELLAAFSGAFVDRIVETKGLDYVDAEKAKHHAKKQAEEGLQSNPEWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNI0</accession>
    <name>A0AA38NNI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_111160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNI0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="11">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="9">
        <location>
            <begin position="192"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="10">
        <location>
            <begin position="684"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="854" mass="97505" checksum="63F842F95ECC7468" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNN0</accession>
    <name>A0AA38NNN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_300184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793608">
        <property type="protein sequence ID" value="KAJ3781070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="294" mass="32882" checksum="1EC186B40E1367E0" modified="2024-01-24" version="1">MPPSRLSTVFDLSGLRLHTDGSLVLQSTRNTDLRLSKLTVQDAHGNWSAKDAGGLASVPKYRKVLPVPREDEGKRSIEEDDLDIAVPLGGTGPDILQQPHLKTSRARKRRKFATDEEYLAPMLPLYNSPALEDDLEPQPQLTPPSSDLLKCIHHYASMYYNERGLLLNASQQYRKQKKERRLARLALVGKTTRTMTRSLSDTENPSGSEEDEIIDDEHGDEESEIDHQEKPTKAPVRRDDHDLADMYKTLDGSALMAIGMLLQEHVAELLYPQTSFDSEDSQMSGEITGTNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP68</accession>
    <name>A0AA38NP68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_56466</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1649"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1674"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1699"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="18"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="1010"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="21">
        <location>
            <begin position="1961"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1773"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1792"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1812"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3783320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2018" mass="223976" checksum="361DBDBC4FCD6EAC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPI8</accession>
    <name>A0AA38NPI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_269965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPI8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF5">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="193"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="446"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="644"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="881"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="944"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="959" mass="104394" checksum="341CAB2883BD7EC3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPW0</accession>
    <name>A0AA38NPW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_265979</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="367" mass="40702" checksum="2568E83D3ED41628" modified="2024-01-24" version="1">MSTATTRSDLSLPPPESDIPIFTTVASYREWRRKAFIENRSVGFVPTMGALHEGHLGLVRRSLSENDLTVLSIFVNPAQFAPHEDLETYPRTLERDLKVLAEQQVVASNSDMSSNSIPTLDSNQVKRPSAVFLPSVREMYPGGIEQEIVKQRGTFVEVTAYGEQMEGKSRPGFFRGVATVVTKLFNVIQPTNAYFGQKDIQQALLLRHMVTDLLLSHPSPDHLHIIPTARDPSDNLALSSRNAYLSPAGRKVAPTLYAALKAAEECWLAGEGDEGGKNKNKKECVEIARALVERRIEEVRDHGLDVEITLDYIEMNDAGTFEVLDDSDTRSLRGNEAAPVILSGAMWVDRTRLIDNLLLGDFGTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQE3</accession>
    <name>A0AA38NQE3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_384279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQE3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="754" mass="84190" checksum="3D0A9D83DE0D5D1A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQT2</accession>
    <name>A0AA38NQT2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_304942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="644" mass="70019" checksum="598C4C27ED7BF075" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR95</accession>
    <name>A0AA38NR95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Succinate/fumarate mitochondrial transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_342970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR95"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="319" mass="34198" checksum="0AF2502919A832F2" modified="2024-01-24" version="1">MSRNNGSKKPVGFATHVTAGGIAGACEALTCQPLDTIKVRMQLSRSGRLPGTKPRGFFATGAYIVRRETPLALYKGLGAVLSGIVPKMSIRFASFEAYKSSLADPETGKTSMGNIFIAGLGAGTTEAVAVVTPMEVVKIRLQAQQHSLADPLETPRYRNAGHAVYTIIREEGFSTLYRGVSLTALRQATNQGANFTVYQEAKKFAQRIQPGMEELPSYQTMMIGLLSGAAGPLSNAPIDTIKTRLQKATAAPGTSALSRITVIAKDMWMQEGVKSFYKGLTPRILRVAPGQSVVFAVYERVSGIIERMQPSTGGDAYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRZ2</accession>
    <name>A0AA38NRZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_10371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="40590" checksum="F7F55E7A9BC62AAE" modified="2024-01-24" version="1">MSVRVLTGSDVRNITTKLSSDFLQSLMGDVFALISSSEDATSYLPHRTSIPTENHTALFMPARISSIGTTMKVVSVPSRSDDTRGLPASTLVLDKHTGTVKAIVNARSLTALRNAAGSLLSTNLVGLTSPARIVAFGAGEQVLAHLDLHFRAFPSVKSCTIVNRSLNDRLSSVTAQLAIKHPSVNLSVLAYDALNVTDEEKENLQTCLSDADIIITATPSSIPLFPSSWVRSGAHVILIGSYTPHMKEVDTDLIMRAIPTSFHNEAQLPILLVDSISACFAEAGELLEAGIHPSQVIEIGKLVLDERNHVQSRTETRDSYYKSKDVGNDFVGPITIFKSVGVGLQDVAIACAVVDMAEEMERSNFKGSTGVVIPDFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSK7</accession>
    <name>A0AA38NSK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_258610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSK7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3790353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="482" mass="55095" checksum="74E104CB768C73BC" modified="2024-01-24" version="1">MLITVFFSIVILLVLQVFKTLHLRSKLPPGPLGLPILGNLFQLPTSRPWLAFDRWTKKYGPIVYLNIAGQSTIVLGTHKAAADLLERRANIYSDWPDFIVLNLLTDGMHWGFARLDDLWRRQRQASYEALSAHTTKEYYPYQETESVIMIAQMLTNPEQFTDHFLRASTSLALSLVYGWPPLLDSSHPTISQIDQFNREMLETAAPGSFWVEFEYFKWMQYLPRWMCMWKRNAEASFIQNSAMFESLTADVQRKIDAGDDTPSVAGKILQDTENKMSFEAAWNSASIYSAGAETTAGQLAWFMQAMILYPEAQRLAQEEIDHVVGPHRLPTFNDYEHLPYIRATVKEILCWRGVSPIGLPHRLSQDDYYEGFFIPQDTICFMNNWSLHHDKEVYGDDAEHFNPGQFLDVNGKIESSIPGTKDEGHFSYGFGKRICVGRHVANNSLFIHIASLLWAFNIVPEVDSDGKPTFPDSLQCQEGLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSQ0</accession>
    <name>A0AA38NSQ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_340686</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSQ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18435">
        <property type="entry name" value="BRCT_BRC1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 15 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="370"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="664"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="907"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="801"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="801"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="844"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3790400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1017" mass="115943" checksum="E7DB447308A1E747" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTD5</accession>
    <name>A0AA38NTD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_281674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTD5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="306" mass="34704" checksum="8D8B53A4A07E8E1E" modified="2024-01-24" version="1">MSYTKPTAMGKAADAILGCFAVFSPPEFIDHLVRYLGTWSGSDKLFAIIEYTLKLLVPLLHKRAQIQKNAGLRKIGVSSTAARFSKFAGSISSSRTLWRFWGLLTIIRWMISLENTAQPTRKLLNIERLQGWSMFGYYPLEHLSYLVSNEILPSRSTIDLSPFITKKTKLELNAGKMSLWSVRCWAVYVALQFAHLHEDRKLLQARYHTLRKAGLKPAEKQELQKRWHAYWSDLVVNMANFPLALHWSMGSRLIKQDYVVALLNLIVAIVSFRSGWKATALPSTPPASSIDDSPEPVFENVTAYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTK9</accession>
    <name>A0AA38NTK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_236888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTK9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="266" mass="29807" checksum="A8B072D2AD2F4E6B" modified="2024-01-24" version="1" fragment="single">DQKQCRICLDGVDAEQELGRLIRPCLCRGTISYIHVKCLQRWRNSSQNQSAFFRCGMCGYSYRFSRTRAVGIASNPVIVGCISAFIFTLLTLVSSYITTHLLTYFQGPSSSSFYISSSSYWFYDPTEVIHDLVRAALGILQDEDFDPETLLARGQTTGASFAASLNTKEGSSFLKRFIQRFVIGLPLIGASSLIHMMISLPFIGPVHWLARFRGRRRNNDRDISAIIIVVLIVVGAARALYAVYQLTQSVTKRLLLRAEDAILEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZ26</accession>
    <name>A0AA38TZ26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_342430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZ26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="126"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="561" mass="61072" checksum="0335971A96551DE7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZL5</accession>
    <name>A0AA38TZL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="12">ITPase</shortName>
            <shortName evidence="12">Inosine triphosphatase</shortName>
            <ecNumber evidence="12">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="12">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_341238</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="12"/>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZL5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3790165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="186" mass="20528" checksum="F9E2C43F75224C63" modified="2024-01-24" version="1">MSKLVFVTGNANKLKEVQAILSAGNQPVEINSKSLDIDEIQGSTQEVAKAKCRRAAELLDGPCITEDTALCFEALDGLPGPYIKYFLEKLGHDGINKMLVGFESKKAWALCTFAYCAGPGSEPILFEGRTDGTIVPARGIAKFGWDPIFEPIDTDLTYAEMPPEQKNRISHRYKALEKLRVYIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0P1</accession>
    <name>A0AA38U0P1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_339431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0P1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="72" mass="7940" checksum="9F2CED79EE03673B" modified="2024-01-24" version="1">MGEMTYLSDHIVLLCFWLSLAAFGGFGRVNISICKSRKCLKKERQSEKAGWSANFCKRARGGGGSCSFRGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1P0</accession>
    <name>A0AA38U1P0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SEN1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_382696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="1276"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="954"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1767"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1391"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="911"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3791292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1890" mass="213055" checksum="8C4D68A47E53910C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8C4</accession>
    <name>A0AA38K8C4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_379287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793532">
        <property type="protein sequence ID" value="KAJ3781704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8C4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="31999" checksum="D7D799B183029323" modified="2024-01-24" version="1">MNLSLTAIPDRFMPAVSNGSCPKPITPVAENRSERARRRSAAYTSTKRSPTSSTPTPTAFDPIPESPSEPDSAFEILSNASPLTLDQASLPLSRNPSPSSSESSVSIDMSRNVSGSGWVDMGTSKTGCQLLTPNPSLDALEELWGYVATNLEDREITDETLKKKEFLRCFAKWASLKDILAEISDTLTNKDWITLNGTGSNPDDFACRPFFDTIRDKILGNDWARLYDMKREKYVMLADPTGFSKLVTLMETHNRRLRGTMYHCSNEVLQTLIMSGSVAYTTNTHVQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8T1</accession>
    <name>A0AA38K8T1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amine oxidase</fullName>
            <ecNumber evidence="14">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_74252</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13 14">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="14"/>
    <dbReference type="EMBL" id="MU793459">
        <property type="protein sequence ID" value="KAJ3782694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8T1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="17">
        <location>
            <begin position="138"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="310"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="12">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="13">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3782694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="759" mass="84774" checksum="5B1E649AB9C43FB5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAE5</accession>
    <name>A0AA38KAE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_352944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="470" mass="53462" checksum="51CDCFCC7B6D2A9A" modified="2024-01-24" version="1">MQSSRMAGPEYAYPNAAKSVSQYIQQYDKNSLLPLQEIDIRSSVSTRARKTFYFLRADVNDTTPKLNGLKFQLPIDTGSIHSWLFIENFKFIKNSDEVQWPFTVKRPFMFDNIPGRVVQYGSNGYVYMHDGPVDSKISVTLHGWDWERQDDSKTGFKIYDGFDFVSASNMRIISDGYDGNIGLGPRQGDLQTEASRSFLASLTATRHVRDASVFIIRLVHPDILDHIPLSCVLLNIISFGPEFPLQAPVNPDAEFSSPIPVVSVAANNSIRPRKWEVRLLRIGISSSDNSDYSWIDMDDPEESLKSSIKGINILMDTGTPMTVFPSYVLSKMQSDERWLGPSMHKDDKIFLSDSRFERLLREKIRFEFQGEGRHTVGLVLQAKAFMSWYSKAAAGDDPTSHLCAIKGSKANFALGQNWYWAAIVKHVSPRERRKYPFVQVMPNGYFFDRETRKPVKPTDMILKTLPPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC80</accession>
    <name>A0AA38KC80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_115708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793575">
        <property type="protein sequence ID" value="KAJ3781303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="136"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="308" mass="34267" checksum="A657179F9999F476" modified="2024-01-24" version="1">MHDHNALADNLPKTNASDQFGSSSVVRVRVFRKSDSEVVRRLFKTCLLTGEGAPPRAHLAATIQSPSFLCALTILIMSVITAAMVFNSEPASHILSGRSSAKIRLVMVISTALLALWYLCYSIYSAVGFYLRFVSTCLRTDLMDIQGHYNLHEVKKSSSDKILEDSTDPELRPMGIKAFWVAETMSPVTQKTEIVGCISLGDPPPPPFTSEPGVRVAELCRMVISPHHRRQGIAGALMQACEAHAMANEHKLSAIVLRTTFYQPHARELYAKLGYRIALETNVRFGNADIPVFLYRKDLMNHENKQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC99</accession>
    <name>A0AA38KC99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_284924</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC99"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="44"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="40568" checksum="9EEFAB4501C6E4F5" modified="2024-01-24" version="1">MLRNALSAAARLPALSQARTATTLSAGFPKVTKRPSTKYGGVYTVTLIPGDGIGQEITDSVKEIFEHVNAPIEWEQYDVSGMSSSGEVLFKQAMESLKRNRVGLKGILFTPISQSGHISWNVAMRQQLDIYASVVMCKSLPGFPTRHSNVDFTIIRENTEGEYSGLEHQSYPGVVESLKVSTRAKAERIHRFAFDFALKNNRKKVTCVHKANIMKLGDGLFLNTFREVAKEYESSGLTFNDMIVDNTSMQLVAKPGQFDVMVMPNLYGAIVSNIGAALVGGPGIVPGCNVGREYALFEPGCRHVASDIMGTNRANPAAMILSATMMLRHLGLDNLANSIATATFDVINSGKVRTADMGGSSTTSDFTTAVIKSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDS7</accession>
    <name>A0AA38KDS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_336366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793559">
        <property type="protein sequence ID" value="KAJ3781436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDS7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="308" mass="34392" checksum="17F5B0A15B18B5E3" modified="2024-01-24" version="1">MASPNLLLPLFQAISSNQAAICSNVAALTILLYDCLLTFDNEVKYIWKSQWTIPKVLYLFAKYYGLAHLCCVLMVSNITNLSFKLKLLDMQTLPVVVHPVYAFMHCTGLVNWYTGILTESSLLAHSGEFTTNLAQAEFWGIYKSMIIETSTPMIDLDAVEFIIPDIKHSLSGCAFWETSSLNFNFTLESYVPNLFVSGVFFCLMAYGCSVRSPPWKMTQWFKNQDSSSNSSNTVSTSTGNTIHFVIKDGTIFFFLQGILWIIGVYSFAGTKLILNLREVTDTGAGRFPSTATVGTLHTFQVHIPEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE22</accession>
    <name>A0AA38KE22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_271206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793371">
        <property type="protein sequence ID" value="KAJ3784588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE22"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="395" mass="44758" checksum="BACFF995C0DE3A4A" modified="2024-01-24" version="1">MSLQQSVFSFYRQYLRQVKRLPHTHLRQFFRIKASDDFRALVATPAHKSQLRDSKMKRISKDLRRIKLALTGRQNAFSYILDLAYGRRGKLRWELMEPLLAQANAPSLPDPMIRSVPSSRPPVYSPELSALLINTASRTNKPLELHQLKFPPTLSARADPTSEEARLLGLLSRRLELNTRWRYFAREWKKVYPPLDIAVKGNDGLLSTSVNDVENAGGRMLGSQDQGLLPGVEDIVGPPTAGTPITRRERLLGIQQSTSNSSKQRHPSRWLRRRYQALLGRLPVLILNKGHKKPSYGVHLPLSSIALVGRNAAHRRPALDAPNLAWLEHANVLEKGKPKNRVRFSNRAKTHGANSFAGTKVIVTARSTSISQNSYSWKQNVRNNSYSLIRINIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE26</accession>
    <name>A0AA38KE26_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_23361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="369" mass="40392" checksum="F955CCA4656C91CE" modified="2024-01-24" version="1">MAPPRPPFGTDEPESIYETPNHPQRRIRQPAPVDPNSRTSAYNVYNTYLHDDTNRQSGIDALGAGFMNGSMDDDDDELEEKYNPFTSAKEKEASKQAMLAAAIGPRKTPTPPPQYIASPRPGYAAPIEALSRPEPAAVPAIRQSPNGLSINTSNNPFATPMDRQAFPGGPHIPQPIAVPSTPHPLQPPMTPITPVFARPRQQDVHFDEKPIMRGAGEGTSIPSRGEKGDDFWRRFSVVVKEQNSKPAQLKQSSWLKTTQGRTNSMFRWVFFIGMILAVCALGAIGLWWYASHNSTAHDQPQALGGSEKESGSSSTVGVASSAATLQASLHVSPTNTVARRILDEVYEPQPTGLSSHKWHKRVLHLNRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE67</accession>
    <name>A0AA38KE67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_293387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793361">
        <property type="protein sequence ID" value="KAJ3784858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE67"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="272"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="479" mass="53737" checksum="573A0F8EF0E827DD" modified="2024-01-24" version="1">MFRRILLTTNCEYGQANVVLALAYELATRPGVKVAIASFAPLEKRVMQLQQQLRDAKHDSDILFHPLPGRGHIEAVGMTRLDTPHGPGVKQALHSFRYAPSMLLPWTESEYMEQLTTIENIVHKFEPEVVVVEWFHRAGQDVCKKLGLKFFVITPNSSKDIIGFRQPWATGLWKFPALSSGYAYPLPWSKLIPNMFINLMLISGIKLSMTVHKADKMRKIYNKANPPILVDPEIQYLCPSAPDLDFPVTVPDNIRLCGPLVMPTPPIHKTDPKLAAWLDQAPTVLVNLGSHVTYDCSAIGQIAGGFRPLLRRHPNVQILWKLSPEGDVQEALDEYIENDVDIRGRVQVVHWLQSEPLAVLQHPNLICSVHHGGANSFFEATQISSRAGVPHVVLPVWYDTYDYATRVEWLGIGLWGSHRSAPNAEASELAEALLRVAGPGEEAESFKRKAENLAENCRTRYTGRVRAADEILTLYTDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEV7</accession>
    <name>A0AA38KEV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_291532</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEV7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="64"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="577" mass="62722" checksum="00D62CD69D408836" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFB6</accession>
    <name>A0AA38KFB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_316026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793401">
        <property type="protein sequence ID" value="KAJ3783851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFB6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="207" mass="23548" checksum="2C5D82CE47DE4FD8" modified="2024-01-24" version="1">MTSILSLYSAAFARRPMATQSTTSAIIFGTGDIIAQQVVDRKGFNNHDFTRTARFVFYGACLFGPVLTKWHQFINRRHFTSPLRAVVYKVTLDQLVAAPFITVPMFFGSMSILEGRPDEAIPRIRNSYVSTLTRGWCLFIPAQIVNFAFVPVPMRILFFSTVALCWSTSMQFIRVKSEIFKHNSASSTDTYLSFFNAKQKRLQERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG33</accession>
    <name>A0AA38KG33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_355730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG33"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="276" mass="30384" checksum="F8BE5D070EDE6641" modified="2024-01-24" version="1">MFRSAICRLPPRGKIFSLGSVTSSLPWPIYHRFTNKRTFSVIQQTRNTSASPTQNSNDSRNGFVDSTDPNLIYNAPLTSTFRRLKIFSLASLSLSCSLAPLIFVIESQLPFFARSCLAGLAVGTSGVSTGLIAWVGRPYVTTLRRLEPENGGAMGLEFTTANWRLQTRITRVYDTSFLTTTDRPFAKWQLANELELPSLSSSSKATPAATQNLEETVAETFDADGNVLGSWVVTWVSPQSKSEEGVKAGNVLGKCRSVGHIVKHFQVHEELFEVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGE2</accession>
    <name>A0AA38KGE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_332878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGE2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="286" mass="32441" checksum="F80DC24F1B2A81D6" modified="2024-01-24" version="1">MSELSASDIQIQVNWDHYVELIEFVLSVILIYDYLLTFDIEIERFWKRETKRFASILFFINRYMTLLGNIPIVLLFFWPEPGRGALDLFAQILIFLVQFNISVLFVLRMYAIYSSSRRIVAFLSVVLTAMVVNNVVQLYLADRTGLAAVDPPSAVAQIGSIPSFSNAQGLHLAYLWIGIFAFDFCVFSLTLWKTYYMYKDGYISGGIGTVVMRDGLMYFGIITLANLGNILVFAFGPEFTKGLLPVFSSIISSVIMSRLMLNLREENLNETQLSGLLFANNSENDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGJ2</accession>
    <name>A0AA38KGJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_373042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="541" mass="61265" checksum="D2FE27C6396E76FE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI33</accession>
    <name>A0AA38KI33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_409378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI33"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="91"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="36916" checksum="01F01CD5072F5A54" modified="2024-01-24" version="1">MRQIQTSQTQLRRQIRERRQYVYAKSLEAQERQTYERKQQLKDALATGKPLPTELKKDAKALGQELAFDEAQVDPTSHIDNEYTRAGIQDPKIVITTSRDPSSKLLQFAKETRLVFPNSHRINRGNYVIKELAEACRANDVTDLIILHEHRGNPDAMIVSHFPHGPTVFFTLNNVALRHDIATYKESTVSEQYPHLIFENFTSKLGERIRDVLRYLFPVPKEDSKRVMTFANEDDFISFRHHVFVKIPRQVQLAEVGPRFEMKPYEIRQGTIEQTEAEREWVLAHYSRTAKKRSMLSGSGSYSAPRNSRQPPAKKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKJ4</accession>
    <name>A0AA38KKJ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_401828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794628">
        <property type="protein sequence ID" value="KAJ3779565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKJ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="116" mass="13011" checksum="5FA516CA3D550E15" modified="2024-01-24" version="1">MNSPNSEDSWIPLSDIPDSFNELIDKFHHRHPRSPRPPQFILDFARRAPLDSTSHNSDSTSPSVLSHRPAIPPAIRRPRSPSAVHHDPRTNYVPPAQTTTRSGCISKPPQRLDPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKW4</accession>
    <name>A0AA38KKW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_128848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793638">
        <property type="protein sequence ID" value="KAJ3780869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="178"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="354" mass="38270" checksum="A16605981AEF2DCC" modified="2024-01-24" version="1">MSATSGIGVSQELSSQFSSAVDSKSVRFLKISIQNESIVYDQSIPIEGSLTEDLPKLQDLLQDDVPAYILVKLDDPATDWLAIYYVPDSAKVRDKMLYASTRASLLKNLGSTVFTDSLFATSKADLTPEAYLAHLKHIAAPKPLSAREQEMEDIRLAELSYAPAYEGSRARTSIVGTGVGLNWTTNVENAVTELGQEEGSGIVILTIDPAAETLLLSSKSPVTIDTLKSSLPSSEPCYAFFAWPHSHSDPPRREIVFIYSCPAVSPVKHRMLYSSGCTGLFQAAKTLLAQSSSHFSARKVETSDPTELDEAYLRSELSFDTIAASGGNGATIKSPLGDTAKSFAKPRGPARRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM04</accession>
    <name>A0AA38KM04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UbiA prenyltransferase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_366233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793541">
        <property type="protein sequence ID" value="KAJ3781605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="315" mass="35006" checksum="E5BD16698E7F5E11" modified="2024-01-24" version="1">MSKRLANLLAPPSKEEFNACWDLCRLNNHMGCWTTWIPTAWALAMVYHAHPEIPGSVALLWAAKYLVLCSGIKSLIMTIDDILDHDIDAMVSRTKSRAIPRGSISLDRAWLFFGMQVVLGVYLAQALLDPISCRFAAAAAPLFVIYPTCKRWMYFAPVTLGLMFTVGVFMGWSTLSPTREIPYEILVPVYIAGCFWVWTYETIYQHMDKADDVKIGIRSSALLCGQYTIPVCSTTAIVFFGLLAYGGFLNGHSYLFFAGVLLAAFLLISKLLRTNIDRPADCRDFFLQTPLIGQILVGGFVADAVVARISNGIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMP9</accession>
    <name>A0AA38KMP9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_363497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793469">
        <property type="protein sequence ID" value="KAJ3782535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMP9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041382890" evidence="1">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="177" mass="20133" checksum="70F30525A33D8DBB" modified="2024-01-24" version="1">MHLNPAYLFFALLPPVAYAAPTTAGSSNLSSRGQLLVLPAKVHVKIFGDPHFTYLPFNELHRERLQPRLKSIFEYWIRNTKMIKLDKEGKKITIDIPLEPLDIVIEDGSITVLDKLEFWGPGVKEIPGLQGCESQEDRCFANVFPEVVYFRRGGVDLYYVHRNATGYGEGLEKHNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMX5</accession>
    <name>A0AA38KMX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal enoyl-CoA-hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_429312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793451">
        <property type="protein sequence ID" value="KAJ3782820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="33980" checksum="CB20E8F0A1CA7E90" modified="2024-01-24" version="1">MNYVSTTAVTPAVSPFDALNLTDVTAKLEDSILIVTLNRSRKMNSFSEKMAADLVRIFQFGDQDDRVRAIVLTADPTAPAFCAGADMEEVARGSSLLGRKEDTETEHRDPGGQVAMAIYNNRKITVAAVNGHASGVGLTALQFPFDFRIIWSGSKLTIPFVRLGIVPESTSTYLLSRLIGESRATAVLFSGAVMQPDSPVISNLYFQILPDRTDVLPAAVILAKNISVNSSQTSIAYSKGLLHHAGSSIEENHLLDSRAMKLLGSSRDAAEGAKAFMQRRKPNFPDALSRSLSPWYPWWKVTDVRHPKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN86</accession>
    <name>A0AA38KN86_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic integral membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_361734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN86"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="357" mass="39684" checksum="85FF6789D4710262" modified="2024-01-24" version="1">MAVLQSPITFIASIPTVTRYFTLATVTVSLVYAWLQWNSEGAKLFPYLVLVPGSSLFYPWTFVTSALVETTIWELAITIITIPPTLRYLERLWGSLETFKFIVATIFVSNIIAFGFNWIEFIATSDADLFLYGMSYHGQMSLQIGVLVAFTQLIPEHQVQFLGFLKMRVKSLPMTYLTVSTVMTILGFQCPWIIIQFGWFVSWIYLRFYKKNSSDTVGGVESYGDRSETFSLVSWFPPFTHVVLGPGGNFVHKWANKLHLIPSHGGDIENGFNTIPGSARAEAERRRAMALQALDQRLAHTSSPSPQSAAPVSAHTPRPPPAVASPRPEKVVPPADYVAKASFDSESGDLGATEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP09</accession>
    <name>A0AA38KP09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_272535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793399">
        <property type="protein sequence ID" value="KAJ3783900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP09"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="244" mass="28139" checksum="25528C34FE87F61B" modified="2024-01-24" version="1">MLSSFRSLQTASLNDIGWGYPLNDSPDTVFQYNIPLSLQKLSLWRCYKRDVMECFLSQDPLPIISELDLGVVSPSDTEAIGKYLGRLGNNLTSLSLGFSSLDAGGDAEDFYLNCDLSLNTQLESIHFDRFLYFSEYRLTSPWLWISKIISSMCSTILTTICFSIYLPHDQLFESHFEFCWSEMDQFFDQGLVMLPRFQHIQFRICFHSSPELDILPLVFSTIRRELPLCDKHGFPRFVVKDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP17</accession>
    <name>A0AA38KP17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_314452</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MU793366">
        <property type="protein sequence ID" value="KAJ3784724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP17"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="15">
        <location>
            <begin position="29"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="14">
        <location>
            <begin position="304"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3784724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="495" mass="55193" checksum="82D02D447FF41249" modified="2024-01-24" version="1">MSKSKESTSGATAASSFNTTPRGQDDPYQYQTGFGNRFASEAIPGVLPNGQNMPQKNKYDLYTEGMTGASFVAPRADNLNAWLHRIRPSVAHQGFTKLPDNPDLESNFLPLNSKVHVSPTQLAWHPFDIPSDQVFDFVDGLKTVAGNGDPTLHEGIAVHMYLANASMGRKAFCNTDGDMLILPERGRLDIQTEFGRLMVRPGELIVIQRGIKFKVKLPDGPSRGYIQEIFGSHYTLPELGPLGGHGLANARDFEHPLASFDLDQNHWDIVYKVCGEMHSCSQEHTPFDVVAWHGNYVPYKYDMKKFVFVGSISKDHIDPSIFCVLTAKSKATNVPLADFLIFSGRWDVGEGTFRPPYYHRNSSTEFMGMIYGEYGGRSDGFKPGGASFETGFCPHGVSYEEFQKATEAELRPTRVHENTLVFMFESSMMWTITDWAMNRSGKLHKHEPKMWDNLKGQFMNHLEEVEEDLKKAGLPGLGRGSEQVSTNGHGQANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPX5</accession>
    <name>A0AA38KPX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_187010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="85" mass="9660" checksum="60D6EC522BABFEAB" modified="2024-01-24" version="1">MGFSVKGRQSLTAITGFPLLQLSFSSWISVLYIRNINQEQIEVSLSMSDSIPVPTFLLAVALFRLRWLRVWDSRGLSKKWNPGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ98</accession>
    <name>A0AA38KQ98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_428041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793347">
        <property type="protein sequence ID" value="KAJ3785295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ98"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="258" mass="27424" checksum="8F477F6204E6D3DF" modified="2024-01-24" version="1">MASEHSTPTTSLTGKIALVTGSSRGIGAAIAVGLAEQGADLVINYRTDIKAADRTVAKIKSMGRRAIAVQADTSTLCGGKSLLDATVKEFGHIDILVLNAGMMGTHVMEDSDEAYFDAHFNTNVKGPFFLVKAAAKLFPESGGRVIFISSSMTIASQIIPEYTVYTMTKGAIEQMSRLLAKDLGTRSITVNTISPGPTDTELFRSGVSEDLMRYLASQNPNKRMARPDDVAPLVAFVASPAAYWINGANLRANGGYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQZ1</accession>
    <name>A0AA38KQZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_153830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="266" mass="28751" checksum="CEFA4697FAFE98BA" modified="2024-01-24" version="1">MAHSILIEVCIDSVESAMSAIRGGANRLEVCGNLAMGGGTTPSLGLLKAVREAVESFQVPIMVMIRPRTGDFLYSESEMQIMIEDIRIFNENGVEGFVFGVLTEEGRVDVARTKRLVEASFPARVCFHRAFDMTRDPMEAMIDIMRIGGISHILTSGQGKSASQSLEILASLLKATRNSQDQSSSLTIMPGSGINPNTVGHVVNTLLPLGLSEIHLSGGSWMEGGMSFRREGMGMGVGGKGNWGIWRTDEGVVREVKAQVEAMKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR73</accession>
    <name>A0AA38KR73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_35998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR73"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="44"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="647" mass="71796" checksum="7D25DD5613B03420" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRE4</accession>
    <name>A0AA38KRE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_138227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRE4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="380" mass="40991" checksum="F9244754EF9AF419" modified="2024-01-24" version="1">MSTSGTFINQTYDDRDTTDLHYAGGWESPQVGSWNASNVGESGTLSSTEDIRANVTFIFPTPANAVYYYGIPRCCGGLYAICVDCDPNNPIFEMIDAVNVTDDGKNPPVRFSRHSFFVLHIISTSVQVILWSKSFNGLGIHQILLTNQNDSRFGHSQITIDRFELQIPNTAQVVTSLISETTAASSATSSATSSSALATTSSVPVGAIIGAVAGALSLIGFIIFIWVFRRRRKRRSRAVDESQSQGAHMGVTPFFVPSVALSSIKFSNLESGSSSPPKRSKRHKPSAHSASDMSTSVASTSLSPVDNHPATGRLIPQRREIDAGHIPDDFSDSETLPPEYDQIFRRATSSSVGNQPRPPMLTGQLASSGALDSQFPRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS31</accession>
    <name>A0AA38KS31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_348714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS31"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016878">
        <property type="term" value="F:acid-thiol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF1">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="488"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="64951" checksum="8CCF4CAB9324D3FE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT08</accession>
    <name>A0AA38KT08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_381435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794024">
        <property type="protein sequence ID" value="KAJ3779967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT08"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="79" mass="8648" checksum="8B7E243704A332DD" modified="2024-01-24" version="1">MSLFLDSFATGIVYGVVHAAAGIECLWVLKAYPWMVLAGEGQQMSNLSQVGFYVLTLETIPSQDQEQELAGPQTNWPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT85</accession>
    <name>A0AA38KT85_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_261775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT85"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="100"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="131"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="413" mass="43658" checksum="1D3F4F43CAF36926" modified="2024-01-24" version="1">MGPGPKSPEAGISVPIHRRSGLADSNGIFNVDKARVDVIMTVNKHRRNMMNYLSTQGSLPEGFEIKPLLALPVNLLQTLTGTNIKRQSVPLTDENNDELWDGQISIGSNAQEFIIDFDTGSSDLWVPSSNCTDSSCSSKKKYNSSASSSSEAQSGTFNIQYGDGSTVSGSIFADSVTVAGISVTEQHFAAVTNLSDSVAQTSFDGILGMGYSTLSNLGAPTFFETAVKQGVVSSPEFSFFLSPNGSELYIGGTNSQLYTGDIEFHDVNTSPGYWKISDGSISVPSNASVVSGIDTIVDSGTTLIYGPPDAVKTLWASIPGASAYDAEPGFYMYPCNQTLGVSFSWGGKNWNIPDEHMSTGLTDGSGQNCVGAIVGQNIFGSSSPTWLVGDTFMKGVYSVFNLGNNQLGFAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT88</accession>
    <name>A0AA38KT88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_391309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793819">
        <property type="protein sequence ID" value="KAJ3780267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT88"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="360" mass="42884" checksum="8D7AA66ADEEEF51B" modified="2024-01-24" version="1">MSMARRSARLQVKEAANTSDSPQNVDATQSLEHGEQYDEEQEERPRKRAKRISAESSGKRAEKKGIASKQLRRVRGKLGLLARLAKDVPVEVILEVFCHLEPRDLLRLARTSRELRNLLMSKTLKNIWRAARQNVEDLPPCPHDLSEPQYAFLIYEPICHLCDRRVESVLWSFRMRCCQDCASDLSKFPQYDEEFFARLPQEFRSYDILPRDLILTSERWGWTGHNEITARYKAEYETLQTTEERKTWLNRKAKESQQSRDHRFLCAQWMCRRDIERARELDQLRQQRKEDILTRLNDIGWREEAEIIMKSQRLITWRRDSFAQHKSVNQPRKLTEYGWNIIKDELVTMLSNHKEKRLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTF1</accession>
    <name>A0AA38KTF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_70619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTF1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="23"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="358" mass="38005" checksum="322806E7752D543A" modified="2024-01-24" version="1">MVSFTIPKTQTAAVVDHSGADIRIDHQFPVKSQEELLPGECLVKLDCSGACHTDLHAALGDWPLPAKTPLIGGHEGVGIVVAIGNNTANSPVKLGDRVGIKWLADSCLNCEDCRKGREQNCSKAKLSGFTVDGTFQEYVVSFVNHVTPIPENIASDEAASVLCAGVTVYRAIKYSQTVPGDWIVLPGAGGGLGHLAVQYARVRGLRVIAVDTGDAKKELCLKLGAEKWIDFVECKDIVSEIVSITGGGAHSAVVTSANGAGYRQAVDYLRPGGTLMAVGLPGKATLEASIWWTVFKSISILGSYVGNRQDAIEAIDIAARGHVKVHFACRPLKDLEDVYEGMKAGKIAGRIVLDMSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUD6</accession>
    <name>A0AA38KUD6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_346249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUD6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="209" mass="23619" checksum="B8495E8EEB1D8DA8" modified="2024-01-24" version="1">MNHLESIHNFIEALPYIDKNSVPEGVCCPICLVSFEDILEDASAEKPLGGVTMLPSCQHTFCRNDLIEWIQGMHGSCPSCRHVFLDIRPPSDSDSESSDGGEYFPNEEEEEDPYMPDTDDFTEMDEFDFEMEEVDLDMYQNWEPSDIGDEIEDVSLEWGLTDGESFSNSDEEVSLESDPASLLQRDGNIVIRGDVDENLDVDSLNDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUG5</accession>
    <name>A0AA38KUG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_105499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUG5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="304" mass="32407" checksum="7E060D314B43D724" modified="2024-01-24" version="1">MFIGGLNWDTTDEGLRAYFSQFGKVDACTIMRDPTGRSRCFAFLTFEDPASVNAVMVKEHVLDGKIIDPKRAIPRQEHQRATKLFIGGLAGSVTSESMREFFSQFGRVVDSTVMLDRETGRSKGFGFISLEDADVQPFLGFGHLELDGKLIDVKLAQPRYQRETFQEDEQNGGGGYNNNMRGGNRGTTSYSAPAAAAGSSSGSFNNNVGGNASVPFDPQALAALYTRMFQMTNGGAINSTMGGGMNGGMNPMMSMGANMVMGGGRGSGLQGGGLPRGPRGGPGGMGVGPSRQARNQHNYHPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUH4</accession>
    <name>A0AA38KUH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arabinanase/levansucrase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_276232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793499">
        <property type="protein sequence ID" value="KAJ3782112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041264281" evidence="5">
        <location>
            <begin position="25"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="445" mass="48323" checksum="979074F5DCBB45B5" modified="2024-01-24" version="1">MHARLRASFRSLCVSILLVPFVLGASWIVPGAVWTDTSGNKIDAHGGQILQEGTTFYWVGSAYSNNEVPNIYSSTDLLNWTFEGPASTAVEYMYRPKLFTSGGKFYIWGQVNRLVQALESSTISGGYSVYGSAFSLPPDGRTYSDEGIFVDSTGEAYILTSADSNNLQINEINGGSSVSIGTRVTDLGRVRLYEAPGLMKSTGGIYYLVMSTKTGYTANANQFWWSTNIAGPWNGPSGIAPGSSNTYDSQNTFELKIPGSQQTTYIYMGDSWDSQGTAASNYEWLPISVNDGAHTITLQDYAFWKVDVSTGVITTSTTGKRYDAADGLIMRRGFEDPCASCEHSVHNIDPLSNVTIHNIEGTGEPQWVSIHYTVNDPNAGDAYVWLNGEKIRIADKNSRAGKFATVPINLTLKKGNGNVLTFGCHAHAEGSDFVAHLEGIEVIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUS2</accession>
    <name>A0AA38KUS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793465">
        <property type="protein sequence ID" value="KAJ3782607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUS2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="452" mass="49455" checksum="F09F13C15A42353B" modified="2024-01-24" version="1">MSVAEQPSPADHIEEADNIETTTPRNKKSCTVERRPKNSKGVVDATPNSQESSSLDDSTGIIQRRTTSSASSAALLFSGHALTIFATAAQFTPVPYLATLASITSSICNTIQSAQDNKDSLNQLASTVVSLSSTVSATYRLLHPNPATEGQESESFSKDPTLNQHVEQFIDMLKEIENFVKSHISRKFLQRVVSSRSDLNVIQDYKDHLKKALDAFTLQSFITLRETVFKMASQQESIMSSQETVCSALVSLQDLIRSNATGQGQTPQSLTNGEASSADTVLSLSAILPETTEIVGSPVDINNESFGQTHDTMDYLKSYESSEASHSHSLQSNNPFVNLSTSSPSRPLPPFQLPRPQSERSPQVATTNPFENIFNKPAQGNVNVNYISGDYVVNSNVDHSRRDNFGNVYTGGAFMWEGRARDDEEFIYNHSGLGYVAGRRFHHSSQSRSATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVD8</accession>
    <name>A0AA38KVD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_403321</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVD8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="103"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3783927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="889" mass="100565" checksum="9E08ADC5F9D2AD1A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVK2</accession>
    <name>A0AA38KVK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_31075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793381">
        <property type="protein sequence ID" value="KAJ3784332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVK2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="554"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="684" mass="75343" checksum="A73A464CD336AB03" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW76</accession>
    <name>A0AA38KW76_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794027">
        <property type="protein sequence ID" value="KAJ3779963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW76"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="466" mass="52803" checksum="FFC7DC79154B7D2B" modified="2024-01-24" version="1">MGTPKTKPKLITNPYIRELLDNKSAKEARKWMQKKEPTKKEKEDFHKAIKDNEELIQKKWGGGRQDYLLLRNVYQDEIGAAENSITLTQEQLDELTQPVDEDGNMIEDTEEETEKPKRKRKRKSRKSSPIEDEDMDMTEESIADLLINANIDDEENETTVLTPSETTSKTPFSLVRLTTTAHPIIEREESPAVELKSRSPWTEMPALQPIWPPLPTTCERKVSEVETLVRSFDSPILVTGINYGGNTNSIEHHQKAIRHILELEEGELLFAKAVSNKGRSPWFIFSMPSERARRRVLNVGAIMFTKKGNPRGLSFFRELLGVERIQLKNVIGVHPDDETFVQQAATTRWPEATITVHRTIGGTSPTYLSDKLIIKATFIADQPAVQFLMDKAPLLAPTKSRQHKTGNYNWQLVVASPCFRCQALGHREEACTYESWRWPLKAHHGPPSSGPAKGGRGGYKGKGRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW84</accession>
    <name>A0AA38KW84_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_391394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793989">
        <property type="protein sequence ID" value="KAJ3780008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1194" mass="135928" checksum="4239BE1B7965C62E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXZ4</accession>
    <name>A0AA38KXZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_318071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="MU793457">
        <property type="protein sequence ID" value="KAJ3782738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041293803" description="pectinesterase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="184"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="407" mass="44019" checksum="817B29DD6021681D" modified="2024-01-24" version="1">MPRLLHLSFLLILSLFLTLSPFLSLAVSALSPQFLPCQIQKPAGESPLEGCPAGTIYVSANASDPYASFIKVQDAVESLTDDGNLAVILIGEGQYFEVVNITRTSPLTILGQLPSSYSSVSISTPFANPSHPNLVQIFNTVFVENGIDDAASAVLTVAPNGAAALIGAGTTGAPPQDAFGNVDFKMYNVDIQNRASLTFAISQALATDISYANASFYGCGFSSFQDTWYTGKNASTYVVDSVIFGQTDYLFGFGTAWFQNVILAARGCGGGTVAWKGTNSSLTERVLQYGAYISDSKIIRSPDANATLNITDDCYLGRPWNDWAVTVYLNTFMEDIIQPAGWEPFDSARPTIMNTTFYAEYNSTGPGGNTSNRVSIEHLLTAEQAKDFTMDSVFLEHPTWIDYDYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXZ5</accession>
    <name>A0AA38KXZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_346432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXZ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="27"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="478" mass="53740" checksum="6D5CE26AD79D67EA" modified="2024-01-24" version="1">MESEIGQPWTQDQLNMLNVRKAQKQLKILIVGCGLGGLAAAYALGRAGHSIIVIESSTSIGEVGAGIQIGPNLSRILIRWGLEQRLKSVSERDKPTWFTFHRYDTGEVIGMSRLEGKLDRDHGAPWHVVHRADLYEMLLSKASPYMNLRMNSRVTSLNFDDTSRPSLTLQTGEVISADLIVGADGINSVVRSHVTGQTKIPLSVPTGDLAYRVVLPTRTFTDDPQLRFLVEEPRIRCWIGPGRHIVGYCIRNRTEYNLVLVKPGDGHSYSWTAEGDLKEMRNGFNEWDPCVQKLLSKADSVLESRLLICKPLETWIHGSGRVVLLGDSCHPMLPYRAQGSAMAIEDAAVLGNLFSRISDTSQIAPLLDAYESLRHARVTATQEASARNRTVYHLPDGSEQIQRDAAMKIAMEEEISNYERFKNGYSPSITDQDDNPNAWSDKSKNKEQFDYDPDNAVEEWWALNRDRIRLPEKIHYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYK6</accession>
    <name>A0AA38KYK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_377465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="249" mass="27329" checksum="87DAD64AF7E62602" modified="2024-01-24" version="1">MSDKALDQDRKLLQVPQADIPIKRRVQSKARKFSGASRKRLQRYSTVQVRYKPYSNQVPSCSSYSNFNNNNVVDSERKSDTPHDYLDDWLNDAHVRRLGKTDLAQSRNNPPSLPHQWESPPPPRTTPLAADPGKALPKQPSSDQDVPEGGDGDKASEVPNSPSSGSSPLGQAKSGSPKASQTQNVPEDVGSGHTALQLLVQAPGCNNPIILNFQMHNTIHIAYNWNNAQGDVNHNTNNDGSSHASFNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L209</accession>
    <name>A0AA38L209_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_278080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793594">
        <property type="protein sequence ID" value="KAJ3781162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L209"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="149" mass="17615" checksum="D3534ED43A17E202" modified="2024-01-24" version="1" fragment="single">MSLHILPLHPLFATETLSGSAEAEVLPYESIPRSKQARRIEQRLDSVRTFLHSLARPDDLSDPQFTSFIRYSQQFFVDIDERLWRKDEQGHHCLVIPQTRRIPIMIEAHEKTGHKGIWATNSSIHERFWWPRIIDDVKWFITTCHICQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L212</accession>
    <name>A0AA38L212_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_379813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793592">
        <property type="protein sequence ID" value="KAJ3781177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L212"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041457930" evidence="1">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="211" mass="23720" checksum="C016BA74951AC2B4" modified="2024-01-24" version="1">MRPTLSLSLLYLLWAFFSSINHLGVIAIPTPPVPALHGPESLPRDPGLVNVPIVLSRGAWRNDENINIRSDEKWSLFVGPYAFRLKNHQTRRVSQLPPSEGTLIGHVTFADAHHRREVWKAMTQIQGAQTNLIYIARALAKLEQLAVHLKFIDKSKYYDVMLKMFRAKGNADGGKISDDEAITKTYAAIGNKLEEELQKKLATKELINVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2N2</accession>
    <name>A0AA38L2N2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_152964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793789">
        <property type="protein sequence ID" value="KAJ3780325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2N2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041421559" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25293" checksum="D786F7B8E2570FD4" modified="2024-01-24" version="1">MSLNIFLTAMFLWPLWISHPMSPRLRSIAKRTLYGASTSLISSMINIAILFLLGGNELGWICLSSCVTDVTINSLALFWLSSSSSLSGDVVQDRFSLPTMDMSALTFVRIDSTRPTAITSAQDTLQPQLGSSATIPEAFFDYIPSVQMTLRGDHENQTQEHQFKTSKPLSHERTCTIAYPDISGSNILPDSHCTPNFSATMPNLQPQTDSESGQHTARVEEEKDICDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L326</accession>
    <name>A0AA38L326_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_362463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793446">
        <property type="protein sequence ID" value="KAJ3782917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L326"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="135" mass="16164" checksum="3CCF7DFB1F54D699" modified="2024-01-24" version="1">MEPGAHLPFHTSARNRQKNLHQMHNFPDGWNPPRKLSREAMEGLRQLYNLDKTKFTTPVLAEKFKISPEAVRRILKSRWEQPKEKRAKQAEKDRQHMLLNRLRDKLRERKEVEEILQAKRGRAWGVDTKDKLTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3P9</accession>
    <name>A0AA38L3P9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_359183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3P9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24101" checksum="B06178A653E71D15" modified="2024-01-24" version="1">MLYDESSESDTDSEYEESLAEDEDDAQYISIPSTSPFYHPPPKIRPCAYGFCDVSFSCDAVAEEGSFQMQPPTLFNDSWEDGELPEPDIVHEKRSQLSVPGISENNLCLMRPLLTSSEVWELASLKPLPDVPQGIELEYDYDSDSESSCCNSNDGAEARNNVYISKSPVCAIAPPLDSRLVTPFVDYRRRNSRASIVSKSSFRAHFFKKETLAGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5U6</accession>
    <name>A0AA38L5U6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_353270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5U6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041230755" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="82" mass="8514" checksum="E20FB8E9AFDE2F1B" modified="2024-01-24" version="1">MMITRVIITSIFFVAAGISNATPMPEPAPLDPGLQRVVAQKNGMGVVDSTKSAVNSALHYSEISLFAVLVPAIAANAASLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6B3</accession>
    <name>A0AA38L6B3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">YL1 nuclear protein C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_344645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6B3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="18708" checksum="ADD76F8804758C05" modified="2024-01-24" version="1">MPPKNLKRKATATDGTTTPHVPSLAEQLSYLYLPRPFKNPEYAKNLNRRAKNLKNVMGQERERERADREKRRLEKMEKDAQDAMDVDEKEVVEDEAPSYLSIEAPPSVLPQKHYCDITGLEAPYTDPVTGLRYHDKDVYALIKEMSASTAKEYLSARGVNSIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6C1</accession>
    <name>A0AA38L6C1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_384412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6C1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24728" checksum="FBC178A65B568819" modified="2024-01-24" version="1">MDVTAKFQGSIPHTLHSVSPALAALHIRRIRKLSTAPTDPDSEAYCCAKCGFYLFAGDSSTRVVRVEKNNKRQRIDVPTRTSNSNSRTRARQSTCLQCGWVNEFSLDREPASLFPIRRSSLCSKTGDVEQPSIVAVKSIQKPKDAPVESRALSSRSNVQSTSSQLPDPPESSVPPASTPVPAKKSKSRPKKKNGLHEMLAQNRAKEEKAKNALNGGQSSLAAFLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAW9</accession>
    <name>A0AA38NAW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_337934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794684">
        <property type="protein sequence ID" value="KAJ3779536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3779536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="153" mass="16588" checksum="C70786B37CA8090B" modified="2024-01-24" version="1">MKRKIMSCVICGTSKGAIFDALKIWWVKRKKKSLPVALLVSASALASPIAPQPMDGKLSSVPYDNINMNCIQPPTSWPENGTICFKDVFMTYRPGLPNVLHHMNIDVGANEKIGILELNLKSPGGAGKSSLVLTLLRIVNFEGMITIDGYATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBN9</accession>
    <name>A0AA38NBN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_365863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="MU793531">
        <property type="protein sequence ID" value="KAJ3781711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="201" mass="22648" checksum="C5E1E2A7BB4C7348" modified="2024-01-24" version="1">MTYTVFGYGSLIFKPPPHVISEVHGFLKGYVRRFAQKSHDHRGTPEKPGRVVTLIHKEEWAAFSASDAFPDEDIVWGIAYTIDPAFEKEVRGYLDYREKDGYTLETVDVWGVESNGQETIVLHGVHCYVGRNDNPSFIGSEPLDALAHKIWESVGPSGPNKEYLYNLVEAVRKLAPESHDSHLYALEKRLRALDCLSDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBP7</accession>
    <name>A0AA38NBP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_336084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793525">
        <property type="protein sequence ID" value="KAJ3781771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="159" mass="19083" checksum="B499C621E89DE3F8" modified="2024-01-24" version="1">MSARRTTYKLRALYASRRARSTSLADGPGYLYAFVDRGRYWKLGMTSNFKRRKAQWDNECPCAHRRWLPPIRVTRRRRAGHLLLEIKSIDRPKRYCPHCRRTHIKIFIFRGQWNWTWRIVIRPLLLRVAVEQSHYAHTADVSRHPDANDNIDIQMSRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBX3</accession>
    <name>A0AA38NBX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_83834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793487">
        <property type="protein sequence ID" value="KAJ3782281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="103"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="268"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="512"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="661" mass="73067" checksum="7CCA4FEB6A475CCF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCP7</accession>
    <name>A0AA38NCP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_22868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793368">
        <property type="protein sequence ID" value="KAJ3784666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="350" mass="38354" checksum="4BB5FECAD8B333A3" modified="2024-01-24" version="1">MSFFGTSTTNASATAEKDIEMADPPTDSISSMSFSSQADFLAVGSWDNSVRIYEVSSGGKTTGKAMYQHQGPVLSVCWNKEGNKILSGGADNAGRMLDVQTGTTTQVAQHDAPIKSVKWVDAQSGILATGSWDKTVKYWDLRASQPVASVTLPERCYSMDVQYPLMVVGTAERHIQIFNLSNPTTAYKTMQSPLKWQTRVVTCFTASTSSGFAVASIEGRVAIQYVEDKDSSNNFSFKCHRRDITPNAKDQSMVYAVNDISFHPVHGTFSTCGSDGTIHFWDKDARTRLKTFDAAPGPITCSSFNRTGSIFAYAVSYDWSKGHSGMTPGHPNKLMLHACKDEEVKKRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDJ9</accession>
    <name>A0AA38NDJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_385913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDJ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="483"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="695" mass="78798" checksum="43B4929E53577B75" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDM7</accession>
    <name>A0AA38NDM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_415914</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="7 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="14 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="10 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3787486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="460" mass="52101" checksum="055597470B5D2BC9" modified="2024-01-24" version="1" fragment="single">MSRAIPQPPGYPFLGNIFSLNNGQILTPFVDVPAHGFHELARKFGEIYQLNLLGRKVIFVSSYALVNELCDDSRFRKSVGGALKETRNLLNDGIFTAFDGEISWNVAHRLLVPAFGTPLPVSSHPHSNTLNINIMAGALRVRDIMPIDLNIDPTDDLTRVALDTIALCSMSYRLESFQSDSQPPFVQTMVDFLQECNNRANRPKIVQMFLNATNGKYQRDIEQMRNTAKAILQDRKANPTDRKDMLNVMLRGRDPKTGAQMSDESIIDNSVLTVFLGHETTSGTMSFALYYLLKHPEVMKELQSEVDNVLGDQPAQLGDLTRMQYLNAVIRETIRLQPTAAIRAIYPLEDTVIGGGKYFVMKNEPIALQIWDLHRDISIWEEFKPERMLKENFELLPPNAWQPFGFGMRSCIGRAFAWQEMCLVLSSIVQRFDLSLVDPSYELQITQAITIKPKDFRILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NEA1</accession>
    <name>A0AA38NEA1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_344531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NEA1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="587" mass="63197" checksum="CDDE3D31359233C9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHJ9</accession>
    <name>A0AA38NHJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell cycle control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_125205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793621">
        <property type="protein sequence ID" value="KAJ3780962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHJ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="404" mass="44924" checksum="E76168F809569E01" modified="2024-01-24" version="1">MGLFQRKGSETDESSEDKKEKGGWRRPANTAFKQQRLKAWQPILLPKTVLPTFFLIAIIFGPIGGLLIWGSSLVSEMTFDYTDCETLTPSISNTSLSYVELPSSKYSYHLSSSASKNVDINAPVYAFLNNSGNSQDFDVFNQQQCIIQFDVPADLSASVFMYYKLTNFFQNHRRYVKSMDSDQLSGKGGSASHLNSGDCKPLGSLNNISIYPCGLIANSLFNDTYSNPVLLNPSNFEATNVTYNFSSENIAWPGESKKYVSTPIGNGYSSVDEIVPPPNWQKRFPNGYTNDNIPNLATDEHFQNWMRTAGLPTFSKLYGRNDQDAMQKGRYMITVGLNFPVIPYKGTKSIVISTVSWIGGKNPFLGWAYVAAAALFVLLAIAGTAMHLIKPRRLGDMSLLSWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHT8</accession>
    <name>A0AA38NHT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_365361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793518">
        <property type="protein sequence ID" value="KAJ3781862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="286" mass="30768" checksum="8F799BD9B4E6CBCA" modified="2024-01-24" version="1">MKSSSLLQLRLTSLNKDLADLQAEHQATLTELETAYMDLRAVVGLFNPGLEQPATILVPSNPSSEESMDDYTSLSSEELVNDIFTDEEHVEEREDDPNERESKPLVAENLRIISVKSMAPIGESLGPVAGQSNKVNGVDPNNSEKKTDMPAPLQDGASACDVPTMNGSRVGSMSGDYNESISQSNGTNVVISSSKQPSSVLTTSIAAESLRDSNVPCASATSNIAPSGLEASSTHDCCASSTWLEFQQHFHRSSSNCNLGSEYKLKCCCSQVKCNLIVNKLRLSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIK5</accession>
    <name>A0AA38NIK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_334271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="338" mass="37915" checksum="E96E6B2E2F6FE5C2" modified="2024-01-24" version="1">MPHAVPPLPTPSPAFSRQTRSQTSQPSRTPTPSSSLTTIHTPSSRHDRELERLHVENARLRADNAGLMEESASLKAQRDAAQVHAVFAGQQYAVYKHRLHEKTKRKEGSKRVSTSARVLTSMQGRLEIAADAAKKAEKSRELQKKKEKDAQKAREDIVRRAEQEKERTEFSGNMKYMVRSTLVDIAFSLNIETEKATAETLRVHLNAHFEANPELKKHARYLRLFERSRKRKEPPTESNIPSHQPSPTSTSHSSPAPGPSSHHQPPPAPAPGPSSLPPFYQSSNPFAYENPSPLLFQHIHPYPPVPAFPYPMFQSHSPAVFHPHPHSQSHHILNPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIM2</accession>
    <name>A0AA38NIM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793992">
        <property type="protein sequence ID" value="KAJ3780003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="344" mass="39442" checksum="3C0A80C4B8080BB6" modified="2024-01-24" version="1" fragment="single">ITLALLLWEQGGHVDFMLTSDFCKMLQRPGDMPVEWERMKNYEFVFFGGSSDPSNELTKVQHRNLQVLVKNSIQIWPHPLSVKVVLQKSVIHGALSGTIREAGGFAEMIFQVTSLDMGIQLLHKGYVIKRDCSFESRHVFLPKRAPYMSNAGEDATARARGYEDLFRQAWNLNVSGYKFFAIKYNPSLLMLGEVRTFITFGQVIELIHTIPEDPVLKRDEMLHERCHGSLNDVTKMTKPERGRYLDFSQQRRRQELWHLRDLALDNTGTNQLIEFALKVYHKLIDVEESINKTNQFYHGIAGHKVCVRLDIGVIWDCLFMIDKDARAGVPYGVIDGILRGSLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJL8</accession>
    <name>A0AA38NJL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_278284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793612">
        <property type="protein sequence ID" value="KAJ3781039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJL8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="191" mass="21554" checksum="829A9EDDD6441E2D" modified="2024-01-24" version="1" fragment="single">TQKLERRLQIAAAMIRISEALANNEQCDCWTRILDSISQLGTMGMSDDEQILDTQGQHGIVVYSPTFRHSQFDELFNKVDSIRGLEKYLFTRVGRNRLPRIRGYEGIERSPPANLPSSFYQPSYLEAMKKGVVNVVAISKEKTTIPRCVLRQSLENLDSDSSQKLTDTFGLQPIGISWSAAQCLVLAVRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJT5</accession>
    <name>A0AA38NJT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase phi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_311591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1130"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1165" mass="130750" checksum="7F01097815EF810A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJW5</accession>
    <name>A0AA38NJW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_366269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793542">
        <property type="protein sequence ID" value="KAJ3781594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJW5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="752"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="838" mass="94917" checksum="614CD570BD0F1C3F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK10</accession>
    <name>A0AA38NK10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_365486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NOSIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793521">
        <property type="protein sequence ID" value="KAJ3781834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK10"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="350" mass="38706" checksum="6E98D4200C641721" modified="2024-01-24" version="1">MTKHSKNNTASSIFSYAEYKKLDYGTKKQRLGHESMRRFDACALCLNRAREPLACNEGHLFCKECVYTDLLTQKKDIKRQKDKLESMKKEAKEEREKAKLAARERVLREFEKGQLGLGVNKPSKTGSGTLTGLENDANEANPSDSLKRKFNFSSSNVESLALEAEEAALRQIEVEQREALKAKLPDFWLPSLTPTYTGKGDLESVKSLEDVKLQTTCRGGNPRHSLNMKSLVPVKFTFETSNSSGKSNSKESDQQAICPSCKKVLSNNTLIYLSKPCAHVTCKTCTETLVRPAKQCIVCDTPLKVPDEGKRDTAGKGDEKFDIIELKREGTGFAGGGMAETSKAGVAFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK14</accession>
    <name>A0AA38NK14_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_408547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793482">
        <property type="protein sequence ID" value="KAJ3782358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK14"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="250"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="320" mass="35065" checksum="6BDEDE360228BC59" modified="2024-01-24" version="1">MQVPGPLKTLFSYFPLYTHPPLNAKENKTLQGPTIWARLSKTNNSADAVLSSDVECLKWQAYLALRGLSGIRVRFDVDAQGAIDGRLPNLHVPFDASATYSWSADNNKKSSTGPIDDSTELLSAPHIVEWVDTKLAHSALDDAWEGYKDEAAKDESRAWVSLLEGNVHAALLLSQPAQSFLESLLAPPSPPSTSLESILVPPPPPSTGFLSLLPSYSFTLFSPFGNTSNTTGSVRISSATKISVFEKYPDAIKALSERLGTDKWFLGSEYPTPLDALTFAYLHCILQSSEAVRKEVTRRVNLVAWELRVRAMVKAAFNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK69</accession>
    <name>A0AA38NK69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_76224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793463">
        <property type="protein sequence ID" value="KAJ3782628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK69"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="528" mass="58704" checksum="F067798AD4C42128" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKI2</accession>
    <name>A0AA38NKI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_288650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKI2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30427" checksum="D845121C05B50ECA" modified="2024-01-24" version="1">MADSWTDGILLKIINVIVYVLFLGSNIYTVAAPSDIYYTGKETYITPAPWAFLIWTVIHILLLGTVIYQFFPTGKRVIIDGISWRLPLLGVLNAIYVNLWARHSYIAAFIFALFVSSAVTHIYYVVKKHHASQSVADELFVHLPFSLYHGWTTVLVILTVFEAFGNNALHEKAGVWTKVLVFLSLFFLEATSATYAFSTPEGDLPASIAICWSLFAIFAHQRSTGFIHWSALAFSILSLVWVLKGSYGLFVRSRGSGGIRLEDPERAPLVGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKQ8</accession>
    <name>A0AA38NKQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_308696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041381361" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="38"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="540" mass="59624" checksum="926E603A592D3C94" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMA4</accession>
    <name>A0AA38NMA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_291200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3786004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMA4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="691"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="735"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3786004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="923" mass="99942" checksum="D9C6BA1B60EC5F39" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NME0</accession>
    <name>A0AA38NME0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_351293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NME0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="324" mass="35839" checksum="D2BC53E5E324E59F" modified="2024-01-24" version="1">MASRVPLIFGTMTMGFSGKNGVRTADPEECQNIIDIFLQHGHNELDTARMYAEGTTEELLSKLDLKGATIDTKVFPVKPGDHSPAHLRSTFLTSLEKLKRDKVRVLYLHAPDRSVPFEETVAEVHKLYKEGRFEIFGLSNYAAWEVAEIVGICKAKGYIMPKIYQVMYNAITRAMEAELLPCARKFGLRLVIYNPLAGGFFAGKVSSLDDPNAAGGRFDAGGSAMGKMYRARYLKDGYFQALENLKIVATEHNLRLTEIALRWCQHHSVLTPEDGIIIGASSASQLQQNCEDSTKGPLPDAVVDALDEAHRIVVASGSVPSYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMK5</accession>
    <name>A0AA38NMK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_309734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="187" mass="21614" checksum="4537DCC7352D8076" modified="2024-01-24" version="1" fragment="single">MLNGKRPQAHTSEACFVFTGTGLSRALINEALSSVIAKPGLTTNVSQTGAFNNPIAQLEYMKELFPPRIFEDPDFEQLRRRIFYWLQGRHRFTAEYMSVVLQNGYRHLEQVLNFYIAALCDFRPADYNGSEMINGNIVWPSKGFEFERLDTEMRDRIKTISHEYLFTSKVSTMLGDNELKYIEFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NML6</accession>
    <name>A0AA38NML6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_349448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NML6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="710" mass="80165" checksum="4D57237190C1A332" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMU0</accession>
    <name>A0AA38NMU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_348393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMU0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="2">
        <location>
            <begin position="130"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="198" mass="22113" checksum="58E1C08DD9E08CB8" modified="2024-01-24" version="1">MPEKVLETPYTVLDIDPHFSRVVRYFRASDYATWAATTVAVPGALLAWEMADPNGLKVNRITLAPGEKLPSGRIAVGNAIQIVTRRMVTGMKVAAFLGFCGGFMLAYQNSSMRFYGWAENKREEEMDFAELSQRAKEGKPLYGESPQSPWVQGAAHRNSVFSQLKFSVFPMFNFVNHPHHGVDTSKYGVKEEAKSEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMW9</accession>
    <name>A0AA38NMW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_136977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38161" checksum="367667E9B6DFDEA2" modified="2024-01-24" version="1">MSTTSLTTQDQLVAPAGFTPILDGQLFEHAERLRDKVVIITGAANGIGKETGVRCASYGAKLVICDLDLVGAEKTVSEIIASGGQAVAVKCDVTIWDDQVKMFELAIEKFGSVDVVIPNAGIGEPGNFLEVKLDNKTGKPQKPNLSTVQVNLIGVLYTVHLAQHYLLIDLRKVDTPTQPLKAMILIGSMASWAGFPVAPIYSASKHAVLGLMRSMEPSLLLKGIRIACITPFFADTGIIPTPLKVFLAGCPLTPVPRIAGAIIYAATHPDPATSGSGYVLPDDGPVFEVPREKFKMGVYKLLDDRLKSVEGIVYAVRLTKDLVKLVAKPVVVTVIGLGLARAFWSNRDILPSFMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNI6</accession>
    <name>A0AA38NNI6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tail specific protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_345943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNI6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041269718" description="Tail specific protease domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="72904" checksum="C66535EB4B0B37CD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNN9</accession>
    <name>A0AA38NNN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_344341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="285"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="588" mass="65322" checksum="53F1259A26CFA2C7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNU0</accession>
    <name>A0AA38NNU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_241779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793558">
        <property type="protein sequence ID" value="KAJ3781445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNU0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="15790" checksum="E60B3F510810046E" modified="2024-01-24" version="1" fragment="single">INIPPQQDPLLEFLASRLMNNGHRAKANRIVARTLLNIHAYTRAPPLPILREAIFALAPSVRLLKHRHSTKTIYRPVALSEKQGIWYAVKWLLDECKGRQGGPMVEERLAREIIKIAKGESKTLEKKLEVHKMAMVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP16</accession>
    <name>A0AA38NP16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_297701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="MU793469">
        <property type="protein sequence ID" value="KAJ3782540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP16"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="78"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="260" mass="29583" checksum="37454C5E5B52E970" modified="2024-01-24" version="1">MLSISLALFRQPPSLFSKICLLRTFSMDLVISEPSPSKIQVLPHNQYQTLDSLTPSTVSASPLDQFHIWFKQVVEDGVVHEPEAISLSTATPSGVPSARMVLFKQLDERGFIFYTNYTSRKSKEMEANPYAAIVFYWREVHRSVRVIGKVEKVSRKESEAYFNTRPKGSQLGAWASRQSQVVKEGEVRERLKKLEERFGSAGDGDANIPTPDFWGGWRIIPTEVEFWSGKPSRLHDRVCYRLKEGSTAEDPKWKIECLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPA5</accession>
    <name>A0AA38NPA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 39 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_272620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041400757" evidence="1">
        <location>
            <begin position="21"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="472" mass="51468" checksum="D1BF9B9400AD071A" modified="2024-01-24" version="1">MYLSAFSVAGLALLPFCAYALTLDTRQTANQITTVNLADDTGTPMHLASGFLYGIPDASEQIADSFYENMGFNYGRGSGAQLAAPARGWIFGLTEFKAGFNRFESAVSNYNTARRYNAKFILLLNDLWGADGTQPAGSVFPGDDGDWDSYDSFIVNVIAGINSNSMFTDLAVDIWNEPDAGTLFWNGNQEQWLTMWSRGYEAFRASLGTTVQLFGPTLAGAPETTNTWWTTFLSQIAGDGTVPDAYVWHLEGSTSDVNDDLQTNIPILDSMLSSHGLATKPIVIDEYGVFAEQCPGGSAWWISRLERYNVPGLRGNWLSGTELHDFFASLLWKPDPTDATATGYWTNGDYQVYQYYNQMMTGHRVATTGSIDRLMDSYATVGTDKVRILIGGRQVTGTWQVTVNSLSSVGLATSGTLDITTFQFSFTGSHTGNVGAPTNLGVVGHTYSDNSVSFPIFQTDTTTTWAFEFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPB5</accession>
    <name>A0AA38NPB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_359173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPB5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="326" mass="35814" checksum="B367C076733EC8BB" modified="2024-01-24" version="1">MSFTEISRFDIMNAQRFDISRRGSCSPETPATSFTQDPLVPASSEFLKSESSRVSLMDAQRFDQSKRCSESSSINGSLSPKCEAASTSAIDTEAVIERLLLEAERLRILDAQRYDPRSRTCSPEPSEHITLGSNPLTLVNHGDSDSGSSYGSASDSPSGYSESISPDTSEGAASVSDASSSIRFANLNEPSSTRAASSWRTGHTVTTRTIIHPVTRKPASFKSSTPVFTPPSSRPVSRKSSRAILRSLTCVADETINVSESDRQKSTAQTMTGEPLTIFITQQVETPRSAEQREREQLWREAMCSLHFGGDWEQMDRRFPPGQPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPE6</accession>
    <name>A0AA38NPE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_314864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="319" mass="36191" checksum="7C62F05AD83D5092" modified="2024-01-24" version="1">MTTLPLVITLEEHYVSPDLLAQRAVDDYSYVLPKLTNLGEERIKDMDAGSVTLQVLSHAAVNAPSSHLARSTNDKLSAAIEHHSKRLAAFAILPMADPHDAADELSRATKELYFVGALINNHLDGRFYDDPFFWPVFERAQELDVPIYIHPTFPSENTKQQYEGNYPESTAYWLGIAGWGWHADTGLHILRLFASGLFDKFPALKIIIGHMGELLPFQLDRIVPMSERWGKHERGLRQVWRENIWVTTSGMFSLAPLACLLHASPVEHIMFSIDYPFSSNETGQKFLEEVKKSGLVSEEDFEKIAYRNAERLLKVRAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPW1</accession>
    <name>A0AA38NPW1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_157406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPW1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041211836" evidence="1">
        <location>
            <begin position="25"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="54"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="328" mass="35490" checksum="06C608D8FDBD5BAD" modified="2024-01-24" version="1">MMMTFSFIYFGFALLLSLPLFTSAAPLRERRSKMLNRRTTYTLSDTYAGDSFFDEWDFFTDPDPTEGNVDYQSKESATSMGLARVENGVAIIAVDSNSSLPLGTNRASVRISTQKTYNGGLFIYDVPFMPVGCGTWPAIWSTSTATWPDDGEIDMIEGVHESTQNQITMHTNAGCSLATGQAITGTVSGTTCESSDSNNNGCATMDTTTNSWGPAFNTAGGGVFAKLWDDTGIKIWHFSRDNIPADITSQNPDPSTWGNPVSFLPSGDSCSVADHFKDHSLIINITLCGQWAGATFSCGGTCQSAVMDPSNFVDAQWKINSIMVYQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPZ8</accession>
    <name>A0AA38NPZ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPZ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="459" mass="51879" checksum="4D319A09705BFFC8" modified="2024-01-24" version="1">MAASVPQEELPILEALVNIRNRLTALKKNRAEFIKPSDVNALYQAVVKQVTKLNDVRDDTTSQSNRLDTTLADVFSLLSLFYLTIGRTKDAPATYSQIASMRQILNHMNESAVYNEADLAPFRRRISDLRQILQRDANESKHPEAILKLLERQLNKCDAIVRALEESLSVISVELVPVHEKLVTIRRKLVALAAKEGSHKADLKPLQEELRKIDSTRVDAKFLGPGGIVPASQAICTSLLEECFEIAQEIKANEESKNVPTSLKPIYDRLSEIRAELEGLVLTHRWTLRETDLWNYSLSLQEIDKMRVDGKFLDSEGNRPEGQYVLLYLLRRCYGLIYRLLSSSEPVSEELTPIANKLSTVKKCLNEVLKYGGLFSPRDLYPYQLALHQIESRRKDGKFIGADGSIPEGQGTIMAHLNECHELIEMLKEAMDEGEFDEDEDEEYYDDDDETVSGGGQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ03</accession>
    <name>A0AA38NQ03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_348443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="300" mass="33320" checksum="F4C1FF17A39AFB9B" modified="2024-01-24" version="1">MEASAKFSSTLDTPLVGPFAVSKNTSNPFGVVSRPQNDHGASHGDSNQTVSSKTSLIHNLVASMKTEKENKQSFAQPISFFYGPRSSPGDLHGNPDRSSSFNNIPAPNSEFSNQRADMHTCLALGSTTNMMEGIQYSSTSEAYPSHSQLAAHINYVPPYHNSIARGGPFALPVYDQEIHPDHRFLLDPSNSQTYPASLDVLEATGYPVNYTNFLRLNSTSATIFSPLFPLTLLYKWLTLSSLTFCLLIFSHPRRDSIRRCQQSQKRFRPRNESTKTNAPTVPLAVPEYIEAKQRKLQLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ29</accession>
    <name>A0AA38NQ29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Syntaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_393641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="300"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="363" mass="40320" checksum="7CFD82983316C9EA" modified="2024-01-24" version="1">MTAIQSVLISGYQERLEPKAHTVYQIEIRGHVRSWSIWRRYSEFDDLHTELVKGTGSPPPASLPPKHKYSILRSHNDPALLEERKIGLETYLRAIISAKEDKWREAFPFKEFLGIPIGRQAGVAGGPPTQFTLTSWLDEHQELQNRLRDVRADINKREALSDQGDVSASHKSNVSAKQKLAGVLSRIGTLGKGLTELAMNGMSEGELQRRTDMVARLQDDCEKLGKMVIVARQFNRSGTDPSAPYSSASTNPASVSDREALLGTTNTFTRVTRVFGQPSKPQETEVTRPLDDVGVFGLQQTQMQQQDGQLAQLTTILGRQKQLGQAINSEINEQIVVLDGLANDVDRVGDKLSKASRQMHRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQD8</accession>
    <name>A0AA38NQD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_392847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQD8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="14"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="330" mass="36563" checksum="7A72C9654FEF26CE" modified="2024-01-24" version="1">MDPAEFTEEEQGRYDRQIRLWGMEAQQRMRNATILVVKLKGTATETIKNIVLAGIGKLIIVDADDVEEVDLGAGFFFCDDDVGKKRVDAAKARIENLNPLVTVEIVPNFDVLDNQNFESTVNGVDLVCITDWDRDDLIRLNNICRRLRKPFYAGGTYGLLGYIFCDLLDHKYISPDRSSPKDAQKNVQVTASYSPLQDALRHRWSALSKRQTKELRPASVFAILSLWQFQSARNRLPLGTQDIGELQQTADALVSGADVNRQVLTTVPHSLIESVAMTAPHEFSPVCAIVGGLLAQDILKTLAAREPPIANFLTFDGNTGGASVCRLSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQP4</accession>
    <name>A0AA38NQP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_260853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQP4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="558" mass="60642" checksum="FA9F1989EFE3686A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR03</accession>
    <name>A0AA38NR03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_43272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041450611" evidence="2">
        <location>
            <begin position="27"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="657" mass="68016" checksum="0411910D4EC99C28" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRB7</accession>
    <name>A0AA38NRB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_383910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041413113" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="47795" checksum="491864CF0498210C" modified="2024-01-24" version="1">MRSTFVVLTLGLAASARPMRRDATALKNGQDAITLNAQYQTLTAASSCTIGDNACVTGKFAQCVNGKFVLQSCATGTICAAIPLDSPNTGTLTTCTTQSDLDSRLAATGATSSSSSVSSSSSSSSSTTASSSLSSSSATGNSSASGSATDNSSSSGNAATASGVSTTTGTTGTTDNSASGSAVTASNSTSTSTSSGSTGSTSTVTAIGSLSSADITTNATENNPDAQSSLTLDPQVIATGFLNNDVQEAGQVASLTSNNNFINYCLTQGDLPITSGKQITTGSCNPAPIGTIPSVQNMPSAKFSNPANGATIPADTAFTITMNINNLDTGNFVNANENYFAAPQQLNAQGQIIGHTHVVIEALSDLAQTTPTNPQQFAFFKGVNTAAVNGAVTADVTSGVPAGAYRLCSINSSSNHQPVIVPIAQHGSLDDCVYFTATNGGTASNATAAAGTAATGAAATASNATVAVGAGKGKGKRSIFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTI3</accession>
    <name>A0AA38NTI3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_430624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTI3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="582" mass="62729" checksum="14DAB555E9B1FF1D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTL5</accession>
    <name>A0AA38NTL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_424720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTL5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="368" mass="40582" checksum="8A2DEF4FE37B3553" modified="2024-01-24" version="1">MAHVQLSPSIGFHPLSTKDAPGFGFGFGTSNMSSQSWATSAFQSAPSSALNQLASTSQLAHSTQRALKRRHEPEETENLRQDEVMDRSPTPERPKRAAPKRLRTVPSSDLVSKEDSLQSDLRRATEDKDIDIGVLLATLPPQSLLPILTSLIKSQPSLKSAILPLIPRPTVETATQALAESSKKLREAYPYSNNAPFSSSTSFGFGFGATSSSGGMRDSYIQSRLRPHINEFVSTFTSYRPYFSYTSTSSQSALSVQTKPHPTEVFFFLSNLTGHVMSQPQLAQNGIEPLLLSKLSEEWNAWVVRVDVVVNQEGGMFGSDSVHGWVQRLNEFAAKDSQFGHVMRGVRDQWIARVGWLVGRTNHQPMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTR7</accession>
    <name>A0AA38NTR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_411196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTR7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041440956" evidence="2">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="186" mass="20317" checksum="DB51B47F15271B00" modified="2024-01-24" version="1">MSSRTIVRVFLAFVLIGVVNAYPVLFGDGNVGFHKRQIPDEEPVQSPNGNIVPYGKRQIPDEEPVQSPNGNIVPYGKRQIPDEEPVQSPNGNIVPYGKRQIPAEQATQAPNGCNIVPYGKRQIPAEQATHAPNSGNIVPYGKRQIPAEQATHAPNGDIEPYSRRQIPDEEPVQAPDGVIVAYKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU84</accession>
    <name>A0AA38NU84_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_424550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3791238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="267" mass="29416" checksum="3C6236D01EE1D711" modified="2024-01-24" version="1">MTGPPAFLSSLLDRYKSPAGQSRPFVTLTFAQSLDAKIAGRGGKQLILSGRESMVMTHWMRTMHDGILIGIGTALNDDPQLNTRYLPPRDPDPSVNGHNHSYNLPRPIILDTKLRFDPHCKLLKNYTEDKGRRPWLICAEPSESNEKKEWMIRRNTLEKAGARVVPLEYDYDTQEYLPISLVLQTIHRLGILSVMVEGGAQVIRSFLLQTVAQSASSLVDTVIITVAPIFVGEDGVSYNAGSGPSSALKHASTAMFGQDTVVGLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZG2</accession>
    <name>A0AA38TZG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide binding protein beta subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_304114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3790019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="38301" checksum="AF8DC3C98A2DF00C" modified="2024-01-24" version="1">MSQSQGDIQERIAAARREAESLKEKIRAKKDSSADTSLRAMAAEVDALPRIVMRPRRALRGHLAKIYAMHWAADRRHLVSASQDGKLIVWDAYTTNKVHAIPLRSSWVMTCAYSPSGNFVACGGLDNICSIYNLNSKEGTNMRGARELSAHSGYLSCCRFLNDRQIVTSSGDMTCMLWDIEAGVRVMEFSDHTGDVMSLSLGPNQNVFVSGACDATAKLWDIRSGRATQTFTGHESDINAVQFFPNGDAFATGSDDASCRLFDIRADRELNTFIHDNILCGITSVAFSISGRILFGGYDDWTCNVWDTLKGERVGVLTGHENRVSCLGVSTDGMALCTGSWDSTLRVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U2F6</accession>
    <name>A0AA38U2F6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytosolic large ribosomal subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_338895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U2F6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="20325" checksum="1560BB3843865C85" modified="2024-01-24" version="1" fragment="single">MRPLTEDESKALFSKLANYIGKNLIHLIDRPDEPYCFRLHKDKVFYVSESSMRLGISVARPNLVSLGTCFGKFSKSGKFKLHITALDYVAQYAKYKVWIKPNGEMPFLYGNHVLKAHLGRITEDTPEHQGVIVYSMNDVPLGFGVTARSTVDTRKLDPTSIIVFHQADVGEYLRDEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U884</accession>
    <name>A0AA38U884_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_257449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U884"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="353" mass="37879" checksum="B438D04F0E8842E7" modified="2024-01-24" version="1" fragment="single">MTCVFSSSETCIKGHRSSACKHTDRALYEIKKKGRPVTQCEHCRELRKTKQVHVKCICQKEEIVTGVEQPSGCSKQGSAAFPNGLPKALEASVAVELLSQGATSDSDLDGCSCLSGDECHCWTPRKVAPRVGKKGKFISELPASTSSPSPESSTPAKVENTSSVQNRLADLRTLLPKPAHDPSASAAVHPVGRFHPHELYSPYGRAHDQVHPNHSIRHTSKSPPTDKPSSALPVTHPFNMQPDIEAWKSFQMTGFASIAGSLCGCGDECACPGCIVHKPNISRTVDASKCGQPDGCRDCMDCSASFSYQSSQGLPPNTALSIYSNPFSLSRGSSIDDWIQQMQSSIPASQLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K890</accession>
    <name>A0AA38K890_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_390581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793551">
        <property type="protein sequence ID" value="KAJ3781509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K890"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="489" mass="52954" checksum="16BA23D0A7D48183" modified="2024-01-24" version="1">MSTLSDHIDRLAHSTRGIISLTASTSGSSRAGIFTRAILTAELGDLIRDIDSSELGLFTITTPSNAVAHDKEMRNQSGVEITRAEFHGATPLRRPTGRRDELKHKELPPEVYAEAALKYIERYQHIRPMPRAHEQVTAVLERLEQTNERIRSMTEQLAQTQATEAPSLQSAADKEQHRIDEVQSRIAALRKHKETLLSQKSRLIIHAEDSISKVGPSKPPPALVDPAEEQFWSTPGPSTKPLQFIDTSSLLDEEAEFGNTSMASSISSPIPSGQFAKARTLSLSPEPLMAAIPQTPSDIEEEIEFGEATPCSPSSMVVSDEPGPPEPESPNIVHTPHKEKRIRINMDIERAVVKIWGAVGDLIMPGNTFNKTNNLPPVAKATISHLQLLSSLTPTVASPTHSVSTVSKGDHAPPTAQQILTAHLLLALISSQSLSLPLNKVKELLAAKASTSGSAAMVSGHPKALYGCVAKRLLKIERGAGGQIVKFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9E3</accession>
    <name>A0AA38K9E3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_236468</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9E3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="70" mass="8116" checksum="EF71F458E7D809C4" modified="2024-01-24" version="1" fragment="single">MSSTASASEKLIPRPYKCPYPLCGRAFSRLEHQTRHIRTHTGEKPFVCNFPGCEKKFSRSDELTRHSRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9Z4</accession>
    <name>A0AA38K9Z4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_313545</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9Z4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="102"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3785124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="502" mass="55925" checksum="B4188A0A4DD6ABD1" modified="2024-01-24" version="1">MLSGREVAQHNSRESCWIIVHGKVYDVTEFLDDHPGGSRIILKYAGKDATQEYDPIHPPDAITSNLPSEKHLGPVQPDTVEKVEILITDEEKERLERIERRPSLSEILNLHDFESIAKAVMPVKAWAYYSSAADDEITIRENHAAYHRIWFRPRILRDVTNVDFSSTILGHRTSMPIYITATALGKLGHPDGELILTRAAAQHGVIQMIPTLASCSFDELVDGARPGQVQFFQLYVNKDRGITKRIVQHAESRGIKGLFITVDAPQLGRREKDMRQKFDAEDPAEVSKAGKDLVDRSQGAARAISSFIDPGLNWADLQWFKSITKMPLILKGVQCWEDALEAYDQGMAGVVLSNHGGRQLDFSRSGVEILAECVEHLKEKRGLSFPNEKFQLFVDGGVRRATDVLKAVALGATAVGIGRPFLYAYSAYGPEGVDRALQILHDEFEMNMRLLGAPTIKDVLPEMVDASNLRSHIVAVPSDSLFNTNYEVMQHALLKVPAKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB79</accession>
    <name>A0AA38KB79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_197198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794241">
        <property type="protein sequence ID" value="KAJ3779773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="172" mass="19146" checksum="31283BCB17374957" modified="2024-01-24" version="1">MMRFDLLPSAVREHKPTMAVIKNKINKELTNNRAAAKALLLKSLGDFSPGINEFSGPYIPIVKLTNMLLSEICGASSKLTVTLPRVARVAFLRNQYVCDATIAANGGKVGSGFWDNVDTALRVVRETHKEDSIKITQVFTRILMEDRATYNDFESDENLDRLAEVLESDVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBZ7</accession>
    <name>A0AA38KBZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_238712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793642">
        <property type="protein sequence ID" value="KAJ3780853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBZ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="84" mass="10176" checksum="899609C6F54E88C0" modified="2024-01-24" version="1" fragment="single">FKKRSQRFFLQNDRLWLAPKVKQDRLPQLVIEDPNKRMDLLAAAHNEVGHRGRDAVYKHLVERFHWLNMHDDTTFFIRSCIECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCB7</accession>
    <name>A0AA38KCB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_336328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793554">
        <property type="protein sequence ID" value="KAJ3781483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="38703" checksum="CE6097397D74C12B" modified="2024-01-24" version="1">MIFSDLLYLSMIPNSVPATLTSRPFPRLCALSAVMFIPADSNCNIRAIDCSNVTLEMGDLGAERNGKSEGTAKLVIRVNCGIKLWRVSPPPGIEQFTQYSGLLPSTKYNGELLPKHREEFKNSLDKSSKDSCGSSQLQTWKQVAAQKDALKVWRIWTAKGYAVQVVIEMDVGMGQGKILNTCGCAEPVEVNSREKVHAQSGEVLNSVKFQKDSDFMILRQGLALDFPRAVFIILVPEYIGNTRDDTLCPLLLMALLWLSSTFSLEGGIQFRCIEQVSKQRQFKHLWFLKNSTVVHDKHVKISPNQVLASDRASEVTATSSWMHYAYIPEVKQSANTKELSLTWARGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCL1</accession>
    <name>A0AA38KCL1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_276318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793502">
        <property type="protein sequence ID" value="KAJ3782068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCL1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="379" mass="43026" checksum="38208F03E1B3EF9E" modified="2024-01-24" version="1">MSLFQQQILHDALALSTPVAGADDERLLIDTLVNARARKDNYKNALNSLHGKNGHSVILWKDFYLEWKDKIDMHVSVSLKNKGIPDPLPMIKVAKKPTPASSGTNLPSAKNGHRSTINSITAHAPSYNSRLPAPNAEVKIPHPPSRSPSPPTKVVAHGRGNKFTEEDREFFIRFIQWRLRCDPNLTRNDLCDQLAEKVPHHTSQSWAAHWSNNHDLPDKILAAAYEEAEGYDEDTEDESSEEVVQPSRTRNPRYYKESSVEEDGQDDQDADIGDEDDDFVLPSFDESAMGKGGDPFTDADFALTARYIASFDDFAKTSTRQRWKPWSQRYPQRSDKSWAEYYRKQERGERLHQLLISSRRTDLSRPSCSCRKNQKSGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDH2</accession>
    <name>A0AA38KDH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_368508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793651">
        <property type="protein sequence ID" value="KAJ3780806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="286"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="563" mass="62075" checksum="C9BB91A60311C742" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDQ4</accession>
    <name>A0AA38KDQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793575">
        <property type="protein sequence ID" value="KAJ3781301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="385" mass="43046" checksum="112BC6A1A53EC538" modified="2024-01-24" version="1">MVTTPNSNQTSPSPSALFKPAQVGKMSLKHRVVLAPLTRMRANAAHVPHPIVTEHYVQRGSIPGTLLITEAALISHQAGGYGHVPGIWNDEQVARWKEVVDAVHAKGSYIYLQLWAIGRPSVPGKPGMEPDFPYDHVSASNIAMTPDDPHKPRPLTHSEIKEYVQWFATGARNAVERAGFDGVEVHGANGYLVDQFLQDVSNDRTDEYGGSIANRARFGLEVMDAIVKAVGAERAAIRISPWSTFQGMRMKDPKPTFRYFVEELKKAHPTLSYIHVVEPRIDGFEIRTDLPEWENNDFIREIWTQEGNSRWFISAGGANRENAIQAADEKGDIIAFGRPFIANPDLPYRLEHNIPFNAYDRNTFYVPDGNTPEGYTDYPFAPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDV1</accession>
    <name>A0AA38KDV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_428649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="45057" checksum="85F313A9BBBEB779" modified="2024-01-24" version="1">MQLQHISNLPAAGAPYFTPAQSLVAGTALIPQPDGKIIPKLFTPLTIRDVTFQNRIFLAPLCQYSAEEGHVTPWHLAHLGGIISRGPGLSFVEATAVTPNGRITPEDVGIWDDSHIAGLKQIVDFAHSQGQKIGIQLAHAGRKASTVAPWLQSNYPATTVVGGHNDAVGPSAIPYDEINQIPKELSKSQLDEIIISYAQAAKRAVRAGFDVIEIHNAHGFLLHSFNSPLSNKRTDEYGGSFENRIRLSVEVVDAIRTVIPEGMPLFMRVSASDRMEEIDVPSWTLADIIRLAPILSAHGVDLLDVSSGGSSLKQNLQDTTAHQKFSKEIKKSLTDVGDPMLVSTVGGIKSAIQAEGYLQDAVADVTFVGRQFQRDPGLVWRFADELGIRVYVAVQMWWPFYGRASRGSSKIQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDY5</accession>
    <name>A0AA38KDY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_365675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="MU793527">
        <property type="protein sequence ID" value="KAJ3781751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDY5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="379" mass="41594" checksum="CC5AE758E467927C" modified="2024-01-24" version="1">MSTSKVTETRRPITYFDVSIGGSPIGRIIFSLYADLVPKTAENFRALCTGEKGIGKSGKPLHYKGSGFHRVIKQFMVQGGDFTNHNGTGGESIYGEKFEDEAFPVKHDKPFLLSMANAGPNTNGSQFFITVAETAHLNDKHVVFGEVIRGKSIVRQIEHFPTASGDKPTSPIVIEDCGELSPDDPSLTVSPVAAEGDPYEDYPDDDDHEVSNPQVAYDIAKTIREVGNKLFKEGKTDLALAKYQKSIRYLDVHRTLSDDAPPELADSYKALLSPLLLNSALAAVRVQPPTSLNADIALKCASRALTSLELNNADKAKALYRRAIAHTILKDDGEAEKDLLEASKLVPDDQAITGELARVRNKKKEKRDKEKKAYKKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE20</accession>
    <name>A0AA38KE20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_365147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793512">
        <property type="protein sequence ID" value="KAJ3781931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041245199" evidence="2">
        <location>
            <begin position="25"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="118"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="431" mass="44936" checksum="9FFFE152A3AD0EC0" modified="2024-01-24" version="1">MFFFLYDSLLLVCLSFSFYSSASATNVASYLARRTSSQVQSFTHDFNVALGVVLTSREKLQPQVHLTTGSQTVFCKSDAGATSAGSNSSSSSSSSGSSGTTKSTGTSTNTASAAGSSSTGVAISTPYRLVEEHSGSDFFDGWTFTDAADVTTHGLVDYVDQGTASNNNLTEITSGGTAIMRVETTATVTGNRQSIRITTNNVYNSGLWILDAVHMPTGCGTWPAFWTNGPNWPDGGEIDIVEGVGDNTNDQATLHTLEGCSLASSSSSALGITGSVITSTDCVSTGGGCGIRSSSTVSYGAAFNGNGGGVFTMTLNSSGIAVWFFERSNIPSDITSGTPLPSLWGTPFAWWSSPTCNVTEFFGYQSTIFDTTLCGDLAGSVWSDAGAPGQEQSCATRTGVSDCDTFVQNNGAALQEAYWEINSVKIYQIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE82</accession>
    <name>A0AA38KE82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_429570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793488">
        <property type="protein sequence ID" value="KAJ3782261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE82"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="337" mass="37308" checksum="57E6B423BB4EA6E8" modified="2024-01-24" version="1">MARDRLAALRAQQQGGASQMSSNSYPTQASEGGGGGYQPRRANPYAQQDGAYEMADVKDSTANLSGGSDDMSSFYAEISSLQDSIRTFNENVTRIGELHSRSLNNTDDVASQRNAAQLDELVADTSALSATLKRRIKALERQAGSGRDGQIRKQQTALVKSKFVEAIQSYQNVEQQYRTRYKQRMERQFKIVKPDASPEEVKAVVNDDSGGQIFSQALLNSNRYGESRAAYREVQERHEDIKRIEKTLGELAQLFNDMSVLVEQQDETIQNIETTAATVEKDTEAGLNYTEKAVVSARAARKKRWICFIITLIILAIIGIVVGIEVAQHVNTNKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KET8</accession>
    <name>A0AA38KET8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_268593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KET8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="76"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="563" mass="63677" checksum="0DF2DCAB554E99AD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF84</accession>
    <name>A0AA38KF84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_46879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793408">
        <property type="protein sequence ID" value="KAJ3783686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="352" mass="36847" checksum="E10432FCE41EA30D" modified="2024-01-24" version="1">MTTSTHRPQHHASLDSHLQSNARHLRAPSPRQSLDSHLDAQSQWALRNTPSPSFSTISVPSLSPNRNSWGAGTLPRPHSSYGSSGLVYGVEDPSVPYHAASNNLPIPGMNLSVSAPSHKLAFDHSNLYTQGIQESSSASFAASMGGLSVDSVGGPVRRHRSMTPSLMRGVDGSFVRRPTSGGGSGDNMAVNAYHPYASSSRASSLSRGGGSVHSSPSGHSLPLPIVGMQRSESRASNLSVEVSGSDHLQQARQMLSRPGSVDPNASDAYPGAAYRTESPGPFANHLSTGPGSVTDSPATFVVDLPRHSSYQHPSHAATSPAQFGISGADKQYSMQGVNSGGGNFYPHHVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFH5</accession>
    <name>A0AA38KFH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_358961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793390">
        <property type="protein sequence ID" value="KAJ3784106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFH5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041433545" evidence="2">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="229" mass="23501" checksum="AEA6AD64491E16F7" modified="2024-01-24" version="1">MQLTFSFLLLSFAVATYARPIDPIPQARDELSSSIPKTPQATGSYVTLADRYVVHSMTTDSHSTATIPPSSSTAAAALSTQNTGRLVLSSATASALPSAGAVPNDSGMPLSKRLLQEAAQSLSNAAGDFQNATNGFEDEKHKYTEPFTDAGAAFHNATSDAQEGFENLGDGMKNGTANLANGVKNSAEDSVHGMENKATGVVNGVKEGAQGAANGAKSGWNNADADSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH29</accession>
    <name>A0AA38KH29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_350787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="295" mass="31672" checksum="198DB980C39715EE" modified="2024-01-24" version="1">MITLNSDNVLNPTEPEGNFSALIQSFAMIIVSEVGDKTFLIAAILAMSNPRLVVFAGAFGSLVAMSILSSAMGHILPTLLPRRWTQLAAGILFLVFGTKMFVEGRQMKAGNEKIQEEMKEAEEEIEEDEARHEGLQPPALENGGHLVPLGVIEGGRSPVFASKDSTLRPKSKPKRSFVEGARNFCSFFLGPVFVKAFALTFLGEWGDRSQIATIALGAAHNAYLVALGTIIGHGCCTAAAVVGGKYVSTKISAKHITLGGAVLFLLFGVLYLYQVFMDTTADDVSIPIINHPEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHA8</accession>
    <name>A0AA38KHA8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_349529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHA8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054000">
        <property type="entry name" value="MLKL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22215">
        <property type="entry name" value="MLKL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="1">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Mixed lineage kinase" evidence="2">
        <location>
            <begin position="278"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121535" checksum="DDB65CC2A10F846C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHJ3</accession>
    <name>A0AA38KHJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_138412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHJ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="55014" checksum="7297C954C1602872" modified="2024-01-24" version="1">MYAQAVPQQRPQSDYSQAQEYQPDAGRLMDRRQYQEAELEYDDEDAGYTPPNDPDDFYAGNGTGSRPASTYMPESYPPVGPGTRSIATQSTRGPSPPPGPILDHSHLRPGNHAALLSHERTLELYRTNAKKTQDPDIQFEFAVFMIDASKSMPIPENTPGNLLQVEKALEKREDLIKEAMALLKRLADRGHPASQYFLADCYANGIGTPKNKQDFDRAYPLFVLAAKHGHPDASYRAGTCCENGWGCRRESAKALQFFKKAAASLHPGAMYRLGIAELNGELGQSKSPKEGVKWLKRSAEHATAEFPHALHELALLHERGIDNVVFVDYEYATELLAQAAELGYAPSAYRLGECYEYGKLGCPQDPALSIHYYNIAAQQNHRDACFALTAWYLVGSPGVLPQSDTEAFLWAQKAADAGLTKAMYAVGYFLEVGIGTPADLPQAISYYKRAAELGDKRAAQRLKGSTTQVMHQPGGPGSVLNRGNGDDNSSKSAKDKDCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHS1</accession>
    <name>A0AA38KHS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_346927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="364" mass="39308" checksum="E976FA2EF90E61B2" modified="2024-01-24" version="1">MAPSTRSQSANNTPVRGHSTAASVLDTLATPTRKIPHCSKCNRPRAGHPRSGCPFITPTNEIASDRSRINLTDAMGSMTIDGEETAPVTPARRKGRRSLDSVPPSVPVEFEDMKQILRERRRSEKAAALAPTQTLESLTDSDLEALLLPGDKDVSDDGKGDSGEVGEEERKIVHWKDRIEMLSTGGTRTTRAIMPGTLITPSPWSSFASIPEDSKEGITDIMDSQSTSTSSSTETISVEVVSPSSTSAPHPLARTMSMEERAGFMANLEELSSAKAYVLNRVDLAALKNQTPKGLYTRYLMDESNAGHDVVIVGRDEVDTERLYHTLDADRQRAKYAKRGVDIKSAASGAVVGAVATFTGLAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKN4</accession>
    <name>A0AA38KKN4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_144990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793734">
        <property type="protein sequence ID" value="KAJ3780449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKN4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24207" checksum="FFAEDCDBDEA853FC" modified="2024-01-24" version="1">MRIHFLRLLFVFPNLAVLGSFSAIHAVIAGPLALRTNNQATIEIELIRYPHVGKNPIATQTDQTGHLIPPPGVDEFHKPVAQPIDKHGKEVKPPSVDEDWHLCIGGSCLALIFDVSPQHLKIVTRMLWDDELAEKGYYIGLGKVTFQDVNQMYSVIKWFRKGLVEAKQPRSNLRYLNAIIDWFKSSEATGKGIKDNIQRDVWVAYLKAMNSVGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKR4</accession>
    <name>A0AA38KKR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_437779</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex, at least composed of TIM23, TIM17 and TIM50. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793684">
        <property type="protein sequence ID" value="KAJ3780629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="16">
        <location>
            <begin position="181"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="447"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3780629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="487" mass="55114" checksum="45952C159D09C341" modified="2024-01-24" version="1">MFSAASKCVSRRVLFQSTRYLAQKPPKSPNPSSTFPPPPPPPSATQNHDPNETEASVPSEQLKEPVLTRSSVPSLDFSPPDPTEQRTGASSRDSLSSTDRQRRAFARAAFGLFTLGIGLQVAYMGREWELEELQMKKMTLNNAPAGRWERTKSRYSEMFSYFSDPVMPELLPPRTAAQYPPSAKPYTLLISVDDLIVTSTWDRQHGWRTAKRPGVDYFLAYLSQFYEVVIFTTQYSYTAMPILDKLDRYNFYIEHRLFREHTRSHNGEVVKDLSYLNRDLSKVILLDTHPEHTVTHPENALIIPGWKGDTKDNGLVAMIPFLESIAIYKPEDVRPILKAYQGQNIPLEYAKREAEGKQKHIENWKQNKGSTSNSFGSFFGVSSRSTQNAPPTYLEQKRKEAQQQYLEEQAHIAKNKDYLESLLKHEQDVMAAQAPSNLWEMIETMRGNPKVPDANIPPPPPPPPGMGFMIPPPQPAPVQAQTPPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMR9</accession>
    <name>A0AA38KMR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_273675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793422">
        <property type="protein sequence ID" value="KAJ3783389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMR9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="165" mass="19498" checksum="0BCACF909E7B4B7E" modified="2024-01-24" version="1">MSPTPTLVDRSDGSPVSWKARKACHRSPKVTEAQKCARVAKEPRRKEVLARALRIKTVENSPVNEQQYRVLRMVYDEITKYPKDNWIAIVAVVIHRSFAQVKHWFSNERQKNKSGETIDWHNELGEKIRVRPMAIELCEQWSDEFFENVVMVYNFKSFKLLHWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNP3</accession>
    <name>A0AA38KNP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_333959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="104" mass="12092" checksum="72748FB57A216E66" modified="2024-01-24" version="1">MCTSSSTDGPTAPARITFHYFAINLKLIIKFCFVIQALRNTYEFSHEAQLFVLSRRSGWKISERPQGHNNTSNEEYELPQVPIEPLNYYSLCVRIFYPQSLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNS3</accession>
    <name>A0AA38KNS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_379888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793604">
        <property type="protein sequence ID" value="KAJ3781101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="134" mass="14652" checksum="01568BFD44799B0D" modified="2024-01-24" version="1">MSHTHASGNATARSEIISVVHSATSTSRRQAPVCPTYKPREPRKPQGAVIVLSSEDDDDEDTVTPVKAVTWGPHKIRTVSQRLDSTHILTTTQVPRVPLTQQDVRKDGIGSICIEVISGAILGAVLMWFYLAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNY9</accession>
    <name>A0AA38KNY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_388785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNY9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041415265" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="3">
        <location>
            <begin position="459"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="658" mass="70270" checksum="36635C8F18BDC506" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP86</accession>
    <name>A0AA38KP86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_35070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP86"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ras-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="121" mass="13709" checksum="63AAE075F57A2699" modified="2024-01-24" version="1">MSRALNTTRIIVSSNAEQYRVVEITGAPNGSYIRERILSKMCVPDNSFSRYSIYQSEIGAYALGDALSDSDLFKLCLQYGDPSGSLRLFVSTAPNRPPTRNEPEYPLENGYYSNSRYYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQI7</accession>
    <name>A0AA38KQI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_361354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793427">
        <property type="protein sequence ID" value="KAJ3783276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQI7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="892"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="931" mass="102352" checksum="42D91AC54F9A9FD6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQT4</accession>
    <name>A0AA38KQT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_360315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793411">
        <property type="protein sequence ID" value="KAJ3783606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="250"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="409" mass="44894" checksum="9D297DD50F7C21CF" modified="2024-01-24" version="1">MTKDGVALTDDLSGSNSKSNFQSQMKRKLVAGDVEASSVNVHSTSSAQVESRYSKRIKLHIDIPTSSGTTMDTSLTSTCTRQDDTSSETFSSLSPDSLFDEVEVLSFLPPTSPQPPLQQNEKAALRTAPPIPGLFFDPSVRLSEELAEELADYCMDRYFDVDEGRGRINQIMLFERAASGNDIHDTCPEMPISTGLPLPLRALLNKLSDLLRPPAYPSDIHELLFPSLTSSKPAKPISTSSTTHHEKPKQARQAILNLYDPGEGISSHVDLLRRFGDGIIGVSLRGGCVMRFERVLEEEYEALSKINSYTSHASSSSAESTIPSAADAYELYLPPNSIIVLSGDARYKWTHGIGRRVGDWVVSNGDGDTERVIPTKAEWIPRRTRLSITFRWLLPGADVVGQDEFGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS49</accession>
    <name>A0AA38KS49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_333235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="139" mass="14731" checksum="F0136EFF516462F6" modified="2024-01-24" version="1">MAELTDFIALIATIAIFAGIIYIIYTVTGTVSEGVKSTKDKLKEKGYEISDQGMSVKTSKRMNREDYVDATQRGLIRAMGASSFGSNTTGSVQTPASTSPSATPTNLSAPTLKHRSSSSSTKSASSGQKISLFGKKKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSQ3</accession>
    <name>A0AA38KSQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_394854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18950" checksum="1BA82DCDD7E6CA87" modified="2024-01-24" version="1">MGPTTSNSDLSVSIPSSASVISSLVSASSNVGTSTGLSSVAPTPITSAPSSTFSMNRFPNGVTCPPPNKSDLIHSYTLQQAESGLGNDYLKRKNVIRVRMEGEQFLLQARDVTAVVDWIEGLHSAANIALDLDERPMPRGPLFPRRRRRRPRRTNTADAGAQNVNVTGNTSTAASAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT15</accession>
    <name>A0AA38KT15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_243484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793996">
        <property type="protein sequence ID" value="KAJ3779997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="310" mass="33667" checksum="175563BBA9548A3B" modified="2024-01-24" version="1" fragment="single">RHPASLIDISAHNPQLVRLMGSRVNMDMIDYIARQAANVICIEGESPIIASSVASMPSPNCSYDSVASLPLRDFIGHLVRHAHVQVPTLLATLIYLERLRSKLPTLTKGTTPCTRHRVFLATLVVAAKYLNDSTLKNKHWAQYALFFTIEEITLMETQLLGFLDYDLRFDEEEACRMFAPFMATPAQRASTRALALDKVVKAGRARVQAQKIPESPVESIPPVLLPSRGSTSSALGSTVRTLAKRISNTHLSSSRSQAASSPMYGTFSTVSTLSSSSSDVGSLMEDTGSSSGSSSGWNTSDSESDTEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTR0</accession>
    <name>A0AA38KTR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_253491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793633">
        <property type="protein sequence ID" value="KAJ3780897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13627" checksum="0570FE81854A2858" modified="2024-01-24" version="1" fragment="single">MGHAGLSRIRMMIQKSLVNGMVLVGPADEKLGECDSCHMAKAKRRPFDASTTRETRLLERVHVDLTAGPMRVRAIGGYYYSMPIVDGHSAMGRDFYLANKESNTTLAAMKSYKARAENETGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTU3</accession>
    <name>A0AA38KTU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-guanine(15) transglycosylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_385683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTU3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="2">
        <location>
            <begin position="410"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="555" mass="60768" checksum="C470FC44E8D816EE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVI2</accession>
    <name>A0AA38KVI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_388503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793386">
        <property type="protein sequence ID" value="KAJ3784212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVI2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="155"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="576" mass="62978" checksum="94BBCAD386686AFD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW28</accession>
    <name>A0AA38KW28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_8358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793350">
        <property type="protein sequence ID" value="KAJ3785202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW28"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="82240" checksum="6543FD4C83B6860D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX23</accession>
    <name>A0AA38KX23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_115611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793574">
        <property type="protein sequence ID" value="KAJ3781313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="353" mass="39343" checksum="632AC627663330D9" modified="2024-01-24" version="1">MPVPVQSLPEWPADVEAHPLLVIDYQLLKAGDKEEIARLWEAGTTLGFWYLKNHGAEQDFVAMWGMGEDVFKLPLEEKMRYEQGDEGLSFGYKAVGHYIVDAAGSPDPVEGVNVAKDDALSYPKVSRREYPTVINDLMGPVITPFVEKCVDVSNTLIEIFNDKLGLPEGTLAKFHRRNDFSASETRTIKAPANLTPGKLAIGGHTDFGTLTLLVNNLGGLQVLPPGTTEWRYARPLPGHMICNVGDTLTMFSGGLLNSNIHRVVPPPGSQSKHDRWSQVYFTRPADDTILAPLLESAIISEAYNKLTPERQKSLSPRVTSYEWFTRRQKNYRTKNHKGAETWAENRGTEHGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX46</accession>
    <name>A0AA38KX46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_156671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3787017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX46"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="450" mass="47681" checksum="7D2C4C8257498815" modified="2024-01-24" version="1">MGHHPLIHQHRRSDVFASPTVSGIAGALTVSTGATTATVLAEATNPASNVNPTVDGLATGTNLVSTTPSVSSSSSFVPTAAASSSSSSSGSSISMGTVIGACVGTLVGVLVLVLLALWLYKRSDPAKQRRPNTRAGPGLQPNWNKLGDDDDKWEGMNQKAETAEIAPMEKLTMFKKATPSIRTAYTAKTEELPAFDFGSHPFSQYHPNLAKELASADEPPVPPFTHRTDSAVVSWDGDTVGGASFLSARSNRVSGSMSPSLDIARPTPALTNSVPHRWESAEVVHLEGHVAEVIDPRDAENPFEHHSERRKSQHNPFFGSSSSSLPIAKIDKGKAREITPLPPIPISNPFADDSETMDNMDRTPTRPTFNHQVVGSISSVTSNDRAIQSLIAALDTTPEEVQARLKVAEPSLASDTADSIYTSAGYNSEDEDAEDVTQSFPLPPGSDHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY81</accession>
    <name>A0AA38KY81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP phosphodiesterases class-II-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_306368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY81"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="357" mass="39340" checksum="75F96C303C746B50" modified="2024-01-24" version="1">MDDTGPAFVLVCVGSGGGPLESNLSGYLLKPYNAGWEAGIVALEAGSGQGTLKRLLEQEPDLFRTQSSASRTYSASEIYTFVRCFLITHAHLDHVSSLVLSTGSSAGPRKRVYANKETLENLEGMYNWRIWPNLASYDENDEDFKLLYSPLTPNGKYHSVFPDTSVQIVPINHGTTDLGPYSSSAFFIRSDSHPSKREFLFFGDVEPDSITSSTPKIINVWRKAAPMIPNTLSTIFIECSWPSGRPDDMLHGHLTPEHLRDELVALATEVYHFRRSNSSSSSRPQRKRQKRNALSADELQGLLTGVRVYIIHCKDQSTSVDGPSTREIIAGQVRSLVEAAELGAEILSADQGMSITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYI1</accession>
    <name>A0AA38KYI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 7">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_360768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 7"/>
    <dbReference type="EMBL" id="MU793417">
        <property type="protein sequence ID" value="KAJ3783488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="145"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="205" mass="22869" checksum="10B6D357A7173C98" modified="2024-01-24" version="1">MLQALQNQKRVLRKSIHSVIHSLENIQEQSRAVTAKILLLPEFHSCTRVSCYLSMPSGELDTSEIVTTILASSDKSLFVPKISQNGAMELLKLDNQNDLDTLPSGKWGIREPSYESEAGPRLNAIDAGLDLILVPGVAFDRSMSRLGHGKGYYDRYIARYIASGRPRPLLVGLGLRDQLLDTAVPVEEHDYKMDMIVTPDEVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYP1</accession>
    <name>A0AA38KYP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sds3-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_40603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="866"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="945"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="1508"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1543"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <end position="110"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <end position="249"/>
        </location>
    </feature>
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            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
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            <begin position="327"/>
            <end position="336"/>
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            <end position="358"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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    </feature>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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    </feature>
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    </feature>
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            <begin position="1073"/>
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        </location>
    </feature>
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        <location>
            <begin position="1089"/>
            <end position="1118"/>
        </location>
    </feature>
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            <end position="1160"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1381"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1422"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1465"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1543"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1574" mass="169523" checksum="58A98686D88EC6BE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZY5</accession>
    <name>A0AA38KZY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_241665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZY5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0001228">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
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        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
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        <location>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
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    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="85"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="85" mass="10146" checksum="112CE243B6DB3CD8" modified="2024-01-24" version="1" fragment="single">PDYVPRPENCFIIFRNEWVRRNARGPNPNRSRGKSSAIMQKRMSKRASEAWNALPQSERNHFKTLADQRKVEHAQAHPEYRYRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L094</accession>
    <name>A0AA38L094_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Formin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_373875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L094"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="368"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="585"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="89290" checksum="E4150153250B554A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0C0</accession>
    <name>A0AA38L0C0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_385508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0C0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="2">
        <location>
            <begin position="53"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="518" mass="57440" checksum="1539FF2521C8ACC0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2N9</accession>
    <name>A0AA38L2N9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_389983</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MU793489">
        <property type="protein sequence ID" value="KAJ3782242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2N9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="380"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="551"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3782242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="701" mass="77437" checksum="94C00FD3DF89A935" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L309</accession>
    <name>A0AA38L309_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TEA/ATTS domain family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_378217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793451">
        <property type="protein sequence ID" value="KAJ3782827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L309"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="7">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="408" mass="45758" checksum="34F5C476BC7419A5" modified="2024-01-24" version="1">MSPRSAKSHKPHANYICMSTVEDLSYTPSVEEKNRDAAQIVATGRRSWKTLRGRGEAVWPPHIEAALIEALEKYKPDESRSSKTSGRFSMRNRFISDYIYESTGKQRTPKQVGSRLQQLRDTCKSDKILQLISRRGIEDDAEFGQSAYSQSPSASPSPEKILTQSHNIYRSPMTIWVHLVLERSSWSSAPPVISLVNNEKAMTQVIHLAPKSSLNFFSSSRHGFVDTGLLSHLESMVTFASPYVLEPQCSFSVFMDSPGLPIHMEDWFPDFGNHFVKVLVSSLAPTRFTIVQNICLTPRTSIGPADVSIIYNFTYSMSENTEILLHTMPVYGSAPDFSFTNRPPSTSMPGAVTPSDDFSSHHYSPVMFNSDPTAQYDIPPAPRYDRASSTSWVYGQRYTQHISSSTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3D7</accession>
    <name>A0AA38L3D7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_53327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3D7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="88"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="482" mass="53436" checksum="34670B945A14FC65" modified="2024-01-24" version="1">MSTNPSHILIARNSNNYYSGSRGPNNPSASLSSPTETHVHAAASASGAGISPYLLSESDPEEGAEETDVGEEDIEIDETFTKNAKFPGTVKIIVENTVFWAHKEVLVFASPFFEAALSGNWSETEAEGKEDAEEGQSQRSSQRPPSLITISQSIGPDSETEMRLTFDPVKENDSDADYSRGDALAKLQNSSPSTAVIVLKEERPSTFHDFLKYVYPHLSCIITWNNVEPLIHISHRLLQPSLQRDCLTFLLTHAAGKPIKAMRIAELFEEEELYKESSRFVLDNPGGWSEDEMRSLTQETLLKLEKRRNWFLERVLKIGLTSVAKEYQCCSSCPDPLLCARQLEEKWRQAYHAVFRFGPPQPSMVYRYLRQLEGVSPPLSLTHLACQTTAKAFIATLFDRMFSLGVPRTSSSLNPTNAEVTQHAPLSLGTRVAAAAIAAGGSTAPRRHFLFCTLRQEGTRQRGAKGKRKERGRNSRGGGSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3K4</accession>
    <name>A0AA38L3K4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_45849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793406">
        <property type="protein sequence ID" value="KAJ3783727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3K4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041388774" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17110" checksum="CA42F89E9BEC0006" modified="2024-01-24" version="1">MRLHLACLALLGLAPFMHAMPAGPNSGALMRVHGPPSNQKVNSQGSVPVTVTVKFPPPFDGERFASPASSIESERVRKGMSRLIAILKGLYRDHGELDQGVDFQYVNEFRETQDPSLSKFFKVVISGPFYPCPDISPCHFQVPYDPRKIPKMVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L460</accession>
    <name>A0AA38L460_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_362393</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="4 12"/>
    <dbReference type="EMBL" id="MU793445">
        <property type="protein sequence ID" value="KAJ3782935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L460"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3782935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="500" mass="56912" checksum="208EDCE4243BAAC5" modified="2024-01-24" version="1">MTSPPKFLPSACSSDVHSPLSGSESWSSLIECPADFPEELFDTAVSQLIHHPEYNSTLILRSETICDSFDVSGFSPLIPTLDGFQKSRCIHRKILPRRPGRDASLEQYCTLYNGTSRPSHTVLILTPIFSEKDPLPYYHPRVAHLAFRYIQSHDTESGSALLRIEAIPLPDTPLDQNSRLFRTSLALLETLHRYGWGAMTNYRKRVNHDVLVPREPYQDLYLVMRERHRGLVDTWQEVTDPLKHVFEDIGIATYLMLLWKTTFGNEEMETDMTTGEPWRKWPRPPAGFIDIGCGNGLLTHILTSEGYEGHGIDVRERTSWKFYPSDTQKHLHVHAFNPLDFDNKFFPPGVFVVANHADELTPWAPVLSTLCSASGYLSIPCCAWDFDVRYERSEKTMFPIPNHNPASNLEDFIKTLNLGGDGSNSSGYSMYRIWLATLSAHTGWEVECETLRIPSTRNWAIVGRGHLISKEESVKNVNEIVQKVKERSLFKPRKPEGKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4F0</accession>
    <name>A0AA38L4F0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_361028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793422">
        <property type="protein sequence ID" value="KAJ3783370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4F0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="159"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="637" mass="70222" checksum="EF1456479F1A9328" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4N6</accession>
    <name>A0AA38L4N6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_359924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793404">
        <property type="protein sequence ID" value="KAJ3783790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4N6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="294"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111686" checksum="65747703D9C210E1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4S4</accession>
    <name>A0AA38L4S4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_291210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3786007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4S4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="164"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="425"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3786007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="490" mass="55140" checksum="2D39C097CD1B5AF4" modified="2024-01-24" version="1">MPSSYLAPRSGSIPEHTQLPQSLPTSRNPSFDSSNAHGPSLSRRESYSVVPDAPITPPLSPGQSADIGMEDDADVEDLDMDVDQAEGRTSSTMTETTVDGSTLSPSPAPIMEPRKSREAIDISKIREAQALSRPTGGPEGHRPLKLLEDEEVHLQKSGVKLTDFEVRGTLGSGTFARVLLVRHRSSSDDSSAQNHFALKVLRKTEIVRLRQVEHVNAERYILSRVHHPFIVDLFATFQDSLNVYMLMSYIPGGELFTHLRRAQRFTPDVTRFYLATIILALKYLHSYNIIYRDLKPENLLLDSRGYLRLTDFGFAKIVDDRTWTLCGTPEYLAPEIIQSDGHGKAADWWACGVLCYEMLVGYPPFYDESPYGIYEKILNGHIHWPRGMDTLSRSLVRAFLNPDRTQRLGNMIGGPQDILDHPWFRGVDWDALERREINAPIIPHTSSDDDTRHFLHLPLPPAAEIPGLVKEETSSPVQRFDPIACQFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6A8</accession>
    <name>A0AA38L6A8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_344583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6A8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="8"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="605" mass="68826" checksum="7AA39723406DF076" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6N0</accession>
    <name>A0AA38L6N0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_432801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6N0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="252" mass="28641" checksum="EC5CCA4259B11516" modified="2024-01-24" version="1" fragment="single">MPKSRKRKVPITSTGSTYDASSKPESGRTVIRRFHVLLKLQAQLQKAIVYDPSKKAELVNVENELEELGGLKNYQRMSAIGQGTDRGGGSEKMLIRWLKDKELHKTEKKLRLLEVGALKPDNYASCSSWIEATPMDLNSRHPSIIEQDFLLLDQEQNHEKWDIISLSLVLNFVPEPPDRGRMLCLAYDFLVGGGHLFVALPLPCLSNSRYLNFDLFIELMGFLGFTELQRHWREGGKMIYILFIKKNGAAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAZ6</accession>
    <name>A0AA38NAZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794291">
        <property type="protein sequence ID" value="KAJ3779731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAZ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="596" mass="67930" checksum="EC2F4D9029D8967E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBI0</accession>
    <name>A0AA38NBI0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_300126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793602">
        <property type="protein sequence ID" value="KAJ3781111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBI0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="422" mass="49691" checksum="3EA4F263AECFD882" modified="2024-01-24" version="1">MSTATKPQVKDSYNEADLPQFEPMPWSLKEIRDALPARLFKRDTARGLRFFAVDLVMTTALWTAATYIDPYFAKAEVIEKFSPIGAEVARWASWSVYWWFQGLVFTGIWVIGHECGHGAFSENQWVNDILGFVTHTFLWTPFFSWRISHHRHHSNHASMERDEVYVPKTRSDLGIPPEKEQWEPLDWDELFGDTPIYTLYMLVRQQFLAFPAYLLWNVSGQKHYPKYTNHFDPNSVLFTKSQRGIVMISNAGIAFMIWGVWKSCQIWGAANTFKYYGLPWFLVTHWFIMITYLHHTDPVMPHYRGKEWNFQRGAAATVDRPFLGWQGRFFLHDVAHFHVIHHFFPKMPFYHGPEATDYLKAFIGEHYNFSDKPVFKALWDNYNDCQFVEDEGDVVFYRNKEGKSIRRPTDPYFVGKKSTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCF3</accession>
    <name>A0AA38NCF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_272622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="3">
        <location>
            <begin position="241"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="402" mass="43147" checksum="240015B96CA0B9BA" modified="2024-01-24" version="1">MSGPNSDTGSIRAIDGSSIHRITSGQVVIDLQTAVKELVENSLDAGATSIDVRFKNYGLKSIEVLDNGSGISENDFDSIGRKHHTSKLSAFHDLTTLTSFGFRGEALSSLCALCEDVTVTTATTDKAPMGAVLELDRRGEVKSKAKGVRQHGTTILLTSLFSPLPVRRKELERNIKREFGKALALLNAYTLGPCCGLGSGKAVRFSVANQPDKGYVVTHISLPLPSPAGSSLSLQTVRAGTTALWGPKALNGVIDLDLEFEVPKKGKGKYRVEEDVDLVEDTFKIHVKGLISSPTPIPGSGSTPSSGSSARSATDRQFFYVNGRPCSLNKIQKAINDIYRTFIPSNATSNQFPFIVADFTIPGDAVDVNVTPDKRTILVHAEVELCGRIKVRISPLSRSFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCP6</accession>
    <name>A0AA38NCP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_293823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793368">
        <property type="protein sequence ID" value="KAJ3784651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="38204" checksum="1D228175C5EFFD9C" modified="2024-01-24" version="1" fragment="single">MNTPQHFALPDLFAVCPLEGDVNSHYKEAGAESADWINSYDIFTDRKKAFFMQGCNELLVAHTYPYAGYEQFRTCCDFVNLLFVVDEVSDDQNGKDARATGQIYLNTMLDPDFDDGSTLCKITKDFRKRYMTSAGPNTTRRFLEHCCDYIECVSREAELRERDEVLDLVSFIDLRRENSAIRLCFGLFEYVLGLDLPQEVFDDPTFMEAYWAAADMVCWANDVYSYDMEQRKGLSGNNIVTVLIQENNFDLQAASDHVGLYFKVLMDRYLDARKRLPSWGPEIDAGVARYMDATAHWVRGNLDWSFETQRYFGSRYLEVKETGIVYLSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCQ9</accession>
    <name>A0AA38NCQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_20062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793364">
        <property type="protein sequence ID" value="KAJ3784771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCQ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF116">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="396" mass="43964" checksum="E0E894AD4146DAE6" modified="2024-01-24" version="1">MVFPYLCFLYSLVFTVSLYAGAALGSTILASESGQQSLAQSALAEILQRGAPILGFDTGCSALNATCDWMAKIPDETELVHMSIPGTHDSSTWNYTQATQDTLLGYTGPIVPAEYFQCQEHSFFQMLNGGIRVFDLRVALNPGNGTIGFYHSQALLAPNTRIEDVLFGFYYWLDLHPTEAVLLFINYESGTGTQDTLAFQKQLYDILSSGLANRYWVQINGSLGTLGEARGKLTLLQRFDYNLLPTAPEYSKRIGIHLDPEDWHDNDPNITLVYNTINETQQVAYIEDYYEMDGLPLSAGAAENIQWKYNATIAHLQDAININLHPDQLYITFASSEHDTDGETPRIMALGNGTDVPGVNQKILPWLQEQKGKRFGIVMLDFFDTVPGVVEAIIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND46</accession>
    <name>A0AA38ND46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transketolase, pyrimidine binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_427642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND46"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="570"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="927" mass="104195" checksum="1BF7A77491CFBC5A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDB3</accession>
    <name>A0AA38NDB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_290019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="118"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="486" mass="53171" checksum="6D61A5E193C021EC" modified="2024-01-24" version="1">MSLLNLARENLMNISSRRISRCFSRSATSRRPHFPCVEAHAVRESQLRQTTFGSIPSSVSSTEPSESGPEPPYARPNPKSYHVYHDPAPLELTYASPLPSFDVAYETWGTLSPEKDNAILLHTGLSASSHAASTALNPAPGWWEKFIGPGKALDTNQFFIICTNVVGGCYGSTGPSSIDPTTGTHYATNFPIVSIFDMVRAQFRLLDHLGIDTLYASVGCSLGGMQSLAAGWLHPERVGKIVSISGTARSSPSAVAMRYAQRSVLMADPNWNYGFYYDKLPPHTGMKLARQIATITYRSGPEWDLRFGRQMRPVLEQSPDKPRAPALCPDFLIETYLDHQGEQFCLKYDANSLIYISKAMDLFDLTASSLSANHLITSSLSASTPSLSFTPHQTSHSKSHPPPANPPPHLIDLAEGMQPLAKIPTLVLGVQSDILFTVEQQRETADALRMVGNEQVSYYELGGVWGHDTFLLDVLNVGGAIRGFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHJ2</accession>
    <name>A0AA38NHJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_391013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793640">
        <property type="protein sequence ID" value="KAJ3780857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3780857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="371" mass="40413" checksum="3AD5DEB6CE2F1A2E" modified="2024-01-24" version="1">MLQTGFINNAHTDLVTCAVYDYYGSKLATCGLDQKICVWLLEDSRWTLGDEWKAHDAPVVHLAWAHPEFGEVLASASVDRTVKIWEKDKGVWKEKAVLLDCRATVRQVEFSPSVFGLRLAVVSADGWLRVYDCLDQTRLDAWALADQVEFGMVKNPGLDELQQLQQVGTTSSASTSSTAGAAVQVQAGGSREADGGWSLSWCKDRYWGQLVACVLGSTGVVNIVQFSPSRPPQVVLKLEESPGVVISTVSWAPSCGRSYHLLATGGRDGHVRIWKVDGPMIEDEEDEDEDEGEKKKWSAQLVADFDDHANVGGMTGGVVGKVEWNVTGTILSSSGSDGRVRLWKATTTSAGRIWRIAGSVGVEQQKLKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHK5</accession>
    <name>A0AA38NHK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_124517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793614">
        <property type="protein sequence ID" value="KAJ3781022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="474" mass="52618" checksum="22068EAA66FC69DA" modified="2024-01-24" version="1">MTHDDSDVFSSSSSQFLSASSSQTGPRRSSSRQSLNSRRSATSLRPSSSLAQNMDQDSSNGRFSLAHELAAALMPEPSAGSRLLAEEFGIEYDEGAEGIDEEIQHPNDNNPQLLINSDEGPSFADELIHRDTLDTSFQDTPQHRAVRDEHEYDPVFGSPSATRQKKPKRPEQDAMEVLAQDLESTDKFLSHLRHLDTEPGSTTSTPQQLSLEKIAYDVIRRLDKTTRDREGQVRELLEYEREFRKIAGQVGGEDVLGQLEEITGMDELSEDVKTTSAPLVEPHLESVDEEPLHRSRVQEWDADPHQLNRDEEDEDDHDYDEELTPVKDTFPPPPPILGPPTPATTIPQLAHLRSFTRSLVSSLTTISEQAQVNGAATTEAGRKIRALKNKLGTWRTDWDSAERSRVKIERWEAGILDGADTPDGDVSPEYNISSPRSSGHKRVDGRLIVEEHLQAFELALADAGVKTKAIMASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHR9</accession>
    <name>A0AA38NHR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_437177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793537">
        <property type="protein sequence ID" value="KAJ3781637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHR9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="245"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="309"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="547" mass="61284" checksum="35D2C6BF0743E094" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIP0</accession>
    <name>A0AA38NIP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_166938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793903">
        <property type="protein sequence ID" value="KAJ3780123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIP0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041319465" evidence="2">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="19236" checksum="F7A2715C44591563" modified="2024-01-24" version="1">MSLFILRPAVFLLATVCAYPGRAHAEVASHNGMVFGPDSNGVCYEVSSQGPVTPCPTEVHPHLPKAAVAGIVIAVVFVIALLILLLLWRRRVRASTDDSASSLFDFVPAAKRLSLSTNANVSESQSRPGSPRFSVRTMIGSQLAMLTEKEVHESEDSYFHHGSYGPEVDLEGSVETLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ06</accession>
    <name>A0AA38NJ06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_380360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793679">
        <property type="protein sequence ID" value="KAJ3780648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ06"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="322"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="616" mass="67720" checksum="60673873D8B66911" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ15</accession>
    <name>A0AA38NJ15_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoglucanase V-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_380330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793674">
        <property type="protein sequence ID" value="KAJ3780678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041384430" evidence="1">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="2">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="190" mass="19137" checksum="A22DE7F582E1B969" modified="2024-01-24" version="1">MKSLIFLSIAAVVHGYVQLPSGTTSFTQYSGCGSPACGIAASGYTAAINQLAFGSAPGLGAGDACGRCFQLTGKADPYSPSFTGPFKSIVVKVTDMCPAAGNQQWCGQTSSNPVNSFGTEFHFDICEDTGGAGAFFPAGHTALTGTFTEVSCSEWSGSDGGALWNGACIKGESAALWPGSVGCGNQGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ20</accession>
    <name>A0AA38NJ20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA breaking-rejoining enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793921">
        <property type="protein sequence ID" value="KAJ3780094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17246" checksum="589B52D793C50F47" modified="2024-01-24" version="1">MPEQYSHLCVVRAFAHWISLAEIKEGYLFRKIRANDRIAEENEPMTSEQFLEMFRNNLIDVQVDHVPYGTHSFRRGGCQWLSVERCWPLRQICEWGGWSQEFTHLTIVKYLISWNDNPTVNRDDFFNMSRAPAVAYPTCNRTCHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJB4</accession>
    <name>A0AA38NJB4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_299934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793585">
        <property type="protein sequence ID" value="KAJ3781233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJB4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="59"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="501" mass="54368" checksum="22B06E12D3DEB772" modified="2024-01-24" version="1">MPDENELQEEDANQQATAISPEQDPTLLEKKWPTTDFGLIPIPERLQYHPNKPPFHFGLLLNASFGFASTFVVANLYYCQPLLIQLSQSFNVSYDEISKVPTLVQAGYAAGLLLISPLGDLVRRRQLILLIVLLSTTLSIPLAVTSSLTIFLTFSFLVGFVSVTPQVLLPLAADLAPAHKRASALSVVFAGLLFGVLIARVFAGIIAQFTSWRVVYFLAIGLQAVVLLGSWALLPDYPAKNQGTGMTYQKILWTMGKYAVTEPVLIQACLVNMGSSASFSAFWVTLTFLLGGDPYNYSTLVIGLFGLVGMFGVAMGPFVGKAIDALPAYHASLVACIALIIFQVVQVIGNGISIAAVIIAVLGLDIFRQMLQTSLASNIFSIAPEARARLNAVYILSLFIGQVTGTSAGTYVFIHYGWRACALMTLGFAIWQIVLLLARGPGLDRSDSVRGKRWIGWNGTGLERSRKTQKLSDVEEKDGRSGNQTPQVEGVDTKTHSNSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJX6</accession>
    <name>A0AA38NJX6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_409098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793495">
        <property type="protein sequence ID" value="KAJ3782163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJX6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="37670" checksum="B69DF70A7CC8E773" modified="2024-01-24" version="1">MSKEVKAWAATSPEKIEPLRITRRALDDEDVAIDIKFAGICHSDIHTVRSEWKKTEYPLVVGHEIAGTVSAVGKNVTKFNVGDRVGVGCMVNSCRKCENCKEGEEQYCLNMVETYNAKDPKDGTITQGGYSKYIVADQAFVLKIPESLPLDKAAPLLCAGITVFSPLNHWHAGPGKRVGIIGLGGLGHVAVKIAKALGSEVTVFSQTDSKKELALQFGADTYVTTSDPKAFDGLGRKFDIILNTVSAKVPLEKYLSSLRRDGSLIQVGVPPEPLQIPPFSLLPQRNGIHGTLIGGIAETQKMLDLCGEKQIFPEIEVVPASYINEAYDRVVKSQVKFRFVIDVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK61</accession>
    <name>A0AA38NK61_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carnitine/acyl carnitine carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_386372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK61"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="103"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="234"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="355" mass="38952" checksum="A0FA025B74ABEFE8" modified="2024-01-24" version="1">MTENQVELNPAVDFIAGTMGGAASLVVGFPFDTVKVRFQNPEFAQRYSSTMNAFTTIVREEKFVGLYKGITSPLAAVALMNGLVFASYRFLLKIQLDANNDIPTMSQIALAGAGCGAISSIITTPTELIKIRQQSLTTPTSAKQIAWDIFRRFGVRGLYRGGTSTILRDSGYGAYFWAYEATCRYLNSRVPSTTRSSEMSLVVHEFDHQPNQSSWTTMLTAGAVAGIGKLSYVESIGLYPVEHALAGWIFTFPFDVVKTRIQGTESSHTTQPLSTRLANTVSPPASYPVLSQMYSTKAMHSPVNPYRSTWPTIVNSYRSEGIRVFFRGLSPTLIRAIPVNMATFATFEAIVHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKB9</accession>
    <name>A0AA38NKB9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_298119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="MU793486">
        <property type="protein sequence ID" value="KAJ3782284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKB9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="330" mass="36940" checksum="6F1EE346B3781593" modified="2024-01-24" version="1">MFRIASSWAGKPSTGEDRATDDLPFPLESPIGRWREEMLDRDIGPKKKRRGKDWAQDAGEDFFFVQEMRNGSGVSFGLADGVGGWIENGVNPALFSQSLMYHAHRYSRNAWAGEPEIDPTLDYEEREQVEGWELTPHHCLDLALGGVLRERSVQAGSSTACLLTLNSSSGLLRSANLGDSGYSIIRSSNVIYKEKIQTHFFNCPKQLTKLPANPGRKFARVCIDSPKEANNHSMKLRDGDIVVVYTDGFSDNVFPSEMLSICSLVGRKDVTEDEQVQSMADNLVLYARQCMMDRRRVSPFEREAAREGMFFRGGKIDDVTVLVALVRETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKP7</accession>
    <name>A0AA38NKP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_296177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="106" mass="11743" checksum="0D37D30302C6EAB1" modified="2024-01-24" version="1">MSTASSSKHPESEQKSTKADEKKQETRPHLGVLEEDDEFEEFVAADWDDSQTDLAHLGGVAPGAAKSGGDKLWEDNWDDDDIEDEFSMQLRNELVKTGSGNDAMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL54</accession>
    <name>A0AA38NL54_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DOPA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_385132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="185" mass="21059" checksum="F4006D43E841B188" modified="2024-01-24" version="1">MDIDTRPANDLKEVLDNEVKEWHFHIYFAQKNADQHHAALELRDAVLRLRRDGAFVAVPLFRVNTEPIGPHLLGSYEIWVPAETFSSVFSYLCMNRGMLSILVHPLTREQRFDHESRSAWLGPTLPLDLSTLPLKSDEIPLQYASLRLGYSSETTPLSLDDRRRLGANVENLLKNEKGAARAPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL95</accession>
    <name>A0AA38NL95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_30471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793380">
        <property type="protein sequence ID" value="KAJ3784353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL95"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="40665" checksum="76AE86CC0646D95E" modified="2024-01-24" version="1">MNTRNSTVYSRIHDTENQIFILSSDDSELEDFEAKFTPKFIQEASESLEDARVARNNSKVVGRSSRGRLENILKIPLDVMLEIYGYLEPLDILRLSRTSKDLRAFLMIRSNAIVWRTARSNVPDLPPLPFDLSEPQYANLAFDSYCHICMRKPCEAIIWQCRVRCCNKCFSSTLYSRSNLHSVWKRSYASTFIVFKEIAQYIPYVNVVPWKGPWDGEDKVYFPPNVRSLRHEYRRVRKGEMELEDWVMQKKKAYEEIMKHTAACSDWQISSKNKRSEELKHARSRRKIAIYDKLRALGWGNEVDKLEAEGSSLLSAHRAVRQTKDLTDKAWNNMRPQLIKLLEDQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NND9</accession>
    <name>A0AA38NND9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endopeptidase S2P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_105732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NND9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="7">
        <location>
            <begin position="167"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="536" mass="59462" checksum="37186BF9187E53CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNK6</accession>
    <name>A0AA38NNK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_409044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="143"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="938" mass="100763" checksum="99F802EFBA568A71" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNP6</accession>
    <name>A0AA38NNP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793594">
        <property type="protein sequence ID" value="KAJ3781160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23954" checksum="D9F2E8FAD3A78106" modified="2024-01-24" version="1">MAAAPEYRRRVKELCTGRRVGLEGGLLEEVNSTYLLQPLQHTAVPKYLSADIFFNDFADAKEGDGFYVAKDSASLRGLNATIGERVVHCVTDSGCSIVAMSDATCNALGIAFDPTKRIGLQSANGRTDWSLGLAKDVPFRFGKVLAFLQAHIVDSPAYDVLIGRPFKVLTQANVQNFALGDQHMTLTNPNTHKTITFPTIPREPPRFRKEEGRERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPZ4</accession>
    <name>A0AA38NPZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_252030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="6018" checksum="65A9A4FF3A54A83D" modified="2024-01-24" version="1" fragment="single">PEMNIIENVWNFVETHICCRSPLPNSVDQLWVALQEEWSRIPVEYINKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQD2</accession>
    <name>A0AA38NQD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_372389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQD2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041332027" evidence="1">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="404" mass="39306" checksum="27D1259A38FA8387" modified="2024-01-24" version="1">MLFKSFVLALAYTAATNIAAPILRREVPQEHAHEDILILMRDAIATGSNSQNLGDPVFGLLGDAAAAGGLGDTTDPDCLQQNLADLAFTNAKAAGNVTLMTGALIYRALERNTGAVGLQSNACTSTTAANSEIAAISQHQDPASDGAAATNKAIVLALAQQIASIGGDPQDALKSGTFAPGTIGDPTAAGNTCDNIVDEGCINADNKLVEDATADEINAAVSGVAASSVAAATSAATDVATATASADSSAVTSVSSDGCTTEITVTETVTAAAADATSSAAVDVASTCAAPVTVTVTASASAATDAVVTASSSAATATTSAAAGQNLQTFTGDVGGQLPPAVTAGGRGFVVAGETGDSFLNVSAALQRSCSIQHNACADAANSGAAAGVTVGDCDTQNTQCTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQF9</accession>
    <name>A0AA38NQF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_305427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56402" checksum="6F3A0BA830B02950" modified="2024-01-24" version="1">MAKLPPANPAPPPPISVPPNPPNSSRSHPPPAQTQPPPMANGAHKGKRKNDTPVDPATMYESLKNRIAALEEEEELEEEEERRFAEEAHKSVRGLEETSIHAKYIDLFAEYKRLERDHAKEKQKLSKDKDAAKSQLTKANQTKTKMENLARELQKDNKRLREDGKRLAQCVEDAQDELHQMKADISKRAHKAQLLDNKYREKPNILVKVSCRYRAELFFNISRKTKLSKLFGAWTERMERAGHGVTGVKKVDGAAAAAGAKVESGTEGRIPPSFTMQFVFTHNGRSVDADMTPEEAGMENGDEILAVELMDLTESTGGDDLYEQFLEPQRQKLKKNWTDDPQAAQRSIEEIFDGVVRERLKEVLRQYELRERHFECVIRSKELEVLLSRARAAEQKQLANGDKTRAGKLEEEIQQLRKDLEDSQNGQTMLIDKLIQCCKEFRNEKPNAERTQRLFASLRDELEKRAPRLSSNANNSNSSIGDVTVNNGKKGPADGHVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQZ4</accession>
    <name>A0AA38NQZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein tsr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_42925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="86"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="918" mass="102438" checksum="C02D30289CCBEA34" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRG4</accession>
    <name>A0AA38NRG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_33099</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRG4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="14">
        <location>
            <begin position="396"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="757"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3789755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="888" mass="98665" checksum="FF16B26071354205" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSR2</accession>
    <name>A0AA38NSR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine protease inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_371268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSR2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23428">
        <property type="entry name" value="beta-trefoil_Ricin_SPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031755">
        <property type="entry name" value="Inhibitor_I66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16850">
        <property type="entry name" value="Inhibitor_I66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="145" mass="16267" checksum="49C0CAA1574B4CE0" modified="2024-01-24" version="1">MSLETGRYIIISGDYAVGRHFPEDRSLLPKGIFLIPKDWETNWVFEKSGNQQNEYTITSNGSPTAHIDGAVVALLTELFSVTKWIVEAVPQHGHNAYIITTPEHDQGWVSSEEVGQQILVKPLIATHSLPPQYLRNGVFQIIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSS0</accession>
    <name>A0AA38NSS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_303227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSS0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="152" mass="17283" checksum="9A91FE38B6E7FD02" modified="2024-01-24" version="1">MADVTDPAVAAEMKKKRSFRTFSYRGVELDKLLDMNNEDFVELVHARARRRFQRGLKRRPLGLIKKLRKAKKEAPPNEKPAVVKTHLRDMIVVPEMIGSVVGIYNGKVFNSVEIKPEMTGHYLGEFSVSYRPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSV8</accession>
    <name>A0AA38NSV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase catalytic core-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_282156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041345912" evidence="2">
        <location>
            <begin position="23"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="126"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="362" mass="38716" checksum="A4E141885FC6CA50" modified="2024-01-24" version="1">MTGKILNLLALASLAVMACSFGAEPVNALSDSHHARDGLRGHDALAKRKRSVNEKRCKVRSTPADSATASSTSSSSADYTPAPTTTSTWSDSSSSSTWSSTSSSAPAASSSASSSSSSSGSGKGCLAWPNGDQSYLGDYKTDKTSLIYTWGETAPSDAASLGFTFAPQLWGYTNADAFASTVVAGYAKYALFLNEPNESGQSNIDATTAAGLWKQYMEPLKALGYQVGSAATSSNPNGMTWTQDFFTACNGGCNPDFVAVHWYDISADAFMTYVEEWHTAFNLPIWVTEFAYQDFNGNDQGDLATIQSFMGEVTAWMDQQDYVQYYCWFGAMLDMQNVNPLNTLMNSDGSPSALGEQFLYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSW2</accession>
    <name>A0AA38NSW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_340333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSW2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19101">
        <property type="entry name" value="AKR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="38989" checksum="B5D1B91E4D930CDA" modified="2024-01-24" version="1">MSKKTHTSRFVSSDMESFQLGPSILPRMWSGLWQLSSNAWGTAPLLRIREAMTRYVHTGYTAFADHYGSAEIIFGQFRRSLPPDQPVFGATKWCVFTDIEPSQELVEAAVKERMERMHMDRIDLLQFHWQNYSQKGYLSTLKILQGLKTDGWISALGLCNFDSIRTDEICTQLGPGVISSNQVQFSLIDTRPLHGMADVCEKHGIKLLCYGTLCGGFLSEVWLNKPMPDRYSNHLTPSQRKYLDIIVGVWGGWQLFQELLLVLYDIGNGHGLSISNIATRWVLDHPFVGAVIIGTRLGISEHLDENLRVNGFRLTESDKAALDVVLNRSNGCRIITSIGDCGAEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSY8</accession>
    <name>A0AA38NSY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter NIPA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_340340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSY8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="595" mass="64757" checksum="AA391291055382E5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT15</accession>
    <name>A0AA38NT15_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_302960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="291" mass="32240" checksum="BFDB233755ECD34E" modified="2024-01-24" version="1">MVKHLPASVKQLLALRNPHPLPSPPLSKVHDVLMKTHLDARLRRAETGWLVLAACTLLTVNRPPCFGQLYRYVTRSDFNADSRNVSLEAAVNRAAIIREAALKSTIFVGVPRVILSLTALHEILDEDVKVSLRKESTQRLATSENIEATVARGKALWDSIYAPHADKLHEKLGSYHPDFIAFIIQAYGTVLSPLPGVTKTFLDASSIDDPNQGNLSRALGSVVGIACLRAEERVVPQLTSHVFGLLKARYVENQNDGDRWLSSDEGTEWVIRTVDEILDGVKDFDEHKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT92</accession>
    <name>A0AA38NT92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_430716</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT92"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="100"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3790727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="507" mass="56585" checksum="6A42111DAA42CB83" modified="2024-01-24" version="1">MPPSYESLPSNDSEQDITQPQARTPQKSGKRLNLLFIILGFLVSAFVFYKAGQWSVSPLPSATSGESLSVPTEDVKENESVSDENNGTTTSSIDQTMPGKYSVGYFVNWGIYGRKYPPSSIPVQDLTHILYAFANINPSSGEVSLSDLWADQDIHYPGDSWNDVGTNLYGNFKAIYLLKKANRHLKLLLSIGGWTYSPSFHPVVVSPSLRAKFVESAVKLLEDYGLDGLDVDYEYPQNDAQAQGYVDLSRELREALDRHATNKRADYRFLLTIAAPCGPDNYNKLRIREMDQYLDFWNMMAYDFAFKYVHLSAGSWDPVANHQANLHPSPTTALSVSQCISYYLSSGVAPSKLIIGMPLYGRSFLQTEGPGTPFNGIGQGSWEAGVYDYRALPLPGSHLMQDDKAKASWSYDYQKKEMISYDSENVGKWKGEWIKKMGLGGSMFWELSGDKGGPERQDMEGGHGKDVQPGQSLVKVVKEAMGGLEMGQQNWLKYDQSRFDNLRNGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTT5</accession>
    <name>A0AA38NTT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_338443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041320942" evidence="2">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="299" mass="28905" checksum="9D1DDD45AC012E45" modified="2024-01-24" version="1">MFSATFFAHCLLAFLFLDISNAFPLLNRQATATAQLSTPTTLTTVTSTMTPSGPLTQTCVITLTPITDSNGKPAVQEVKNCTVAANANNSTTATASSSSAASSSSASSSSAAAAASSSTTVASSTSAASSTTSAAAESSTSVSANAAISVNGITTMTSLAPSTETASASASASASSASDSAAASNASSSAATSAASSTSAAGSAGATSTSAATSSSATAAADNANPTSSGLATQQLAETTYVVPGKSLQVLPVGLGVFAGISALALIVVGLVTYERTKYRKAFRQRKLAEQGAAMGYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUE9</accession>
    <name>A0AA38NUE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rapamycin-insensitive companion of mTOR, N-term-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_280850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="164"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="615"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3791273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1281" mass="144536" checksum="879E5E5D5317ADC7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TXZ9</accession>
    <name>A0AA38TXZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="6">EF-Ts</shortName>
            <shortName evidence="6">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSF1</name>
        <name evidence="8" type="ORF">GGU10DRAFT_66479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TXZ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000001">
        <property type="entry name" value="Elongation factor Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="7">
        <location>
            <begin position="111"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="320" mass="35511" checksum="68C3AB38A3BBE613" modified="2024-01-24" version="1">MLRFTQAARCGRPLTRNRFYSSIPNKSRVQLVAELRKLSNAPIIKARQALDENNGDFDAAVQWLEEDMRKSGAAKAEKVKDRATSEGLISISVLEGGMGSRIRSGSGRVKASIIELNCESDFVSRTEEFARLANDISEIVAHSQTQQEDTSSPFTTLSVEDLLHLSHRSGTVGSLITDLIARIGENISLRRAMLLTSPTSSNTAYRVASYLHQGRVGALDLISLRPSQSSLFNDDSFIGDLEKLERALAKQTAGFMTLGISEKRNLEDELETVLYEQPFMMLGGENASIPVRKVLDQWQEKWGLEELAVSSFARWEVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYH1</accession>
    <name>A0AA38TYH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_384087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="455" mass="51660" checksum="99A3B52BF6E7E77C" modified="2024-01-24" version="1">MSTPTARRRTSLLNDLFDRKAPSINDLRVRECYICRQEERYDDAPEKRREWVHPCKCKLIAHQSCLMNSITRSTNQAKCPQCGYEYQIQRNLTFLTSSLLFRIGDTIFQAMGTSFLATSAVGLVTFTAVTVLAVGTGYGAIAVREYFGSGLSDLLLTDDPTNWHVGHHLLLCLTPLRLVSPFMNLGTFTPLFFIWPSIPPRSVREQLARESNGVDGAFPTNPSKKQPWPPGLKTFGFIVAGTSIVYNRALARFSEWVLDMKQPEPRGLFRGLTFRREFRRQEGPDGAEREAVLQLQREVPEEPDTPFANLNGVTQYPNISMILGLLKPFIASGMGHLLYVGAQHSSNLRFVLGIRDPLIAPLYTSPELVPELLFDNIWYWRYYTERVVEEMDPVWIRNSVGLGLFIIVKDCVHLFHLWLTKRELASRRLKNRDFSGVDLKGLDLIRPVSTSVSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYY7</accession>
    <name>A0AA38TYY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_342025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="527" mass="55656" checksum="65F084DB86A33C11" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0T0</accession>
    <name>A0AA38U0T0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_146900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0T0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="457" mass="49844" checksum="6F215E0789F7E146" modified="2024-01-24" version="1">MKLTVRGLAAALNSSGNFKKKAPEIAVDHLVIGAGVVGLAIAQRLCEKFPMKTTYLIERHARAGEETSSRNSEVIHSGIYYPADSLKTRLCLRGRELMYQRCRTLDIPHRKTGKLIVAKTNQRSYIENLHLKALKLQWPPHSAGDVTSSPVLPTELISGDEARAMEPNLSRDISAALWCPETGIVDSHSFMESLEKDILESETGDLAYATRVVRVDPYSTESSKVIPGGQGWVVQTVTGNEGQTESDAILARTVFNASGLSGPFILNSLLPPERRIPMYYARGSYASYKGPGISGISHLIYPCPDIGPNAHAFASLGTHLTLDLNGKIKFGPDIEFLSPPTSEDSEENMDYWTKHLSPDDSRLEQMHLAIKQYIPEVAVEGLQPDYVGIRPKLIPPGAGFQDFIFRTDYPCDFGGVGLVGESPMISLLGIESPGLTSSLAIAEYVVDDLLSSTKSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U183</accession>
    <name>A0AA38U183_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_339091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U183"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="363" mass="41611" checksum="11C102FCCBF84E89" modified="2024-01-24" version="1">MTASLAYYESFLLKNVSTISTLESSLRTLTWLLPGRFKDAELASEALSASLNMISMYHDTLLARIVQSDPRYRPLIPFSLHTRFTKAWADKNSRYKWAARLLETIRFTELFIEMGMRRKVSTKNRYRGIIILEIIKAILRLMLLRITRRPLLSPPIPERDIDPTTLPSSTETSPTLAPSSPPSSLPATPEHLKNNRVPLPQHSPLAVPPPPRSDVSIQEYLLPKALTTSAVKPPLSLVRSFSSPPEWLSEVLYILRPLVYATMLFSDRKSNRPLITILAMEFISRSLRRNVPPSASLERSEYARRDRDMLWYLFRGTIWQSYTRPKTAHLAESFSTTPILGLFATLIQDWIPLIDEYHYYTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U192</accession>
    <name>A0AA38U192_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps23 core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_103120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U192"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="8">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="410"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="487" mass="53410" checksum="0494CBCAF4039E4A" modified="2024-01-24" version="1">MSTQKWLRENCIKYEEKEKVYNEVNTALETFGLYGRSNGWLKVKSDVYTYDDGRTHLLLCLHGLLPISYRNSTYHIPFDMWIPFNYPRGPPIVYVVPAPGMMVKNSKFVELSGKCDVASYEGTKGSWLDKGEKRTGARTGLVGLVDALINWFGKDPPVYSKAVPNPQNPNPQPSPARPSLAPSLPNQAGPPHPSFSSHVGPPPPTYSPPLAPPRPPSIASTSWTPQPPPTFQALSAAPIPHQMPPASWAPSPPPPPRIQSAPIHQSIQHRPMQSIPMNSVPIQPASPPPPIPAPNLLDSDEPASAPDPGPSSAPPLPPNPVLLSLHSSVHAKLTSALQSFQTSLHHSLEHLRKIQEDLLRGEPAIQDEIARLEAVKAVSLNVGTRFRQTVEAAERNVQMLRNKGDVSVDELICGPTIVHNQLINLVAEDNAIEDTIYHLHRALNSGSIDLDRFLKTTRVLAEEQFMKRALIEKIQAGLPLGEHAMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1D2</accession>
    <name>A0AA38U1D2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_65974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1D2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3791125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="427" mass="47122" checksum="BE8F79A3E19275CA" modified="2024-01-24" version="1">MPAPKFRVAICGGGISGLCLAVALSRYPNIQVDVYEATDRFKEIGAGVMIWARTWKILEQLGLGPAFSRIAHAPPDGSIGTGFDFRRSDQPQEGFTYHSVKMSYGCIRFYRVDFLDAFVDALPSGVAHFGMRLVSYSQKAGANKILLEFSNGTTGTCDLLAGCDGIKSSTRAQLFKEAAERSGDVTLLKFIDPVWTGTIAYRGLIPVERLPPSHRTIADPTMYCGKSKHVVSYSISRGDVVNVVTFASEPESEGSSYSEDTGGTHCPQKELLDCYAGWEPDVEQLLSQIEKPTKWAIHHLRPLPFFVDGKVALLGDACHAMAPHEGAGAGQAIEDAFILAALLEHATHETIPFALEAYQHVRLPFANHVLKGSYDSGLMYEFNSEYGEDYKNLGPVIEKQWDWVEEPDPEKERLRALQYFKELASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1V7</accession>
    <name>A0AA38U1V7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_340407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1V7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13942" checksum="5F706FB88F6D2A7B" modified="2024-01-24" version="1">MSSSSATRLRREEDVEKAYAIQVQAGLEGAARFTAVGLGLSIIAHHTWPAFRHQGRPFKAFLLSMFCVAGVVFGAERALIAHEAQRRLEENHLRRIARLELTKHGIVPTETEIAKWRLSNEQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K816</accession>
    <name>A0AA38K816_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_278142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793601">
        <property type="protein sequence ID" value="KAJ3781119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K816"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052922">
        <property type="entry name" value="Cytidylate_Kinase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37816:SF1">
        <property type="entry name" value="TOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37816">
        <property type="entry name" value="YALI0E33011P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23960" checksum="403E38038F564526" modified="2024-01-24" version="1">MAASQPNVLPPLIGDSQGRYKIRVLGNSGAGKSTVSHQLASILDIPLLSLDELYWQPGWKPMPNNEFRDKIMSFMEKNASRGWVVDGDYVRMGGAVVHEHATDVIWLDPPLLLYFPRLVYRTFLRLIGLESSCSVGCSESIREVFFSKSSILWWCLSQHRVVIDRNSAQMKIWGLEVGSRPPKERKMRRLGGWGSEVTDWLQSVWKMVKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8B5</accession>
    <name>A0AA38K8B5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_366033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793535">
        <property type="protein sequence ID" value="KAJ3781659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8B5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF65">
        <property type="entry name" value="ANTHOCYANIDIN 3-O-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46830" checksum="1C8E87B888A48B94" modified="2024-01-24" version="1">MSSVKNILFHALPAWGHNKPMAALAVIITRARPDIVITVITTGIIYPKFNNELKSKLSVEEYDLLSPRINIIDVSGPNVNPFEPLKEFAPAYTAIWNSESILCKSSGKTFTALPPPTVVILDPFTPYAYESIYAISQKKVPIISWVSGPSGPLLRIFGPASLGGDADPSLETEAGLKLARAQLLEPPSEAAKSMVGSNVTSDTILEKSNVPGMPPMYAHECKPQISLLPEGPFARFGQIYTRAGDGVIVVSNSVYEQESINATKEWFSGIGKPFYALAPLTLPNSKGQEDTEHREVTHFLDSVNERFGPRSLIYISFGTFFWPPEQEKLVAVIETLLENQIPFIFSHSSPMANNLSTEFLASINNSGFAMEMVWSPQETILQHKVTGWFITHGGWNSIQEAESFGLWVVISQSMPLSSVSLTKPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8C2</accession>
    <name>A0AA38K8C2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_390439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793533">
        <property type="protein sequence ID" value="KAJ3781689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8C2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09245">
        <property type="entry name" value="BRO1_UmRIM23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="449" mass="49505" checksum="E801059CE21914A1" modified="2024-01-24" version="1">MTTFLYDLSTTGAISFSDFINDPDNSFTRRLSEITQLRSRLRGFLKESKRTDGEKDYLTIIKIIDDYLPHLQGVINCVNDHELELKFEPVFSWRTTLSANFLNNSPRMTLQSLNAEHASSLLTYAFAHSNLARAIVASLGPYEHDRAISQAEREAKEEQLKHATSHLSRASGIFTYLSETVLSELQQSASVTKFKLPPDLLPEVNTALSRMTLADAQTLAIRKLLSKSFYDCNIAPGPPLPKSHPAPGLIAKLHLECVSLYSTARTLAKTPSASSKSSEDVSPELRHYLADETSLNSALAKKWLGIDAGENGGQKRGGEAVGFLIWAKKELQDIKDGGKGAALAKGEKEKRDRNLRKEKVAIELETIDSWLKHYKKVNDTIHFQPVPSQAELQSRIPTGVSAVFSIPYVPQKPAFGPGSDARSQKEQATLDQGDSMSGSSTYAGAGEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8I6</accession>
    <name>A0AA38K8I6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adipose-regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_364734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793502">
        <property type="protein sequence ID" value="KAJ3782064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8I6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3782064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42674" checksum="37BE55935A61EDEA" modified="2024-01-24" version="1">MRSLKISATGTDTDRLTLGVSNLQVSLMDAETAEKERISYGFWSFLLQAPFNFVSQHLRRYTPNLVSLSVFLLFIPLICTLSLSAGVIVWRNIAVGWQIPLYLQYGDGVQPFAHAVLVDLTARQPYNIVLQLVVPSTDSNFALGNFMNSLTLSTINHKTLAAVRRPAIAIPPKSSYFSSKTHLVTIEIPMLDSFVPETAQVAVDVKIGRQDVWKGIGNGEGRELSVYSASLKGILVHKGIRGLVTRFPTIFSIICSAIFFAILFSILSACLLPSVLQSASSRDTNESPKPPEDSEQKPSTLLADDHQYPEDSSDTETDASELQGEKEVKPSKSARRRKRRSAKNKIVSEGSSVKSESDPVIVSSDLLGRSTNPLRRRRSDKPSDMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAZ3</accession>
    <name>A0AA38KAZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_417271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAZ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041463132" description="agmatinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="409" mass="44246" checksum="C45055F10FD6982B" modified="2024-01-24" version="1">MKLSIPSVLLSVIAVFASERQHGHDHDHGEQMPLDYVKFPYEQPLYRTSTGEVTADAIFSGITTFAKLPWVQCLTSQRDVPVDIAFLGAPFDTGTSYRPGARFGPSGIRAGSRRLNLYGGYNVPLEANPFKSGYRIVDCGDIPVSPYDSAYAVKQIEAGHKSILQRAAFMPAANDSKTGEPLDAIALDGKSHPRIITLGGDHTITLPLLRSINSVYGPISVIHFDSHLDTWKPRVFGGAPSDTAAVNHGTYFWHASQEGLIRNGSSIASHGAIRTTLSGLEDYEVDDEVGFQRIEAREIDTLGVDGIVKKIHETVGNRPVYLSIDIDSIDPAFAPATGTPETGGWTTRELRAILRGLDGLQIVSADLVEVAPAYDTNAELTTMAAADVLFEVLTVMTKNPLGKVKAKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB11</accession>
    <name>A0AA38KB11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794907">
        <property type="protein sequence ID" value="KAJ3779443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="156" mass="18101" checksum="C20830FB58BBCF22" modified="2024-01-24" version="1">MSSPQKLTSSQIAAQLLAAQEEERMEAERAKKVAKEKARREAEEQRKRQEKEIAEKKRRIKEAKRVKAAKKKLEEAERKRQEELAEARRGKAREVVPKKRVLEDILDPSDPPYQEESEDNDEDRDEEPKAPKKKKRKGNNTQLQVLHPLGPPAYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBJ2</accession>
    <name>A0AA38KBJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_252760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793836">
        <property type="protein sequence ID" value="KAJ3780238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="100" mass="11307" checksum="2E27031C93557EFA" modified="2024-01-24" version="1" fragment="single">KCQNCQRQGHLAEECYRKGGGKEGQYPTWWKGKKDVSTGNSVANNMTTTMATINPMPEVGELTQYYGLATASNIEDRDEIFADTGASDHFFRKREDFLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBL0</accession>
    <name>A0AA38KBL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_380815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793793">
        <property type="protein sequence ID" value="KAJ3780313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBL0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25710" checksum="4978B79F57CAD09C" modified="2024-01-24" version="1">MNPDQGILVGSKTQLYDYDWKAFVDFTPISQEFPPARQQAIFHSRSILIRNAPHNIYNFNSLSDMEVLGEETLYNFALLKNRNSPSFHPNDSHFKATLEELIKSAELRQAIINCLDISIPSTKAPGCQGLATQAEAEGYIRERVDQEGMYWAIAGQKGAYSLLHMDANGLCTVVEPMTGQKYWVIARPKDDVIMSSIDLMDILNVELEDIFLFWNFYAVILQPGDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBS5</accession>
    <name>A0AA38KBS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_263419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBS5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="38767" checksum="0A12FC0B585C56AE" modified="2024-01-24" version="1" fragment="single">ESEVYSQLLWLRKRGYPFWTPEPTQPIPEEYTRQGIRIGDVGILTTSGGFDYLFNTCLPRDDPANSAGVPEGFEPLIVDQGHIQQERRRFPPGSYVYVSNSWPDVQMTRLRSQANIPGVPDEFGAGLTFSPRASTGALLILPEGASSTDHKSLDEFRDYGIIWARKWFQFANSSPYSRGTKNLYLVTGCDKTRAWGVSSFFNGPVGSVTMSFVPTAGELPGYRFENRHCAEVQSGSDELGNQSSCVFVRGFKIAIRQQPFVPKKRTVKVTHSSELNMDVNDFFSRQNNVRDPSSWDRMLGHLGRATSSEIVDRDADRNSPPFRAQVFTYLYHISKPLNDVGVSSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCS9</accession>
    <name>A0AA38KCS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794365">
        <property type="protein sequence ID" value="KAJ3779696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCS9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="258" mass="29314" checksum="C13C177662B9D885" modified="2024-01-24" version="1">MTASRTDAYRKYIDSWVNDLRTLYPHTRQGVPRPNIHAAGHVYDFLLLFGPVVSWWCFPFERLIGALQKINTSDHIGGEMESTIVRTVARTANLRRWLRRRDCPEAIRQLKILFDKCFVPANAPSSSNEFVEQKGPHRAYVKHNGVNLSPSDTHAGNANIIYRPSASEPPVAGQVQRIENIHTPDGKNTDVRLHVQRYNPISKALYDPFLRYPHLLAKSYSTSLNAQVDVIDLDDVIAHAARYDYSHGRSVLVNMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD37</accession>
    <name>A0AA38KD37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_389506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793447">
        <property type="protein sequence ID" value="KAJ3782893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD37"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="343" mass="37727" checksum="943FF4B2C2A20ACE" modified="2024-01-24" version="1">MDSEPNNDAHDFISSNASAAGLDALQTVDLDRLDLDPGTRTTLRRLQELGFDRTDLSSHLLKNPKRLAAVLVLLYPSSSPSHSSDSQESLTTPASSTLRVLLTTRSKSLRSHPGQTALPGGRVDEEDREPKILWGAFREAYEEVGLPFPSALLSAASNTMQDFASIPHIPNIHILCTLSPHLSQWGLIVVPVIAYLSSPISLVSTSTHEHNNLPSLTLRANPTEVDRIFTHPLEGMLDPSLASGRGDLADLAEKGSEDWPYEDELYNSTDRAYPQLGNSIYRMHRFRSVASPIKGLTAEILLRIARIAYARDPVEPIEQYAPGQVRGFEEICRALDEYGGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDD0</accession>
    <name>A0AA38KDD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_404872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793423">
        <property type="protein sequence ID" value="KAJ3783358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="78"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="1243"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1471"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1511"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1521" mass="169543" checksum="1461E3E188277F4C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDD7</accession>
    <name>A0AA38KDD7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_139173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793689">
        <property type="protein sequence ID" value="KAJ3780611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="323" mass="36063" checksum="723722D59A143976" modified="2024-01-24" version="1">MSSDVSAAQDKRNLHYIIRSGLAGGVAGCLAKTVVAPLDRVKILFQASNPDFQKYAGTWSGAFRAGSEIYQTSGARGLFQGHSVTLLRIFPYAAIKYMAYDQVHHYLMPTRHKETNLRRFLAGSLSGMISVFFTYPLEVFRVRLAFHTKYTGKANNSLLGSFKQIYHEQATDISRPTVNASHYFDRYPLLKFYRGFSATLIGMIPYAGVSFLSWGYLRARFIPPPNDAKIQSTPVADLAIGAVSGGIAQTASYPFEVIRRRMQVGGITQPDRWLRWGETVRAIWVPSGWRGFYVGLSIGYLKVIPMTAVSFTVWQGGKRFLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDI1</accession>
    <name>A0AA38KDI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_128592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793635">
        <property type="protein sequence ID" value="KAJ3780881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="294" mass="34728" checksum="977D827FFAEE0942" modified="2024-01-24" version="1">MLYVSLVIPNRLHWLRDKLENIVSKVWDVIFGRFIFVKDMGRRDATVEVATMKFIRQHTSIPVPKVLGVLRYRGKQHIFMTRLAGKEIDDRQWKVYSQHTKDAILSQLRSFITQLRQIGPPPQTPPFICNILGGPIMDHRLCVDHPYGPYRDEEQMNLQIRQGLTVDRFAEIGKFPKEVTELIRQSHDLRHPIVFTHNDIAMRNIMIDGDRVTGLIDWECAGWLPAHWEYVKANWTEFYVEEWVRDLRTFIPPFDMENEADRAIGWSRSWMASLDIPFDPSWDLSWESWKAQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDN2</accession>
    <name>A0AA38KDN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_336575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793591">
        <property type="protein sequence ID" value="KAJ3781181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDN2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47165" checksum="AEED9FE47281906D" modified="2024-01-24" version="1">MTAPQITVNPNYPRHKVKHVNLMVEGYLLGKRNLRRVIRGLLASGTSGIASAFSAAARNHLYESGALIPPNLDSLFDRDVGNGEITPTRTLREVIARARTVYGALPPYLVQGNFISYAWAPASIVALLGTFALVANCLFSPLIQGERFRKRDIFGITIAIIGAVTVVLSSNASGRLNPAALVRAISQTPFIVYTCIYVGAMILASLSQSSYGQRCRSNSLFESGAHEIRQQGGTFRRSLVPLLVLYGDFKKASFHQIVTFLYGCAATFAGVFIIAWSSESNESEFEHRGTEQSNHGNFDGAASIRAEQVASNLSIGSLGRRRATLVLPDGISDLPSLHHKHSGISVMGLSPAQPLLLVHTPPREHPMRDFERDGSTPSSYQRQRAISWFGDDSSPRGRMYEGGRRTRDSSLAARLRSSAGASSVSQALSHLPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEE6</accession>
    <name>A0AA38KEE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_398929</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="MU793349">
        <property type="protein sequence ID" value="KAJ3785233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="933"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3785233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109693" checksum="6D1CA60C026D0B37" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFC9</accession>
    <name>A0AA38KFC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_359507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFC9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="72"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="641" mass="68455" checksum="579DE10C59DD81CA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG83</accession>
    <name>A0AA38KG83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_347775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="33230" checksum="2E05B887A0264D45" modified="2024-01-24" version="1">MLTDSLNAILATNLRDDRSFYGYVPTEWICILFVVLYALSTVTHLGQACWYRAWWMIPTACFCGILEILGWAARLWSSHSPGLAQPYEMQITCTILGPTPLIAATFVILGRIIDLLGTSYSRLSPKMYTIFFCSADVISLIVQAVGGAQAATAVARDTSPVSGGHIMLGGIVFQLTIISVYVLCGAEFFYRYLKDQPLRDPGTLHEGNIRRGALTKKLKVQAGALMFMTTCLWIRSVYRTIELADGWRGRIITTQVYFNVLDGAMVTLSIFALNFAHPGFLVGEPGKAASKFVDEEKTSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGL8</accession>
    <name>A0AA38KGL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_352685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGL8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16270">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041396297" description="Anaphase-promoting complex subunit 5" evidence="7">
        <location>
            <begin position="31"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="8">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="673" mass="76499" checksum="C817C3363EB729AB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KK76</accession>
    <name>A0AA38KK76_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794241">
        <property type="protein sequence ID" value="KAJ3779774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KK76"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="122" mass="13628" checksum="890DE009092D888A" modified="2024-01-24" version="1">MCLDLLPSAVHEHKPTMGLIKTKISKELMNNRVVAKALLTNGGKVGSGFWDNVDTALQVVRETHKEDSIKITQVFTRILTEDQATYTDFGSDENLDRLAEVLKAMSRSKNGRSYITTTLVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKQ5</accession>
    <name>A0AA38KKQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_381658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794143">
        <property type="protein sequence ID" value="KAJ3779850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKQ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="108" mass="11604" checksum="69647FC49AABD3A9" modified="2024-01-24" version="1">MAILTQPVKVTGLLSVIMAKFFTPRNPSAIFVSGPSLPNLLMSRLMLNLRTFPTPGTGDTLTQRANLSSLHFASNQMLGNIGAPLDGGSFSEEEEELNGVEIELENIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKX6</accession>
    <name>A0AA38KKX6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_368297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793630">
        <property type="protein sequence ID" value="KAJ3780914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKX6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041392465" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="20222" checksum="C5041CA6B09AAED8" modified="2024-01-24" version="1">MRLDSVTVFLLSLCFFSNTTTAIPFPSENTSTPMYSRASGPEVHVKFTQSGDKVQQDVSAWMNEGLKYAFNKVPHLGSSDSTFTLDPPIPKRSGPKLTFEFSNDSPLCVPKCTGSLLANPFDLVKSHMIVYDKDKKQIIEIGPTTNQKAHFYHENNEIVVVEGPYSSVDHAAAELGAFGFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM21</accession>
    <name>A0AA38KM21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_275419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793472">
        <property type="protein sequence ID" value="KAJ3782504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM21"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43702" checksum="98B81FC157164E2F" modified="2024-01-24" version="1" fragment="single">KRENLIEWILWALFSSGPHKAKDSWKDEIDGYVRQIEEITKVKFENGQDEGMKALRLTLDEVKMVHRPLVWYIIVALVDLITSIKLYTMNFYQYSPPTHSQFFPPRLFSIFSTPSPSVTDHFSYWYRPHKSSNRDPIAFIHGIGIGLHPYIPFLQDLIQLDSDQGILLIELLPVSMHICSSTSIPPRREMLDAIYTTMHSLGISRAVLASHSYGTIIAAHVIHDSQETNHHKSNSEHNQTSSEFSSPQIFFTSHLPIDPIPMLLHLPAVAFNFLYRVPREANEWQLWYFASRDPDVAYTLGRCFFWAEGVLWREDLGVEVDVEPHESRLTDQTSKVQFAIILSGKDQIVPAPLVRKYLTGEDEVKERWLSGSNVNSHFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM63</accession>
    <name>A0AA38KM63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Splicing arginine serine-rich 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793459">
        <property type="protein sequence ID" value="KAJ3782699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM63"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="35091" checksum="EC6F37DBB6EC44CA" modified="2024-01-24" version="1">MPSRSQSRERSEEDIRLPHDAKPITEADYFQKSDEFRVWLKNEKGKYFDELSGEKARSYFRKFVKYWNRGKLSSSWLRLLFRELKPTLILESLYAGIDSSTIPSRAQTGYKWSFASKTSRADDEALQRARATVSAATLNRDFDERLEGSSKSDRGSGRVQGPTLPSSSDIQLAREYAAETREEEHRLKRKRERKEDKERVEDMVGPKEVGREGMLEKKRAKRENDRTFRDKGDEGLEVDESVLMGGGDSFKQQIARRDAARHRHQQKTEDKANSMRERASVFKEKEDATMAMFQKLAKERFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN16</accession>
    <name>A0AA38KN16_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_335119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793444">
        <property type="protein sequence ID" value="KAJ3782955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN16"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="369" mass="41324" checksum="CCD0FDEF77659276" modified="2024-01-24" version="1">MDKGHKNQDPGPEVVSGFNSINHASRAASFVRIVLSPSSTVAPFLQELSLIVRPLSLYSSPTTQSADAWLDELLALLPATRTTSFPSQALSSPPPRTSSPLQSPFHLRTLRIFRHGTDLSPFSRLALHQNFANTVTTLALFETTLQKRSLKRDMEWVCGFEKLEDLLFYGHHRGEQWIRRDGAAGDTDNGDPPWGRTHPELTFDLNDDLDAVDAQGRTTIRLPQSVRRLRLDLPGSALEAVMRWLLAHAFGYGLSKANSSNEVQKNLGVGNFQAKENEGIPCVSTLHIFRVMQNEAPALRAYLRACKDTLEDLMMFLYQNSTNRGELAVKFPQSDSLIWTWRRLRLVHSHRSAIALLGVQRVQTNEGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPI0</accession>
    <name>A0AA38KPI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_319554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793516">
        <property type="protein sequence ID" value="KAJ3781881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPI0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="291"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="422" mass="46252" checksum="6C07ADDC2C337739" modified="2024-01-24" version="1">MTLPSSTQVLIVGAGPNGLACAITLLTLGIKPIVVDDRSERPYGAKGCLIHARTLEVLKTVGLSDSLKDIGIQSKGIIFYGKANPLFKVDIAALSSLTEFPYILLTPQSEAELIFEKFLVDRGVEVIKNTKVIGFVENPAEGLHVSFEDGSSIIASYVVGADGARSTVRSLAGISFKDPFTNLMYDENPSSASFMLFTLADVFLNLDPSIHIPRETISWHLNGRIMFCPLELPEKLRHNCKENTSFWRIAIAIPPGSHTIPPRHPDQTYLQNEINERNPWKEPIHLDHLYTAATYRVRSAVAETFFKTVGNGKVLLVGDSAHVHSPSGGQGMNLGICDAVTLGRAIAEHIESGNDAVLSDYSSKRKATAIQVIQATKHMTAIINIPNGWRRGIANILMYVASWLTPIRRKVAQRLAGLTYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ35</accession>
    <name>A0AA38KQ35_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_74424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793459">
        <property type="protein sequence ID" value="KAJ3782706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ35"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60214" checksum="C8FE981F5BFCBBCD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ75</accession>
    <name>A0AA38KQ75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_7834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
    <dbReference type="EMBL" id="MU793349">
        <property type="protein sequence ID" value="KAJ3785220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ75"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="13">
        <location>
            <begin position="187"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3785220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="473" mass="53450" checksum="F590934BC462C058" modified="2024-01-24" version="1">MPFDPVRDAVLNSPATEGLPTSPSVARRATHLSVLLNADSEPLPRTSSSLSQIIHLEPTDKLSSVKPLKKAQETTLSPSDSRPSSSSYFQPASTFPPVMRPPPLLYNPTQRVTPPDSILTPMSKAEMEMYKSYVGKGTARLVKRKRPRDDSDTGDEPPVKKSVGNGGVVVEHYNARPEVGVIQRLDSPIIGLKNFNNWVKSVLISKFAHPALVTSSVRTQRNKGKVLDLGCGKGGDITKWSKARISDYVGADIAAVSVEQAKERWEFNRNANRIQASFATYDFCSQNLEDVFAPEILEKPFDVVSSQFCIHYAFEKEETVRRLLRNVSHWLRPGGTFIGTIPNAEQLLEHLRELPPENQDLSFGNAVYKVRFESREHSGMFGRKYWFFLQDAVEDVPEYLVYWDNFVSMAAEYNLQPLYKEEFHNVFSEHQDHPEFGPLMVRMRVMDANGESSMDEDQWEAANIYIAFAFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQB1</accession>
    <name>A0AA38KQB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_387547</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQB1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="13"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="360"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3785340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="473" mass="51668" checksum="669536D12CA60FF4" modified="2024-01-24" version="1">MPPIFNRPTTDKYDLVIIGGGSGGSGFSRRAASYGKKVAVVEMTPHLGGTCVNVGCVPKKIMWHAADLRERLMYHTSGYKMQGIPEAPKFDWASFKPQRDAYIRKLNGIYHSNFDKEGVEFHQGYGRLKSPKAVEVTLADGQTYTLESDNICIATGGHPTIPSEQDIPGASLGITSDGFFELEEQPKRVAVVGAGYIAVELAGVFNSLGSETHLIIRGETVLRTFDPTLQQVLTPWMEHTGIKIQKSSKVVRVEGEKGKTLTVTLDSGKKIEVDCVLWAIGRHALTQDMGLEEHGVKLDEKGNVVVDEYQNSSIKGITAIGDVQGKALLTPVAIAAGRRLANRLFGPEKFKNDKLSYENIPTVVFTHPTIGTVGLTEPDARKKYGDDQVKIYKSSFRSLYFSMVDEEHKEPSTYKVICVGPEEKVVGIHIIGMGSDEAMQGFGVAVKMGANKQDLDDTVAIHPTSAEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRG7</accession>
    <name>A0AA38KRG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_165444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="70309" checksum="8494CAF2F92A76F0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTA1</accession>
    <name>A0AA38KTA1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_289687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTA1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="590" mass="64736" checksum="53A71149BE1D6879" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTZ0</accession>
    <name>A0AA38KTZ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_264239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="313" mass="35554" checksum="577B05FDCB848590" modified="2024-01-24" version="1">MSQFAEVSFIGDDDSEYFRRLFDRTFNNLNPRYLLPADEDEVKRSELHHRMMQFVFQGNNYVGPVKEALQFGQHRRVLDLGTGSGIWAINMADEFPRAEVIGIDLAPLQPRSVPPNCTFELCDIESGIPYPDGYFDFIHARSIHTGIRDYPQFLREITRLLRPGGLVLLIEPDLTPIVDGKPVALAPAGLGGGDWSTFWETYRNCLRRQDIDTTVPQRLTDMLTTTGAFENIVKRDGNIPVGFWPKDPLSLSVGQLQWLDYDLFLPALRPMFLFHGLTENQVRSLITGAQRDLYHPVAELSTHVNIVHASKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU54</accession>
    <name>A0AA38KU54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_277273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793542">
        <property type="protein sequence ID" value="KAJ3781602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="259" mass="29000" checksum="64D0E024890FF35A" modified="2024-01-24" version="1">MPDMVTLSYPSPSSKPQQRQFNPYSENGGTILAISGADFSVIAGDTRQSEGYSIQTRYAPKVFRLTDNAVLAVNGFAADGNMFVKQVRQRLEWYRHAHAKDMPLRAIARLIQTMLYARRFFPYYVYNILGGIEEDGSGAVYSFDPVGSYERESCRAAGAAQSLVQPFLDNQIYFKNQVALPGHPHPQHLPLTTVIQLVIDSFTSATERHIEVGDGLEMFIVLAKGSPLYGLENIDGVQEMTVTNEGERIFVVRRNLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU75</accession>
    <name>A0AA38KU75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_98180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="MU793532">
        <property type="protein sequence ID" value="KAJ3781692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU75"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00525">
        <property type="entry name" value="AE_Prim_S_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3781692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="48540" checksum="EF9973A62541E399" modified="2024-01-24" version="1">MAPSSNLDIDPTSEEVLLTFYRRLYPFKQLFRWLNRGPERTEKESRLFPYREFAFTLRNDAYLRYNSYPNDIEMKKHVCLLTPSRFEIGPVYSAQPRDKKTVRPTHFKAERREVVFDIDMTDYDPIRTCCSDADICKRCWGFIAVAVEVLDTAIRDQFGYTQLLWVYSGRRGIHLWISDKEAFELTDDQRKAMVEYLTVIRHGKEPGKRVNVRFGMKDLPPTLKDACQTINQTFDELILQDQDCFGTQEGYETLLSLVPDVKMASRLRERWSQKPDSPSYVKWDEMKAEVKDLKDKHARQNMRNAMEDILLQYAYPRLDAEVSKHRNHLLKAPFCIHPKTGRICVPVDPDRIREFDPAKVPTVSQLLAELDAAGPSNGEHRDDWQKTSLKPYIDMFEQYANSVQEKQAKMDLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVH5</accession>
    <name>A0AA38KVH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZIP-like iron-zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_271981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVH5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3784167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="340" mass="36281" checksum="1B9310D95A8DA4C8" modified="2024-01-24" version="1">MKRDVIDCSGDSQGDALLGLRIASIFIIYVGSSCGALFPVLARRSKFINVPKSLFDFAKFFGSGVIIATAFIHLLAPALDELGSPCLSEAWSEYPYALALCLLSIFSIFILELVAFRWGTALLAKIGVHHDAHGHDTGSHAAHGPEGNISNTSKDVEASPSDMISSKSDEHQHRVLDSAISQVIGVAILEFGVVLHSVLIGLTLAVNEGFKVLFVVLVFHQTFEGLGIGSRLAYMKLPSKYNFVPIIGAVIYGFTTPIGIAVGLGLRTTYNPNSATASIVSGVLDSLSSGILIYTGLVELLAHEFLFNKEMMESSNARLTYALGSMLLGCGVMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVV7</accession>
    <name>A0AA38KVV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_399990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793362">
        <property type="protein sequence ID" value="KAJ3784842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVV7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="34971" checksum="7EBA7AA0C7839A9D" modified="2024-01-24" version="1">MTATISKHIVLHAHAIAWGHNKPLASLAVLIVESFPEVVVTFLTSASMLPRIMSELERLDPSHSQVIGSRLHVLDISGAILDPRLPLAGFALAYAASSVCRRGKLSLVVPPVKQSPTYLLPLWESSMQPFTAYAIEAIRVIAKDTPILAWWTAPAGALLRLLGPSSIGGMADTSIETLDGRAAMKAKIFARKEFETPLSDLTPIIERIGCIYIRETDGLIYTSSPAFEPRAIAAVHKWYASIGKEWFSLGSLTKNIETSSTKNRVTANSDTNKQVIEFLNRMQENFGGKSLIYVSEILEYELVMNLDLVWDNFLSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVZ0</accession>
    <name>A0AA38KVZ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794802">
        <property type="protein sequence ID" value="KAJ3779483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="117" mass="12995" checksum="4CE68806E7F7E8B5" modified="2024-01-24" version="1">MSTDLSWSMDKPFTGSYSSDILLLSAWLHGQQPAESSAQPRPRNHSNLTFLNHLSTLLTTGNKRSPSADNVLAVSGYMDAKLIHCLVFSKNAGPMYNILRGKMLAVDRPWIHRQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW70</accession>
    <name>A0AA38KW70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_387452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW70"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="58880" checksum="30C049C469A6C55A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWL9</accession>
    <name>A0AA38KWL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_420287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWL9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="261" mass="29286" checksum="2FBEF1263B946566" modified="2024-01-24" version="1">MDQKGEFFCRNCGRKFPLFQNCSHAQCFQCEKVEAAGDDHITIEEIERIPMCTGCGLLLRRLKGDTCDICSEILSGRILHGQNSQCGVTNKSGVKEPQGLAKMRMSKQRQPATATMSDPIEIDSDNSDSATLTRMEHDDSNNALPLLCSQIEKKRKVASQIRLTHKDPSTSSDLPVATKQYLKKKVVQQGISVKVSNIAFHIHVAIQHKDGQTKGTHVPFQTKTFQTDDEMSEVFEGIVNIFNDSKGKWLQNYCNQRCCQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXB0</accession>
    <name>A0AA38KXB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Costars domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_97540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the costars family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793530">
        <property type="protein sequence ID" value="KAJ3781718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXB0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032970">
        <property type="term" value="P:regulation of actin filament-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044302">
        <property type="entry name" value="Costars"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334:SF1">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Costars" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="65" mass="7086" checksum="FB36DA733FBD10D4" modified="2024-01-24" version="1">MNTSEEITILKDAIIEYGSVNSEGKHSVAYGTLFDKTANTLEALNGTLRAAKRQKKVFLVLVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY24</accession>
    <name>A0AA38KY24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793449">
        <property type="protein sequence ID" value="KAJ3782858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041297913" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="269" mass="30772" checksum="94C09F8A813D0CC7" modified="2024-01-24" version="1">MSFQTRMLFAIVHVVIVKALSLVPGSNQATLLVGVQDWELEYSPAPVITGFEAFTQYTRCGDIGDSCWFTPCCDWALCFSTRCHSKVPWNKKQQPPPYYKDTKTRLAKGDNLTIEVHRSYHGKETFQGYMFQLEFMNPNNWAELGVTPNREERSVFQVVQSDENAVRLSAPDHDGSDDYKLILHRGHWIYFTGELTNKDRNTQLNFPMGVKNGVEYYVMWFGSTQNDSGYLSALNVNGKGEGNVKDSGYTAWLRFVKEDDDQDDEELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY52</accession>
    <name>A0AA38KY52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_274543</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MU793444">
        <property type="protein sequence ID" value="KAJ3782963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY52"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="214"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3782963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="931" mass="102829" checksum="C35A693B2BF8E2F5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYH5</accession>
    <name>A0AA38KYH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_316788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="MU793419">
        <property type="protein sequence ID" value="KAJ3783443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYH5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="576" mass="64232" checksum="A8CBC40848CC0972" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYJ2</accession>
    <name>A0AA38KYJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fragmin60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_50744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793414">
        <property type="protein sequence ID" value="KAJ3783563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000043">
        <property type="entry name" value="macrophage-capping protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="306"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="398" mass="44074" checksum="8860242539831B9B" modified="2024-01-24" version="1">METHLTKPTKYDIEDSNIALLGSDLEKRVREHGGDKELAWNEAGTSTGLQIWRIEKFHVTPWPKAQEGKFYDGDSYIVLYTYKKTPESESFSYDLHFWLGEETSQDEAGTAAYKTVELDDHLHGIPVQYREVQGYESDRFLSHFPLGFVCLKGGISTGFHHVTDMPPVDTHKLYRISITSNPHPSQSHAHLSAIREVSFAGSSLVEGDVFVLDKGTKVWQLNTKESAGKEKFRAAEFVRSLSDGRKGGCEVTVFDEGGHGAGIFLAEFGEDTTIHRESPQSASEASNFKLYRLSDASGTPTFSAIESPITFSSLSSSDAFLLDNTLPSSSAAMYVWLGAQSSLTERRLAMQYAQKFLHDKFGDDVTSTKSKKAVAIPIVKMQEGQESEAFLTLLGGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZF5</accession>
    <name>A0AA38KZF5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_195529</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041368960" evidence="13">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="336"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3785498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="475" mass="49435" checksum="2A0FA897F2498D42" modified="2024-01-24" version="1">MRSAVIGLTVGLWATATNAHLAVFTKGMWCLNGADGNNLNSDDPVTPLYELEQSQWWFHSVNGCNNQPPADGDILTLPAGESITVEIAANQGVTTLSFDGQYVSDWPDGQSYPDNYNVPTCITSPNMHTQNQSMAAGTALAIAYVSDVADVTPENLVVFSVAYNTPWKRLTTYEIPAELPACPEGGCICAWGWIPNACGEANMYFEGIRCEVTPGSNPKPVGTPKPAVWCEDDSSACVTGPKQMLFWHQASGDNIEVTGLDLAGEFKSPGYNAKCGFSDGAQNDIFDESGTVSSVASSSASAAATTSSSTSSAAAAAATSSAASAAVAVNIANPTTSSVDSATSSTDASTSATDSSTSATDSSTSATDSSTFATDSLISSSTDSWTSSATDSWTPSSSWTSSSSWSSTTDAVLSSTSDTSTSFPTSVAAAAAASTSTTSDGRRCKRRESRFTKRDMNHRAASSHRRNAHKHLDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZL5</accession>
    <name>A0AA38KZL5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_186817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZL5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415:SF3">
        <property type="entry name" value="GNAT-FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415">
        <property type="entry name" value="SPERMIDINE N(1)-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="158" mass="18022" checksum="F50059B36A377482" modified="2024-01-24" version="1">MFETERLRLRELRQSDLSLVLEMFNNYEFQENGGVDYTVPRGDNFIEGWAGWAKSCFIALKISVTKNRDAEFTIGIIASEWGQGFGTEASRWLIGYGFRGLNLHRISLTVTATNDRAVAVYKKVGFVEEGRKRAAMWSQGKWVDHITMGILEEEFLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L075</accession>
    <name>A0AA38L075_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_426870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L075"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="252"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="612" mass="68060" checksum="6F183F0EE37C4E5A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3J6</accession>
    <name>A0AA38L3J6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_365619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793525">
        <property type="protein sequence ID" value="KAJ3781780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3J6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27458" checksum="311AC9340B0ED338" modified="2024-01-24" version="1">MRNVYNGRTSLPGNDDDDSPTMVQISDEHTSSTSSSLVPIYQPRARSDPRSSSAISLPPPSALHSNGSSSTTRSESRRRVDERELNGYNEKHRILTDDDSQEDLVDHDAHEPNTSEGESNQRSAVLRGVTGPAHSGKALLALPAPSETLRLNVQTRFRPFGGMSGFHELVTRSMKSFILIVKVFHLTAACECLSTSIYRPEGGGFGLATMIIAIVFAMADTWFDGLWSSVLFGLAHVVVARIGCFYTRELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4H2</accession>
    <name>A0AA38L4H2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4H2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="103406" checksum="C610208108BE5EB3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4I1</accession>
    <name>A0AA38L4I1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial ATP synthase g subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_50808</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793415">
        <property type="protein sequence ID" value="KAJ3783520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4I1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="181" mass="19870" checksum="E8C4E4796E771116" modified="2024-01-24" version="1">MLRPSSFRPALRSRAVRSTRFASTGSNPQLEAAQKKAQDVFSSTQQTATKAFENAKKIAGPLGETAGKYLARATKSAGPLGERAGKLMGTYKEPVLYNFTVFREILKQVYRAEGLSPPSSIDVVRSAYRTMWTNATSKAFWQKTISSGEVARLGVYALEAYGIFKIGEMVGRRSIVGYKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5W2</accession>
    <name>A0AA38L5W2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_267972</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5W2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="919"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="1042"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="232"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="615"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="792"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="690"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3786070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116359" checksum="6765015393E64BB8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5Y3</accession>
    <name>A0AA38L5Y3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_307630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5Y3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="31"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="418" mass="45145" checksum="351A4D8BC3F1BAE9" modified="2024-01-24" version="1">MTTMTIMNMNHYDHHHHQPRDVQVARRTDNLIAAAWYAGWHQDSTPSFDTSDVSWEKYTHMIYSFAVPTQDVSQLSLDGSEGEKLPQFVQVAHQNDVKALIAMGGWAGSVYFSSAVGSAENRTTFVKTVTDFTSKYGLDGINFDWEYPNKQGIGCNVINANDASNFLAFLQELRQDPVGAKLSLSAATGIATFSGPSGDPLTDVSGFAEVFDFIAIMNYDVWGSWSATVGPNSPLADSCAASENQQGSAVTAVKNWNSAGMPLDKIVLGVASYGHSFVVSHDNAFVSGSNTELAPYPPFDKSAFPHGDSWDDDGGSDACGNHEPSGGTFNFWGLINNAFLDQNGDFVDNIPHRFDSCSQTPYVYNPGSNIMVSFDNAQSFASKGKFIKGVGLGGFAMWEGGGDYKDILLDAISAATRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L605</accession>
    <name>A0AA38L605_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_352246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L605"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="35263" checksum="0A701C48AECE0EF0" modified="2024-01-24" version="1" fragment="single">KKKKKKKKKILGLSVRALEVTREDNFSLRGDTLRSALEEDKKKELHPFILIATIGTTSSGAVDNIAEIRTVTADFPEIKIHVDAAWAGMALVCPEFRELCFLEDINAIADSFSTNFHKWGLTNFDACPLWVRDRKYLTDALDITPPFLRTAQGDAGIVVDYRNWHLGLGRRYRSLKLWFVLRGYGVEGFQKHIRKAVDLNKLFVELVTSSNMLSLCAPPSLALSVIRINPKPSASNQATLPEDALNDLNKLFYGKLSARKDIILTQTVLNGQFCIRLAIGSAFTQEVHIRDAFELITHEAKLALEAWEQPQIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L631</accession>
    <name>A0AA38L631_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_108249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L631"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041417009" evidence="1">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="260" mass="29089" checksum="EF2BC47FDA4D7E33" modified="2024-01-24" version="1">MRFYNVLAFLSTFVAVSLLPQSASACEGPCITNITNEYIEKYATPMKTLMDHTNLQLASRFNLLSSTNCASHLKDAYAKVAYASLENAIFPSYFHGKCQQRTANGTLVNPPGCPNPDCPVVCGTPGSMVHFFPVLRNITVKAHEDIFTLLIKQDSESFQDVKTCVLDAMPTKKCPKESAHDKRSISRLFAAHISRSSGRHTYSGILPRENCYDDAIFEKDLYDVLQLGMVQMWSDVCDARKDFANCSWEKAMKAFILQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L677</accession>
    <name>A0AA38L677_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_432126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="1571"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1373"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1678"/>
            <end position="1770"/>
        </location>
    </feature>
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        <location>
            <begin position="971"/>
            <end position="1169"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1384"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1408"/>
            <end position="1430"/>
        </location>
    </feature>
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        <location>
            <begin position="1455"/>
            <end position="1466"/>
        </location>
    </feature>
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        <location>
            <begin position="1477"/>
            <end position="1486"/>
        </location>
    </feature>
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        <location>
            <begin position="1523"/>
            <end position="1532"/>
        </location>
    </feature>
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            <end position="1696"/>
        </location>
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            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1747"/>
            <end position="1770"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1770" mass="198000" checksum="405D5E05F7159C4A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBJ3</accession>
    <name>A0AA38NBJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_379681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793577">
        <property type="protein sequence ID" value="KAJ3781291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBJ3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="383"/>
        </location>
    </feature>
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        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="932" mass="102849" checksum="56A68A4AB528D8EA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBV4</accession>
    <name>A0AA38NBV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_364577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793498">
        <property type="protein sequence ID" value="KAJ3782116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="343"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="55128" checksum="B265406121775113" modified="2024-01-24" version="1">MESYTNAYRRNHSHSVLLSSSSLSSSADVYDYGPSICSNESELIPHGYRISRFSPPIVRSTNHTSSETTFVAISASSSHTYQTNTSQDVLPSLNNSAALFTSSTASHNGPGSSDAIVKPSSPANLLAARYGLPQALPRPPRTTPHTIMSQEKSLPDFESLRSNYISMLANKPTDNIPTHTTPVNNTMSPVHTPAEMPPPPVPQLKDQEAALKAVVDTLIASPEYQMMSGFSEYLSSPFSTPYDDFNVSPMDDSPFAPDLSTPIMDAVDEEFGWSGMMTAMDEPLFDDDASALYNMLVEAAPAKEVAPAVSATELLNNKQLYTMSPSTPALEHVNSLYSSPRFPSVNAPAKPSSSSSSTRKVSLATGTRRNITPDNLLPLDAPTQSRRYVTPSSTSRKDVSPAKKRSRSEAFEGDDEVHEDEIAPSKPPGPDATEMEKLEYKRRMSTIAARKSRRRKLEHKLMLEATVEELERDKEKWKMRCKVLQEVLKSHAVDFRFEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCC7</accession>
    <name>A0AA38NCC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eisosome component PIL1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_48254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793412">
        <property type="protein sequence ID" value="KAJ3783586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF6">
        <property type="entry name" value="EISOSOME COMPONENT PIL1-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="87106" checksum="098708577F60DD16" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCK9</accession>
    <name>A0AA38NCK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_395797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCK9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="122"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="325" mass="36083" checksum="E31EE84161C55A8E" modified="2024-01-24" version="1">MLEANRRAHEHGIDLSKLPQLLDMNADTITDNVHAINANCTNDRMKFVFKHLVQHLHDFVRETSITTEEWMSALEFLKDTGKMCSDIRHEYILLSDVLGVSSLVDSLNHAKPPGATEACVLGPFFTEDAHEFQEGDSIASEGKGEYLYVHGKVTDTKGKPIPGAIIDTWETDGHGLYDTQYADRTEPDCRGRLFSAGDGSYAFRAVVPVSYPIPSDGPVGKMVSALGRHVFRPAHLHMQIDAQGYEKLTTAFYPRGDPYLYSDAVFGVHSSLIVDLESVTDKDLSLKRGFKDGKPHMELHRDIVLVTPEEGLAARKTSMPAVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHB1</accession>
    <name>A0AA38NHB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_391354</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793903">
        <property type="protein sequence ID" value="KAJ3780122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHB1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="242"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3780122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="38932" checksum="6F6B4F0AAF8F69AD" modified="2024-01-24" version="1">MNEVEDEKKPFSVNPQEDDLLPDPDETLMLNQGHGKVWMVKIPKFLLERWAAVNAEDVHLASLRIYTDPGPGQKTRIVLFLPQQNDPTTPPNPSWPMFGPNALQSLSDAEPDCYELDMVNDNVENHIVVAERPKDASFGLSSNPSAPPNPRARTTILTGRIKHDCSLRPAFSARYRKQMRERHKKYNTPQRQIQMIENAGVAGGRGGINRLSSGVGMGAGGAFRDLVATNKKPAKGTFERMARMPRNQLFDALFALFRDTPRWSIKILREKTQQPEAYLKEVLSEIAYLHRSGEHNGLWEVKDTFKTDGIKGENIAGPSMLGDDVKMEDTNSFEDDDEDEDMEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHF4</accession>
    <name>A0AA38NHF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_369421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793738">
        <property type="protein sequence ID" value="KAJ3780437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHF4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28150" checksum="AF5243A4BB5DE2B6" modified="2024-01-24" version="1" fragment="single">MQGSNGEPSREIQSVLMRHHSEQTINSSDTDTPCPLIHQFPVEILARIFFECLPDPMSVPFDCAQLWTLGRICSRWRSVICLEMPLTWSTIKINFRSSTARAAKLSRHSAEIMRVCIQRTRECPLTIAFTCASDVGATARDDWLRSRVLSRLLPAKGRLKSLEVLNLSLEPQNARSLPRAVDIFEDAPKLTRVTMSSHLSLDTFRLPWKQIIEYRTKLMEVWNCVEVLHHAPHLRALHAKLERARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHT1</accession>
    <name>A0AA38NHT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_276978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793527">
        <property type="protein sequence ID" value="KAJ3781757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHT1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="492" mass="54154" checksum="1178B79D3B554C0B" modified="2024-01-24" version="1">MPPLRTHDAPPQVVESDTESPSSPTLAIIAPTPRSFTFPVSHTLDAPTFSTPSTSPFEPGLYSSHLTSPASSNLLTTPPLSRTLSPNPSVSSVSLLSIPSTSSGRKSASLDAERRPRKGDNAYIKRPENAFILFRRKCCAEEEASRQDDTKKRRQADLSKTISQQWKALSAGERQYWEDRADERKKVHQEMYPDYVYRPQRVRDHDGKARNRKYTKRKTTTGKQGDLNGVSAYVIPSASVGRSTSAPTPPPSSYQTIHIPNMFPSYASSSLLPMISQRTGYVGNADGIMANFDFYPDNLPAPHGNPHFEAGLQPSELHQNVFNFSGHDSMWSGNRGEAQLQPPSLNIDSLSISSSAASSPISGPFTPSSSVLSYPPSGFGGWTGAPRSDTWDFNQQMSANMDVQAGVPTSHEMDGFFNPWDPSEVWQREQSVLLRNDFDLDVIPPIELKIPEYPDSAACIGIPSEDLEAGGYPRELRDYSDASYGSEFWSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI06</accession>
    <name>A0AA38NI06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_389828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="MU793473">
        <property type="protein sequence ID" value="KAJ3782492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI06"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="302" mass="33494" checksum="462617738B90FED1" modified="2024-01-24" version="1">MSLPSAILNELAKVEPAATFSGRLGGRVKSSNENLYFVKSGSSDEVEQYTGETDSLKAINTGAPGLAPTVFASGVLEDGRPFFISEYKDIGHLTEKGASKLAKRLAIELHAYRSRDGFGFKVPTYCGATRMKNGWYDSWEQCYSEMIGDLLEILEKRGRYQELCTKGQSIRKEVIPKLLGPLRVKPVLLHGDLWSGNVGVDSATGEPVIFDPSSFFGHNEADLAIARIFGGFPPSFFGEYHKHLPKAKPESQYELRGHLYELFHYLNHTVLFGGGGYESSALRKMDLLMNAMQNHERDMQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI15</accession>
    <name>A0AA38NI15_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_396760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793464">
        <property type="protein sequence ID" value="KAJ3782612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="282" mass="31899" checksum="0D32BE4FBA5E1CDC" modified="2024-01-24" version="1">MVNTHSLSQRQNDQIVEEEDVELGLDSVFLEAPRPPSPQATFSTYQAAHKSFRIQLVGSHPLWGHHLWNSAISVASYLERHQSLCYNKNVLELGAGGALPGLIALESGLARKVVITDYPDPDLIQNIELNVQENVDDSRKDKVAIQGYIWGQPIHPLLEVLQDQDETASKFDLIILSDLIFNHSQHDALLKTCNIALKPSQSQGDCSDSPYSSFKPSMLVFYTHHRPHLAHRDMEFFDKAREAGWDCVKIVTQKFTPMFPEDPGEEEVRATVHGWMLNRKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI65</accession>
    <name>A0AA38NI65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_389380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793439">
        <property type="protein sequence ID" value="KAJ3783047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI65"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="478" mass="53645" checksum="430D40DC49B75FD6" modified="2024-01-24" version="1">MTSLLLSLPDDILITILVALNAQDLISISLTCRALYVFCASTDYIWHTIHIDFPLNLSHQTIADISPVQLQKHCVDGLRVEYNWRKNPPRLKALSRIEHGGIVDQIQYLAPQWLVSMARVSTSLGPTCVLSIWDCNISGDVKRIERISLEPRGLSKFSATLSEDRTHVLIVIFGSPRAEILRVYYIPLQTDYNADPDKYITSRLMANDVAESVFEADICGEIVSCLIARFDMGQPVYQLLFLDAKSGRHLRINVDVPPPFTKLQVRLFPDSFLLLSGVEGPQNLVLRIYDTTSILKGLKHSNSDFSASRQSLGTPCAKYSSSALGSRSQEYKLSASHLSTVAALIFPSGTSNRFVRFPVHSDNEGITRFGHQSELQSHTFHKPRNVETYPEFISLGHRGQRAVWLERKWDEESDRIRFNLMKGSFPSDHSGDVAVGPLLREHIALPFVVDTCQSMAFDEATGRIFLGLYTGEIYVLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIF0</accession>
    <name>A0AA38NIF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_360100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793407">
        <property type="protein sequence ID" value="KAJ3783722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIF0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="23831" checksum="46F5E4B08CFAC59F" modified="2024-01-24" version="1">MIPNVQMSGLRLGVDQQPKGTRTSPRLESKDDDGRNGRSRSSTLGSVYFEEDEDEEYGAEKRPRKPASQSLTTGSRSRRSRAAASRSGKRPVTSEEEEDSALDQSVETLPPPITSPSKPSGKKRKVNRYPCPVPLCKETFTRRNDVRRHIRNAAVHRDSPEALALLGEAVGAGTRCKFCNADLSRSDARMRHERASACGKRTTQKMKDQMLMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIW9</accession>
    <name>A0AA38NIW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_422351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794186">
        <property type="protein sequence ID" value="KAJ3779809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="49"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="295" mass="33078" checksum="E4CA2AFACC99A363" modified="2024-01-24" version="1" fragment="single">LEILSQKAVAGASHNAEQRHPLPNCHPGTRTQILEILKEWITNDHKSTSIYWLYGAAGVGKSAVAQTIAETFEKHTVNGIPESRLAASFFFSRADPSRNNLSLFFTTIAHQLATSPVLGPHLGAYIDLAIRHNPNILHETLEQQFQELIVNPCAKLPPDTWKNLPRLIIIDGLDECADIASQERLLSIIRQSKTNTDPPFPFDFLMCSRPEPRIRNAFRHPDFHSILDFNDLGESFESGTDIAVRDREFGRIRQGHGRSMAHVGPDWPGDGIIQQLVQRACRQFIYAATVIKYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ17</accession>
    <name>A0AA38NJ17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_381214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793931">
        <property type="protein sequence ID" value="KAJ3780079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ17"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="250" mass="28972" checksum="3017EA912A52BD0C" modified="2024-01-24" version="1">MRDRDANDLDKIAENVAEKNQQKQNQGNQEVMVHKGTPVNEAEARCRSFNRLVILWENEPSDWNTVELAWVWYRVSSVLFIRGINHLQHPPLHAFPTALYNCFTELTPYYIRQIPSPVLAEAAGWNPHVLHHLCTRRPELVFCYKEYANSETWVVYFSQQGFYSHTSLTSAIEDILRHWYDDPDPRNNDRWRLGNEVGDLLVRTGIRCEFVVGGMSFVREWLTGGGFVEAADDEDGFVNDNDGRDLEDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ72</accession>
    <name>A0AA38NJ72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_417050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793786">
        <property type="protein sequence ID" value="KAJ3780334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ72"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="88572" checksum="601FD740FCF396F2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLB7</accession>
    <name>A0AA38NLB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_330691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041342317" evidence="2">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="215" mass="23101" checksum="480688B53A6098AE" modified="2024-01-24" version="1">MHLYRALIPFVTLALALVANSTPVGYHSRASDTYARDVISYPADSGHNIRDVYPSTHFSEARSSSAETDLFVRESPPPAYVDESPPPYESPPNHPVGEPGPAPHDAKLPIDTKTPAKEDEKAPATPAKAAEKPPFSPMPKPLAPSGNKPKGVSHSLKSKWNQYSDKEKMRILTAAIGGGGLVAGATVLGVELGFRCKRDDLATCPNEPQHWKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLH8</accession>
    <name>A0AA38NLH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_358441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793384">
        <property type="protein sequence ID" value="KAJ3784249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLH8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="337" mass="37333" checksum="BE94DCA768A0B11D" modified="2024-01-24" version="1">MFFSRKVITEDQLVDLHGKVAIVTGGNTGIGYATIEFLARKGARVYMGSRNQGRAQKAIEEIEAKLQKSGDDNQASIHWLQLDLLDPRSVKEAATEFIAKEERLDILVNNASHSPFGPYYLNQDGLLDVMVVNYISHFVLTETLLPLLRRTAALDDSDVRIVNVSSTSHTYVTTDSFVGKENLNKQFGDTLTGYLITYENSKLANILHIKNLQTRLNAQSSPITCLAIHPGAVMTVGVSGFLNSVPFFGWFLKVILGPLFLTSWTQGAMTSAFAAAGKEVAETRKSKDEVERRKYEGGYLVPVANVAEPSTYAKDERLQRELYETTIEVLGEMGIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM98</accession>
    <name>A0AA38NM98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PalH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_353258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM98"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041456983" description="PalH-domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62907" checksum="E7F6A8A684D25102" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMG4</accession>
    <name>A0AA38NMG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_374588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMG4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041404498" evidence="5">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="112"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="322" mass="33512" checksum="C7610FACE6767E01" modified="2024-01-24" version="1">MLRCSSFVSILLSASLLTSELSLAAPLFGFGSSDDNSAGTTAVSNDTVTSDFLRPAFFSRIAYCSSDAVQSFQCGAPCDALGSDVDVFQIGGNDGTIPMYFIAHDPSTSTIVVAHQGTDPDNLLSILNDAKFGLVDLNTTRFTTADGKGIQVHDGFQQTFERTADGVLAGVQNGLATTNATNVLVTGHSLGAAVATLDAMFLKEKLDPSVQLTTSVFGLPRVGDQAWADFVDSSLGSTLSHITNQNDPVPTVPPEFLGFVHPSNEFHITGVDSNGQATGIVACPGQDNENCSTGNDILDASVANHLGPYFDDISFGASACPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNR4</accession>
    <name>A0AA38NNR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_85175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="442" mass="49758" checksum="436D34E19F12ADEB" modified="2024-01-24" version="1">MYTTTIDPVFDIHSLPNEVLCQIFLFVVARNPGEYSVSELQLSYVCSRWNAVALSLPSLWSSICVLAHEDSEAEAVRRLTELYLGRSGTEPLDLFLHIREASSLMDLLCTQAYRWRHFHLVTKAHRNILDLGFTELSLLESLSLALDDQSPLNTASKSRMWFNAPRLHTLSLDMTLFELEQFELPWHQLRHLTMEYLNLDQMHKALCLCTSVVTAIFSSCANDFSFRDPAPYTCLFLSSLTIIASHRLETLGPDITHCIYPSLSELTLISGSQEFSFSHGIVPNLTSLVIRSGCRLTSLTLHGISYSSKHLMELLQAISPSLVKLDLCDVDHLPGSGTSLSQIPGYLLPQLKEFGIRFPGSRRDESIDRVKLSEVLRMVESRRPSPTLVGTQSRSIVNDSDTCLGTVLEKLHLGRLWNARVPLEFNNRLRALKDNGLEITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP37</accession>
    <name>A0AA38NP37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_362571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793449">
        <property type="protein sequence ID" value="KAJ3782855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP37"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041276745" description="CBM1 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7577" checksum="8C8D36E966B84C4F" modified="2024-01-24" version="1">MGFSFKFAISLFTLQLIAVQGLPAEPRAGIDICGFDGTAPYCPQGFVCCGPLLEINGTTYGSSCVPENGACPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPF5</accession>
    <name>A0AA38NPF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_293973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53283" checksum="F1AF2AB1AF3523B7" modified="2024-01-24" version="1">MAKDLPGFYFDIERNRYFPLSSRPSPVIAEGSSTQRNALLHKRPCVETEPWPTTTPSAIVHRTRNLLSSEALNQRILNSQINLVTQGRSLLNHEVQCSRLASTSRFDFSQTASFGNITEFCSATSEDGLTRRYIGDDKGWFYTCTVYSDVSSDNRLQDLNHYPPIETPSAQMYMWPPEINLHSLSQVSSIKISGHNCVTTCFGPVTKVAVQDLHASGRTTLITFNQVHDVRASHFQDSTLILGAKGKAVHIPNIDVSGSVQYLNNPQNSDIFAVDRDKNLVYTGARNGSITRHDLRVPSEKNGQWLFQSRFSAGKDNTVPSSVLYLKLVQDSQLLVSQMNGELCTYDTRFPMKNTPSRIFRGHRNSVTQKLGICLDPGNDFIFAAGEDHRIRGWSLRTGKALHDDSSASASASATSISMASSSSCSSWNQFRSPFKTSFPTPVPTMQVTEERDGSLCLWAGSQQTLYRYFLGQYSKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPK1</accession>
    <name>A0AA38NPK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_355322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPK1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041448261" evidence="2">
        <location>
            <begin position="28"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="277" mass="30754" checksum="6CE858583A6B4A54" modified="2024-01-24" version="1">MHMHPFPCGILLPILLVLGTFTCMAYASPISEIQARAGSTSSSLPAPSPRFSVIANLRNKFNGKSKKSGPSKFSSLKHHTVGYGFTRSQGIGDATEVPLSKINVKLDDTAQSEHDVFLVPTPNYAFTDQSLCMIYTTQAGLNKFKTLPMIYEKDDIYRLPPYELDKQPIDFFAARVRNEKAITIAMHIPQIHVGKAEEIGLHTQCLTRPGSKRPALWAEAEWHKYKVPGWPAKLRASSHPGEPTIQQHQLRDSQSHTASHTASPYQHTEVITGVRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQU8</accession>
    <name>A0AA38NQU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_48710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="310" mass="34118" checksum="E8482C725F1C6C94" modified="2024-01-24" version="1">MMGEDDASTRNNASWGNRAIPQINSLPSPPLLRTIMNGAPSTVHRADLFFSTPPPIPQNRPSSRHSYSAGNSSAAQNPRLPLKLNRSRTTSPQTHLDTFMPPPPPPPLKFHSQSTPDSPADQAELQTIIQLSKSESERQDLLLEKLSNQEEDDLAQALAESIRMSEKTSISSPVAGPSRPPVVPIHTRPYSQSLPSPSRRSCESRQLIAVNEAVPANGNRSKSLEIEDPALATWSSPPLNSASLLDDEALARQLAQEEAREEERLRESTRISTENLQPALEDDEAFARQLALEEEEDDKHEETITPAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR06</accession>
    <name>A0AA38NR06_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_343066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR06"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="204" mass="22498" checksum="8DE19A8531FA6953" modified="2024-01-24" version="1">MAPYLQTIRSFADVPVTDAGVDTLIFLEASQGVLGLFDLLGSTAFAAVQSDLKGNIIKVRARYDATPAQSATLEELVKNEQGEKKRTATEGLMWLLRGLAFTCTALLNAQANKTEELTVAFTKGYERTLKQFHNFIVKGIFSVAMKACPYRKDFYAKLASDPAGGPAVSESILNEELDKWLAALDLIVKRMEAFYEKHGYNKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRB0</accession>
    <name>A0AA38NRB0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AtMMH-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_371886</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRB0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="12">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="353" mass="39609" checksum="3C4B983BAD40C621" modified="2024-01-24" version="1">MPELPEVERAVKHIRRIGLNKVIERVETTEDNNVYSETTHEDFANEITGRMITGVKRYGKSFFLELEGKGKLPVLHFGMTGMLQVKGEKAMYYKETPRSAPSDWPPRFMKFILHLRDGSTQETAEIAFMDARRLGRIRLRDSPATEAPISELGFDPILCMPSLEVFEALVKKRACSMKALLLDQSFSAGVGNWVADEILYHARVHPKQRCNTLTTTQIGDLHRCTKFVCETAVSVDADDTKFPEDWLFKHRWGKGKKIKAEPLKLPSGQPATIHWVTVGGRTSAYVAELQQLSSHAPVPLSKQRPTHSSLLDVDGNSESESDLPALTDSDSEILPSLSKKRVSIIIIHSLMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRG3</accession>
    <name>A0AA38NRG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor, Prp19-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_383934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRG3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="144"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="954" mass="107502" checksum="B0EF20D6272E38D8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRP0</accession>
    <name>A0AA38NRP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-finger of mitochondrial splicing suppressor 51-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_383769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRP0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="207"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="399"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="555" mass="62443" checksum="D69097EDBC05CD68" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRU0</accession>
    <name>A0AA38NRU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_259697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRU0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14334" checksum="F9E6737738CB2807" modified="2024-01-24" version="1">MEEDLIGLEDLEIDLKRFYYAHDNDQKNTGRLVQNWFSEKNLAQLKWPASSPDMNIQEHVWAELEAIACRYEPAPHTEDEMWEVLQWAWSEISMEFIVNLYASLPCRINALIKAKGWNTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRV9</accession>
    <name>A0AA38NRV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein P1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_303929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRV9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="110" mass="10983" checksum="7BABB717EC20974C" modified="2024-01-24" version="1">MSNTDLAASYAALILADDGIEITADKIVALTSAAGVELEPIWASLLAKALEGKNVKDLLSNVGSGGGAPAAVATSSAGGAGAAAAEAPKEEEKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRX5</accession>
    <name>A0AA38NRX5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_341447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039228">
        <property type="entry name" value="SZRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796:SF2">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="177" mass="19493" checksum="A7937753BE1D31BC" modified="2024-01-24" version="1">MPDDSLGWGEPDPPPTSRRPKAPPEVVRDDWEDDDDEEEPQEEKNKKIWHKANHEAAAPMPTFIVSSSNVAPPPVAAFQPAFKILKRPVNSSETSSFPQSYTSKESLEDREARYQVARNRIFGATSGSDTNTVHGVAQKDNAAIRDPRGPNEIQNPLTDTAAAKGRPETPNANQVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRY3</accession>
    <name>A0AA38NRY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_259271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="121" mass="13433" checksum="4913C37B167538A0" modified="2024-01-24" version="1">MQPARTDLLPPKDDPFTLNELKQYDGTTEGMPIYVSIKGTVFDVSHKSDVYGAGKSYNIFAGKDGSKGLGMSSLKTEHAVPDYSGLDEKDMKTLNDWHAFFIKRYNIVGRVSDLPDAVKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRY6</accession>
    <name>A0AA38NRY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial small ribosomal subunit Rsm22-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_304118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3790023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="636" mass="70669" checksum="73764961486A05BC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRZ6</accession>
    <name>A0AA38NRZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_259267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRZ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="33"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="357" mass="39332" checksum="3B05021D4526E2DA" modified="2024-01-24" version="1">MNATPNSLLPSPTSHSLPPTSKTSFTDSRPFWLTLYFFFNLGLTLYNKGVLVRFPFPYTLTAIHALFGSLGGAILARFQVFVPPRLKKNETTVLLAFSFLYSINIVVSNVSLQLVTIPFHQVIRSTTPIFTIMFSALLLGKSSSRWKIITLIPVTVGVGLATFGDYYFTRWGLILTLLGTILAALKTIFTNVLQSPLPSLTDLTPKSFLSQIYPFSILAQARLHLNSLALLSLLSPLAFVQCMVLAYLTGELDRVRTYSQQELTGARLMALALNGCIAFGLNVVSFSANKKVGALGITVAANVKQVLTILCAVMLFHLNITALNSLGIILTLLGGAWYARVEYMEKQEQQQLRNRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSU8</accession>
    <name>A0AA38NSU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_302828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32619" checksum="2BD8BDDA7091494D" modified="2024-01-24" version="1">MNDESSQRYYASKQYLLPADNVETKRLDTQHDMITNVFGGRLSMAPTTLITGDRVLESAAGSGIWALEFFEKNCADGIILNIDCIDISSAQFPTTHPPQIHFSVNSVVDLPNPEWSDTFAYAHQRLLVAAMNDSLWRSAVSELFRVIRPDGWVELVEIEAQDFSSWSVGPSSTKLASLINAMYGAKGVIGDLSVYLPAILKEAGFTDVKCDKRRASIGGEVDATPHKVTDVQGYSSGMWRELWMGMKGPVVEAGGYGIVETVQEYEALVESSAVEWKASKEAYTTFFVILAHKGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSX9</accession>
    <name>A0AA38NSX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_340228</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="16">
        <location>
            <begin position="312"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="121"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="518"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3790481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="556" mass="55681" checksum="60B176B0EAE9528F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT26</accession>
    <name>A0AA38NT26_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L18e/L15P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_339818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="186" mass="21028" checksum="024E70528F0CBFB7" modified="2024-01-24" version="1">MGIDLTAHHVKKGNRTAPKSEDPYLLLLVKLYRFLARRTDSNFNKVILHRLFLSKINRPPISLSRIVRETSKTPDLSSKVIVQVGTVTDDIRLNEVPKLTIAALRFTQSAKERILNAGGEVLTLDQLALRAPTGSNTVLLRGQRNTREAVKHFGMGPHKHKKPYTISKGRKFEQARGRRKSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT66</accession>
    <name>A0AA38NT66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_340004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT66"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="45"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="547" mass="61682" checksum="185BBC25A9357129" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT76</accession>
    <name>A0AA38NT76_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_371012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT76"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="898" mass="93620" checksum="D78F06E88ADDD339" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTD4</accession>
    <name>A0AA38NTD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Restriction endonuclease type II-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_130667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="264" mass="29557" checksum="57BDB62DED763A92" modified="2024-01-24" version="1">MSSSSSLSRPAPPVVIPGSGNHIILNPLQRGNPVLECIRNVGKEYGDIVADYQVGRTTGVLFLSLKYHRLHPEYIHTRIEKLGHHYTLRILLILSDISEHKDPIRELTKACLTNNITVIVAFSFEEAGHYLTIFKQFEYKPPNMIKERADKDYISMLRTTLTSISKVNKTDVETLRNSFGSIANIAKAQPEQLANLPGFGQVKVKNIKNAFEKPFRNHATNTVSFMASSQSEAGNTPHDEQTEPGPSHNSVRDPSPVWDIELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU55</accession>
    <name>A0AA38NU55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_338121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3791193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27090" checksum="8806856A25486F78" modified="2024-01-24" version="1">MNMSGAGKTAIVTGASSGIGRYSAIALLNEGWNVAITARRYEALQETQKMSSNPGNCLCLTGEITDEDFVMKLFDQTVSKFGRLDLLFNNAGISSAQVPIEKLSLDDFQKVLSTNLVGPFICTREAVRQFKTQSPPGGRIINNGSLSAHVPRPYSYAYTISKHAMNGLTKCTSLDGRAFNITCTQIDIGNAATEMGGRHGVGALQPDGRTIQEGVLDVQHVASTIVHISSLPPDVTVLNVNIMPTDIPYIGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUB6</accession>
    <name>A0AA38NUB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_2496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUB6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3791301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="42183" checksum="E314FE9041FCD206" modified="2024-01-24" version="1">MGGSAFKLLQTSSFPRLPSPVYQALKARLTPVLQQLYDYVAVPAEAPEKMDHGDLDFVVYQPRLSSSHCLTPGLVNAPHQQVKTALGASHCILEDGNRTSNFAIAVDRGAWGSVGCAEQEENFRQVADEHVIYYQVDVHVCADKNEWERVVYFHSYGDLGMIQGLVATNVGLVLGANGLKFAHPPHPTLTLSQDFAQIAKFFGWSNERRSLGFNTRQEAFEWVFESRFFDLQYIRTSGKGTGKVKAQRKMYFDFVAWANERSAQSGVTSVDMEKVERRQERVREEALVEFGRRDEVATVVREFEGRKKIKNGFNGTVVDAWIGSNGNWRKVKTVMDKVRERHGGEEGILRILESEGEDGLKQRVMSALEESTSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUD0</accession>
    <name>A0AA38NUD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SRF-type transcription factor (DNA-binding and dimerization domain)-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUD0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3791201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="380" mass="39823" checksum="A634DDE4D5CB24D6" modified="2024-01-24" version="1">MQKRSRMDMAGNPADQHPHPGHPGVTEDAFINDRDAVDSGADDDEDEDKPKSDKKAGRRKIKIEFIQDKSRRHITFSKRKAGIMKKAYELSTLTGTQVLLLVVSETGLVYTFTTAKLQPLVTQPEGKNLIQACLNAPHGSLPSSMPVGAPLGRASNVGQPATAPANNIPGGLSIGSSAASGTTKEDEDSVEEDEASRGGRAQVGDKRRRRASSNAGPPPPSSSSNRGGPTASPHSVNSTIPPHLSISSGTNASQPQPSSAHPGPSPQMSMGPSPTSPQQGHAAIPASNNPQYSPSYGHHTHQHPSHQQSPDGGMYGGTPAHMMPAGSYSYAPANQPSTASGQQQLGGLAAAAAQHGHWGTAQQQQQSQQVTGQNTHYTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZ72</accession>
    <name>A0AA38TZ72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_342105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZ72"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="234" mass="26349" checksum="FBFAFC6FBAE01ACA" modified="2024-01-24" version="1">MLSKRLFSPATLRGTIPSDFHFVPDFFSMSEQRTLLSAALERLDAAESRRFQKRRKQSRSSLNTSASICEAPLSELFLPDDCYEFLQGHYDGVIHKYREMHLTSWPTAEFPGLVPALSRLQSVLPSSNIQTHLLHLASDGEILPHVDNVSASGRWILGVSLGSDRILRLESCANPDEVAEILLPSGSIYIQSDTVRYQYKHSILRNSAFTNGAGQRMSIMIRDLLKHHSHTNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0L5</accession>
    <name>A0AA38U0L5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_281967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0L5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="404" mass="43356" checksum="CDA716BE4B44F196" modified="2024-01-24" version="1">MSSKKTDSEKTTIVIVGGGIGGLALLNALSTNINPEKQTVVLVDARPTHMHLISSLRLVVSDADDLLNKAVHPYGDHTFRNKLSGNGTFIHGSVNSVKFGDSGNGGELILDNGEIVAYDILVLATGSSWPRPLGFPTDSRSAIEEHILARRAEFSKAKDILLVGGGSLGLELAGELKDVFPSKPVTIIHRERLLLNDTYPDKFRITVQKQVEARGVTVLLGDAITASDASDVSASQVPESGFVTEQGKKLNPDLVVPTWGNRPNTSYLPSDLLSSTGHVKILPTFQLPSYPNVFAFGDIIDWKEQKGAAKAAFFHTPKVAKNVMAYLDLAEAAGASSVDLMASKKSAKYTGCMEMIMITNGKARGVGYFNILWGIIIGGWLITLLKAKTLMIGRIPSQTGFTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U8D9</accession>
    <name>A0AA38U8D9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_65589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U8D9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22448">
        <property type="entry name" value="KH-I_ScSCP160_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="156"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="458"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="543"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="624"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="708"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="792"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="864"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="945"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1149"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3791100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1224" mass="133291" checksum="FE63AF9B5318A307" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8K7</accession>
    <name>A0AA38K8K7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease/ribotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_364363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793492">
        <property type="protein sequence ID" value="KAJ3782199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8K7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="212" mass="23680" checksum="F22A0A6D276FBC76" modified="2024-01-24" version="1">MIWEIPERHVDYFLRLRRSRGFYKTVIFPISASSLAAESFELLSINMSSSGITIFYEPSGCNCDGTAYTQADINAAGAKALQLASEKKTLGEDKYPHVYNDYEKFSFAHAVKPYLEFPIERSAKTYNGGSPGADRIVIGSIAEDFSSAVYCAVITHDGQKKNGFAECADDTMNPRGKGKYVPGSGDVEEHHRKHGHHGHRYGDRKLREYIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K920</accession>
    <name>A0AA38K920_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_361026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K920"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041297583" evidence="3">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="182" mass="18658" checksum="0322B0D4DF812E71" modified="2024-01-24" version="1">MRAFIFTFLTFLLAFVCAQTETVPDLDGNTVVEVITTNRLGVITTSTISTIAVDAETTSTTGTTSTTATKAATTQPQGGGVVGVPGTTNTVDPNGPTPYTYTTVVDGITTALEATFIPTFTTAPGTPAPATGTILDYSQWLSEFGSSTTATNSAPRVSSSSHVYLGTAILMAMGLGWAVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K935</accession>
    <name>A0AA38K935_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_50810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793415">
        <property type="protein sequence ID" value="KAJ3783519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K935"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="13"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="460"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="857"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3783519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1211" mass="133624" checksum="ECED8C89443ADBB0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAE2</accession>
    <name>A0AA38KAE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_421022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3786009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAE2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11076" checksum="2C92BC769568C217" modified="2024-01-24" version="1">MSPEANRDLGQVVKVLREENVLLLAGGLPIHNIQDFGSFTPDTAQPIYHSFHKAILDALQVSNCPRKEEGIDGFAPTSWIPSMQSTTQPEQARTRTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAV4</accession>
    <name>A0AA38KAV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_162706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="285" mass="29627" checksum="52DFFFFEBCD3D939" modified="2024-01-24" version="1">MSATETAVTPAEEIKPVESATETTEPTPAPIEVAPKVEEATAEAPKEEAKAEDTPVAASEEPVAAEPASEAAPAATEDVAKDDTKPTEESSKKEEAPKSPNLFAKLLAPFKSEKHKAEKKKEAASEPAAPATEEPTATEATAEVPTAEVVKAEEAPAATEEPANEVEAPTAPEPVAEAVAPAEEPKEEKKEEKKEEKVTKPAKVGRRLSARVGDFFKPRPKTEVSTPAKVDEHPPKIEQPAPVAPLENPATESAAEGPVATVEAKGEEPAADKLTDAPEAVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBC5</accession>
    <name>A0AA38KBC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBC5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="11"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="448" mass="51217" checksum="3F94CD9C168E198B" modified="2024-01-24" version="1">MSEDTTSPKVRTHILCFDGTASEYDSENTNVVKFFSLLKKDDFDDQLCYYQAGIGTFFAPGVVSPLFQWCAKVLDEAFAWYLNAHVMDGYRFLMQNYRAGDKICLFGFSRGAYTARALAGMLYKVGLLPRDNQEQIPFAYKLYTRTDHVGIKLSAGFKQTYCQNVEIEFLGVWDTVASVGVITTKTLPFTSDNSSIKIFRQALSLDEHRARFKPNLFHREPMTASGFSEIKNRRVETDPKISANLENQRKPSPMTRTLTDYFRKNKTVSPDITSLVCTTDEESTSGTDVLEVWFAGCHSDIGGGSVSNSTKESLSDISLRWMVRQVVESQCGIQFNEDALAQQFKIIGDRDGDASWKGLDILDSVQPLHDQLVLQPAWWLLEILPMQSRYQDVMRQWHTSYGWNLGRGRRIYIPKPYFHTTVKHRCEDKALAYKPKARWEEGTEIYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBP3</accession>
    <name>A0AA38KBP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_279383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793733">
        <property type="protein sequence ID" value="KAJ3780463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="49" mass="5756" checksum="1AD90FC860B35ED1" modified="2024-01-24" version="1" fragment="single">NHERAINLSILVMSGPVKLSRRLHTWWCPSVNSFKFQPCDHTPPRTQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBV1</accession>
    <name>A0AA38KBV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_380346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793677">
        <property type="protein sequence ID" value="KAJ3780658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="896" mass="100335" checksum="908B6E36D40ABB8A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC20</accession>
    <name>A0AA38KC20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_393215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="479"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="595" mass="64525" checksum="62EAFFDEABCE1419" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDQ7</accession>
    <name>A0AA38KDQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_320509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="MU793574">
        <property type="protein sequence ID" value="KAJ3781316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041202399" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="452"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="641" mass="68790" checksum="8A64A10E25207D84" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE02</accession>
    <name>A0AA38KE02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_276803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793520">
        <property type="protein sequence ID" value="KAJ3781841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE02"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001135">
        <property type="entry name" value="ABC transporter F family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="188"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="511"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="726" mass="81521" checksum="5D5E373D6F1C9EEE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KED7</accession>
    <name>A0AA38KED7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_8215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793350">
        <property type="protein sequence ID" value="KAJ3785188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KED7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="906"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="941"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="706"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121321" checksum="4CCDBC8E0B30192D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KED9</accession>
    <name>A0AA38KED9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793349">
        <property type="protein sequence ID" value="KAJ3785203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KED9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="103"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="36071" checksum="134C45F850D1F78D" modified="2024-01-24" version="1" fragment="single">MSKFSTQSVVAAFLVLFMTVASHAALKLYKYARLRRKLPNSFLQWRMPNKPDDKYAEQRVWLDLGPFFFTLGYRSWVIPDAICLYSVVPDGILPAQSGYKFIIEGIRESGAGTLKRYGFMPFKNSLLHFFLNRENQAVVIRPLTIGNEGKNQLQIIRHLSHPAKAAYTGNHILPMIREIPLDDIIFGVFPLSGPSLVLLYSYIMPQNSVGDIINMYMQALEALVFLHKNRIAHRDTFGDNFVIQWHPESLRAGQIPFLRPRVQLIDFEMAVQFPPDINMEDCVCYSLPHEGTSYSTIQYTRPFPFYHAQDTDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEQ7</accession>
    <name>A0AA38KEQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_389346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793437">
        <property type="protein sequence ID" value="KAJ3783086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43097" checksum="2AACE121AB1AB5FD" modified="2024-01-24" version="1">MGSSREYHGLQIMTACMQLIGVSLLSFCLARRVPTGWRQWRHLTWGRTCVLLILLDSWIFVFFTGLLSSGIGLSWSHTTCTLAIYSCISFYVISKILIYAFLSEKVYIVWTGGNQASRYKTKVYRLCAFVLSGYFAIGILMILGNENTVRADGVCVIGLKSYSTIPLIAYDLSLNIFLTAMFMCPLWVLHPMSPRLRSVAKRTLYGATTSLISSAVNILIMLLLSGSELGWVCITSCVSDVVINSFAVFCVSSGSYSSGTIRDRFSLPTMDMSALTFAATESSRPTAGSSTIPENCYDYLPPEHRKIVDPEKSSPLQKNLPSPTLETPTQSALNISPHAPNASSVDPSSTTFNHLDLPPPALVNNQLLKISTRSRQCTDCKWREEVNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEY3</accession>
    <name>A0AA38KEY3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_231250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="127" mass="14185" checksum="E33167A334D273B4" modified="2024-01-24" version="1" fragment="single">QAHSASYLSRLENLEKQMSASANAVRFPEKKCKNCQRTGHVAEECFRKGGGKEGQFPSWWKGKREATERPSTANATAASNEKNPEVAELTQFYGLSATSHDKTGDEIYADTGASDHFFRKREDFATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF83</accession>
    <name>A0AA38KF83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_176475</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="89"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="345"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3786253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="50307" checksum="63B2E57156BE4557" modified="2024-01-24" version="1">MIQPRVFSAIQSCRCAYRSFFSSAITSKYGHTLEILGDQYPTDEITNVTPAILSKIPLRVHTQVGHPLSTLRSIIEFHYPDFSHLSSFSPLVTPFKNFDELSFPKDHPGRSVTDSYYINKNLMLRTHTSAHEVEVFSKGEDRWLLTADVYRRDEIDGSHYPVFHQMEGARLYSADASGMKEIEEDNERLSRHLETSNIVIEDIPHISPTNPVQQTHDPRHSELVAKNLKLSLNGLLLRLFGGSNSEEPLRVRWIEAYFPFTSPSFEVEVFFRGKWLEILGCGVVIQSTLDTSNVQGKIGWAFGLGLERIAMILYSIPDIRLFWSTDTRFLSQFKAGEITTFKPYSKFPSCFKDVSFWNPQGSAPLHDNDFCDLVRDVAGDLVEDVKMIDTFVHPKTNRSSSCYRINYRSMERSLSNEEVNELQKNVVSRLSDVFRVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFH4</accession>
    <name>A0AA38KFH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_294846</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793390">
        <property type="protein sequence ID" value="KAJ3784091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3784091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="189" mass="21508" checksum="0DAA53631A7EBBB8" modified="2024-01-24" version="1">MFIINWFWDVLAQLGLLHKNAKILFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHLQARRLWRDYFPEVDAIVFLVDSADFERFPESKAELDALLAIEELSKVPFLILGNKIDAQGAVSEEELRHHLGLWQTTGKGKVPLTDIRPIEIFMCSVVQRQGYGDGFRWVSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFP5</accession>
    <name>A0AA38KFP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_427137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFP5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041385206" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="520"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="669" mass="73713" checksum="33B50EB9CFDE9C96" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKS1</accession>
    <name>A0AA38KKS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793675">
        <property type="protein sequence ID" value="KAJ3780674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="391" mass="43822" checksum="E17C32BDC5187B06" modified="2024-01-24" version="1">MLFLRKHAEEPVLTEQRFRAFVCDPSNRQLIDQWSSLAYWEGPKLAFARVLYNLWQTDPNRLRFRDNLFSEQQLDTAMTLREMALVWDRDIEPDLQKESEGVKEKPKKEFMQAGFGSSSMLRSGPLEPFPSVQSLASPWPPTCCLMSPPGLNEASQYVPQAQEITFASKKFPFAYLEWHKEIDEGIKNGKVALNLRSLSMHLAGVTITGGDSDITARQKSMNSIIVPRAHGPVSESESLTQSPNLIQAAPDAEELSFVSLFFKYYILSCQTDILLPTPSNKVNVCRDTVQHPNNETSDVPTAEEAKVAFLEENVRIYHAPVEAHSKEIETISSPSTHTLAGLGKEARLSNVTHRSVKREFRQLVRVAGPTAASQDSTKPLTIRIPPVTAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLG2</accession>
    <name>A0AA38KLG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793658">
        <property type="protein sequence ID" value="KAJ3780765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="394" mass="43964" checksum="6F1341E57FDF5F81" modified="2024-01-24" version="1">MNPDIFSEADFAPSITTSTQLHWPSSFPPIPDESCDIAQAVSQRLRKERAERAQNSNDSSSSDSDLDSDNGLDTRSPDDHMSRSFISFSSLPSYPMQSSLPSQPEGGPSFLVPGQRNSQNSTTLNEINLQRQLAEWKRRALVAEGQVMIEQAEREAATVHAVLAGREASILKYQLNANTRKKTDTSKRFTTSARIVTSAEGKEQAIAEASKRDAKKNELEEKKKKKQDTERADFLRRAEQEREQLPFSGSLRSKLKAELQDILFALGLDIEGNVAALLLRINAHFDTETALKQDPRYIGLFSKPSGKRKQAAEDHSETMQPSPPIHHSPSPIHSQPLIPPRPRPRPRIRHIVQNTMHDSTRIFTDTSPRPFGTSSPQPFGPSSTQHFNEQSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP24</accession>
    <name>A0AA38KP24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_40130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793396">
        <property type="protein sequence ID" value="KAJ3783960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="406" mass="46669" checksum="33B4854F482C49EC" modified="2024-01-24" version="1">MFASSSTLPPLPSSETGEENDPHYPLGLTPAERQWSDLYPYVARRGYHLRSRYRPGWIGSWIQEGLSTSELMLRPTWRYEYEDAVPSPGRLTVIDATRINDGAPVALKLISMSAQINTPDSNEIEILQYLSSSALAQDPRNHCIQMIDSFEVFTPAEMKELSAQGFSNAFIAVFPFARKWTDIPFRLVWEGLDFVRQVLEGLAFLHEHNIAHRDIRSENLMMDAASQCFSATYPCDRIDTPVRYLFIDLGSSTKFDEHRLVEFRHGWHKEIPEIYEMDSEGNRVPTRLYDPFKGDVFVLGMVLDVYFGKSISSLQPLFSFMQNSSPAHRPTASEALSLFHQYTNPLYTSRIHAVMPIADPSPFGDGELDFFTRWMVRTVAYLWGWIDYLRLVYKVLWEGHELRIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPG7</accession>
    <name>A0AA38KPG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease III homolog</fullName>
            <ecNumber evidence="14">3.2.2.-</ecNumber>
            <ecNumber evidence="14">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="14">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NTH1</name>
        <name evidence="17" type="ORF">GGU10DRAFT_365408</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="14"/>
    <dbReference type="EC" id="4.2.99.18" evidence="14"/>
    <dbReference type="EMBL" id="MU793519">
        <property type="protein sequence ID" value="KAJ3781851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="16">
        <location>
            <begin position="188"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="434"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3781851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="492" mass="53629" checksum="ECB816EB03FFA62D" modified="2024-01-24" version="1">MLNLTSRTSTFNDSVTLFELKRELDEPNGREPEPNETNRMCGSTPLRRKLVRNLAESESEEEEARPLKRTKLVDEPYFPSRLSSKPRSGTKSPSRNGSSSRTKTKPSEPKSPRKLKRTSSDSASSAAHPAPSNWRQVYDLIHEMRYTPSGCAWDAAVDTMGCSIAGEGEGEDGEDKNKRFSILISLMLSSQTKDVVTHAAISNLRSALRALGSSGLSAIALASAPPSLVQDSINKVGFWRRKTEYIQKAAVICRDKYDGDIPKTLEELLDLPGVGKKMAYLTLGSAWGLNMGIGVDVHVHRITNRLGWHNPPTKTPEETRINLESWLPRELHQTINHLLVGFGQTICSPVKPKCSECSLSSIEGLCPSRQLPSQTTKAAVKAMKKTTTSKSKATTSRSVTVESKDENLDSATTTNSTLTLAAAKIDWAEGVAGTSEEHANKVGDGDKKSGKTEPDRYGAAEQGATVNGKLQEETVVIERNGGPQVKIEIEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ47</accession>
    <name>A0AA38KQ47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAM signaling pathway protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_73537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793456">
        <property type="protein sequence ID" value="KAJ3782751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="807"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1135" mass="122622" checksum="09DE327351357B6B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSM7</accession>
    <name>A0AA38KSM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794633">
        <property type="protein sequence ID" value="KAJ3779562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="148" mass="16171" checksum="2D973311147EC719" modified="2024-01-24" version="1" fragment="single">MTSASDTAMSPPATLASSPVAVHPGFANSADRPVQLAAFTLQELPEVSLDWDKQLFTITRLDNEDLTVSTEEMIACILASLAMSRRWKMEQGTPTRYNEIARTLGSYIPGTSTANFSIIHNGELWKSSQPVTYNCVFSGPQITELTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSS3</accession>
    <name>A0AA38KSS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794330">
        <property type="protein sequence ID" value="KAJ3779712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="455" mass="51281" checksum="D54C58D470860B25" modified="2024-01-24" version="1" fragment="single">REITDENLKKKEFLRCFAKWSSLKDILSEISDTLTDKDWVKLNGTGSNPEDFACRPFFDAIRDKILGNDWARVYDMKREKYFMLADPTGFSKLVTLMETHNRRLRGTMYHRSNEVLQTLIMQKLPDKFRADLRDCKVSEQLPYAEWKLACKDVEERRPPTASTPVYAPKREIRNDRIMAPSAAANYPVTTSSFSASTTSKSHRFPKLQPDQKVLLNKLEACYRCYKLFAGHLSGNCPDNGPPNLSVPYRPLTESDVALANKIHVAAPNNSIPYELILKKNNTAPSATRPVAVIQDRIALTDLPDFDEVQSAPSTNLRSHDVAALYGPREVLHVSTGAGVYGSALDRGFDYNESISAPVTKPVATLVPSRRSVNDYRGGVSTGDRSPYSPPQGRNTRRREFSPDTSRRGSIEFDNRRFRSESRSPSSSGLRRTDVDSDTHEHAEGTWLGKVLAYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT95</accession>
    <name>A0AA38KT95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_310556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT95"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF452">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041486387" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="534" mass="59287" checksum="8D259AFAD8239C9C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTD1</accession>
    <name>A0AA38KTD1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase delta, subunit 4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_386286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTD1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="218" mass="24803" checksum="F4836F5B3923E257" modified="2024-01-24" version="1">MPVTKRSSSSSKQSKINFSSFKGSPAFVGKKAKLTDTKILQKDVEEVEEFSSCSESSFEHAEEIEESDATSQTSAFPLKRKHSAMIDNKDSKLDGQKSEVKDQDQGQIDNSTLTKQRPPLKVNDPRWRKLGAKAREVNGNLPLVHAEKENKIHDILRVFDLSYEYGPCYGVSRLDRWERAHAMGLSPPLEIRDILLTRQGVEDRKYAQNVFFDQTERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTD2</accession>
    <name>A0AA38KTD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_261408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTD2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3789075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="268" mass="30448" checksum="733A2686FA4A56A5" modified="2024-01-24" version="1">MNPKIPGFLQKLYTLVSDPETDDVICWSEAGDSFFVLDHTRLATERLGAFFKHNKFASFVRQLNMYGFHKIPHLQQGALRSSSEAEYPQFAHPDFHRGQEDRLILIERKKQSTMHPKDQGVVDFPTVAPQLVPQLQTVDHATSQALDIHTVINGLAAIRRHQANISSELDELKRSNQLLWQESMEARDRHQKQQNTINCIIKFLAGFYRPQAANAANKEKERGPSPVLRGSRFMIEDKKREPAPKVGIVEVQDEEATSPISRAESPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUE5</accession>
    <name>A0AA38KUE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_276498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793509">
        <property type="protein sequence ID" value="KAJ3781977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041273016" evidence="5">
        <location>
            <begin position="21"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="51"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="520" mass="56258" checksum="AB391D01B8D67F7A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVZ1</accession>
    <name>A0AA38KVZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoadipate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_270201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3785007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="580"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1098" mass="120800" checksum="ED23104D4685357C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWP3</accession>
    <name>A0AA38KWP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_255006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="327" mass="34698" checksum="082CE04613E1D45E" modified="2024-01-24" version="1" fragment="single">MLSVNVGSGSGLMGYTSGWQVWGSNSPSSQRNPSISSAASAGDISSSQNESGYRGTIREGWTSSRPASGTWDEDVTQSPLKEFSQSASFFAPLSLHSSRPRQASATPFLGPRAENRPAKLSPSAFDHTSNPESTSPRYNTAPASASATFASTPYSAPHPTTQSSTLTGASGYETLISNPSVSTVDDLSLNFRGMAVEDDYSGRPKSNPPISLPFNMMQQPQPPVSLPRPPYSNYPGISDYSYGFDAPRAPVDPSIYGSPALSNAPYPGMAAQGLLPTPANDPRQPNPFYDFPSRLPASQYYYPAQQGIMFPPPTSSSLLSPQLPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWS9</accession>
    <name>A0AA38KWS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_397622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="MU793636">
        <property type="protein sequence ID" value="KAJ3780878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWS9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="379" mass="41376" checksum="04C849BE5A411BA2" modified="2024-01-24" version="1">MATSDFAKANIDEIVENLTTDEDVSLIAGVGFWHTHAVERLGVPAIKVSDGPNGIRGNHFFMGTPVKCLPSATALGATFDPKLIESVGLELLAREAKLRGDAVALAPTCNIQRSPLGGRSFESFSEDPRLSGMIAAAYVKGVQSGGIATTIKHFVGNDKENDRMAYDSIMSDRALREVYLMPFMLAQKYAQPWSFMTAYNPVNRTHVSENPLIIQKILREEWKFDGMVMSDCSGVYSIDHSINAGLDLDMPRTNKWRALDLVKRSIGSRKITPRAVKPELGNASKNAPRLVLDGDGEERTVETDEDKALIRKVAAESIVLLKNEGELLPLRPKEQGNPAVQLGGDTVEDFDKLMDQAVAVAHEADALISVVGLNADWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWT6</accession>
    <name>A0AA38KWT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_386588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWT6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="376" mass="40294" checksum="71CDD58304E8401E" modified="2024-01-24" version="1">MSSRKTTVLVLGGGSGGVVVARSLSKSLDPQKHNLILINKLPYRIILPASLRMLVSGEGKLEERILVPYDKVFINGNGTFIEGLVTQVNAGDKPNSGSLTLSDGRVIEYDVLVLATGSKWDGPTSFPDDAKSVNSHIAARRDEIAKANNILLVGGGAVGIELAGEIKDSWPDKAVTILNRGARLLNDTYSSKLRLGLQRQLEERGIKVIVDDYVEDLPAKSSGPVQVRTAKGKSLEADLILRTWGARSNTTYLPSSFLTPNGTVKVLPTLQLPSHPNIFAVGDLIEWDEQKTAAKAQMGHAPVVAKNVELYLQGADLSKVGKIYKGSMEMIMVSNGRKTGMGWMGAMGGVLFGPFLTSRIKSKDLMIGMARGASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWW5</accession>
    <name>A0AA38KWW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793606">
        <property type="protein sequence ID" value="KAJ3781088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWW5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="476" mass="52132" checksum="7DD13D7D215AF354" modified="2024-01-24" version="1">MSRQNSQSGSYNPAYTTYPSTYNNGRNMMRNQPPTSSAPPTQYERHNRGLQQTHVYGKENSPSTCCHQAELERAQMLQMGPAVLQNSMASNVDHGEQHTATRKTSGSVLRHPTAPDFVPVSHSDDTSAPVAQRFTVPVLSYQSNRTIQDHGIFGAQTSHESSSVIFSPRQQMGVNGAPITGNTRRPAPDIHVGANANRDMVDHLNNTHTRSFHVSQLSPNVRAGNSRANATLQLLSPSYFPTPCPPPSPEIQYSVSPQNNLPSIYPGTSSQLSFPPGVIPATDIRAQSGVSQSTSRLSTVNENSAEHPSRIVTQSNRSFNSATVGVKLDAYSSHDKSDTDKTPTQKSATCHYASSSHSHEREGSITPVQASNKGFTIVPHGINGPAPQSEINQGSVDTRRGNAVPQTVPQHRHGKEQLSSSQRRTVDCKITPRDIDKLDHQRPVRRNSVAYSRTSETKDGRPYPFDSFPTFHSFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXH1</accession>
    <name>A0AA38KXH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_373805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="82"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="555" mass="61546" checksum="0E096DFFE2125F99" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXH4</accession>
    <name>A0AA38KXH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_429674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="MU793504">
        <property type="protein sequence ID" value="KAJ3782033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041339228" description="pectinesterase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="38"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="337" mass="35738" checksum="08EE455C269363A3" modified="2024-01-24" version="1">MHYFVKSVISLATSFPLALAATRTSPPVGAVVVRAGTTTQGEFATITEALDSFPDSTSSQSLFIYPGTYTEQIDITRSGTLTVYGYTTDTTTYLSNTAIISFNSPANTAGSDDASGTLRIHKDNFSMYNVDVKNTFGPGVQAIALSQYGSQVGFYACAFYGYQDTLYANEGTQVYLKGYIEGGIDFIFGREGSAYFGGNTIGVLAEGGSITASGRETDDSGSYVFHQNTIVLGSGASSSVAGTYYFGRPWSDFAKVIFESTTLSVAPNPALWSLWDGEADSIDNVLNADYNTTGSGAAKLARASWAVELTATDAAGYSISSAVGSDWEDWVDVSYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYQ3</accession>
    <name>A0AA38KYQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_39659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793394">
        <property type="protein sequence ID" value="KAJ3784013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="171" mass="18826" checksum="DA1F74A9679E6490" modified="2024-01-24" version="1">MGSPGDSTTIAVPKVGVGVFVLNQEGQFLLGKRTGSHGHGTWALPGGHLEARESFEDCAAREVSEETNLKIQNIRFLAATNDVMVAEGKHYVTIWVACEMVDAQAAPENLEPEKCEEWEWVTWVKIKRWAKAHQPEEGKSTDTGPRTLFLPLLNLIAQRSRFEGPGPGFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZX8</accession>
    <name>A0AA38KZX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_310625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SQRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZX8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="444" mass="48675" checksum="003696B37C3FFC29" modified="2024-01-24" version="1">MLVNRRLAAKSAHLAHYSRYSSTYATSAKYKIVVVGAGSGGLSVANQIYDRFAAAGKSLNPGDIAIVDAAEYHYYQPGWTLVGSGLRSKSTTRQPLTSLIPKRLAHIPENVKTFSPEASSLTTTSGRTLSYDALVVAAGLQINWSGIQGLPQALVDSSSGVSSIYSYDTCDNVWNDIESLRNGNALFTQPAGVVKCAGAPQKIMWMALDRFKRTSRADKIKVDFYTGMPTMFSVKKYSDVLDRLRQERGVGGYFQHNLISIDSKNHKATFKKADGSIADVDYTTLHVTPPMGPLDFLKGSPIVDSAGWVSIDPGTLQHTKPEYSNIFALGDCSSAPTSKTATAVIAQAPVLTENLFSVMETGKVSSAKYDGYTSCPLLTGYGELLLAEFKYGLEPEETFPWMDQSKPNRFFYHLKKDLFPAAYWNLMVKGKWYGNKTIFRPSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L067</accession>
    <name>A0AA38L067_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_349207</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L067"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3787298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="543" mass="61210" checksum="92211BA4311DF375" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L070</accession>
    <name>A0AA38L070_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sc15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_416517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L070"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041214636" description="Sc15 protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="19418" checksum="07224C2D302C10F8" modified="2024-01-24" version="1">MFFARFFAVFFLFASFGIVTSVPSNAAVQKRQDTADIETILNTLKSSTDSILPQITSVGQSGNASDTTVTPLINELKATLNTATSSLTALQTSSRKARRQSDDDIATLVAEILTDIADSLSTLLDDAAAIPDLGSLLTGVDAALDEVLKGLEILLAGVLTLVADLLVDVAGLLSSLAFGLTLASLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1F0</accession>
    <name>A0AA38L1F0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trs120/TRAPPC9 TPR region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_230519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794927">
        <property type="protein sequence ID" value="KAJ3779437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1F0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="2">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="107" mass="12033" checksum="040085BFCF698E3E" modified="2024-01-24" version="1" fragment="single">DVYREPFGWPELQIGVVRESVAVAEALPDFLAVAQYALSSLKTLQEFLEAGDQYHLYSTAARAMQIARRRGIMKAVEYWSGRPVPRSSDSNAILKGGTDPFLYNPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L277</accession>
    <name>A0AA38L277_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_240379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794447">
        <property type="protein sequence ID" value="KAJ3779650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L277"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104:SF2">
        <property type="entry name" value="CXC3 LIKE CYSTEINE CLUSTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104">
        <property type="entry name" value="SI:DKEY-29D5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="1">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="592" mass="67095" checksum="1B3CB894918A871D" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2K6</accession>
    <name>A0AA38L2K6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase activating protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_87539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793500">
        <property type="protein sequence ID" value="KAJ3782092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1845"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="1935"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1760"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2132"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1125"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1760"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2132"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2162"/>
            <end position="2171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2187" mass="242079" checksum="28C5AA2AF5571B85" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2R5</accession>
    <name>A0AA38L2R5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_231119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793735">
        <property type="protein sequence ID" value="KAJ3780445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2R5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6799" checksum="228DFB96024FB4F6" modified="2024-01-24" version="1" fragment="single">IDVIDSYFNEVLNAIVGKFYKKWVPFPQNKVPAPIRDEPKFFPYFKDAIGAIDGSHFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2X8</accession>
    <name>A0AA38L2X8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_318170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793460">
        <property type="protein sequence ID" value="KAJ3782677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2X8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="871"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="894" mass="100901" checksum="64EEF92E542DDD6A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L349</accession>
    <name>A0AA38L349_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_367825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793606">
        <property type="protein sequence ID" value="KAJ3781090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L349"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="262" mass="29638" checksum="E060E814080D040C" modified="2024-01-24" version="1">MARGPKKHLKRLAAPSSWMLDKLSGTYAPRPSPGPHKLRESLPLTVFLRNRLKYALTGREVTSIVMQRLIKIDGKVRTDPTYPAGFMDVISIEKSGEHFRLLYDVKGRFAIHRITPEEATYKLLKVKKVAIGARGVPHVVTHDGRTIRYPDPLIKTNDTIKFDIEQGKITDFVKFDTGNLVMITGGRNMGRAGVIVHREKHIGDWDIVHVKDSLDRTFATRISNIFVIGEGNKPWISLPKGKGTKLTISEERDLRRKRAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L386</accession>
    <name>A0AA38L386_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_317230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793431">
        <property type="protein sequence ID" value="KAJ3783202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L386"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="299" mass="32483" checksum="FDB9BAB50ED6926A" modified="2024-01-24" version="1">MPLGPPSSAIHIQPAVSPHMQNAPRTPTSITIHPVALFSILDHYLRRKDDQDRVIGTLLGTRTDTHVEVRTSFAVLHSETSEQVAVDMDYHRAMYELHHKVNPKEVIVGWYSTGSNLNTYSALIQNFYSQETAPHQAIHVSLDTGVEPGQPAGVKGYVSSPVGVFPKPENCVFVPVPVELRFRDSERSGVDLLTSTALSSSSTSSQPLSDLTILESSIQNVISMIDRVLTYVRAVLAGEAKGDAAIGRYLMDTLGASTDDLEKGGFNGRLQDTLMISYLANLVRAQAEVSSRLALVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3E6</accession>
    <name>A0AA38L3E6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_52773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793419">
        <property type="protein sequence ID" value="KAJ3783457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3E6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="310" mass="35129" checksum="75F2898488B79826" modified="2024-01-24" version="1">MSTEESQFLALYEANLIPLRVCLVGLTWGLHDYFVTIEDEVHYIWAQNFNFSKFMFLWIRYYTLALLLFDVVQIHVFALPGVTSDNICVAMDSIIRVVGAISLWAVEIIMQLRVYALYHCSRKIAFFNSVLFLGSIAGYMFVLVHNAQRRRAVIASAITLPLPGCPSIHTGIEWAQWVPATIYEGILFGFALYKTIQSNASQLRKGNRISLRSILLRDNLVYFFGIACILVFNNLMVVVITHIPWFSYGPFHAAVGILTTRMMLNVQKAAGRTAFISGLEEEEFPEERSRPPLAVGESWNVARNTQLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3I0</accession>
    <name>A0AA38L3I0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_316486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793411">
        <property type="protein sequence ID" value="KAJ3783622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3I0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="9"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="37640" checksum="749BC9B7C7A6E7B6" modified="2024-01-24" version="1">MSKEVKAWGATSPEKTEPITITRRAPDDQDVGIDIKFAGICHSDIHTVRSEWGKTTYPLVVGHEIAGIVSAVGKNVTKFKIGDHVGVGCMVNSCRQCENCHDGEEQYCFSGTVFTYNSKDPKDGTITQGGYSQHVVVDQAFVLKVPESIPLDKAAPLMCAGITLYSPLNHWNAGPGKRVGIIGFGGLGHMGVKLAKALGSEVTVFSQTNSKKELGLRLGADDYVATSDPDVFSKLSRKFDLIINTVSASIPLEMYLSCLRRDGSLVQVGAPEKPLLISPFSLDAQRVGLHGSMIGGIAETQKMLDLCGEKLIFPEIEIIPASYIDEAYERVLKSQVKFRFVIDISTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3V0</accession>
    <name>A0AA38L3V0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_271780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793382">
        <property type="protein sequence ID" value="KAJ3784297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3V0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="10">
        <location>
            <begin position="222"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="892"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="981" mass="106690" checksum="B0A40569AA16C4B6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3W7</accession>
    <name>A0AA38L3W7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_271642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793379">
        <property type="protein sequence ID" value="KAJ3784372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3W7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052346">
        <property type="entry name" value="O-mannosyl-transferase_TMTC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22097" checksum="816D4E305E109E0C" modified="2024-01-24" version="1" fragment="single">YASSTTPHSTASDPAEIEAMNCLEQGTRLLEEGDVEGAKRLYARSAEINRNASSLYNLGVTYYHLKDFDAAIASWQESIALQPSSPDAHTNLANAYILSPLPRPDLALHHLRIASSLAPEDPEIAFNLAAVLEATENLEESLEYYKKCEAYGIERAKMHIRNVSSISISCFLWLVSPTTQVTAKLLARRVQSVQSSGQSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L472</accession>
    <name>A0AA38L472_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_270413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L472"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="81" mass="9162" checksum="F249C1CE51E2852B" modified="2024-01-24" version="1">MEKTTGCGQTQSIQKQKIFVIPLVKHCVLLDPNEAIPLRDLQSNKVPFVESLLGMLDKSQEGRSHMFVPMFNAYKFPLTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4X4</accession>
    <name>A0AA38L4X4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_267473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793318">
        <property type="protein sequence ID" value="KAJ3786277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4X4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="198"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="476" mass="55262" checksum="39D55F2EDCE7E770" modified="2024-01-24" version="1">MDDVLATSVQGFTLNNKTESPRRHFGKSSNLVLMRTAVDIKKEVMGDQPMQVVDRRPEFWTVYPWQRQILRLDQQRPLRFPPDDLLWSLIDLYFVHVHPYLPLLHRPTFITALSDHLHIQDYGFGSVVLCVCAIASQFSKDPRNYVEGVNTENSLGWTWYQQVSQVQAVDVEPPTLYQLQHCCLSALYLKGTSMFHSTWGVIGLGIRFAQEMGVHRKQKGQARTVQTELWRRAFWVLLGFDVLVSINFGRPRATTDDDFDLEPPIECDDDYWENEDPSRAFIQPSGVPSTMSFFICYSKLLEIAGLGHRMLFSARKLQIWKKVVPSGPHWDHKVVTELNSALNQWMSCIPEHLKWDPNREDGLFHRQSCILYCFYYWTQIQIHKQFIPRSNETSMLKFPSLAICANAGRSVVRILEVIERIDFEILPNFTSPVYVAAIVLLMSIWRNKYSIVPQDTSKDMDDVRHSLKATARYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5M6</accession>
    <name>A0AA38L5M6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_385648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the VPS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5M6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="741"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="969"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1057" mass="117097" checksum="BF772CC051C80B2A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5U5</accession>
    <name>A0AA38L5U5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEMO1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_127227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5U5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="328" mass="36296" checksum="7CABFCD1B88E1406" modified="2024-01-24" version="1">MFRREKRQDVRSASHAGSWYTDDGDELANELSGWLNKVQGTDPPYPIAGCKAVIAPHAGYSYSGPAAAWAYKSIDTVGIQRVFILGPSHHLYLNGCALSGCKEYATPVGNLPLDLKTISELRDTGKFESLDIDDDEAEHSLEMHLPYVRTIFKGMDISIVPIMVGAISQQSESAYGQLLAPYLAREDTFCVVSSDFCHWGTRFSYTYYYPEPEPSNEPGIRLSRTVPPSDAHPIHESIGRLDHEAMEILALPSSSASSVHVDFAKYLSRTKNTICGRHPIGVLLGALTALEESEDVHPTIKWVRYEQSSACETIRDSSVSYASAWIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L659</accession>
    <name>A0AA38L659_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_95198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L659"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="236" mass="26036" checksum="0487FCA8001A30A8" modified="2024-01-24" version="1">MERQLPLCLSLLPPLLYLERLLSLLQVLPLFWSNKAAVAGTFTAVAVVALATLAGVILCIRKRRRESHSRDRSMSEKFASMDFDNARPYSTPSEPASHDLSHEPMNAYANRDPAFYPTHDPFVANAHNMPYAGSASLPEITYSYAQDVNNQYPYYGNETNNVVPPSAGTRSTPALLTQDFHNPFEPQDSTPPRAAAVSKIPRVSPNPFSDPTFRGSPAYQPSVDSFYGAPVDESPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6K9</accession>
    <name>A0AA38L6K9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_308462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6K9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="402" mass="44413" checksum="6685CED96A58EF67" modified="2024-01-24" version="1">MKRRFSGSSENTRKQQKRILIGQCDSALLKDIAGHSLQNYDISTLTSLFDFSNQETAASIQIRFDEIARHILHHLSLVIRSSSGILGTFEVLELEFYLWKSVVHEDPFTHGSAEQAKSGNWQVATYFHRAPQKSNKPENSPTVVTGGYRGGTRKGLDITIGPSATIPSPYFSALPTGDANSSTRGGILLRTLRETSTGRVISGPSLVVDEILKLSCPNSISDLVDKQWKGNISAFRGNEQSSPGEHTLHFMLKHEVEIQAVYLYKSPRIGLGLSHPSVSPSFADPRVVFLSKPYRYFIHPELLTSNGRPQTFIGILNSLQAMCSSDSLHGLDERETKEITGNICNKCGLKAHTVTKYLEYYLGKLDDRSDLESFIGASSKDSPSAYLRLMGILSTKSRGDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L770</accession>
    <name>A0AA38L770_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L770"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="920" mass="97753" checksum="B397DB6474311FF1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC32</accession>
    <name>A0AA38NC32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_72496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793453">
        <property type="protein sequence ID" value="KAJ3782791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC32"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="130" mass="14515" checksum="48C849CC4B02A271" modified="2024-01-24" version="1">MASVKLEVESVEEDASDGGRIVCNVFCSPSAYPHLTSGALDDLQYHLTTVLHQTLSHPSLHPKNLSIIPRKKSWLLNLDLLVTADAGNIYDALFMAARSLVGYQSPKNQKRGIQKPKKSFVCFGRYGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCA2</accession>
    <name>A0AA38NCA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_361380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793427">
        <property type="protein sequence ID" value="KAJ3783286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCA2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="319" mass="34910" checksum="BE812E2E48072D39" modified="2024-01-24" version="1">MQRRDIPPLTISSRRRQFGGLASQSREILIVTDTRDTVQGMGSHNPVSPRNSSTPNLPLNIGLHTMDTVPVLPTSPLSETIPRPNLIPRKTSPPNFLTLNSSPLSPPTPFSPLFTMPMTPPPSPLKSSSRPPSRESTKSLPVPIHTHTPPNFPRVFHRNSSPAVHTGIWQNTNAYGEAPQFSRHNMGSDVVMPIPARSRQAKPITIVEPILVVRSPSPVASTSSSKTDFLAPPPFRRNAHSRKRSNSTSAVLDQKSEFKEPVVHDLPISEFTSNTPHSGLGSLRARTKSVISRSKHFVHSRAQAISNVDSILGPTVQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCY2</accession>
    <name>A0AA38NCY2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_196933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793342">
        <property type="protein sequence ID" value="KAJ3785431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCY2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="92" mass="10598" checksum="B247AC16B9540594" modified="2024-01-24" version="1" fragment="single">GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEAAEAYLVSLFEDTNLAAIHAKRVTIQPKDLALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH60</accession>
    <name>A0AA38NH60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794319">
        <property type="protein sequence ID" value="KAJ3779717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21819" checksum="2BBC5F7FD309397C" modified="2024-01-24" version="1" fragment="single">MLSLELPDFQHAIAQTPVHPSDLGSFFAATASRNTSENPTRRLPEFHQRKTSVVCTSNYLFGDEEVTFEYIAHTNAFETFPLSLEELQSREGHKFGTKDRDDSSFWAELRDFFSNGRYPARLLTDKERLRFKKRSRRFFLQDRRLWLAPRTNSDRLPQLVIEEAGKRQELLATAHNEIGHRGRDAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHK2</accession>
    <name>A0AA38NHK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_413387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793617">
        <property type="protein sequence ID" value="KAJ3780992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHK2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="468" mass="52349" checksum="4219B49DD4A60A1B" modified="2024-01-24" version="1">MSVYSFCSTDGKTYKRNLHGFEALCNSYALHDFLLSFTGSAEVQLSDASGTPASDEKVISCLRAAWILLRYRVPGVALRTTYQPKDTSWTVFYDVPLSSEDIDTWVSQTLFWRETRPGCLVHELDEKWEFTHGEYPLRLIASPIYESATVDLKAIKWGEEIARLASTGAVLTGLDMNSSAEPAAQKKELVPFLPPFVENKDRTHDVTMRLVVFDDARTLALRQKCRENHTTVTIAVDAIFACAQAEAVLASAATVGGAHYTSTVEAYNKALHWFMPLSCKDQRPSWPTSSSIDHPEGTTLFGTDGFALQANIDIIRNALGFSVDAKSFNRCDKEFFWSSVIKEIAAAHEIPKKDLAGYVQREREKQGMCKTFHPSSMMVKLPISSSIGDFDHLGLFGRYLPSSTSPTKVHRVLFRARPLTPTITNIFYQYDGRLNCSLLAAAQWYSPPEMDEMETALRNWFDLVIGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NII6</accession>
    <name>A0AA38NII6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_272431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NII6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="89"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="498" mass="55043" checksum="49C318F522B824D2" modified="2024-01-24" version="1">MSNTQSIAPVPIDQIVKATSILHQRTIPPKFGHDLLPYFSFKRGYLNLNNGSYGALPKVVTEACNELMAWQEENTDFYYRIGFIPPLIGVREQLAKLVGASDVDELVMVANASTGLGVVLRNFLWESGDVIIRCNTTYATVYKTIQYIHDVTPGVQISEFQLAFPTTYQAILDGWKKHIDNVKQNAPPGKKIVAVIDSIVANPAAAMPWKEMVKICKDAKIWTIVDGAHSVGQEELKLADCGADFFVSNCHKWLNSKRGAAFLWMPKESQKIMLTTIPTSASYVTPGPDRPDTNIVSQFQYNGTIDYTTYLSVHVALQWREWIGGEAAIHAYCNNLAKAGGKLIAQTMNTQVMDPNGEFTKAMVNVTLPFPSDFQAQYDASVGTALSNKLLAQNMYAVTYYHNNIWWTRVSAQIWNELDDFKILGNALVTICSEIVTEHKNANVPGNCKAASFESYLQQPIKGAVALDLDNALGAPKPVTTTKVVPVGYHTQLASIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIU9</accession>
    <name>A0AA38NIU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_430340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793757">
        <property type="protein sequence ID" value="KAJ3780393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIU9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="68"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="516" mass="57352" checksum="2CEED9FC4DD1FB07" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIZ1</accession>
    <name>A0AA38NIZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_280144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="MU794054">
        <property type="protein sequence ID" value="KAJ3779929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3779929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="154" mass="17096" checksum="BADF2F3C830CC323" modified="2024-01-24" version="1">MNRLFAQTPRLSQKIFFSPILEGSYGRCIKPYLNLLPATGNHVYGEFMPPMLGFIQLDTNSVFLDLGSGIGTAVAQAAFACQCFSYGIDIWEPIAKLGDKMIHDIQVKCGLWRVSFGKMELELGDMCKSPRVIQLMGLADLVLINNKVFNAICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ25</accession>
    <name>A0AA38NJ25_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_356387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ25"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="288" mass="31029" checksum="E59F712FA9003342" modified="2024-01-24" version="1">MASLQGDVAFVTGAASGFGLALTKELVSKGAKVIMIDINDCEREVSKLNSKAGKIVAIAQRADTTSWEQQYAAYEAGKKIFGRIDYFFANAGIAEHPWLPNFNPSTARDRSIIKPDIVTLSINLIGQLYTAALALQVFERQTQNRHGFKGKLLMTASVYGFFPSAIMAMYASSKAAIVNYTRSTALIYAGKGITVNAIAPSMAPTNIIGTPEVAAGFLKAFDEKDLCPVEFVVEQFMSLLGSNPDSGRVIAISGKEAWDQPVDSHKYDACKSAIDTIDTQLTQAFGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJC9</accession>
    <name>A0AA38NJC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793693">
        <property type="protein sequence ID" value="KAJ3780589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJC9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041451691" description="Transposase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="101331" checksum="0457EC9A51E360DA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJU8</accession>
    <name>A0AA38NJU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_352385</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="357"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3786242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="771" mass="83648" checksum="599377D468777146" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKJ2</accession>
    <name>A0AA38NKJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_76254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793463">
        <property type="protein sequence ID" value="KAJ3782629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041305470" evidence="11">
        <location>
            <begin position="20"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="12">
        <location>
            <begin position="470"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="767"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="789"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3782629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="864" mass="94196" checksum="8581945FB8382F47" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLN0</accession>
    <name>A0AA38NLN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_388259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="189"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="422"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="866"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="933" mass="103113" checksum="D4B77454A545EAD6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLT1</accession>
    <name>A0AA38NLT1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_395523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793361">
        <property type="protein sequence ID" value="KAJ3784849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLT1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="23450" checksum="AC3ADC5BD21E56C7" modified="2024-01-24" version="1">MDEVYMDKNVAPGIKSLIEKVKANPVHLGNVTCFMVDVTKRKYAAQAQPPASPISTTINEAEMLYSELSNDPTALTVITPELISQYERNFYYHGVSGNPPKLLWRSDLETNPFPIPAPGTNFYKIPTKTASYSALETARFLTVEEGGHESFGPIIVWIAVRPNTPNAEAVRDATPDILRILANVQITDAVVEWYEGSVVSLSGPALKVNGESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLU1</accession>
    <name>A0AA38NLU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_333527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="383" mass="43010" checksum="9D8B7F9B2567C435" modified="2024-01-24" version="1">MAADSMFVFDANPHAPSIINSEEEALVRTLFANFDTAWNHPALQTRLIRAWHQPRRQSILNGMTLFGAIWSASKLPNFRSYKVVWDAMRVHLENDGVLAALVSKFNAYVARIGRKTTDSRLVQLQTHLEAPQAPGSFTSIPREDAGHHQTKRRKSLGEIFHKSDKLSPTYSLQEPTPPAHRNREEVYYSQSPSSHLSTCSIYSENYANEARTCNEGSSYPQDSEFHHHPFLYSGSSGSGVRTQTDIYHESFPGGSKPGPFVPVFPDTTSYLGLTYGMGHGKEQLSEPDATETRQTPANIGIASNPSNLAFHDYFRFPELNSYVDRRQAHQSNTMHLPCSTASYNLPFSRSQDACWGGCVERGSECDRYNGLQNGRNTRECKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMJ5</accession>
    <name>A0AA38NMJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_309890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3787008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMJ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF56">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="176"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="321" mass="35046" checksum="572CF59466475517" modified="2024-01-24" version="1">MTDSTSPFADFQDSPIVAQAKKEVVVNQYSYTERDVILYNLGIGATETQLQWTYEGDEDFSALPTFGVIPQFSASSSLSLDWLPDFDLTKLLHGEQYLSIKAPIPTNGDLVNSARILEVLDKGNAAAVTIVVETREKHSEEVIFENQSTVFVRGSGGFGGRRTGNDRGPASAPNALPERAPDAIIEEKTHTSQAALYRLNGDINPLHILPEFAAIGGFDKPILHGLCSMGIAGKHVLQAFGLFQDIKVRFSGIVYPGETLVTEMWKEGSKVVFSEYMRIDPLISFSWYPLEKVTKVQERDTVVLSSAGASLTKKAATGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMT8</accession>
    <name>A0AA38NMT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_152268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22796" checksum="67F31018ACDA4C17" modified="2024-01-24" version="1">MSGEEPEVIDLTGPDENDSEQDDQEDSSDQDEEEDSGQSSDHSDDSVEVQINSDTRSKLYLSLAALPETQVRSILNQLIEQVPAVEYALTRELVTLKRKLDHHDYERHLERCKNCYEEFDTQLKKRNNECSFHPGSLEPDYASFPDWDEDVHGPIDNEETRRHYPENFIWSCCQADGNSEGCVHGVHQSANAQKKARVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN20</accession>
    <name>A0AA38NN20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_127570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="304"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="406" mass="44994" checksum="E9561AA79F01EB2C" modified="2024-01-24" version="1">MSNSLLPQSPSIRRASTRRRAGSNLPPLQDIHHGALQAIRTFLKGRICYDAFPISFRLIVLDTKLSVKRALQCLLMNSVVSAPLWNSDKSEFAGMLTVLDIIHLIQYYWRTASYDFATEDVETLRLEKLREIEIELGVAQPPLLRKHPDNTLYEAAQVLVQTHARRLPLLDYDSDTGHEVIVSTLTQYRLLKFISINCPQEIQKLNLSLRRLKIGTYVAASSPTDVPEGQNPYHPIATATLNTTVFNVVHMFSELSISAVPIINEDGIVVNLYETVDVMTLVRSGSYQSLDLTISEALKQRSLDFPGVVICTASDSLGTLLQLIKKRRVHRLVVVEGEEEEKKGGRKGRLLGIITLSDVLRYIMGAGTITETQEPRQTQMPSASSATIPSPSAFGSPTIPAAPPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN35</accession>
    <name>A0AA38NN35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793890">
        <property type="protein sequence ID" value="KAJ3780140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN35"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="60" mass="6641" checksum="66EE0C257E8EEF24" modified="2024-01-24" version="1">MCNWNGNKRLEFSSGIHKGLEVCANWQRPNGCTEENHPKKHRCSGCASSNHGAEECPDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN57</accession>
    <name>A0AA38NN57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_347853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN57"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="208" mass="23120" checksum="4243F5E14C523509" modified="2024-01-24" version="1">MVKSEPNGAESFVKKEESGFRIKPEFQENAACSTTDRGNTLSSASTDEPNEQPSQPSHLQPQPEIQIHVLDLKTLFHSSTGSQIGAESVQAMARELQLDSGGVLLSGMLLEKEFSSGWDAALMLSIFQTFIDGRTVDEQRATAASRRDVAKEEEIILQKQREAERIQNQSIQPGLDDDVDPNDFRGQSEEEQNTNWLGDEWSDYGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNL0</accession>
    <name>A0AA38NNL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_82303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNL0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="206"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="210"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="430" mass="49225" checksum="9EB99D0118BCE3D3" modified="2024-01-24" version="1">MKDLSSASTSSRHARNSLIYPKKRPSPHGVSKSHKSPLLSQNVMRKSPRSAKAALIVQRQQLRRDGVILEDEYREDIRCYMHEMENYTMSSTQSMDQQPEIRWHMRPCLVDFLVEIHFSFRLRPETLYLTLNIVDRYVSRRIVFIKHYQLVGCAALWIAAKFEDAKDRVPTVQDLVQMCHDAYEESAFIQMEGHVLSTIQWTLGHPTAEAWLRLMCCGPCMEEPKVQHVARFLMEITLFYREFVKYAPSSIALAALTLARFLCGKPARVWEETDECLEIVDLLDTRLAKHVNDLSETLVKKYSYAFYSKAATFVVQYYLQGGKFIRITTPALPVTPTRSVTMSAVSTPMSCSTSISDGSDDFPLTPVTPALHPPSSDYDDKENRPTTFEPVYNKHRIDSPPEQFLPHDFVTFSRPALHSLNVSSSPRAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNS8</accession>
    <name>A0AA38NNS8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_372602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3789004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNS8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11854">
        <property type="entry name" value="SH3_Fus1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035521">
        <property type="entry name" value="Fus1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="274"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="354" mass="39337" checksum="023C83EF430C4C48" modified="2024-01-24" version="1">MSHGHLRRRSSAFREIKRSPQATVTDTSSVSVTTPTATDSSNAYAQQIVNSVPHSTIALAVVLSVFAAILLGVCAWKYSNRRRRRRNQAVDSEDALYRPASNTSFNSEKQSGLEKPKQAFIPIPHTGEAAWTPQVRTYLGVPLKNGELPNHVKAAREGRAWRKSPSPPPSYEEKVDPFRADAPKATKAPQQKQLNVVTNNQYPTSHISNPTPFLTTVTEENSEPLPSPLRTTSFAHQHKHSRSRSVSSKHLSGEIITKITPAQARRSRGGSISEKIRLMYVISTFHPSLDDELSIRIGDCVRLIEEYHDGWCLIQHVGSTDAPRGVVPRFCLVDRQSAPVKSRKRSLTQSTVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNV1</accession>
    <name>A0AA38NNV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_411423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793545">
        <property type="protein sequence ID" value="KAJ3781565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="118" mass="13420" checksum="B4EA0BC4FB801D6A" modified="2024-01-24" version="1">MRVANDASMEPVISVDKISQQRWKLKCSICDIPLIRNRSDTYSAFIFLPFASPALPLGSSQRLSIHFSPHLHIHNQEDADRFSHFEVQQWLITNNPTILTIPNNSRTPTGTTIPPRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP01</accession>
    <name>A0AA38NP01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_364119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793484">
        <property type="protein sequence ID" value="KAJ3782315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP01"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="217" mass="24946" checksum="CD49DA359F06245D" modified="2024-01-24" version="1">MTHDVPAVLGKPSLNIYRENGIVYLNAFLETNLEIRRIGTKQTNILIYFLLFRNTSMSSMSLPSISEMFPIHLITIPPRRRLELMAGSNSKSRHTQHSANNDRNSGSLPHLYSFVSTSNHAVSSDDDELDGENERHDQTKKHVCPECFKRFSRPSSLRIHGNTHSGLTPFSCPYPGCGRRFNVSSNMRRHYRKHKFQPPGNDLRKLRPSYPPWPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP05</accession>
    <name>A0AA38NP05_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_378659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793480">
        <property type="protein sequence ID" value="KAJ3782375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP05"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="128" mass="13286" checksum="10521D4247A83197" modified="2024-01-24" version="1">MKGDVESVSGTTLFLWSTGAFSVARTEHVGATVIEYSHSDALPIGPVFVIDCDLVSSTAACTELMWFTGQSGTRATSSVTPFGTFGVSVSTTATRTSSSKNTAGPLKPFGSLAGACVVVVLSLFQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP24</accession>
    <name>A0AA38NP24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_407393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793461">
        <property type="protein sequence ID" value="KAJ3782660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="356" mass="40055" checksum="F522918ADA78D3AB" modified="2024-01-24" version="1">MDSLANPSANPPFPEDVPTHPLEVINYKLLLGKDQAEIQKFWTACKTLGFFYLSEHEIQANDVFEIGRQSLRNLPLEEKLNFLHNANAGDSFGYKPPGANLTNASGGVDTVEWWNIAKDDVLFYPQIAYRTYAAPINDAMDKLKDFVDKSESVSRTLLQILNEMLRLPKGFLDSCHIASKPSTSEVTLIRNPGREKATSFSEEQLAIGAHTDFGSISLLHNVLGGLQVLPPTTKEWIYIKPIDGHIICNLGDALSVFSGGLLRSNLHRVIPQPGAQIHWDRWTLVYFFRPHGTCEMRPLIESEVIKSAAEESTNSFPHGISAVEWFQRRTKYFHKDEETSAAESWKQARGTEHSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPP6</accession>
    <name>A0AA38NPP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_353084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3785990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30944" checksum="E092AC70E11F4093" modified="2024-01-24" version="1">MEAIHYWWAHVRDQIEKQKPEIRDRLNYPAILLVHPGSHLSVAVAAFTDVMNVETLATIPLHVHSTNVSEVLAGERFIYALRTTLQRLHDFYGAANNLPPRQVEYPFRNYIVQNEAKLAFEYIRQVPDKRVFHASLEDGTPLFIKFSRRYGEVTHHAAHDVGLAPRLLSVENVHGWYVVAMEDLSKDYITLAEISDDSYLSLLPEVHEAVCKLHARGHVHGDIRPVNILVKKPDVETAKPRIVFVDWDWSGESGKVCYPHSMNPGYGIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQA6</accession>
    <name>A0AA38NQA6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_285046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1439" mass="158130" checksum="3D4D6469506650A0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQI2</accession>
    <name>A0AA38NQI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_305476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQI2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="117" mass="12752" checksum="E7077FBD6E41AD0D" modified="2024-01-24" version="1">MPIHIADPTTTPESLAKASEEYLIFYSSIVNGEMWCPDCLAVEDLVKNTFSSEDAPSALIIYTGDRPTWKSPSNVFRSGPFGVQCVPSIVKIQNGKEVTRLVDQGEIIPGLGHLVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQX9</accession>
    <name>A0AA38NQX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_260515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="215" mass="23551" checksum="A7F1AA04B1C4F922" modified="2024-01-24" version="1">MFAEHLNNLFPELKFPLELARRILTHASHPAAIYGHNAGLSFMGRRVISAYLYLLLSSSPNLKPSDDLEAIVAQTLNTYVLGEHIGSKWGLGRVMRWTPTLKTDKAKDANFTLLKGVGLYKVQGDAVSAVMGGIFEQFGGSTAHRVFHTRVLPYILARKNNAGLPEAFHADVHSACNRFGGLQGPLNVDRPPAMATKTMGKDITEKVEITEIPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQY2</accession>
    <name>A0AA38NQY2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQY2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="70"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="429" mass="49271" checksum="71065D0BABE0D6E6" modified="2024-01-24" version="1">MSLYSPLQRTALLSHSQSWDSNLSNLRSYYASSDPNTTNSEIDHQNPSQRFSNFVNEDVEMQTPLAENSYFVVPDTNILLHHLDALAAFADDIERSIRKDIEQSKHNVMIIIPSAVVDELDWQKKDNWFSRKATLWIWDKIQHKTVLKGQARNERIQDCHTNDQKILDCALYFARKRPTVLCSADRNLCIEAVAQGEGPLAVLNPLDHRNPPFSSRTLGTFLFGLQFERDFKEWSPTYTENSVIVARLNDDMDMDMDVDTDHVNANDLYQEDARNLLHNQVIDIFVALLRELVASDQRDNQKRARDGAAASIHAPSVPRSIHALKRDVKASDMTLQDLLDYVTHPPSRRPLELQKDNPSLARFLSKPYNPRTGWRKGVDWSRQDWTVALRKLKEIGKAWDQSGKDIVNILEFDLLPHVQAVFGDDDMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQZ7</accession>
    <name>A0AA38NQZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Longevity assurance proteins LAG1 LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_49836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQZ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="164"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="410" mass="48918" checksum="57DA57A5935F53D0" modified="2024-01-24" version="1">MDRRRKSLLELSNIEQDPAHHLTGPFLPQTPVGSLTPERSNSPYVRPQAVNDYLRWAVIPAVSLKVLLVPLVLYVDWQLISYIVVRFIPQGNTYFPSDLPNPFAQFFLLSYHIPSSSDDDPRYQKGWSDLLFIAYYVVFWSLIRQSLSIYMFEPIARYFGIRKEKLDRFAEQGYAMAYFGIMGAWGYRIMGQLPTWWYRTEAFWIDYPHWDMKPELKRYYLMHMAYWIQQLLVLVLGLEKPRKDYYELVAHHLVTIWLVGWSYLINLTLIGNAVYMSMDIPDAFFAFSKLLNYLRAERAKVVSFIIFICVWTYFRHILNFYILYSVWFEYDLIPESSKVWIWANGTYLSWWMKYQVFAPLFLLQLLNLFWYYLIMRVLHRAAVGSELDDVRSDDEDEGEDEDLSQSKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRD5</accession>
    <name>A0AA38NRD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_371909</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRD5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3789723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="548" mass="61862" checksum="6E535ACE889D0F73" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRP2</accession>
    <name>A0AA38NRP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_259659</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRP2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="121"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="651" mass="69859" checksum="1F921A566BC89015" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRS1</accession>
    <name>A0AA38NRS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_329641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="21405" checksum="C7546F7C6A960453" modified="2024-01-24" version="1">MVLHRCCARPFTCLLTSLLFLNVLTMMMLVVKQARKHVGSLLATQTFNSELYTDSFTRGCIRSNSSNSASFTKTYALAGASLMSSRSIGRMTAKESYHYQNIGYQEQQLISGIQAHTLSTQEPHSNVRYAGGNVGRPLTQPTSIPVHSPESFGRKHCNPDICYIWVHNFAYILSALELPFLSTVANPCVILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSN0</accession>
    <name>A0AA38NSN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_258523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="125"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="444" mass="48971" checksum="C613841D86DF0EF4" modified="2024-01-24" version="1">MNASIIANPTAKRASSVHDVNSLDPPFGSRYLVDSSLTFTQNAWDHVPPPVDQGATIAASLARQRAAVVSEEEKLKINSKPAKYWDNFYKNNEANFFKDRKWLHNEFPDLVAAAEPTAGSLKIAEFGCGAGNSIFPVLSANKNPLLELYAYDYSSHAVKLVQHNPLYNSPSCGSIHAAVWDLASDHLLPPGLVPSSVDIVILVFVLSALHPDEWASAIRNVQKVLKPGTGKVLFRDYGRYDLTQLRFKSGRMMSDNFYKRGDGTRVYFFELDELSLLFTGKRLSKEEKDIANSGADTTQMVEDEEDPGTGSTSEIPSIPSHVPTTIDEIDGSSPAATDPLNATAILLPIQQSGMLVPSDISTARIDSLSPNQGDLDIHPKLLDPLFDGTGDTNKSDGQHRMPHHPLFSTINLGIDRRLIVNRKRQLKMYRVWMQGVFQKNQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZU7</accession>
    <name>A0AA38TZU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_404114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZU7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041261310" description="ER membrane protein complex subunit 10" evidence="2">
        <location>
            <begin position="16"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24734" checksum="3BEAF60B00DE10E8" modified="2024-01-24" version="1">MLFAAAFVLLPLCAATSNVKIHHRLFAPGMPEYPFVERGVIDSSGLRPSSSSSQHWLDLENVLENLISNPKVDLGRVLYQVALEREDSDRDISSVKLCHIPLITSNSIILHIPHSAEISTPHAIDYFVAPIPDDGGCPRLGSDSVALASPFQVLSRLNTTIIHRTATLPPLPQLRTPPQLTAEGAPVQPPPEKSFIQKYWMYIFAILFALMMTGGGSEEEGASRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZU9</accession>
    <name>A0AA38TZU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_425106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZU9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="460" mass="50743" checksum="BB1509EA81F70722" modified="2024-01-24" version="1">MRLDINSSILIFGGSGTIGSSTALHLARKGYRNIRVLDVYPIPSAQSAGNDLNKIMGTSLRNPVDRQLSLEAEDAWSNDPTFSPYYHRSGRLLDCCGSSDGINDLRDTVAKLEDAGLGHTVEWLDAEAQIIQRVPQLTGSNIQGWKGIFFERGGWLTAAKAIDSVGRELIQHGVQFSFGDSGTFQSLILSDDGKTCSGAVTKDGTRYLADRVVLASGAWTPSLVELEDQCCSKAWVYAHMQLTPEEVKEYIGCPVVYNEDIGFFFEPNEDGIIKVCDEFPGFTRYKMHQPFGASKPTLVSIPRSHARHPTDTYPNASEITIRKAIAAFLPNFKDKELFNRAMCWCADTADANLLVCEHPRWKGCFVATGDSGHSFKLLPIIGKHVVELLEGTLQEDLREAWRWRPGSGDARKSTRAALAKDLADLPGWKHDSVDTEKGDSDHGVPWQAEHLGNVLEPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U076</accession>
    <name>A0AA38U076_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_340274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U076"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="21537" checksum="2B9D40DEA280E81C" modified="2024-01-24" version="1">MPFGLHNNNVNDHTSRDTAIGAGAGGLAGHEGHQGHTARDAAMGGFAGREAGHHGGGTASGTHGNRDGLMGAGAGAAVGHGHGHGVRDAAIGGAGGEMLGRHQGRNADNAYANDVYGGGHMAGAGAGAGAGAGAAAGGVPNDPSNPSKMHGKVEEIEGKVERGLGKVTGNPSLGIKGENKIISGQREQAAVGGHRQADALEAQAAAHRNHADALHPSGARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1Q6</accession>
    <name>A0AA38U1Q6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1Q6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="189" mass="20050" checksum="9829489F966137E9" modified="2024-01-24" version="1">MSTGTRIIQYISFPASDAFVNNRYQFTDGLEKLKTVDGHLGSFWGLQAAEEGGKTGYLVTIWESVEHHKKFTASDAFSAAMASLKPAAAGELTRFQFTGVRGSPIPGLQTAATEFVIVRPNAGTSGDAVTAAANKAGDSFEQKGYPVALGQSAHGDGVYIVVIGWPSVAVRVQDRSINVIRVSHVSVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U5L6</accession>
    <name>A0AA38U5L6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PIG-U-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_343054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U5L6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="497" mass="55628" checksum="0508F4382FF4DB58" modified="2024-01-24" version="1">MHWLSCRETITLCIVLRVLFALGLDFYLSPPTSYAYSVDNGDKVVEFINNGPGLLSASSPLTLYANLKESLWLYQRGIDPYGSGIGQVGVSPLYLAFSFFPTIAESGPLKTRLLSKLFGIFLWTAPDAFSAWFLVRIWKARASTSTKSSSSSITFVLPLIYLLSPYVILSSLARSTSVWENAILLGAIAWACESESEFKTKPKLNNSNSKSKSLLFLALRVHLSLDALILLPPLILLLLGSPESRLAEPGPFALYVAKHRSVKKQLEEKLPNEPAENQLRSTILRAALNVLFEFMVYWTALALISTLIVGHWRWMSTTWGTSLSLPSMTPNPGLWWYFFTEMFDHFRPFFLVVFNVHLLMYVAPICIKFQHDPLYALFILVGTLATFKSYPTLSDHGLFIAFWGIFPEVYPYLRHPFPTTLVLIHSALLQPLFAHLWLSHGTGNANFYYASTLVGACAGGMAIVDAVWAGLRIALEKHGKGELKLVEGEEREIVTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U837</accession>
    <name>A0AA38U837_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_339012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U837"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="250"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3790905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="460" mass="50402" checksum="246222F3B5757486" modified="2024-01-24" version="1">MIIPEGTQETLQVKKDEGFDHQSIISRGASPGLVRGASTSRPYQNSQAGYSGNRPPTYLEEEDHDQFYDEAYSKPQASDASLVHNAVAPAGQSKGYYQDLEYADPYAPNPNQKAEKLSPFAKFIGGNEGKYPLEQRIENKKRGIGRQTYPFLTWIISIVLIAVFIYEEVIQTKAQGTPVSFKPTVNPMLGPSGSALIYLGARFPPCMKNVSSVPPSTLLACLNDTANPSTINCPLEQVCGFNGFDNGTPNQWFRLITPIFLHAGFIHIGLNLLCQLTVSAQVEREMGSGGFFLVYFAAGIFGNVLGANFSLVGSPSTGASGAIFGTTAIAWVDLFAHWKYQYRPVRKLIFMTIEFLIGFAIGYIPYIDNFAHLGGFLLGLLVGIVFYPVISITKRHRAIMWTCRIIAMVLAVVLFVVLIRNFYTSDPYAACPGCRYLSCWPTASNNHCQGTGLSNSSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7L3</accession>
    <name>A0AA38K7L3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_301208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793837">
        <property type="protein sequence ID" value="KAJ3780234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7L3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="310" mass="35191" checksum="501E79894922CC87" modified="2024-01-24" version="1" fragment="single">MVSPKNLRSVQRIISFPITRLRNPSSVLHDSRHKNALTFYQFQVHLPKSRLEDATQSSWKPKGGWIHWAQSKASSTWAGFGQAPEGNWKLKVFRMGERLVDRIDYEELALKGVDPAMGPTIFHLDARGKGTDETDEKQKVMIRLLYPPSIQSAESSLAQLRQLIRTREPRHKKGFLTWMIIAPFTAPFMIIPIIPNLPFFFCVWRSWSHYRAYRASQYLAALIEHGHVTSAPSPGLDAIYEKYAPKPAPRLTSSSQNPTSSHNSSKSTIEDVEMLLTREAVPAIISTFSLEESAASDMYRAIEQAQVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9L4</accession>
    <name>A0AA38K9L4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribosylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_357710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793375">
        <property type="protein sequence ID" value="KAJ3784464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9L4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="220"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="374" mass="40579" checksum="3713FB73D42C1A22" modified="2024-01-24" version="1">MNFIDLTSDSEDENVGTSSKELKTIDSDDSEIEIINISSIKPSHGKSKSSTRLALKPASLHIGTGSDSEVEIEVVQMTPSKPRGRNHNVSHIRTPGPNSSGSSSSSTTKSPTLRDSTNHPGQPVSLPSTHVKSKPGPSRPKAHSDRSLKSDERLARKLQAQDQKEYQKLIKGITTKKEGIVFRTAINADGTLEDGSPAHPDDLARFEPWKKLFETTSGTQVKRFHWIVNYELEKRFQETKTLLSDSADAADDPTKELLLFHGTGTANIDSILNGGFRIGGVGSHRVVNGTMLGFGVYLAASAATSIGYAAGANRIFACRVFPGKITGDLTYAKTPPKTKDPLDEPYQTYSATFGPGIVYVVRYACLVLPCYVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAM5</accession>
    <name>A0AA38KAM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GGU10DRAFT_351537</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAM5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="21">
        <location>
            <begin position="44"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="20">
        <location>
            <begin position="164"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="22">
        <location>
            <begin position="583"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="19">
        <location>
            <begin position="1118"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="793"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="926"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ3786519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1197" mass="131044" checksum="D39D43CA564CE746" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBF5</accession>
    <name>A0AA38KBF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_337464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793926">
        <property type="protein sequence ID" value="KAJ3780088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="362" mass="40647" checksum="6BCC6B6D456BC014" modified="2024-01-24" version="1">MLWGKLFVSIVCCVMVIASLLNVVKVLPVGEYLTSGEESLRTKGVEFLSAVLGRCPPEKMNRQAGMKYINLYKDIAQRGIARVLTSFYCSKLEDSETVVPALKGLASLTKLPSSTSEDVPSILDAIFTHVKMKGLVQSVRFLVFTIIDTLMARHRQAMKDMNDEFIGRYIALVDGEKDPRNLLVAFAIDRVILIEFDIANFVEVCYAQLFPSLYFNITFCYFPITFRPPPNDPYGITTDDLRQALRKCLNATPDFGPLAIPVFLEKLTAGSPTTKRDTLESMSMCFPVYGSALARSHARKIWNSLKLEIFQLIDSITEEFALRTTQDLVKTMKGPMPSGPDSFDWWKMCKSMISFTSSRCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCK1</accession>
    <name>A0AA38KCK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_319487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793513">
        <property type="protein sequence ID" value="KAJ3781918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCK1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="241"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="241"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="737" mass="78644" checksum="ADCA66DEB23BE0FC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDW4</accession>
    <name>A0AA38KDW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_395878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793384">
        <property type="protein sequence ID" value="KAJ3784243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="748" mass="86184" checksum="FA9A531F3E5EDC6E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE71</accession>
    <name>A0AA38KE71_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fasciclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_14390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793360">
        <property type="protein sequence ID" value="KAJ3784873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041296147" evidence="3">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="232" mass="23556" checksum="668D4636497465B4" modified="2024-01-24" version="1">MVKFSVTSAFLAALALFVGPTIAQSSTSSAAGSSQTIIVTVSNSSSASNASSVFNPDQITAGLGDLVLFNFTQGNHTATQSAFFAPCEPVNYTNGTNGFDSNFVVVPANFSLQDGAFPILAVPILESNVNQTMWFYDVNTCAEGGVGVINLVAGDPATNGETLDGFRRNAVRLNGTSTSSSSSHSSTSTSSSSSSTTSSSQGNGAVQRFGLNTGAGTIIGLVLLAAMPLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEX5</accession>
    <name>A0AA38KEX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stretch-activated cation channel Mid1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_436050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041244592" evidence="2">
        <location>
            <begin position="21"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="479" mass="51129" checksum="DD385904964FA557" modified="2024-01-24" version="1">MLPETLLCLVNAALIQAATASLSINTITHLNFQDLPSPPTFSLPAAQNLTITVAFCSSETISTRFFLTNVTSVDDPGPDGDADTYEITVNQGLGTFSASFLDGGVLAIDGASSDDFSFEIGTSDSGPMHQVLATFPLLGDTTSNQALLFSPSFDPPVFSDPSYPNYTLPGPSLSPPSPPDSYPNFTLIISPTSSQTLTSLPQTACMIASQTSSGNIANESLWLRDEEGWRTQWILAGLSPQTNYTAYVTQDSMKLSGPLYFVTKSAVFACPLAAFLPYCPGVTYAIPLPSPDNSDLSIYDSTNLPSSISDTLIAYFTNFTTTLTTQACGRDYYSPLQTCADCQRAYFRWLCSVSFPRCGEQSPSTTTTTTASSIQTSSSTGIPTATSALQPQTTSSTPRNSAFSSMNMPYSVLLPCIETCQAADRACPNFLGFACPLTRFNANQSYGVGYIDGAEPDQQGLGVPGEAQDQWGNIWCNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGQ9</accession>
    <name>A0AA38KGQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_394725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGQ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="28"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="371" mass="41869" checksum="01008206BE57B425" modified="2024-01-24" version="1">MPSGPLYGANPATQMIHSGMQQASRSSLQSPLLQEFHANKARNWELRDIMNHVVEFSGDQHGSRLIQHKLESASSEEKQKVFDEIVPHNVLPLIQDVFGNYVIQKLFEHGTQVHKSRLAAEMEGHILALSKQMYGCRVVQKAIEYILPEQQASIVRELEPHVMECIHDANGNHVVQKLIERVSPDRLGFVYAFRGNVQALATHTFGCRVLQRALEYLPETITSPLMEELRASTLLLMQNLFGNYVMQFVIEHGKPQDSAAVVAKLRGQLLVMARHKFASNVCEKALIFADPETRRQLVDEILSPRPEGAVVLSMMKDQYANYVLQRAVGVADIDQRESLINQIRPQLAILRRISNGYSKHLVSSELIANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI04</accession>
    <name>A0AA38KI04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial half-size ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_345682</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF648">
        <property type="entry name" value="ABC-TYPE TRANSPORTER ATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="303"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="621"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="945"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="984"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3788636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1113" mass="121992" checksum="667D67F0575DD4EA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKU0</accession>
    <name>A0AA38KKU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_249818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793939">
        <property type="protein sequence ID" value="KAJ3780075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKU0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="116" mass="13507" checksum="EBFB149828C9A3FE" modified="2024-01-24" version="1" fragment="single">VRRRYDIPESDPVDLTAISDTPDGSRPDATLAKILHLAIAGSPRKKLTLREIFLAIKDRFAWYKNSEDKRWQGSIRHMLSMKAEFVQVPRPFMEPGQGHYWTLNMNLTGDKRVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL85</accession>
    <name>A0AA38KL85_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_300987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793717">
        <property type="protein sequence ID" value="KAJ3780510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL85"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041219969" evidence="1">
        <location>
            <begin position="22"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="464" mass="52729" checksum="B3EC8E0C2D1A2B7D" modified="2024-01-24" version="1">MKICLQKLVILSLFIVSPAYASSGSWFGSSQDSDSSPSPYPSSFSSWTPSQYSSFQETFASLRDSTFDAWDESRLREWLLVQGIVAPKGTKEELVLIAKRRWRDWQEANEHYSSAASETASAYASDASAAAFGAASTVSSYAAQATADVLSKRPFDSTKDYVWSTWDDTAVRKFLVDKGVIDTRTAAGKKRDELAQLAQTHYESASGNVWEIWSDSYIRDWLAAHHLIDTRNSVQKTRDEYNKHMQSYYYDTKQHVWDSWSDSDMRTWLIDNGFMKSDAVATRDEMKKAIQKNFYSAQSTLTSAWSESQMRTWLIENGYLRSDSQVRKDEIVSLFRAKYYSAASIISSSTAPYLTWPDARLRAFLRESGVSESMLPTSRPSLLQEVRIRWVRTSTSAERMLARLKEVLDDNVVGPVEDRLVRAWEVLKGAGGDSQEYAEEKYGDSQRVFEDMKGRAYEKVNGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KME2</accession>
    <name>A0AA38KME2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_276204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793498">
        <property type="protein sequence ID" value="KAJ3782115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KME2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25669" checksum="9256C59749BA8AB7" modified="2024-01-24" version="1" fragment="single">MSDSDCSLVDEPIRITPPKNHDTSSAQAQVPTASELETLLTHPLLDEHGQKIEFGDILNAPAKDSEKTVIVLFIRHFWCPLDQDYVQEVVDILRRLSEDDGKKAIPEVVIISNGSSALIAKYKEIFDLAGKKGSNLKVKLYTDPTCRTYRILGMENVGEACISFPYKSYVKHTSTIGGIASVVLRAIKVGMPVWEKGGAIKQLGGELDTGIQVACAFAHRMSDTQDHTPFGDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMY2</accession>
    <name>A0AA38KMY2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_362560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793449">
        <property type="protein sequence ID" value="KAJ3782850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMY2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="242" mass="26729" checksum="A5C21D0B8C9E7245" modified="2024-01-24" version="1">MAGISWQYVFKFIITGDAAVGKSSLLIQLTDQRFIANPDPTLGVEFGSKLITIPEENKVVKLQCWDTAGTESFRSITRSYYRGAAGCLLVYDVTSRKSFLNTRTWLADVRQHADPHLTCILVGNKVDLCQDESETQAEFNAEPISSVPPRSEFSNSKSKRQVSIEEAELFAKEEGLLFVESSAKSGLNVERAFEQAARDILEKIHRGAFDDDQSPGVKLSKPATGNNLVLDTARSRSVCCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPE9</accession>
    <name>A0AA38KPE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_388388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793380">
        <property type="protein sequence ID" value="KAJ3784350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="393" mass="44856" checksum="3464F630DE555055" modified="2024-01-24" version="1">MATTRAGNEIWSISKANVSLNLVYDTTQLRALVLSEVVDPWKWLWELGFDWVTYIMDLLQQELNDTRQLSRLSTRHHIIDFRREENFTSQYRRRCLKSLRILARTFCVLPNSFYLKEALVREGTHAVSGGGFADIWRGRFNNMNVCLKVLRMFTANADASQQLRKEFCKEALVWKQLDHPNVLPFIGVNEVLFSPSYCFISPWMENGSIMAYLEKHPEHDRIPWISQVGEGLQYLHGLDPPIIHGDIRGANVLIADDFHCCLADFGLALVAESPSLHEKSVSLRGSVRWMAPELLDPNLDHLYQPRTPRDIYAFGCTVVEILSGSPPFPSIKYDIAVISQVLRGYKPEIPDSLTRVSADLSGLIYNCWDLVPSRRPTADDVSSFLSFYNSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPW8</accession>
    <name>A0AA38KPW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_356430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793360">
        <property type="protein sequence ID" value="KAJ3784875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33317" checksum="544D42767D30F7F7" modified="2024-01-24" version="1">MSNESSFSYHPLFSSPEADTVISSLEGTLYRVPSFVLRSTSRFWDTLLSIPSQSTSTSSPIPASQNNAILEPMLCLMSGLPIPPWTSDPESEESDEKCITEIENLLMLAESWDAPGPLSFLRLGVTSHMFLEQPLRLYALATHFGWVPEAKLASKYSLGLNLYDDEYEEVLRRLSAKDLLALLRLHRARRDGMKSRLDDPNVFALGNSGTSSCSFCNGTDEVDHSAWRELKARIFKEMDQCSKGDFIGSWEMEEWKETEQCWKVKCRICSRLSYHKGQTILKMKEGLRLLPETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQT2</accession>
    <name>A0AA38KQT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_160722</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3786914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="549" mass="61496" checksum="5F3A42C15C50819E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQU0</accession>
    <name>A0AA38KQU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_387075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQU0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="359" mass="40664" checksum="18B82DB1257C15A4" modified="2024-01-24" version="1">MLELRKKQAQEVFQEQLNILQFYNKEDVRKRIDQVKQDIKELEISIIPALREILASSKSSFSMGDLLESKFDELYIDLRQLAFKLGISPESLVSPGIEGLAFTPGHNQGTTFNDDTIMDTFVNWDGGIPDCANTELNVYHPFTTLPRLPSCVPLSPFTFTPPDGALMDFTTPRSSSEPNSRISIKNPTTTQENEVNKGSVIPEYIAHLYNKREQVTKLREENEHAAEVILELRNQVSSFESLSGARRKMLGRVKAQLEFVQSPDPARREWFDAARAITDRIIGCEIIPILENSEKEVRNQLVRKVEEKRPGMTITANQNLTDSGLSRSSGNDLPSGSGNRVQQQVWYQTWRPVARVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSK9</accession>
    <name>A0AA38KSK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_263592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSK9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001763">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="189" mass="21376" checksum="AD38D74210F31CAF" modified="2024-01-24" version="1">MAQFKVVVLGAGGVGKSALTVRFIQGVFLENYDPTIEEEYRRSISVDGSLTTLEVLDTAGAEQFTSLNEVYIKAGKGFVLVFSLTQEASLKEVDHLRKQIYRIKGESGSIPIVVVGTKLDLVNEREVHRNTIQTLASRWNLPFYETSSKRNWHISDVFEDLVRQMRARYPPEQPSRRSKGPKRSPCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KST1</accession>
    <name>A0AA38KST1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane transport protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_7623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794298">
        <property type="protein sequence ID" value="KAJ3779727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KST1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3779727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="599" mass="66526" checksum="A071C1009CBFF81A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTD7</accession>
    <name>A0AA38KTD7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793740">
        <property type="protein sequence ID" value="KAJ3780432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="157" mass="17135" checksum="E31D208DE1527C27" modified="2024-01-24" version="1">MTDPVTGAFIEEVGKPKAPEPTTGRNSKGWKAWKDKRDEAAAVIVERIDPDQCVHIKGIDDHPLAMWEALASYHTVKGLGSVVSVYKHLMAAQKDDLVTISAHVKTIRAGLLESLGEPITPSFIVSCILVSLTNDYQPIILKLDGDHMVSDIDYVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTJ6</accession>
    <name>A0AA38KTJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_321489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793684">
        <property type="protein sequence ID" value="KAJ3780627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTJ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="928" mass="106088" checksum="138B70D83A7A6912" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU07</accession>
    <name>A0AA38KU07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_390682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793569">
        <property type="protein sequence ID" value="KAJ3781362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053205">
        <property type="entry name" value="GHMP_kinase_L-arabinokinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134:SF2">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134">
        <property type="entry name" value="SLR1395 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="691" mass="76208" checksum="4E6BEFC62E6731C3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUB2</accession>
    <name>A0AA38KUB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_262979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="169" mass="18150" checksum="8282C2D45BB27807" modified="2024-01-24" version="1">MINVTVDDNDHSILYSPAGAWNARSAALSCSACTAQPDPTKMVSGTWHDSTFYPIDGGTHDIPNTPLFANLTFNGSAVYVFCALAESVKSPDGNSDMAFYVDGQLMGSFVKPALGINNTYEYQFPVFSANSLAPGEHTLVLQNGHVNGTQSLVLLDYIVYTYVLIDTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV39</accession>
    <name>A0AA38KV39_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family M48-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_361281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV39"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="412" mass="45218" checksum="FE0CE535C4FE1CC9" modified="2024-01-24" version="1">MLRHVCGRESYQSLSRRLSHPPSLSYHFHSSTIRRSSPPPPRYVRFSPPSNPNSNSGGGRRNGKSFLEDRTWPVKLGAGLAGMGVIYYVSCLEQVPETGRWRFIAVSPETEAEVGKMVLQETMAQYKGRILPQDHPVTMHVKRIVHNVLSASHLGIVKGYSEPQKQLLGNDFGADDVWSASSSTNSPPSAIASANKEWAVVVVDDRKFANAAATPGTIIVFTGILPVCKDEQGLAAVLSHEISHVVARHTAERLSSQTIATALGLFLSIFGVSFGFSATLNTLLLELPNSRLQESEADLIGLRLMSKACYDPRASPAMFARLAQLESQASRGGFGAPEFLRTHPTSESRVRDLQAHLGEGYDIIAANPACAELQDQVQAFRETTRLRNAFNLGHNGHVHHKQHGEDEEEVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVK4</accession>
    <name>A0AA38KVK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_271707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793380">
        <property type="protein sequence ID" value="KAJ3784347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVK4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="254" mass="27773" checksum="B0A8FD95D7EC0420" modified="2024-01-24" version="1">MVHRSADSRLLANLISHEKEYTNQLQSLLNLSHASFNSLSAYAASSPPPASQVILAVAGSLSNVDNALRVYAAAVEEWTKYLKELKDLEDEVGNVMRDREILVTRLLKASKSTPKPSSNRDSLMFSSSPPASSSTLSLKSNEDPSTTYASTSFFSALSPGPTSANKKLQTAQAELQACEAHLAKKELELDGKRSSAIRDGLRIRFRALGQCGWRWSEIGKEVEVVLGFGEQGSAYYLVVSRLIVMHFSLYATNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWX3</accession>
    <name>A0AA38KWX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_394457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="360" mass="40801" checksum="C27EB8DB5009CCC3" modified="2024-01-24" version="1">MFDTILPADAVEFCPHPAFQDIFVCGTYNLLKSEETVRTRPQERNGQCLVFRCQYDKDDIAQSSFDKIQEIDYPALPDMKWCHRSAASKATLCVADSKGEVHLLDWNSDESRLEETVRKQIAGSSETLCLSLDWSNRRNPTSNLGKLVVSCSDGDLVLLDHTTSSIEVTNKWTSHEYEPWIAAWNYWDTNMIYSGGDDFKLKGWDIRTDLRDPTFVNKRFEAGITTIQSHPHIEHLLAVGSYDASVRLFDTRKPLVPLSQTNIGGGAWRVKWHPSAARKSDLLVACMHDGFKILRFHELGVETTLEEMAHSSSVSVVQRFDEHQSLAYGMDWSFGPSSSDQKTAIASCSFYDHSLRFWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX28</accession>
    <name>A0AA38KX28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_367125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793572">
        <property type="protein sequence ID" value="KAJ3781328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX28"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="321"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="783" mass="87107" checksum="63FED57D44B61392" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXD4</accession>
    <name>A0AA38KXD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_373921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="133" mass="15253" checksum="B9CFB1D4D5157785" modified="2024-01-24" version="1">MNDMVAANFRLNLNEVAILYVPKNTQLGIKDACVVQVIVRSIGMPFNRSPSVDDRATFYCYADEISKVVQNVVLGHLTCPDLPIDLVVQGEKYILRANRKDWNTGKDYWFKWGDEIINAAPEKWIFELVPMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXN9</accession>
    <name>A0AA38KXN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_335669</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793486">
        <property type="protein sequence ID" value="KAJ3782288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000502">
        <property type="entry name" value="Pre-mRNA-splicing factor cwc2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="151"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3782288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43468" checksum="3D4C51F0091B1D9A" modified="2024-01-24" version="1">MSLNGTETAVVPVPTKKAKTKKLRPARKQVKPGDVERKETPQTGKEYNIWYNKWAGGDREDSYSNKIKSQTRCNVKLDSGLTRANTTGMKYCCLFFSRGCCPYGWECEYLHTLPDPSTALPDSSKDCFARDKFADYRDDMGGVGSFNRQNRTLYVGRIKETGTGLETEEVVRRHFKEFGEIEHDDSETGWAVKVLQYRSVAFVTYKSELHAQFAKEAMACQSLDNDEILNVRWATEDPNPVSKVNEKRRLEEMGQAVIREKMDPKVVDAMRTIRALEDGDVLDADGNLIENSTMDADEEEDEDEGVDRGTKRRKLDVYEEISTPLPPEEEPPKSIGLLSADTMDSLKYFSEIRKRNGIPPPTALRAAPQKTSAGLGLGDYGSDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYC2</accession>
    <name>A0AA38KYC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_361568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793431">
        <property type="protein sequence ID" value="KAJ3783203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYC2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="208" mass="24206" checksum="80627D2A5AA10B4E" modified="2024-01-24" version="1">MSSVETEAERVIQANPENRGPGEDENEIKIEIENGSKGDGDEDPYKLARMHAFQLSVLSHNYPPVNNDLPIGTKDLPAKFQVEPKTLEPKAPKVYYGFGLYYIDCVQYLKAHHFESRLPHPTLDRGTYMWDICLTFLQHITRCCNFGFIDIQPAKTLEFDLILSLYDNHTIWSRELVEAEEEDVISIMRKEMPVLNDRELRWFYPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZ36</accession>
    <name>A0AA38KZ36_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_356745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZ36"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="83761" checksum="DCF4B1BBDD334861" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L000</accession>
    <name>A0AA38L000_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_418239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L000"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="53878" checksum="CDA8CDF348F94454" modified="2024-01-24" version="1">MGLKIEHGHTTGCFGGFKLRFSGKSPATRTLSTIRSEPAPSKPGEKMLAPSQHFDFGVPSGWGLSAEQSSLDSFLPPYTTQMNASRTSGVVDSVAGKTINSVLDELEPELYQLSMDIHDHPEIAFQERYARDTLTAFMRRHKFNVTSEYLGLETAWRAEYSYGNGGKVIGINSEMDALERIGHACGHNLIAASGCGIAVALKAALETHDIPGRIILLGTPAEEGGGGKIILLQRGAYDDMDFCLMSHPGPGPLYSFDIGATTAVQTFEVEYLGKGAHAGAAPWYQFLHRTIRSEGINALDAAFLAYSSLSVLRQQMQPTHRSHGIVQGRDWISNVIPDNARLRWQVRAPTYDEMSILAQRVRKCFEAAALATGCSVNIDEEPPYQDLKNNPILARIFGQIVQTQYGQNVSTNGSAASTDFGNVSYYLPALHPLYTIPTEPHGGNHTPAFTKASATKEAHAASMIATRGLALTALCVLQDDALFLEMKASSVAFRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L099</accession>
    <name>A0AA38L099_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GGU10DRAFT_288020</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L099"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041346069" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="18"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="204"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ3787583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="485" mass="50881" checksum="DD1E407097513FBC" modified="2024-01-24" version="1">MKLQTLSVLLAIAAAHASKINPLHIKRQATSSTATSATVAASSASSSSGTSAASSSTTGISTGTATGSTTAVAVPASATWGTSFPPLSQISSGMPSEVTQPVTTTYSPGTSPTYFSGADPLPTAFVFNAADWPAQDKLPDTSSSEVQEWMKELDGWDIPDLSPTVDGTCVSDPTNVANASARGWWTCGGYTRDTDITVCPGKPMTWGTSFDDGPAFYTTKLLHFLNEQNIKATFFDVGSRCIENPSVLIDEYMSGHEIAVHTWSHPHLTTLTTAEIVAELGWTRKAIKTILGVTPTTMRPPYGDIDDRVRAISLAMGMVPIIWTRTPAGVSFDTFDWEIPGGVVTSEASFTQFEAILGNASTLDDGFIVLEHDLYEQTVDMAIGYTLPAALSHNPPFTLEPIGQCNGIPYTNMYVESNLNTSFPIANGTSDGGIDTDGDGTGDAKSKNGTSSATSSSNGAPPRHVSYSIYAAITLATLAAVVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0B5</accession>
    <name>A0AA38L0B5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_347998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0B5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF562">
        <property type="entry name" value="DNAJ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="436" mass="49448" checksum="C71B322836CD5333" modified="2024-01-24" version="1">MHFKSKPLRDHWHEVLGVSDDATRDEIKAAYKKLALSWHPDRHTDDKNLATEKFVEINNAYRIIMRERHFELANVSVNDLNPVRPQFRTRTSTESSTPRTRESSATIGTLSSSSRQSSFESMTTAPSTSRFSMRHVSTSCDALPYLVPGNSPFYPRVPPPQSISNVLESHHFRASGERPSIFPGPLTDSPLQTKMPNLPRRSTDNSSFNDHILMNRILAFKDTPPMDNRPLHPYNPPFASIGVGTSKEWRYSLTLTLEELFHGRICPIRITRRYLSGEMKNVVLDVDVPPGSRPGAEIVFRGVGHERSPGRFQDIVFVIAQATHDRFVRADNDLLLNTKIPWSDNLKTQDGRLCFPGIDGKLLCIRIPRPSNRSRGSLTGSQIVCDAGMPIWFGAKIVGRGNMVVRWEILIPQISRWDYLKTTFSFYRSSLSCAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1T7</accession>
    <name>A0AA38L1T7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_321638</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793716">
        <property type="protein sequence ID" value="KAJ3780517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1T7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3780517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="541" mass="61113" checksum="8CBD725D1DD29E45" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L253</accession>
    <name>A0AA38L253_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794730">
        <property type="protein sequence ID" value="KAJ3779515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L253"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="418" mass="46558" checksum="B13BAF74798F55C3" modified="2024-01-24" version="1" fragment="single">NFLSLEAEEAGESDFEEDENEIDDAQFIDDAVRDDSIRSSSSSSLSLTAKPDRTTWLDPVIQKYGGSVSEDRTSAVSETSSNVFDPHSPNLPVSPMRTSTTMDSSITSAPPTARPAPPSTNSIPSTRLPAPSMQSSITGHRLVPPASSALTEDALRSFDVTFSALSQEDDDEDDNKAMVTSGDPVLMNLLDELVQQSEDVSLFQVYSVHCRLGTENNIVGRIREDIKQGSISSNVINDAFPSKIPGRVYLVVLNMHRQNTTLAAYLSSIDGFKYRNSRRLPTKEVITGTRLRTRDDGTTYMTHTSSVPPIHQSLSLDMPISTWVPYNDTYFSRLHRRHEFIKPGTWVQPKRGLFKGDVGVICKTLPQTHECLVLFIPRPRLPDNTGNKRKRMPRPQPKLINLMDPLFRSLQVKESHPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2A4</accession>
    <name>A0AA38L2A4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794203">
        <property type="protein sequence ID" value="KAJ3779800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2A4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="393" mass="44441" checksum="031387375AC9FCA7" modified="2024-01-24" version="1">MKRVVHTYNNEAEEQQAFYLKSANGTIPNEAHDILLDLVAIDKVPANKVTHVFKRIAEAFGISIHGNVDRRSVGRIVKEGGNAAKLQFGQAVIDAKANRRLQFFLGLKMAINHTSETQLAGWIDTIEDIWHLLFESGMCSEEDARVFWNLVTGFHSDHAADQKKLFELLRKWKEHCDREVRSEHIIKRLTDLEYACLIFQGSQLLIENVGGPAAWEAMPVAKHTAQLEVMKHQIIRDIGEAEYAKLAETEKAEVDFFLWAGCCMHKEMNAFKGGCVGFDNFWKAHPELAPPKLLPNRDNAAAINKAVGTEAADRALQRSERGAIKVMSLAGAVFRHKDRKRGQQDTLRFFFDHKLGFNIAFPDTSNTRFQSHAEASAVIVTYLDLFIEFLTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2M3</accession>
    <name>A0AA38L2M3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_255889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793812">
        <property type="protein sequence ID" value="KAJ3780280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2M3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="142" mass="16411" checksum="753B05853C7452A3" modified="2024-01-24" version="1" fragment="single">SERAAYDKLLGDTQIELDRCQKEIDRLEILCNTLIASKQLLQANKRLIHSILSPIHKLPLDLLGNIFEHLCYDRNYLYGSSLPNVPTLNLSSVCHRWRSLVSSMPILWSTFNMIEKEFARPHNLLPLFLGRSHPCPIDFQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2S5</accession>
    <name>A0AA38L2S5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_363998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793479">
        <property type="protein sequence ID" value="KAJ3782392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2S5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072:SF4">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="339" mass="36810" checksum="6A7CDA2169370203" modified="2024-01-24" version="1">MSEIPASADSAQGETPPSETAAALSQSVSANTVALASGNARYTDTDDMVLVDCVIKHRGTFQTDSGFRPALWPIVLKTLLNDGSNVGGPKTSKKVADYFGTLKKSYINVKWLRNRSGFGWDEGLTKVTATQEVWKALLDDPKYGKWQNKPFRIYDKMAELIDGIYATGVNAISGGDSAGPPPQPSPGPSPLSRSASAPTIQVVHDKDSDDDTEDTQAVTVTPGTHLSANDMSEAPIYAGLAVKRSHTKIGRSTPQSRSVDSVAGAINRLSGTFENALNTPKRRRLAIKKFEEDGEMSDDESTRVYRLFQKDISIADTFVEIGSKQRRTNFLRSVLYDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3Q1</accession>
    <name>A0AA38L3Q1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3Q1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="504" mass="55758" checksum="7614BA30C57857D0" modified="2024-01-24" version="1">MSQTEDVVQPAIPRTPSNKKGQTSIFDDAHKTPGQSSPNRTRRKTPGQQTPSRGNSVSPTPSNRVRRSVSTTSMDSGNAAADDNQVNDQAQPVPSNPTSHNLSDRMSTASDDGIPEGQTRDIMDELMHASMTLAPGTHLPTVLNMESSGNTANENPREDDDDRSESGAATPTPELPLPTYDQEKLKIPRDRNLRPNGTRPEQGPTDPGFAEFLMCVATAPASLNNGWMPEFVRDLETSLRGYPEEMRQEILEHPKEWILLTIFNSGVYLFRRIPDMAQKIADFLLNIGIDFEDILAPYRDKIEEEAASASRARGRGGANPQASRGRGRGRGRGGKTTPYKTQGGESEDKYGGSTTLTVRISDINQRHYLLGLGTTALDTLVAFHATKVWHSPEPVPYERSWAAGLFHTNQYGRTNDVMSDNLAYTVKLTLWKSVAFGDLIARANPGPTPTRQKVIEFMNSFEFILQPYKYKSANINQACWILFAAPVSRHPDPMTHAKQENEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4C1</accession>
    <name>A0AA38L4C1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793351">
        <property type="protein sequence ID" value="KAJ3785152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4C1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="113" mass="12821" checksum="2903631B2D078769" modified="2024-01-24" version="1" fragment="single">MKVLLEKLWQNLVFRRMKSLLLPNDSDPSAECYTVPVDEVRSAIEESKLGFNPDPDLFLIHSSDVVARSDLKKSWQILEQMKDTGEPTEIGVSNFHPQDLELVLYGGKHKPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4G3</accession>
    <name>A0AA38L4G3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_398513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793343">
        <property type="protein sequence ID" value="KAJ3785392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4G3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="98"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="529" mass="59514" checksum="6BD2FA0B3E94DD23" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4N3</accession>
    <name>A0AA38L4N3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_353716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4N3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="423" mass="45589" checksum="315ECB034C204399" modified="2024-01-24" version="1">MRRYASAGNLLSNSSSRPSSSNSGHQHSYSHPTPFSTTSITSSPYNSPPLSLPESSDVPAVITSTRSRASSSAGQMGNSRNRSRAGSTVLRNAVYIQALDSNEVERRLLTLSPISDREHSVNDHPYISASEKEEENPDFGQSKWSPASSVVDLRSSELKISTDSSSSFFSKILGSQAPPPTPSTPFSASRSGSYIGLADTGVHQSPTTEDAPKSYLSMNVSKRKSLISAFPVPPSLSQSDLQADNVSVPPVAPVRRPRLASFIARMTGNVTSQVPPVPLTLSSPSPTSPTNISSSSVPPSPTNLRTIQHRPVPLDLSLKPKNSPATDSVSMTGTSEPSTPAYSSSSLSEDSGSETETETEDDMDALLEHRGLLYPPPQAGRYLMSVETTFLLLLRVWKTMPRWLEAVMLKCMDSDYPKRHPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4P8</accession>
    <name>A0AA38L4P8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_434223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793329">
        <property type="protein sequence ID" value="KAJ3785872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4P8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="92" mass="10242" checksum="0A798B1619BAC12E" modified="2024-01-24" version="1">MSDEYGGNSFKDSLVDDSINPEGATINERFKNYPPENDTTSSGGFSTTQEMWSDKAQRGNKFEVKPADEHHQSLNGSNLKDELQDAKQGKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L535</accession>
    <name>A0AA38L535_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_388092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793367">
        <property type="protein sequence ID" value="KAJ3784675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L535"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57107" checksum="918E3D0C534B0CD7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5L7</accession>
    <name>A0AA38L5L7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">GGU10DRAFT_373837</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5L7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="296"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="578"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="824"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1096"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="682"/>
            <end position="684"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="689"/>
            <end position="695"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3787582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124236" checksum="EB225F4BFCB670E4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5N0</accession>
    <name>A0AA38L5N0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic rRNA processing protein EBP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_308704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5N0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="410" mass="45472" checksum="C42BD3F35D809A7C" modified="2024-01-24" version="1">MSSTKKSKSVLKSAHTNVALSGKLHKIKDTKTKETFSRVEQIDESEVEADAGEDSEEDDDGGIDEEGMERLMKALGDDGLDEFEQAQLEAALDGADSESEEEDGEEDRSEEEEDSDEDEEEAEGDSDGDTEGEQEGDGQFIELEDIEAVIDDAVPIQKVEINNEVALARIRESIQLDPSLPWTETLAVSYPHTIDVDVNDDLNREMAFYKQALHSANHARQLVTKSFPTFPWTRPSDYFAEMVKSDVHMERIRQRVLDEKAGIKKSEEKRKEREGKKFGKQVQIEKLKDRERGKKEMEERLKGLKRKRKDVLDNPDGNDDAFDIAVEDALSDRPAKRGRGGPGGGSKLSRQGRDTKYGFGGAGRRSKQNNAESTDDFSGRGGRGGSRAGGAGRGGSKRLGKSKRITARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6C4</accession>
    <name>A0AA38L6C4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MOP flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_427011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6C4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="500" mass="53844" checksum="D15A326DE00D814A" modified="2024-01-24" version="1">MPPAPTESDPLLTQAAQLPSSSHNAENPTNLTSTSGPQADGDIKAESKLFFSLPNTVILSYILQNSIQTISIVIIGRLGPHELSVAAFSLMLAFAALDTLGSQAFTGSTRPTDLSVHLQRCILLLWILLIPVCVLWTFMRPILLALGQQDDLARDVQKFLRLLIIGAPGYIGFESMKKYLQCQGIMGASTMVLLVVFPINVGLNIGFVYYSSLRLFGGPIALSITYWLAFALLGIITFFSPTHRRNGTWGGIQFRAVLQWKGCATFFRLAIPGILMVGTEWAAFEIVALAAGRLGSLPLAAQSVIMTLDQILNTLPFGIGVAASTRVGNLIGLRSAIGAKHAAHAAAFLSVVVGAVVMLTLISTKDIIGRLMSDDVAVIQLVSGVMPFVASFQIADGLAGSCGGSLRGQGRQHLGAIFNFVAYYVLALPLGIFLAFRLDYGLKGLWIGQVVGLTLVGVGEYATIWFCTDWVYEVEKGVQRNSEEAKRLVQIRNLRNIEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L708</accession>
    <name>A0AA38L708_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_410179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L708"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="744" mass="81480" checksum="F33979A98BF8AF8B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAY7</accession>
    <name>A0AA38NAY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794411">
        <property type="protein sequence ID" value="KAJ3779671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="35430" checksum="EF608E4805D83DC2" modified="2024-01-24" version="1" fragment="single">RNTTHASLIQFVEDFETLYYQRFIERMHFCCPCIHYCIHAVPETYRMGPLGLISQFTMERTIGNLGEEVRQPSNPFRNLSEQCKRRACVNALLAMCPELDYTVSTHACYSVDTGHGYILLHPRDKGSISLTTQYPEAAFLFDDLLGYRKIRRYGRLQLPNGQIARSLWSETRQANSNHTTRITRNVLVGEINIQNKIAKVQFFFMYWTAEEERNPDATGAPYALVSLYSECNEQLLRESHGACWTGKYTGNNGLKIVKGSKIQSILSMHPLLHVPGDPPEYEGLWCISPRSGLDDIDITGFNEIDGDLGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND68</accession>
    <name>A0AA38ND68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_352414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="339" mass="37614" checksum="475C95E9EA9303BF" modified="2024-01-24" version="1">MSTKKLILVIGATGVQGRPCVSALLAPQDDGTPSLYSVRVLTRDPTSQQAQGLASLGAELFKGSFEDLETVVVAFEGCYGVFVNTDTFSVGEQKEIYLGIKMFELAHRAPQMRHFIWSGLDYGSKLGNFDPKYIAVQSDGKGIVSDFLRSQQSSPSGDLLTWSIITTGPYIENLGGVLLGPLAERENGAVVFALPVGDGHVPSISLEDIGWWVRYTFDHRSETSGQELKIATEMLTIDQLVETFTRVTGIPAIRKRMSVEEYLDRYPHTAQSIMRGEKGPSIKENFAGMFRVWGDDLLTRDMEWIRRVHPTGYTLESWIKEKGYDGTLSPDLKLFSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDG6</accession>
    <name>A0AA38NDG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_349758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDG6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041394472" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="213" mass="22115" checksum="91BD7CCD706094A0" modified="2024-01-24" version="1">MSFLIIIVAVTALAVRAQSPAWGQCGGIGWSGPTTCVSGYSCVETNTYYSQCIPGTATSVPTTSSGSSTTATSTSTGATPTGSQIRSDQDPTFHFYLQNSDGSAVLGSETSSGYFTIGSTITLPGDNSTTLYLNVDTSDTTVSYQALTFGSTATTTDWGLEGDTIIETDPRQLNFLTCATSDPSVYSLYLQTGNDSPAGQTCSLTSLHLDCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDZ1</accession>
    <name>A0AA38NDZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_263205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="305" mass="33739" checksum="6EB1CB1E9E294ABE" modified="2024-01-24" version="1" fragment="single">VIGASGTGKTTFINAVSDSHLPVGYSLEPCTTTIQLSSPFEICGHKLQFVDTPGDEDTGTLKSISEFLAKMYKGGSTIAGILYFPNLSGPRVGGIGRRNMRVFRELCGEAAMSKVLIVVTGIDPSSTAREVELRENPKFFYAAIQDGARLLRYDGTTECAKGIVSHLFEFEVAEGEKVVLKIQEELVNDSIKLSNSVSVAQLDPDLIQAMRNFEEGLEGKYFVFYTRKVNDHDLIEIQTNKITASMEPQLLFAKLEVEDLRSQLVDTLAEKDQIANAYKVLQEQRLSLQHAVLLGLMLIVAWWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NE95</accession>
    <name>A0AA38NE95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase III subunit Rpc5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_425896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NE95"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="280" mass="31530" checksum="717D3FE5E2E090C2" modified="2024-01-24" version="1">MNEEDEIITKIPIRLSNRLSLQIHQFPLLSRPLQAPPSAEASGKRITARIKPQSRVLEIHVPVDTRPEVYNTERGHELGKGQLDDDREQNQERKGKGREGEEPRLAEVRLRSEEIPQRGVQMLGIVHENELHLHPISAIHQFRPTLTYLDIISRKSRRRGGDDSDSDSDDGPPPDPDEPAPTAAPPKKEKKTAAGEAKEVQVSARRIDDKAGNISQLSNARKEMLAIIRAEQEESWQNLEFCGMTTEEAGHSLDQFFSYNNEELHCSTDVTTFLTTAPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI02</accession>
    <name>A0AA38NI02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycopeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_363842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI02"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="196" mass="20524" checksum="0D55E5C7BA8DF61E" modified="2024-01-24" version="1">MIMSTHQSMEDILKFCQYKDTSQNPEKTRISSSNFVHQMFFSMNLAALVAVALVAGAQAETHTVVFNNLCGRGVPVLKRNGATLSTGGSFTSNGPLVAAIAYLDIGCGADGEGCTMVETTLVNPTTPGSGSSTDITLIPPHSFSVTTGFGYFNGCDGAGADCTNANCPTAFHQPDDTHVQVACQVNNVNLAITFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIG7</accession>
    <name>A0AA38NIG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794342">
        <property type="protein sequence ID" value="KAJ3779703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="297" mass="34387" checksum="587FCBBB08C1A745" modified="2024-01-24" version="1">MNNNAKASGSKRCLNDDGDNERRRPRKRMEDRKKERLARLRQKLRTRQAIVRKEEEKEQRDEENDKERRNKLPPVEEPPVPLALRSDFPSNHWVEPSEEYLDLSPSYPDNRVSVMVPPLPPSSPPADGLVIGAPRIPRCANCKIGARVGQPCIVQNARNRCTSCATRRIKCADDGTLAAWNARLAKGEKNGKRRGKLVKEVEEDDEEDEDQRDVSKVPRMGLRERYPRGAQSLEDRLLIETRRIGEQQEMTMRVMDRMEERQERIENELARIARMLEVRENEANEGSEGEEKDEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIK8</accession>
    <name>A0AA38NIK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_334243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIK8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041236581" evidence="2">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="231" mass="25265" checksum="53AC817B501BF25F" modified="2024-01-24" version="1">MIKLHPQLLYSLLFLFVPLVLANTEIVNFEASEQRGAHVAGAHDWHVLSPGANEKPFTVLPAPLGTRMNSVCSAPQDLLSKTPDCAHELWIKLDLDHANWKPYTKFTLRISWPGSSPADFGINILNPEATASRFAGTPITPPALTRVKFARIRVLDTGVISPLSGVTEVRPVPFIVTLEPLYLGVIPASIIPFLWTLLPVLVISAFLVPYANAYLQSVAADAKREIAGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIP4</accession>
    <name>A0AA38NIP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_397859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793884">
        <property type="protein sequence ID" value="KAJ3780153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIP4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="287" mass="32581" checksum="37D4F8EEE29E0893" modified="2024-01-24" version="1">MVADLNCDGYIDNDNILGQAEEAIDILLSDYPDEDHVLIFDNATTHLKHAPDAPSASKMTKSPSHFGIEVPAKGLDGKTLYDPSGKPQKKEICMSNGQLPNGTPHSFYFPPRHAQEGMFKGTVTILAEHGYGDWSKVRFECKKFKCNPAQEGNCCCRWKLYNELDFVNGKSLLERACKACGFQCLFLLKFHCEPNPIKQCWGHAKYYYRLTPASKKEEDLLHNMLDSLDWITIQEIWCFACQAHCFIDGYKKGLDGKMAAWATRKYQGHWILQEGIMKEFLDQVAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIP7</accession>
    <name>A0AA38NIP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_358092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793381">
        <property type="protein sequence ID" value="KAJ3784307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="241" mass="27823" checksum="D6F22016148E14B5" modified="2024-01-24" version="1">MAQDFRNIYSTLTCGLSSEETKLAVMPPPPELMTLLVRNMIYPDILSAFIPDLLEVLSNVEKWRKIANARACHALMCDEYWPHYDKPYPSGLTNSDRKVLQVISNAQEVTRTKYIEILKQYCNLHLYNIWTSQSPVDAEHFTQVFQSYFASDTTELYLSLRDLTPTEKTQFTEVKKGWVEFITECAKNGYSVQPNVQITNQEQLAARTEAYLVLVQKQIDSLERIFDEDAYKYRVCGVSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJS2</accession>
    <name>A0AA38NJS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TAF1 transcription initiation factor TFIID subunit TAF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_311645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJS2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="5">
        <location>
            <begin position="312"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="946"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="873"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1024" mass="116465" checksum="7A77601B7BE5F3F3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJT8</accession>
    <name>A0AA38NJT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_176791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="32571" checksum="85A8267CAC367EBB" modified="2024-01-24" version="1">MFSLLIMVTLLGASSFGCGMLPLSFVFSKSHLSRLTTLGSGLLLGTALGVIIPEGIEALADAHPSSEISTSRVALSLLCGFTFMLIVEQMFALHSHSPAPGSTSTANIKPTNSSEIQFDAELGELEGEQGMPSRSTADWTMPVHQDSSPSQLQAIPLTLGLVIHSLADGFALGVSFFPSNESTGSSSLSAIVFLAIIIHKLPTSLALTSSLLATSLSRPQCKRHLAVFSASTPIAAVLSYLALDFFGGADHADWPGIALLLSGGTFLNVATLVSHRSEANLSEMSERTRLSLTVLGIFLPVLLSSLLGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK38</accession>
    <name>A0AA38NK38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_365065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793510">
        <property type="protein sequence ID" value="KAJ3781969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK38"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="465"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="539"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="68173" checksum="652D6ABE01326AC7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK68</accession>
    <name>A0AA38NK68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793502">
        <property type="protein sequence ID" value="KAJ3782074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="148" mass="16974" checksum="AAE15CEEC3A62FFD" modified="2024-01-24" version="1">MAGGKGGRPKKRARNISGLNNQSKQKSSDTAETRDHDDMDEDELGNDSELPEELEDWIACEKEEDSEDEVEEYEDDNLNDEFFGGEELQETLFEYAGAMDTDIRDEDWVPEWLKRKKKQRQEREKRGRPSSYSIGPESAVLGMGQIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKB2</accession>
    <name>A0AA38NKB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_378760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793488">
        <property type="protein sequence ID" value="KAJ3782254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="619" mass="70381" checksum="052FD8FF9E4C2140" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKD7</accession>
    <name>A0AA38NKD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_317713</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793445">
        <property type="protein sequence ID" value="KAJ3782928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="524"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1179"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="220"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="418"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="686"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="833"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3782928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1204" mass="136666" checksum="238725393A78BE88" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKP4</accession>
    <name>A0AA38NKP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_348390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKP4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="856"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="790"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1012" mass="105978" checksum="CD7143FF4B4F1214" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKR6</accession>
    <name>A0AA38NKR6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Survival factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_378046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793441">
        <property type="protein sequence ID" value="KAJ3783004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKR6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="5">
        <location>
            <begin position="51"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="6">
        <location>
            <begin position="224"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="421" mass="45555" checksum="FC8345453D42CA54" modified="2024-01-24" version="1">MFSSFFSTAPPTDPQAPNFHSVSSKLKPTELFGELKPKDTELLCTTSGFVTETQIFYITTPDGKSIMCQLIHSSVGLWYPTIQFTCKIYDSKTQRLTWKSIHVTNFTSAPPGLDRRSCKADEFSFTYKSKSDSDYPESYTVQANPAPDVQIFLEVTRPASVSGWKVGSGDEGGYSQFGPDPSHPEGYVVHRFWPLIKASGHVVLSGQATPVEGQGMFVHAIQGMRPNLVAASWNFGNFQSPELGGVSAIQMEFTTIDAYGMKGAGSGGVTVNVGSLVVGSKLVAVTAETKYPGETNNADAPVKSRVAHLSPVLDAETGYQKPCELLFEWAGPSLLADRPGTYKASIKADVGDVAQPKGLIEKVDVLAEIPKVLKMAVNYVAGTKPYIYQWMNPAKLAINEPGSDAPVEANGYMYIEATFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL37</accession>
    <name>A0AA38NL37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_388623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="475"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="496"/>
            <end position="503"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1324" mass="150532" checksum="04ADD36F3988253C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL39</accession>
    <name>A0AA38NL39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_286728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="767"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1201"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1156"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1687"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1687"/>
            <end position="1704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1740" mass="197479" checksum="9F17174DB6149A2F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL64</accession>
    <name>A0AA38NL64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_271867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793385">
        <property type="protein sequence ID" value="KAJ3784218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL64"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="88814" checksum="43BEAF4FB459C06F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLI8</accession>
    <name>A0AA38NLI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_21912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793366">
        <property type="protein sequence ID" value="KAJ3784713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLI8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="297" mass="33196" checksum="E596E79DB23D5D6C" modified="2024-01-24" version="1">MPRAKSLKDGRPNEANMAATCSVCQAVISNKTDLPRHMRIHSADKHKFMHRCPYTECNFENLQKSNVETHIRTHTKSKTNNCPDCDFTTVDPGSLTRHRKRIHGYIPKTRRSRHPKPTPTATGSPIATSEDASSHIHDTDEGTSSMNLQTQNPEFMIGPHHAQSQPEPPTSTELLMRTNFNQAPISRFITTLSSSTSISAPVPTTLKRVSRARIEDEEGEGRKEFADKDGFWKSSLGPRQTPPVEGKQVDVEEENSLTNKVTDQPVHCRIGNEDKNKPSGLVPALEYGTRPRPEIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLL1</accession>
    <name>A0AA38NLL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_357834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793377">
        <property type="protein sequence ID" value="KAJ3784414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLL1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="204" mass="22296" checksum="5686C6164DD32D21" modified="2024-01-24" version="1">MTSTAHPNLDPYVTKAENNSVSPHEKIKDLHEIVKSVETGMLTTRASTGHMHSRAMVPTAPQSDTQTSLIFFANKASHKFDEIENDAHVNVSFSNTKTTSWASYAGIAKISQDKELIKKHWHTGLSAWFGDLKDGVHKGNENDPRVAIIEVIPDEIRYWVATKGAVGRALETGINAVTGGVSVPGELRTITSSEIQLTQGLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLL3</accession>
    <name>A0AA38NLL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_305865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLL3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61221" checksum="3EB100132FE7FCC3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLM0</accession>
    <name>A0AA38NLM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_356740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793362">
        <property type="protein sequence ID" value="KAJ3784848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLM0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="33493" checksum="E5007A18BEE3F8CF" modified="2024-01-24" version="1">MAASISAIRTLNASFSPSYLPCAVFVGGTSGVGQGIAEAFARHTKGNAHIIIIGRNSSAAESIIASFPQPTSPSAKHEFVSCDVSLMKNVQQTTQELLSRTSKINFLVLSPGMLSLNGRDETEEGIDKKMALHYYARWKFIHGLIPALVTAKEAGEDAKVFSVLAAGKGGKVDLDDLGLKKTFSLSAAALQVTTYNDLMIEEYASRYHSLSFIHAYPGWVRTNIGSASPSPIIRVATKLATSRLSPLSYLATTQDDAGEYLLHGLLNTVSSPGAWRIGEHGDDIGKTRYFGDEESRKKLWEHTVQATGSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLV1</accession>
    <name>A0AA38NLV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_356248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793357">
        <property type="protein sequence ID" value="KAJ3784984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="151" mass="17123" checksum="C9B695301665B652" modified="2024-01-24" version="1">MAQPQPVSLTDLDLTQLGEIKKQFEEELNHLTNSFAQLKQAQAKFKACIENVAEINLQNQGKTILVPLTNSLYVPGKLNDPEQVLVDVGTGYFVQKTRPQATKHYQNKVNYIQTNLETLEDTIQKKRDNMNAVVNVIQVKLQEQTRNTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM44</accession>
    <name>A0AA38NM44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_268944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793337">
        <property type="protein sequence ID" value="KAJ3785599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM44"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="258" mass="28670" checksum="68E8D7910E8FC0C4" modified="2024-01-24" version="1" fragment="single">KFLLGLTTFMYTVTTMYMAASIANMIQLIQSLFFGFSTRNVINIQIFNALFLVNYGLTDGVVVWRAWVLCRYDHRTALLTSVFFLCCALLSEMSTIAVRVTLSCLPPSDENAFLSLSRVINITQVSNLGLSLLTNLTATGTISFKAWSVTMRLRKMFFTVPSRPRTGKIMVLIVESGVLYSISLITILIATLIPLPKGTLGDLYTPVNLQLAGMYPLIVLIMVNKNRTLDKVVSVFSDNHETHSIGNFTTAIDTEQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN02</accession>
    <name>A0AA38NN02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_331144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN02"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="222" mass="26140" checksum="AD1871042907671C" modified="2024-01-24" version="1">MAERYLSPWVSDDEQSLAATFRAAKELVKKRKATEQRKKLAEERRKNEEEERRRKEEEMRRTHEEVEQRWSHIQAARKEREEWEACQREREAKRQRLRELLASIESGTTRAGAMEVRDEIQSPQIRNKRKRGPESITSPDPGNVVDPQGLKNKTPCNRKKLSCSYNADRVKTTRNADSQCGLRYQEVNEKLLVMNRQVMETMCLVKKMREEIGEVSRVIRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNN7</accession>
    <name>A0AA38NNN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_410219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNN7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="44"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="590"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="872" mass="99494" checksum="B88AA00A3C28CE31" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNP7</accession>
    <name>A0AA38NNP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_345297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="186" mass="20617" checksum="B7FCDEAF1B464E0C" modified="2024-01-24" version="1" fragment="single">MMLNLRASAYTLGRRLSNYNAARLHAPVIPLERTLQVPHRFQLSTSTANFSSISPAPNGSDAGDRPLCREDFVLPDHVKVALDKGTMFVFAEASDLKEVPLTDSIKESGVIPSGYSIDFIVSPERIISVLNQVGIKTIGQLPEETYHEMRATINNPSNLSIIPTSVYEIKCQLQAQTDRESEEQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP31</accession>
    <name>A0AA38NP31_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_73318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793455">
        <property type="protein sequence ID" value="KAJ3782765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP31"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="265" mass="29891" checksum="A2A8F98BD4109658" modified="2024-01-24" version="1">MTEYDYSPEGYQRYLDTQRRISKWVQNTNAHASEFRSPFGIRSEVSSGVGTSTTSSKSKPRGDRILAEEGRRSRTDDRGRRNSMSDTTMRQSGSNAATFQRLPAYTSQLRHSYPYSPASREIHATDRTTTHHSHRRAQSLVPRSSQYQSQAQSQARTHHHTSSHRTAHGLDSPRRSSTLPAYVVESPQQSTNTTSYRTHRTHSPHRLSSSHSHHHSHHHHSRSQSTPRSSSKLSSPLAVSPVYVANPGTYVVIPPRGRKVSVVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPF6</accession>
    <name>A0AA38NPF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_388151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793369">
        <property type="protein sequence ID" value="KAJ3784640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="258"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="455" mass="48472" checksum="FC0F7A46209FA4B1" modified="2024-01-24" version="1">MSHSPEPTKAAEKETSSRAVSETEASTPSNNEVKESPANPPVMDFPEGGFAGWATVLGAFLVQFCGFGYSASFGVYQAYYTTVYISNESASTVSWIGGVNASMSIFIGLISGRLFDKGYFYHMVWGGAVLDIVCLWLLCLAKPDSFYQNFLAQGLGCGIAQGMMYLPCIAVVSHYFRQRRALAMTIVASGSSMGSIIQPIMLNNLLNTNGFKTAAVANAALLSGILVIACALMRTRLPPPPTLMPFKTAIIKFSKDGAYVMGCLGLIIFSIGYYYPLFYIQLDAEKHGLSSHINFYVLVILNVFSFLGRLSPGFLANKVGVPNLITMGMFGCSVVMLGMIGAKSVGSFIVIAILYGYCAGTFISLANPLLAGFATDQMEVGARMGIGFTLSGIGALVGGSIEGALLTSEYVWWKPAVFSGVFALAGVALMVIMLIMIHQRKKAKAAAATNASEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPV1</accession>
    <name>A0AA38NPV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_386335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="771" mass="86192" checksum="305B3D6C4ECA5B62" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ25</accession>
    <name>A0AA38NQ25_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_308124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ25"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="191" mass="22064" checksum="617432472FD9F9D6" modified="2024-01-24" version="1">MSSPTQSEASNPIQAFFERYGSFDYDPAGETMPQFWKLCDLYNWDRDSDEREEALTEIRDAIAQQFNAFYGSDAECLNGWHSLYRALQIADIPDTVQGCKDMIKTIHVNICDLVDHKEDVPQKHSTEDELADYSRRTGKIYPRENAYAGGLLRFLLRQITGEYHGKRCDRGQQRGGRKGRQGSKRHRRGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ94</accession>
    <name>A0AA38NQ94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_306004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="545"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1394" mass="150699" checksum="D6047701C7CEC6EB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQQ3</accession>
    <name>A0AA38NQQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_54143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="767" mass="80047" checksum="41693E02DEF36A6B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQV4</accession>
    <name>A0AA38NQV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_48732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="108" mass="12376" checksum="91C7206A17F98A43" modified="2024-01-24" version="1">MQPHRLSYNSVLKQRSRPPTRAKVGPSRREAQYLDPFYRLGVDPLKQAMNPAMLIPFVSEMGKVYGRNVTGLTKKNQRKVGKAIRRAKMMGILPILSKRNIFQPSRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR21</accession>
    <name>A0AA38NR21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fet3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_343116</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR21"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041377122" evidence="9">
        <location>
            <begin position="21"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="155"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="410"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="632" mass="68369" checksum="5EFCCC20C36E4D7B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR69</accession>
    <name>A0AA38NR69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_342858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR69"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 32 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="696" mass="79953" checksum="A634AD10C0F70AEE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR83</accession>
    <name>A0AA38NR83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_260287</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000021">
        <property type="entry name" value="DIS3-like exonuclease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="16">
        <location>
            <begin position="76"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="17">
        <location>
            <begin position="520"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="328"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3789635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112057" checksum="6B234248ECE56A37" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRM0</accession>
    <name>A0AA38NRM0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_425426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRM0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="205" mass="22827" checksum="F156D35A9DE01C13" modified="2024-01-24" version="1">MQVPTSLNQACTLCGNPCAMWCSRCQNTWYCCPEHLQTDWPRHRRDCIPASQNTTSGYNSNMIATPPPAEPQYITVTAILFAPEADRWTTTQVHCRPTPRSSHGICPIPILQMFFPDGLTEGIVLTQGLNGENLRFPLHLWYSPTALQRSSPVNRSIYNITCGSASKAWCGPVVVLKFNGSRRQGYTDASPNDLPALSAYFLAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRS4</accession>
    <name>A0AA38NRS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_341793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041253301" description="Sphingomyelin phosphodiesterase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="228"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="250"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="645"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="677" mass="73702" checksum="5710E77F13FFEB69" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRY9</accession>
    <name>A0AA38NRY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_304042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRY9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="580"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="836" mass="92147" checksum="8D7D44F1B81D68E3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS61</accession>
    <name>A0AA38NS61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="5">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_282743</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="5"/>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS61"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3790164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="555" mass="62829" checksum="E7AE3D4F88B91B5E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSH2</accession>
    <name>A0AA38NSH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_340984</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="55"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="581"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="785" mass="85065" checksum="F60F7B575E0A4567" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSH7</accession>
    <name>A0AA38NSH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_341057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="79"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="20696" checksum="EADB3D07294FA04D" modified="2024-01-24" version="1">MSMLRVSTMRAFRGAPVNGLRIAAPGIQVVQSPHIVRFNSTEPKPKPRPVPKEKDFNPVRDWDAKVIRYDELKPKTKSPAPNSWLIDVREPDEVMQGMIPSAVNIPLTILPESLNASPATFREKFGFEKPERNQEVTFYCRSGKRSSSASDIAKRNGYTHILNYEGSWLDWVEREAKAQGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSS6</accession>
    <name>A0AA38NSS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60s acidic ribosomal protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_340859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSS6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="111" mass="11401" checksum="F8279D91D3908EC0" modified="2024-01-24" version="1">MRYIAAYLLLQIGGNSSPSASDIKKVLSAVGIEAEQERLDKLLSELSDKDINQLIAEGSSKLSSVPSGGGAVAASGAAPAAGGAAPAAEKEEEKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSW3</accession>
    <name>A0AA38NSW3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_258353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSW3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="15"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="20099" checksum="76D2763F9AAB322F" modified="2024-01-24" version="1">MAASPDDIMSWTNQDPRESQLFNSWGILYRFQTTVSANGTSVTTLYRTIRANKEDRVAKLEWASNGGLGRVVIGKNTLPMSDLVRPDPHIYGSRIFNGPDGLTYRWRPGSNGDILLQDANGNVLAFYRTTRQTRYQIGDVFGELHFIRSAGSGTVMHPPIMDMVTVTAMLYRFCALFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU68</accession>
    <name>A0AA38NU68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="261" mass="28490" checksum="BFA1FE807089959A" modified="2024-01-24" version="1">MSLCEDCIKGVRHEGTSEGKWETINGVESYIGTPSDEYNKSKVLLFLSDAFGPRLSNAQLLVDDFARNGIKTVAPDLFEKDGVPADLFESDEKRKAFDIASWLARHSFTVTRLLLDKVIAGLKDQGVTEFAAVGYCYGGRLVFDLAIENIITVSIGSHPSGLKAPDDLEKYFSISRAPLLLNTCTVDEQFPPSAQSQTDAIFGGGKFAPGYKREYFDGCTHGFAVRGDMSNPKIKAGKEGAFGATVEWLYRYGFGPSGQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZE3</accession>
    <name>A0AA38TZE3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actinin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_284889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZE3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="128"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="626" mass="71537" checksum="666786B99DABD9F2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA56</accession>
    <name>A0AA38KA56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Emopamil-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_291948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793338">
        <property type="protein sequence ID" value="KAJ3785544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA56"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23776" checksum="354D73FF582C0725" modified="2024-01-24" version="1">MQLCRAFPARSQLPPSRSSSGIINQPWTMAVKTYTWISLWFLLTTPIILWDVGYCFMRPRSMIGGDLHWIWEPYGIYQNVDLLYGIPALEEGNGFTNAQSLMNIFETILNLTYLYLAHISSWPPATLIGFGSASLTLSKTILYWAQEYFCGYCAVGQNDMKSLIVYWIIPNGLWLLFPFLIIYTLGKDLCAQLMFADRSAAALVEGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAN0</accession>
    <name>A0AA38KAN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_168595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36578" checksum="BDE58FEE2B68AC37" modified="2024-01-24" version="1">MLAQMLFMQPPVPALPTSLNFHGKTVLVTGANSGLGRAACLHYLQRNVSTLIITVRRASEGEAVKAELLAHPDVKDEPKILVFELDLSSHSSVIAFASKLRAEVDCLHIALLNAGVFLLDWKVSPHTQNEMTFQVNYLSNAILSLLLLPLLRATAEANSLLAPSYLSIVASQKYNESRFIANPIPESTTIIDAFNDEKGFQPWSLYADSKLLVRLFVKELAKHVDPSTVIINCMCPGMVKTNLARNLSFPLRLAGRLVLSVRARSPEVGSRVLVNAAGGAGKESHGEMLVVYQVLPGIPWIESKEGERMQTNLWRETVEEAEKNASGTIVAASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBN0</accession>
    <name>A0AA38KBN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Needs CLA4 to survive protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UBA4</name>
        <name evidence="15" type="ORF">GGU10DRAFT_125839</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004281">
        <property type="entry name" value="PRK05690.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="303"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="13">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3788064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="401" mass="43728" checksum="7BE880A178216652" modified="2024-01-24" version="1">MAETPLSLNDYRRYGRQMILDGFGLPGQLKLCNASVVVVGAGGLGCPALQYLGSSGIGRIGIIDHDRVELSNLQRQVLHNEETVGMPKAQSAAIALKRINSNLKIDVIIKALTPENALSLLEPFDVILDCTDNAPTRYLLSDTAVALGKPLVSGAAQKFEGQLCVYNLGETGPCYRCLFPKPPAPENAGSCEETGILGVVTGIIGNLQALETIKILTDLQDYKPTLLLFSALNTPQFRSIKLRSRKPTCPACGREGQKLGTISEIDYVQFCGGATPDWESLGLVETHPEHRIRVKDLKNSMDADKTLHLIDVRPKTEFEICHLPRSNHVPLSDIVANPTSFLPPHPNTPTYIICRLGNDSQIAAEALRGLKENDSQNMIVKDVIGGLRAWSKEVDPRFPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBW8</accession>
    <name>A0AA38KBW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_346132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041230754" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="189" mass="20658" checksum="5FB49C9C6BDA70A1" modified="2024-01-24" version="1">MIQFRACIFFVLLVGVTIVSAVPTFDGQYSIGALIPGLSSLQALREGHSRKSAPRHLNVRPPNVVGNLTITTGAAGVPLFYIHRSRLWRYINETSIHAVNIVNGTEEAPGTNQIPLQMMLEEKPGGIDGGVWKWKGTMLIYQLGKFNNSGVYYDCMLPKGGHGLLTFLEGVPTPRGCSLLTLHGFEHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC67</accession>
    <name>A0AA38KC67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_306161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC67"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="104"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="368" mass="39338" checksum="48C4785CA484DF3E" modified="2024-01-24" version="1">MSYNGVDRKDRVPSPSSSHRNVVDHDSPNVTEEPTGATTKMPQAGPPKSHMIQVQPLKRSEMQPSYAQDLGTGEVTHGIYGSLLQGLGSLVGFCGMIPCCPCPNPFRNVQQGSVGLVSRFGQFYKSVDPGLVQVNVCTESLRIVDVKIQISPIGRQTVITRDNVNVEIDSVIYFQICNPYRAAFGITDLRQALIERAQTTLRHVVGARAVQSVVTEREAIAFEIAEIVGDIADKWGVAIEGILIKDIIFSPEVSASLSSAAQQKRIGESKVIAARAEVDSARLMRQAADILASPAAMQIRQLEALQQMAKSGNSKVIFVPMQLQSDVVNQLASGSGSGTGMGAMIENETGDSLGGAGKVGLLNSMADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCR9</accession>
    <name>A0AA38KCR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794481">
        <property type="protein sequence ID" value="KAJ3779636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCR9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="34122" checksum="0AD003F40514E550" modified="2024-01-24" version="1">MGPYIVPLRYRKTGKRVDDREHAKQAFDIDNNLEGVTDDLRRTFRVVYKKHGSLKDRRDLNIKYRHVGCEQCISRNKPCEIRATALQCGNCPPYVKCTRVPVLKRLRVLDIMDITEQQYDCLLAWYKKTADEELLGPLRESFKIPSARVESSSSSGHEPVSPENISPHSFLVPLKAASQDHDEYSVPCKLTTNSLAPPPSPSIPASHAQEEQWPREEIVSPMTPYYTLPSPYQSPSPRLLAPTASYRIPDSFVRGYDEDSFSACVVPNAQPYEPLDYIRQALGTAAMTFVATQQRADNNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCY9</accession>
    <name>A0AA38KCY9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794024">
        <property type="protein sequence ID" value="KAJ3779966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCY9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="139" mass="15642" checksum="0F238D163C21DD21" modified="2024-01-24" version="1">MIARGGHHSDPDDDFEPEQDGLNPPPLLLLIPRKVVRRVPGVYQLVDHWSVTPNLCNDKRRLAYWSGDNTSRRSRGKRVKLDHEVYEGPTAQVGERRFEGPGTAEQLAAIAGQNKDLIDIARCSLVLQERILPLLVRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KED5</accession>
    <name>A0AA38KED5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793351">
        <property type="protein sequence ID" value="KAJ3785173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KED5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="212" mass="22693" checksum="3E7FBC14766E7904" modified="2024-01-24" version="1">MLEADSRSTICFPDDGDVELGPYRKSFSGRDSSDVPLSPCSSTSTYALSPATPTSAPPSYTDVAPANTPASPLSEIGRNLHPLSSAPSVMTLDSVTEMAGVSSQRSSLSLFMNSNREQNDGECRQEEDEIFISDAFVDSRPTSPVHPLRVPTPIPFISSDLLASPPPVPDLYRPFSLPSVYPIVQPHSAREVQANVGMIVAVQTQSSREALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KET4</accession>
    <name>A0AA38KET4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_291553</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="785"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1350"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3785758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1373" mass="149229" checksum="517C270264490F2D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF45</accession>
    <name>A0AA38KF45_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_273265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793413">
        <property type="protein sequence ID" value="KAJ3783566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF45"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="210" mass="23420" checksum="EA9CA4FC5FA7C210" modified="2024-01-24" version="1" fragment="single">ATEGGTNPFTTFHFSMWSRYSTSGKDAPSDVHPYHLQAAMGTKTNTSQFFVRPSSDIQDFSKEYKELYDIFGDVLRLMVTTVRSEFPEELKDVMANVDIFPLNDSSPISPFTSFVLNINVETGAHRDDGDCGLCLILALGHHTGGELCLYEPRIMLNLVHGDWVAFDSKSITHFNMKYTGIRCSAVIHSDKTGIAHQKDGNGWDGNNYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFA5</accession>
    <name>A0AA38KFA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prenylcysteine lyase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_352031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041338129" evidence="8">
        <location>
            <begin position="16"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="149"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="513" mass="57357" checksum="2A64DDC2B28551CA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH57</accession>
    <name>A0AA38KH57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HRDC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_161917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH57"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="134" mass="15035" checksum="473FD64937211F85" modified="2024-01-24" version="1">MATRLRHRPTGEEEDAAALKLGPEFNNAGCLLISEVKYLLENRDKDAPDTAVYNKTLEYVKTFTKFSTTDSASAVRETLRREPALTQFETAQIANLCPADAEEAKSVIPSLVKIDDDRLQALLDEIQTMRKFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI42</accession>
    <name>A0AA38KI42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_306111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="176"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="545"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="792" mass="89562" checksum="4D00C8EC73F8BFCC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI68</accession>
    <name>A0AA38KI68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">GGU10DRAFT_305928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="199"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="506"/>
            <end position="507"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="515"/>
            <end position="519"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="591" mass="67464" checksum="ED2CE358310F2C47" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL06</accession>
    <name>A0AA38KL06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_300282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793616">
        <property type="protein sequence ID" value="KAJ3781004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL06"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30944" checksum="E730EC50212ED9C9" modified="2024-01-24" version="1">MSSDSENINYAMAFGFNSVPAAAIFAGLYTPLFCFFLFKIIRERRGILITLLAFCLFRIVGFVMRAIAASNTTIGQNAGYVVATQTFFSVGFFGLLFCAYLLVVARFELCTTKPSSSPFIRALQRIIRQPWAFRVCMTAPMALGIAGLDESVEHPEDNLGVNLRKASAVLFLVLTLFQVIQTGALIKAEHEDRDSLKYTSPSFGGRHASWIFGCISILLLIREIFTTATINSFSKANNEHFWYPLVAVPELLCVILYLIPGVVPPKIKDKSEPSDVVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLM7</accession>
    <name>A0AA38KLM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_390288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793517">
        <property type="protein sequence ID" value="KAJ3781874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041392036" evidence="2">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="380" mass="39323" checksum="0B6DF8A05A85B8AA" modified="2024-01-24" version="1">MARLLTLVSLLFFSVGSRVAASPCVAFDASWNLYAFGFNDKDYNAGTSDSWASGTASDITASGRPPFDGSNTTCYLSQFYNAIYVLNGDSSNPSNVHVFDPTAKSWTTQVTSGGPTDGYSAVLDHDTNVFYVLSDSGELWFLSFENITTAAQSSTIAWTDVEKAGFDTTNYQPVMALANNHVHFLNVPGVAAGSADIFVIHFSWFQPDPQSYGNFPAQHGQTTSIFEPANDGVQLAFAYIPDDGSATYVIDVVSNTTTSMAGPSTKDSSAIYFASDAAIVQLTSSGAVNYIPYTNSSSDSSASWSSVKNLVSVAPTSSASSASGTATKSASGSAASGTSTSSSSSSSTSNGASSMAAQSGSVVAGMMSALLLGTIAVFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLP9</accession>
    <name>A0AA38KLP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNase I-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_278073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793594">
        <property type="protein sequence ID" value="KAJ3781155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLP9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14642" checksum="D7C3B9A911FB41F9" modified="2024-01-24" version="1" fragment="single">MDQQPGNAPAKSLKIWQQNLNKSAQAQFSMVFNTDKSYDILALQEPNIDKYGNTKSISRFYSIYPATHLDSKTMKKKTRSVILVSTHLSTGSWTAIPVRHPDITAIQLTGTYGTLRIFNLYVDGHHDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLR5</accession>
    <name>A0AA38KLR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793585">
        <property type="protein sequence ID" value="KAJ3781230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLR5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="472" mass="51143" checksum="15D7A9531EC9E704" modified="2024-01-24" version="1">MPFPFPFTFSLTVPGLANPFSASPLYPYQQSLRTQSEAGSSTMRTGRRSNLDEHGNEDELNLSKHHPKSRRASPSPVELGSSRKRGWEPAFAGEPSLAPTFVTVSNGYLDTPAKLGKQNGLNAHEQAVEELQHPPAKRRRTLAGSIVSTAVNAALVGTAVGLTVYRLWRDRGIGKHMEQQITGEASPSPPPPPYTPSSPDVNVIPPTPRTTRKSRRTHDAHSTRRRPARKVVHNISSLGASTSTSQSALFPPVQPAFDFSPSSQPSPSTSSQRNQNRQTHSPAFGLGPSSDQIEGIDPRDGRDLDVDDQMDQMDSLGSKLSLLIEQGKRALGREVVVMSEVEEDAVDDGSGAWIEEEEEGEFGRKDRTHRGRLSRSGSTSKRRTAGSVSASSTTGSLGRRAGVGMNMNINPPPYGMGTDMSLSSSLPSTPPASLPTCETSWESPELRETMERARAIVKERKSMIFRTDTGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM26</accession>
    <name>A0AA38KM26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_97890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="MU793530">
        <property type="protein sequence ID" value="KAJ3781725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="110"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="247" mass="28138" checksum="FC15C6942688A376" modified="2024-01-24" version="1">MVLKLYSHGISTSAQRVICVLVEKKVPFEIIEVDIVKGEHKEPAYKEMQPWGLLPVLVSYFIRCVQVKRNTEPAQEEENGFRLYESRAICRYIAEKYADQGTQLVPDPTDLEARGLFEQGLAMEAGTVDPCVFAALNEKLFKPFKTGASCDDELYVVLLKRVELVLDVYEVILGKQRYIGGNQYSLADIYHLPNGFALQTQCDEQVFLSEKRPNVARWWSEITGRDAWKQVGELNKPGMHTLESKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMI9</accession>
    <name>A0AA38KMI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794248">
        <property type="protein sequence ID" value="KAJ3779766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="99" mass="11426" checksum="48CECDF8F33BF7B1" modified="2024-01-24" version="1">MFVLGIVSRDGIHQTAARSWWPRPGAWRSCGLNCGYWSRDAESWFQNRLNLIRAPGQSSALMTIPEWHSRLKFHKAHTLSKKNEELALEYIKQKCGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNJ3</accession>
    <name>A0AA38KNJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_358518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793385">
        <property type="protein sequence ID" value="KAJ3784229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNJ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="288" mass="32665" checksum="A997E55FC16954B8" modified="2024-01-24" version="1">MIPETYTRTIEADRVHVFYREAGRTNTPVVLLLHGFPSSSFQYRNLITRLAGRYRVVAPDLPGFGFTKVPESRKYRYTFDNIAKTIEAFVDVLGLEKYAIYIFDYGAPTGLRLALSRPSAITAIISQNGNAFEAGLGKFWEGIRKYWKEPTPANRQSLVWLTEFNTTKSQYEAGETHPETLPPETYHLDQALMDRPGNADIQLDLCLDYQANVALYPSFHDYFRKYQPPLLAIWGKNDSIFIPDGAEAFKTVLPKAKVHFVNGGHFALENHLDEIASEMIGFLETNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP00</accession>
    <name>A0AA38KP00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MutL C terminal dimerization domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_272621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="2">
        <location>
            <begin position="175"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="398" mass="44918" checksum="9A9DB3FBAAAD12B4" modified="2024-01-24" version="1">MVVDTSDDLFAPNGISRNISTSSSVSISTRITTPPASSSILDSNISVSDKPSELDDLILDKDDDKPSLLPSEDSNLHQTQNEPIHRPEVIRTEASRSSAGDIRLRFDVFKLTERWTTLHANLREATVRRELGEQEDQVASSSLAEDAGVSAVDAKTSEAALSRVISKKDFKEMEVLGQFNLGFIIVRRRKKRAIEEEIEVEHTIGTLDDLFIVDQHAADEKYNFETLQQTTNIKSQRLKFRARPLELTASDELVALENLDVLKLNGFELEVDDDDHHNQTHRKLRLIAQPVSKSTVFDMRDLEELIQLLHDRSTGQTIRCSKARAMFAMRACRKSVMIGMPLTQSQMSTVVTHMGTMDQPWNCPHGRPTMRHLFDMANLPPSTQNNHASRKIDWATFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP14</accession>
    <name>A0AA38KP14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Folate-sensitive fragile site protein Fra10Ac1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793569">
        <property type="protein sequence ID" value="KAJ3781356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP14"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="246" mass="28823" checksum="A604C22F828A5B13" modified="2024-01-24" version="1">MASYSYTSYSKSLTIPQGKTEFEILKDSHKFLRNEEDDENQLSWEEKLASKYYSSLYREFAVCDLKHYKSGNFALRWRTEDEVLAETGESTCGNTRCKHYNHGRPEGDKPPLSTLELPFAYSEHGENKSALVKVVLCARCVDKLMWKRRRGKDEGPRAEADQPHQESERAKVKEEEFELDVLESDGKDPSKSHRVNESSGRHTRIDRWDKEDKERKTDWNKARRSRSHSRSRSPQPHAARKRFKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQF2</accession>
    <name>A0AA38KQF2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_171855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793313">
        <property type="protein sequence ID" value="KAJ3786479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQF2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="480" mass="45763" checksum="7417D2AC31F85D37" modified="2024-01-24" version="1">MLLSFGPLLPKNRGFLVAILTLIDLFVLDIKTSQVDFSFFPFVPTTSFSHIVSFFSFFSLRSTASSVRSCSFPSHLLACILSFVKQSVVILLSSHVYEMLFKYSLLVLLACATTSVVAAPLAADSTLELRHHKHAKAAANGAGANANAGTGAAAAAAGTTAAGTTGTNTTAAGTTAAGTTGTNTTAAGTTDAGTTGTNTTAAGTTAAGTTGTNTTAAGTTTGTGATGATTNSTAAGTTTSATGATTNSTAAGTTTSATGATTNSTAAGTTATGTAANATDAGTTTTGATTTNSTTAGTTATGATANSTTADSTGTSTTGTTDNSTTADATGATTNSTTTTGNVAKAKHHHKGAAAAGAGTAAGAAAGTTGTTATTGTTNSTTTTATTAAGTTTNSTTGTTDATGATGTNSTTAATGSTATAANSTAAGTTGTADTAGAIAGTTTAADSTTADSTTALKIRALKDINARRALALFEFNEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQL1</accession>
    <name>A0AA38KQL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_354099</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQL1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3785700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="356" mass="38128" checksum="426D298ACE77A9D2" modified="2024-01-24" version="1">MLSAARLSLLRRTFTTNSVNGFTGAVGNTPLIYLKGLSERTGAHIYGKAEFQNPGGSVKDRAALGVIRDAENRGLLKPGGTVVEGTAGNTGIGLAHVCRARGYRCVIFMPNTQSQEKIDLLRMLGAEVYPVPAVAYENPANYNHQARDFAKDLPNAIWTDQFDNTANANAHYESTGPEIWEQTKGEVDGFICATGTGGTLAGVGKYLREKSQGKTQIWLADPPGSVLTSYITSGGKLVERSGSSITEGIGQGRITNNLGTFVNQLSGAFTVDDTKSIEMVYHLLDTEGLYLGASSALNVVAAAELAVKLGKGSKVVTILCDGAYRYQSRLFSKQWLKTKGLEDAIPSHLKKYAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR29</accession>
    <name>A0AA38KR29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose receptor Git3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_349188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51703" checksum="432B5F0F0547B4E0" modified="2024-01-24" version="1">MSNTTSLRLPNGEWLLTRVAYTSKEDSGVTFLLVVSILSLVAVIGLLAVISLSAFNTRSYKNEEHLFVRTHVGAYFISLLCCDLIQSIGSLYNSRWVSSGAVLLDKYCTAQAVFKQMADVGTALWTIVIAVHTFYLLVLERRPNRFTLFATLIAGWSGIFAIVISGPALLDTVDRGPFFGISGYWCWISDGYEVPRITLDYLIMFAAAFLCFVLHGLIHLRLRGNMSMKGWRMTFRKQAQERPLDRHYDDKGVTIARQMLLFPIAYCIIILPIAVSRFAAWNGHIVSFEETVFCETVFLLSGCVNVTLFCTCRQILPPQSVVLLKRSISKPKPMERVEASSDAVSPESDPYYASSITTTVVGYGFDKTSQQGHDVDLEKGTTSSTMSVAMSEGSSGVSVPHEHIAAPLQIRKSVRHPRPPSVIIPSREFDDVYDTYSGGQPDVRSGDFNDVNLESNGRSGPHPSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSX1</accession>
    <name>A0AA38KSX1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_381664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794149">
        <property type="protein sequence ID" value="KAJ3779847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="55339" checksum="E4D7D477A3D38996" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUC4</accession>
    <name>A0AA38KUC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Replication protein A subunit RPA32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_319543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793515">
        <property type="protein sequence ID" value="KAJ3781902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUC4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="7">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="8">
        <location>
            <begin position="165"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="267" mass="28900" checksum="B3786DDC2792955F" modified="2024-01-24" version="1">MSQGGGFYQNSSPFNQSQASPGGASEAKRTELSHSVRPLTLAQVNKAHQAHTDAEWTLEGSEVGQVTIIGHVVNISEQTTNFLYTLEDGTGKVEARRWREQNSEEDADKWGDIQVNQVIRVTGHMKAFGSRKYVNAVNIRPSEDPHEIYFHMIEALTVTLSLQNGAPGGTVGQKSPGTASAYTAQSSGIANDDMAEYKHLPPLQREIIKVLLSQPEHDEGGVHVGVVAKAVQKQGMTSASISDALDALMDAGQIYTTSDDAHFQVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUW9</accession>
    <name>A0AA38KUW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_389505</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="MU793447">
        <property type="protein sequence ID" value="KAJ3782892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041372380" description="Probable beta-glucosidase G" evidence="18">
        <location>
            <begin position="20"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="721"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3782892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="802" mass="85635" checksum="06C21AA27A1ED2DD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVR0</accession>
    <name>A0AA38KVR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_22670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793368">
        <property type="protein sequence ID" value="KAJ3784647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="613" mass="69864" checksum="2B944F38C7A6A460" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVX2</accession>
    <name>A0AA38KVX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_356256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793358">
        <property type="protein sequence ID" value="KAJ3784932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVX2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="207" mass="23714" checksum="547EFF9EBA54783E" modified="2024-01-24" version="1">MLHGFSTDDDSSDEEIDGPPVDITKLPTIAKDDATVHKRLEKAKKQPATDRGVLYLGRLPHGFYEDQLKGYFSQFGNITRLRVSRNKKTGKSKHYAFLEFDSSSVAQIVAETMDNYLLMGHILRCKVIPKDEVHPELWIGANRKLRVVPRHRVARATHNKPRTSEQQARATERLLKRQNDKKRKLKELGISYNFDDVAYRKPLSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWP7</accession>
    <name>A0AA38KWP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793676">
        <property type="protein sequence ID" value="KAJ3780668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="411" mass="46148" checksum="6C01A380A49153F9" modified="2024-01-24" version="1">MPSKSTPETVITSIPSPEAVVISTFASPRPAPPPIVVPLFASTVQLRCHAVLALHENLDPKPRSYHPYPQTKRPVPSNVPVPGSPLTPITPGHPVDAGGRQTEPRLILVPPPHGTLTVPKLGLAEAVARDYRLIAKKVILDLAMDIHQSLTDQDSQSKNAARARIEHEIPHLKLHEDHWGADILLRDQLKSMKDVANKVSRRERRKNNEGSDVSNQSNPYLPSNYKNTSPICLRLPARSFPTLIPNTRSPLFYANSKMPRTSYTVCKTSKLTLLLIRAYFISTLDHCGTFIPLPTAAPNSKHDSLRRPHVDYWLPPVSQAYVHRVITHFHGERFAIYFQRYHTLPENTSLNFRGNLVITRMGSKNPLNPVNMKAGKRSDARKARAIVKKFAPLLAWFQADHERELPDDIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX80</accession>
    <name>A0AA38KX80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Indole-diterpene biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_288758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35714" checksum="97BB2066FCF81CED" modified="2024-01-24" version="1">MSMAGVSNSQMSLSATLKRAGLAPIGKGIYLSNRTREASGSSSAASNPSKTPNIILVFGWMGANLPHIFKYTKVYQEMYPDATQIIVQSRPQFFWSSNRTRMNNLVPVAEVLEAHGCSGTKLEVAPASESDPPRILVHSFSNGGGIQMYTLGKLLRARSKSSSDFCGHKPRMSAMIIDSCPANATLRGALRAFTASLPKNSPLRIPLIIFIILIYSFNSFKHRIFGVQPIFERLKRGLLRQGPEGGILPWMTEKTPRMYVCSKQDELVPFEEIEEHVKEAKARGLNASIEIYDDTPHVAHARRYPERYWGAVKDLWAAAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXR0</accession>
    <name>A0AA38KXR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_363956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU793478">
        <property type="protein sequence ID" value="KAJ3782408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000046">
        <property type="entry name" value="Geranyl-CoA carboxylase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="304"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3782408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="559" mass="60228" checksum="F7D14505A78E032E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYA5</accession>
    <name>A0AA38KYA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_274124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793434">
        <property type="protein sequence ID" value="KAJ3783143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="153" mass="18156" checksum="691C88BF51DF5066" modified="2024-01-24" version="1">MLRPLNSLLRRWHRMLGLQRQSPPSWYKDRLREELRERRSAKTSLHKLSETSDVFFAIIRANYDGFNVRKIPPFVASRHSLVYAYMLGKYTLRWGFYRTAAILCKAPRCGSVREVVNPGKDSKLHEVALRHQIDPEKFKRVGRKLRRVWPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYF3</accession>
    <name>A0AA38KYF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-carboxy-cis,cis-mucoante lactonizing enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_392930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52164" checksum="487623045CD36165" modified="2024-01-24" version="1">MDIDMMVPVQQVYMSSLNVSSYPESLHILAGSFRSLSLFLLAFSPAKRTLSLVHQVPGYGPHQYVTTDQDKTRSLRRQADGKLDGSIAYTTSWAVPPILSSWEITPEWQINHLDNVPITAVSSYITLPPPYTHIYSMGGPTGEVHLRSPQTGSFAEKVQEVLFVPSDRLADADKSRKALRYGSHAIEFTHIPGTNTRLAFVPVLGTNSIEVYLHNPDSGYLTHVYSSPSPRHGVDDGPRHVKIHPNGKMLYCVTEHNNLLDVYSISEREQTNSTETESTWSTNPLTHLGTRSLLPPHLSYPNAPMKTVHRFRGDTLMLGPGAEEGQLPTEIWATTRGTTEADRGWISVFELDKAGMFIPSPSSNEILSAEEGVERYETPTSGGKAHAIDLYPKSVTSYSSPFTASNSTRTGSPVWILLTDDSDYAAGELREESSATETIKAGKPMGGVRVLEWDGWLSDGIREVWDSNPRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0B4</accession>
    <name>A0AA38L0B4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phytase A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Histidine acid phosphatase phyA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Myo-inositol hexakisphosphate phosphohydrolase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Myo-inositol-hexaphosphate 3-phosphohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_137091</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77131"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84142"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0B4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041448140" description="Phytase A" evidence="18">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="75"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3787733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="469" mass="51711" checksum="206C9372D20C711A" modified="2024-01-24" version="1">MLPNILYVLSLTVLPILRVVSGLGGSVYANNQLTLQLEDETPERRTSQTHILQRNWGAYSPYYPVAEYVPPPEGCEITQASSLQRHGARYPTAGPAAAIALAVTKLQNVSTFKEPSLEFIRNFTWNLGTSDLVLFGAAQSLAAGAEAYHRYNDLVSSDNIPFVRASGSERVIMSATNWTYGFSAAGGMRFNPILSVILNESANNTLHNFCPSIGSSNAQTDIWIGIYTKPIVQRLNDAAPGAKLTVNDVYYLMALCAFESVATNMISDWCGLFDEDEWKGFEYEMDLDKYYGTGYGQLLGPVEGVGYINELIARLTSRPVNDTTQTNTTLDQSLTTFPLNRTIYADFSHDDQLVAIYSAMGLFKQPMALDPTSPLDLELLGNGLDKENTKRTWIASHLVPFSARMVVEKMQCRQLSSEDYMRILVNDAVQPLEFCSGVTPEGVCRVSAFVESQGYATSGGNGDWQKCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0W9</accession>
    <name>A0AA38L0W9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_285099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0W9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="633" mass="71130" checksum="633F2E473261DE32" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1G4</accession>
    <name>A0AA38L1G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_37817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794738">
        <property type="protein sequence ID" value="KAJ3779512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1G4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3779512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="427" mass="47441" checksum="CF03C5B6BCE2195C" modified="2024-01-24" version="1" fragment="single">MSRTNTYGNQNARQPRIGFVPPSPSNDDSFAEDKTTADVLITKAMNMKLLRTGEDPATTLPVQLIRLAAEASDGTSTARKANWEKVALIGKILQEASWKDTTKELQKDVTVAITAATENSNATMKRMIAEMRDEAKEITDRLAEATKGINEAIAEAGKTIEQAKQKGNGIEEGEIAPTNIPSYAQATRNKNGPRPTYGRRPEAAITAAAITERRFYVKSESESIWTLTEAQLAKKANLTIEKILMEEGEDKEAVKVIAVMKLRGKGAFCVLRNADEMLWMEEGERLKKFATDWGANATAQPTHHEVIAEFVPTTMDIEASWTWETITKNSQLPKNAIVAARWIRKPEQRKPGQKVAHAIFAFADMRVANRAIRGGLVVDHKMVNVRREEKDPQRCMKCQQYGHIARECKSNTDVCGRCEGTHPTQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3N1</accession>
    <name>A0AA38L3N1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_315922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793399">
        <property type="protein sequence ID" value="KAJ3783892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3N1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="5">
        <location>
            <begin position="47"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="204"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="452" mass="51083" checksum="EBDEC69347FDF024" modified="2024-01-24" version="1">MEPISIAMIADFFHPDVGGVEGHIYMLSANLIRMGHKVIVITHSRPPDRVGIRWLLPGLKVYYLPFVTIASGATLPNFFTFLPYLRTILIREHVHLIHAHASLSSLGHEGILHSHLMGVRTVFTDHSLFGFEDAASILTNKLLAGTLRNVDAVICVSHTGRENTVLRGELFEHSEDDPPRLVVSSNVYVIPNALVSKRFQPGLLQKSDTITIVVLSRLAYRKGIDLLVATAPRICAAFPNIRFLVGGDGPKLIDLLQMREKYLLQDRIELLGPIKHNDVRSVFIRGSIYMNTSLTESFGIAILEAACAGLYVVSTRVGGVPEILPEDMISFADPNEDDVFRAVSEAISLVSAGKHDPIKAHERVKRFYDWAQVAERTERVYHTVMKSEQRDLWDRITRTMRLGRYAGPIYSIILLVDCLFFLFLEWWMPREDMDFVTHHWNHRRFASATRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3Y2</accession>
    <name>A0AA38L3Y2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_335521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793474">
        <property type="protein sequence ID" value="KAJ3782470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3Y2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="332" mass="37918" checksum="D856AC6740C98FED" modified="2024-01-24" version="1">MTCPGRDPAGSCIFHSSPLAQEFDMFISYDHGKELLDPEVEAEAQRIAQEMPLSIKLASQIPNGFLTFKQYNCRGSPEQVAATWNKLSAQENQKWRRVTEIRKTLRARKIQESEKSTGQKSIAHRVESSHHEASEYRSTVFVVDQGKSFTVEDTLTFPDHNAVRRPVYNGSSPVRPHHVPKINPDIQRVFHAQRPIVNSNKPPAVRTSDEFAPSYVFTFNATASSSSFRPTEIRSDNRSSGFPTDSSWGAASFDSRHDYRPRIEPDDRLGVHRDFFTDSPSHRTYRPLPTPVYRESSYGSFRKRVVSTFPKKDGKDDALNRSEYFRTIFELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4B4</accession>
    <name>A0AA38L4B4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_274038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793432">
        <property type="protein sequence ID" value="KAJ3783190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4B4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="141" mass="15664" checksum="166CC094800DD907" modified="2024-01-24" version="1" fragment="single">QILSDVRAQLQRLKPTEAYEELREPEVGAPTFLVDIRPADQRDEEGGITGALVVERNALEWKFDPRSHSRLKIADRYDLRIIVFYGSDSSSLAAYSLQQLGLLNAPNIIGGYCAWRDAGLPVDIPIRSTRSVLSLPGESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4S9</accession>
    <name>A0AA38L4S9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_359097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="540"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="846"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="887"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="953"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1160"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1097"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1110"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1224"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1279"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1323"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1335" mass="144972" checksum="A4300EF4B3FCF2D1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4U1</accession>
    <name>A0AA38L4U1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_358827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4U1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041324672" description="Cupredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="21914" checksum="C692237923975DC8" modified="2024-01-24" version="1">MRFSVAAAALLSAAASVKAASFSVIVGFNDTLTFNPANLTGVADGDTVAFQFASKNHSVVQSTFAAPCTAAGVSSGFQNVSDPNGATFPTWTLTVENATAPLWFFCSQVTATSTHCQAGMVFAINPTAEKSFDAFQQAAIATNATSPAGQNPSGSIVTGTAGATDAALSVSGSTSAPTATAASGSSGTGTSAPASSSAANGASQLMSGKSISILAVAGLVAGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4Z2</accession>
    <name>A0AA38L4Z2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_352098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4Z2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="401" mass="44271" checksum="73FF690A969223A2" modified="2024-01-24" version="1">MASHSSSMEFIFLGTGTSSSIPHVDCLTQPPYDPNDPTSKPPCRTCLSTLTPGGKKNIRRNTSAVVRTKAQDGRDVTIVIDAGKTFQAAAVEWFPKHGLRNIDALLITHAHADAMNGLDDLRGWTLGESIQTHIDVYVSQGTFTEVQRSFPYLVSKEYASGGGDVPDFVWHIIDDKVPFEINDTGVWVTPFSVHHGRIFSPTPPPAYLPTPKGFTGGTATPVTPSEPLEQVLRSLFVNEAGSVQKKVDEIIQPYFCFGFKIQDEIIYLSDVSYIPEDAWSIIRDSKQRREGRPLPLCILDCLGLRSHTSHFGLEQSVATAREISAVRTYLLGFSHIVSHEEYVTITEAVGGAAKVKDEDALTEYERKGLQLIGSGEPFWIRPAHDGLRVIIDQGTVRDDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L545</accession>
    <name>A0AA38L545_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_20843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L545"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="453" mass="50288" checksum="824E687A9D266019" modified="2024-01-24" version="1">MMSADSALSHTSGTEPRHCFIPHIETCISFSLDVRRTLNLLRCEINDEIEIAIQNFPIRKYVAVVRTYENIPFPGCIYHRAGLRLLQQGTPESMTEVCFESLMCFPVAPETDLPLNHSPFRFNNPPLWDGSYHVSCMDRIVCIPRGHFDYADAFVMTMYSDDPSYEDTRVARAQQAKANGSSQTEDIVEDLCPSSPSVRKVVEEAESLDNSSRENRSIEPSSLLAQSAPRSDTKALRFYKDRNTVRLEEAFDELSDECFIGSESDADSQSAESWFSAEEGFSTDEGENNSLNDSHYIDDTIPLMNHISKVSTSFDGYNADGSIVPVVNFSLDLSGIPSLLSVDEYSKDYDMLDALVRKCRERSTPANVEEDDGEQSGSSLLCIEGALDFEQSTTSSTTSETSHTSLKETSNECVVSNTDLGASKQAKGSKPTLKSSRVGRFLLRVFSKLNTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L564</accession>
    <name>A0AA38L564_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_163753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L564"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF3">
        <property type="entry name" value="LIPASE LIH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041309132" evidence="2">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="114"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="326" mass="35816" checksum="7502F2277492F9CE" modified="2024-01-24" version="1">MSLKSTPFLKLVFIFTLLAHSTFAFPTLIPFHHSHDVSSQATTEVDNDFISSKLQRPAMFSRVVYCAKQNVTKWDCGGPCEAIGPDVHVVKWGGNDGLVPSYLIAHDGSTNTIVVAHQGTDSHNFLSELNDLDILHVGLDKSIFKQPAKKVEVHDGFQQAFKGSSKIILAEVKNALATFNSKAVLFTGHSKGATIAILDAIMLHEQLDSSIKQSVVVFGLPRMGNEHWANLVDTTIGTEFIRVSDRKDPVVDLPPRMMDYYHPSGEIHIVDVDKDGQATKVVACPGQENKHCAEGNSIFKEHVSDHSGPYFDDISFGQDACKMKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5G3</accession>
    <name>A0AA38L5G3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_265350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5G3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45167" checksum="1DBE57287494A39D" modified="2024-01-24" version="1" fragment="single">QHDLTHCTPTPADIRCFARLRFELTEIFANEAERRAALIDILQEENIIPPDADLNPSAVCPYTTDEDLRTTALGCYGDFLYFLKVIRNEIYTGNAEPYMEAIHYWWAHVRDQIDKQKPEVRDRLNYPAILLVHPGSHFSVAVAAFTDVMNVETLATIPLHVHSTNMSEVLAGERFIYALRTTLQRLHDFYGAANNLPPRQIEYPFRNYIVQNEAKLAFEYIRQVPDKRVFHASLEDGTPLFIKFSRRYGEVTHHAAHGAGLAPRLLSVENVHGWYVVAMEDLSKDYVTLAEISDDSYLSLLPEVHEAVCKLHALGHVHGDIRPVNILVKKPDVETVKPRIVFVDWDWSGESGKVCYPHSMNPEIQRSESAFAGAEIKPSHDLDMVSFCYNRDQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6C9</accession>
    <name>A0AA38L6C9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_349598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6C9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="278"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="450"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3787120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="736" mass="81874" checksum="E12DA6E55E700542" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6D4</accession>
    <name>A0AA38L6D4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanate hydratase</fullName>
            <shortName evidence="5">Cyanase</shortName>
            <ecNumber evidence="5">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cyn1</name>
        <name evidence="7" type="ORF">GGU10DRAFT_152062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="5"/>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6D4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048564">
        <property type="entry name" value="CYNS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002773">
        <property type="entry name" value="PRK02866.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21291">
        <property type="entry name" value="CYNS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="163" mass="17902" checksum="E9A38ACD2AEF86C6" modified="2024-01-24" version="1">MSQSASIPTNVAPFSALPSIHALLLEAKAKKGLTFDAIGKAIDKDEVWVASAFYGQAKFSAEELQKLAEVLDLPHAELTAGLGDHWFPYRGLGSAIPTDPVVYRLYEGIMVYGHPIKALINEKFGDGIMSMIDCYVKVDKKPDPKGDRVVLTFDGKFLPYAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBR3</accession>
    <name>A0AA38NBR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793517">
        <property type="protein sequence ID" value="KAJ3781876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBR3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="342" mass="38964" checksum="655EF76F95DCCD6B" modified="2024-01-24" version="1">MAHSADSEQLMNDRQLGAPPMLDSTNENLKLRRQRSSHSDEGHSNRPISIEITPGLNLIDLSRTPTDSFLQEEPQGLTIQDLDTEDNEEEVPAVHQANFDISSPNSSSFPVQISVPVEPPSPTAPMVIPTKRSIRFRSRVRITSGVHRKHHPQDRTVPLRPNGLLSPSEGDTAVSSCSSSPSSSISAPIRFREDEATVSPKWGPLGQRVRLFVSQQREKAKQAQANRETHERETRRRYLLVYGTDASTARDFVGLPEHEHEREPLLGSTRTRSRKTPASFGDDDDLDLYEVEAERDYQAKLNHEIDVIFGKWPGRMLNRHWWWWQIKPIVCCSYVEDWETEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBT4</accession>
    <name>A0AA38NBT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_91138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793508">
        <property type="protein sequence ID" value="KAJ3781996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="441"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3781996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="613" mass="68457" checksum="E75DEC78935F9F19" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCB1</accession>
    <name>A0AA38NCB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_396371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793422">
        <property type="protein sequence ID" value="KAJ3783391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCB1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="236" mass="26091" checksum="C08CC555ED9589B9" modified="2024-01-24" version="1">MFSIFFSLLCISLILTVYSSWFAFFLPCYATYKTLAQRPIIEADVQKWCMYWSVVGAFVGFEYAAGWLISWLPFYSEIKTVFLLFLSLPQIQGSTFVYNAYMQPFFTKNEKEIDAGIVSIQSNILSFVQSRLSALWELLWSVLSKTPVSQGNADSTQQSQSAAPSISFDAAMGLFKTYGPSLLNSLKPAAAPSGFAPTPASLTPTTSSSSVTTMSDLDRTPLNEVPPPFPEPVHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCB2</accession>
    <name>A0AA38NCB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 71-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_389122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041351371" evidence="2">
        <location>
            <begin position="25"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="469" mass="53203" checksum="C82BC1349E06B4E2" modified="2024-01-24" version="1">MKVPASSLFLYAALFIALPSFSIAHDLRHSYASSKREPRDKALASASNATDNTTHDDIADLQKRDGSKYVFVHHYIRSYDYDYNLWVNDFNQIRAKNIDAVALNVGRDPWERQRVQDAYNAAAAVGVGVFISFDYTSFDCSVDTTVEWANELSGLPAQFKVDGRPLVSSFSGDCLGPGGWQAVRDRTGGFLMPFIYNIDYQQLRRGGSWGFLDTWQCWGCSWPQGDYDKNTEDDHYYMDILGPDRYAATASPWFFTHYNYKNFLLRADSWLVIARWEELISMRDQLRFVEVLTWNDFGESHYLNSGPPTEGSQPYGTTWTNGYPHNAFFDLISYYIEAFKTGSYPAIATDTIYFWSRPHPAGINANNDGLSRPQGWDWTSDNLWAAVFCSSTCSVTLQVGTYSQDFNNLAYGVNKISLPLNAYGSITVKMRKNGQEVINYTPSDFQYRGWTDQYNFNAYVGSASASGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCJ7</accession>
    <name>A0AA38NCJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793384">
        <property type="protein sequence ID" value="KAJ3784261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCJ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="332" mass="34364" checksum="DC85EB00EDEE81C5" modified="2024-01-24" version="1">MSQTVTGGVASSRQLGLGLGQSNWILCTSGDLRLTIAGNQLISPLGVTGPAQFLTTLGSLTPWTVTQTNPGPGSLCPIGRQRSATVESSAPGITDVATPNPFISTAQALSPFNRACFARIQNNQTRDQCRTNTGFSTVCLSDANITAVRSTPIPEEPHVLPSMASLRRMYQPPDTAPCTRAPSVASESEGHSSIVDGEESVHEDFQDPDVPDLPPDRELHPMPPRAFAGDGGGNGGGDGGGGGGGGGSAPRLSAANSPADNTIPKGETLALSMLHSLITSLNGIQMSIAKPAVSKSGTSKAKLRDPDTFDGSNPRKLQSFLVDLTLIFANRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCN9</accession>
    <name>A0AA38NCN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_357467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="MU793371">
        <property type="protein sequence ID" value="KAJ3784591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="292" mass="32048" checksum="47BDC0F257D618E5" modified="2024-01-24" version="1">MTSPVLEKLSSNKSFEGELIKYKFKSAALGGLPANFNLFLPTNASDSDKVPVLIYLAGLTCTEDNGAQKGSFLGPASSQGIAILFPDTSPRGAGIDGEDDHWDFGTGAGFYLNATDPKFAAHYNMYTHITLELPAVIEAAGIPIDWKRQSIFGHSMGGHGALTMYLTSPQKQYRSASAFSPVSNPTKCPWGEKAFEGYLQGGIEEAKDKYDATELISKNKEPVHILIDFGTADNFYKQGQLLPENFLKAARDAGYDEFQVRVRSQEGYDHSYYFISTFASDHVHFHANFLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCZ3</accession>
    <name>A0AA38NCZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_195621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCZ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="4">
        <location>
            <begin position="818"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="885" mass="98764" checksum="4D2FB65D99BC109F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDB4</accession>
    <name>A0AA38NDB4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Etoposide-induced protein 2.4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_167092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDB4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="364" mass="41336" checksum="AE042CB6A9C0FA39" modified="2024-01-24" version="1">MSYSPSTQSRNNPSARSLYPSFLSVQESLLLQLNWARHGLVDAFRWDHVISTIAGDSQIRANVYKSLLLNSLSLTSIYTFDLLLLPLVQDQQKWLHRNVGWFYQVLWLLPVIGLSFYLNSSWCNIIAERTFVLKHGNRSAVQQQPVTYTGMLKSIATSAYRVVMVFTSLVVSFALGNIPYAGPILGFFFMCWLDSYYFFEFVWIARGMSLSRRVRHLEERWAYYFAFGLPSAALCTLGSGLANAAIFALVFPLYIVMAMHARPVPTDPYNPVSDADVVRHPSPFIPIRLPVFAMVMFLNDWIVRILSVGGGSRTRNTHRRGISDDTESVEEGERIKMQSKNATSSFQSNRSSSSRINIGRRKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDS6</accession>
    <name>A0AA38NDS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_235086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDS6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="158" mass="18403" checksum="53DFC3FF676B4B3E" modified="2024-01-24" version="1" fragment="single">RLLHVSFKTQRHLVGPPDPISHLRPIIYDDVPPPPVPAVVNHPYSLQEFDPDPAKNLNAYEMQWKLQRQQLDDLSQNFWLDSNARSESAKEAVLASLPAASTPMDRENALSEFYKQWLLQESERVDEYSKIWRSRNWANIILAARVTYSRFPSRITDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH45</accession>
    <name>A0AA38NH45_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794662">
        <property type="protein sequence ID" value="KAJ3779552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH45"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="244" mass="27069" checksum="3499E557D234FE8D" modified="2024-01-24" version="1">MAPTASAKAKISAFHNMALKIATGDEAGVQLTNSLSNPLLQEAFTKHLHAKLSNVGIDTKSPQIFSDFMAWANNPAIYLPDQVESAIKQRKLSVERGKAIKKELIRALGLTPAKGEGVAAALWASATVVELPRLETPYPPRDKWIIENSEIWGMWEAHITKHKQPDPRVRRRGLHALDETQLQCNVAPDESVIVFDKDSGELIFAQLRNFCQVPAIVEWVDSVVKKNLSVQRNVRVRGLILGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHJ6</accession>
    <name>A0AA38NHJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_413679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793630">
        <property type="protein sequence ID" value="KAJ3780917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHJ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="514" mass="56271" checksum="853B1EEAB8016031" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHW6</accession>
    <name>A0AA38NHW6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_429629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793497">
        <property type="protein sequence ID" value="KAJ3782132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHW6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="313" mass="34716" checksum="28C6F74525C363F1" modified="2024-01-24" version="1">MDNKKVAIFPASGKLGGSLTRHTLKLLPAHDVVLISRYPSKIPDDYRNSGATIRAADYDSPKTLEDVFSQVNVLFLISYPTFQHEHRTKAHKYAIDSAHKNGVKHIFYSSLAFAGLGDQSVAHVMQAHLDTERYLAQLASKDPSFSYTSVREGLYSESFPMYTAFFNLKNPTNEILLPHNGHAPGLAWVKIDELGEASALLLAKFYAAPDRFADKNRVLLLSGPREWSLNETVQALSRVVGREVLIRQVSVDEYAAQKHVGSGLTINGNNLAKEWATVYDAIRSGETSIVTPLLKDLLGREPEDFEATIRGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI84</accession>
    <name>A0AA38NI84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_361466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793429">
        <property type="protein sequence ID" value="KAJ3783242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="241" mass="27050" checksum="C5A0094B0AA05124" modified="2024-01-24" version="1">MNVGLLSSLIAAAFSSQAASRLGMKNLIRLTHCLFPSPLNQSIFQILSILFPLRLLHTMTTYGLPYFLEDKTGRLSGSEFVDIHDRLRLTYRLSTDRSSSHTAFMIYNTSSHISHPSFLQALVALDFGPGHALGTVSFSSKICLPMKKYLVKVSSKGRTYRFIASDSQEYFWSWRSQANQEWTCTNTSGYLTAYYSLKTPGEPQYEGSSGCSLTIEESFGHLAPEILASLMILRHMSEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIC7</accession>
    <name>A0AA38NIC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_435833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793411">
        <property type="protein sequence ID" value="KAJ3783617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="385" mass="42538" checksum="7F8C3E0BB366A1BB" modified="2024-01-24" version="1">MVLYNGVLLPFDRLNNPFSLTLAIPFLSLFFSPMRTLISLLPALVAPIFAANIQRHPPSLIAGHVLRQENNPDPTVGGSPDGGWQSMPQVTDATAYPNWMLDNSGAMLPVYQTTGLISTKVTRAVIILPGKPRDCWYYWNAMNNALYLANYQNSSISRSQISIMAPCFWTEADVEAGAAQNDVLVWGMTTWISGHENVGPNGISGYSSFEALDALIEYYMNKTLYPNLNTVVLAGHSAGGQMVQRYVGLRQTMKDDDRLHFWVANPGSLMWLSADRPYPNASCAGVDDYKYGLGGDFPAYGIDLDRDSILALYNSRIVNYAWGTADNGNGDTRCEAETQGSTHYIRGKNFVSMTNETFGWPVNATVDWVDGMMESVEGINKLFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIU5</accession>
    <name>A0AA38NIU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_401357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793373">
        <property type="protein sequence ID" value="KAJ3784532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIU5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="37678" checksum="A0510AA0E0A20AE3" modified="2024-01-24" version="1">MSPEGDTSMKFEPSPAPLIVDDVGSNAVFHFQSNLCNGINTLTIYVTSSSGLVDARPTSTPASGSVSQAPDRSDVTVASSPGGGCLDTLDSSFGWVKETASLDPLFSQFQTSTFSQNTPDVSLAPTIDLIPHSESNQGYSEVIQEYEENVNTLTSGFPSWADPSIFAMPFPDYPSNSIPSSSSSLPTTPSASITTSPASDFSEISMDDLASASSPEASCQCPRNLSIAPKRVTSSSSLVHRHRDTSTSHSRLQSQPNSYHNHFRSHGNPVKTSFPCTFAPCPEVFSRKHDRMRHEVAQHGLQCQWVCDRCRKFFSSDKTLAKHRCNVNIDVRWTAPTRTNTGQDGAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJI6</accession>
    <name>A0AA38NJI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_434323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJI6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041315052" evidence="1">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="237" mass="26751" checksum="5829DE1A426CBA5A" modified="2024-01-24" version="1">MLFKGLCRFILTMNVLSLVTASPIRQSLDLSNASAFRRTADTAVQNTTANWSNSHSTPSTKFRKRAPTTLYLSGCTSVLNWSLRDPSVVRKPGPFHLSPEGGLYLTHRLENAEAMARLEFKNCVPVHVNGFLSKFMVVSYDFDDTGLNIMDLDNWHWYQHDSVIANLPNWCTGSYTQSFRLTEKSLLNHSTLTPAAHYGAGLTDLWSLWVLKMGRDDPNRINPISRLSLVKVNHYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJQ7</accession>
    <name>A0AA38NJQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_267997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF199">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="5">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="129" mass="14820" checksum="246A3381437D1ED9" modified="2024-01-24" version="1" fragment="single">WHAISRHIPNRNNKDCRKRWFAKLAKADVAKGNWSPEEDERLLKAIEKYGSRWTAIATVVETRNSDQCAKRWKDTLNPSIDRTGWTATEDAKLVEAVNTHGKVWSKIVKTHFPGRTGLAAKNRFEAHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKI4</accession>
    <name>A0AA38NKI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_288475</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKI4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="48"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="13">
        <location>
            <begin position="181"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3787322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="373" mass="42799" checksum="53FE389864204448" modified="2024-01-24" version="1">MEITLHSSTSMLDNDPLYEEKDPIDIKAEVTKSTTEFSQVTQSHERWVTLQFTWAGKSFSLDIADSDRVFDLKTTLHELTKVPPERQKILGLVKGKLPPDQGRISDLKLTTGKKFTLLGTPEGDEIKDPSQLENLPDVVNDLDIDFSKDPNAVKRYKNDQRNIRKVKEMTDKLNVNIIHPLREGKKLLVLDIDYTILDTKPLTSGSLPPAECARPKLHEFLEAVYPYYDICIWSQTSWIWLETKLVELGMIGANRNYQISFVLDKTSMFTVFTERDGKPWQHSVKALQIIWNHFPQFNATNTIHVDDLGRNFALNPQCGLKIHPFKNAHTEEAQADRELDKLARYMVYIAPLSDLRTLSHANWKTVLKSLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKJ6</accession>
    <name>A0AA38NKJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase C13 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_147860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKJ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000016">
        <property type="entry name" value="GPI-anchor transamidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041310914" evidence="8">
        <location>
            <begin position="22"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="413" mass="46062" checksum="100A413C4DA2C2B8" modified="2024-01-24" version="1">MRLPSLSLLLLFYFLIFSCDASSQHTNNWAVLVCSSRYWFNYRHMANALGMYRTVKRLGIPDSNIILMLADDAACNSRNKFAGSVYANPGRHLDLYGENIEVDYRGYEVTVENFLRLLTGRLSSSVPRSKRLLTDSSSNIFIYLTGHGGNEFLKFQDNEEVSAHDIADAFHQMYEGGRYNEIFFMVDTCQANSMYSKFYSPGILATGSSVVGENSYSHENDYDIGVAVIDSYTHYVLEYMEKVNKTSRLTMADLFTSYDVPKIGSHPGVRSDLFERPLGPGNPNHPMSEYGRGRGWTVEGGGEWMGREIEAGKNGRVLREALITDFFGGVVDVDVNNEDDAELRLFEDPECISTPKAPLSPSTNTYSSPPSSRSSSSLLDTLDTYPLLRPSLAFILLGALFVLVFSGMTSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKX7</accession>
    <name>A0AA38NKX7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-Aspartase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_272965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793407">
        <property type="protein sequence ID" value="KAJ3783723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="701" mass="75653" checksum="5F0EDD1A0311A9E4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLQ1</accession>
    <name>A0AA38NLQ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uracil-DNA glycosylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_356125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3784998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLQ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="240" mass="26739" checksum="7C609E4219BC9F6D" modified="2024-01-24" version="1">MHSLNHPQPPISKPAKKKKPARGYSSPEVYAHLNHLNDCISESLDIIFCGINPGQRSAEIGHHFGHPSNHFWKCLHLSGLTPERVPPTEDFTLPERYQLGLTNIVERPTAEASELKNSEYKDGIAPFFSKMARYSPRIACFIGLQTGRIVLDYVMRSRPKSERPTFSPGLQPYKLVHSKPRNGSAEAGSETVFYSIPSTSGKTQGYQIPDKVKLFTQLGVDLKMLKDGNLVTANLVEITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM54</accession>
    <name>A0AA38NM54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_353145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3786003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11271" checksum="59AB3B1D4700E25B" modified="2024-01-24" version="1">MSANDSQKNPERVAAGLRGTLNNDSVSDEAKDRAADRLRELGGDFENKTSRASAGTGDQHKNQVLGGYKATLHNDKVGEEAKAHAREVLEENNVSEEPLPQSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMD8</accession>
    <name>A0AA38NMD8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_351246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMD8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008265">
        <property type="entry name" value="Lipase_GDSL_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01098">
        <property type="entry name" value="LIPASE_GDSL_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="260" mass="29630" checksum="93E5E0BFC2C6985E" modified="2024-01-24" version="1">MSANVQNSIMLFGDSLTQGGWEPGMNGFGANLAHRYARKLDVINRGFSGYNTEWGIPVFEQFFATREQQKDLQIVRLLIIWFGANDSCLVQSPQHVPLAKFATNLKYLVNLVQSPESQYYSPNTRIILATPPPVNTYQRKANLDARDPPLLLDRDFENTRDYAQTVKDVAQEEEVGIIDIWTKMWDAAGHDEQSLSDYLYDGLHLNGAGYQLMYDAVLETIEKTYPELHPDRLEMVFPGWGMIDPNNVVASVQKREQRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMM9</accession>
    <name>A0AA38NMM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_386309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMM9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13682" checksum="7693878A995D92F8" modified="2024-01-24" version="1">MQGLVIKNTGSTARDFCFLERNILSHLKLALLFSILSSSLILHARLVPDSNENTTGSKLTTPLSGLELSASLLVIVGGLWEYFNGYRDLLDMRAFLAGTKPHLAVMVVVVAIILVTCVILLADQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMZ5</accession>
    <name>A0AA38NMZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_288199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMZ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="171"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="341" mass="37259" checksum="B964436726CDAF88" modified="2024-01-24" version="1">MAYEGITFRGSRNGQIHKERFLRQNLKSDEVVIQITHSGICGTDLHFMHADIVLGHEGVGVVREVGESCKTLRVGDRVGWGYTYWSCGRCSACLTGHESYCPIAGKYGAHHLDQGSFGSLAIKPEQWVFRIPDGIESKYAAPLLCGGATVFSPMVEFLKPTDRVGIIGVGGLGHLAIQFAAKMGCDVVAFSSTEVKREDAISLGAREFYATNDVADYTTLNVAKPLDSLIIATGAEHLDFSNYYKLLKPVATVIPLTISFEPMVVPTIPTIANGIKIAGTTPSGILIMSQTLEFAERNNIRPIIQEFPMTEDGIMDAMARLKNGDIRYRAVLSWQLLEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNG2</accession>
    <name>A0AA38NNG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_414893</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793668">
        <property type="protein sequence ID" value="KAJ3780710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="53"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="295"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3780710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="379" mass="43219" checksum="81E6256C8C374B30" modified="2024-01-24" version="1">MAYDSANGCMSTSSLKSEAHNFRKGRSTLATECTGRERVLLRKSCTKLRIDQFHIIAQVGQGGYGEVFLARKQETGEVCALKKMKKRTLHKMDEIRHVFIERDILTATKTPWLVRLLYAFQDPQHVYLAMEYVPGGDFRTLLNNSGVLKEEHARFYISEMFAAVNELHKLGYIHRDLKPENFLVDGTGHVKLTDLGLATGALNPKRIESLKVKLDKVKGNQVVHRSTLERRSIYRSIRNEDPRYADSIVGSPDYMLNEIYPTLMMLCFSFIAHASTRYSTMSQVTAHPFFTKCIPPVHWDDLRFTRAPFVPALDSELDTGYYDDFTSLEDMAKYAEVREKQKNVDKVREKEEPFGRGVWVGFTFGKNGPEANVGKLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP08</accession>
    <name>A0AA38NP08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_275586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793477">
        <property type="protein sequence ID" value="KAJ3782420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP08"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="467" mass="50718" checksum="A9B066F82420F65C" modified="2024-01-24" version="1">MSSPNVDTTVSPLGPIDPASVTEAGSSGENEKAAPWIVRKLVGSMTGRIVMSSYESLRAAGTTVICLSPWGDQSPLTLPCIRFRDLAVHTVIAATGGFAAIASPVMGPVSDLVVSSFGDTILVELGLHAGFDLTTKAANDLIIEHGIKHAIPIHSSRLETTHVKVLLITLKFKHTMEDAALGFFRSSIHKDTDLFAAVKDYLAVEKGWLSPYLFASSRRPIIPRSMKPDVIFCHGPFLQGDYRVGEALLNESASIISFCQAPPPAEALLETPKQQYSLSDLKDLKLPSLSNVFSRSRTPSPEPQLTPLPAPPVPRRMVILVVGIKPHRKLWSTSARPEESVIRYILLNGCPAIVVPVKLGAPLIAWDALTLEQLWDVDLPSADGTPSTSGKFEGIVNVLYEFLDLCVDWVRVEENKDGDAMIEQGKKEKVKDALQLLVAAAIRSKASKEVRKEVDADRAGIAMWRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQU2</accession>
    <name>A0AA38NQU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_343327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQU2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="596" mass="67475" checksum="310D78FE60B95045" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQV0</accession>
    <name>A0AA38NQV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box/LRR-repeat protein 15-like leucin rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_343275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="216"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="452" mass="50348" checksum="4CAAD383927FF579" modified="2024-01-24" version="1">MSNRLQGVESFYEDMISVTNRLPLEDEFRRVRHLTLHMPFASTVSDDDLARIFSSAPHLETVILSGIPDITDRTVVLLAENAINLQSVDLTGCQQISDVAVLELTAKSLPLQCIKLNAVVGLTDPSVSAIAKSSPRLVELELSGLPLLSPLSVRDVWSFSRKLRTLRLAHCPLLTDKAFPSSIDPPAESEGEKEKPLPPRPITWVEQLPPLILRHTADNLRVLDLSSCRITDEGIEGIVAHATKIQKLNITGCSDLTDRSLEAISTLGDNLDVLILALVTNITDRGVVYFARACRNLRVVDVAFCRNLTDMSVFELSGLVSLRRLSLIRVHKLTDIAIFSLAEHSWALERLYISYCDHVSLDAIHLLVKNLGRLQHLSATGVPSLKRKGIHRFSDPPPSDHDPDQQAAFRVFSGMNVEGLRKFLDKEDQRRRDAEARNIPFVARSDDKLDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQX8</accession>
    <name>A0AA38NQX8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_343428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQX8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="540" mass="58860" checksum="5DDD25D280BF73D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRG6</accession>
    <name>A0AA38NRG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_342302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRG6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117485" checksum="6A990E7C35ED83C8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRJ8</accession>
    <name>A0AA38NRJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_342495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRJ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="250" mass="29114" checksum="3367762A483B3DBF" modified="2024-01-24" version="1">MLFASSLNGKLPRFISPVQIQRYSTALISKSQRLGHKRFKNWFEIVNVKTAKVGPRLAWLLRHGARFHDLYVRPDGFVLVDEVLRINPFRRLNLADLKEIAKIDPLKRLQVKELRPRQWWIRAVAKHSIKFVYPTWKEIMNVSQVKGAIYFTDADGWQRIRLEGIRKGPDEDMIHLFQTVTEHFGYSRAESSTIIVIHIDVSQALRYGLTFFAKHDKNIATEGDADGCILPHLFQKVERLQWSKAVILDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRP1</accession>
    <name>A0AA38NRP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_259675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRP1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="102" mass="11221" checksum="A4A92263119620C9" modified="2024-01-24" version="1">MQIFVKTLVGKTIILNVESVDTVDSVNQKIQDKEGVPSSQLRLIYNNKQLENGHILSDYGIEKESTLHLVLRRVPSGLDFLCNLPLARLPCCTPVGNSGSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRV7</accession>
    <name>A0AA38NRV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_259491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRV7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="420" mass="46079" checksum="E2B7BF7677CF6CB9" modified="2024-01-24" version="1">MLYSKDFTVAICGGGLCGLTCAVAFARAGISVTVFEASIFSQEAGAGVGLGPNAIRALKGLGIFDAVLAHSDQRKPAPRLFNFVSGKNPHDCIFDYETNCEDPVALAIYRPAFLEAVLALLDPSIIMFRKRCTSLDVSETGKHMLHFADGTTHEADLVIGADGVRSVARRYVIGDVPRNPLVYTNTVAYRGLIPTEDLQKAGIQTDLTRRPICFLGLGKHIICFPIKGATVINIVVFLAEHDEPLQSELPYPWVESVSQDELKDSCKDWGHDPMIILDHLTNPSKWSIHALDPPLQSYVRDKVVLVGDAAHAMLPHLGAGVGQGFEDVSVLVQLLTHPQTQKSNLYDVLARYNDVRPPRANDVLQASARMGKLYDSFRSSAQDKATLQKELSGIWEAVWNYDLDADVVDALEMFRRSSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRW0</accession>
    <name>A0AA38NRW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sly1 vesicle trafficking sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_259526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="686" mass="73584" checksum="6AC7615C9E820856" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRY0</accession>
    <name>A0AA38NRY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_392334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRY0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="359" mass="39516" checksum="B526F203274F8AF4" modified="2024-01-24" version="1">MPEVYVQSFTHLKDRKSADKALEMLQRVASLVKPIMRKHSWVLPVLSEFFPDNPNLLDVNMGQKILVRLRPPHSPDSFLSEEDVVQTMLHELTHNVHGPHDEKFYKFLSELQEEYDALQRSGYAGEGFFSKGNRLGTNVSHNIPLHLARAQAISAAEKRRKMSQTLGGGGRRLGGGDTGQRGLSLRERAKRAAERRLLDEKSCGQGEMAQLEAAKAAKESVENNIIDLTMDNDDIEVIVVDNNVVVPGPSKIAVQLPQSTVTSSLPPRPPSKPSSSATGKSVQINQPPLPNLTTKPPRDNWECPICTLINPAMLLQCEACLANKPIHAQAGWSCLTCGETGMPHEFWSCSFCGAIKAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS60</accession>
    <name>A0AA38NS60_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_329389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041465743" evidence="1">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="277" mass="27277" checksum="10AB20241EC73641" modified="2024-01-24" version="1">MKFMTALFAAGAAVISVSSVPIRRDVDPNLVPQFGLAADINPDGTGNCDGIDGPNGQPILIPCTCPPDRDTFIADLNANVAAGHAVNNPSIAVSFPSDNSQASQLARIDAALVTLQNLNGAGVGCPASSTTFVAQQAAIQAGSSVAAAPASTSVAAAPAASAPATGGVDVSLVPEFGVTAGQSPDGTGNCIGINNIKIPCSCPPDRDTFIADLNANVAAGHATNNPSVSVSFPTSQSNADAATRIEAAIVTLQNLNGAGVGCPAASTTFSAQLAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS91</accession>
    <name>A0AA38NS91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_341370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS91"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="120"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="376" mass="41231" checksum="73F05E18E6E5C620" modified="2024-01-24" version="1">MAGSHSTTKHVVVEIALLVASQAALYYTLRWAIGSFTGTGDKKNVNAKQMEALKRLGHTELKLNEYESVVANEVIHPDDIPVKFSDIGGLDPIIASLRESVIYPLLYPTLFTSNSSLLGAPKGVLLYGPPGCGKTMLAKALAKESGATFINIAASVLTNKWFGESNKLVAGLFSLARKVQPSIIFIDEIDSFLRERSSGDHEVTAMMKAEFMTLWDGLLSSTDRILVLGATNRPNDIDSAIFRRLPKRFAVTLPDSHQRMKILKLMLQDVSLSPELSIEILARASEGLSGSDLKELCRAAAMVPVREYMRENLSNGEVLTEDQLKNFKPRPVTLQDFLSFENSGLLSKPVSPLPEDRSRIDSEDGVDAREASIPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS99</accession>
    <name>A0AA38NS99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_282853</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS99"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="14">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="360"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="508"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3790216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="585" mass="65804" checksum="47DDBE3663F23372" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSI1</accession>
    <name>A0AA38NSI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_383388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041245764" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30022" checksum="285CB927F61808C6" modified="2024-01-24" version="1">MASWHLILSLLSILDLVSYDLAFSLAIPPDPITNIYFPVVWQRDAGDSTTSLLDRKYHYPPPIHTFGGGSYFAYVNSTLGDSVDPQATSLEVTTHGFLGPSFPATPASLSSSTSASTTDVGSPTTTAKRPSFGWDYQLKSALHAIAGAVVGGILSLVLIAISGFFFFSRTRRSRKARDSSVFLAQQFETVSTRHSPSTTEPFDWDGLTVLHHASGVLDSGVGPSTSNCGTEPGIASGTKADTERPPPSYDDARSAAGVSTVSMTPGERESRMKVYGKSAMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT59</accession>
    <name>A0AA38NT59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_391887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT59"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="18596" checksum="03929BF563157DC3" modified="2024-01-24" version="1">MEQIINFDAILFPADGRSPSLVSLMTSPMTTNHHSSYTQNPTRMPHPEVHMDYIDENLGSRAWKYQLVEALDGMNRKFACPYIIFYPVISRDGMPFPINKAIKDMQGQAYNEEHAWRGHIVVGKYRDNPFTSMMDISMADFPILKNYLEMHGSPGQVWLIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTE6</accession>
    <name>A0AA38NTE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_414032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="728" mass="79509" checksum="6E092535443D112B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU26</accession>
    <name>A0AA38NU26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_301940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3791120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="396" mass="43360" checksum="03777D4349C7FC41" modified="2024-01-24" version="1">MSNSREDHYYPSLGKTGKNSSLSGDQGFFQTGQGGRTVLPPISSTFPSSHLPASSYTHQYTQPRSMPTRYDYNHALYNQWPGNNQSSAPMNYTYYDNNTSQNYYSTYPPSRTSPAVPEHGAESRKLPPLTTSSGLGRDDRWTSNTASYSVGPAENPSYSGIRSPTASYPLSFNAYPSTSATNHYGSVPLTDAPNQSHLQTANHASMILPETHRPISPSYAPAGLQIPPSYTPPPVSPTTGTVNEPTIKKKRKRADAAQLKVLNETYARTAFPSTEERQALAKLLDMSARSVQIWFQNKRQSMRQTQTRQSSSSGASLHQSFGVSGSGEYEGHSTSGYETSASLHMPSSAYSVPRSSQESHSSSVLSPTVPHRRPRSQDPALTDTIGTKSQQWSPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU78</accession>
    <name>A0AA38NU78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_338282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="121"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3791244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="599" mass="66072" checksum="18B7B8867B0D5011" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU96</accession>
    <name>A0AA38NU96_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_301661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU96"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="361" mass="40788" checksum="A9C0EE989845B033" modified="2024-01-24" version="1">MTSNTQKTELNVVMGSATFGEEGQPGARIHDLDKIEALLDIFRAHGHTDIDSAYFYAGGTSEVVLGKIDWKSKGLKLETKLPAIFNEQQKTVHGTEETVSHTYKVQRSLLGWPLGADYLWNEQDIKIHILKSLKALDTEQLDIFYLHTPDRLTPYEVTMKAVNDLYREGYFKRFGISNYTSWEVAELVGICKANGYVLPSVYQGLYNAVHRAVEPELIPCLRKFGISFYGFNPLGGGLFTGRYTSPEDDVGEGTRFDPNGVQGKLYRKRYWNDHYFEAMSSIRTAADAHELTMAEVALRWLCHHSVLKRDFGDSIIIGASSLDHVKQNLVDLEKGPLPAEVIDALDKGWEIVRPYASPYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUD7</accession>
    <name>A0AA38NUD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_2227</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000115">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="14">
        <location>
            <begin position="241"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="13">
        <location>
            <begin position="315"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="409"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3791285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="476" mass="53403" checksum="CC76F96D8697EA3C" modified="2024-01-24" version="1">MSGARRCYQVAFKRYLSRSLYTHAYRDPKPGDKVVVGMSGGVDSSVAARLLANQDYDLSAIFMRNWDTRDESGTDKGCEWEKDWEDVQRVCNSLGIPCTMIDLSREYWNRIFQPALDVWESGSTPNPDVWCNREIKFGALLEHLPVNPTTGVSWFATGHYARKGWSSHGRPQLLSAKDQTKDQSYYLSSISEQGLSRALFPIGEFTKVQVRELARKYQLETAERPESMGLCFVGERGKFSRFLNSYLQPKPGPIIDFTTQNVIGNHAGLWTYTIGENAKVAGQPFKTFVSHKDPIKNAIYVVPGSSHQALLEHRVICKDWKWIWNDSPPPGISEPAGFRAAVKVRHRQDNQTCIAKIAQDKSLEIITDEPMRGVSPGQVAALWDGDWCLGCGVIASTGNSLLQSRQIIHDDPMNPPRTATQCNQVQKQKKLTSTSRGKRSPDHSGFHKRSLKLQSLQQISRDQSSKAPVGEIMLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TY17</accession>
    <name>A0AA38TY17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_343880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TY17"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="237" mass="25549" checksum="2B9AC684072CB0EA" modified="2024-01-24" version="1">MSYGGYGSGGYAPPPGGPPGGYGNPPPASYGSPPGGYGSYPPPGGPPGGGFAARGSMGPPPGADPQLWSWFAAVDTDNSGSINAHELERALINGDWTPFDLDTVKMLMSIFDADRSGTIGFNEFAGLWKYIKDWQNVFRHFDRDRSGSIDGLELRDALSQFGYQLSPQLLDLVQRKYASSVTGARGMPPPGISFDRFVRACVAIKQLSEAFGRLDNDRDGWIQINYDQFMQTVLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U000</accession>
    <name>A0AA38U000_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_340722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U000"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="736"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="602"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3790407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="856" mass="92760" checksum="3B9FAC13A1AE2F21" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U096</accession>
    <name>A0AA38U096_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Topoisomerase I damage affected protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_340353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U096"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21459">
        <property type="entry name" value="DLC-like_TCTEX1D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14679" checksum="130986B7EB39BE1E" modified="2024-01-24" version="1">MANASGLRSPTTPRSEVSSPRPKFDSELLKAYMKKLLSTTLGSSVWPEPKDRDRVKSWMKEIGDRVKDRMLEIQPKGFKYIVLTQVNENLGQGGRADMVCHWEDTDTVAQEVYANDSLICICIALAIRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7B4</accession>
    <name>A0AA38U7B4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_329111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7B4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041291143" evidence="1">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="196" mass="21202" checksum="D0ACE2896341B0FD" modified="2024-01-24" version="1">MSRFMILVILGLVSFACAAPLQPKPTPTTTPGLATFTLKPSSSSSSSSSLLLSSSSSPSTAIALTPSFVPRTNTNSKSKTFDVSFLDTRSNDNKFIQEPIRQFLELVDIEVSNFIGTPNFLGPEHDRIFHFELIRDGKQEYYGAIGDRNLAIDKVAATKPGYSYDGSGLYGSLTVVGSHGPLAPHTVVFKVEDRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8P9</accession>
    <name>A0AA38K8P9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASST-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_80166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793474">
        <property type="protein sequence ID" value="KAJ3782469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8P9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041380083" evidence="1">
        <location>
            <begin position="22"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="526" mass="56888" checksum="4013B42D7590CF77" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8W9</accession>
    <name>A0AA38K8W9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_362054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793440">
        <property type="protein sequence ID" value="KAJ3783024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8W9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040221">
        <property type="entry name" value="CDCA7/CDA7L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169">
        <property type="entry name" value="OS05G0300700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169:SF8">
        <property type="entry name" value="ZINC-FINGER DOMAIN OF MONOAMINE-OXIDASE A REPRESSOR R1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Zinc-finger" evidence="11">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc-finger" evidence="11">
        <location>
            <begin position="263"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="738" mass="82483" checksum="887A0C8312DDFE5E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB63</accession>
    <name>A0AA38KB63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XAP5, circadian clock regulator-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_426817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB63"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="194"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="332" mass="38945" checksum="E6710B0776517103" modified="2024-01-24" version="1">MSTSKAEGRREDALAKQREQMREEFERQKKNLIDETEKSRPSSHRFVGQNDSMEDSLKNSTVGLVHLEEFQQKRRELEEAKAREAARTNELKDDMKKVKKRKKAAKATLSFAMDDEGEGDESTSKDSSEQRRSASKDEEDVDGGERAKKRGKFRKNPNVDTSFLPDREREEAERKERERLRQEFLRRQEELKKEDIEITYSFWDGSGHRKSVVCKKGDSISTFLDKCRQQFPELRGVNVDNLMYVKEDLIIPHHYTFYDFIVNKARGKSGPLFNFDVHDDVRLLADATREKDESHAGKVVERSYYQRNKHIFPASRWEVFDPEKSYGKYTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB71</accession>
    <name>A0AA38KB71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_348802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="9">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="8">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="292" mass="31794" checksum="5AF56271024C14C1" modified="2024-01-24" version="1">MQTVSEIDDLSPGGGSLMIAWQLKGKRVLLVGGGEVGASRIGHLLRADAHITLLSPEKGLVPTTKDYIAKYPQRITYYGRSFTGPAELHKMDLVLTAIDSPAASREIAGLCRQAKIPVNAADIPELCDFYFGAQIRDGPLQIMISSNGNGPRISALIKERVQASLGGYEGLALSKIGMLRAELKKRVPDIGGAVGRKRMKWMSKICNDWPLIDFTLLDDAMIHKLLDEGWEKNRVPTFEEVCEKPKPSVVQATSSSTSGEVSKTSRSNFLIPIANFLAGAVFMAAVMLARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBL2</accession>
    <name>A0AA38KBL2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_417052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793788">
        <property type="protein sequence ID" value="KAJ3780328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBL2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="348" mass="38834" checksum="D3B8CDFE2317A001" modified="2024-01-24" version="1">MARVFLNVRANVSSLRRVDSFETRRLVLANTPSIKFFIYDGEPSGTLVSGIDAVRESIKVVSLDELRALPKSQPTEPLKARLPKPETMACIMYTSGSTGPPKVVCIPHANPVAFVGAVYMLLGHHLTYDGIYLAYLPLYIVELIMLFVSMTPGYGRVQHCAQKCSGSDRREATGYIVWWCCPQSRNTKILGHRIGDGFAGVRNDRILWNVAILPPELMRYGSVSLPVPSIETKLLDLKDAGYLSTNKQPQGEVCIRGPSVTKGYYKRPDLNDDETIFTKDGWFRTGDVGQWNEDGTLSLIDRVKNLVKLQGGEYLALERPESTYKACNYVGNICIYLNRLINASNVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBU5</accession>
    <name>A0AA38KBU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome C oxidase copper chaperone-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_117444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBU5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000005">
        <property type="entry name" value="Cytochrome c oxidase assembly protein subunit 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="81" mass="9072" checksum="E0577A7D311C9990" modified="2024-01-24" version="1">MYQKIFSLWSSAPETSECQYDPTNPKVNPLNPEGLKPCCACPQTKSARDGCFLKYGPEADENCKELVQNHLACMRSLGFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCV2</accession>
    <name>A0AA38KCV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794202">
        <property type="protein sequence ID" value="KAJ3779801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCV2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="247" mass="27534" checksum="4CFFD0CDAB685375" modified="2024-01-24" version="1" fragment="single">MQFSNIPVRAKEQVIVGSGTTRWVAVEVLFPRNCKTLFIEKLFTTNRNEEDIYGAPDTIIEEAENPRIPVANFSEEAITISKGQLLGNGHDANRWLDQTGKIPKEDQMKFESQARVLKAIAEINENEEKHSTLIRSQTNLDKKSKSDQEIPGEEYGEPPVEGGPKTAEVVEDFTPSNKLLEEIDICKELSADQAKTLQQILVRNKEAFGLDGRLGNYSEEVEIPMLPNAKPIALPPIPLSPANREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDQ5</accession>
    <name>A0AA38KDQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_403286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDQ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="220" mass="23386" checksum="7A19F52A430A0706" modified="2024-01-24" version="1">MSHHTALAQLLSANAQWAKDVERLEPGFFKESAKGQTPQTLWIGCADSRVPESVITGAKPGDIFVNRNVGNQVNLDDDNMLAVLTYAVEHLGVEHVVVCGHTECGAAAACFGACSSFVPGQAPVTIPVDPADAPLNRWLAPLTTLAASLEISSAPANEALPLLIQENVKAQVNNLCRTEVIAKAWANGKSPKGKEVWVHGWVYDVSTGTIRDLGISRGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDR1</accession>
    <name>A0AA38KDR1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_40109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793396">
        <property type="protein sequence ID" value="KAJ3783958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDR1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="439"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="528" mass="60336" checksum="F49D7B83FB557107" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEL8</accession>
    <name>A0AA38KEL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NRDE protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_268993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793338">
        <property type="protein sequence ID" value="KAJ3785548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEL8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="294" mass="32516" checksum="4A9AB31AF078FB49" modified="2024-01-24" version="1">MCIVFWTLDHPDYSLIICSNRDEYLERRTRNAHLHSFKHEAHRDNILSGIDEVGGGTWFGMTRTGKVALLTNITEPPATFKSSRGSLVSSFLLSDSPGSSLQEEIEELYPRDARYAGFNMLLLAPASTATTELQYDASFVTNAGAGGAISSRPLSTIEKAGGGFSNGIDGQGGSEWPKVQHGMRDFQAALQSHSLDALTESEFIDRLFGLLTWKCPAPVTTRSGLRNTVEVAPIPITFESTKFYGTRLSTVVLIRRDGHVTFIERDIWKEVNGKVERMPASSERKFCFQLDTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH81</accession>
    <name>A0AA38KH81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH81"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="257" mass="28767" checksum="3751C4AF61BC612E" modified="2024-01-24" version="1" fragment="single">MNTSQLSSQFHRTGRRSLKGWTILFIAALSSTLLVITGYASPIPYSEHEHGSDITASGTSHRPPAHDLGIASRYLQLDSRGAVGLKKVLSRIALAINPDWVLLGFAYVEPEQGQRIGDGNSVSLATLELPGMTLKSTLSAIYLLPQLGLPAQNPDNRYWSCLVYASKKKMKNFRYPMSYEERTQESPPSSPKIVFFEDKNHKGITVMQVPNYPLVAEWGWGLLAECYQSPSNLPVKVRPSWNQWRERIVGLPKDRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI87</accession>
    <name>A0AA38KI87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="5" type="ORF">GGU10DRAFT_344495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="300" mass="32926" checksum="78AE0C613A85C65E" modified="2024-01-24" version="1">MGLTGLARWINAPSDGLLAIRKNILENHNGVVKGPWNLAVKSYRSTLTQTPGIHLPSERTMFTLQMYDNVFVLLEDPLAPTRADVVQAIADKAAPPNFHPTHYRSTFLTLNPPGALEQLLAQIKARWVPVRQTTTNATQRGQTSGHQLLIEGSVFGIGTDWLVRAGIVTMTGGDMKGMLLEAEYLPLPGLNIGPAADGTSELLSNLLTSVLPNVPDAKTVAVTISEAQWEDVLWDREEEEKAQKEVAQAKEREINGEDDDVFVYGVEDIPVKRRGDWTGVDRDRRSAFLIIGALKSEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKW0</accession>
    <name>A0AA38KKW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_231022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793641">
        <property type="protein sequence ID" value="KAJ3780854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="145" mass="16563" checksum="8438121D8E411F60" modified="2024-01-24" version="1" fragment="single">SLLCLFPEVEAATITSIINHEFRASDLYKLDSRYRDKTERQVLSLKGETLELTTNDSAYREYKSLNAIAVPLSTYFSILMTHAEAAGRVSAIGTDFFKYNAHLIKVTSEYDWSAVVGYHMAFFNKRHREMQSGDYSGWGKVDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLF5</accession>
    <name>A0AA38KLF5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Thiamine biosynthetic bifunctional enzyme Thi4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_278849</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793664">
        <property type="protein sequence ID" value="KAJ3780735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3780735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="523" mass="55179" checksum="4BFF1853076A0BB2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMS7</accession>
    <name>A0AA38KMS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_436516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793463">
        <property type="protein sequence ID" value="KAJ3782640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMS7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="37846" checksum="E56B32175B8F53DD" modified="2024-01-24" version="1">MYSSYIFRSDEYLSTSTPDTASNWTELIGSDVGDEGQTSSSSKHAFFLVFVVFQLIGLAGSILMLLTVCISKTVKRRWSWINFVFTWIVSCTSYSLLVGGPMNWQPDYPLCLTQAALVYTVPTLTATASLALVIQVLISVRAFAAPNPTGEAATNDRRNALLHRLYTLLMVSLPYVAGAGMFAVSLVIGLKDRETVTREPGGFYCNMLNPIPGKLSAVIVAVIMLICLCLSITISIILGRNWRAFSSDAHAPLATVLRVLCFSAFSVVAVVLGLLFFFTPRGKHGPGLQITLAIIPVAAVLVFGSQTDLVRSWKAGVQSCFHFHYRTESRVELKLNTESHDWEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMX0</accession>
    <name>A0AA38KMX0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_362678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793452">
        <property type="protein sequence ID" value="KAJ3782805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMX0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041449533" evidence="3">
        <location>
            <begin position="23"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="480" mass="53505" checksum="100504E4C3953826" modified="2024-01-24" version="1">MRIRLRAIQAFLLFFLLDFTSATFKDIDAPYHTDQDVSMAESLKSHSPLDVEKYPVAPSGLELEQVHIYVRHGERTPVGVRLAGPPANLPEHWMMCKTARRLQASVNAPGIDGAMDEFQQSRKMVERADGTHKEGQCLLGELTDLGRKSTYSFGTSLRKLYVEKLGFLPDLLQNAGEVYFRTTNVPRTTESLQQIVHGLYPSSKCHSEAIPLIFVRNGRDENLLGNAGSCKRLEILLVGFAQAAASAYNHTLEPLDKKISKYLDGHPIRIDGKPRASGILDTIRAATAHNVKVPPEFEEKAVIDVIEKAVVAECLLTSESLLDKTEEVRRLGMGRLLDDLSTKMQHKVLNRDKDPLKILVHSTHDTALAGLASTLDVFDDKWPQFTSSISFELFKSTPTGNGSSFLQTLISPFRSKASPEHYIRMRYQNKNMILPMCADEGKHLPGSPEFCTLTAFRERVKELTPLDFVSECAPAGRNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNG2</accession>
    <name>A0AA38KNG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_36138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="168"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="286"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="386" mass="40423" checksum="3B74B92E681EEA00" modified="2024-01-24" version="1">MPDADTNRKRSRSPSDSEQQKQHKRANIGSSNPLEESASTPPASSDNHAAVAKPDAEPSKSSTATTSAEPSVSSSSAAALPPPSAMIHMRCLIVTQDASIIIGKGGSHVNEIREKSGARVMVSESIPGNPERILNVSGPLDAVSKAFGLIVRRINDEPFDVPSVPGSRAVTIKFMIPNSRMGSVIGKQGSKIKEIQDASGARLNASEGMLPGSTERVLSVAGVADAIHIATYYIGNILIEAQERMPSASGSSYRPSSNSRRPSSTTGSTPYVPGFSGYTAGNPSPQLQTQQIYIPNDLVGCIIGKGGSKINEIRHMSASQIKIMEPGAVGVSVAGAPAPTGGEGERLVVITGQPANIQMAVQLLYHRLEQEKQKQLRAQTSPSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNR1</accession>
    <name>A0AA38KNR1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_360395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793412">
        <property type="protein sequence ID" value="KAJ3783600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNR1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="313"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="562" mass="61867" checksum="6ADD3D0FBC92DF47" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNY7</accession>
    <name>A0AA38KNY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_390752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793581">
        <property type="protein sequence ID" value="KAJ3781266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="187" mass="21015" checksum="898CB59ED6BC1DBC" modified="2024-01-24" version="1">MDTTPLVVLQSPPVLFYIINLSLSNMSSVFEHTESIATHPAPALYVPVHKRTTSRGGASSRSTTPTSEHESSIESSLLPIYSIQDLLMLAESPMTYSSAEQRDHLKDVAPEILLGRRQRKALEHQRHVWRAKRAETLRSSRKASRETEAREEHDRRIELEGSQDADDICCGISLATRTYRDGMNNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP76</accession>
    <name>A0AA38KP76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_14153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP76"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041244205" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31129" checksum="637543D04654FADA" modified="2024-01-24" version="1">MLARWLYLCHISTLLFLYSSSIISCLAQQGESLQNISIANTSPQIDYTPFVCNVTDSESFSTSCLGGWQVLTSEGQTVVSTKGAGPLGANVVPQMFLQFRASALFLSTSASSNATFEIAVSAGNTSVSVSANSSIGVAAVLNLPENETTTLSLTFTPGQIASHLDIGNITISVIDNSSLPSILPTPTLPPTVSLPSFISSTTTVSSTSSSPTNSSNSQSSDSSHKQLVADAVGLTVGLGLGLTLVTSLGYYTWKRRRRRRDETEWRPTGDTQGQRTIGLRRRTDNQDSTRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPX9</accession>
    <name>A0AA38KPX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_332821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="175" mass="19491" checksum="43B85A7EB852E024" modified="2024-01-24" version="1">MKTDLPPSFPRHLPRVPDASSDNAIFDGEVLEQMREEGEEAEPCDLSTGRAIDSTEHDVANAHAVIAGQEAALWKYKCNKKAQKANALKHIHTNSRVVTSEEGQQEIAEDAAVKAAKRKAENEKLRKKKDLERADILHRAEQEREQIAYTGTLKSQKTKANLVDIAFSLQLPVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPY1</accession>
    <name>A0AA38KPY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_376298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="238" mass="25890" checksum="EE6A64A8C6E68E20" modified="2024-01-24" version="1">MASRLAISSLKAAARPRVAAAVPNAFSSRSMSTSNPPPSERASEIINKLPSSPNLITKTGTALLGTGLAAAAISQELYVVNEETIVLVGSAMFLAFMAKAMREPYVNWAESQVQKIKGVLDAARAEHTQSVKDRIDSVGQMKDVVALTQSLFALSKETAQIESEVFVQRQKVAMASELKSVLDSWVRYEQQQKESEQAELTKAVIDKVLANLKEEKTQRDLLLSAVAEVEQMVKNKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQC8</accession>
    <name>A0AA38KQC8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_317526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793439">
        <property type="protein sequence ID" value="KAJ3783051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQC8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="416" mass="45037" checksum="F0853A646EF78B1E" modified="2024-01-24" version="1">MIVDKMKDTEEAPPAYEAATTSSSRSAPFPVYNDSKIQASTPSPVSPPISPSSPSFSSKGKGKAPTPNSWWSFGSSQTAREIRTTVLGIVRDLVKVKSGNAVAAKSILESCAEACSGYSLSLSSLLQEKSIESHIPLYWAIINRPPDKSDEAINGTSDLLTTLLSYTAPLSPTILAEVRQACLITDDQLLFQRLRLSPEFASLSGTDEMLIGESMIPDDVTVENLLGDEGAFAVNFRIPHFQKRMRVSSEVAVEFIARGRLWRLALCVADRRRSRHGGPSPGAWCIVLSLMENSSPTWIDSRLLIPDVSSNVSAEEVDLISNDPPPPPSMFSGILGDRSKKAAISMRIQSKLELCSSQTRPNHNRQTEIVVPLDTVPLASSIQHAGSSFIGADESLSGRLEARLRKPQGDAECIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRF8</accession>
    <name>A0AA38KRF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF427-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_347970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRF8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF9">
        <property type="entry name" value="BLR5716 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="254" mass="29287" checksum="F822A92F49993903" modified="2024-01-24" version="1">MSTVPTFVPPQLENTHIEDCPKRVRGFFGGVFIVDTRKAKLVWEHKWYPQYYFPNSELPSKFLDDGSKQVLPDGPTRYDILVGDERAPGAVLVYGSSNGDLAGLFKIVYSSMAKWFEEDEQVFVHPKDPYKRVDVLQSSRHVRVEVHGVEVANTHKPRLLFETSLPVRTYIPQTDCKLELLIPSDLQTSCPYKGVASYYHVQTAPDRRADNVVWWYRNPNVECAMINGYYAFYDEHVDVWVDGEKQPRPKTHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRP9</accession>
    <name>A0AA38KRP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_350049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3787005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRP9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="449" mass="48907" checksum="AA5D76C55D493BE8" modified="2024-01-24" version="1">MVPFEATEEEDISVTIECNFIVAGVSGQAPIIKGRLWGQVDPSASSWQLESQPHQFRPSRERTMSTTSVTSATSTSTHSSFAFISDPEISSSFAASLENRDASPSPALSSSPSERSSALHQNLSAASHRLQPVSPRHRGYTGKLLTLHLEKSQTVIWPSLIVGPAPDAVSSVRYLNTTVSAEIERQYNMDPTSLTLIALELIDIRKNKEEAFECFVWVISSSAKFLIDELLSFRRAWHLARAPMATMKLVSCYFPIYPSFDIPDNHEDDVQRGTLAYYLQCIGGRPGLAQLYIEAGMLYLEGTASGLISSSHSSLSSIRMPLPPYGSAALGHSFSGTEAWRRDRTAAARLFERARILQPGLETPMLPLSGPGSTEELAFGMHNRRRGGKQQEDLVKAEEGGRSLVGKAADVVDSTWYMLPGLVGAGTALVVVGVVGVLSFSWSRRNQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRQ4</accession>
    <name>A0AA38KRQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_373402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="143" mass="16327" checksum="B66B08C04A726090" modified="2024-01-24" version="1">MPKNKGKGGKNRRRGKNENDDDKRELVFREDGQEYAQVIKMLGNGRLEALCFDGEKRLAHIRGKMRKKVWINQGDIVLLSLRDFQDDKADVIVKYTADEARNLKAYGELPENAKINETDAFGEEDGECTFEFGDEGEVDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRX0</accession>
    <name>A0AA38KRX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_356048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRX0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33291" checksum="0270A796D34DFFE8" modified="2024-01-24" version="1" fragment="single">MSAPVLSELPFDPSSLPVAQLESLRFKANQIIESIKALQLTIDFHPAAISSWPDILNKYNLLLSQTHNFSSSLTITFPSNANTNGATVNGAGASPSSKSSPFEKIALHPRLSVTDIQLDTEIIPLLRNQQTTDVLNLENETVRRLSKHMVTRGLVGVLNGVPVPPSQPQPHSSGTSTFGSAFSAPHLAHRKPEYEDVLQECEQIRADHDRRADRAVRAVLLLRDKFEWKPRVAVELEEPEELSWDPTGRRASTQMSAEAEEEEGADSEGEGGSSDEDEVEDHLVQDDTELVAPTQADRDEDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS48</accession>
    <name>A0AA38KS48_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_308928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS48"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="496" mass="54888" checksum="F50245F2456D2D6B" modified="2024-01-24" version="1">MALRDASVVVIETGRTVVRAGLGLHELLKTPSVIIQARVGLRKNASNINDVQPNYETAKNSASSSRASSLPLIAPPNASANDYLVGTQLDDALAAGQDIAISWPFADGDVRDWSQAEAIWKYVLFNQLERRRAQNESPVLLSMYPGLSRDTYERTCQVFFERFNVAGFSILERPLAQLYSTTSLSGVIVDIEYDRTDITPIYEGFIQRSACDTIHLGIRDCQNYLVHILRHSNPSLIKTLFPPDSETPNEETIEETLLALVKQILQEGYIKVPSDGETAIPDDEGVTDIAAIVVAGKEKAIIESGMKKKANAKASAAEQARAREIEALDLVTIQFRDKSVTLGKERHRLCEPLFDPTLLNGINKSKNSVSLQDAVGRAVRQTDVDMRQYIWQGLFVTGDLTRHVKGIAVALQSRLSPFIAQPELQTDVQARFIRILYLPDYYPEYRDTGEGFAAFLGCSIVAKLTFSDIHSKTFVSKADYSQKGPHAVIEMSPALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS74</accession>
    <name>A0AA38KS74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_330569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS74"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="499" mass="56320" checksum="821FFFC9827F5089" modified="2024-01-24" version="1">MVSPLVILIASLGVAALALVISLRVRRNRLDTAKLSYPPGPKVAAMPILDAWVEYRNWGNIYGDLIYLPEWNTLITNNAEVAVDLLEKRARIYSDRSMTPIMKLCGGENLLSVECYSEKWRRDRRVFQQTFRQAAVSQFYPSQYNKVHEFLRNLVSAPDSFLDHIQRLSQGLVFKSLYGLEIGPEDPLAKKAISIVGTFARALLSGGFPTYELFPWLIYLPSWFPGCEFKRVAAQCGKIVEEVDTVPFNIAMNNLKDGICTSPIAELAVQKPEDLQEIKAMGTMSFIAASDTTMSSISSFLLAMCMHPDVQAKAQEEIDRVIGRDRLPAFEDRRSLPYVEAVYREVMRLDPPIPLGFPHVSTEDDFYRGYHIPKGCSVVANIWAINRDPNVYSEPDKFMPERYMNSPMGPFENIDNIYAYGFGRRVCAGRYMADNTVWLTVASVLAAFTLEKTKDENGNEIPITGEMTDLFFRHPRPYQSSITPRSHLAGELVLATADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSW6</accession>
    <name>A0AA38KSW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclohexanone monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_346118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSW6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53674" checksum="EA8E95F9DBB15599" modified="2024-01-24" version="1">MTSPNLILDVLCVGAGFAGIFELYHLRSLGYSVKVFEAAEDIGGVWWHNCYPGARVDSIIPVYEFSDEKIWKDWSWSEIYPDWKELRRYFQHVDEKLNVRKDIVFNRRVVSAKWNADEDRWLITSQDGFVVSARFFLLCVGNNSKIYIPDIPGLDRFRGVCYHTARWPQEGIDLDGKRVAVIGTGASGVQVIQDVAPRASQLTVYQRTPNIAFPMRQKSIDEETLRKMKQKVYSMIHRRRRQTLGGHNFSSYPKNTSDATAEERFLFYEDLWDRTGGLQVFSANYQDIRWNRQANDELYEFWRSKVLERVQSPRMQEILAPKIPPHPIGAKRPSLEVTYYDTFNLPNIELVNLTQDPIVEITENGISTADGCEREFDLIILATGFDAMTGGITQIDIEGTNGISISEKWAKGVRTYLGMMTADFPNMFFIYGPGAPSDANGPTSIVSISLRAFRSSDALNLCARPKKNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSX8</accession>
    <name>A0AA38KSX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">deoxyhypusine synthase</fullName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_346233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSX8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="357" mass="39691" checksum="1D0152850D2D62AF" modified="2024-01-24" version="1">MAVPSSASAAVLVPSEPISSDHISVQGPNFGKPLSLQDFFHSYTRIGFQATSLGNAIDIVDRMRKWRLSDEPLVEDEDDEYKSAEVRSKTKCNIFLGYTSNLISSGLREIILYLVKHKHVAAIVTTAGGIEEDFIKCLGDTYLADFHLDGADLRRRGMNRIGNLIIPNDNYCKFEDWLTPILDTMLAEQKETGKVWSPSRFIRRLGKEINNEESVYYWAYKNDIPVFCPALTDGSIGDMIYFHSFKNPGLVLDIVQDIRELNEKSRKSRKAGMIVLGGGVCKHQIANAMLIRNGADYSVFINTGQEFDGSDSGARPDEAVSWGKIRADAETVKVFADATLVFPMLVAATFAKDVQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT03</accession>
    <name>A0AA38KT03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_280127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794035">
        <property type="protein sequence ID" value="KAJ3779952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3779952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="243" mass="27483" checksum="0CAC4B6ECAC8FA55" modified="2024-01-24" version="1">MDQVDHLFTPAYHLDEGYYNTTHFEPQSFINPPEPVTSSQVDEEPLYVNAKQYFRILKRRIARARLEEVHRLSRQRKPYLHESRHKHAMRRPRGPGGRFLTAEEIAAQRAGQDGEAGPLSNTNAQDTDEEMAGNDHSPPTELSEQQSPSELQPQHIHSHEDNIPDPIRILNLSHSSAPIHHMQHNINVPLPSSVPIAVSPQAMYIQQQPQHSLPQSNVDGIASSAPVTLTSPYPYRMVSLYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTC0</accession>
    <name>A0AA38KTC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_344517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTC0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="55"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="577"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="740" mass="79245" checksum="EF17D063DCB44015" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTK5</accession>
    <name>A0AA38KTK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="170" mass="17886" checksum="A4A87401FB203F32" modified="2024-01-24" version="1">MPVLSDLSLHSPSNIVGTPFTVNSVPYEYPFPPNAHSSDATFPPLTPPSLLSASLSLSGPTVALSTSSPFGPDARSYSPTHPKMRPVDPPVPPGLVKKRQRWSLTLTRRENSFGSQTSEGSTSSGTGTRSHRAFSLDDAPPTVPPQATLPERTSSGKTSPVPGTADDNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU41</accession>
    <name>A0AA38KU41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_299497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793549">
        <property type="protein sequence ID" value="KAJ3781527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU41"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="32801" checksum="83E37BE90C928B96" modified="2024-01-24" version="1">MATSTQSKPVTGVPIEISSVSEWNSILRHAYANNQTVIADFHAEWCQPCKVIAPVYANLASQQPFTYFLRVDVDGNRTRPIAAKYSISAMPTFVVIKRPPGEEVTENETGKGVVVDRLQGADAPGLARITNTHASRAYTPPSTLQTREAEKSKDIGNDLFKKRQYAAAVDAYSKAIELSPNSGVLYANRALAYYKWIQSNRDGADSPEARNALRVKQMEDGLKVTKLEERWGKGWVRLAEAFLEAGCEESMAVDQGLEGRRHNLEAAEEALTSAVGLSEGKAKAEAQSALETAQKAIAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU91</accession>
    <name>A0AA38KU91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793526">
        <property type="protein sequence ID" value="KAJ3781767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU91"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="198" mass="22432" checksum="6F2726C6477FF20A" modified="2024-01-24" version="1">MREEQLKSTFFNHIVAQGARFMRHDRSTQNALEIITHILTLTPTDVQIQEEIRIGGKGLEDTAAGSIHREEVERVLAKHKQEIASLGKEIDTIKHDNESLRRDLLKKGLEDSLKSRGQLEDQYKSVDVVRSATLELLQVQLEDKKATTVVAQVREEIAVQRTYEGNGNGEPLYFPHEPVLTFLQTSFSLPIPTDILHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUC9</accession>
    <name>A0AA38KUC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_346127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUC9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="302" mass="33157" checksum="F5733E8B1A0CB148" modified="2024-01-24" version="1">MFSSASSPSSSSSSSTSSTRSSPVHHASLVDPSTHSPALLQLIDIQISKQFIDHVVDCVADTVDFAMGRPSHPRGRTPSRRPELSKFTTFVTNVLTRAEVTTPVVLASLAYIDRAKPHLHIALEEWAFERVFLGAVIVASKYLNDSTLKNVHWAMCTGVFGKRDVGRIEREFLDVLDWELNISEDDVLSHHAGITTFISPSPPPRHRYHHHHNTSSHHHELNRHPVRSHDRSSCPDLEPSSPVSSDGSSSPQTPSTLNNSPESFAPVKGPIVSAHPDSSLGDILRSFPIPSHHTSSQIPIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUK6</accession>
    <name>A0AA38KUK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L18e/L15P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_92550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="85"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="244" mass="27185" checksum="37C0F9634EEA6C28" modified="2024-01-24" version="1">MASTASRSRISLANLSPARGSLHKQKRVGRGQGSNHGGTAGRGHNGQKSRSGAGIKPGFEGGQTPITKLFPKRGFVNQNERVWAPVNLERIQHWINLGRLSCSPEKPITARELLLSGCIHDIHDGIKVLGDGAEFLTSQIYITPSRASKSAIRAIEDRGGQVVCKYYNPLALQDCVKGRTDRITAAPTRRQDIMWYSKFQNRGFLSPDLLKKLGDAPFVEERWKLLSQQLGKWRKQEFDVEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV87</accession>
    <name>A0AA38KV87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_334602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793411">
        <property type="protein sequence ID" value="KAJ3783627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="118" mass="13821" checksum="D325023C9DB8F19C" modified="2024-01-24" version="1">MELDMAQLFVVVIIEAIMESFLIIPSRRRLIRAWQLIKEKREREREREREAWRCTNDGKNSKDENHQLGGGDELHIIIFGNELKLSGCRTKTQKEVRVFVSSQLEESSTSKALYNSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW63</accession>
    <name>A0AA38KW63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794094">
        <property type="protein sequence ID" value="KAJ3779888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW63"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="223" mass="25374" checksum="3E66C397E4F261A6" modified="2024-01-24" version="1">MQHRRGCYPTKLFGISFGGGQQQPGNFNHPNAEEMIWEKVRNSAEIQALAPPDLLACYFPKLHSLYSNVLSDLCLSNPHLRRNWPDCCFAASSLNFEHAVTTRHRDFRNLLFGECAVWNGGLFDYKKGGHLIVWDLKLVVEFPPGCTAFLPSAMFAHSNTSISTNEKRHSMTFFSASGLFRWRHNNYMSDKDFMAGAPRAERLSWEGHRDALWSTGLDLLSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWB9</accession>
    <name>A0AA38KWB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793866">
        <property type="protein sequence ID" value="KAJ3780188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWB9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041362279" evidence="1">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="100" mass="10868" checksum="962F60AAD6902047" modified="2024-01-24" version="1">MSPNAFSSCNLLHFSWASCLAAERNTWSSASSSLMTGVGEWAGQAGDEVVDMKKQENVEVQLSQGFLYALADVITCDDLKTNTPDQTLTTQHSFDTFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXC0</accession>
    <name>A0AA38KXC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_276912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793525">
        <property type="protein sequence ID" value="KAJ3781778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXC0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="113"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="11">
        <location>
            <begin position="371"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1088" mass="122802" checksum="16D6B3E499C14263" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY89</accession>
    <name>A0AA38KY89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_426029</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="131"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="236"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="468"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3788772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="617" mass="68020" checksum="0D213AF7DFED43CD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYA4</accession>
    <name>A0AA38KYA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_384659</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="5"/>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYA4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="16">
        <location>
            <begin position="215"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="660"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3788847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="704" mass="75512" checksum="327B9379C517ADC1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZH4</accession>
    <name>A0AA38KZH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_354246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33305" checksum="294AE891D3C886C1" modified="2024-01-24" version="1">MASSQSKTISPDKLVMNENELAFYQRQTGIQDKNKLKEHIIEIAQKALQVYPYHCIHTFGFLRFRILRAESGYKQLLKLGSTRPNAFFLDLGCCFGNDLRKAIEDGFPARNVVASDLRADFWSFGHDLFHSNTSTFPVLFIPGNVLDSSFISIQPPLQFEELPSDFSSVSLQSLLSTNSESQSLNSLRGYLSAIHTSAFFHLFDKEEQILIAKKLASLLSPLPGSVIFGSQRGADEPQEGARNSTGTLYYRHSPETWKEMWEKDVFGGKVDLIRVDAGLSLDEGREIIWWTVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0F7</accession>
    <name>A0AA38L0F7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_307757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0F7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="164"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="469"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3788138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="567" mass="64319" checksum="4B7D1CA8B34CBEDF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L463</accession>
    <name>A0AA38L463_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_362325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793444">
        <property type="protein sequence ID" value="KAJ3782950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L463"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041294941" description="Molybdopterin synthase sulfur carrier subunit" evidence="3">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12615" checksum="050BD3160C26A263" modified="2024-01-24" version="1">MSFSAHITVLYFAAASTTLGITDELVPIPEKGLYLSQLTELLIERHSQSSLNSGTTGTSEGDRKKGNNEGQAVGEALRKILDSSQWSIDAEMVDDEDLTKVELKDGMEVAVICPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4Q7</accession>
    <name>A0AA38L4Q7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_40924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4Q7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="643" mass="70542" checksum="9AFD6DF60A6AD836" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4R5</accession>
    <name>A0AA38L4R5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_272455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4R5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="140" mass="15832" checksum="F14791C2CF4101E0" modified="2024-01-24" version="1" fragment="single">NPQSEAVRQNFLQLRNLTQALPGGSIGSKIATISENQVWLIFTRVSSVGLNSWTPNFLGSVSSLWNELHESITLDTFRQACMNHAYETFGVEMKFVLNSELAIGLYCNFVFHHLLNNIRKEQKNPGAVQKELDLSKVYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4V5</accession>
    <name>A0AA38L4V5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trafficking protein particle complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_394773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4V5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="6">
        <location>
            <begin position="709"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131621" checksum="889D19E67E7F0147" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4V7</accession>
    <name>A0AA38L4V7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="3 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_235738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="3 8"/>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4V7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="89" mass="10426" checksum="B5E382201B3041C0" modified="2024-01-24" version="1" fragment="single">LPQDAAYTPYWCEENVYLLIQSFSQNPSLSEIWEVFAVFISNYSKTAQPGQPVVWDYHVVAILRPRKSSSNLHSWVYDFDTRLDLPVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L589</accession>
    <name>A0AA38L589_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_160385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L589"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041464884" evidence="3">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="192" mass="19741" checksum="73C273914AA4C20D" modified="2024-01-24" version="1">MFNAKTSISAALILSSMLHGVTAQVTTRRRRTSVGGVVAGIVVGCLVLLALLVLCCLLSRRRRRLRNNPAGFAGGPGAGNYNGRTGGRPYFGNGGMFAFGNGKQNYNQNQALPQHQQPVGGAQYGYGNNDPNSYAGQNGVGGGEVPGNANQTASSPPPYGKEGAGYAPPPGPPPPAHTTGAQNDQFVGGFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L596</accession>
    <name>A0AA38L596_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_386221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L596"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="467"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="588" mass="66469" checksum="AD64E129F63CAF05" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5F9</accession>
    <name>A0AA38L5F9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CigA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_416773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5F9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59921" checksum="42F1CD5A0AD9CF8E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L635</accession>
    <name>A0AA38L635_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_104971</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L635"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="20">
        <location>
            <begin position="256"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3788542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="627" mass="71611" checksum="ABADCD7DBD4F5DEC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L650</accession>
    <name>A0AA38L650_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_168844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L650"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041396195" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18621" checksum="5BBC068EF07B139C" modified="2024-01-24" version="1">MLSDILLYLMPSLYCFSSCLAVPAPNDLTSFPMASSTRSISPTSTVSGLSSTTSIRVFAVVDSTHSSASSYHLSPAGIFFIALGGFFILIAISTAFVRFLQSRGHSTSATTSAALQSADPRTDDGKPCKDLLPPPPYTSPPPDYSAKDSGPSQFDPVTLTPVDGGQHVHRTSSRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6J4</accession>
    <name>A0AA38L6J4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_308678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6J4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="381" mass="44952" checksum="3B980EA1F9B66AFE" modified="2024-01-24" version="1">MNMTLRYILAVFGAVITIHYVLSFTHTEYGRATSLSHLTSHFTGVNPVDITPIPDRYFPPFSNDTLSVDRRANATFVILARNSDIDGTVRSIREIEDRFNRRFRYPYVLLNEEPFSDEFKKRVSVLSAAKMEFGTIPKEHWYQPSSIDEGKAEAGRNSMVEQGIIYGGSVSYRNMCRFNSGFFFRHPLMEKYRWYWRIEPDVHFHCDIKFDPFIFMEENHKIYAFTIAMYEFEKTIPTLWGHVKDFIKLHPQYLAKDNAMGFLSETGGDTYNLCHFWSNFEIADMSFWRGEAYTKFFEYLDQQGGFYYERWGDAPVHSIAAALFAPSNQIQFFDQIGYEHNPYTHCPRDENTWKDEKCTCDPKRNFDYDGYSCMSKWDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6Q1</accession>
    <name>A0AA38L6Q1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_128245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3788020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6Q1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF2">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="74"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="915" mass="99336" checksum="E39233944A48F85C" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAV7</accession>
    <name>A0AA38NAV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_338017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794903">
        <property type="protein sequence ID" value="KAJ3779446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAV7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="18482" checksum="A92EE068E674D966" modified="2024-01-24" version="1">MYNPVFTDIPFFICDSPVPSNDLFCPDATKELVFMAIVTVFLLGLVVIMMAIIQGVCFIAAQAYTYLAKYNLCDKENVHKRREQAVVLRELAVKQQERTLQMDVEIKVCERLTQILRRSSASTQERAHELEVEKDLLSEIAGCGGDTSGEGSLIHRMPKSPIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBI9</accession>
    <name>A0AA38NBI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_367361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793583">
        <property type="protein sequence ID" value="KAJ3781246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38058" checksum="0BB632390AD4A922" modified="2024-01-24" version="1">MKDLLRAQSRHGQWGGFLRIARQAVASELNRYTIGQEFSTAFADLVQIVTLKAIVVSLLDPDRDMESIDAQDLCASATLITELWAMSKQQTSVSSAASSPSTCTPPDVDRLATLSTHLRRLLPDTERYPNPIDFVVPTWETLWRLVATSLAHVYDNKDYRHNFHELLGDPTPGRFRTTSLDSNLCTEWIINETLRLHPPSRHISRSFPLVKEHPGLQILVSLLPKFIRDRLRLDSIIRSEIADIESVHLSTDIWGPDALEFKPRRWERHAGAADSAPTLFAFGYGPLMCIGKNWAPMAAALIVGAILEGIDAEGLEIIGTAVIGGRAGWAGWEFKHPEDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND12</accession>
    <name>A0AA38ND12_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_312431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="264" mass="29749" checksum="594D773DBBE9315A" modified="2024-01-24" version="1">MYLREIHAEHDVPTLHGFIRENPLGIFTTAIDSTHHPFIQSSHIPWVLDLNDNEDGIDYLGTLRGHIARANPQAKAILDSLNELGSTDGPGKLEKQVMVLFTSSIHHYVTPKFYTETKPDTGKVVPTWNYAAVQLYGEASIYHRTDDEKTSEFLDRQISDLSNVGEKQVMEIMQSASEKDDERWKEPWKVSDAPPRYVELLKKGIIGVEIKIQSIDGKFKMSQEMSKGDREGVVAGFMFMGNEVANKLADVVKQRGELADAKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDP8</accession>
    <name>A0AA38NDP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNF2-family ATP dependent chromatin remodeling factor snf21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_426705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDP8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="198"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="645"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="565"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="908" mass="101746" checksum="94EFAA1C2D4C6DA6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NE30</accession>
    <name>A0AA38NE30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_262769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NE30"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="182" mass="20396" checksum="9D96741BB87F649C" modified="2024-01-24" version="1">MSRWSQYDEDSYRLPEGMERIGYDSDTGRYLFRDGDGSTWQGPEGAEYGEMTRVSAPDEAQEAPMRSDGYQQLATDNTAPLAFRHRVNSNAYRTLAPFFLLIGVILLLVWKFTSYEWSPPLSPCSANATSPYMVQPGDYCWEIARAHNCTLEELESLNPEVDCSTLRPGSTVCLPKAVSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH35</accession>
    <name>A0AA38NH35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_338015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794893">
        <property type="protein sequence ID" value="KAJ3779447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH35"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="140" mass="16284" checksum="C99CE58A1703A687" modified="2024-01-24" version="1" fragment="single">CTSCAQRRIKCADNETLAARNARLAKGEKSSKRRGKKEEEVEEDDEEDNEMVHLPKGPRLGHRERYPRGAQSLEDRILIENRRIGEQQEMTLRVLDRMEERQERIENELARIARMLEARENEANEGSEGEGNEGKNHEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHH5</accession>
    <name>A0AA38NHH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_368944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793677">
        <property type="protein sequence ID" value="KAJ3780662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHH5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="159"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="321" mass="36892" checksum="15F80CE2D51B76B0" modified="2024-01-24" version="1">MSATTDVSHQSDIAKMKTEADGSFKRLDASFRNFIQKGGQFEAERDRYHLYVSYACPWATRTLIVRKLKGLEDFVSVSVVSPRMGTNGWPFASVDPFPGADMDPLYNSQHIKDLYLSVTPNYSGRFTVPVLWDKKDKTIVNNESSEIIRIFNTAFNHLLPKEYAEVDLYPDSLKAKIDELNEWIYPNINNGVYRAGFATSQEAYSTAVKQVFEALDKVETILAGDKKYIVGDQLTECDVRLWVTIIRFDPVYVGHFKCNIRDIRNGYPSIHKWMKDLYWKNPAFKDCTNFDHIKTHYYWSHPSINPTRIVPVGPVPVIQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHK1</accession>
    <name>A0AA38NHK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_300329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793619">
        <property type="protein sequence ID" value="KAJ3780977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHK1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="108" mass="12192" checksum="599775AD7E5216F0" modified="2024-01-24" version="1">MPPLFSGYLPHILYSVANVSLSLHLVYQRNTFADEKARANAQESILQSIANELRSNSPLSPADLQRLRRLARVPVHKEEDTVEQKISWKDALLGRSNYRRSADTGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIT7</accession>
    <name>A0AA38NIT7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_234375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794524">
        <property type="protein sequence ID" value="KAJ3779614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIT7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="76" mass="9212" checksum="CECD436B8A56D82D" modified="2024-01-24" version="1" fragment="single">LTYAKFEQAAANYYRFEMERDPEGNAGNRSTWTKSHFLFWTNCSDAEDTFLFWKPLELEMRQARQDRNLQFDLNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIV2</accession>
    <name>A0AA38NIV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794339">
        <property type="protein sequence ID" value="KAJ3779704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIV2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="225" mass="24436" checksum="91634EB97EEFEC81" modified="2024-01-24" version="1" fragment="single">MPVSGDEVQELVAQCQKIVEDANAGRISFEDAADTLKKLGVSGSVLKSYLVQLQGPRDHQDQRDRAPEQDDRSKTPDGLDDSQRDEFRRNRDAVLGNRGQNGGGDGQGVGTGVQGVGGLSGMANSRSEDASDFHASASFLQQLKAIQRFAGIDSGSISSSTLESLPHLKDMATSSGDAHVDETLRVKRVYVKEQNLDALVDLFQARPLLEPLPRSVWKKVLKDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ05</accession>
    <name>A0AA38NJ05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_420070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793991">
        <property type="protein sequence ID" value="KAJ3780004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ05"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21574" checksum="12170C07DED7D203" modified="2024-01-24" version="1">MSVLGRAGCGASNWLSKVEVLGMVPSSTKTPCRDSHRDSQCMRDGFRFVLKTLNAALFPSVRSSSESSDNLLTHEAVDEENRKIENEVSVWRQQYEEAQVFTASSEHLDIIISFHTGDLICLDPISSRYHRLNKGGCVTSSACTAVRWVPASASLFLISHADGTIVVYDRDREERAGCPRVGIHIGIRIEICSACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ09</accession>
    <name>A0AA38NJ09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SEN1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_321968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793969">
        <property type="protein sequence ID" value="KAJ3780034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ09"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1211" mass="137757" checksum="36C4B280B178E41B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ81</accession>
    <name>A0AA38NJ81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_254181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793610">
        <property type="protein sequence ID" value="KAJ3781053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ81"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="173" mass="19617" checksum="A94FC50D3849C74C" modified="2024-01-24" version="1" fragment="single">MNESKTARSFGCFEVNGLFAGFCCHSFVLVFADMLRTGEQSKYFLALLHHFMSACRDDQRQHGLPNEPIGSLGVGYDIACGMVDKITRSPLTQLAQDEKLHLLIGLLHGYAHNCLCQLSFLMLYIYGAGIEDLEVCERFFSHSNALASVTRHMSRFRRHQAIASYAYHRDNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJA4</accession>
    <name>A0AA38NJA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDF zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_415982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793726">
        <property type="protein sequence ID" value="KAJ3780484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJA4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041394871" evidence="9">
        <location>
            <begin position="25"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="31"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="259"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3780484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="390" mass="42712" checksum="D70DFE8F2D891AF1" modified="2024-01-24" version="1" fragment="single">MKSIHRLALVLAISAAFFVAEISGNCEQHPVGFKTKSIALIADAFHYLNDVVAYAIAFVAAYVQDRGHTVRGFTYAFHRAELVGAFFNGVFLLALALSIFLQSLERFIEIEQVQNPEDVLIVGCVGLALNILSVLFVHDHGSHDHGHSDGQSAISDAIALSDEIMLVHAGHHHTRTKPSNKHSHNFGLLAVLIHLCGDAVNNIGVIISAILIWTLKSSNRFYADPTASMLISFIIFGTAIPLTARTGRILLEAAPIYLDLQKITDDLNGNPNVVSIHDLHVWHLSQNVILASVHVCVPFGMSLDEWENTEQILHHCFSEYGVAHATISPEVHRASSQVYDNQTQTMVDEPGDELLGTCKVHLKDGFGCIFGDNPANTMRRRDIGSSHSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJB3</accession>
    <name>A0AA38NJB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_292388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="33060" checksum="A5FF05BD16D36608" modified="2024-01-24" version="1">MSFLSPVAAIFSYALEPIAPFTWFGLRISTLDVAAAFRLCLVLRQIREDLHRKHVKSHGTTLIETRSFVRSASTALTVVFGGEALACPYLMVPPSFMVSGIVPIFYTVIQGIVDTVPAVPEMFFAMELPLSIFDGFSRAFLLCDLIPPMVTANSSSTISTSPWTLLVTSLVTANGGFFLTNLFSFMNPTPLALQTPPELQVYGWTTADLWCAPLVTGVYALLTHAQPFWAESHALLIELLGMGVQGKSVEPLDSETARAFCAFLLACLFSGRTVKNFTNYFNRPMGIIKNKVTKEPKLKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK17</accession>
    <name>A0AA38NK17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_389916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793480">
        <property type="protein sequence ID" value="KAJ3782373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK17"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="233" mass="24204" checksum="D1ECE96A0ECE5234" modified="2024-01-24" version="1">MFAAYSKFGLGITYVLLTIVSVLPAGVNVTAIPATRTITLFDVPAPTDTNMLQQPSGPTTVTSFNILGTTTSNGEAMTIYGEDIIYSEYVQEETMETASGSTSIAWSTITLSTPQTLHEIVAMGATAIEYSHSHTSIDDTEFVVDCIFSAGEISGAGLCTEVYQTSVDAPSQTTAWTGSVIPFATFGAPVSDAGTSTKSSSNAAKWLKGGQSFGLVAGYCFAALISTLAVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKQ2</accession>
    <name>A0AA38NKQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_308828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKQ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000061">
        <property type="entry name" value="TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="8">
        <location>
            <begin position="213"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="320" mass="33406" checksum="86AC50023C86BD7B" modified="2024-01-24" version="1">MSAPQVPDAPYAFNSPSPEPSAVPTVTSHAGPGRPRGSGAKRGRKPRGAILAGVASPRVTTTEMTSSTSPAFPSSTYTPHVHWNLTNTAGTSSPGASGSSSVLPATGIAQSRPGSSITSGISAYGQNLQTSSTSALGTSSGATTGIGASLNLTNLFRMSEGVGASGTGSYPRATGLGGDDEGEGDDELLPAMADDDYSAQLSWQSQSKDNLKVLMENFSPDQYDRFEAYRRHALPKQAVRKVIQQVTGQQASQPVAQIVAGFSKVFVGEIVEKARQVQARRGEAGPLSPDHLREAYRLYQQETGNVGAAKPVRAKKLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL49</accession>
    <name>A0AA38NL49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_316371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="424" mass="44419" checksum="CBCF96C0409F4A6F" modified="2024-01-24" version="1">MAILDDNLPGLQRIITEMFMFAQLARFALILFATTGALAGGIRSQKRSNDTTQCLDTRDSNSLMNRASPALSFDASQWIWTPELSGGNAPVGSRGFRKTFVPPQGKTPAFLTIAYSVDNVGTLFVNGQEISTEDVWYTAGTYCINLADCGCAVVIAFNVTNESTTPNPAGLLVAGIVTYTDGSTSPIVSDTTWRTSEGGLPTGFQDLTFDDSTWAPAVTEGANGVAPWGDVALAGSDPLSFTPARWIWTNEVSAGGNYPPGARAFRYSLTLPGGQTSGTATIIIDTDNEYSLYVNGAFVGTGTDFETAQKYVVENIQGPEIVFAVYAVNTNTVPNPAGLLAAIQVTSQDGYCTQCISTSSAVTFAGWKAFPGPVPSGFDQPGFDDSTWPVAVDEGAYGVAPWGNVPVPTTVTTGGTPLPGAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLB4</accession>
    <name>A0AA38NLB4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_384891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLB4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1158" mass="130877" checksum="97A32D9C0A5886D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLN5</accession>
    <name>A0AA38NLN5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_333526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="437" mass="45359" checksum="B818DB290B5E16B1" modified="2024-01-24" version="1">MNHQLEHQARSAELHRRKAHLNRADILDPLEAAATSVTTTSAAETTTTSKAADSTTTSQSATSTANTTSATTSVTTSSSKSSSATTSSSSTSSSSTATSKGTSTGSSTSSTSTQAATTSAANVPVASRTVATYVTYTPSSSVTGTAAVASSSTTTTSGGVSAGSIVGGIFGTIGGILVVAVIVAFIVRRIRNRRRDDEHFNAAQFRNSAVLIDDEFGNDNFSARPPTMIARHMANAPAAPPVTYGNYPGADPYAPGDPFTPIEQFHPSGPYGHYNAYPTYTQEPVYTLQPGETFVHNNPIAPSGSAGSAEEMDPTTAHNTYLNRQPTLRGPDTQSTDVHQQQYLNMNRVASPPAMAASADYNTGIPSPTSATPLYHPQSSAEHSSVLPMQNMYAPIQYPSVGAPAPAAAATAPAAHPQDAQRRPETVYDPEDAYGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM64</accession>
    <name>A0AA38NM64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_386971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM64"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="326" mass="36311" checksum="F28E283F1BF5475E" modified="2024-01-24" version="1">MTMPDSENANLSTPTCWNYVRGHCSYRACKYYHPIDISFPPYHRNSPFASSKPLPLLADDWVDGNDSKDWRQATHTTSTVYTPVAWKTAPCKHFTLTGSCSMGKGCKFIHDQELVHSSTDARGNGHLLQVTTAPQAWRAHCWSFIQGQCKNPSTCRYFHPSNPEAYRKYTPCLLWPKCPSGDRCSFKHSKPMHEQPQPAASNRRPTFTPSAGTASPIEPPFVIYDSLESRPLASLTSAPYSNCNSERDAAKYRHPHFSASHYSLGVLPAPSAYSGNGAVFKTQTANLPFNEVHSKGLESSVFRPGHARRISVAVRRPDTLEATAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMU9</accession>
    <name>A0AA38NMU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMU9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="169" mass="17993" checksum="002B9552122F829E" modified="2024-01-24" version="1">MSYVSSHAGSAIYPGSSAPSVVLPGSNPSGVVYPSSPFPGALYPGSSASGAMYPASTPGVVYPNVSYSSHGHAQHVAAPASYYNHHTQHAYHSVPMQHNFYGAPPVAMPSYVAPPAPAYHRSSYTVPYSVGMPYSGYGSPQPTIIVTSRSGRHHRRSSSSSSRHRRYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPD4</accession>
    <name>A0AA38NPD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_376833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793381">
        <property type="protein sequence ID" value="KAJ3784310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7330" evidence="3">
        <location>
            <begin position="614"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="815" mass="90176" checksum="79FD80804F7B60EA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPK6</accession>
    <name>A0AA38NPK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793343">
        <property type="protein sequence ID" value="KAJ3785390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="112" mass="12630" checksum="5ED57524D195EA67" modified="2024-01-24" version="1">MSVNPEQAPISRYYSLALAILFSISLYILAPVTVFMQVLLDVFLLMPYNMVIYLVDAMYPVYVFCGVACITGVIVGVLARQLVFWLVELGRLDKAERPPEERPTEVVAEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPY2</accession>
    <name>A0AA38NPY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late embryogenesis abundant protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPY2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24004" checksum="5D6B9720A092CC94" modified="2024-01-24" version="1">MFRSQAIRAAKISSARVPALTKAKRVRVYSTEAQKPKSNNELLIGALVAAVGAGAYWYYSNPDEVARLEAKAKKDEQEAVQKAREAGGAGKARIEDAYRMGQLKFDEAKASADKTIGDAEARAKQAANDAQAKFDEYKSSASRSLSNARDSTENLYNEARVSVDKKYGEAKSGVEEKKEQAQAGWFSWLGWGKSTAEDAKKSGAEKVADAAGDVQAKANKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ72</accession>
    <name>A0AA38NQ72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_393203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ72"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="894" mass="98480" checksum="B17B486DE2E42640" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQM3</accession>
    <name>A0AA38NQM3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_260983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQM3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041237028" evidence="1">
        <location>
            <begin position="19"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="384" mass="42088" checksum="CA8685C1FE055ED1" modified="2024-01-24" version="1">MLILLVVSWISLYLNDRAKVTKLSPKDCLALHNLNDLISCLDAFTVSPGFYDAVSYAAAQPTEEENTAWTSVVSSMLDVNANDCSSIKLPSVLEHFYVVTTFSDADSTRSFCILSETTTSVNQNYTKGWGSMIVPASAKQISRRLHLSAPHPQADINTPQQAGAIFVLSGAHSLLVSGRFRSAYAMETDCIPPTQPRKRYFKTDPTHDIHEPFSIANQAIRDWQNANGGCPSETCAYVQFHGKAAASCAADTMFISSGLGNSNSSLSWYRDPSLDIPARRLRDVARTVFPTWNVTIPPDDPDCALTATSNVFGRLINGVPESNVCMTEANTLTATGEFIHIEQAIVSRQSNVYDHWGEVFKRTFRTSCTEGTVEDSETGICEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR47</accession>
    <name>A0AA38NR47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="476" mass="51232" checksum="301A2E5B7B7EAAAB" modified="2024-01-24" version="1">MLSIRPASRNAEGNTHRQPFKTPSRALAENRLGTVKGKGKAGAGQTPFQSKTPFQKPLFVEADIQLKGGVHIPARPFLDKTPFPNRIVDSSNINLQQIPFLHPASTSGTPDSALRPSSTRRHIRVPRNSQKFQTPLNTKIHWNVNDDSADGISLVLPEPEKVAALPEDDFDEIEYMPPNTLDIPYQPPFDLEMPDYKVLGKALLEASRNGTFYEPEPRVEFELSPEVIEMCDVHLDFSSIPDEDPFFEMPRKKDVNTSLSKSKPSSGLANARPIPVPSKTSLASRAGAPGFPSSGSRSTFAVNKISRPGTSTSVRPLSRPLSQAAAFSTSNSKTTVARPITRVPSVASKSTVLPRDQTRPITATATTLSRSKSTTAALRPHPVHADIRSTSSAAVSVYSKPGPKSTGTILANKPASTMIQRPASSVRPKANGSMTAAATKPATNAKEAPQITELGGSIVSLDDVEASLADDFMFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRI1</accession>
    <name>A0AA38NRI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase A4 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_401174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041466287" evidence="3">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="267" mass="28111" checksum="1864696BF36BB47A" modified="2024-01-24" version="1">MKLSTVLSGSVLIFAPLTWALPPRGLSNRGSKRHSNPSFRIEEPDTASNSANTTIQYSGNWSGAVLVSPPSGEIFNSAIGTFTVPSMPPAGSNGAAAAWVGIDGDTFATAILQAGVYFSVSGDTVQYGAWYEWWPDYATDIDTDDFPVSAGDVITVNIEATSNSEGTVTLINESAGMNFAINLTSPTKLSYLGGQNAEWIIEDYTQNGGLVPLANWGTVTFVNASASTSANNKLGLGDATIFDIEQYNDIMTSVTIDSDSSVSISYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS26</accession>
    <name>A0AA38NS26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="13">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_303749</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="13"/>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="890"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="959"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="14">
        <location>
            <begin position="243"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="475"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3790055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="996" mass="111600" checksum="94AA1FA793D7A097" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSW6</accession>
    <name>A0AA38NSW6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_340337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSW6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="201" mass="21882" checksum="C886E49E92A5D082" modified="2024-01-24" version="1">MPAPEITVNPNYPRHKVKHVNLMVDTYLANATLEDLRCAIRGLLASGTSGIASAFSAAARNHLYESGALIPPNLDSLFDKNVGNGEITPTRTLREVIARARTVYGIGLGFASLEILIPVVEATIGAKWERDGPTAEILTEVDADIVQAIQSCKEELLSDRVKERGAARQIVNRLQSGVEDSSQEGVVVFEKAADSMRHWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTP1</accession>
    <name>A0AA38NTP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_424861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTP1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="481"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="690"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="924"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="925"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="951"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1131" mass="129033" checksum="45C54C2155E8FC55" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTT3</accession>
    <name>A0AA38NTT3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_339298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTT3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="159" mass="17266" checksum="3AA600636EB52623" modified="2024-01-24" version="1">MTSVIAPQILSSSLPKSLGLESKPVQPYNELDCLEDAIQTFTQVLSQSGRSAVRLHCSIPTWDTESNLCVDLHDLNHLRSKSLVLIHDLVKSLRSSGIFATYSLAPAHSPLCLVCASSPGFDATRINTRAVSMVQNAKLDIGEHVLLANLERCPSLIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU57</accession>
    <name>A0AA38NU57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_370455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="218"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3791165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1489" mass="167749" checksum="1B25583692A73CA6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU65</accession>
    <name>A0AA38NU65_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1793-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU65"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041208257" evidence="3">
        <location>
            <begin position="22"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="5">
        <location>
            <begin position="104"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="4">
        <location>
            <begin position="342"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3791208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="873" mass="94799" checksum="A4E7FEEFCE898481" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU93</accession>
    <name>A0AA38NU93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_370470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU93"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041231121" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20179" checksum="05D75A048F51B295" modified="2024-01-24" version="1">MIFKSSKLLSFALTWTLACVQAATPGIVFPANGTQIAPGARFKFEYKSIADYSVSSYNHTVILFTEEPKIFIGSTDFAAGHTFGQFDVANFPAVPYARHPAPSHFTMPDFSQKSGPGWEIGVSISNATFYLAVFEEYSNGKHVVGHRISLSINHIVYNSTDSSDEDLSYNWEEYSKGQVVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TXZ4</accession>
    <name>A0AA38TXZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_343753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TXZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="554" mass="62602" checksum="91CF68A2780BECDA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0A7</accession>
    <name>A0AA38U0A7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="7" type="ORF">GGU10DRAFT_282184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0A7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="426" mass="46808" checksum="0A88867D07FEB04E" modified="2024-01-24" version="1">MHPFASYVLRNYYKATGWNEDNLFTNLTRSSDAILDFAVPKGLHLSISKSPNALFKTTYSMNAMPSLNGSVGYIFTSCDLNVKSSGDVRFKDMIERFRVYDQPRRPQGKGEEWLAGERVDTRDYLMYGRLYIPTGRLDALYSTRLSSNLQGILAAISDPPSPLSARANVSNLMLSLQHDVGKWCTEYTYSAEDSMWGIKALHNFGRIAGSGNAAESLQSPTQVGVKRIDEEDAVEGGLKGRLSAGAEIYFSAKEKSAGVSTGIRFSTIPDAKPPSAGGSTLVTNPPQPPTTITALFNPMLGHLSGAYSARVSTDLALSSRFDFNVYSYESEWTMGAEYWLRREDDLDGELLSSTVIPASKPSKKRIRGVVKARASTSNDVAILWEGRMRNMLISLGVIADFSSHGRVKPIRAMGMELAYFSSDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0I6</accession>
    <name>A0AA38U0I6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_339922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0I6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="502" mass="56090" checksum="9AB25D29272D0247" modified="2024-01-24" version="1">MRSFSPDLKEMVISTVPDKCISVGWSHQEERQLVRKIDIRCMPALVILFILNFLDRGNLANARLKGLQTDLNLNDTQYATCISILFAGYIFMQVPSNLVMNAIPRPRLFMALVASLWGTISALTSLCDNFSHLVICRFFLGFVEAAFYPSAVYYLSRWYTRQEVGLRIAFLNAGNMLAQGLGGLLAAGILGGMEGVKGIRGWRWLYIIEGSITVAFGLLLPFVLADYPASTDWLSNRERAIAQGRLVTDVGIIDNPEDMERSGSGAIRGIWLAISDIKVWTLAFMYFTYIMGLSFASYMPTITATLGFSTTITLLLTFPPWAFATLYALASSWHSDRAGDKFWHIAGAYGFAILGYIVALTANSITGKYVSLFGMCMGYSGGIIILGWISTSIPRPPIKRAASIAFINAFANIGQIPTSYLWPTKWGKRYWQSFTTEICLMVLSITIAFAYRQHLISQNKKLDKGETEAYITDERTVKQSADLVHISMQQEEALLHSFRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1B5</accession>
    <name>A0AA38U1B5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_301890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1B5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="91"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3791095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="323" mass="36228" checksum="0F920487C3C3203D" modified="2024-01-24" version="1">MIVQIGILPDDIIHTILDGNTVQRVNNGSFIRLPHPRTGLSALFFPHQTPSGSTISELQVVEPINTRSWFIGNEIIADGRLLMIMPVDPAFLLVPILRSVSPRNGTPGQFRTLDDIFEEAAMKLEQSSSKDSTEAILRKDLATFASLDCCKDSLTRVCDRQDLPPDIIVYRFSSNKFIDYLKLKVENLLKADVIEGSKTLMRSLAKDGLMEDGNEDLLQAGRLKIACDLIAQYIPSDLRTLLSASYDFAELDVYLEKLEEEQRLKAQEASANTRSRKKVVKKEDSKEKVDKRKAPKQSQGVEKLKKANINGMAKLSTFFTKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1U5</accession>
    <name>A0AA38U1U5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_255364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1U5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF3">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="11">
        <location>
            <begin position="87"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="281" mass="31686" checksum="7EAD13E94F9DE99E" modified="2024-01-24" version="1" fragment="single">PMFLHTPRNQSSQSYTRRLRLANLIRPWLPIILYAMTSFVFLIAIAFYKAELFSALDELSRWLQADTTYGQAVLFFLIFLTTFPPIPLYSTLIILSGYTFGPWTGAVISYFAALSGALVVFLLSRTLLRESISRWLSSTCTLKRVVRAIEKRPKLLFLIRLAPYPYNVMNCLLAASPTLTLRTYTLCTALSLFKVIIHSSLGASIHSFKDYHMVTEGDNPSETEESHADTMARMWTIFGIALCVAIFVYLSYVARKAVDEELEDGDDEESVAFLSPEGNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7H4</accession>
    <name>A0AA38U7H4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_340457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7H4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="175"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="478" mass="53154" checksum="71C636C443E98B94" modified="2024-01-24" version="1">MSPAQDIIMQPSQSIETQKIRWPVHVEVRLKSRSTSRFDSIRTHVHAWITAFDRINLSSSLDGWEDVPELAASVERIVTSESSCPFQSLPVDEMALQIHVYQPCDSDAFEEFSNSNSEDDDETMAATVRELPNRSWEGLWNSLIYEDNIKMKLLDYIHATLVLSDAEVDFNLVSWNRVVLLHGPPGTGKTSLCRALAQKLSIRLSQRYSHARLLEINSHSLFSKWFSESGKLVQRLFSSISELADEEDAFLVVLIDEVESLTAARASAMAGTEPSDGLRVVNALLTQLDKLKHRKNVLVMSTSNLVKAIDSAFVDRADIVQYIDLPPREAVYEILRTCLCEIINRGIVSSIDVPSLQQALMYERTAPSQTSTIISDGSDAHEKSEILGLRLLALATQCRAQKMSGRALRRLPVLALARYISAGSIISPDPPEMKGRYNVNGSSTRASIGTSSSAEVDTWLSGMESVVTDQGRQRECLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K841</accession>
    <name>A0AA38K841_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_437434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793584">
        <property type="protein sequence ID" value="KAJ3781239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K841"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="4">
        <location>
            <begin position="50"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="329" mass="37098" checksum="7D5D95AA69A4AA24" modified="2024-01-24" version="1">MEPCRSDMLTSLAKKCVFHSGWSHTGMLYSPMLQRFENHGRRAWLNEHRQNIVNKNLCSEADQTYAILGKLPWNSPQFGFDDCKPIHTLWRTLGTSWMNTSVIDAALEVINVKADVRFDLTSQTLIGHSDIITKLMFFFGGDIEKPKEYTSCDWLNNIRREVFQRGKRLLTIAHLGKLPAWKGKTKGADHWVPVGVDGSDLTFLYGDSMCGQKTPVMPPALFKAFTTWKSYHTSAEFTMAPIEITQQTDNTSCGPCALNAINCLAFPELDELAKPEDIACVRLRTLYNIISHVIDMADNTGISTASKASELTNWDDEDDESQESFKSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K897</accession>
    <name>A0AA38K897_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_366393</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793546">
        <property type="protein sequence ID" value="KAJ3781554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K897"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1082"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1123"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="583"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="833"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1208" mass="130408" checksum="819A038BF34BF766" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8W5</accession>
    <name>A0AA38K8W5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_362206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793442">
        <property type="protein sequence ID" value="KAJ3782994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8W5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="228"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="391"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="842"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="924" mass="102950" checksum="2B7FDDA3F7FD014E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAN5</accession>
    <name>A0AA38KAN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_386529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="468"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="986"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="912"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1189"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1295" mass="143624" checksum="2C16E2EF5641DBE0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB57</accession>
    <name>A0AA38KB57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="446" mass="50001" checksum="1C6D28D61CF92FAC" modified="2024-01-24" version="1">MDYGETPHDFANLHPNFLPSKIHSPAMVSAPVEQSYERTPTEWIRNEEALKVRKFYTQDFTPDTPKRSSEKDANKKAEKEAKRYSLRQKRDSVQEWLKSVEIAQGPSISGPRSSSHDRLGVTVTSRAFLSDGSEPLEKDGQREKRERRERNEGDRKERAKASFNDQSSNPNDHPKTSLLSQKPNSNTTATSHVGSTITPGDDSKLLLSFSNSLVQKSTDTSANAHIGSEKARNSAHHAFIRNSEETLHRFQGYGCFARGPDDSLKEEEEEQITSGESQIAVMDSSVPLLHHSQTNEQGALLQLPQKLDSRYVPDNHDAIVVTESSLPPLPQSSGLSILFEKLDVMRQREEEKHIRSLAEEMRFAEQKQAEDEYYADEGVIVLAQDGQIYSDEDEDIDVVDVREVTEEEAFEVVHVDEGGSVVTEEFQKTDYDCDGDGSVSSSVCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBI0</accession>
    <name>A0AA38KBI0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_418401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793863">
        <property type="protein sequence ID" value="KAJ3780193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBI0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="580" mass="65288" checksum="7526CEF9E9BD342C" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBS0</accession>
    <name>A0AA38KBS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_321589</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="MU793702">
        <property type="protein sequence ID" value="KAJ3780553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBS0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3780553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="339" mass="36518" checksum="2D8726BCE131C6C9" modified="2024-01-24" version="1">MSYAHSVVNTSVQLVDAYPLAASLLLGLGAITIAKFCYRALSVFLQIFVLPGQSLKRYGAKKGAWAIVTGASDGIGKEFAFQLAKAGFNVYLVARNIELLDTTASEIASKYSVATKTTSIDFAKADNAAYEALSAEFQGLEIGVLVNNVGKSHAMPVYLVDTPKEEMTDIVAINVNATLRVTHSVLPGMIQRKRGLILNIGSFAGAIPSPMLATYSGTKAFLSTFTSALAEEVEQHGITVEHINTYFVVSKLSKIRKSSALIPRPGPYVRSVLSKIGLSCGAAYSGRPNTSTPYWSHALLDYAATVLNAPSLLIKYTHGLHKNIQRRALKKMEREAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCD0</accession>
    <name>A0AA38KCD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_106047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793544">
        <property type="protein sequence ID" value="KAJ3781573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCD0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30277" checksum="B3F559D696DE0C87" modified="2024-01-24" version="1">MKLANAFGLWTELNFALQAALIPTLKDVWQKPTIISHLSRTFMAHVWIAFASQVDANARTVKRELFLPNATGVVLDIGAGLGHGIQYLDGSKVTKYVAVEPNVRMHPELRRAAAAAGYLESDGTLIILGCGAEEVATILESLDSTIPAVDTITSVMSMCSIPSAEEALHGLVRRILKPGGQLLFYEHVLSPRKDVAWWQRLWAPLWQIFYDGCRLDCPTDIWIDEITDVDEHGEKMSVWSERKLWGVPGETEETVFHHVLGKFVKRGGKMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCU6</accession>
    <name>A0AA38KCU6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_275426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793472">
        <property type="protein sequence ID" value="KAJ3782503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCU6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="142" mass="16367" checksum="58A87DCDDD625DA2" modified="2024-01-24" version="1" fragment="single">ELRKSTRSPSLVKLQSLLELTLNTEEREDTMFREDVKVVMAGSGLYDWLMKIISTGGIGSERVGEGEIGNLNEEKMDHKDDKRPLLASDTLALDYHVKFPLSLVISPKTILRYQLIFRFLLHLKHVEQSLGAMWIEQKTRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE35</accession>
    <name>A0AA38KE35_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-reducing end beta-L-arabinofuranosidase-like GH127 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_409635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793507">
        <property type="protein sequence ID" value="KAJ3782006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE35"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041296285" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="2">
        <location>
            <begin position="427"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="649" mass="71931" checksum="CD5AE975630C55BC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE42</accession>
    <name>A0AA38KE42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_364768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793503">
        <property type="protein sequence ID" value="KAJ3782051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="185"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="313" mass="33642" checksum="0CE8FDC1432E08D6" modified="2024-01-24" version="1">MAPAATEAPMPHQQPTGTSQPPSATPANLPIDLSNVQFPQLDRNQIMQLLTQIPGVFSKPSGEGAITEDAAKTLSNLSQQAAFVNASNAAAQHAAAAAAAGALPHGISQPAPFPGMAEPGPSSHPRGPPNLGMAGIQSASQQSKDEEDGDTAEQSPEPSAIPSASGGRRGTRGGAAMGSEEWSRQRKDNHKEVERRRRGNINEGINELGRIVPNGSGEKSKGAILSRAVQYIHHLKENEARNIEKWTLEKLLMDQAMGDLQAQLEETRRLWEEERGLRQRAESELELLRGAKTGTKRANEDENEDETKRQRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE48</accession>
    <name>A0AA38KE48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">6-methylsalicylic acid synthase</fullName>
            <ecNumber evidence="8">2.3.1.165</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_390121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.165" evidence="8"/>
    <dbReference type="EMBL" id="MU793501">
        <property type="protein sequence ID" value="KAJ3782081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050641">
        <property type="term" value="F:6-methylsalicylic acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054514">
        <property type="entry name" value="RhiE-like_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22336">
        <property type="entry name" value="RhiE-like_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="23"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="931"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1713"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="931"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1062"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="963"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3782081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1793" mass="193127" checksum="9A430B3196C1CB65" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEW9</accession>
    <name>A0AA38KEW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_389218</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="MU793427">
        <property type="protein sequence ID" value="KAJ3783281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="58"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="765"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3783281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1021" mass="115225" checksum="175689D5407C3A37" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF37</accession>
    <name>A0AA38KF37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_273370</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="MU793415">
        <property type="protein sequence ID" value="KAJ3783536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF37"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3783536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="557" mass="60881" checksum="9D0D22DA68819367" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH07</accession>
    <name>A0AA38KH07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_408139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041350521" evidence="2">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="171" mass="17900" checksum="4FC036F5A29FA52A" modified="2024-01-24" version="1">MRFSGYLILGLVSAIYAVPLCVDEDNVGGGSGGMACLSMRGLPVGGPLDQKLVRRKGDESEQPLLSKTPSQASLNSGGSANYDEEDKHDQAGAPAAAKRPMSLGFGESSSIHGGGDSDEDDSTPLINKPQDSTSKTGKPGFLSKWAQKAGIRKFTGSSLLRKEVKSTSQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH72</accession>
    <name>A0AA38KH72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_386172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3786986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH72"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041466599" evidence="1">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="373" mass="42517" checksum="DF6C2237E1BDD5A9" modified="2024-01-24" version="1">MLFSISYVLLGLIAVTHAIPIDTDPSHPAHAVSLLDAQHPQPQPRQTPKDEIHLAFCYPDDTGRPGTTPKIKKELKLIVKKYRQHMNISKPFELSFENRYSGNIDDNFHEFVFWGKGDGWDCETDESPCGVLYKTVPIWKQSDPECRMASVYTSPEEDRVFDVTSIPNATSIPVLPLSEKNTPRSPSVTRPMRKEQIFGCRVSPGGNLDSNTPSALAWLNKRPPSISYVLLGFVAAVYAIPVDTAVTYPDRQTHPTSSWIRRQAKDKIHVRFLNRSHTGTGCPVPQIKEEMSLILQKFRQSLNVNKPFEFSFQNRYDEEIDDDEHDFEFWGEGVERDRLDPETMLATISAEKGMKHLLVVNYDIRHNVKDKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI64</accession>
    <name>A0AA38KI64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">21S rRNA pseudouridine(2819) synthase</fullName>
            <ecNumber evidence="7">5.4.99.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pseudouridine synthase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pseudouridylate synthase PUS5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Uracil hydrolyase PUS5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_384462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA</text>
            <dbReference type="Rhea" id="RHEA:42556"/>
            <dbReference type="Rhea" id="RHEA-COMP:10113"/>
            <dbReference type="Rhea" id="RHEA-COMP:10114"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.43" evidence="7"/>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI64"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160143">
        <property type="term" value="F:21S rRNA pseudouridine(2819) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF81">
        <property type="entry name" value="21S RRNA PSEUDOURIDINE(2819) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="12">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="285" mass="31906" checksum="E4900058CE911ED9" modified="2024-01-24" version="1">MTFRIIFRNSFALDFAQVLYIDRAFVVVNKPPKFVTQYPRDGQTEAVAELVGQVPSAPNSTKLFPVHRLDKGTTGCLVFARSPDYAQTFSRQLKQRTVNKIYHALVNTSSSPILSAKTVSGNIRIGMSLKDGRPYISQSSSARETWTDWQVLGSSSQTDIALLKLHLHTGMKHQLRVHMSNVMQAPIVGDLQHTSAQASSSTLPPILNDRLFLHASEISFHRFKRTGKQKRLNLTIRTPLPLDFAELCYRTGIEVPSYLKEGGLFVNGQPMTNVPDLDGFWVYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKS4</accession>
    <name>A0AA38KKS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_246656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793994">
        <property type="protein sequence ID" value="KAJ3780000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="118" mass="13429" checksum="F2C2FB2E439E44ED" modified="2024-01-24" version="1" fragment="single">FGDPLAEHLEYVLTQQTPFPGEPTDKEGVRSIERFLAYRISDYSHLLIDLVYEDRELQIPTQLLVNPDFEPGPWFARQIGDSSAVSKTTSRPMGDTRATRISQILNNSECYRGDNLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKU3</accession>
    <name>A0AA38KKU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_369970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793924">
        <property type="protein sequence ID" value="KAJ3780090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKU3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="559"/>
            <end position="560"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="650" mass="72092" checksum="EEB4BED2D07F2E6C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLW3</accession>
    <name>A0AA38KLW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_364436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793493">
        <property type="protein sequence ID" value="KAJ3782189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLW3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="220" mass="25619" checksum="8769B57FB54F61B2" modified="2024-01-24" version="1">MYKKADLLSTSPYLLCSFEMCTFAADDISTPWPLMVELWEAFQSHQRTAVVLDHFDHELNVVLVGVQTEDGQHRNVQLEVMLLAGSDLIRTLPFFPRCCYPNVYPSARPCSWTLWLFHYRAYCFFRMMFLATRSIDRNFEYPRSLNELLRRGLSVRYLLPSSVVDYIEENNLYLDEAAAAEKQKGKRAATEGVMRISYSYASLSRVERNLQKGFVNHCQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM17</accession>
    <name>A0AA38KM17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_389838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793474">
        <property type="protein sequence ID" value="KAJ3782474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM17"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38062" checksum="2002B8ED456F49A9" modified="2024-01-24" version="1">MFYTTTIPYLFALWTIGFTILVGAAPLAVRASMATGLQSSEDPQGPILTNNEGGQVRLSAPPLMTTPLSPPPPPPSPPSSNASRPLSFVLPKWVTAPYPRSLKAVDMEVFNTILQGITLAKKHSAMGNNNAGVYSVASFDPSFAQLFPPSISAQNIDPSRLLVKVLKHIDDDMVAEVKALKTVGQFVASGLLKLPTARSNELGKMKRGIRDGKVRRDAVNYSLSDDDSFELKPVIVMLKMPGKPLTHTPEFISEKNLETKRQMMSDTLTMMCDRVGKLALEHRFVHRDNIIGNILVINEGSKIVDVNIIDWGGKYLSSIKDDVTWDDLMGWCHNRWAVYVWEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMG2</accession>
    <name>A0AA38KMG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_276119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793495">
        <property type="protein sequence ID" value="KAJ3782160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="154" mass="18044" checksum="19A4D2ECF93E3238" modified="2024-01-24" version="1">MPRIPLIIAQYTIEGHRRGPDYKHWAIVALQSQNTADTFQLLGNSDTFTYTPRQVTQFSQSRRFRGGYKVGTIDLSQVDWLYETLRQVPIHKYDESWDCQSWVLDALLYLRELTEGVVTENIGRAHIQAQMNDEYNRWQYGGQTIEERLFPSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMN9</accession>
    <name>A0AA38KMN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_296374</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000647">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="79"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="619"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="868" mass="97001" checksum="A3D778006804010D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNT9</accession>
    <name>A0AA38KNT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_360114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793408">
        <property type="protein sequence ID" value="KAJ3783675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNT9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="208" mass="23239" checksum="78180E5522B5712C" modified="2024-01-24" version="1">MDNAYQASQSSSARRPDMKRKLVVVGDGGCGKTCLLIVYAENRFPEAYIPTVFENYVTQVQFEGKEIELALWDTAGQEEYDRLRPLSYPESDVILIVFSIDFPTSLANVQDKWYPEVAHFCEGTPLILVGTKTDLRSDDQTKRMLGAQGQTPISPQQGAAIAKEIGAKYIECSAKTGRGVHDVFNLALKESMKGRWGKIVKKRRCIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP11</accession>
    <name>A0AA38KP11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_359513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29557" checksum="6940121CAD4928BE" modified="2024-01-24" version="1">MTLPNSMSISCIQYNWASNSLGQNPCDVAERLNSVCTTSNGSYFVELTSDEDYTLSEEDQNPCLCTSVVYNLVSMCRLCQTDDGKVYSTWSQWSTNCSSLNTGFPLGLPGDTAVPDWAYQDISESDAFNETLAAEVATTDHSESSSSALSSSTSAVSPTSSSVRPPKGPNGDTAVIVGSLLGGLIGLALLVVAILFFIRRRRRSRMAPSTVYLEASHSREDTTSRGRYTQVDALKTERAVPDLPYNIVSDDHSSFSFDPYDPSLTSSEKDPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPJ9</accession>
    <name>A0AA38KPJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Redoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_294202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793375">
        <property type="protein sequence ID" value="KAJ3784470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPJ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="19036" checksum="1CA14426B7B98AD3" modified="2024-01-24" version="1">MTSLIATSAEAAHSLAVSLLSKAQIQPGATIPEHSVKESAPDVLVPLKFSGRNVIVGVPGAFSGTCTVQIPGYIQNYDRFKAKGVNEVYVVAVNDAFTMKAWKEKLAPTGTGVRFMADDKGTFTSALGLMFDATPKFGAPRSKRYVIIADGDKAESLFIEEDPSKVTITDAETVLSHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPT3</accession>
    <name>A0AA38KPT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DnaJ-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_354309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPT3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48175" checksum="EF243633BA52B013" modified="2024-01-24" version="1">MAVETVLYDLLGITPNASEDEIKKAYRKKARDIHPDKNRNDPNAATKFQEMAAAYEILSDPDTRVLYDEGGMEGLQGGRSGGPSMDDIFAQFFTGGSGGFSFGFDMGGGPSRFGRQNDSVLPHEVTLEDLYNGKTVKMNMEKQVLCSSCKGSGAKGHAKPKQCSTCEGSGRAYIKTQLPGGQMAVSPQRCEACNGKGENLREKDRCKKCKGSGTVKEKTRQEIFIEKGMADQQRIVLAGAGDEEPGVSAGDVVFVLKVLPHDSFERNGNDLLVKVKITLSEALLGFSRILLTHLDGRGIKVTSPPGKIFQPDSTIVIRGEGMPIYKRPDTKGDLFVLFEIEMPSEDWLRSVDQQALANLLPPKKPEIQPEPKIVDEANFEEIDVRSQSFPASQDFFDHGFANQRDAINDEDWEDEDDDEGDTFDDYAGGGPAEPECRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQD4</accession>
    <name>A0AA38KQD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_173719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40884" checksum="999E5D3F56CFB651" modified="2024-01-24" version="1" fragment="single">ELCKHPLSTLKLVGALFLSNVGNTRVSLLRSPLHHTAVNTFFSKRFHTRGGPILENVFTQLKKLTLDRVGWWTLNNIARDSLYNGFRSVTELHLRHVSFSDIQELQVLICSFPLLERLHLTLQQPSASYSVVKNPTGLQLPKRLYAIDITTVDEATFQGLSVITPCPSLRQFCWRSNVFYELEDECRNVGEFLEATGSSLVELSLIFNVDMLSNDIRIRQPTNKVAIQQFMRFHDCVDLTKNPSLQRVTLDIRPDPYLVLFLQYAIRNEQALSVQSLYIPFLENVIFSLNPRILSNEGLTQNDLDIALQQPALANLRRLEFGVQGFFPRQSVTEKIAQVLSGLMERPMLLLPNQDDCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQG0</accession>
    <name>A0AA38KQG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_274027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793432">
        <property type="protein sequence ID" value="KAJ3783186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQG0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="170" mass="19991" checksum="01B3834439191FD2" modified="2024-01-24" version="1" fragment="single">KWFKDAFDFLNIDLGTSFATLVACWLKFEGLYGWKPTRNVLSSVHRPKEVSKWIRYGRYAKINITIAPSQIEGFAERMWLWWLHLQPKWRELGQDLWPLPVEQFGDDWRLLDVHGINGWLSLLASLRWWGESLAKLGSSEPNSRSNDWLALIADMCKMLEGLTMYKQKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQP9</accession>
    <name>A0AA38KQP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_52031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793417">
        <property type="protein sequence ID" value="KAJ3783486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQP9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37025" checksum="139A69F7B92FDE83" modified="2024-01-24" version="1">MPLGRGIGSDSGVPVRIRSQAGILRPDVAMFFGFRNGFLAMDAQSQHLFSLPIPPSTLAALTKAGYETLDDLPQSDSANQLIDVLNIPFGASQTLYSSSQRPNGGGPGILPSTQTAASLIGSISKQKSRRFTTHCPPLDALLDGGLPEGGILELSGPPGSSKERILLNMVRSFVEAGRSILLVDCQNMCDPCILDELMTDNSSARRLVSYLKIGSLTELMMFVNNLSLCNDSFDLLAISCISYPFQNARLTKSARNYILEKIKQALTKVNISQNVTIVVTSQLVTKLVNIDGTTGNFDSVGAKGVMVPALGHVYLPSAKAFRVLVALNGPTLDTGSFRLLAPLKPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR79</accession>
    <name>A0AA38KR79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBF/Mak21 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_290340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="627"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="898"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="942"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1103" mass="121314" checksum="D04546FDF2226EDF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR88</accession>
    <name>A0AA38KR88_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_415903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR88"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="34730" checksum="FA026B387E9F62B3" modified="2024-01-24" version="1">MGQLSLEKTFIIAPYIEGIVYGFFVAIFAATMYIHFSKVINGPQQLGRHSNVMIGISSLMFFIATLHMAVNAYRLIAGYVDHASVPGGAVAYMGDLRTWHYILKDALYATQENLGSAAAIYRCWVLWNHNWKIIVFPSVLLIVNIVAGYMVCGLYTTVSSTINVFNPRLTTWIKIFFPLTVALNIITTSLMSYRIWYTHSQATLYASDNGDSQVMSVMRMLVESAALQLVVEIVLLALYSSDINAQYIILESIAPIVGITFNALTIRIKLRSMSAARNDGDTQTIGRLPMRRLQVNVAIEQTEDSDSIYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRC7</accession>
    <name>A0AA38KRC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_401806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793381">
        <property type="protein sequence ID" value="KAJ3784326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="586" mass="67417" checksum="6D06928970662FF5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS29</accession>
    <name>A0AA38KS29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_333268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793348">
        <property type="protein sequence ID" value="KAJ3785241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF152">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="499" mass="56887" checksum="D11562CCE6CC2C1E" modified="2024-01-24" version="1">MYLLLASLALSYAIVLAFYRLFFHPLRKYPGPILAALTEGYELYYNIIVGGGLVNEIEKLHKIYGPVVRVGPNTLHFNYPQAYHDIYTYGTTLVKDPGFYHGTAAHVRQSAFAFCDPQHAKIRRGLMSPLFSRRAVLELEYTIQQKIDKLLAVFWEHYNSPNSSVEMSSAYRSLTTDIITSYCFAECPNTLDLPDFSHPIIQYVEETFQDYWLQRHFPILTSIINNGPQKIVLWLLPKFKGYAGLKKGLERQIDKILDNPDILSSAEHETVYRHLLEPKGQERPSRTALLHEAIVFTAAGSDTVGNASYVGTFYALKYDSIRRRLSEELSKAWPEKDTPLGYAALEKLPYLTAFIKETLRFSVGVIHPLPRIVGPTTPEIGGLKLPAGTIVEMSALFMHMNPDVFPDPYVFNPDRWLAGETNEMMHDFVPFSKGSRICVGLNLAWSELYLIFGNLFRKVDLKLAIDDDTIDDFSPEQRMDYFVVQWRKGYRVSVGKTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSF9</accession>
    <name>A0AA38KSF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_287415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27332" checksum="8F75331E5707E35A" modified="2024-01-24" version="1">MFSPFDLPEDIFLLITDELPSPADFALCQCLVSHIKEKQNSSLRVVLSVSESLTRWQSILAKSNVNLSQQIAAKTFHFIDITSMALVQTDTDKVHGNPFHGLFEQISSILEEGNRDLSPGALVVLDDISSLEWIGFSTSDLLRLCRALRALCLKNQATLIIRHHIVTPGELDPLFRHLHSLCTYHLDIQPLNSGRSGDVSGQIALHSGPNAFPQSAVKTRQRSAALQYRLTDGTAIFFERGSSRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTN6</accession>
    <name>A0AA38KTN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_349018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF152">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="500" mass="57115" checksum="A4D58BC3E9980524" modified="2024-01-24" version="1">MYSFHLLTLFFLYVGSLALYRLFFHPLCKYPGPILAALTDWYELYYNIIKGGGLVTEIDRLHKLHGPVIRIGPNTLHFNDRRAYHEIYTYGSTLVKDPGFYYGFMAHCPKGLVSTCDPEDAKKRRSLLGPMFSRRAVLALESTIQNKIDQFIALIEENYSSKSSSIQMALAYRSLTTDVITEYCFAESANTLTPGFNHPIQRTVQDFLKRIWIQRHFPFINSATFKAPRTLVQWLFPAFKSFVDMKAAYGHQIDGLMDNPSSLSDADHETIYHHLLSQKDQAIPSREILVDEAFTLVGAGSDTVGNVCTVGTFHALKNQIIGQKIIKELCEAWPDKDRPMDCTALENLPYLTAFIKEALRFSVGVVHPLPRIVGSTSTSIAGYEIPPGTVVKMSILFLHMNRDVFSDPYTFNPDRWLADDTSDMTLDLAPFSKGPRICVGLNLAWCELYLIFGNIFRKLNMKLQDEEVNQRIDFRQGFKSDHLVPYWHWEAYRLSIERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTZ8</accession>
    <name>A0AA38KTZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_347881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000157">
        <property type="entry name" value="Alpha-1,3-glucan synthase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000162">
        <property type="entry name" value="Cell wall alpha-1,3-glucan synthase mok12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041247508" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1916"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1950"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1974"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2006"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2077"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2158"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2230"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2257"/>
            <end position="2276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2311"/>
            <end position="2330"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="68"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1650"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1688"/>
            <end position="1702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2338" mass="262017" checksum="3C59AC61B1AEAA89" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV23</accession>
    <name>A0AA38KV23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_361442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793429">
        <property type="protein sequence ID" value="KAJ3783237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="226"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="48234" checksum="24986679F08B871E" modified="2024-01-24" version="1">MQTAANKFQEYLGTEPADVHAEYIHVEGGASMKALAWFGTNDVRMVAAPIPDITEPDDVILQVTGTTICGSDLHLYHGEIMALQKGDILGHEFMGKVFKVGPNVKNLKAGQRVVSSFQISCGKCEYCKENLSSFCDRTNTSSLQNYMYGQRDAGFFGYSHFTGGFPGGQAEYVRVPIGEVNLLPIPDNVSDEKALYLSDVLPTSYHTVVDTGVKPGDVVGIWGLGPIGQCAARWAILKGASRVIGIDRIPSRLQFAESKTGVETIDFSQFSDVTKRIYELCPRGLDVALDCGTFHEPKTLTHKIQKTLLLETDVPETINEMIVSVRKMGRCGLIAAYAGFANAVNVGALMEKGVRLIGNGQAPVRKYWEEILNEYIIPGKFDPTFMITHRVPIDDLAKLYPAFDKRVDGVEKVFVETRFSSAPSSGCPRTSRVDDWKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW74</accession>
    <name>A0AA38KW74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW74"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041265434" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="121" mass="13830" checksum="8EDBD58B2CBE16DE" modified="2024-01-24" version="1" fragment="single">MQIHLIYVGFILGLFATVQAAPFGRWPGFEKKAQGHREKFYVTFDWRPFYPSVSVPREVALRLASNIHEQDKAFRIDDPAHQIEYLPNMWPPGLSPRAAIDFSWGTTPNSVYSSGHLTELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWA1</accession>
    <name>A0AA38KWA1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_369940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793910">
        <property type="protein sequence ID" value="KAJ3780113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWA1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041459117" evidence="1">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="156" mass="17406" checksum="A2482991C9A9D52D" modified="2024-01-24" version="1">MVTMRVSPGCLLIQIVLGLFAIAFAMPPPPIGTSSDLMRRDPIEFHYFITFTIPLDETPISPQPANVNTEAMKLVRGVVKKHTGKAHVKFTTPTYILNRLPYYITFHATMIQRVDGEDHADYYYQGVVSSITGAGILEEGMEDGHAEQILNQFQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX40</accession>
    <name>A0AA38KX40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_110418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793562">
        <property type="protein sequence ID" value="KAJ3781403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX40"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="965" mass="105061" checksum="D839CCE5572E6A19" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXE9</accession>
    <name>A0AA38KXE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_393921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="321" mass="36125" checksum="33F3FD4E58429CFD" modified="2024-01-24" version="1">MSGDLYGILHISREASPEEIRKAYKKRALQTHPDRLPANYTPAEKTAAEDKFRKVNNAYEILKDPEKRQSYDQYGAWPPPAVPPTSPHNYSSRYRPYTNDFSRPRPDPFTLFTDFHFTDPFELFDSFFHDSLGVHSHDRRDNRFPRRHTTYEDSNNFAFPRARDMHSGVDALMAHIDDMHRNMLSTSTANPRMGMSTGMGSMGVGFPPMISHFPTFPRLDTRSGSGNGRWAAESTVSQTVNGVTQTIQKRRDWEGNVHVTRTYPGGRKVVTINGVEQHDQGQAYLPSPPPPPAPNAPSHGNNYLPSPPPPYSSNPNSGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYU4</accession>
    <name>A0AA38KYU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_402278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793387">
        <property type="protein sequence ID" value="KAJ3784178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYU4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="391"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="510" mass="56405" checksum="21D157FD747C9D8F" modified="2024-01-24" version="1">MAPIYNNTFSGKDALAKFYDPDCNPMLPLVEIPTHPFEKDGVHIYAKMLTFLPAANVKSLPALNMLQKAKEAGKIDTSTNIVEYSSGSTIMSLAILSRVMGLNGATAYVSNKTTKSKLNLLRFFGLETKLFGGPGQPSPHDSNGGIFRASRDGQTGNNFNPSQYQNADNYRAHQRWTGPQIIKQLPNISVFATGMGTTGTMTGTGSYLKDFNPKIVNVGVCTAPGDLVHGPRNLSLVGDIPFPWQKAVDVLEDASAFESFAASLDLCRNGLLGGPSSGLAQVGLFKFLERTRLEGGLDRLRADDGSINCVFTCCDLPYQYVDEYFQILGESYFPPIQEEALLHVDRYPYQPEWELAAEIVLSKILVHMSNEEMCDKKNSWSGREFSSRPAPCENLVILDIRAEIDYNKRHFPAAISFDIGSDAKSPNPFLDTPTMIKQWRSLNQQLSHEHPIFDEKVKGNTMVVFCYDGNTSRIATSILRHRGVEAYSCAGGIGACWKLLDRIDGRERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L086</accession>
    <name>A0AA38L086_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_308938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L086"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="726" mass="80576" checksum="F6B16EB7ACA60E76" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0L1</accession>
    <name>A0AA38L0L1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_307072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0L1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="617" mass="69015" checksum="7F55803F3BDEA4BD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0N4</accession>
    <name>A0AA38L0N4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_372965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0N4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="3">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="2">
        <location>
            <begin position="123"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="304" mass="32926" checksum="7F3A64BC64FD0CA9" modified="2024-01-24" version="1">MFSRLSIVPFPLAARRHLSTSPVQWAGHNKWSKIKQKVFLVRHLTSNSPDTTKKGANDASKSAAFQRATQDILVAARSGGVDPDKNAALAAVLKRLKAQDVPNHNIEKALAKAVKVKSSGEISTYEAIACNSVGIMIECATDNPNRTAQTLREILNSRNARMAPVGFMFVRGGRIVIGVQNNPDADALLDAVTELALSHGAEGYDTVPPLTKNDSQLQMNFCCQPPALSKLTNELKKRSGVYILESQLVHYPVTKTELPDEDTEILEDLVHALEAHDDVIRVTTSATQIIPGSITATSNIDGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2N1</accession>
    <name>A0AA38L2N1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_84640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793492">
        <property type="protein sequence ID" value="KAJ3782197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2N1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="88"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="563" mass="61610" checksum="86EF8AD59E63C6CE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3C6</accession>
    <name>A0AA38L3C6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_361151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793423">
        <property type="protein sequence ID" value="KAJ3783367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3C6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041427381" evidence="2">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="143" mass="14707" checksum="AC8B439CD5AD4AF8" modified="2024-01-24" version="1">MFSPIMKLALALALISGLALVAIPSNASPINSTLLARANTGDGTFYAPGLGACGVTNSATDLIAAMAHATFDSYPGATGNPNTNPICNKKVTANYQGKSVTVTITDRCAGCAGEFDLDFSPAAFDKLADESVGRIHGMTWDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4A2</accession>
    <name>A0AA38L4A2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_292986</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4A2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3785062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="533" mass="60900" checksum="D31933AC0CDDC4FF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L586</accession>
    <name>A0AA38L586_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_350480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L586"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="47"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="473" mass="51245" checksum="CB254B825FCFE138" modified="2024-01-24" version="1">MVNTYGATTSSLAQAGDEEDSNEHTAFLGDNRDVVTAVKDDKPDGHASMISSISNLANTIIGSGMLTFPLALASAGILPGMLTCVLSGGIAAFGLYLLSLCAAKTPHRRSSFFAVAQMTFPKAAVFFDAAIATKCFGVSISYLIIIKGLTPNVVSSLYHDLSDAEPPAWMLNGRNWLSIFMIVLIPLAFLRRLNSLRHTSYVALFSVVYLLIIVVKCYFWPLDDMPPAGKIRLVHFTSNFVSTFPVQVFAFTCAQNLFPIYNEVKSNTQPRMNIIIGSAIGSATLTYEVIAVFGYLTFGTNVGANIIAMYPPNSLFVAIGQVAIVILVLFSYPLQVHPCRNCLDKVFHAGKSVKQADNEETEVEMDDHSIVDMSHTKHTILTLAIIASTFTIAYIVDDLKIVLSFVGSTGSTTISFILPGLLYWKLSRGDHGSKILNRAALALAAYGVCIFVFCLGFNIYQLVYPPASGSPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L620</accession>
    <name>A0AA38L620_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_346251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L620"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="486" mass="54040" checksum="5073020FEB3D1D82" modified="2024-01-24" version="1">MSDSIHVEEKAEIDETRASLDEGDPDAIFGGLEARLVLERKLLWKIDLRILGVLVPIYILNYVDRNNAGAARLRGFESDLHLKGQEFATLLSILYVGYIIMQIPSNMFLNYIGRPSLYLPGCMAIWGMISCLTGITNNFVGALLTRFFLGFVEAAFFPGALFLLSKWYKREEIGRRTAILYCGNLISNAFGSLMASGILSGMQGTLGHAAWRWLFYIEGSLTVFVAICAMFILPDFPTTTRWLTPLERKLAVQRMKEDAGVGDQGETEVGGQASGLILALSDWRVWWMSLAMTAQVVSLSFNAYFPTLSATMGFNNTVTLLLCAPPFAFASLAAFFLSRHSDQTKERFWHVAASFGLGIIGFIIAIATMNTAARYVSLFLMAQSYAGFVVVYTWISNSFPRPPSKRAVALALMNAFSQLGNVAGSYVFPTMWGPTYRNSYAICIACAGLGIIMCWVFKLSLVRLNEKIEKEEKEKGIREKGFRYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L671</accession>
    <name>A0AA38L671_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_345024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L671"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="73" mass="8021" checksum="03DAECBF205C6D96" modified="2024-01-24" version="1">MPQRQKDAFILIVVCTGALGFSAFCSSRSCYCSSGIVSWKNDLGTCTSATFVATYSMNELMKDEGRQLLIPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L686</accession>
    <name>A0AA38L686_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_310213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L686"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="557"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="722"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="769" mass="84523" checksum="8400FB5F4D5CABC1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6K2</accession>
    <name>A0AA38L6K2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_348135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6K2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="15"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="200" mass="22272" checksum="5B6B16E471B6F25F" modified="2024-01-24" version="1">MTFIAEQERTEGFTHVLLITTGSVASVKAPLIVEELLKHARVKVEVVATQPSLTFFNVDHVIKAGSRVWVDQDEWKKDYKIGDPILHIELRRWADIVLVAPCSANTLSKISHGICDNLATSLLRALSPTTPTYVFPAMNTLMYEHPLTSEHLRIVREVVRYSVVGPIGKGLACGDVGLGAMTEWQDIVQIVVDRFQLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB20</accession>
    <name>A0AA38NB20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794058">
        <property type="protein sequence ID" value="KAJ3779926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="602" mass="66260" checksum="7B038B88E8292872" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB88</accession>
    <name>A0AA38NB88_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_380745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793772">
        <property type="protein sequence ID" value="KAJ3780361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB88"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="126" mass="14278" checksum="A765CF291F0F2113" modified="2024-01-24" version="1">MPFELKPGFPTPRKWWNIWFIPVTNVSSRNGIQLIQTLCILDVKAVQPERITIEVPEAPDEVPSVGTVAVTQGCTQKGLTVLGSMMELQRSFRQRSLHAIWVSLRSVKKKEVPERRTEPIGRSGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCV5</accession>
    <name>A0AA38NCV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_292722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793350">
        <property type="protein sequence ID" value="KAJ3785191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCV5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="170"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="437" mass="49916" checksum="8E264006847ACD3C" modified="2024-01-24" version="1">MQIVIGLLIASISVYLFTVQALRWRRYTAVHRKFGHKHQSGLLTPEDAQEILRVSSLYDMPTLMNYALAFALFKTYAIPSISKILSNTKELKSAQSISKRYADTEILISTWVFCPISGKSSAVVQPSNTSRQSFGNTADTQKAGATAERGEVDDPRAMIALARVNWLHSKYSITNDDYLYTLALFAFEPPKWARLYGWRALSPMEEEAFYIFWVEIGQRMGIRDIPETIKEFRTWVVEYEAKTMVPAQTNHDVATYTTEELLHVVPESFGLKKFFRRLTVCALEENVRIAMIQPKQPTYLHFILRTVLYSVAFVQRYLCLPRSDSNHGAAIDISLPEDAAIPACPLPSSKLYRMHPKWFQARPWYKPEPRTFSGRIRDWVAFKIGLYDALPGPRLKSEGYRLEEMGPAKYEKSGNEEAIGMAGEFYGCPISVPFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDG9</accession>
    <name>A0AA38NDG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_433326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDG9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="443" mass="47169" checksum="00A47C265DA30B6B" modified="2024-01-24" version="1">MSYYHHGGEYQQDSDLPNEQTEPIPSWETLDPQPQQPQEPPSSSAFVSLTVPTPHALPPQQFDYSPLHTPIDYGMNFAPQERLVRSEGYPSPETEAFQHSPSPTTPTVPGPQRTRPRGAASHGTKGSGIQHQHHPYRRPQSALAGKAKEIAGARYSVVTGGGIQSYPASMSAPLQEAGLSSHQPMGPPPEPSHPSPLPPPTSMWPAPDTTLSSSATAPTVDFENSIRRVREVTKHFFTPRLDSFYDTSNHILKAYLELPGVRREHLFVTLATSAITRHRSVNVWGISLSPAWLSAGAAQAGAAQAGAAQAGDGTTSTSQEPSSLGKTMHMSSVPSMSAGEAAGTARASSAPSPDGGSGGAAGLRPPMVTSEMEMSLGLGLPPQYTLRERRYGEFLRLLPVPPETRARHVQAILEAGVLSLSISFGIPLTEGQVSSVREIITVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH71</accession>
    <name>A0AA38NH71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794191">
        <property type="protein sequence ID" value="KAJ3779807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="118" mass="13960" checksum="2A8997A680B24053" modified="2024-01-24" version="1" fragment="single">RRIPIMIEAHEKTGHKGIWATNSSIHERFWWPRIIDDVKWFIKTCHICQLRQTEKLRIPPVVAQPLTLFAKCYMDVMEMPKSGGFKYIYRSRSLLIICIPRVSKTPSTNWGSNRKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHN9</accession>
    <name>A0AA38NHN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_277580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793561">
        <property type="protein sequence ID" value="KAJ3781412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="266" mass="27849" checksum="D8660A21A1D125DD" modified="2024-01-24" version="1">MTAANFEADALLAHVVSQVQQNVEFLVSQNYLAQSDASAFLSKLNNVGVGAAAAPVMPIPTPTSFARKVPTVMSPPIMAKAIWAYNEDGADPADLSFAAGDMVEIVEETNSDWWTGKLNGRQALFPSTYVQKVAASAPATMPTPIPASGGRTLPPAFNGAKEKPVYKPFGAAHQSANVPPPSGAGMNNVGLQEDAGQEKKKSKYGKYGNTMAHSAAGGVGFGAGQLSSSHTSVRFLISSSQVPLSAVVLFEPSSDRCRRSHITFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHQ4</accession>
    <name>A0AA38NHQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_366468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793549">
        <property type="protein sequence ID" value="KAJ3781532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="102" mass="10791" checksum="08A11040A787E5A6" modified="2024-01-24" version="1">MPLPESTLTRRGPNTNVTCGTEFQWTEDTAQLSPCLVAAAVVGGCGSSDYTVPSLTAGIHYNPPGVNGQPINGCSWWAPFFLFSGHSLIAIVSSTSLYLSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI19</accession>
    <name>A0AA38NI19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_74747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793461">
        <property type="protein sequence ID" value="KAJ3782657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="32488" checksum="4493780A2E7F2853" modified="2024-01-24" version="1">MLMQDLEPLDPSYVQQILSRPPFVYVSGVINVRDLGGHPSSTHPGKLTKPGFVYRSAEVAGITDEGKEQVRRLGIRKIFDLRSDTEISKYNAPLPVIEGVDLLHIPVFQTEDYSPEMMAKRYQLYASGKTEAFMELYSQILDHGGPAFGSILRFIRDHANEACMFHCTAGKDRTGVMAAILLKLAGVDNAVIANDYSLTRIGREPARAKIMERLSKEPLFASNNEAALIMFTCREETMLAFLELLDTKYGGVVEYIKNYVHLSESDIDIIRNNMFVSSDRVAEEDDTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI49</accession>
    <name>A0AA38NI49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_406573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793445">
        <property type="protein sequence ID" value="KAJ3782942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="457"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="697" mass="77376" checksum="6E84571B81BCA525" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIM4</accession>
    <name>A0AA38NIM4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_358898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIM4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="115" mass="12689" checksum="B23821C7BA300B26" modified="2024-01-24" version="1">MSLANPPQKTASGRFLIIATIRSKPGKEETLGELLKLIQKRANSDEEPGTFTYRVTRRIDAEGKHLSDFVIIEEYDGAAGLKAHMAAAPFQNVIKIAKEQDLMDGELSGDFLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJJ8</accession>
    <name>A0AA38NJJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_368269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793627">
        <property type="protein sequence ID" value="KAJ3780934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJJ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="9">
        <location>
            <begin position="86"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="728" mass="82281" checksum="23FFAB4E0716B77B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJN3</accession>
    <name>A0AA38NJN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_379236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793527">
        <property type="protein sequence ID" value="KAJ3781758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="485" mass="53397" checksum="47DAEACA3E9865E8" modified="2024-01-24" version="1">MCPDLEEISSANASIKTQSDVNDTKDVQNVRGGDASDEHENDSDDEELKRLEEQISRHKAQKIFLDFAKKLALCNDIMAFRTNELLSITKRSCSNTSDQTSVENYTAVKRNKVEVGGLRPDWKSKVSSQANVLHSSTPSRNREDNDIEFELGGEFGKEGVEKGTDDGPIGSGNEDDIVQVKLEASDANLILKEECETGKPAKSPKSSHVRVSDLPLILSSDQEVWKSAIHSSLIEWSATCAKQFHINSDPKFRPVVQELWNVHLGSLPHMPLECEYKGGKIKRSEHPSVVAFEYLEENGITMEGRRNVVEGLLHHEAFVYEKPGPTRQTSSGAFRGILLMRTFAFYLTWAFAVPNASKSNTHPMGALSLATTAVLRALDVFKSGSNAMTDTNNGKKKKPASSPDNFNDKWASQQAKFHNSISQLNDDKWALILRASEAHISGIPNAGAGPFLKHVLQVEGIKTNFQGMQEGNVAAAGDDEIMVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJZ4</accession>
    <name>A0AA38NJZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_378759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793488">
        <property type="protein sequence ID" value="KAJ3782253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="217" mass="25391" checksum="41BFA107E05CDFC8" modified="2024-01-24" version="1">MKRDPVTFTWLPGFTSAHPHLRKIRFHDESNFYFRRNLTIPFIVHFDDQVRRERHLDDAFDLAWLVILSRHGSTTQLFEQWHVTGRFYYYAPKFPITPKGWPASFISTPPLRLWTKLLAKVIDQSRKKIPAVMAEAGMLWYTSRIARTISSVEAFSIYEEGYDNYNDWWTTSGWFIVQIAPRTGRTGVTGKLVDAVHLRLLGNAFLSKFIQTSVYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKC1</accession>
    <name>A0AA38NKC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_155667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKC1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="91"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="270"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="422" mass="45799" checksum="F2591F9CC0ED418F" modified="2024-01-24" version="1">MSSTSITESVAIPSSTDSAALSVTTVPFASTDPNEPLWNIDSPDSAPSPIRGSLGASIMGPDNIPIDLENPDLFAPPTSDNGDTGNSKWPFALSHNRLQTGGWARQENIEVMPIATAMASVDMRLEAGAIRELHWHKTSEWAYVLKGTSQITAVDTEGRNFIANVRAGDLWFFPPGIPHSIQATGDDPDGTEFLLIFDDGAFSEDSTFLLTDWLAHVPAEVISKNFQVNNSEAFAHIPDKELYIFPSTVPPDDQQAPVSPQGTIPLSYMFPLSTVNATQLSGGSVKIVDSTTFPISTTIAAAEVTVEPGAMRELHWHPTMDEWSFFIEGTGRVTVFASQSNARTFNYQAGDIGYVPAAMGHYVENTGNTTLRFLEIFNSDRFQDISLNQWLALTPPSLVKAHLNLDDETIAQLSKTKPTVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKR0</accession>
    <name>A0AA38NKR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TdiD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_317649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793443">
        <property type="protein sequence ID" value="KAJ3782974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="104"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="460" mass="51244" checksum="ED2CE9422A186F3E" modified="2024-01-24" version="1">MTKPDFEPTFEPGTNERQTTRALLPDAVYRNMLSRLSKSRKPAPIRHLFPYENEPGMISMLAGKPNASVFPFVSLTMKVRSSNPRIDDSLTDLSLDGQDLAVALQYGATSGNPELVKWLTDLTCHLHGSQLDEGWRVTIGSGSQDLLYKTFAALVEFDDVIFLESPTYPGVLPIVQALGCNIIEIPSDADGIDPASMASLLTDWPKDKPYPKLLYTIPFGSNPSGSTTTLSRRLEVLRLARAYNFLILEDDPYYHLYYGDIPQPPSYFALERKVNGELGRVLRFDSFSKIVAGGLRLGWATGPEVLVNAIDLHGSSSNLQASGMSQMLVLRLLRHWGIEGFLAHTAMCAQFYREKRDLFEQYLQKHLKGVAEWSPPNASMFYWIKLRLPASMKAENIENDEGDSLLFLTEKAIPGGVLVLPGECAYADGRRICNVRVSFSLLDEGSMDEGLRRLGSLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL92</accession>
    <name>A0AA38NL92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_306966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL92"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="469" mass="53195" checksum="66FF2B5BA711A8EB" modified="2024-01-24" version="1">MINFIDLPLDLLPVILHHLALPQHFHKICLVNKTFNRFATPKLYERISVYSWHKHGKEKVILLFLSLSRYPHVAQHVRRLELRDFPKYLGSSDGTDTLEMVVDGLKNCINLHSCTWTRDGSLNSRILEALQCSQSLQTLEINGRDAGNYDPQLLLRFIGLRKISLIMPSSSVISVLRPWLQKTGTSLTSLTIICKTSPIITDAKLELVAPYLSRLKHFHLTGCSKVTHEGIESILSANGDGIVSLGLEGLSPNFDVSQFRLYCARTNAFRRLRSITLTVNHQTPLNNWMNEIAALLPASVPLETFQVYSSGKFMEDPATERLWSDLVIAHQDHLTRFSIHRILISLNIIEDICRRCTRLEQLFVVIEQGSLGKLGTCLALAQNLRVIHVNYPMKASQGENAIPVLSELDAQEIIERCNSNITQFGCNTRVWQVNREILLDRHGAPIGIKRRVMRYEGLDIPEPFLVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLA2</accession>
    <name>A0AA38NLA2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_41442</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793399">
        <property type="protein sequence ID" value="KAJ3783889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLA2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="198"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="466"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="860"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="796"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="897"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3783889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="103885" checksum="E540319FF431A3F1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLD3</accession>
    <name>A0AA38NLD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_388257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLD3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="295" mass="31258" checksum="2DCAF3309DDB259F" modified="2024-01-24" version="1">MSALNRSIALAGAGAIGIPILRALLNHPNHPKVVVLTRPGSKKDLPSDLSSATVIPVDSTDVAALTALFKEHSIEVVISTVPPPGYVTAQHALADAAKASGSVKLFVPSEWGVPTEGAKGEGNLFGVKDEVAEYLKSIGLPYTRIFTGLFTSFIPWVIGADTESSAYIQGTGKTPFTTTSEEDIGGFVAHVLTSLPLTSPDLVNTSLRIQGQKITLQECARFLNKSIVHVAEGESIPAKTDEEKHFKALVQTQMEGGMASTGWDRRTNREIEGATGSANKLWEGHVWQTVGSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLH6</accession>
    <name>A0AA38NLH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_409469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLH6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="474" mass="54807" checksum="1A4B7E1485F6E731" modified="2024-01-24" version="1">MANPNLPSGRNESLQNCLKQLTPITNVINSGIHKSGVNVEERKRKRRDSADESFIGNNRRGGEFMKTARVERVKTTRSRHGGKQPCLRPASSARKEYLNYDEGQYVTFDDLEGPRTVLVGESLFNSEGGTFVAVAECTCLSCEPTWCSWAGKDVVVKCHNTMDHTRIPGEYLIDFVREYAEDSSGEEWALAHLPLVLEKLGNRDFRGRLMRITIYERLYPISDLVDPREIAQVFYDILQIHQWLFDHPGILHRDINLDNIMFRRIDGDVYGVLNDFDLACRVNPSWNLEDGPSPNGCTGTKPFMAHDLLSTDQKRHMPRHDMESLFYAMLILICCYQRPGLMVPEPMPFLNWFNGTEREVHDAKLDFILRPINLPVQPHFCGFRAWIRELYSWLHRGHAEGRQHDDLCECRDGVDTNVDQDTEDSDNSSDTEDVDDMEEENVPFNWYTLNGEFSYERMKFLMSFFQARELETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLN3</accession>
    <name>A0AA38NLN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_425809</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000468">
        <property type="entry name" value="Short-chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="339" mass="37643" checksum="AFCB592AE05A7CB5" modified="2024-01-24" version="1">MLQYLGLENGVITLILSTLFLALWKMWPTKKWDPRGQFCYVTGGSSGLGLAVAIALTKRGAHVTIVARNEERLAKALAELEKTRQSSNQILRSYSFSLTDADASYEALEAASKDHGNRYPDAVFMCAGAARPGFFVEEDAKSMQKGMDNTYWIQAYTALAYTKRLVRSQTSGKLVFTCSILGYMSLIGYSTYSPGKHALRGLAESLRSELILYNSSVHIMFSGNIDSPGYVEENRTKPKITLEIESTDKPTAPDVLAKELIYGVQRGDFHIAPDMLSNIIRSSTTGATPHHNVLLDVLYALIGWIGLPLWRRGVDSTVLKHRKEHKDYLAARGFFKSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLV8</accession>
    <name>A0AA38NLV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_5689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="175" mass="18918" checksum="2ACCE71A67FDBECB" modified="2024-01-24" version="1">MSISLEYSSLESTTRWRNLPPPPGFSKAVSSTKGNSKAIAASSPTPEAYDQLKDKRAWDLAISPAKSLPMQFFMLYMSGSGVQIFSMGIIFMLLSSPFKNIASMNEAFASFAPSASKSPKSLSTLTLQKLAYFACNLLTLGVGLWKCRSMGLLPTGTGDWLAFETRGLAPELSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMA2</accession>
    <name>A0AA38NMA2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_268105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3785989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMA2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="118"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="233" mass="26056" checksum="FAB37480B4FFDE7A" modified="2024-01-24" version="1">MTFEFNCLVLDSHPSINRIFAVQISETDTVATLKKKIKQEVQPAFEHFPANSLDLWNVSVPIEGLSDTHLHDLQPAQAPLLTVKRLSGLFPNPPPEEHLHIIVRPPAVAAPPDPQPLLELNCLVLGDQLNRIFPVKIPARELVGSLKEVIKEKKHPEFRRIAADKLALWRVSEVVDENLENRLHQADFPTKPLLSPIDELGTVFLDPPVKGRLHIVVGRPENGKLNSLWGSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN50</accession>
    <name>A0AA38NN50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN50"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041311778" evidence="1">
        <location>
            <begin position="27"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="241" mass="27320" checksum="854B6B398714E383" modified="2024-01-24" version="1">MQLLSSAKFYITLLEGFFFFTTTAVAVPIEPDVTMSGALDASSQNRPHISPYAIRTRLENDKVLDKPTGLEGNLFVHTTLYDYPESFTTAFTSAVEEMLKPTIPNVVAAIRTYHPNLKFEQTLPNIPITRLTENKTSPANLYDFHITFSGYDKKGKHWSMNHPDEVPYFGEIDQKCLEKRGANYWYRRELLTGKIGRYYPQEEVLVSFKDGKQIITKPAGAAWTKGKSWFKGKFGKQASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP49</accession>
    <name>A0AA38NP49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_296869</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="MU793440">
        <property type="protein sequence ID" value="KAJ3783035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3783035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="161" mass="17434" checksum="209C317FBFEDE46C" modified="2024-01-24" version="1">MADIINATQWTSVDHVGISEALSQARKSYNEGGIPIGCSLISADGTVLGKGHNQRIQKSSPTLHAEIAAVEDAGRLKASTYRDCTIYTTLSPCSMCTGAILLYKIPRVVIGENKNFSMGGEDLLRQHGVKVVILDDPACTALMAQFIREKPEEWNEDIGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ53</accession>
    <name>A0AA38NQ53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_432440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ53"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="69953" checksum="B69E94A4973EC561" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ55</accession>
    <name>A0AA38NQ55_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_307308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="353" mass="40547" checksum="823D1F4479F7DD00" modified="2024-01-24" version="1">MELFPPQSQSYILAFQFSSWYPVFHSNSIKSTIIRPLSQEFLNYLNADQVFVPKGSEDVSVESSLSDDEDEDEGSADSDENIYEFLELDEKIRAVVKEYGAVFPKLNFSSPKDASWILPASSPLKCTSPADVYLLLKSSDFVSHDLSRSTVFDGCEQVASESYDLELVLRKWYFVDRSRELRCFVRDNALLGISQRDTNYYDFLNDPNTHSKVMNTTMEFWKTKIQPKWKVETSYVFDLLLTRDLSRAHIIDFNPYAPRTDPLLFSYEELKDILSEHRSTDASNDSTSLPQFRVIDSPLHPAASCKAPANQHNMVPFEALSLSNGRDIEDFKEIWEKSIKESLQEEQNNEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ69</accession>
    <name>A0AA38NQ69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_345902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">High affinity uptake of sulfate into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ69"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902434">
        <property type="term" value="P:sulfate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000046">
        <property type="entry name" value="Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="530"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="753" mass="81667" checksum="97FB45CFF3941754" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQG8</accession>
    <name>A0AA38NQG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_66784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041243636" evidence="1">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="20044" checksum="5388C51FBE5748B6" modified="2024-01-24" version="1">MHLYHRTSFRIYFALFLVFVCTAMPFSAYSDAPTSVHLIGEKRTMENELSKSVALEFLRGEQGQAIAGPEVHAKLVRYLDVVADALGFSFSIQRSKAIPFRDPQGIVLFRLTTKEKAEYFGLMAVGSKSNVGREMNAEEQRTIGEEPLTDFKLGLNKGGKWEIGVEMKDGKTVSKTEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQT8</accession>
    <name>A0AA38NQT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_330065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="126" mass="13919" checksum="E383AE68B9656416" modified="2024-01-24" version="1">MASHAIAQHAACFSIMLLIPMVPNNVALVVSITLAISSAILQYICPDMDDSLQSIEAGVNIMENSISICHVGDVKLHGQLERLSEPELRLCSVGYLKIWKLNIVANMRVDRDNMNMLNIELKTRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQU5</accession>
    <name>A0AA38NQU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_431755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQU5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111295" checksum="0FC24F273B4D8E43" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRI2</accession>
    <name>A0AA38NRI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_283483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRI2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="16"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="219" mass="23526" checksum="910932FC2CDFB9C1" modified="2024-01-24" version="1">MGSIAGGGSSTTGDDRTEEQKEADKKLAERLSALIEDANSRVVPICKMIRTHIENMDARKDEDKNEDELVRQVKPLLQQAEKILGETEGMVKGADPDNRLSNKAKRHTEAHAATPEEQRLAAALKVMLEEVGGTIEWARNKLDSFPKAKKDLGPLLDALGQPLTQIVGGVMLLLTGVLNLLGKLLSGLGLDSLLKGIVAATGLDKLYNSLGLGKWLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRP4</accession>
    <name>A0AA38NRP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FYVE zinc finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_16309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRP4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="455"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="715"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="812" mass="88445" checksum="ECD5DD88E7E19F93" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRP8</accession>
    <name>A0AA38NRP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High mobility group box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_229931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRP8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="73" mass="8551" checksum="87C0ECA6A9DF08C0" modified="2024-01-24" version="1" fragment="single">VPRPPNAFMLFRSNMLKTKAIPATAEKRQQQLSKVAGECWNLLSPEEKQVWHDEAANQLREHQLKYPNYKFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRR2</accession>
    <name>A0AA38NRR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_283416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRR2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="702" mass="79090" checksum="2CE03783FD99949E" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRX0</accession>
    <name>A0AA38NRX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_303976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRX0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF20">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="277"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="35087" checksum="9D993E1769226C7E" modified="2024-01-24" version="1">MPPRGNEGLDFTPIVTHYLFLFTSLLAVLAWFIAFIGQIIATATRGNGDVGVLWFAIFLQLALILGVLYTLASDSIAMHRFQISVFGAISIVFAVNGVQAGIFTGIGSLDAMSVGWLILAMVDIVWVLYFTSEEDSLALHIFNSMGTGGLTPPSRRRRTRAQSVHNVTNGYGSYASGGGIGPHDMPYNGKMASGMGSGTLASPIGTGNAAVRSQNSFGPSADAANRSLGGGSINNALSGDGPGSSGGGENGPSSPLMASAGANLTQDSPADPAGPETYTYKAKALYAYTQSPDDANEISFTKGELLDIMDKQGKWWQARKSDGTVGIAPSNYLQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSY5</accession>
    <name>A0AA38NSY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_383200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSY5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="518" mass="59859" checksum="9A61015D1BF754D8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU24</accession>
    <name>A0AA38NU24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_64987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="434"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="113"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="241"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="506"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3791078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="673" mass="76894" checksum="6FA51088B8A03338" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUB8</accession>
    <name>A0AA38NUB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_2427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUB8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3791296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="16502" checksum="CD26BBEBDE1C314F" modified="2024-01-24" version="1">MSVCPPYAPFFGFAGVASAMVLSTIGAAFGTAKAGIGIAGLGTFKPELIMKSLIPVVMSGIIAVYGLVVSVLISGALTPEGYPLFAGFIHLGAGLACGLTGLTAGYAIGIVGDACVRAYVQESKVFVSMVLILIFAEVLGLYGLIVALIMNSKVAGGVGEVCYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TXY3</accession>
    <name>A0AA38TXY3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_305522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TXY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000853">
        <property type="entry name" value="Related to ARK1-Actin Regulating Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="549"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="626"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="704"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="849"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="925"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1106"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3789280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1231" mass="134031" checksum="1108E1AAE1D70C3A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TY11</accession>
    <name>A0AA38TY11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caleosin related protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_343835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TY11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="299" mass="33741" checksum="08D4B2D1D2C3EEA9" modified="2024-01-24" version="1">MAQSDDVYDETGVNDSQAYLNDDSQFADDGHALQVKDDNGHRIIAGESNRDAGEEKTGAGGGEAMVGHGEFFDPDGDGIFSPFDTFNGFRALGYSIILSIFSAMVISTMSYPSLPSGHWLPDPFFRIHVKGLHKAKHGSDSGSFKRDGRFDEERFDEFWDSHTDAPHAEITPFQLYAAVAERRLAYDFYGIFAAIFEWLATWILFGYPSFHFDFKLAFEKIRKLFFGKDRITVDAAEWRKLLADTLQKACSGGNVKKEDVKGLYNGMAFYTVMDWQADAGNEWAKSLKRKHEGNPRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZ11</accession>
    <name>A0AA38TZ11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_252371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZ11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="131"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="322" mass="36438" checksum="F5ABF9C86C184027" modified="2024-01-24" version="1" fragment="single">LVYNPLVDANTLCPYCDESLPSSPTPHLKHLLATTAKKSVRAPRPTNPMGRKAAVSVFINVCQRHRFESKILPEAEAKGWPKSIEWNLIHGRVMRMRKHLEALMENSFFGDTKGGSDSDDSDVHESGSQRMRVRDKCFFWKEVMKEVKEKGTRAAANVKSQFANFQNAQPGYYGELGSILIHQSLCELFPPETTHPDLVSPLSPKEFINRVLLPEVALRLIMEDKLLSGSSGARKSLEILRDSTTYGVAMFPEDTGERGKVTSAELEKGKSKGKGKGKERHRSEDLDNEKTIEMNVADKMVREKARRRRLELEKEDEDEQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZG3</accession>
    <name>A0AA38TZG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_283019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZG3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="158" mass="16721" checksum="50CAF65BCC584986" modified="2024-01-24" version="1">MAPKEYSLCLQKGITGGFAPPTPSFIATITRPIDSDSLNITTASRPDGTPELQNFAPKTLTLGHAAQLTGVSTSAEALIDELHGILKQLPTEQPPGSEDIYGLDISIFWGSNDLQWMNGGMNGVNGQPGSSSVQATPEQKAQFKRAVEIVEVLVGEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZQ1</accession>
    <name>A0AA38TZQ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZQ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="696" mass="76832" checksum="D0641D98B7718923" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U170</accession>
    <name>A0AA38U170_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_341352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U170"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="730" mass="81763" checksum="61A732CA0FE5702E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U542</accession>
    <name>A0AA38U542_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonase, 7-bladed beta-propeller-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U542"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="352" mass="38323" checksum="1D5833525F5CF64A" modified="2024-01-24" version="1">MAFTILGSSYTNSVYTYTFENDSLGLKSSVDVGVHPSWVTSHPEDKSLVFAALEQEEGKIVAIKYDSEYKGNLVAEASSGGQDPCSIVVVKDELLIANYSSGSITVLPVSKNAPYILANSPTYTITLTGSGPNRERQLSSHAHQVFYSEEYDDVLTPDLGGDRVYRLKKDAVGTWKIAGHVEHEAGGGPRHVAVHNGYLYTLLELESSIAKHLFPRSLDSDVELIAKVSTMYNPPPSPNDMLAAEILIPKPNATYPIPYMYVSNRNHPSPEGDSVAIFSLEKPDGPELIAEVRTGLRHLRGMEFGGPGDKYLCAGGLYAGGIRIFERTEGGRNLKLVAQDPSIKSPTGFLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U558</accession>
    <name>A0AA38U558_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIPSNAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_284689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U558"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="163"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="262" mass="30269" checksum="410CE3D496A72522" modified="2024-01-24" version="1">MFRRPVTNLLTTASRRSISVKHILHGSPEAQQAGEIDVQQHSKLVGRGKYVHGFEFHCIKPDKTQEYKEAAENYYTGLIRDPNLHVKLSGSWETLVGQQDTFLHILEYENYGGYDKTVQLVKNSKHFKDYEAMLPYMNSRSLQLNQEFAFLPTAPPHAQGGIFELRSYQLIPGTLLAWENAWRKGIDARRKHVAPVGAWFSQVGRLHQVHHMWQYPNLESRKETREKAWQIDGWAETVDKTSQLAKFMDSFILSPLSYSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7A3</accession>
    <name>A0AA38K7A3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mon2/Sec7/BIG1-like HUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_46235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794873">
        <property type="protein sequence ID" value="KAJ3779454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7A3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="2">
        <location>
            <begin position="53"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="298" mass="32537" checksum="66349F07AF2FA9C6" modified="2024-01-24" version="1" fragment="single">MSVSATQIPSEIGEEDRHEAAVDASPAPEEEEPKGTQSPSSVVPRTQFSLPSILELLRVLVNVLDPNDQQHTDSTRLVVLGILNSALEEAGPRIGDFPSLKALILDPACKYLFQLARSENLTVLHAALRAISTMFDTMHEHLKLQQELFLAFTIDRLAPPPIANAKGVLSKKAGVTDSPQPGTPTLGPIESEKDGENGSATPTRILVAPARGETRNLVLETLSQISRHPSFMVDLYTNYGCDINCENLFDRLIDFLTKSVYPAHYPAGLDAQQRNAQYLCLDLLLAFVNDMAKRAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K860</accession>
    <name>A0AA38K860_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_367128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793572">
        <property type="protein sequence ID" value="KAJ3781329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K860"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000033">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="340"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="640"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3781329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="811" mass="88624" checksum="0EFD82770B2F674B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8A7</accession>
    <name>A0AA38K8A7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 90-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_366205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793540">
        <property type="protein sequence ID" value="KAJ3781614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8A7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="333"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="650" mass="75859" checksum="70C8EA163ED307C5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8Z2</accession>
    <name>A0AA38K8Z2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793431">
        <property type="protein sequence ID" value="KAJ3783204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8Z2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="37774" checksum="74DED19C02C4C0BC" modified="2024-01-24" version="1">MASPILKLSLALQAAFNDPEVLIYTKGVAFEKLESLMHAVMSKDSNESHLYGLLFRWLSDICIASFPVVQGQDNSKPVPQLECYNQADYRVTEEGTTRSIRIPDYTVFVVDSQLRPAFTVEVKPLAFKDPGIRDWRLNPESRKDALVHFGNTISQLREQAQYVFATYPYLQEHYAFLQVGYFFSVLLFKKENEKKVCDLETPILMGEPVNSYNEVFRYVISIVLKKHGFVLQNSWLSPPEAGYDFPEFEEERNIWGEYLLKGYSAKIGSHMDHRKQERAVDEQLTPENLKDADYIGPPTTPTPSHRTLRNRSTTAASSSSTRGGRGRRTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K913</accession>
    <name>A0AA38K913_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_361103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793423">
        <property type="protein sequence ID" value="KAJ3783354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K913"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="81" mass="9101" checksum="7CAA69F1F8765F0C" modified="2024-01-24" version="1" fragment="single">MDRPLVCRHHRAFSACGHLACYAMVIVEVKHLHKPVTSSSEVSLYLLSFALCVLGFYLGFTFCICFRAADLPTNPKNGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA80</accession>
    <name>A0AA38KA80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_291876</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="69"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3785634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="471" mass="51650" checksum="6E05DBEFC4F19F41" modified="2024-01-24" version="1">MCNHDNGDSQPQDVSEMVEVPLTNGATNGHVNGKRSPSRNPHLTNFIESQRRNPYAPRASDFLSNISNFNIIESTLREGEQFANAFFDTKTKIAIAKALDAFGVEYIELTSPAASEQSRADCEAICKLGLKAKILTHIRCHMDDARIAVETGVDGVDVVIGTSSFLREFSHGKDMTYITKTAIEVINFVKSKGIEVRFSSEDSFRSDLVDLLSIYQTVDKIGVNRVGIADTVGCANPRQVYDLVRTLRGVVHCDIEIHLHNDTGMAIANAYTALEAGATHIDTSVLGIGERVGITPLGGLVACLYAANPEYVKSKYNLPMLREIENLVAEAVEVNVPFMNPITGYCAFTHKAGIHAKAILNNPSTYEILKPEDFGLTRYVSIGHRLTGWNAVKSRVEQLGLKLTDDEIKDATAKIKELADVRTQSMDDVDSLLRVYHSGIQSGELAVGQKEALDRLLSKHRSQSQDRALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA89</accession>
    <name>A0AA38KA89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_191849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47048">
        <property type="entry name" value="PROTEIN SCAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47048:SF1">
        <property type="entry name" value="PROTEIN SCAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="100560" checksum="C1E704FB49CB5E2A" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAB3</accession>
    <name>A0AA38KAB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_375436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="786" mass="86766" checksum="88B0755BBAABDB6F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB21</accession>
    <name>A0AA38KB21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Urease</fullName>
            <ecNumber evidence="3 11">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_349519</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a nutritional role via nitrogen acquisition in the environment. Contributes to the central nervous system invasion by enhancing yeast sequestration within microcapillary beds (such as within the brain) during hematogenous spread, thereby facilitating blood-to-brain invasion by C.neoformans. Affects fitness within the mammalian phagosome, promoting non-lytic exocytosis while delaying intracellular replication and thus reducing phagolysosomal membrane damage, events that could facilitate cryptococcal dissemination when transported inside macrophages. Urease activity is also associated with the regulation of key intracellular metabolic pathways, including melanin biosynthesis, polyamine biosynthesis, as well as intracellular levels of proline and reactive oxygen species.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="13">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB21"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0533">Nickel</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Urease" evidence="16">
        <location>
            <begin position="398"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14 15">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="12">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3787194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="850" mass="91491" checksum="1311B656A78BC9A6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBX5</accession>
    <name>A0AA38KBX5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_134650</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MU793661">
        <property type="protein sequence ID" value="KAJ3780748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000003">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="696"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="789"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="881"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="973"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1065"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1157"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1250"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="1324"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1724"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3780748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1866" mass="200616" checksum="047B80F637221EAB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCF0</accession>
    <name>A0AA38KCF0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_390468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793536">
        <property type="protein sequence ID" value="KAJ3781648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCF0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="16"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="44324" checksum="285B28BBC310473E" modified="2024-01-24" version="1">MASKRQQEANWIRLCQMAFSFFVYAQAGMSDGSLGAQLDSLQSHYGLTFSVVSLIFLANAAGWLIASFLNIYLQSHLHFWKTLVIAAMTNIVGSTVIITLPPFPVFVVALFINGIGACIYDASFATYTAYFDEGPAMSLLFAAFGVGALIAPLIVAAMLVHHVSWNMYYYVSLGLSLLNMPLLWILFRKYRFPEGENASTGAQKRFIPVLQNRNVLTGGMLTTLSMASGEVVSSWIVTFMTDIRGGNDDAMRYVLSGYWVGLVLGRLLLVHATSYIGPKLALTIYGIITIGLLAVIQSVDNVAVNAVATALVGFFQAPSTPMIISLSSKWVPASLVSPAISILTAFGLVGSALGPLCVGFVNSAGGLRYLPSITMGIMGLSLGIWHLAPSAPWKTGTVDSNQNIGAKSELSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCK7</accession>
    <name>A0AA38KCK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_364958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793507">
        <property type="protein sequence ID" value="KAJ3782008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCK7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="745"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="860" mass="87897" checksum="49C1D6226C5470BE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCR7</accession>
    <name>A0AA38KCR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_335622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793482">
        <property type="protein sequence ID" value="KAJ3782353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCR7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="128"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="601"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="677" mass="74511" checksum="F6747031546DDAAE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDC5</accession>
    <name>A0AA38KDC5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_235267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793424">
        <property type="protein sequence ID" value="KAJ3783343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDC5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="2">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="114" mass="12910" checksum="16B3C4E8FED3458E" modified="2024-01-24" version="1" fragment="single">SSADQDRRFSEKELKLLKSMKFPPEFDKKVGKLDSVDMRKVNLTVIRPWIAKKVVEIVGFEDEAVVEHAMGLLEDKQEGPTPDPKKMQIILTGILAEDTPAFMSALWNLLLEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDK3</accession>
    <name>A0AA38KDK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_435801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDK3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="659" mass="74811" checksum="368496670F0CCA95" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE56</accession>
    <name>A0AA38KE56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sec61beta family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_376428</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793364">
        <property type="protein sequence ID" value="KAJ3784783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE56"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="119" mass="12919" checksum="059E6F58A6F82220" modified="2024-01-24" version="1">MSHDLELINKRHLVSVPANFFILNYGHPRSPVTRSTASSVAKPPGAQIRRRATGNQAAKPNSTRAAGAGGSSNTMLKLYTDDSPGLRVDPFIVLVLSLVFIGSIFFLHISAKVIRMFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEH7</accession>
    <name>A0AA38KEH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_5305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="190" mass="21510" checksum="0DEE2A59084A8D02" modified="2024-01-24" version="1">MSEPQTDVSRPSALPTATLLHRTIPQAIIDQNSDEYLDNIEEEWNKKVDLEVETLVDGMVDLVGLASVRGTSLFFEGWFKQTHYRSAIKISFELLRNPSKHRPVRNRWQVDIVPGTFSSSSYFPSSLRQVRAANTLISITHSMKLLLLLSDEAQIAHRRDAELKVVQEEKAKAKEQVAVLLDELLRGATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KER0</accession>
    <name>A0AA38KER0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_291733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1362" mass="150017" checksum="01FEE891F2ABFA52" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEY8</accession>
    <name>A0AA38KEY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_421174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793328">
        <property type="protein sequence ID" value="KAJ3785908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEY8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="510" mass="57475" checksum="75573F6916C1E089" modified="2024-01-24" version="1">MTSYLELVPRDILEYIAFLVVSTPETLFRPPQELLNLLLTSSTLYYSLCTSSAPHLYARIFRSTFDLGQNGIYSTENRLTDSELTLDCVSRHGLLRRVRRRDFSNKMMFEDLCVAMRIIIESAGVNEAHLRSAGFSDFIFTYARRCLNKQQLACTRTNLDCETSLVLWLLALTWSRDDVSEISPELREHFLSLLRPFVLGPTATSRMFERASSFATSAAIILYFALQEASAIKVTPRLLFGRIIDQRDGREGPTMEDYCRMTNYQTPLFGDDCPAPETAKPKLSSSIRHDPQFFNPKLPGSNAYCYLPDIITGLWEGVYMVSCTHMDKEAPFSPNAPDFICKKSMQCSLALFFYFGTPDSDILVPRSIGDEVSQWTAMPRDFSTELDCLTVSGRKTPYEKFVSSASGKCQVFRNYSQALDCLVIGQTAQDHDRAWGGFNFAGRLKRNGTIVMKREPKNSSDASLGTWIFEGNVRYGSVFAGKWRSNIRSASGINGLFSLEKTVTPSQDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF63</accession>
    <name>A0AA38KF63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_295793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793411">
        <property type="protein sequence ID" value="KAJ3783626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF63"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="127" mass="13431" checksum="246C20514ADE2FCD" modified="2024-01-24" version="1">MSNEPSSSGQQSAQLLYAPNVQHNNLTLTSIRFISAVFAGAVAGILGLTNFAGFGLFALAMLWSAFCVYVVCCKGKPGKYMTSAVTAKTSNGSSGSGIMELLNPGSDNAFTFVLVWTLFYGIVHVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFL3</accession>
    <name>A0AA38KFL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_271759</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MU793382">
        <property type="protein sequence ID" value="KAJ3784301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="122"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="882"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1218"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="602"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3784301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1583" mass="176261" checksum="98721CEB35B8C04B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGI1</accession>
    <name>A0AA38KGI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_394914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793328">
        <property type="protein sequence ID" value="KAJ3785921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="412" mass="45278" checksum="1F4A15959A53C2F0" modified="2024-01-24" version="1">MSAKYNLRDSKTIIDFSVPTTPTPVSSTSDAPAEAPLPASLPLTCSSKSVLYFTRGNRVHFKNMQTNEDIGQLFKLPDKDGNLQLLQCGGAQNSDVLAISTTKGIIQLWDVRAKKMTASWSTKGVGAMQFNGSVLTVGGLKGTLRFYDTRIAMSTPTTTTNAATAKATFKMKSDLRKLNRHQSRITALAWNEPGKLLASGDESGVVYCWDNREKVPLDVGEFVQRRKKIQHLVSVTVVNWCPWQPKLLGTGDANGTLRLWDIDTSDSRSNALNPGKLELGSRITGLHFSPHCKEMITVHGINERAPSGPDIEFDSETSSTPSISTLSPMTLSAAQMRSRTYDTSNSIVAHSFPTLRHIYTLPAANKVIMGSVMNANFTKAILAIPEESKLKVYDVWGRLHLRRTESFMGNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGN6</accession>
    <name>A0AA38KGN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_105448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="18213" checksum="5A05CB00502EE3FE" modified="2024-01-24" version="1">MPRKSYSSSSSTSQLERSFCAPPIPKRRSSLRLCKAKTVDIPIPPSLLQSPHLNSPMSPFRRAASTYCVPNHEDERWLRDTVPLTASSTSLGRSSSTKENTRRTSRPQKPYTEDHVRKFGFGPCSPPLLVRLGKRQPSQERLDKGPLCTYLVRENKDTSSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH04</accession>
    <name>A0AA38KH04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_408116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="313" mass="33571" checksum="7DD38816C0DAF0CE" modified="2024-01-24" version="1">MTTPTCEVPTTIAHHTDFSLPILIICSYLAFSFDMDGTLIDSSPAVAAAWKLLKETGYEFLDLDHILRSAHGYRTIDALRKWCKIKDEELLKREVVRFENAILSNAQAKAGSGGGIIALPGVSQLLDDIEASIDSQHATHFYASQALPAAGLRIPKVFVTAESVTQGKPAPDPYLLGAKLNNVSPFDCIVVEDAPTGIRSGKASGALVLATCTSHTRESLERESPDFLVPNLSYVKASRNPDGSVTLAIAQPADRKETAPTPDDTPLHTPTLSRVPSATDIFKKIHSGVATPRESGTEIDDYGARGIKAMSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKJ9</accession>
    <name>A0AA38KKJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_279590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793788">
        <property type="protein sequence ID" value="KAJ3780329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKJ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="68" mass="7893" checksum="BB5F82C6B0A57AC9" modified="2024-01-24" version="1" fragment="single">SCGLYYKLHGSARPINMKSEVTRKRSRHDAHAAMQARSFLEQRAGMVTFTEVNVTPFLFLWIFTDIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL56</accession>
    <name>A0AA38KL56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_391252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793745">
        <property type="protein sequence ID" value="KAJ3780420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL56"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="11">
        <location>
            <begin position="217"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3780420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="716" mass="76912" checksum="FE26AD7B244E4DE5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLB6</accession>
    <name>A0AA38KLB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_369069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793691">
        <property type="protein sequence ID" value="KAJ3780600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLB6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="235" mass="26178" checksum="F34B6AA2462CF2D6" modified="2024-01-24" version="1">MAIDSTWYKYEMRFRSSSFSNKLEGFDTLRPDYPYYPVLIQPLGAPAMSNIAKLVTITPLHKPHVPSSPVYNVPLAPRNVPEDLVDDSLEFMSTLEPPKSDIWSRFSSPGGFFDESGYYFPPIDPPMDPEEMKEFAEKYFSPESGFSSADQAVFFLDDSESTRRDGTLPDLLSAGFDSPQSSEELEQFLLALTSSEWPDVMSALDIDTEVFGEVSAAVESIPENTTTSEMMGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLF6</accession>
    <name>A0AA38KLF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_366346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793544">
        <property type="protein sequence ID" value="KAJ3781574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041293245" evidence="3">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="273" mass="28044" checksum="F13F2EF6437882B2" modified="2024-01-24" version="1">MFSSQIAAAAVFLALPFASFAESHGNAHQNRHHEIAKRASNNVEVYKRDTFTNARWTFFADGLGACGTTNSPSDYIVALNSEQYGSGTYCYQTITMTYNGKTTTAQVTDECPGCPYGGLDLSTGLFDFFADESEGVLYGTWYFNDGSSGDTSSSSSYTPTSTSVYTPPPSSTWTPDSTTATPTSTTPTTTWTPSSTSSSWSSSSSSSSSSSSSSSSSSSFSSSSSSSFSSSSASSASSASAASSASPSATAGTLNSLEQVVLNFAGVIAAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMI1</accession>
    <name>A0AA38KMI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_429179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793436">
        <property type="protein sequence ID" value="KAJ3783104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046503">
        <property type="term" value="P:glycerolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="48"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="363" mass="40447" checksum="8DB9A57786FCE7B1" modified="2024-01-24" version="1">MPYVEVTSSTGKTIFKYTICTPASEEANEIDKGLPTLLFIHPVSIAEHIFHAQFNDPQLRRFNLVSFDLRGGHGGTTGDRVPTHYGQAEAAEDTIKLMDALHLPPCHFVAMSSGTTIAVQIAVTEPERVLSLFLISHLCLEIPPEIAEGHQEVYDLWASAFPNESTVLIDTIYDAGFGNSQYMFTTPQLSPLVTAMIRITYPVAMVKWSYHYLDQFRVMNLDFYLNRKSHTKSALARIIGSVKLVHGSEDIAYPRSYSEEFLKHLNKAGVDASLLEVPGAPHYLSPDYATFIDPVIHDFILQNDEFDLLLHTPVPSHVVSPWEDAMRQAGWESDNGSSDSSDTDNFDDIMCNHTLAEISGSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN40</accession>
    <name>A0AA38KN40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SART-1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_362162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793441">
        <property type="protein sequence ID" value="KAJ3783015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN40"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="779" mass="87315" checksum="E7584D8A7C137D01" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNC6</accession>
    <name>A0AA38KNC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793687">
        <property type="protein sequence ID" value="KAJ3780621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="299" mass="33287" checksum="CC45C09AFDEAC3F1" modified="2024-01-24" version="1">MSRATPPGTGGETMTVGGRGSSKSRGEEARGGGDSSRSRGEETRGGKVFGRGTKDERRMTSGRGERIVEERRVVEEQKRKQEALAEKRKNKEVQLVEAKQREAERVAEEAATEVEENQARNTAYAKLVEENKKEKEKAAKELAKWQKHVPATKQRQVDVVIPPRPLGSKKKHFKSKSVISDKSDEEGREVVPAPQGEKRKQMVRMIPKGGILSNLDGEYDPENEQGTERHPDAPSPSRPACSQCIMIGRPSECRPQSLQRQAQALRAKWVKLDDEGYEGPAARVGESVTIMRTSRTHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP18</accession>
    <name>A0AA38KP18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793568">
        <property type="protein sequence ID" value="KAJ3781371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP18"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="77" mass="8542" checksum="2E442BAA94A5B58E" modified="2024-01-24" version="1">MIHSLITMVSVAITVHSLFIPSPAWYLVVSFRSGPQGPELKLSFIHGHIPTTNTSIFSTYGSSRVAREIEIVFPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP89</accession>
    <name>A0AA38KP89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_437205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793542">
        <property type="protein sequence ID" value="KAJ3781596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="274" mass="30991" checksum="95C0910761D26C77" modified="2024-01-24" version="1">MESSIADVESLYRLRYLSGVALIVMVYDHLLTLDDEFSTIWANTNREYLQKLMFVVNRYYTEAMVIYVVYVSSGLASLDDAVCRRFIWVFALTSTIFTATTHFFITLRLYHSWDKRKRMAIILLIAFTAFISAAAVLAVISAVQVQSVIYFISLLRACVIPDIPTTLPYMMGTLFGFDLFIILLALFNAFERPHKTHADVLDALHRDGARLFLAVFLMRLFCLIISIIGLPADCFGALNVMWTLTAIISSRIHLRVEGLKFATLGWGSSALVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPG1</accession>
    <name>A0AA38KPG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_428532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPG1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="642" mass="72518" checksum="6DFB605EBDCB95DB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPR4</accession>
    <name>A0AA38KPR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_388097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793367">
        <property type="protein sequence ID" value="KAJ3784680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="808"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="883"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1158" mass="124495" checksum="F0843E8ED8A4483F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQI2</accession>
    <name>A0AA38KQI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_405072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793428">
        <property type="protein sequence ID" value="KAJ3783261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQI2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="756" mass="84275" checksum="DE2824374EF42713" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR87</accession>
    <name>A0AA38KR87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_428634</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="MU793387">
        <property type="protein sequence ID" value="KAJ3784176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="462"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3784176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="773" mass="88018" checksum="F38827ADB1C3F80F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRR8</accession>
    <name>A0AA38KRR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protoglobin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_356612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793361">
        <property type="protein sequence ID" value="KAJ3784866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRR8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="74"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="262" mass="29692" checksum="1459FD68DFA76085" modified="2024-01-24" version="1">MISMSPVPVENTTPQIDIGSLSLGDTDSQRTPHADKPTCPFPHELKTELGSCPLNVNPSTQEISPTLLRTSLPDRINYLKDFILFRHTDEEILHKVAPLVNDLIPKVVDELYAKLFEFDVTKVIFLQRNEGFDGPLPTKLEDLTLDSPQLIYRKIFMKSWARRVLTSDYSDPAGKTWSYMDKVGIMHTGVKAFRHREGVKPLVVPYRDCALSLGWVQTVLQTAILKLDEGELSMEEKIGAVSAVSKVIWIQNDLFARHYIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRY6</accession>
    <name>A0AA38KRY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_346276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="40"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="19873" checksum="D0139529ED9F6DF0" modified="2024-01-24" version="1">MSIARQLLNEFRPLFRMLEEPITRSPALRYNSIFNDPFFNSPALARPAVDVSEEGNKYIIEAELPGVPKENVDVRIGNHGHSVTIEGKVTNRRGGPASAPAPENGNASETTAGDTTTTVTNQAEPNNQLSTERQLINNTSFTRTVWLSRPVDGSTVTAQLKDGVLTLSLPKSEDKGSVKISVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS09</accession>
    <name>A0AA38KS09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="5">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_144325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="5"/>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS09"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="536" mass="61029" checksum="A978498271FFD088" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSM1</accession>
    <name>A0AA38KSM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_353379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793328">
        <property type="protein sequence ID" value="KAJ3785931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSM1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="98"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="268" mass="29735" checksum="1B3DB3826C977183" modified="2024-01-24" version="1">MPSTIDLQAQAVDEDGEVFYIPNFVTEEEESYLIRKINDTPHQSWKSLANRRLQIWGGLMTGKNVLLSQSLPPFVEVYPNVIDRLQSTGAFCASTHGAPNHIIVNEYLPGQGIMPHQDGPAYHPVVATISLGSHTAFHYYRYRTGSPSQAATDVFSPGPEGEARIIDHTPVMSVLLEPRSVIITSGSMYTSHLHGIGNEIVDYFTAGSDDTDPPKFADFNVAVANWRLLGRKDTKEAVINGRFLQRSIRYSLTCRDVEKAANSALFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSZ2</accession>
    <name>A0AA38KSZ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794078">
        <property type="protein sequence ID" value="KAJ3779907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="222" mass="25217" checksum="4BB2AF55495D08D4" modified="2024-01-24" version="1">MVHSGKFCSNKDQLVHIGCPLGKLEIRIHPSRRKRGWVEVIPVSNICNMPSGGVRTKAVPAKPREAQGLYLIASSNDVKTHDHVRKLVRRVREARVDESPFAESSESMYLCQRVNLHQVAGRGLNYEEEIIENKEPFVIHYTHLLSFHQMDHINSEGNKKMYKIRTAYGGLTMLCDEPEGTQAQKDMSNDIAQLEEQIRCARRTPPPPLQPTPVDWDSISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT45</accession>
    <name>A0AA38KT45_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_95385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT45"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="226" mass="24900" checksum="9C272E4FC5653A5F" modified="2024-01-24" version="1">MSAKQPPQKASPHQYLSSQFEQSRTDVTKYAAWIEQKYARPALQNMQSYYREHPLVSIFAAVFMLLSLLPIATYIGLCLIILISLLLSALCAVVVVFTTIALALGSILLLVVLTNLLLSIFVTFSLVAAYFSFKIASACYQNGLNAARLQFIELYDAFFSRVQTTVDQKSSQHSTSASGEAITHEAHEGSRSSSPDSTVIVNSSGTNYGTPNFENLPTAMKFEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU00</accession>
    <name>A0AA38KU00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_367139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793572">
        <property type="protein sequence ID" value="KAJ3781332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041340638" evidence="1">
        <location>
            <begin position="29"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="213"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="321" mass="37101" checksum="D90DD0E3BA8AC9D3" modified="2024-01-24" version="1">MKPHNGRAEWLLCTLLCTAADFLDTVLSTVMPNSKPHISFLPSDVDNMKDKEILELRTKAPKLHKDYNVRKLTPGTVAKASQDMDEDMSDASEANALNLVFAKTTIPVPRVRRVIKREWDYLIVSDYIKGPLLVDVWSTYSIWKKVCVAFTLRRYVRQLRQLKASPTTPPGPIGADGPRQCESPIFGQIQSRRGPFSSYAELTTFFNERAKMGYNAKKLPEDHPSRKQRFDDSEALVFTHQDINPRNIIVGEDGRLWMIDWGWAGYYPPWFEYVAMQRQLQNEEVGGYYHKYWDLLIPFVCGPYFAQEKWLALMSRGLYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVW5</accession>
    <name>A0AA38KVW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_387967</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="MU793361">
        <property type="protein sequence ID" value="KAJ3784872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVW5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="19">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="605"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3784872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="832" mass="94613" checksum="637440F9CFB4C630" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW87</accession>
    <name>A0AA38KW87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793975">
        <property type="protein sequence ID" value="KAJ3780023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="230" mass="25656" checksum="86C48AEF74C78AB0" modified="2024-01-24" version="1">MLGPSYSLLGSVKALDNSINTLAFSKDGRYLASGGDDMCVHVYDVRRNLSVIWTYRSKSPFTTVIWHRDYLFAGNSDGEILMLRPTAYWFQKGCEQLIAELYNPIHSLEFDQIGNQLLVCSGSRTTLLVERKSRQWKLRCHFDSPGSFSEIPEFGEPDGFEEPPVLATSAHFLEEKGCIVVGYLHHGLWKYQTEDGTSVLVWGPDEKIGSTALSPDGTALVATNIRSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWQ6</accession>
    <name>A0AA38KWQ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_394622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWQ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="141" mass="15696" checksum="1F11BD72997FD94D" modified="2024-01-24" version="1">MRLNAERCLFCMIVKGTIPSFKVYETEHSLAFLDISPVSEGHTQVIPKYHAVTIADLPDEYLADIGPVVKKVALATGASAYNVLQNNGKIAFQHVDHVHYHVIPKTSEKDGLILDIDVSWPQKKAEKEELAATLDKMKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWX6</accession>
    <name>A0AA38KWX6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_278095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="MU793595">
        <property type="protein sequence ID" value="KAJ3781148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWX6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="10">
        <location>
            <begin position="191"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3781148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="312" mass="35771" checksum="A718A91F1888091D" modified="2024-01-24" version="1">MFSHCRLDEMGLIDDHEGPKLVDLEKYKLGKAVVRKKELFLRIDGTSIYLTRDIGGAVERYEKYKFDKMIYVIPSQQDLHVAQFFKVLELMEFPWAKDRVHVNYGLVLGMSTRKGTVIFLNQIIKEATTVMHEQMQKNEEKYNAVEGPEMTSEELGITGIKIQDMAAKRISNYTFNWDRMLFFEGDTGPYLQYAHLRLASISRKNPHLLPLPPPSEINIDPLITSAHAREIAFLLGTYSDVVKTVLKTHELSGVVTFAFRLSHAISSAWETVIVKGEEDIEKAKARMWLYESARDVLAASMELLGIRPLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX43</accession>
    <name>A0AA38KX43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_350034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3787002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX43"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19642" checksum="71E4BA0B89A69DDC" modified="2024-01-24" version="1">MTFAEIPGQELAMQGSLPANYTPPQAPYSGYRIPLNENSAFPPALHPFSYDADGVSPIFIGSAILPNSVHPCKIVPAWDPKCMFPYAGKEQHHRGRYDLLPFDANTMECVRTSHGQIPAGRSPIAGGYEDKGDKLYHGIATVSGVRVPGKTGLHLGGCNVSFAGEEHIIRENYDILCWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY95</accession>
    <name>A0AA38KY95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_285429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY95"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="364" mass="42097" checksum="65D058A89D183231" modified="2024-01-24" version="1">MLDISEVASSFHELKVCSENDTARFAGETSRTEDDEPLLKGSQKRFVLFPIQFKDIWQMYKKAEASFWTSEEIDLSHDLVDWNQRLNNKERHFITHVLAFFAASDGIVNENLVERFSNEVQTAEARCFYGFQIMMENIHSETYSLLIDTYVKDAQQREYLFDAIETIPCIKRKADWALKWISDKQSTFAERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTYSNELISRDEGLHTDFACLLFNHLKRKPHPRIIRKIITEAVAIEQAFLSDALPVSLIGMNAGLMRRYIEFVADRLLAALGNEKYYHSTNPFDFMDMISLQGKTNFFEKRVSEYSKASINHSTTSSTRSMEPNRTFTMDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYT9</accession>
    <name>A0AA38KYT9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_435465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYT9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3784163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="20372" checksum="FFC5237046D05382" modified="2024-01-24" version="1">MARVPLSSRPLDFVYFCFFLNHIPASILLDFQKFYPAAYVPSSIVGIRQWWIDISADPLVAAAARGDNLLHGELVWFGCFAWLELLFQFPVFILGMRGLWNGSRSIYVLMLAYGASTATTVLPCIVYFLQEHPNMTPAHRLMLLSSYVPFFLVPLMMTVDMGFRMYNIVASAEVKEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZ01</accession>
    <name>A0AA38KZ01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_357583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793373">
        <property type="protein sequence ID" value="KAJ3784523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZ01"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF11">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="50661" checksum="71BCDCA544C1A29B" modified="2024-01-24" version="1">MASLLSWFFSSPKSCPSEEDQRCLLYNQIVQEGGQHHIAARLAELITNSGNAWPPKATHVESWPSALKPYNVVYQRIAPFLPVRESSLDDADNRRLINKTRALIAALLEEEIQIPDICETLEECSRYDSVLMPMSAWLGFYSCLASLRHAYRWGVLPVVREAQNEKYLQFPRELDIPWPYIQRRVGITSPGGSLSSNSYYNLDARREIVYSITSGMGEDHNRTELWNGLLFVEVEDKALPMYRHIAKASQFLENEDYPSTISTLRTANEELKVAFKHFYDNMNDYNLVPSLWLPYCQGFQGWTLEGIDGVSGGQNILIRTLDSFLGIRPWPTEEVEALHLPLAQRNWLNSLRTFDIRALAQKKGNKEVIQELEHMVTQLRLWRMGHMRRMQRYQVHRPERNKMTAGKSLVEEDSVQVSDDSAMVNHLKQMLSVRLKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZD3</accession>
    <name>A0AA38KZD3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_434599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZD3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="47799" checksum="ABA9A3EF16D52DFF" modified="2024-01-24" version="1">MGAVCCCLSEPIDFDGEVNLYHFDLHRAVGKGAFGKVRVVEHKRTKKLYALKYVEKARCIKQKAVANIIQERRLLEEIDHAFVVNLRYAFQDDENCFFVLDLMLGGDLRFHLERKGPLPEKVVAFWLAQLASAIAYLHKQHIIHRDMKPDNVLLDSQGNVHITDFNVAIHYSDRRLHTSVAGSMAYMAPEILGNKGYSWQIDWWSLGITIYELLFNKRPFDGRNVERLKSAISKDSLKFPTDLIPLSDDGTDILKQLIERDPTKRIGCRSTDQLDDFREHPWFGSLEWDRLETKELTAPFIIDLKQANFDVTYELDEFLMVEKPLTHTKRKAHTDLEKLKPELRQLEEQFTVYEYDRSKRQSYYPDNQPVYTMTAASEGVQPTATIAQASRSGSPDVFNSTTRPLNSLHVQYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0F2</accession>
    <name>A0AA38L0F2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_263571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0F2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="980" mass="104775" checksum="02DBDF646045BC28" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0G6</accession>
    <name>A0AA38L0G6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA intron endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_346890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0G6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28582">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28582:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="13676" checksum="C8CA7958BCC7178E" modified="2024-01-24" version="1" fragment="single">MLEIHPSYPALASLVEKYPAHRGSLFQTYNDILLAQQWRDVQVIDLGDCRRGALRGKRPKTATDPESLLHVIPCSLAESISIAWIQNVFSALENPHSIYLAVVSDDSSIVYYKLSPGIVKPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1H3</accession>
    <name>A0AA38L1H3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794645">
        <property type="protein sequence ID" value="KAJ3779557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1H3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="344" mass="39219" checksum="08488D6F340843E4" modified="2024-01-24" version="1" fragment="single">MEQIESLPSITPRHFAPNKRFDFSKEAQYDGRLLHHADIPRPRALSRGKVEVRARKARDRAQRMLGFFDDEVLEFQSPHTFSYFAARRLEYLGARNSRSYPDFIAGIKAERIKRFSNSSPNPFSIRIFTDDNQKILSAFQYRAPDNMIRSNRLLVAEGRRPDVTEQPGRSALGGKGQHHLIPENLRLQYLHAAQGLLSVLPPEKAESSRRHGAVDGSYQRSHYFTHRGWDGKQDLTPERKGTLHIVPCWTQQGHPFHTMTPSAAFTANGCATAALENFYSQGVELHVWLDAIMEHEFPTQYPGFKKAHEAGRWYESDPGPHLGRVIVWKLGSEDHLDDADAIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2D8</accession>
    <name>A0AA38L2D8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_365442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793520">
        <property type="protein sequence ID" value="KAJ3781837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2D8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="102"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="288" mass="32639" checksum="C07362784934A02E" modified="2024-01-24" version="1">MATTDIKGEYQPPPGYLGNLSSEQQSALDQLKKELKGQKETEFALEGEDTFVESRMGDAGLLRFLRARKFNVAASKAMWLANEKWRKEFGVDEIVKSFDYHEKADVDKYYPQFYHKVDKDGRPLYIERLGTLDIDALYSVTTPERQLKRLVYEYEKSMTERLPACSALVGHPVSTYCTILDLKDVSIRSFYRVKDYVMSAASIGQDHYPETMGKFYIINAPFLFTGVWSVVKPWLDEVTVAKIQVLGAKNKDVLLAQIPEENLPKSLGGSCQCSEGCSLSDAGPWNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2F1</accession>
    <name>A0AA38L2F1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_370065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793996">
        <property type="protein sequence ID" value="KAJ3779995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2F1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="235" mass="25569" checksum="95A73F1BE9D7D331" modified="2024-01-24" version="1">MSADINCYHFRSLFRMFIIPIFVVANLIRLSSAWNATFLPLGDSITYGYLSTDGNGYREDLLELITAGGNSVDYIGSIQAGTMADNWNDGYIGCTIDQIASSGIPALKMVPQVVLLMAGTNDINYQEDLANAPTRLMNLVDEIFSYSPNAAVIVSDIPLIVDDTLEPLVETYNSGIQVLLQERISEGQHVVHVTLSDLTSSEMADDLHPNDEGYQVLAQAWDVGIQTASAAGWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3F4</accession>
    <name>A0AA38L3F4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_390542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793546">
        <property type="protein sequence ID" value="KAJ3781555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3F4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="22505" checksum="5343FC19307F3C03" modified="2024-01-24" version="1">MSQTAQSTSTETDHLILSDRNEKTNSLLCLGLSETLPKDTPSPAQRTSSLETKTTSVHSSKRYWDHGAEQRQFEPHHPLNNQRGCWDNKYTGSQLILLNTTSGYSQSLSTRSGVDSLINLSSLESEFQRNTDFNDDSTERIKIKAQEESSSSETMQAEPHTWGYPSDNTESLARSARAIENTLILAATYLDSYEATKPTTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3X2</accession>
    <name>A0AA38L3X2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter transmembrane region 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_363918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793477">
        <property type="protein sequence ID" value="KAJ3782425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3X2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="562"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="839" mass="93143" checksum="E3CC5CB121E82333" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4Y1</accession>
    <name>A0AA38L4Y1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_271689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793380">
        <property type="protein sequence ID" value="KAJ3784345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4Y1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="535" mass="59485" checksum="347089FFD159E10B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5F1</accession>
    <name>A0AA38L5F1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_151396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5F1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="564" mass="61891" checksum="1D42A6DC7B9A92A0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5S4</accession>
    <name>A0AA38L5S4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_393699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5S4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF109">
        <property type="entry name" value="PEPTIDASE, FAMILY S28, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="499" mass="55462" checksum="C699B8B80EBCC4E2" modified="2024-01-24" version="1">MPLDHFLNSSVDGVTTFKNRFWINTTFYDPGGPVFIFDSGEQNAAPLVPYYLQEYHGLSATMRLAKRYGGLAILWEHRYYGDSLPFPIDKNTTAEQWQFLTTEQALQDVVFFADSFSKNSSSLPVHPSMTPWVWLGGSYPGVRGALLRQRNPETIFAAWASSAPVHAQVDMWAYYAAAQRSLTVNCSADWVAVTSYVDNVLRGTNTTLIEDLKFDLLKARLSGPGGNTSGADGLTKEQANKTSAVDVASILMDPLNFYQYYGFSASILPFCNLLETRNFTSNSAENGIVSLSGVDETFQAFLVALAELDYDSIAGSPDDPVADMSWMRQYCSEYGFYQRGNPDNPLSIETSFQSLELFQQQCNEAFSDHLPSWPQVENINKYGGWDMRPSNIMFANGEFDPWRTMGLASIEPNSPQRKPSVVVPGCNVPSNATTFFGITYDNMVHVSDMRTLLVPDSNHTDFKTVGFYSPVSQAPFYTGLGLFQLALDEWLPCFAANSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L634</accession>
    <name>A0AA38L634_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxy-acyl-CoA-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_351702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793313">
        <property type="protein sequence ID" value="KAJ3786490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L634"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="58"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="341" mass="37197" checksum="17DB4460DD5C27A0" modified="2024-01-24" version="1">MVPTHICSCSRCCKHHGLFLYHHYDVLLFCYISKYSHRVASYFSDITASFDTMKISNRTFVVSGGSSGLGLATVRDLLQGNAYVAVLDLSSVPSDLIADEGSSNNIQKRRLLYIKMDVTQEDQVESAVDRVVEWSKSTGAHLGGVINGAGIAAAELTINRRGQPHSTRTWDRVLAVNLTGTFHLTRLVAKHLVTVPREYQLLQTEGAAGESKGAEGMEESDGERGVIVMIASTVAYEGQAGQIAYAASKGAIRSMTLPMARDMSRYGVRVVSIAPGPFKTPMTGQFSQSMTSRLEKEAVLFPKRYGTPEEFAATVRWILECAYVNGETLKLTGGTRVPTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L697</accession>
    <name>A0AA38L697_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L697"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041465985" evidence="1">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="180" mass="18781" checksum="CF28A1BBB6C7F0AE" modified="2024-01-24" version="1">MTRLTPLLATLLLLTGSSVNAASVADIASTKNTYPDVIPGPGLPTLAELNLTSEALYTMTPNFQTRSKPEFSGRSELYTNECFTYTTANVDDVIACFNYLESIGGNTCGIANTNVQFCYAGTAQISGSSIDGPSAASLCSDVALGVQWIFTYCNINGQVGGAAAANGNGNLIVGVENIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6E2</accession>
    <name>A0AA38L6E2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-rhamnoate dehydratase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_151069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6E2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="415" mass="46572" checksum="F8AF91F091C486F2" modified="2024-01-24" version="1">MTKAFPTIDKIETFIVSQLGDGGDYHRQKQGHWIIDSPISNPMSGYEQYRHSRTSWGIGVLGSLVVTVTASDGTKGFSTGFGGPPACWLIREHFTRFVLGSDPRDTNRIWDQMFRASMFYGRKGITLAAISVVDLAIWDLLGKLRDEPVYKMIGGRTKDKIPFYCTGPLPTETRRMGFWGAKVPLPYSPLDGFDSMRRNLDFLKAHREKVGPDYPIMVDCWMSLNVQYAIEIAKRAIDEGININWWEEVLHPDDFDGHKLLKEALPQVKWTTGEHEYSRYGFRKLIENRAIDILQPDVMWMGGLTELLKISAMASAYDIPVIPHGSGPYSYHFVMSQAHSPFCEYIANSPDGKSILPVFGNLFVNEPVPHGGSLDVSDEPGFGLTLNPQLTLLPSEQFLAPNPEKGLGKPGEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBH2</accession>
    <name>A0AA38NBH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_413223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793611">
        <property type="protein sequence ID" value="KAJ3781051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="569" mass="60891" checksum="8E8F1F92226FE53C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCJ2</accession>
    <name>A0AA38NCJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_402206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793385">
        <property type="protein sequence ID" value="KAJ3784231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="269" mass="30864" checksum="94A1C8C8C28041C9" modified="2024-01-24" version="1">MAFEDNERLDSIEILALNASRTFLCTGVEESTQNLASIMITMSSLLWIRCQWTTKNTRSGLGWDCTGNHTLRKSRRKNDSNLNEQLDVLTIHEKAVHAETERLEKLGAAERRSRRQEKENQRLELSRSEYHNRWKLLLSNTSADMPQAEIRFDDIPWPILPAFKKNEISTFLFTSCVPLADPSIDTAIGETISLSSSTSAQRLAEVEMAKARKDRKEKLRETLLCFHPDKFEGRLMSRVRPDEKVKVTEALAIIVRVLNDLMGRSGRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCX1</accession>
    <name>A0AA38NCX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rad1/Rec1/Rad17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_313109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="365" mass="40224" checksum="9941FB8CDB5F25DD" modified="2024-01-24" version="1">MSRAHDLPVLKASIHDIRYFSALLRGVNFANRATVTVTEKGLLVVVEESRTLLGTAYIFSDVFDEFIYHAETENQASQQGQTTDQEIFSAFEIPLNNFLELLNIFGTAGGSTSSKTGRYKAWKKAADDSDEHESEGGEGEGDREGGNTNKKKAGPLFGGAERKTGMRLTYIGPGYPLTVIVAEDASGPTTTCEIATFDAEDHLELPFDSEQMALKIILKSSWLRDALSELDPSCDKLTFIGNPSENLDTGAQTARQRQRARLQATPNFRIEATGTFGNTEMDYPNDRDVLESFECLAPVSFSYRFSHITRTMRAMQTSVKTSLRIDNEGLLSLQFLMPSSAPRMNSGGGTSNFIEFRCLALEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHI6</accession>
    <name>A0AA38NHI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CAMK/CAMK1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_134342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793658">
        <property type="protein sequence ID" value="KAJ3780767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHI6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="578" mass="62920" checksum="62A2E7228E908B47" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI41</accession>
    <name>A0AA38NI41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_317806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="MU793448">
        <property type="protein sequence ID" value="KAJ3782867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI41"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="162"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="519" mass="58328" checksum="0F2210A714677A5A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIV5</accession>
    <name>A0AA38NIV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794318">
        <property type="protein sequence ID" value="KAJ3779719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIV5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="267" mass="29821" checksum="EDA6F2575BB1805C" modified="2024-01-24" version="1">MSITATQSAPVAQLLENSVSLLRRTLGVQSLVKVKYKLRFCRDGTLREFGKFNAVPTAEDVSKFFSPAVEGGTNNKAVTNLAGPDDYKGHPKNKLFVKVLSFKGIDAYDKARALEMMGLLVDTGLVQVKDCKGTSTSPFPAIIMKKKEGVLLRESQEYQAANEAEQIRMEIETVTLLCEQAAKDAVQYKVYHELVLLPIQVNLTLTIKNFSDNKLENAFVTFEKGSVKAVDIFDYGHPNTYEVMKEVDEQKLSELCKAYWVRKYSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIW8</accession>
    <name>A0AA38NIW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794209">
        <property type="protein sequence ID" value="KAJ3779794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29600" checksum="90385DF59901B085" modified="2024-01-24" version="1">MEQSILLLIQRALVQQQPQTQSAPAPPTAPANPSPFVGPLSSNTAAGASSLLSLFPEVEAATITSIINHEFRASDLYKLDSRYRDKTERQILSLKGETLELTTNDAAYREYKSLNAIAVPLSTYFSILLTHAEAAGKVSLIASHFFKYNAHLIKITSEYEWSADVGYHMAFFNKRRREMQNGDYFGWGKVDMELRGEHLYNAPRLSFPSNPSSKSSRKNPPSTPNKSEPCRKFNQGLCLTTPCPFGRPHVCKKCKLTIADGSHKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJK1</accession>
    <name>A0AA38NJK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_368190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793623">
        <property type="protein sequence ID" value="KAJ3780949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJK1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="188" mass="20190" checksum="F11D3943A326D7E3" modified="2024-01-24" version="1">MRWRLPCPSSFGPSNCFSSASSSSCTVGISASGSSMSATRAREPSSSSRTPSHDSFPSDITCSTRASIGTSQESSKSPVAVNIGSSVSSSSSSSSSCFALADEVIFFQCLVTGSGAVSSQVSFSYSIGWVVLSVERALRVDGFVREYWERSYSPTRHSWNDLRMFVSLVKYESQPSARLQSVFTSVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL58</accession>
    <name>A0AA38NL58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793387">
        <property type="protein sequence ID" value="KAJ3784188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL58"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="187" mass="21592" checksum="F4A2C89274789F7D" modified="2024-01-24" version="1">MRLEEERIAELRRFEEELVIEEKWVAEEKWKEIEKVAELKAREDKRAADAAEDAEEEREQSAAYVKLVKENQKEREKAAKELERRQKRAPAAKTQTVDVVVPSRPSSSRSKVFKSKSVISDDSDVIDVDKEQVETPRGVKRKRPIKMIAKKGNVPAPIGDFDAEEEDYEEEEEKEVPSPSQRRPACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLA9</accession>
    <name>A0AA38NLA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily multidrug-resistance, DHA1 sub-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_428766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLA9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="480" mass="51815" checksum="01E7BDF8B7069273" modified="2024-01-24" version="1">MSSSTASIIQPRTPLPKLQLSLILLIQVTEPITAEVIYPFIIGAVRNTGITCGDEKKTGYYAGVIESMFFLSECGTVYYWGRLSDIYGRRTILLIGPLGLTLAMLGFGLSKTFLALVIFRALQGIFNGNIGVAKTVMAEITDSTNMADAFTMIPIMWSFGTTVGPALGGILANPATQWPQLFGKFAFFRDFPYFLACAAAGFLAFIAFALAYIGLKESSPTFKSQEMKNVTSSDESEPLLQDDETQSNYGSSTSSTGQIIGEHAQPLSAWELLTGDLRIVLLNYSLLSFTDMSYTVLIPLVYSSSISIGGLGLSPYQVGSILGIFAFLNGFWNLFVLTRILKKLGPRKMYIISYSSYLVIFPFLWIIRDVAHLAGGVNAVVWILLVCQLLAATFINTAYNSMSLLVVQSAPPNALGSVIGLAQMTASGTRGLAPLFASSLFSLSLESRIAGGHLVDIVLIVISALGLFCSFQIPKHGSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLL9</accession>
    <name>A0AA38NLL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_425855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLL9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="370" mass="40374" checksum="89081934256B474F" modified="2024-01-24" version="1">MLDAFKLKPYDLEPVYASWPDAPMFYGSLPNDGKHPKKAKDMPVDEWLRVIKEGCVERNVPKEYWHKVAQHYMGDKAKGRLDELKAVMAKVHGGNYRWNWEKFKIAMRNMGWNVDASETESIKVQGKPSGLWWMPHHSSKKDEPQCESPTEETSANPLHDAADAASEKGGNSFWITRRPTFDSLDKKEKPEKDSSESNPPQRKRPQRSATSGSTLSLQWPVRRGSKDQFEIKPDPMAVSAPRPSPQKAASDSLLTATRSMTSPIIIPGQSSDETITTVTHAPIWLLNACNALDFLSTEHPKVMSSLSAILITAGTIPSIPAISAGAGGALLASGAVQAVGAIALGVGSWLKAAHQESQARNGAGTSGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM86</accession>
    <name>A0AA38NM86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_352522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM86"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="369"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="694" mass="77559" checksum="9FBE591ECD3F8806" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN17</accession>
    <name>A0AA38NN17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_127298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN17"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="236" mass="24715" checksum="FC16C03270FBD8D6" modified="2024-01-24" version="1">MIAGLSKAVTLYLAPILSLTAILLSLFAFLAPVVMLNDRVSLLTVSPSTALTQTNGPSVDGASVFLGALGSCSRADNDAVVNCTSPSLSPVYDLSVLPSNAPQLTLTAPPSSSPAFIAVSLAFSILFFITFTMISLRHKMGAKLGAAFEKPVIQRFSAWIGFFGFFIGLTAFLILRMLMGKSVDDFNNGIVSLGSGGPQLVASSGNGFTMIWVAYAFYAVPVIASMAKLNVTQTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNK0</accession>
    <name>A0AA38NNK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_344914</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNK0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3788898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="85" mass="9632" checksum="9B613CAA4BDA2888" modified="2024-01-24" version="1">MPVPWEALIPFGLVTVMFGISGTLLNVSTKAQNLGKPIRHNIDNWDEMMMRRDEQLTGHRRGQRDDPVPPPGFETSSVWQTEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP78</accession>
    <name>A0AA38NP78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_51675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793417">
        <property type="protein sequence ID" value="KAJ3783470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="34078" checksum="F8456EA3058841DD" modified="2024-01-24" version="1">MPLELISLNDGNKIPAIAYGTGSKMKYHDITQYIEQAIEMGFSHIDTAVFYQTEKYVGKAIKESGLARSELFITTKYPREVPIQKSIKESLANLGLQYLDLYLIHQPQFIPDLVEAWKEFEKVQQDGLVKSIGISNVLNVQQLEHLIKVSKVTPAVNQIELHPYNYHKMKSIMDTCSKHNIVVEAYSSLAPITTYPGGPVDAPLRAAAHRIGATPTQVIFLWVRAKGAVIVTTTTSKAHMAEYLAVAELPALTDEEVASIDAAGAKGPPSGIVTRLRLMNTKEKLLGVVAGTMFMVYGAFGLGHLMYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPU9</accession>
    <name>A0AA38NPU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_386387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPU9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041270543" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="14541" checksum="B788CE46083A2BAD" modified="2024-01-24" version="1">MKFTITTSLLASAIAFSIAPNEVNAAPLSVLDVWDPTITSPVTGTVWVIGTEVNVTWSTDNIPPDGVSNGGHIYLAKEEDAIIPLSSNFDLVAANGSFTVTVPAVVPDNDYQIVLFGDSGNIGPSFTIVAPSSRRMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPV8</accession>
    <name>A0AA38NPV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_350327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24022" checksum="222A86459536F5FE" modified="2024-01-24" version="1">MAMFLLSYLPRAPRNGLLDEHSSEPRKTYISNPIKIDPHQQAALAAELAASELLMRQFLGGGSVQKNHNYLMEEQQRSAFVPSSPTDMQHRSRKSKALVSAQHSLPLPPTTHVIYPSAMPSMPVDTGYHTHHHHHQYAHHHGYMRSEPRRRQTSDSSSSSSSSLTPSPTSSTFDANESPSPMPYYQPQYGSDVGGHRMTAKGVNLKGRAMALFRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPY0</accession>
    <name>A0AA38NPY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_349394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPY0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041270286" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="153"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="55128" checksum="E35B798D474A382E" modified="2024-01-24" version="1">MAPSPSRLGALALMSASLLNLAAAHSHADKLDEENAATPVDSILWIHIFLQALIWGILFPTGMVLGITRSRWHVPLQSTGVALTLGGYILGHSHKGRAFLASVHGTMADILIFPILAQLILGIYLKLHIHEQTFRPWAVRLHGVVGKSYPVLGWTQMLFGAITFRGYCRGGHLGQCLAHYIMGSGFIAYGTIMAILLLSGEAWVRRSGKSPEWWDSWVIMLWGIVNTFTEHRGSNWSVKDMQHTILGVLWWAGGALGIFLARNNQRTVIPAIIIILTGWAMSEHAQALMISTRVHALFGYTLGLAGVTRIIEICFFVPTFVNHAFTAAVVVSDDSNSDHTLADAPLSPRELYASTTNNDTREVQEEKRIAGRVFRHLPPFLLVAAGILFMSATDEELEFVHENEMDHVTYILIMFSISFVLYLAIVSLISLSATSGRNVSSASSSQSHVSGYDDTTAGGIELRTPLSASAANKWYARVPSRPRDPLREQQHILGDDDDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ31</accession>
    <name>A0AA38NQ31_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_385379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3788015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ31"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="200" mass="22783" checksum="B047A63752DE9759" modified="2024-01-24" version="1">MATFSSTPIVIDGKGHLLGRLASIISKQILSGQKIVVVRCEEINISGSFFRNKLRYHNFLHKRHIVNPKKSGPFHHRAPSKILYRAIRGMTPHKTARGAAALERLKLFEGVPPPYDRKKRMVVPEALRVLRLKPGRKYCTVKRLSHEVGWGYKDVVDRLEEKRKIKAQAFHERKIAAIKLRQKAVADSSSSFPKLAELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRI3</accession>
    <name>A0AA38NRI3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin interacting protein 3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_425394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRI3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="453"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="711"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="940" mass="103509" checksum="3AE6A434B86241E6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRN5</accession>
    <name>A0AA38NRN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_342503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="392" mass="44575" checksum="D3368A24EE7B13F6" modified="2024-01-24" version="1">MYTDDSDDGSDDYVESGKAASKSRHHHRSKHKRRKTEQGVEFSTEAPHPVVSFQPLLDQVEHLPDDELFQLENSFEDVIGDSLPEYILARKDQIAKDVDRDDFGVLLRRLTRAEITSLINDRSDQVGVLSVPEAIVLRKLKLERERRRAALRGTNISATSDGVVEGLVEFTDTQLNTETVEALGNIRKTSYGSSFISRLYGNHARTPGLMHVDWDTNTPWMNLMEDIREYYQLLHPNRDPVVETRSAIMYTSLQPSHLPQVHDILSRSFWQGIDVSDSLDYSPEKCTVVASYNKMVVGVAIMSSPRETYITYLAVKHGWNSSNIATTMLYLLITLNPGKDITLHVSANNPAMLLYNRFGFKSEEFIAGFYDAYLDPESRASKNAVRLRLRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRV0</accession>
    <name>A0AA38NRV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_342275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="179"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="578" mass="64281" checksum="E6E89D6DD2EF757A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRV8</accession>
    <name>A0AA38NRV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_10357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="307"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3789992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="362" mass="41761" checksum="FA6FCEEA48C79E21" modified="2024-01-24" version="1">MAEQSTHRLDLRVGGKYRLGKKIGSGSFGDIYLGINIISGEEVAIKLESVKAKHPQLEYESKVYKGLAGGVGVPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFTLKTVLLLADQLISRIEYIHSRNFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKFRDPKTHLHIPYRENKNLTGTARYTSINTHLGVEQARRDDLESLAYVLMYFLRGALPWQGLKAATKKQKYDRIMEKKMTTPTDLLCRGFPNEFGIFLNYTRALRFDDKPDYSYLRKLFRDLFVREGYQYDYVFDWSVQRTQEEGSNGKVAAGRRKVVQEDDEHRQSDRMLRSHTRQAQQATPGAVGQQRGTRGREPELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS41</accession>
    <name>A0AA38NS41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_341744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS41"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="82287" checksum="07E57901CAE161D1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSH6</accession>
    <name>A0AA38NSH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_431113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSH6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024293">
        <property type="entry name" value="SAC3_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12209">
        <property type="entry name" value="SAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAC3 helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3790336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="320" mass="33886" checksum="EED628EED2BD47FD" modified="2024-01-24" version="1">MAPSKAERAEREQIMSTLSNRLFCDFLDDFIMDIALEAHAEVFRSRALCETCGTRCNAAHPPSSLSQPSRTQASSSRAETPSAAEGGANTPNSAKGSDGTIHLECVNCQRMVASNRYAPHLSNCMGLNSSRRGAVRGSTKAKQPSDAGRSGSPASEAGYLSDDGKAQKGKGKSRTKRADEAEFNLKRKRPISPQVSPSKKTKQKGSPVSRVKSEMDGISSSTSSLPTTNSQSKIPSKLRDSSLASFNDRESSGSSRESSPDASLSSTLSSSFMNKGIASRPKPVPLKQPSPPRPPPPVPAYIEDEEGDETGSSTDTSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NST2</accession>
    <name>A0AA38NST2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_430893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NST2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="3">
        <location>
            <begin position="536"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="661" mass="74260" checksum="4CDD2B52719BA183" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSY6</accession>
    <name>A0AA38NSY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_371173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="131" mass="14599" checksum="41197A5A784C3CAA" modified="2024-01-24" version="1">MLSAALSARLFTYSRFPRLRCSPLSRKICSSSPRQASEPPLPSPEELYSRLSHTTLAKKLQSSPEAMRAIRDFMIVLQNQGLDISSGKAPSTMQMMKLGMMKEVRDGMMKMTAEMQKAGIDPTDKARPSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSY7</accession>
    <name>A0AA38NSY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clasp N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_340459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="365"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1318" mass="141732" checksum="1B7ECEBF7934D9C2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT11</accession>
    <name>A0AA38NT11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_371174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="82" mass="9188" checksum="9D20CE39B2CE3F24" modified="2024-01-24" version="1">MAKSKKFVARSTFLICPAELTLHLFSHTNHNQNKKAHKNGIKKPKSNRTRSLKGVDAKFRRNARFALAGSQKARLEQKAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTX1</accession>
    <name>A0AA38NTX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_338552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3791058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="602" mass="68258" checksum="9E7333F688BB41E2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TY83</accession>
    <name>A0AA38TY83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_343334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TY83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="26"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="369"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="582" mass="66048" checksum="94E5D5E8BC9C2DE9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZW1</accession>
    <name>A0AA38TZW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_425140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZW1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473:SF1">
        <property type="entry name" value="DINB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="21563" checksum="FEF5DC7DB0849F43" modified="2024-01-24" version="1">MTVQLDENATNVKDLLFVSQTVLQQAVDLLDNDLKEDEQLVVTSKFLPGSTIGKHLRHARDHFELLINCITSPPPYVLNYDVRSRNTPMETSRGAARSALLETIQRLQDVVPTSNWNAPITLNAVTPFPQTFQTTFARELWFGALHCVHHWSMVRVIAGEMNMKVGDDCFGFAPSTLVASGREHSLGKTMAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1J2</accession>
    <name>A0AA38U1J2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_65571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1J2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3791099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="845" mass="96832" checksum="96844322F73945D4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U614</accession>
    <name>A0AA38U614_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_342337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3"/>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U614"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF33">
        <property type="entry name" value="ALPHA-GALACTOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="7">
        <location>
            <begin position="382"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="484" mass="53299" checksum="FF456C93B78E08F8" modified="2024-01-24" version="1">MPFLPTAVPVQVPFSPGLPPPLHSLTISTTANGFSAPARGWNSFGLQANPALNPEFVFNQTGIIQQCDHLASTLGGYGFTYCSLDSGWSHPYHGDKHGRIVPDSKLFNMTELADHLHAQGLHLGIYVVPGGFRADRHKTILDTDIRIGDVCSGDNGLARCNWNYTMDGVQQWHNSVVNQFAEWGVDFIKLDFITPGSPDNGVHLPLNTSDDVIAYHKAINNASRPMRLDISWKLARDEKHFHIWSKNADSFRTDQDINERGSNSTLAAWATVQRAIDNYRQYIVIHTGKDETLALFPDMDNLYVGNSFGEDRDGLSKARRFTIMNHWMGAASNLMLGNDLTNLDAIGIQILTNTFALSVAEFASTYPMRPRNPGTGFAYAKQLQTWVGGPDTTGKVMVLLANYGPDQGQGGFDTSMTGIQTVSASWSDLGIRNEAYRVQDVWMGEDVGIETQALEARLGEGESWLVMMTPVRSSSKWRAGGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K965</accession>
    <name>A0AA38K965_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_403965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K965"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="82"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="156"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="370" mass="41566" checksum="C74ACCAA9DFC32CC" modified="2024-01-24" version="1">MHDHINSYNPQMRSYPQMKLVYSAMIQENTSRDEPFAPPIIIINQDDTDATATTTTPPWEFYYTNEMLLGRSVPPPSRLNLTGCDCLGGQCHLNKSQCTCYLKQESFTAGYGVTGFMYHAVDQTLKSNGLPVFECNSLCACGEQCTNRVVSRGRKIPIALQKTRRKGWGVFARSSIPKGTFIGIYSGELLGHEESEERALKYDEFGRTYLFDIDWWYINQQHSKNNTNTNTSRKPCKYTVDAYHAGNFTRFLNHSCDPNSALTPVYIDMDDIERPLLTVFSKRPIQAGEEITFSYSGDPDFDDDEEEERGEEGEGEGGEGDGEGGEGEKEEGGDGDGDKASDQRTVLREVRQLEEKVEAMPLAHNPETMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9T3</accession>
    <name>A0AA38K9T3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_356711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793362">
        <property type="protein sequence ID" value="KAJ3784839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9T3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="326"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="38226" checksum="E6988BFC5AC63DF6" modified="2024-01-24" version="1">MSDEAAASNEIQINVKGPNELKLQLSISTDKTVAELKEAIAGPAKVEADRQRLIYSGRVLKDEDLLSVYKIQSSHTIHMVKGAARSGANSSSTAASSTPAAQPLPSMQTGQNVHDPLTTLNSHLGFGAMAGLNPFADMGLNPNDPNMLQTMMNSPEFLQQMSSMMSNPAIMDQIIASNPQLQALGPQAREAFQSEQFRSLLSNPESLQMMLRMSSMMQGAGMGGGMGGGMGGGMGGGLFGSAPSFPAPGTPGGASATGTTPSTNVNATSGTGTTPGSPNTGAGAANPFGMFGNPAMMQQMQQMLGGGGLGGMGGFGAPTTPADSRPPEERFQVQLQQLNDMGFTNATQNVRALLATGGNVHSAIEYILGGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBL1</accession>
    <name>A0AA38KBL1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_432713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBL1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="394" mass="43605" checksum="FB4EA1652B48B988" modified="2024-01-24" version="1" fragment="single">MNDDSTSTYSYLESPTSSESSYSNTLQNRTMFPATIPDYGLGGVWASHYQQVLNQRDLGNDCHHSCEPQQPTQSQAPTDWDHGTQSYSYSQDASAQYQDCRNLPLHAPVPLPGPSPILFTSIESANYPPQPLSSQTCHTTTATDAHQQRPISESTAPPQMHTFMNTFSVRPPVQQTFPTPCELLSELGIGSDSNDASPGSMSDSSSVATPGPSNIADTSSRKRDLKIPNLRPPEPEAITSHEKKRQYLECLEQYVLYLHEQLRLIGAQPRPIERFSSYRGLSSRSIRTMLVHMENSTAKLNAKTQTEEQRFLALRDAYLRQEGGSLSDPYVAASVETGEYYSNNARFHTRPDDTSDSVIAGHPSNAFGGPNMSTESHVTHNTNASFDQVYHARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC43</accession>
    <name>A0AA38KC43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_372779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1928"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="897"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1148"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2672"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1163"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2795" mass="310512" checksum="3A6BDD0F957D85BA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD83</accession>
    <name>A0AA38KD83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_405483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65486" checksum="89470F781AF71924" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDH4</accession>
    <name>A0AA38KDH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Muskelin N-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_396285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793415">
        <property type="protein sequence ID" value="KAJ3783538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Muskelin N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="802" mass="91318" checksum="DBF888DC0373AD86" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDU2</accession>
    <name>A0AA38KDU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_358839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDU2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="149" mass="16093" checksum="7E559661577E0D95" modified="2024-01-24" version="1">MASSLVLRAFKSSKVSSAFPRSIRTFSASSSCLGHYADADFGTFKKVTSGPQSEGRLVLVDFYADWCGPCHVLSPILKSISSDPNIKSGSGLPVDVMTINTESEDGMELSQKYKIRALPTVIAFREGQNVMQFVGALPEAQVHDFLGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDZ1</accession>
    <name>A0AA38KDZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_365621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793525">
        <property type="protein sequence ID" value="KAJ3781781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="335" mass="37478" checksum="A9B7CAABC0C18FC0" modified="2024-01-24" version="1">MGRSNKSLKNALHSQQTRLKAKEKASHAVQISEQKARKLAGRPVSAGPSTGKGKRKAHASSTQKSTIPFRSTDTILLIGEGNFSFARALARPLHSETELAHLVHLPPNNITATTYDLEDDCYVKYQDARDIVASLREWGVEVLFGVDATKLEWNSTFKGRRWSKIVWNFPHAGKGINDQDRNILSNQTLILGFLRSAAKFLKLGPVPIINGRKKRTVPSEDEDRGEDEEMSDANRSIDSEMESNRGTILITLRNVPPYTLWDLPMLAKNPLPSAPGSTTPQPRYIILRSFAFHREIWDGYQHRMTKGARAHGTGKTGEGGEDRTWEFCLKDIPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE60</accession>
    <name>A0AA38KE60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_396995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793496">
        <property type="protein sequence ID" value="KAJ3782141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="631" mass="72495" checksum="5BFC6F37E72A5B48" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFE9</accession>
    <name>A0AA38KFE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_310805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="145"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="438"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="547"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="790"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="940"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110694" checksum="D9EEC22A4854F6FA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFN3</accession>
    <name>A0AA38KFN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_30199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793379">
        <property type="protein sequence ID" value="KAJ3784376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000138">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="33824" checksum="9BC0CD085F73C960" modified="2024-01-24" version="1">MSVSTKWDARYLGPVPHDTSYYAKCMLGGALACGFTHAGITPLDVAKCNMQVNPQKYVGTGASLKLLLKEEGSRGIWKGVGPTFVGYSLQGMFKYGLYEFFKDTYMNAAGEEISEKYKGAIWLAGSSSAEFFADIALCPLEMTKVKIQTSPTGTFPVPFGAALSEMNKLKVETRFPFGSLVPLWSRQIPYTMAKFFFFEKIVQMFYTHVFTNPKDSYSQTTQLGVTFASGYIAGVVCAIVSHPADSMVSLLGKTENKGKSIGTIAGEVGFATLATKGLSTRVVMIGTLTGFQWWIYDTFKATMGMGTTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGL6</accession>
    <name>A0AA38KGL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_420764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793323">
        <property type="protein sequence ID" value="KAJ3786101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="416" mass="48353" checksum="640A62F9C9B3CB58" modified="2024-01-24" version="1">MMIIRNGPLPNDPSKLQDASERPTRNVKDPETNHRLTKLPIDSKLKMNYEKQLRNVTRRERAIEGADNVSDASSYISIPEEEYEKIIKDQPYFDRVKCWLSAQTLSWLTDKRKQLRTRTREFDENPNAASAQPLKRFRANDELNEVDPTTRPFISLDQAFLNLGLHGYNISHLEGKPQILDLADIMKKMRDSRDAGTVRELELGHFEWLEAKENFYAYQVSLYAEGTDAHELIFYRKHFGFFEKHVDSVKLYDLWKDIELEMHQKHQNKRTNFDLFDYKTEWGQVKSRFDALDTTNPNTLSSPICRPRFNNPKKPKVIHGYTSRFFVGFLSDRIFCKGGGCQWLQQRYLRDAMVYGHITVAKYGNADKLSATKPGDAERAAPSKATHMRNSEREAESSEDEGMDDDYGDDSSRESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGS2</accession>
    <name>A0AA38KGS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_95029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGS2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="166" mass="19000" checksum="AACB6346F7F07DA4" modified="2024-01-24" version="1">MPENHRNIPGTMIWLHHISLLTSVSVVVMSIFDYGMLSLYMNPLTGLLTIFFHASLLILAHKRPELKGMISVEAVVFAYLLSLTWLACFVVMVYVAWKSQMKTIRIVGMNETFLTAIDNATQRLQLMCTSLEFGLLGDLAVRSTWARRYGFEDYAETEYDDCSVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH25</accession>
    <name>A0AA38KH25_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_427242</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH25"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="11">
        <location>
            <begin position="41"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="44851" checksum="15C0C16926753789" modified="2024-01-24" version="1">MSSTGQAPLKNVLVTGGAGYIGKYSILYDLSARTAELPSPGSHVVYTLLKTRQYKVISIDNHHNSLPAALTRVSELALSELKDSSPQPSAQDLDSTVIDAHDCDLTKPTSIRSIFSSYTTKGGIWGVVHIAAYKAVGESTEIPLTYYKNNVAATISLLEIMQEFGCARLVYSSSATVYGTPPEVPIPETTRRLADSPYGRTKVMCELIVEDLCESSAVLVNGSTTTNPPFQAISLRYFNPAGAHPSGRIGEDPRGRPGNLLPLLAHMAVGRVNDPVLKVFGNDYPTIDGTCVRDYLHVLDLAHGHVLALQALEEGSDLNKTVYASIPVSKGKFKAYNLGKGKGMSVLQIVEAMRKATGFDYKTEVVGRRRGDVPALIADPALARAELGFDAPHDLETMCRDLWNWQGKNPRGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH41</accession>
    <name>A0AA38KH41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_418479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH41"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="499" mass="57078" checksum="684110C220B7A544" modified="2024-01-24" version="1">MASSFTWDTQRLRAFNALINLLSLRNGRQLELKCVNQSVPFVNDSYHRIKQRFLDRFAEVISNRRGGEHVACTIMRESGDHVVIWVARNGGFSGKDISFLKEFSAEMRALAARNVDGSGASLWNLLLNYYLPRLQDYRRRLLVKVQEHRQTLNLIGNEDFKHSLKLFFDILEQPGGTNEFGRLCCQALQIQDIPLVQNLVQTEFKSGSQRQLWKSIGFLARLRRAHRTFLKVSRTPLIFRSIIVHPITKSQDEITSSHSPLTLSDTLRLLDIRPSRLNQTTIRRYVSPTCSVEKAQQIFNQRQKQSLQVHAELQIILHLARTHVPIENVFQYMGCSKRSCFLCKAFLDSFGSIETRGCHGKLYNQWSIPAIQRIELTMKERLEDTVNRMWDILLQELHKPLQTLAALPESSNGTTPASSSAASILIPERPSEKTKVQKKKFDTTHMRKINWLPRPAARPVPPILSVIDVFRRENTISSASGEAESARATLLRLISPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLQ7</accession>
    <name>A0AA38KLQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_412843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793591">
        <property type="protein sequence ID" value="KAJ3781185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39851" checksum="21BDC0CBF4687E5E" modified="2024-01-24" version="1" fragment="single">LPSSPEVLPSAAPGRPVASLSSILNIFRLETRQGAEEVVELLHGRMVRGWNDPGSRISVRFADTSEQRELRRTERVVREDDVASPARLTIAQAALLNLRGRDQYRNQHFQQTGINAPLIGASRLTNGSAPTVNQVYNDFSCNAHDLSSAAAGGYRGSASDLTSAAQLLAGLNTNGSRRGANVSPYHQTASLPNVLGQTNQDLTPAMAALLDSLRGNGTPWPGHDDRYTIPQTQLPTLRNPQPVLGDVDLNLAFAPQYQNRVGGGVAQTRSGYTPAEELILNVHAQRRKGDHIGGDSTVYRRQDLQSDDVDFNVGVRGYRTQASTMAVQQQTSSHYPPPGNLPVVVESDGDHEAEPQRQLTRYPQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM78</accession>
    <name>A0AA38KM78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_297341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793455">
        <property type="protein sequence ID" value="KAJ3782759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55300" checksum="6723844371DB3AB6" modified="2024-01-24" version="1">MHAPAALVEDRGDSEVKDVVSQLRQDFSKYVKGVMEGKTPSVAARSTHYNEIQGSDIPLLDGRFNGRAGGQTVAPPIEIYHPVFGAFSERCKDPKLEVPNDVLCDTASLLRSVSKISVQEAPRDPETRGILAKILGVSFEHVVNTDETSCEFMCVQHTPQSINAAPALFQIKGELGNGGSDPSVQASFYYARFYCNIERTPIRERSCCPAFLISLAGPWLVIMGAVLTSRVITQRLSPYEWLGCSRVLDDDQVLQVARRLYALRLSIADLKEYYQNLPSPVVQPDHIHPRFCPCIKSFSLDGENVQFVYVQPLQRDPSSVTFKAIRSDTQSPIVIKFARRYGEDAHKWMADKRLAPKLLTCESLGEKYGNLLLVVMEFVEGQTLHDAYDSTEPLPENVRYGVRKALDVLAQGDFVFGDLRRPNVMLENENEDEELEDPLEKRIRFIDFDWAGREGSDLRYPFHLASVVRKASGALENDPITRAHQDKMFENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMD9</accession>
    <name>A0AA38KMD9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_362259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793443">
        <property type="protein sequence ID" value="KAJ3782969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMD9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="222" mass="23458" checksum="94B8EA822F6E1CD0" modified="2024-01-24" version="1">MQQNKSPKHGHGHGHGHRHGHKHNDTMSVVPPDSPGTSSPLIEDGSPGSSTPLNGSSTAPDNASSMDSSSSSNSTDSSSTDSASTVSTSKSPGSKTVHTPLTAGSRRELSGEEGHEDGKMEQKKKHNGKGQMEKGGRKKKHSNTERSEREGKEGKGGPGGRKGGPGGRKQRKGGNNKRGGPESERSSGKHENKEHGESKHGGRQRHPQKDRRYPQAYGSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN12</accession>
    <name>A0AA38KN12_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_389476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793445">
        <property type="protein sequence ID" value="KAJ3782940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="522" mass="58017" checksum="1E0480954506C849" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN33</accession>
    <name>A0AA38KN33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetrapyrrole methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_429243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793442">
        <property type="protein sequence ID" value="KAJ3783000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN33"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19916">
        <property type="entry name" value="OphMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038374">
        <property type="entry name" value="omphalotin_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="417" mass="46205" checksum="D3D7E9D90B4F6868" modified="2024-01-24" version="1">METTIQNKTGSLTIVGTGIESIGQMTLQTLSYIEAADKVFYCVIDPATEAFILTKNKNCVDLYQYYDNGKSRMDTYTQMSEVMLREVRKGLNTVGVFYGHPGVFVNPSLRALAIAKSEGYKARMLPGVSAEDCLYADLCIDPSNPGCLTYEASDFLIRERPANIYSHFILFQVGCVGIADFNFSGFENSKFGVLVDRLEEEYGADHPVIHYIAAMLPHEEPVTDQFTIGELRKPEVYKRVGGVSTFYIPPKERKDINADIVRQLEFLPEGKVPDKRAQIYPPNQWEPEVPTLPAYGPNEHATIAQLDSHSPPEQYQPLATSKAMTDVMIKLALDPNALAEYKADHRAFAQSVPDLTANERTALEMGDSWAFRCAMKDMPTSLLENAKLSVEEASKQGFPWIIVTGIVGVVGSVVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNL0</accession>
    <name>A0AA38KNL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_404481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793419">
        <property type="protein sequence ID" value="KAJ3783450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNL0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="106"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="541" mass="61926" checksum="471DCC57C2D50D08" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNN8</accession>
    <name>A0AA38KNN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_358041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793379">
        <property type="protein sequence ID" value="KAJ3784379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNN8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="310" mass="35623" checksum="DAB62AF18BE00D99" modified="2024-01-24" version="1">MLPQGVRCQITSPGPCNAILVCWEAYRLHLLRQHSLTVKRIRDNDEQTGTSRTITRKEWRCAFRCAHHVHLSRKSLEQHMISHMSKVPLCCPFQTCENLRPLESVFILIDHLDSSHHEQQILSPTELEGQLRATWWSLDSQPGGSFELPPWPDSPVDYLDIMNSHPSQPPSSSPPRTPPTSSPFRQFPRLVQSSALQSPSFNSPGRRPIPRQITIESIEDSDKPEEVFEFEDLPKSQCSPDHDPDRRPPPSQLHEDWIVWQRPHSWKKEAASPFHLQNAEDFNRMPPSSMDYNVFSARVDQLKAEGILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNQ4</accession>
    <name>A0AA38KNQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_315032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793377">
        <property type="protein sequence ID" value="KAJ3784424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="361" mass="39572" checksum="06B2B5DE1CE96FDA" modified="2024-01-24" version="1" fragment="single">MSEYWVSKKKYFCKYCEIYIADDVPSRQHHENGLRHKGNRERFIRGLYKEGEKRKKDSEDEKREMARVELAAQAAYSQDIGAGRTKATSSSASASTSKKSTTKAPSKPSNPFTNYSTAASLGYIDPDVERAVAEAALHQSQGVAGEWQVVETATVPTSMTPEGDDGTLTTTALDDGPQSLKRLADQQLEDVRNFKLRRKTLGAGLGEIYDPGEIKLKPRKEVKVEEEVKVKSEPAAPEASLENEQKPKWVAVKWKRATTSDATTPASDGAQATSENTLNEAAVPPSSSENSATVKLESEDSLSRHNSPVVKTEPTPTDEILLKTESEEAKPSTLSIAEPVHSMFRKRKVASGSGSRVKRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPW0</accession>
    <name>A0AA38KPW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vps5 C terminal like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_16153</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793362">
        <property type="protein sequence ID" value="KAJ3784845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="297"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3784845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="725" mass="79974" checksum="B5A745B8766A583A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ07</accession>
    <name>A0AA38KQ07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_428196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3784995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="351" mass="39496" checksum="476ACD522F73860E" modified="2024-01-24" version="1">MSTFAKSSFNAAVYAASRPTYPKPLFQLILDYHQQGAPALPGNDSTNDTSTSTLRPRWNTAVDLGCGTGQATTELHSFKKVIGVDPSQGMVQKAREHAEEVLGDDKASQFSFVQASAEKLDFLENESVDLVISAQAAHWFDWNKQWPEIARILRPSGTVAFWTYSEFRLPKYPSLTPLITHYLQGKDPLTSLGPYWERPGRTILERHLVDVPEPKQVLGIDSEIMTDTFRVYFSGAYHETSPTISPSPNPTITLPIILRSQSTWNGLLGYFHTFSSLHHYMEKNPSDALDHEGKSIAERTWTELMEGAEKEEKERRELEGDIEQDGKDVRVKGDDELVVEWPVAMVLAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ68</accession>
    <name>A0AA38KQ68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_8232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793350">
        <property type="protein sequence ID" value="KAJ3785190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="396" mass="44156" checksum="4AD96775A3432B5D" modified="2024-01-24" version="1">MTEPELEYSPPSSSWPSFNEDGSYPDVDRHSCQLFGPTALIVQGLMGILVILSLIFKRQREKPMRPWKIWLFDISKQVVGQMFVHGVNVLISNLLSHFSSENACVSYFLNILVDTTLGVALIYLILHVLTLVFSEKLHLKGFESGIYGNPPRVKYWARQAALYVVALTTMKFLVIGLLALFPGLFKIGAWLLSWTWTDEGDAFQVIFVMGIFPIIMNILQFWLIDSIVKASSSPVALGADGDAANPENLDREPLFGVSSDDDDDNDNLRPQRDVGHHRPRSRSRNSTSSQSHSPDKSITFSDNPYESKSSGSGSRTEIVDSHSYPPSLSSSLTSTSSTSSIREANKLNKKRRPPPAPLNLSPAPIPMPTQSKPVTRPKTDEPDVVRNEWADTWHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQL4</accession>
    <name>A0AA38KQL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_166578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041469493" evidence="1">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="68"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="403" mass="43700" checksum="2B6CCCFC984F9103" modified="2024-01-24" version="1">MHYDLKFCFATFFLHSTLALHLGPSANSIRSRIRSILPLLNPRSLPSTPTLQTRSYSPSALDVNPNGTTFLWLPEDEYSGSTFFDNFSFYTGADPTHGTVNFLNATTAFSDGLAYVQDNGIVIMKGDNTTTLAEGVNRNSVRISSNKQYNTGLFILDTNQAPWGCGVWPAFWTVGGGTWPLTGEIDIIEGVHDNEHNQVTWHTGPNCTLTPEGNFTGTIVQTNGVNNTNCDGNDNDNAGCGITEWSRASYGPFFDQQGGGVFAMKWDENGIAVWSFYRAAIPQDIQAGSPNPSGWGNPVAALEAGGCDPITNFVNHSIIFDITFCGDWAGNSYATSGCPGTCSEQLMEPSNFDNATWSINSIKVYRKQLLSGQITGGASMAGLNIRWDITLILLVFAIFSVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQW3</accession>
    <name>A0AA38KQW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQW3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041200569" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="150" mass="15972" checksum="15EB050178A95B4E" modified="2024-01-24" version="1">MFRVTLIVLLLLKFSYVLALAAPRKDLNSLVAENASQPLNFTSITSSGYCGITACSSFLRPPLTDCNITTCACTDTVSKNLATCLQCGYDNSPGMILSSAEQYLTNFTSACMANGTSVQTETLVANNAGSRAEAEVYIVLCASLVLWMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRH8</accession>
    <name>A0AA38KRH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_287593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRH8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF3">
        <property type="entry name" value="CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041287414" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="44376" checksum="EAF8E427E76EE86F" modified="2024-01-24" version="1">MAALVAPSATRVLLLLELLPLITAFSWTFQSAPTQCQNLSISISGSGTPPYNVLIIPSGSTPFTNGTEVRKIISKQFSSNSVSFELAYPAESQLVAVVSDATGFGSGGASAEAEVVSSSDSSCIDASQSVSPNWFLNLDPSNQLVQCTATRIWWTQSDVSGTPSFFGIIPGGDSFVIPESNVNTTSDTGTGFSWTPNLREGTTIHIVGNDNNGNGTGGSSRLTVGQNLQNDNSCLNSNSPSSTAGTPAGGSYPTDTSGDSTGGSSSSSNTNVGAIVGGVVGGVLGLLALLLIFYFIRRRAKQNRQSNEKPVDLLQADEGDERPNRPGQPPEYYHPDPFIVPDPTVDESSASASGRPLSASERPTSRSGTPDIASTSTGTRKTGAPRTLRPVNIIQHDDAGPSEAGGNKEDEAETIELPPAYTNIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS16</accession>
    <name>A0AA38KS16_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Orm1 type endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_292730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793350">
        <property type="protein sequence ID" value="KAJ3785196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS16"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="235" mass="26046" checksum="E0A621219F42425B" modified="2024-01-24" version="1">MQSHRPTAIQPLDITPQPRSSLSTSMNSRGRSSSLLKVEHVGSSTVEDLDQNTYVNNNANWVDAKGAWLIHVVLICIGKIIIDAIPGMEPQVSWTLVNLVYLALSYLMFHWVTGIPFQSDMHGGAYDDLTLWEQIDDGAQYTPAKKWLFSVPCVLFLASTHYTNYNPWLFGVNLCALIFALLPKLPQLHRQRVRFLADDRSGASTPVTLSFPPSGASTPVNGGTPPVIITESHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSE9</accession>
    <name>A0AA38KSE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_427828</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3785706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="541" mass="61283" checksum="F1CB2ECF3FFDD794" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSG0</accession>
    <name>A0AA38KSG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF3955 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_344788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSG0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="7">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="431" mass="47806" checksum="9116E41DBF6F22BA" modified="2024-01-24" version="1">MDSAPPSPLLRSKSTARAVSSLSRTNSSHPGKKDYAIGISLLLVVVFLWTTSNYVTQDLFQDGYEKAFFVTYLNTASFTLYLLPFLVKFCLKKSTVTWSFMKAKDVRYRSAEYDPLHSEDAYVDEDNYVEGHHHERGLSESSELPPLTVRETANLAFVFCFIWFTANWTLNASLDYTSVASATILSSTSGFFTLGIGRVFKVETLTPAKIGAVFISFVGVILVALSDSSQTSTESDNLISTSIFASTRHSLGDFLAVFSAVFYSFYVILLKVRIRSESRIDMKLFFGFVGLYNIISCWPIGIILHLTGVERFELPSSNKAVGALLVNMAITWSSDYLYVLAMLKTTPLVVTIGLSLTIPLAVVGDFFLSKPAQLQVLAGALLVLVSFVVVGFDDANMEQQQRDLMDAPRDLIVDDRRGRQRLSEGVELESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSG4</accession>
    <name>A0AA38KSG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_188384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSG4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="379" mass="42805" checksum="459A720AEA804FC1" modified="2024-01-24" version="1">MNDVLENNGTQEDTELGMVVGIMYLISSQAPPYPPGSIGELSFGIIISQDHRGKGYAKEALRLILDEAFMTMNCHRIQVCLLDTYAKDRAMRLFMGMRFVHEGRRRRAFFSILEQEWKDTTCLAILDTEWLIRSKYLIESPPATLWDELLSRHNQEREELLRWEEAQSQSWPAMLKRTSSTETVRANQYLSDTSDDTFESAVSSDADSSYEESLDLSNKLTTQPLNKGKGRVKRSIISPDFRAPFNPFFSDSEESDEFSTSKKPRFHYLSSHEDFNHDDPSGSLPKPVSSLPLPHPPSGAASSSFVAGFVTERSRDSSLSEWEDEINASADDPDGYASSTPSSHWSDLLEPRELASPTYSYPEMSDSPSESSEDDYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSN1</accession>
    <name>A0AA38KSN1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794605">
        <property type="protein sequence ID" value="KAJ3779577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSN1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="119" mass="13098" checksum="AC7A1C88F27A3931" modified="2024-01-24" version="1">MVYWDLPLRSQYMMLLVKILSPVPQLTSSYTGAAAYNSTTFEPPALPDPLPSLSLDLNIQTNPSSSGLSITQSGAFMGFSVEMSVANQVLGKNSYVSHVFFWIGDFMLQRPGPFFKSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSY1</accession>
    <name>A0AA38KSY1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794105">
        <property type="protein sequence ID" value="KAJ3779877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="476"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="535" mass="61044" checksum="C386E3FAB538BD78" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT50</accession>
    <name>A0AA38KT50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_419257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT50"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF11">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="742" mass="83160" checksum="62A5B2DAB1956549" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTB4</accession>
    <name>A0AA38KTB4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor TCF25-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_306091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3789000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTB4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="811" mass="90387" checksum="4DA4911CC206CDD2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU32</accession>
    <name>A0AA38KU32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_379504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793554">
        <property type="protein sequence ID" value="KAJ3781482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU32"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25835" checksum="E83B0F5EFCF04D3E" modified="2024-01-24" version="1">MAPTPSTASSRSLLASQRKRTSKSNRALLTTLTGHLQTRSLPNPQTSSGSKHSSSRNAPKDVIDLSNNDSDADSDICSLITSPSHRTRSTSQRIASSSQNVSSIERSDSDTDIVATKQALTLEVSAILLWFGNKLDASKKKIEKYEATNTCRKCSEIMWQPCILPCGHAMCAECIYECLCKVRISRPPVLSWDWQKRVEGMARQSGIPIPERPKFVWPSPPGWTPRRNLLGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVS1</accession>
    <name>A0AA38KVS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_333729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793367">
        <property type="protein sequence ID" value="KAJ3784692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="280" mass="31169" checksum="A7BD0C52D8555C1C" modified="2024-01-24" version="1">MTTTQAAPLDGRGHATLDPEHYQHEHSSRAPNSNTLGPRQPSHMPLVVSTTSLLVSRTWGVTLQSLLDNGAIKPFEDVLVNNDKKVFDPEINDIEFGKEITEGVNNHGIWEVVSYRGQPRDDLIAKFFREAKSEEYGEVKALRMMNLLVESGKTMDPQPLRKSLLLPVIIMKKKEGITCHQLIENSCSKDSSHSQGDNNTGNGLVTIVEGSVKVELVDYGDAYMVIDKSIPEETFGSRDFIEGQEAKYCYFSIRTRLSTSGTSIPLVTPRRRFQSTIDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW50</accession>
    <name>A0AA38KW50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_5640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW50"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="110"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="315" mass="34964" checksum="D448FD33E474D685" modified="2024-01-24" version="1">MLLAHYMTSKLVFIFMLFTHSTFSFPLLHLPHALSSDPTTEVTPNFISSTLLRPALFTRAIYCGESNVTKWDCEPCRALGPDIHVIKWGGDNAAVPNYIVAHDNSTNTIVVAHRGTNTKNFLSILTDLEIKHVDLDKSIFKHPDGVTVHVGFQDTFKHTSSIILTEVKKALIEYQSHSVLITGHSQGAAIATLGAVMLHEQLDSSIKKSVVVFGLPRMGNEHWANYVDSTIGPEFHRVTDRKDPVVDLPPHLLNFFHPSGEIHIEEVDENGQATKVAACPGQENKHCSAGNSIFHAELINHRGPYFNNILFSCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWA5</accession>
    <name>A0AA38KWA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_381112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793889">
        <property type="protein sequence ID" value="KAJ3780143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="385" mass="42437" checksum="43AEBBEAA7331ECC" modified="2024-01-24" version="1">MHKRARHVPRAERSAVDDVVIDRFTTVPQWYIAEMNRQGHPVPKLFEPKPSQKKARHAATGASLYEAGPSNVASTSATTDGEVMADIPTSANGTVIERFPAVLERRVWRGRRENDSILQWADSILSSPASDRLNGMLVESIQDSPTTNTRSIRGMLAVFRLLPNNTGNGVLTDGESNLLVHLLLCELALHPSRYDGILQSMGLLPHRAFRPGPLPDYSRTSPPTVRQIAHELAIRGYSTAQLQDLALYLLWWLYGVAASMTTRWVVIQHQFIHVVNDVLAHHVFQGVPRTSIEVENYVFTDGSQSGNLDNAGRFADYSVVLTYVRPIAQQLSLPTTGQSAAPITTDDEHLGGEPPSIVDWDDSQFNAEGDPVIDYGEDDGMNIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWW9</accession>
    <name>A0AA38KWW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_351170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="136" mass="15615" checksum="128DF237D08B0A2F" modified="2024-01-24" version="1">MADSAPVTLRTRKFITNRLLARRQFVLDVLHPSRPNVSKEELSEKLAAMYKTDKKRVVTFGFRTVFGGGRSTGFALIYDDEESQKKFEPKYRLVRSGLAAKVEKPSRKLRKERKNRSKKFRGTQKIKGAEPAKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX39</accession>
    <name>A0AA38KX39_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRO1-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_265906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3786987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX39"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="3"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="831" mass="94047" checksum="856BA88E7DEE8D4D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXW5</accession>
    <name>A0AA38KXW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_389722</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="MU793464">
        <property type="protein sequence ID" value="KAJ3782618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXW5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041388638" description="beta-glucosidase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="18">
        <location>
            <begin position="110"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="17">
        <location>
            <begin position="276"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="19">
        <location>
            <begin position="678"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3782618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="897" mass="99484" checksum="AFD91AC53AD0B327" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYT4</accession>
    <name>A0AA38KYT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_315519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="10">
        <location>
            <begin position="154"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="11">
        <location>
            <begin position="316"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="664" mass="71723" checksum="B074C2564BBA446D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZC3</accession>
    <name>A0AA38KZC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_398847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793348">
        <property type="protein sequence ID" value="KAJ3785243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZC3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="513" mass="58028" checksum="AFBC8A49CB4C80D2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZV6</accession>
    <name>A0AA38KZV6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_351971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZV6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="745" mass="80572" checksum="E0412A85A1B9C3F9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L044</accession>
    <name>A0AA38L044_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Syntaxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_349421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L044"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="30722" checksum="F79E0D97D590BA7E" modified="2024-01-24" version="1">MRGSTPTLSSTPTPSQALAKLTSISTKTLSLLLERQRSSTMSNASSSNGPSNTLHLGQIQTNLESLRNGIVELEAAGGSSKAGSQSQLEAVKLLRKQYERMRGMLLADGLNVHVPSLDPPIAPVPKKPNPLSPLTSPSNASLAPLIGTPPPRNGSPSSTLPSPSPLIPDYNGPFTPYTDDPARSPSPPSPNTLLQTQKQLIDTQDIHLSALSDSISRHHTLSLQINSELDTHHGLLEELDTELDRTEGSLGRARRRLDKVGRGIKGNGSTVCIGVLILVLLVLIIAFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L047</accession>
    <name>A0AA38L047_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_331738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L047"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041274831" evidence="2">
        <location>
            <begin position="26"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24605" checksum="CB9C33C73B038CE8" modified="2024-01-24" version="1">MLSRRSLHGLFVAWLFLASFLNVMASPIGSSENPFRSRTDPQSKSTPTGKREDCKGSVGFYSEIIGNYDHDRPPTERWGVVLDCKQGYRTAASEKVEHFDARSSFPDNIIFFGIKINREKMADIGNTLTTKGQGRNEPSKYPLTVWSTLKRTYSKDLYAPEDAETHLVEWMNMDRTRHQEQYETYLREQKEGKCAGCAKSTKRQVDACALREDACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L071</accession>
    <name>A0AA38L071_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_394052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L071"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48749" checksum="7F4D05AF586E22DE" modified="2024-01-24" version="1">MSTSNYHPKMMLDIKREIASFYGPNFQTHITTAWAEIIRELAEVTESVTKKGSEYIPQVDYAELSSLSSDRLDEIRRIGTVVIKDVVDDREAIAWQESLKEFIRANPDVPGFPANNKQFFELYWTKPQVEARSHPNVLAASAWLNNLYRKTESSERAMEGVDLSTPLTYADRFRIRHPGGGWASFPPHIDGGSIERWQDPAFRSCFNDILSGHWREHDPYALNGRLEARSSLYQRANQASVFRTFQGWLAMSKTAPTQGTLKVFPDVLLSNAYIVLRPFFRPLVSVGSSEILDPKNWEYDISLADFPGIYPKDGGFAGPWPTPETHPHMMLDKTMIPVPKVMPGDAVFWHCDVVHSVEVDHTGQEDSAVMYIPAVPTTPINKAYVEKQKDCFLKSINPPDFPKGSQAFYGISRTPEDLLSPAGLHAMGLGVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0C8</accession>
    <name>A0AA38L0C8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0C8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="340" mass="37584" checksum="42ED373787850176" modified="2024-01-24" version="1">MTLLKPSNLAALLIFPSLTVLAFHFILGRSDASEFYDKLSTQCTYASSDDAPYRLPYTGIQSIDKTLCGIVVFFHASFGPDVAPFLIYFLVSAVPIMGHAYFESSRPSRLLLMAYPVVFFQIMQLISFGATFSVYWMLFILSGASRLPPSGLKTTVTKAHAQAILFGIFLGLIILTGCMIIMQDPYVTAIWQVFPIVSSVATVLHLLVRPPSRYPDSGFGIVRGFYIASFVLISSMHITLIMSKDIDELKAFMLPSIDVLQSSTSIELQSLNLLQWDATFGFLSAVLGTLWFGRNAKETFTLLAWNLLATPLVGPGAAFSASALWRESWLHEDIKTGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L251</accession>
    <name>A0AA38L251_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_299655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793561">
        <property type="protein sequence ID" value="KAJ3781417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L251"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="259" mass="28307" checksum="F721D00A56C6BB2B" modified="2024-01-24" version="1">MSSRIEMLNAGGYRSDGRRQYELRTISIDLSPQGSGADGSASLTHGLTQVNVCVFGPREAKMRSQTYHDRANVNIEVAIAAFSASERRKRGRGDKRILELSQTLKSTFEPVIQTSLYPRSQIDIYIQVLQQDGGLLQACINATTLALANAGIPLYDFVCAVTGGVHSTSPLLDLTLLEENDLPNVTVAVMPRSGKVTVVSMETRLHVDRFEEIFRLAGEAAKAIHLEMKKAVRDRTEQLVASMQSVGRPPTGVDAGDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2F6</accession>
    <name>A0AA38L2F6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_437990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793987">
        <property type="protein sequence ID" value="KAJ3780010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2F6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041449252" evidence="2">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="153" mass="16543" checksum="185D4399004C61EB" modified="2024-01-24" version="1">MVYLHSMFTAVFAVGVAPSVFAAPVTTLTTTGFIPSSESTSQAMHIAIRDSVHFPQHGTTYSGSYPDAAGQSPASNIEAAYMHNHIPVNPQYGLHQPDPASTLTAHYVPKAAQNPVRGVRRKGNHYGESRKSIKSLVESEVCDDTMSTTRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2G6</accession>
    <name>A0AA38L2G6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_321958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793955">
        <property type="protein sequence ID" value="KAJ3780055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2G6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="526" mass="58592" checksum="5160F62170E67D90" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2H3</accession>
    <name>A0AA38L2H3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-P-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_298660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793508">
        <property type="protein sequence ID" value="KAJ3781987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2H3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35540" checksum="9CF5810378E9248E" modified="2024-01-24" version="1">MKEKFDLHHDLVDLRGKIIIVTGGNRGTGLATVKHLAQAGATVYMAARNEAKAMEAIEKLNTEGLQPGNGRVRWLKLDLSDPREAKRAAEAFIEKEKRLDVLVNNAGVLSGPFEKNTDGLSTMVVVNYISPYVFTRTLIPLLTATANEVDSDVRIINLASIAHRFTPSTVRFSQIEDLNVEYRGRMMSGFLRYAHSKLLNILWTRALQKYFDAASPPIPIVAMAIHPGGVDTFSHTWPLPWFWKPIVALAISDPEHGSYTSVFAAAAKVVRDEKEKYKGAYLDNKPVGKIEVPSKAARDDELANDLRRLTEDLLRSFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2S8</accession>
    <name>A0AA38L2S8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793724">
        <property type="protein sequence ID" value="KAJ3780490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2S8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="470" mass="50997" checksum="38CD1BD95B760322" modified="2024-01-24" version="1">MSQNDNANANDLSGSRPIQFGEFNDSSNPQNALLGANATAGTPAFNNVPGPGFPGPFGDGSHPSPVNTQNAPFGAIPHAGASAFSVSTGPGFTGPSGGGSQSGFFPNTNPQFGHTPNFGSQFHGSNNYVAPGDVFISPDNPVEDYSREPDPITHSDNCTMCMGYVAHLVTASNFNEVISERDGLIQGTTAPSTNNQGHALVDQYYDLRDHGDCYKAQARADVPESKSLDKGKGREVPMVPLQHQIASVAEGVASGSAIPLSQRLSPTEGDVKSQRKAEDTRTLRPEPAQGRIEGAPTQPRVSLMTHITPHMGDKRKREEAGPPPAQRALVLYNDLHESPEEPTYSYQAYQMEHYLTDMEDDGSEPEAHPNRLKGKQRGQQNKINRESRRRMDALAAQRAWEEGRSPPPKRTKSSKNKEYDVIRGMVTRLLFQAPVSAEEVETVVKALCYDHAHRSYTSRVALRIDAVNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L332</accession>
    <name>A0AA38L332_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_378095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793444">
        <property type="protein sequence ID" value="KAJ3782947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L332"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="169"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="344" mass="37854" checksum="9C0ACBC8BCBA287B" modified="2024-01-24" version="1">MAPITNGRLIFKEIPTGYPIPGQTTAYDTSSHIDLETEPLNGSILVKTLVLSVDPYLRGKMRAPERESYTPPFFVNEVLYNYGVGKVIRSETSAFRAGDYVYGILDFAEYFIPKDITKLEVIVEREPTLPYSVYLGAAGMPGQTSYYGWKEYAKAKAGEVIFVSTAAGPVGSIVVQLAKQDGLKVIASAGTDEKVKFCKKIGADVAFNYKTTNTADVLAKEGPIDIYWDNVGGPTLETAIANTALRARIIICGYISQYNGEEDYGIKSMKNVLSNRLSINGLLVFDHQDRYKDEFYKVIPKKLASGEFIYTEDITRGLEKGGEAILEVQKGVNTAKKIIVVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3K7</accession>
    <name>A0AA38L3K7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_319664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU793521">
        <property type="protein sequence ID" value="KAJ3781825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3K7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041489943" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="395"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="527" mass="57373" checksum="8064D3F22EF7FD18" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3R2</accession>
    <name>A0AA38L3R2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_402530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793391">
        <property type="protein sequence ID" value="KAJ3784087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3R2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="145" mass="16084" checksum="AFA4588F20E36197" modified="2024-01-24" version="1" fragment="single">CYGSLSLQAAVRYFKLIKNPVNTAIIREEFKNAQAKPVTDTHFPCHYSLFLLACAFNINLKQNYIQDGPLEVASFGCWFAAIESSELPFHRNNDGLTMLDVTEHLNPSYAFVMGDETDADLGDGPCIAEDYNSSSCLLSRSCSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4G4</accession>
    <name>A0AA38L4G4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_52270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793419">
        <property type="protein sequence ID" value="KAJ3783445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4G4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041454575" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="133" mass="15140" checksum="A98C11658E7BB662" modified="2024-01-24" version="1">MFLVTIFLIWCQLAVMTAAVPLNADVILLSRGNVLSQIHERIIHVEFTHESTGEPFHEPYPSTIEPPLLHAALDQYIAIAYPFLHRNWQLRFHNAYNGSLEPPFDIFAKFSGTRLDEHCGRGAWCTGTIHVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4V1</accession>
    <name>A0AA38L4V1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_311545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4V1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041431429" evidence="5">
        <location>
            <begin position="16"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="96"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="547" mass="61134" checksum="CFABFAA525DCEEE6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L514</accession>
    <name>A0AA38L514_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_24416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793372">
        <property type="protein sequence ID" value="KAJ3784555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L514"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="306" mass="35585" checksum="B05CF8B6F002F9F0" modified="2024-01-24" version="1">MPALHCPISINRPTPEERSISTQAARESTWGMKYPPKLPPPLPGWIRVKFYSHIYKIRHEMLPDMEGDVQLSRSGWLDLRVVCRIWNLEACTPIDPMRWVPVEPTRSFWLSPIAVHVLSAQNQCIMIIEPTPLSPTTAHKRELRDASFHLYTSFFMLFHLMYSVPITIAHTSVAFVRRWWIWCGRRSRIPMWIEHAIIPLIMLLSWFARKSKQPFNGAYAKRVNKSCKKKISIVMRSDEALWMQKHKHWIALVLCLLMLMLGGFLLLDMIGEVLYKVMSALRPYSTWGRAVVTRGLRNVRAIGRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L522</accession>
    <name>A0AA38L522_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_351419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L522"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="47"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="156" mass="17588" checksum="1C823733EF6F8E97" modified="2024-01-24" version="1">MSLYFYEPSYHFDRVFDRLFESAFAQPTIDNQPSARSGDASNVVSRPVKPKMDLHEDANTNTVTATFELPGLKKEDIQIDIHDGRLTVSGESKISSERNEDGYAIRERRYGSFARALQLPRGVKDEEIKASMDNGVLTVTFPKSTKEVEPKKITIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5G5</accession>
    <name>A0AA38L5G5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_288490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5G5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
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    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
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    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
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    </dbReference>
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        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="33"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="807" mass="89503" checksum="C17F12C1B72F0E6A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5X9</accession>
    <name>A0AA38L5X9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_346843</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5X9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 20" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="38"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="207"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="480"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="586"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="693"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1067"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3788152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1219" mass="136076" checksum="B397C776C38C8B9F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6H6</accession>
    <name>A0AA38L6H6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHF5-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_308836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6H6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="110" mass="12344" checksum="2CFB050260285F40" modified="2024-01-24" version="1" fragment="single">IGRLCEKCDGKCPVCDSYVRPETLVRICDECNFGTYGGRCIICGSPGISDAYYCAECTRLEKDRDGCPKIVNLGASRTDLFYERRRLGFKKVTAYYEPTPKANVVLHETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBJ7</accession>
    <name>A0AA38NBJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_113491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793572">
        <property type="protein sequence ID" value="KAJ3781336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBJ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="243"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="479" mass="54756" checksum="9B2C7BE686AAE037" modified="2024-01-24" version="1">MIDYHYTIHHPAQMAAALSLFAATPQQIEVSRRRAGASAWGSGMTLDEYVQRDIDLQNSECGRDGRYLTWVLAPRNDPHTLDFLCSCKTFRRAGLTARRNHNSPNSDSEPLIEPVECYGIAAVFTPPENRRKGYARLMMSLLHWVLAGNNFTSSGNIKFPSDIWGTPPAPPKEFGMGTATLSALWSDVGDFYGRCGPDDVDDELSRSKNSGGWVIRGTRMTRWCPRRDANTALMHADTGSDLHSHAGEWQWLTQEEVNRLLIHDAERMKKDLRARWFEIISSNSTSSSKTKVLFTFLPSGGVEAFQRERLRRFWEKEKIVHWGVALSDPLGDLSTVRAFATWTLDLRPPAPRTLIVTRLRCGSYSEESERSENDHEIQAQILCELLQKVWEYCSEHDVEAVEVWNFPLKLREVGYRCARQWFVPSGPDGEEEFERTWHLPAFKWYGYGYGPSTINSTDSGLIVEEVEVEWVFNEKFCWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBX1</accession>
    <name>A0AA38NBX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_364284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793489">
        <property type="protein sequence ID" value="KAJ3782251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="451" mass="50569" checksum="A5C00B4CE035012A" modified="2024-01-24" version="1">MSTGDPRVQQHRPRLPKSYTDQQLAFLKSHLPEFERRTQGSIRGDAKKFALEKAADFINVFGLPNEFIHVEEAEPRFKEQIYNWFKNTVGRTRRKLEGRPRSMKKALEKGGSMNNTIDSTWSTGNVLAAPIVMPYAQASVNSATGSPTQTLVSPVQYSVLRGSSIDPMLAHRQSSLNQQSPRQHHSSLELAVNLQITTSTLRDSFSQGIDASSLASMIQTFVKFNPSATPLTPVITSLFEAITAELSFSRDPRACLRRFLDASTLFPPSIVHAGVSGPLAGPRALQMQIRKNSIWFPNPPTESTISSPSYSMSDELQRLANDRQRKKDHIQWARIHAAALELGMLNMEHSGHTDDSGYSYAMSRAFSEMTARDAVWEEDEVEWVAGIYVLRAVIRTAMQSAQRKMEEYGELLATYERRLKDIRDENRQTMVAEALMGAKEDLAQLDGVLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCL8</accession>
    <name>A0AA38NCL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidoreductase AflY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_357737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793375">
        <property type="protein sequence ID" value="KAJ3784471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCL8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="62061" checksum="BA60D2A500A237D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCQ0</accession>
    <name>A0AA38NCQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_357202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793367">
        <property type="protein sequence ID" value="KAJ3784696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCQ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="633" mass="70582" checksum="DD3B04471C6DE99A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHG2</accession>
    <name>A0AA38NHG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HSF-type DNA-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_279286</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793717">
        <property type="protein sequence ID" value="KAJ3780512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="610"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="852"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3780512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="882" mass="96475" checksum="D46739441B265FA6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHN2</accession>
    <name>A0AA38NHN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_390691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793571">
        <property type="protein sequence ID" value="KAJ3781337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHN2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF5">
        <property type="entry name" value="STI1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="69015" checksum="165978FC35323374" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI11</accession>
    <name>A0AA38NI11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_275325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793468">
        <property type="protein sequence ID" value="KAJ3782552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF5">
        <property type="entry name" value="OS03G0795500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="168" mass="18630" checksum="CFE1C4B3BC0D1004" modified="2024-01-24" version="1" fragment="single">SLLQFLDLQQLNCLNEAVEHNLKSIVSSKSLNKSGSYLESDADEQLLLNIAFNQSVRVKSLIIKSTDIAHAPKKIKLAINRPNLGFDDVAEAEEPAVAQVLELDQETVTKGNPILLRFVRFQSVNSLHIFVVSNHGDEDETKIDAIDIIGIPVETTKDLSGLRQQQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJG7</accession>
    <name>A0AA38NJG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_414644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793657">
        <property type="protein sequence ID" value="KAJ3780769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36480" checksum="957D26933821941D" modified="2024-01-24" version="1">MSVGTRSLRRLRMASLPTRSFHLATILEDFEQCDFPALNLGTESFPSTPRETLIFEPAMSSLVPSSRTRSWSTLSAEGRRVKQSNTSKADVDRECMICFHLPQRPSRTKCCGKLFCEAHLNDWLAGSSNRCPSCSAYCHPKTDVLSLASPPSPTALSPQSSPGFFRHREHLNGDKPTGRRTGQSSHSRCHSPSPSSSSNSSIDPNTDHDDEDKSVQAKTVDSSSFQSFFVKLIRHFLDDSSLGVPEVSPVDNLQTELKVKSSSHVESPNSELPPSSSGYSSPQSQELQTYSVPSPSNSEVSSDPEMTTVALVGKVIGKVLSIIALMLVFWILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK43</accession>
    <name>A0AA38NK43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_165265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK43"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46890" checksum="7BD31615BB62DEB9" modified="2024-01-24" version="1">MTFFRFFDLFQHHHNSKLDVSFHPTIPQTQLLNPILSVTEQCLPSRIPLEVIMIIMEAAYDEEDVESNRGLLRSLALVCRDWSFPAQRLLFRHVSLNSQAHYLSFASATNQSTERGRLLGDAVYSMRASLDPNQPGRLSQLNFAQAVTRCPNLHELGISLYGCVPPGDDIVGSPDSSRMRRPAPSFDEDALALLRSGPSINTLRFSNWSENRQSITQLLNVWTSLKILVISGTPPELPSPVSEPFPCALEKLRMNFQTSPSVDFLRWLLLNSGDTLRALEFEREPSTTVLHYLIHTHHAMLTSLSLPSCSRATARVLDKCTSLRNFFVEDAISFPVALKKLSPRFEHVGFGLNKETSLQTVLEAVKVNQSLQTVSVNIWNGGKLHRQLPSLKMACASRGIHLRITHDIQVFRGIVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKG1</accession>
    <name>A0AA38NKG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7223 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_274372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793440">
        <property type="protein sequence ID" value="KAJ3783033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKG1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041402794" description="DUF7223 domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="2">
        <location>
            <begin position="253"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="548" mass="56748" checksum="538D30390A6D9AD2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKR4</accession>
    <name>A0AA38NKR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_335083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793442">
        <property type="protein sequence ID" value="KAJ3782989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041256706" evidence="1">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="17469" checksum="A423AF3F91AADE63" modified="2024-01-24" version="1">MQFKAFCVMILGLVSVGRAAAVPAAVPAAVPAAVPAAVPAAVPAAVPAAVPARYKLGVSKGSVTVIFIEDIFCKFRLPDQLAGYVKAGIKRQIEEETNEICSFLIYPDPCIAPGKKIPFKIKDGQFENGYVTYEDENLSITSVLKVHLNPAIKVTPPKESTNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM18</accession>
    <name>A0AA38NM18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_353880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM18"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF43">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041316318" evidence="2">
        <location>
            <begin position="21"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="328"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="908" mass="99162" checksum="28F900BC57B6FA32" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM41</accession>
    <name>A0AA38NM41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_184914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793328">
        <property type="protein sequence ID" value="KAJ3785913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM41"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="592" mass="65886" checksum="B5F033F500084ECD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM53</accession>
    <name>A0AA38NM53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM53"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF148">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="315"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="630" mass="68533" checksum="80E5617618709072" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMG2</accession>
    <name>A0AA38NMG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_350898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="258" mass="29431" checksum="DF1A0D287CAFA118" modified="2024-01-24" version="1">MRPLTFLRYAVALYGLALEALYPFDSLPVTISDEIKESLKAQAKDVSYFSAVVSLSFLSFFFHLIVMFSLVHGAVRLAMHYRPRFRELVEKRIAEKSLKAQNKKRPGRAVLRDVLFNLLFSVLLIVNDIIFNRSADASSFKQGVLERFHDMMQDALRIISVQSATFSVMLFFAIFFVMVRAICRRLRARRTIADEESRLAPDDMVEVTMEGQKTFALEEKLVDISDGIDVIYEKMESYAAPPAVEAEATDVEEPLIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMH4</accession>
    <name>A0AA38NMH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_350589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="275" mass="31521" checksum="1486F227D02AC17B" modified="2024-01-24" version="1">MSRSSVSAMNWEAQFKSDTPTLIQSGKNGKSRTGALALDSDNEDQDITMASASEFNSARARPVSVAPELYTQDNESPLSQLTKHWMNERHAPDILPAQEELLASLLDHIRRQSEAVQLLRGEPSASEEEHIRIMLVQMEVERVKFIVRSYVRTRLFKIEKFARFIMTDATIQTRITTAERAHASRHAHLTDRHFHNSVLQSLPETQSHLDDTPIFMPPMITKPDESRPVFVHALRDCPPIRFHEDLTLEMKRGHISLMPFSFIEQLLLRGYVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN82</accession>
    <name>A0AA38NN82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_347636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN82"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041467299" evidence="1">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="142" mass="14874" checksum="20D6CE97DB33AC0A" modified="2024-01-24" version="1">MLNIFTAIIVAIALLAVTVDASPIGSKRLPTRQDGLLFTRESSNAPSSGSGHDPAEIINTAVGAAAATSKALAVTGALPKIKDATHKGVQKVKTTLNNVKDKAHTAETKVQLGGEELRNKLSFHKHEDGVNTDGVNTDDSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN87</accession>
    <name>A0AA38NN87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_245621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="368" mass="40761" checksum="AE2E425F53D85BFA" modified="2024-01-24" version="1" fragment="single">LGQGTFSSVWLAEDLSPTSLLLSERKNVKLKSSLSTTSSLMRRLRGGVSGTRPGGASASSAKEKADNSLNLTSRGVIEERERVPGQVLSRQEKMQEEERARERDRTRVSFVREVEVMKHISHPNITPLLSHLTTRTHHVLVLPYLPGGDLLGLVNDENWHNLGENTLRRIFSELCKAVGWLHGVGLVHRDIKLETNIQPALPVPPQPLIKLTDFGLSRFIDPAKPLLTTRCGSEAYAAPDESAGGYDARETDAWACGVVLYALVARRLPFGEGPGETLGAGKISGEGGDERSFSPMQRRQWLMKIARGEWHWPEVESETDPRLLTSSELRGAGLVHSIGAKRAVGKLLVRDPSRRARVKDLWNDEWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNX5</accession>
    <name>A0AA38NNX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_298824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793513">
        <property type="protein sequence ID" value="KAJ3781925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="284" mass="30507" checksum="962E71E714783E71" modified="2024-01-24" version="1">MPGRLQDRVALITGAGSGIGLESSVLFAQEGAHIVLCDINADGAKKGVEIIAKRYPNVTAIAIKCDVSKEQDIQDAVATTVEKFGRLDIMFNNAGIMHPEDDNALNTEERIWDLTMQINLKGVWWGCKYAILAMRQNPTDASKGLHTGGSIINTASFVALMGAATPQLAYTASKGAVLAMTRELAMVHAREGIRLNSLCPGPLKTPLLMDFLNTEEKRQRRMVHLPMGRFGEAIEQARAALFLASDDSSYMTGTDFTVDGGLSSAYVTATGEPILPPPVSLVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP56</accession>
    <name>A0AA38NP56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_361653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793434">
        <property type="protein sequence ID" value="KAJ3783140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP56"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="373" mass="42218" checksum="8585F4FB83B849DA" modified="2024-01-24" version="1">MLSKSVASDFQSSRSDGEYMRYLIHRSPRLLLLSFLLFFILKLLELCWPEIHLANLSTVNMFKEISTLGFSLFTFWSLYLLSPFPTACAAPTPEGLGPNIYDVTRSPEFAHANPVSNPVSNHGQAATVAAVWGQKSYRLFRSWMTDFYPAIISLDDKNKYFKDGDFTRYLGRNLADDGKGRVGRNNVGVFEYKGRSNSNNLQLVIKVLSHPSLDDGVYGEAITLDDMGLYVASGFVLCTTAHSVKDPRTGKIKTVKQNSNRPAILMKRVGGEPITETPEWKNGNKKGRNRMMADVELLVKAKVLDIWAKHGFIYMDLNMGNVHIFFNSQSRIIDAQLFDFGYPGVVAVKRGTRQAEVEELFEHCWDHFWPLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPA8</accession>
    <name>A0AA38NPA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_41128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPA8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041209683" evidence="7">
        <location>
            <begin position="33"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="17"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="477" mass="51636" checksum="E71C8B1FEFEBA5AB" modified="2024-01-24" version="1">MSSSSIIQPRTPLPKLQLFLILLIQVTEPITAEVIYPFIIGAVRNTGITCGDEKKTGYYAGVIESMFFLSECCTVYYWGRLSDIYGRRTILLIGPLGLTLAMLGFGLSKTFLALVIFRALQGIFNGNIGVSKTVMAEITDSTNMADAFTMIPIMWSFGSTVGPALGGILANPATQWPQLFGKFVFFRDFPYFLACAAAGLLAFVAFALSCIGLKESSPTFKNQKMKNVTSSDESEPLLLDDETQSNYGSSTSSGKTIGEHAQPLGVWELLTGDLWIVLLNYSLLSFTDMSYFVLIPLVYSSSISIGGLGLSPYQVGSILGIFAFLNGFWNLFVLTKILKKLGPRKMYIISYSSFLVIFPLLWILRDVAHLAGGVNVLVWILLVCQLLAAAFINTAYNSMSLLVVQIAPPNALGSVNGLAQMAASGTRGLAPLFASSLFSLSLESRIAGGHLVDIVLIVVSALGLFCSFQLPKHGFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQX3</accession>
    <name>A0AA38NQX3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_384117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="281" mass="29731" checksum="A8CAE2212E813F48" modified="2024-01-24" version="1">MSTTTTTIPASSHLIKYSPHWNLNKSDESMVTNNAGASANLTFTGSLVQVFGTLPADNQHTIQPMSSYSLDGGPPVVFDASNFGEPSEVDNFAFYQSNPGLTSGNHSLVITSIKDNANLILDKIIVISGAGSSSVPLVFPSITTTPLPPSTPSSPSPSGSTIGSTSKINVGGIVGGIIAALVMLAGLVAFFLVRRRRNQRIAKRREATPFVPAPNGPSLTPPSHGWESYNVPTPQPRYDEKERLPEISPGPLSLVRHGSMYKPRTDSDNLPPMEFGYGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQY6</accession>
    <name>A0AA38NQY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_49625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="486" mass="54193" checksum="4621966DB0B75865" modified="2024-01-24" version="1">MPRHVPVTDNFPDFAGHLLDNGRFKLIEPLGSGAYGKVYRAIDLTSPCENPEYFAVKCLLRPKPGSRQEDFQLREFALHRIVSTHSNIVGFHKVLYDRTFVYVVLDLCLGGDLFAAITERKALRQNNELIKSIFIQLLDAVHHCHENGVYHRDLKPENILCSQDGRKIYLADFGLSTQSKVSEDFGCGSSYYMSPECIGKEFKHGKYSTRHSDIWSLGVILTNMIAGRNPWRYAMTTDDCFSAFLYNRDFLRSVLPISDQANLILKRIFHLNPFNRISIPDLRREILDVDSFFMSESELRRSSDVVRAAAANYAAPPADPPNDALERPKTPVVAAESVPSKDSSYAPKDSEEVYLFARPTEGLRPLRDHPHNSLLDVLAVGSSKDVTSASISEAESAGPITPESRPVDEPLVEVPELSEEVLGGGPNVLTYKVVQAAAKTDVKNVQAPRHRAPSNTAPKPPPRRVGKQLLRRAVQRLKALSESVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRN3</accession>
    <name>A0AA38NRN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_371741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="201" mass="21585" checksum="BD9187BA279C5448" modified="2024-01-24" version="1">MSAPRTASISRKTNETNIEVSINLDCAPGAGAAQEINVSTGIGFLDHMYTALAKHGGMSLTMKCEGDLWIDDHHTADNAIALGTAFKQALGEVRGIRRYGTGFAPLDEALSRAVIDICSRPYCVTELGLKREKIGDLSTEMIPHIFYSFAIASGCTLHVDVLRGENDHHRSESAFKALALAIRQAIERTGGNDVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRQ9</accession>
    <name>A0AA38NRQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_18699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRQ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13510" checksum="96DBEE60BF3774A6" modified="2024-01-24" version="1">MFFFLPLIFGCPTKVKPDGNEQTAHFCPRCNNASVYSAKSRTWFEFFFVPLIPMKTKHIWMCGICHWTAPLGPGQWEPPIAYQNHPQSSGQGYTSSGGYQPGYQPSYNQPSHNSHPNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRT8</accession>
    <name>A0AA38NRT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_342220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="256" mass="28146" checksum="CB91958CFC5D2DFD" modified="2024-01-24" version="1">MANPRQRRKARSSSHRAISHSKHAKRNLKKMPSIRAPKVLQQAWDNQKTVRQNYAALGLVHDLNPSESGGAEVIEMDKRTTSGSAPESFIDSTGPSTAASKSSIPKGHGRIIRDAVGNVMRIVLPEEDEIEALPADGDIDMEQLEPQLDETVRKTWVSDLGGLKTRLLTEKNTTVVKELEILSTLAPARSTTLSASLTGVGSRYTSERERSYLQRLIDKHKGDVEAMARDRKLNTAQRSVGELTHALKRAGMLAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRW9</accession>
    <name>A0AA38NRW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain binding protein 11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_383674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12622">
        <property type="entry name" value="NpwBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="490" mass="52911" checksum="66D24DAE52D52C23" modified="2024-01-24" version="1">MGKNLNPADAYRKSLRKKELKKNKAERSKARDFALVKKDTRDLEDEIEKLEGLAQPSAAEKSRLSAAKAELEKINAKKEEYVKEHPEQRRLVYRPRRDKDDGKPAEELILPKKRNYFDKNGLPRHPERSIYYDKIMNPYGVAPPGMPYMERPLLPGEVDSEAEDDEDQDDDIVMPEGPPPRIDEPVDSDDDIPMPDDPSGAEGQDDADLSAASTSHPPLPPGPPPSASTTIGVNPPLPPGPPLLPATMPFPPPLSPFHMGGFPPPPPPAGFPPGSVPLLPAGFPPGNLPPPPMGFPGFSPNLPPPPPPPAGFQPLMGQPPPGFFPRRAKSSSAMQDPLSTIPHQTYQAHRANQLTGHPSLPAKPGSVGPLLASHPSSSTATVVAEPQLRDLKKEATAFVPSALKRKRGGVASASTSRVNAAPGIANENDTELSVVPGPTRPDLLSTIRNQFGPAPSKSEQPTKKPKVDILKKKDDYERFVEDIGDILKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS94</accession>
    <name>A0AA38NS94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_303637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041482963" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="26"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="543" mass="58105" checksum="A28C756B5399D89C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSE6</accession>
    <name>A0AA38NSE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_340940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="84" mass="9708" checksum="3C68F1A84483D4DA" modified="2024-01-24" version="1">MADVPKFDEATQKELATFLEKEQTQAKLHSTVHSLTTMCWDKCITSTPSTRFARGEESCLNHCVDRFLDTSIFLVKQIQDRRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSF4</accession>
    <name>A0AA38NSF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_179194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSF4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="282" mass="30978" checksum="E42369A22026D183" modified="2024-01-24" version="1">MLRTFRFTWLLPRPITRQYATVSQSLVDLGGSPAPEGAALDFTPSIPSPLDRRILEVASCSEFPSLSELVHSYLSNSRHILNSSLLYESHPSALRKVNRGPSTANSPDVLLIAHCVQDGDEHKITVASGFALEAPSQREGESLILSCAHTLEEIRRSPIMLKNDSNSSNRHSSSTSRRVDSGSFVISSEGNMYPVIDIVSSLPRSDLMIMSCKNPGVATLPVSPYPVHAGTPVLGHFVSHELPDEPGWRPWVGDSWSKWVRGTVLGYRDFAGRETQASYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTG7</accession>
    <name>A0AA38NTG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_339713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="133" mass="15927" checksum="D61D157838C9A0A8" modified="2024-01-24" version="1">MSQLNSDFEKAVKQEEAYIRLVHPTPEETPTCISLFDTYLACNAIRSQIKSFYRYGERTHCSQKLEDFKFCLGLTRMEPEERRDVWIRKRAEWWAHRRLAKSSEDVWEMREQPPTDFPKIMTEDDIRSSTTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTP3</accession>
    <name>A0AA38NTP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PINIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_102946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="148"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="340"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="674" mass="73595" checksum="4B8ABBA246713FED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTU1</accession>
    <name>A0AA38NTU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spindle assembly checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_302148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="207" mass="23544" checksum="BEB135D1ECD434F0" modified="2024-01-24" version="1">MASKQANRQAITLKGSTALVTEFFKYAVNTILFQREVYPSDDFHMVKKYGQTVLVTQDVALESYLDKILKQVQKWLLTGSVTQLVLAIISKDTRTPLERWVFDIKLVEPPAETSEPQLPKPEAEIQSEIRAILKQIISMVTYLPVINEPTVFNILTYTSESADVPAGEWIDTDPLAIEASKSQQVKMRSFSTDVHRIEAMVAYRYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU60</accession>
    <name>A0AA38NU60_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP adenylyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_66088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000846">
        <property type="entry name" value="ATP_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="197"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3791134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="338" mass="37267" checksum="E4EC084E848365B2" modified="2024-01-24" version="1">MLASEIISKIPASYESGIESGSLFYFPSTVNIHSELGVDFEIRLCPALQKKPKLPTPHFDDSTISKSLGNFDPFAPPHDPGLLVGELTSEEISGQYVVLMNKYSVVPRHFLLITKEYQSQTSPLMPDDLLQAYALLVAGKKAGKHMFAFYNCGDLSGASQPHKHLQFIEVEDEGPPIEVLARSISLPSPGKPFSIERLPWANHVFRFPSNLRSSPLDQREHILADAFISLLDLGISTVRHDPSYPAGLPSYNVILTLEHMHLIPRRFENHTLESTGDDLSVNSMGFAGMLLVKSERELEAVKTEGLGKILRSVALQSVHDIQVAGVTKDIDGEPTSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7A9</accession>
    <name>A0AA38K7A9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_254029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794734">
        <property type="protein sequence ID" value="KAJ3779514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7A9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="189" mass="22002" checksum="FAB83744E4449BAB" modified="2024-01-24" version="1" fragment="single">KWSTTRQREGLLTHCRRELMHAVWKFLLDDEFLHAYKYGVVIQCHDGVERRFFPRIFTYSADYPEKVLIATIRDKGKCPCPRCLVEKSALDRMGLFQDLRIRRTKFRQLLTGAVTRARTFIYHSGLPINGTAVDGLLKDTSSIPTINAFDNRLGDNFSVSKMLAVDLLHEIELGVWRTLWTHLIRMLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7P8</accession>
    <name>A0AA38K7P8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793700">
        <property type="protein sequence ID" value="KAJ3780564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7P8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="279" mass="31917" checksum="75EDB2B0168C4B61" modified="2024-01-24" version="1">MADATVTVNPTTTPDVQPRIRPSRIFNAADADVLIRSCDNVEFRLHKKNLEFLSGGFPPADTETDPNEIIQLTESGETLELLFQFMYPQRFPSLTDFKIGTLTALAEAAEKYEVYALIHICELHLRSFMRQHPRKILEFAARHDHLELIQEIAPIMVPYLPLSELSTMLTPHLYTPWSVYRECWLQEAITTIAHTHPHNCYENLDKMRWGTTVLPLTLHQSLLLAPFNHNAPKYWESLASQYENRACCVSMIESVKAQIGRIVNKIPPLQLPAARDAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7V3</accession>
    <name>A0AA38K7V3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_368463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793646">
        <property type="protein sequence ID" value="KAJ3780834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7V3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3780834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="204" mass="23069" checksum="011CA3C31E52E548" modified="2024-01-24" version="1">MVRKLKHHEGKLLKKVDFLNWKQDSNLRQIKVMRRYHIQNREDYQKYNTLIGHLQTLITHLSLLPPLSPFRTHLESQILSKLYDVGVLPSSSSSSSSSSSPSGTGGGAAKLSDVRKLTVSAFCRRRLGVVMCRRGGGGLGMAESVGSATRFVEQGHVRVGTEVVRDPAYLVTRRMEDFVTWVDTSKMKRTVMRYNDELDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9D7</accession>
    <name>A0AA38K9D7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_294985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9D7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="42"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3784029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="246" mass="28834" checksum="3DBD0E7F5A666D01" modified="2024-01-24" version="1">MAPVRTEKSTRTASASQSVAGPSHRKHTRPESIADPSVLPGVQKLKAAVRQTKRLLAKEKLAADVRVTSERKLKSLEADLAKAELSRKERVLSTRYHKVKFFERQKVLRKINQAKRKLSEEDSTNQPTLETELYEHRVELNYINHYPKTKKYVSLFPADVRDDMQPSDLNSMKTDQERDEIKRWIREQMTAQSLPTEPEVIQRSQYKSNQMQWDKKVKKKDKEKEKNYEVVDDAKDDFFEEDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9R2</accession>
    <name>A0AA38K9R2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRP40, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_270782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9R2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="54" mass="5973" checksum="C818C676CB6017F7" modified="2024-01-24" version="1" fragment="single">AAPENDYGAKAHADLIVTRGAGFRKEKNKKKRGSYKGGNITMESHSYKFPDTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA23</accession>
    <name>A0AA38KA23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_313155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="64300" checksum="69719238F0D4FF4B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA27</accession>
    <name>A0AA38KA27_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_6525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA27"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="343" mass="38572" checksum="F81EB65492B74896" modified="2024-01-24" version="1">MTNPVEYRKLGASGLRVSVPIVGAMSYGSPLWAPWVLDEEKSIPILKAAWDRGLNTIDTANVYSNGESEKVVAKFIEKYNIPRHQIVILTKCSGLVASDPGTRTFYNPHMQNWPQYVNQAGLSRAAIFNAVDASLGRLKTSYIDLLQIHRFDPKVPVEETMKALHDLVQSGKVRYIGASSMRCWQFARMNETAEKHGWTKFVSMQSEYSLLYREEEREMNAYCNFNGIGLIPWAPVAGGKLCRPVDVNATVRAEEAKSSPSYSPFSDADKTIIGRVEEIAKKKGWTMTQVALAWVNMKVSSPIVGMSSVERVEENVITGYVLDEKEVEYLEEPYEPKRVRGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBI8</accession>
    <name>A0AA38KBI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_380995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="MU793846">
        <property type="protein sequence ID" value="KAJ3780223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1462" mass="165076" checksum="2B231B4D06D7EA18" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCX7</accession>
    <name>A0AA38KCX7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_381516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794065">
        <property type="protein sequence ID" value="KAJ3779921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="437" mass="49264" checksum="C685BA41580E5102" modified="2024-01-24" version="1">MKSSYTQLGVLDAPTDFVHALSFSLDGRYLASATNDEVVRVYDIQRGFATIWEHKGPCPATAVMWRDHTLFVGSMDGVLICVHPTYRWMRRRRSEVIYTADEPISAMEFNTRGDHLLVCSGADVLLFQKAPTASKKWKYHDFIPRPVAFGEFNDGDFYPILATSAHFIENDKACLISYLHNGFWKVNFDTWESRSYWGPHDSYDLSDSRRYFGRIATSAKSPDSRSVVAANLCQGLDWFKIMPDRLKKMSSTHQPQPINIPLPVLFIDHGQAVIMGSTNGCALILEVKHGEKVQALKHGSDQTWVTSLAYIEPVGRSRMIATGDGNRGQRTKIILWIENSEESPSKSSRSWFVILKIIDFVFVIGHISIILIGIISAILWLWTPQWREASAALGIYFTKTTLPATPSPSLRPVVTSSPLMTKSRRYLGILEDLLELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCZ5</accession>
    <name>A0AA38KCZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_176118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793996">
        <property type="protein sequence ID" value="KAJ3779996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCZ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3779996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="401" mass="43902" checksum="CE503D6C826408AB" modified="2024-01-24" version="1">MLAEWLTTVSFVFGGCCSNAITLEQLTSQFPRAGSLITFCQFAIISIQGLRRHVEWTSYGPRLKPRRIPLMPYLIQVVLFYLVSLLNNAAFAYRIPMAVHIIFRSGGLVVSMILGWIFAGKAYTAAQVMSVSIVTLGVVFTTLSASEPSSNMMRESSTPMYLTGIGILTLALVFSGFLGLVQDYTYTTYGRQPNSAHGSDKATHAPAWQESMFYLHFLALPMFITVRKDLVSQFHALSRGPVASYTITVPPSISATIRPSLSIPPPSAILLHPKSSSFLSFTNVETSSISSLIDTDNVFLRLQLPAACFPLFLNTITQLLCAVGVHRLTTQVSSLTVTLILVVRKAVSLIFSVVVGWGRKTGHPENVNMNMMWSGAALVMLGTLGYSLATNARNSKKRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD58</accession>
    <name>A0AA38KD58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_391320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793828">
        <property type="protein sequence ID" value="KAJ3780251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD58"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="22771" checksum="3697A72F6E7FD907" modified="2024-01-24" version="1">MLDNRLGNVMELAFSSVNIEDSRRMKNLAEVSVRDSAVMKQISYLTMIFLPASFVAAIFGMNVMEINPGSYGTVLHYLAAAIPLTVLTVWVMMMQYHATKQRSRATTPSNLLSLVRVAPSSLGRRVWSAMWWPLRVLLNELAPWRSSSRNRRRRTSWLAPSPGTSLRTRATPRSTVHMDTVREPLPVARPAPSSLREEDMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD64</accession>
    <name>A0AA38KD64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_63065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793441">
        <property type="protein sequence ID" value="KAJ3783013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD64"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="567" mass="62770" checksum="0098A3620BE9A742" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDD4</accession>
    <name>A0AA38KDD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_139331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793691">
        <property type="protein sequence ID" value="KAJ3780596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041243529" evidence="1">
        <location>
            <begin position="25"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="33"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="568" mass="60222" checksum="49AFE00D34D6B1B6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDV0</accession>
    <name>A0AA38KDV0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_429926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793548">
        <property type="protein sequence ID" value="KAJ3781541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="85"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="286" mass="30458" checksum="01C011A20C06805A" modified="2024-01-24" version="1">MLMEQVTNGPPKNRAVTRISASELAGFAPYTQFARAAYCPTDVLKDWKCGEACEANSDFEVSLVGEDGDDIQICKYSPSLGAVIVAHQGTDPMQLESDLTDADILLATPSTFPGISSSVEVHSGFLNKHALTANVILAKVKSIMNSKVTNNIVAIGHSLGGALAEIDTIFFRFNIPSASISAMTYGTPRVGNHAWAALVDASDVNFKRIDNEIDPIPIVPGRFLGFEHPIGEIHILSAGNAVSCPGDDDASDADCQIESVPTIFEGNILDHLGPYEGIYIGTIFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE78</accession>
    <name>A0AA38KE78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_356535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793360">
        <property type="protein sequence ID" value="KAJ3784903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="220" mass="24748" checksum="E7042B688B8EB503" modified="2024-01-24" version="1">MAARQAIHADTWPPAPVQNYQDHSSRTAAPVHGYPATRMNSPRDPRISALETNQAMSALASVRSAPARQYSSAPYGDHRDSPFISRPVGHGGYDSMYDRSLIGYGGRQHNVDNTREFSSESNLQSRPMYDQRNLDSSANMRHRCGYCGKRFSRPSGLKIHMTTHTGEKPYVCPEEGCHRSFSVRSNMRRHVRIVHQSTMYPEGSTDSSEDGDSRDSREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFD6</accession>
    <name>A0AA38KFD6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_388690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFD6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="906"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="906"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="976"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113053" checksum="C99861E6E89BD058" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFX5</accession>
    <name>A0AA38KFX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BCS1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_309030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3787408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="417" mass="47126" checksum="74233AB1D2C45029" modified="2024-01-24" version="1">MGVTVVFGGLRKFTTVADVFLRRRLLVQVEINNKDRAYPWLLSWMARQNQINQSLKRGSGSLISKSHRLSVETTVEQHQNGSSSVSFNLVAGTGMHWLKYRGAWMQVVRERDTRSMQMMSGNPWETVTLTTLSRDRDIFPQLLAEARDLAMRGQEGKLVIQTPWGTEWRPFGLPKRKRPLHSVVLDNGIAATIENDLQSFLNRRQWYVDRGIPYRRGYLLHGPPGSGKSSYIQALAGSLNYNLCLLNLSERGLGDDKLTYLLSTVPERSFVLIEDVDAAFNKRVQTSEDGYQSSITFSGFLNALDGVASGEERIVFLTTNHIERLDPALIRPGRVDFTQYVGDATPNQARTLFERFYGTEPLETIDIGQNLHDLVKEEMKYGKYVSMAALQGLFIRNDDAQGALAACQQIFHEIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH90</accession>
    <name>A0AA38KH90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_349795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH90"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="166"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="39054" checksum="7E0469272AEA5F78" modified="2024-01-24" version="1">MVESEFHIQLQYGPMLIGVFLNMILYGVLLNQMFFYYKTYPLDSLWVRIFVAYLLMLETANTAIDMAMMYQPLIAEYGTEEAVMYFPTLFLLEPILIVLISTPIQTFFAWRIRKITQTYWISGIVVALALASSVGGFVTGVKIAKLKLFADKPELHWSALLWFITACVADLVITATLVWNLAQRKTGFAITDSVVDKIIKMTVQTGMITSICAIGDVAFFMALPHTGLNFLWDLTLSKLYTNCLMSTLNARAGLLRNSQNTSSGVQRNALDHSLPRGSRFRPIDRYAERRSIMTTPHVYELENTRTFDSSHSQSGGKTPYSLHEHQDVEIGITVTKVIETTEDPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHM5</accession>
    <name>A0AA38KHM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_432748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHM5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="155" mass="17112" checksum="DCEDBFED07431EF8" modified="2024-01-24" version="1">MNGKSKDKDDRDQKRVRLMDRKNKRPGKVNLYYPKTLTLPSEPEPHLRESSTYPNPISPKPLPDLLCTQFLSTYICPICFSPPTNATITPCGHVACGPCLFTAVKTALRRESMMMGGAMRDEGGSRCLICRALIQGWDGQGGGVVWMVVQVVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHW0</accession>
    <name>A0AA38KHW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_114673</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041378882" description="Endo-1,4-beta-xylanase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="16">
        <location>
            <begin position="32"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3788366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="283" mass="29304" checksum="3037F54A3152538B" modified="2024-01-24" version="1">MAYKSLLSLALLAVTAAALDVFDNSTEIIGKRSIPNGEGTNNGYFYSVYSDSSVTGTYTNGAGGEYTLTWGGSGDVVVGKGWNPGGPMSVEYSGTYAPNGNSYLSVYGWMTSPLVEYYITESFGTYNPSTGGTHLGTCTSDGGVYDIYTQTRTNAPSISGTATFQQYWSIRQTHRVGGTVTTGNHYACWESVGLPLGTFNYMILATEGYSSSGTSTITVGQGTGTGSSAPTGPSSTTSTPVSVPTGGSVAEWGQCGGIGYSGPTACASPFTCTVINSYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKA6</accession>
    <name>A0AA38KKA6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_370112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794035">
        <property type="protein sequence ID" value="KAJ3779954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKA6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="316" mass="33762" checksum="E848E1459F1F4EE6" modified="2024-01-24" version="1">MSFEKEKQPLLPQAAGRSRCKYVLVIHGGAGTMSRKKSTNAQLKTYHDGLRVALKAGYRVLKDSGEAMDAAVAAVAALEDNILFNAGKGAVFNVAGKNELEASIMLSKPPASHPHIPSSRRGFGLTLLTHIRNPSKLVRELYLSPSAAPHAFLSGENAENIAESLGITLVNPAYFYSQARWKEHRRGLGLPDTPYPPGTHESEGEIKQNSSLAFLEALDMYPTGTVGAVALDIRGCICVVTSTGGRTNKLVGRIGDTPVMSAGYWAEEWGTKSGWLKNTWNTITGKKIHTRMAVGISGTGDGDVGALSLRAPSAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLE0</accession>
    <name>A0AA38KLE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_300789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793675">
        <property type="protein sequence ID" value="KAJ3780675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLE0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3780675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="419" mass="46447" checksum="FA42B5839BCFDFBE" modified="2024-01-24" version="1">MTKSTNSSIPSTLKEFLYDTHDRNGVIVISVTGLVSLIAIVSLLLAKPLKSSTYIRTHLFGYLTSLLLANGMLSVATVMSFNWIVHDQVTAGPYCTVQGALRQAGNIATALWSFIIALHLFNLLFLRFSAKKYAFWLTIIGGWGVVATVVAIGSMVIENAERGPYYGINGPWCWITNAYPEEQIFLEYFLEFLSAGLSCVLFTIVLLRVRGNLLIIDGRWKFQHVRSCDSWQLAFSRDLIDTAMLRFAQSMVWFPIAYTIVLLPSGIAGFGAVSGRPVSPGVEIFTGVTYNLTGLINVLLLLTTRQLYPDMELPEFNTQRNQQATMQLMESGGVTPFTLARSLTAESYHRQRETVLALHRATSVSSYGSSGSLKGHENGSSWTDITSSLTRHDSSSSTGSWNSQTELIPKPKEVYRTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLP0</accession>
    <name>A0AA38KLP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_367719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793600">
        <property type="protein sequence ID" value="KAJ3781125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLP0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="180"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="37548" checksum="B60089E69ACE23A2" modified="2024-01-24" version="1">MSSVTITTQDVAETLGAVQIGVLFSTFLFGILFMQWVAYFTSKFNDGWTIRGLVYWIMILDITHVAISWEYLWMYTVANFGNPATLYAAHWQYDSGPIFIVLTAAPTQFFLISRTRKMLGRQHPYLANGVFVFACLLGTVQVLMGLYMSGSLLALDASGTATTEGYLKFVPISVAWESVAIATDMTVMISLVATLMYRRTGFKQTDWMLYNLILVAIECALPVTIFTIGHITGVVASPTTAMHQLFAWSQARLYSNTLFLNLNERSKLRRGQDGTSHGSMNVKEVNFLSAMERTGAGRNMSRPQVHIDVTREEHYVMESMSNKGNDNDDFKPAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLU4</accession>
    <name>A0AA38KLU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_429990</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793568">
        <property type="protein sequence ID" value="KAJ3781365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLU4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3781365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="558" mass="62423" checksum="D1F4334196972828" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMJ5</accession>
    <name>A0AA38KMJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_335662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793485">
        <property type="protein sequence ID" value="KAJ3782310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMJ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="475" mass="54238" checksum="3BE8F146B746DAFE" modified="2024-01-24" version="1">MRTRSQSFTVSSPAPIAGPSSSSGLATSQSQSTIRRRLSPPSHVPRIFFNGVTRPLNAHTIQGSTFGIYFGLDRAVLEKTRFDSLNTRPSAPSHLVLWRFIEFRSKFSSAFDADDLFVVLVVVGTRRYVIGGTYDPALKEENMSLKQFGCEQIFKGDVGVCFLGKQEPQKFLESIPRLRNVDDGIVYLRRALDSYIKNVANHVERHAALKDVVRGYNVSTLYDMQYMLYAPDILMRKTCRKNARFDEQWTWYRNQPHEFYRYVRDEKTGMVQKLYDDPHLQSNIDKTIGLPNPKKGILNHGMEAVNYTSRKATPVSFEPLEIAPKYFMDDRVLPIMEGGTYGPTKLQSTNFNSKDSQGITAWHYSQSPFDLNFPLPETPMPSKLGTIYIHRNATDGGYQVWVWLIQGDQKKWQPVDLSGPLVHHPEIPSRVLTLQTSTGNPSWVLHSTLITTQGRHVRRRRSQSRTRSKSIQRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMN5</accession>
    <name>A0AA38KMN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_408217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793473">
        <property type="protein sequence ID" value="KAJ3782475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="453"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="453"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="456"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="66387" checksum="9329FB740A42AAE0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMR7</accession>
    <name>A0AA38KMR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793976">
        <property type="protein sequence ID" value="KAJ3780021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMR7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="24528" checksum="5A905BB59D09ADB5" modified="2024-01-24" version="1">MFGVSFGGGQQRPSNFLHTNHDQSIVDEVRNTEVVKAIARRVDFLLACYFPNLHSLYTNVLQDLCKHDGNLKPNWEGCCFAAASLNFQNAVTFSHRDYLNLLFGQCAVYSAGSFNYKKGGHLILWDLRLILEFPPGCIIFFPSAMIRHSNTAIQNSETRHSLTFFSASGLFRWRHNNFMSDKDFVAGASRDERATWDEHRRNLWQTGLELLRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMW8</accession>
    <name>A0AA38KMW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_273354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793415">
        <property type="protein sequence ID" value="KAJ3783524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="277" mass="32043" checksum="4301BA6B3A77AF21" modified="2024-01-24" version="1">MAETITQPPFNGINNFRDVGRLPRLREGMVLRSGRLDDATAEDADLMVNSYRLKTVIDLRTKSEVLNRKNISRNQEKGPSCGEKRWNTVKVNLIGRKFEMNLVQQLRWWQALWFFVLMLLQRRMTAIRIIGRNVMSPKGLVGLNKDSLQFCQYGILQERDLFLLYLDPQAYPVLVHCTQGKDRSGLIIMLILFVLRIPLKFVKADYVLSNQGLDRVRASMITEVLEIGMDEKYTQAPEEIVDEVWKFLEDGGGVDMYLDELGFGQSKRQKLRSLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN39</accession>
    <name>A0AA38KN39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_295609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="MU793407">
        <property type="protein sequence ID" value="KAJ3783719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN39"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="59"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="161"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="38003" checksum="07EE0D4FBBB59340" modified="2024-01-24" version="1">MDATASTSGDPHDMTSKDYYADSYAHFGIHEEMLKDSIRTGSYRNAILHNTHLFKGKTVLDVGCGTGILSMFAAKAGASHVVGIDMSNIIDQAQKIINANGFSETITLVKGKLEESELPIKQFDIIISEWMGYFLLYESMLDTVLLARDQYLKPGGLIFPDNATMYLAAIEDQDYKEEKINFWDNVYGFDYSCIKDIALREPLVDTVDLKSVVTDPCMIKHIDLLTAKKEDLTFEVPFTLRATRNDYAHAFLAWFDISFECTHKKVKFSTGPHAQYTHWKQTVFYTPNTITISEGDTISGRLSCAPNQRNNRDLDISISYQSVQDPTMTTMAYKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNB1</accession>
    <name>A0AA38KNB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_435595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793396">
        <property type="protein sequence ID" value="KAJ3783974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNB1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="431" mass="47186" checksum="C713328EF7029381" modified="2024-01-24" version="1">MPYGGHVQMSSTPLASSSTLHADLEDHLPTRTSRPPFTPLASSDTLIHHDEPQQNKVSDPEKYHDVEALKTSNRNRADPSATLEVPYTPPDGGFKAWSTVLGASLVAFTTFGFSNGYGAFSDFYNAEYLTHFSPTLISMIGALQVFMLYIFAGVSGAVFDAIGPRYLIPSSGIIVVLSLLLLSFTQPQKIYQQFLCQFFPAVALMSHWFKMKMPYAVGCLVSGASLGGIIFPIMLNNLIPRIGFGWTIRVIALISLLCYLVAILTIYPRRPTKPLPKFTKLLDFAGFKDPLGRVSPGLIAFRVGRFNLMWMSTFLSAALIFALWYTSFAEANLVTFVVLYGIAAGPFFTLIPPCVASISPIDKVGARLGSIYAFMASACLAGTPIGGMFIRTQTEANFKHLILFSGLMAFVGAALLFASRMLRDRRMFAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNJ5</accession>
    <name>A0AA38KNJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_360933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793420">
        <property type="protein sequence ID" value="KAJ3783420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNJ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="483" mass="53172" checksum="0811029E40B3EF05" modified="2024-01-24" version="1">MVIRRRTESLSSGVRPPSSFVPTSSNYAHVSSYRSSQMEMRVYSASVKVAGKDKTHLVPVFGEGDKVSGTITLDSKAPYSGRLIVTVEGAFFYDDFSQAGGSKRRPEPRKHVFWSSSSTIQVSPSLDSFLSLSTPRTTFRDGFTATIKSIKRRPSGSSLNTATSIPATKTPTSSGFNRTYSFSFDLPHSYRSGEEIPPTFVSVGQSELDTASGARSADVACSFGVEYKISVAWEPTEAFEYPSFVTAPIYYHPDTDFQSLDASSQESNSWLEMPLRVDRPIPFRCAITLPTAVTFSRTSSIPYYVVFTTTPRNPVLAREIASDATISASLIRQVTVTEQSILPPTPPQTPSGSDESDGIRGVQLLKRVVKPLSPRASDESLEEDQKPLPRLPMHTVFKDSRLLHTSICIGFPKRPRQHSSSDHHPSLEAQSSLPDGLHKAKFNLNKDMLPSIDWQGVSVKYYIDVSVLVGSDTLRARIPIRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPQ8</accession>
    <name>A0AA38KPQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_298413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793497">
        <property type="protein sequence ID" value="KAJ3782136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="553" mass="62879" checksum="5D3DB012F521C560" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPZ7</accession>
    <name>A0AA38KPZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_77866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793469">
        <property type="protein sequence ID" value="KAJ3782541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPZ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041446170" evidence="6">
        <location>
            <begin position="18"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="321" mass="34676" checksum="76265C7061320DE5" modified="2024-01-24" version="1">MPFSTWTLLLVLSAVFALRKLAKTQSRASIVRHAEEKVLILGASSGIGREIAHQYAARGAKVCVVGRRIDKVTAVVDECKARSLTADGSLGIPADITIVEDMVRVRTVLEKKWAGIDTVIVAAGVSATRPLLEVAGVSTQQDANASEEGIQFAVNAAKVAMRNNYLGPMIAAISFIPVLKRTSKLPSILLISSLGAVIPAPTRSIYGSTKSASLLLYQALAIEHPSVRFSFVLPSSVEGDFRASAVDQSPLDNQPTQTIPKPNSTPGLRVTDVGKRCIDAVDYSEKVVFMPSTMKLGHILYLIWPWFIEKKAMQKYGFTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQY1</accession>
    <name>A0AA38KQY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_267774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="5">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="506" mass="55472" checksum="234652A5AB519C44" modified="2024-01-24" version="1">MSKRSVTEVVSTADGQAFSKVSGSGVRRVATTEDGMGEFEDAWEDEIEEDEDVVDAEGLQEDGMDLDEVMPAIEESEEPSAAPNIFIPGTHTLAEDEVLEPDESVYVMRHSTGVDWPCLSFDVLRDNLGEERQRFPHTVWIVTGTQADAAKNNEILVYKMSSLHKTQKSGEESDSDDDEEDDALDEDPIIEYRSVPHLGGVNRVRAQPLPSSEPLPPPTQPYHVASWSETGKVYIWDVRPLIESLETPGYSLVKSRSSKPVFTIDAHGQAEGFAMDWASSGASSIRLLTGDINSKIFLTTSTVSGFSVLSQPFTSHTSSVEDIQWSPAEPTVFGSCSADRTVQIWDVRSKGRKSVAGIDPAHESDVNVISWNKGTSYLLVSGGDEGVIKVWDLRNVQKKGTSSPTPIPIASFNWHNGPITSLEWHPNDSSTFAASSADNIVSLWDLAVEQDDDEMNETSDTKDIPPQLLFNHHQKDVKELHWHPQIPGAVISTGADGFDVFSTIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRD0</accession>
    <name>A0AA38KRD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Immunoreactive mannoprotein MP88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_30343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793380">
        <property type="protein sequence ID" value="KAJ3784341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRD0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041456437" description="Immunoreactive mannoprotein MP88" evidence="2">
        <location>
            <begin position="18"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="38329" checksum="A95D9D244C78BDEA" modified="2024-01-24" version="1">MLAIATASLLLASTAFAQSTTTFPEGVVATGTMGTTNPPEPTLGTSLNQTSYARLLSVNSVDDWCIFAPPESQDIADSETIEVAWCSQARNDARVIPDGTITGVSLLKTDMYVQIMGYGDLTKINIPSGDWGGELDPHGAYGSGNPIGGNVTTNMTIDGETINVAEWMLYVSYEQFCFRACTWANSTYSAAAMCWHELDEMGCEFVMPGNYNFNGTFETCEADVAYPPGWYVEGVSDGTTSFSSFAQYWTGVVDGVTYTQGDLNTPSTVQSTPSSSNCQTVATISNGIALASLGVSGAATATGSAATATGTATNSGSSSGASGVSGSSGSTTAAASSSSNAAAPGVRVFQAGMSEGITLLSMISAIAAIAVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRE5</accession>
    <name>A0AA38KRE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_29510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="84" mass="9734" checksum="80183A99AC5536D8" modified="2024-01-24" version="1">MIAVSWTLSVCVVVTAIVLKAMNVFPKYKMHVGIWLMVSCAALVFVEAVLFWIVAIFNQKERKRITYAAKWRPLNMDRSWSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRF7</accession>
    <name>A0AA38KRF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_401554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRF7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="103333" checksum="3D5051C611186545" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRS7</accession>
    <name>A0AA38KRS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_263493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRS7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="272" mass="29742" checksum="9167B068186B2118" modified="2024-01-24" version="1">MAPSSLRTSQSHPEITLPRRPPSLRPDSPVSLYSDAYSFYQLDSTSPSPNGSHFKFDSGGTSKSPQARTPNTNTPPPPMVVVDPPEESKSKAEHYLQLGIKHHEANRLHESAMCFEKSAKEGGGCGVGMLMWGLTLRHGWGCKKDEKGGFMWVRKAAEGAVADLERARMSGGTGDFEERGVVKAELVLAIYEVGQCFFHGWGVAKDQKMGVSYYKVAARLGDADAQGDLGFCLVNGKGCKKDRKEAAKWYRAAVAQGYSDVGLAWIHKEKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS07</accession>
    <name>A0AA38KS07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_288274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="306" mass="35050" checksum="BA4F75BD613760B8" modified="2024-01-24" version="1">MGRLAEMQRKLLEQMMGPEAMGVANANLVWSDEKVCRNFLCGTCPHALFTNTKMDLGACPKSHTERLKQEFLAEKEKNPNDPIFNRFQMEYESNIFAFVDECDRRIRAAHRRLEKTPEENAKTTNLMREIAEIELAIQGGTEKIETLGEQGKVDESMKEMAAIEALKSEKSDKERELQQLTDTSGASGHQKLRVCDVCGAYLSVLDSDRRLADHFGGKMHLGYHELRNMLAKFREEREKRKSAPASSAPSSGAAPAAPSGRPADHRSSRDEYRDRDRDRYDRHSSRYDGGDRHRERDRSRSPRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTV8</accession>
    <name>A0AA38KTV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_379884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793603">
        <property type="protein sequence ID" value="KAJ3781107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="344" mass="38062" checksum="8D14E390AD7E7E2E" modified="2024-01-24" version="1">MSERSSPDPFSNTPEPQLSPMSNLRALMSQRNGVRDRTEFEQDNADPAANGGQLVVIDPVLASTSPLNVMLNRVRAIKRLRVISPDSVRDFEAFENAQSPPEHLAHILLVGLENRDFLRLLTLSMDYKVPETLKTTCKDYAWVYILSPTIMQYKGKSGPDNVLVAMRQLNVNNLPPSSETGRCDVILEIIKKGMTDARHNIKEKIASSVKNEGAAHRDIAALTRACIATSKAKPTALLFIRIAFLRWQFNQYPTYITDRFWNKVDETLVSYRTEFKTAAELQAAFEAIFHSDKVKYGQPDLVLNPSVALRDVDEWLLKVSSAAGPSGISTVAPSAASAADATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU53</accession>
    <name>A0AA38KU53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_347208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU53"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12215">
        <property type="entry name" value="ChiC_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.20">
        <property type="entry name" value="Carbohydrate-binding module superfamily 5/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="Carbohydrate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041320155" description="chitinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="28"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="560" mass="57104" checksum="A9D32509B07E1F8C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUM8</accession>
    <name>A0AA38KUM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_84927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUM8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="339" mass="36755" checksum="32790AC304CC8CAA" modified="2024-01-24" version="1">MSDTSQDSVFLVHVGQVIYWNVASLIVTCIAYGFNLLAGSIAVYLFVKNGTRGVARKALLTLTLVIMLSTTWDVINRAGLYLTQIDYILMRPLSGGILAQAVAANQATVPYEYVDGWPVTINLLIGDGIVSWRAWAIYPHNILVRASLIILMLANTAVNISDVIMEDVNPSGQTHSLAMDTASVWVSLGVNAFATSIVALKMFRHRRSVRIISRKGSMTSVEKLLLFLVESGSAFCAFQVLFAIFDTLNLYQTTTTDSSIQITTLILYSIFNGFTVLYPLAVIIMVSLNSSVIEASIHMQGPSSSGLLDSPPIRTDTKVSTMQFASGPTSSATHASLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUN5</accession>
    <name>A0AA38KUN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17767" checksum="8210E6F11189D2C5" modified="2024-01-24" version="1">MPLPQKSERKIYQILVRTHKTTLFFTVPPSTTIKYLKEQVFSALNSGLSEEEGIPIIKNVEDFDLCRCRVIKGKDQKTYDVLEQTESTIKEIKLTNWEVLYIQFKDEEGQSLEIMATDPPIDDDEESKPLHSSPTIDKGKGKRRAIEDDDEYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVP0</accession>
    <name>A0AA38KVP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIGR02453 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793372">
        <property type="protein sequence ID" value="KAJ3784557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVP0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48948" checksum="8D62C799E8F56DFC" modified="2024-01-24" version="1">MATAKRRSSKSNSRTSSNTKKGSKRVSSGARNQKASTTESDDEERSRNNASHNSDSEEGKPKNATTLKRSRNRNTRKRLQAYDSDALDDDSDFNGKEVDEEDEEPMKSKRKRANGAGKQAKTPSPRKRRRKADEDDEEDSNFDLKEGQEIVGEVVQAPKTGRVPPGQISKNTFNFLERLADPECNDREWFKLHEPVYRLAEKEFKDFVDAFTEILTEIDPHVPPLPPKDVIHRIYRDIRFSNDKTPYKKNLSASFSRSGRKGIFACYHVSSKLGFLAISVIDRTDIPSPVRPGSESLLAAGTWCPGKNELATIRSNIARSSDRLRQVISDPEFVALFGEPTPTKGGSRRNIFGAEDELKVAPKGFDKDHRDIDLLKCRTFAVLHRFKDSEVLAPDFKRRLGEAVAVARPFVHCLNDLMTLQDHNNENEDDDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW01</accession>
    <name>A0AA38KW01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASST-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_399522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW01"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041458942" evidence="1">
        <location>
            <begin position="24"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="531" mass="57398" checksum="ECD9590C24494825" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW92</accession>
    <name>A0AA38KW92_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_370031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793958">
        <property type="protein sequence ID" value="KAJ3780053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW92"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="327" mass="37663" checksum="2AA5FF6D54776852" modified="2024-01-24" version="1" fragment="single">MGQYWKIINIDYQETTGHLGKLGEFFWYDSDLITSLLIAPVIPPRFQSIPPVSQARVSKVMTSRSTATLLTLPVELLRAIAEELMDDYLALICFSVTCVSMWEVTQPVRYNLLQSVLNYRSWAGSRIILLGDHARALPEGTLTDEEIEELVSNNEEEEELENDIANLGRYLNDASDYFQRASLKLIFFDDEEVSLRKNPSLYMQLMYLPPPFRYWLSFFWEQFMPKRTEGDSWVVRNFTKREFVAKSRSRHLTSVLFSLIGCSDKSLSMLGGDWLVDGAWAGDSIDITLASIHEQEHGNETDWKDITAEVKQKLEILASKESRPFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWA4</accession>
    <name>A0AA38KWA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_312460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWA4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="169" mass="18156" checksum="93A10C02367639FD" modified="2024-01-24" version="1">MSDSAPVPYPLSSEVGQPVASTSSAAAGSSSAPATTGTGSSQSRQAAEDARKDRTLAEFMLMLDDYEPLIPNEVTDYYLQKVGFECEDPRLKRLLSLAAQKFVSDIAADAFQHARIRTNAAGGRARASQPLYGGPGSLKDRTRTTLTMDDLSAALQEYGINARKPDYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWW3</accession>
    <name>A0AA38KWW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_166361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWW3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="553" mass="62279" checksum="6C71C1F92C8776D1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1M6</accession>
    <name>A0AA38L1M6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_391380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793958">
        <property type="protein sequence ID" value="KAJ3780052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1M6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="31450" checksum="1C80229EC9D3F013" modified="2024-01-24" version="1" fragment="single">MGQYWKIRNIDYEETTGDLGKLGEFFWYGHDDVISLLITPVIPPHFKSKPVLSKTSVSEVKDDSTISPPTLLTLPVELLVVIAEELMDDYLNLICFSLTCVSMWELTHPVRYRVLESELRYKSWAGCRIILLGDYAQNLPKGILTAEEIGQLTMKNEDDKDSDEDEEDLDKKMDKTLGRRLYKADFRRISLRLNISVLEGRRLRDRYSLYKELSKFDRRFRPWLSFDWNRFLPREAEGDSWMVRNFSKREFVATDANPDPKNDHDPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3Q8</accession>
    <name>A0AA38L3Q8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_276227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU793499">
        <property type="protein sequence ID" value="KAJ3782110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3Q8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="25"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="563" mass="60606" checksum="2FEF75E109DF5442" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3U6</accession>
    <name>A0AA38L3U6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_315301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="MU793383">
        <property type="protein sequence ID" value="KAJ3784282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3U6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="292"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="672"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3784282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="824" mass="91654" checksum="42504A319C4297E1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4Q4</accession>
    <name>A0AA38L4Q4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_184722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793328">
        <property type="protein sequence ID" value="KAJ3785902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4Q4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3785902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="200" mass="22500" checksum="A5202BF144AB21F5" modified="2024-01-24" version="1">MVKIYSISVILAPPSESCTVLATASDLSQYSFYQKGSVAEFMSFFSRTVVDRTPQGQRQSVQENNYTAHVYNRGGAEQLAAVIITDQDYPVRPAFSLLTKVLDEFIAKIPQSSFRNPSSISFSEIQVYVSKYQDPAQADTIMRVQQELDETKIVLHKTIESVLERGEKLENLVDRSNALSAQSKMFYKTAKKQNDCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L560</accession>
    <name>A0AA38L560_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_356820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L560"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="272"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="441" mass="47516" checksum="4AC38476713788A9" modified="2024-01-24" version="1">MTSDTEIMLAARWHPPSYDIRIEKVPVPQIEHPDDAVLKVTLAGLCGSDLHIYRGQQPITKIHVTGHEFIGEVVKLGSNYGTDPVQSTIGRPNLYTSLNVGDKVVAPFTVNCGECHVCRVGYTGRCPSGALFGSPRLDGGQAQYVRVPKAGGTLYNLSSTASWSHTLTATSDVETLLKNISDSSLLLLSDILPTGVFAATQLLAHPKMQPMLTGRAWPSSLNPPGSALDSGTGLLTPEDRILTIAIIGLGPVGVCASVALLDALSQRSLPYRIVAIDLNESRREKLKRVYEAIGVDGKSQNGKFVVQGLEEAKETVANWTRGIGCTGVLEVVGNNSALIAAYELVRPFGVITSVGVHAPKNVPFTGEDLYNKNISFDFGRCPARAMFPIAFELLVKRQDVFGQVGTESGLIDRIVSIEQASEMYRAFDQGEVGKVLFDPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L571</accession>
    <name>A0AA38L571_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_350528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L571"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="638"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="695" mass="78767" checksum="6F034A17854CD620" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6C2</accession>
    <name>A0AA38L6C2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family group 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_155722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6C2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="916"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="47"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="685"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119805" checksum="A07A40C5B6C9D6D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6G8</accession>
    <name>A0AA38L6G8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lish motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_426852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6G8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRA" evidence="1">
        <location>
            <begin position="187"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="312" mass="34433" checksum="CF52D02E9E1598AF" modified="2024-01-24" version="1">MSSLAEADMLQATPVQLVSCPFTPGRSLILDYLAHNGYSKTARAFIRDSAVRHIGVDGDEVMQPQTASGLGPSTSELMESTLKQAELRKQIRTELRCGRIFEATILLDKYFPDVLSLSNPLRFEDTLVPSSDMDFLAPNSVYPLHLVLNLRIQTFVEACRTTPLASPSDCAYDSPSASSTEVPDLIDKQTALLNSAQKLYPLVKVLPSEQDISRYKKELESVIGLLAYPVPEESPVSGYLNQERRDAVAAQIDYAILYHAKRPVISYLELYARYTSTILGILNNSGVKPPSSWIAPPSTAKHPIRNKTFSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBS7</accession>
    <name>A0AA38NBS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_409697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793511">
        <property type="protein sequence ID" value="KAJ3781951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBS7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="594" mass="65978" checksum="C23D2DC863F25CC2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCI4</accession>
    <name>A0AA38NCI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_358794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCI4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="259" mass="29180" checksum="F6AD829D101CB292" modified="2024-01-24" version="1">MGSTLSSVSSAFTKDAEDASYNGYPSEDDVSSVRDYMLEIFPIEIIDLILDFGEYWPCLRVDSNDEIEAVASSTVTGEATWLYLISPPILPKEMPGTDSRHRRVKKVQFETESHDQGWTSTPANKGTYNGSWSWFEAIIYRASASPCWLDLTSGPFNLGATFTGSDIKELFPNPNPNGWHIQSNVVASRESRVHSITWTEYEDPEVHVDPKSLKGREGLGHELVRSLEPDDRVMLIAKSKFRGWTNHTYRGSIEIFYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCQ7</accession>
    <name>A0AA38NCQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_270770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="34178" checksum="3053F5774B8072A7" modified="2024-01-24" version="1">MSPTYLTLPDGARIAYQLLGSEWSGRSEPIVFVGGVSSTGEDWQRLAQPLSMKRPVLIYDHRGIGESSYSTASKDDDITIELMARDLLLLLQFLKFSEIALCGFSMGGAVTQQLLLLPYLASDPVTLPFKVNSVFLTGTFPTMWEEKGYGLKLDRTPITGPLTDEEKKARARPNLERSFDPEWVADPANQDRFNWWLDRQIVGRWTAQVARMKLYGYEQIPKSTHFLIIHGEKDAIVPFSNAAKLLRVISQASFIQTGFEPGQIPTLAFGHHWWEYFDIEVWINVVETFLSSRENQQQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND51</accession>
    <name>A0AA38ND51_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_311818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND51"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="622"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="787" mass="88249" checksum="ED2B444F0A0EE03D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH46</accession>
    <name>A0AA38NH46_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_238426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794624">
        <property type="protein sequence ID" value="KAJ3779567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH46"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="262" mass="29525" checksum="25AB77E89AA70379" modified="2024-01-24" version="1" fragment="single">TDNLIPAARIGFKIPAEIWYKKWMDIAHLRPFGVMGWGTIVNKTPGKLDLRVFKGRLVGYGPDRGVYLLYTSSGRVVPSRDVEFEERILPTLPPAGEEGRYDGEDVFFPTDNNAKAGDAEKADEVIDDTPAEIEAKPIQIAELNSNSEIKTQPQPKIRRSTRTRNPSSKASATREFLSREDDAKNRKEAWATSGRPRANVISFAMLTTHLPDEVNSEFNIALTVFGLPIVPKSYRQSMEDPERWMPAIKKEKLRMEEFGVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHY0</accession>
    <name>A0AA38NHY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_408801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793489">
        <property type="protein sequence ID" value="KAJ3782252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHY0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="91" mass="10588" checksum="D5155A4E530EE495" modified="2024-01-24" version="1" fragment="single">MGRRKIEIQPITHERNRSVTFLKRKHGLFKKAYELGVLCSVDVAVIIFEEKPGHNFKKLYQYCSCDVQDMVQRHIRHDGEKDTRGPADFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJE1</accession>
    <name>A0AA38NJE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_434497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJE1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="58"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="291" mass="32086" checksum="607F281CF35D9271" modified="2024-01-24" version="1">MVPLPNVSHYLLGHSILGDMSNSVNYADLFGFKSIPAAVIFAICYVPLCCWFIPKVIMRRTYVVFTVTLFCFMRVSAFILRVILIASESVGENESVFITDEVLFSIGFFGLLFGAYGLVLDRLSLLTTSKAQSYPLSFLIQNRKLFHLVLTAGMIMGIIGITNSTSSTPSSSGSTLRKASVIVFVVLTILQAYQTFILVMLERSENPEALTLYLGHSIGARHGAMIFVCISVLLLVREVYMLATIGSSITQNKEYTWYPLVALPELVCVTLYALPGIIPPPPGSEIYNLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJW3</accession>
    <name>A0AA38NJW3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_386756</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJW3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
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        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="249"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="827"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3786317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="937" mass="104780" checksum="092183B0BBDF9BD5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK29</accession>
    <name>A0AA38NK29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_436987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793513">
        <property type="protein sequence ID" value="KAJ3781924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22538" checksum="A1CD33A50AD04D5D" modified="2024-01-24" version="1">MPGSTSIFDVNKQLTFYGAYHNNKINILIHVICVPLIMWSAMVLLASAPRPSFLPEYHREFNKGMVLELNYPTLLLVVYETYYLILEPVAALLYAPQFILSLLTATAFAQRADHLTVAIAMQTCSWIAQFLGHGVAEKRAPALLDNLIGAIVLAPFFVHLEILFAIGYRPDMHKRLVNDIGTEIARIKKIEGDKRRAKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL09</accession>
    <name>A0AA38NL09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_373434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL09"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="487" mass="53136" checksum="CE76B14167A763EC" modified="2024-01-24" version="1">MGVKVESYGKRKVIEGVTMRALTFYSLTATAKMPPKKAKKISLNEFLGDSPGSWADEMDQLPSAPAMRSDEDQGRQNDRYGRRGDDFLASRPDRAPLPPREDIPLPTQPPYTAFTKSVKLIKDRDDKPKGFGYVEFEDLDMLKDAISKNGAAFSGRTIRVSVAEAPKERPSYGGNDDSKFDNPWRRDGPLPDLSSSRDSSRRRFDGPRPEPLPSVSEDASDWRSNRSRAALPEPETPTGSMRKKTMGFGSDSSGAADREDVWTKGSKFKPSEEREPALPASRFGSARGRGDMGPPRDSVPEESDWRSSSRPRPVRDNTSPTGSTPPTPQMGRRKLELLPRSGSASNVPSPLSSPKIGPTPPTSGNRSNPFGAARPVDVTAKELEIAQKVEKERELNRDRISMSRTSSRTGVERPISRNNTPPASAGSHPHSPSSPPAPAAKIIPQNMSANVRPAFSFANAAANKKTEDAEMNGKEETIAEKLGEVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL50</accession>
    <name>A0AA38NL50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_393445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL50"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="540" mass="61496" checksum="EEF11F96570AE901" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLH2</accession>
    <name>A0AA38NLH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_293828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793368">
        <property type="protein sequence ID" value="KAJ3784653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="399" mass="43799" checksum="CFF51E96DE66683D" modified="2024-01-24" version="1">MIMAPTNINNGSSLPQLSLNNGVMLKMKPSRIFKTAVENPAVSPGRPSFGPRHVTGICFDDRGDQLLTAAEDETFRLYNCKSGKHLKTLQSKKYGIDLPRFTHKSTAIIHASTKEDDGIRYHSLHDNKYLSYFKGHKGRVISLEMSPVDDGFMSGSLDKTVRLWDLRAPNCRGLLTLPAPPVIAYDASGLVFAVAVNNYSRILLYDQANFDKAPFLVITLEDPTLNLISYPPRPIYMTSLSFSSNGKYLLVGCSGNAHYILDAFGGHLIAKLEGHVGLERRSITAALTIQPDKGCSGEEVSWTPDSRFIVGGSLDGKVLVWDVQDLQVPQGPVNLKAVPRQIHPLVAHDGHPGISRCVKFNPRYGMMATAGAELAFWLSDTAPESDEVARDLLKRKAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLQ8</accession>
    <name>A0AA38NLQ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_22513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793367">
        <property type="protein sequence ID" value="KAJ3784684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3784684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="529" mass="60102" checksum="744BC923E6EBC2CF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLV3</accession>
    <name>A0AA38NLV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminoadipate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_12891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3784999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLV3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="562"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120115" checksum="48D30609E01BC634" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMV4</accession>
    <name>A0AA38NMV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794283">
        <property type="protein sequence ID" value="KAJ3779735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="66" mass="7437" checksum="7958A71A9F7E009C" modified="2024-01-24" version="1" fragment="single">MTHVLGNTTPHEVLLGVKPNLSNLHPWGCRVRVHDTSGSKLDGRATEGRWVGFDEESCAHRVYWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNF9</accession>
    <name>A0AA38NNF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_368839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793671">
        <property type="protein sequence ID" value="KAJ3780695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="559" mass="62508" checksum="8FA486DB7FC6D61B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNQ4</accession>
    <name>A0AA38NNQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SVP1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_88783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="448" mass="49594" checksum="FEBAD8A0A45F04B4" modified="2024-01-24" version="1">MNLARHSITATNPVHIFDTRLDTDCEIFTTCSPAGFAVYKAWPLQLLRKRELSGGTLAAAMPMHTSSLLFLLGGGRSPLYPLNKVILWDDAIGGEVAELEFRERVRGLACRRGWLAVSLRRRVVVFEIGRQVTRYQEWDTCDNPRGLVTLASGTHATLLAIPGRQMGHVQLIHLPPCSPPPLTGPPPLTPPRKPPPPPEKYPVSIIAAHTTALSTLSVPPSGRLLATTSSRGTLVRIWDSLTGKLVRELRRGTDKAEIFGVAFRPDEQELCVWSDKGTVHLFTLLSAVSNRQSTFSPLVPYIPLPKYFESEWSYAQYRIPTQSSHISLSATTSSRSSTEDIPDEERCVVGWIKVPGEASMPSEYQLIALTYAGGWYRLSVPKANSTASASITPSLTPRSHGRSTSISSTRSERSYSNKGKEKEKSKDPNASRCKLQEFRRYGRWDGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP11</accession>
    <name>A0AA38NP11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_335517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793474">
        <property type="protein sequence ID" value="KAJ3782465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="121" mass="13561" checksum="77774212FEB26EBE" modified="2024-01-24" version="1">MSTVRPTVAAVAVAAPRPAAASLYTCKVVFCHCDPKFALLRVRYSFQLEIGEAQAMWLRMHVRVRTRIKPQKRAHPARVADVGQENIETVHEPEPIQAVDFLCMDKVAVLWRNSTAHKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPI0</accession>
    <name>A0AA38NPI0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_356132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3785000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPI0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="529"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="612" mass="68814" checksum="173B71B620FD9F0E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPM3</accession>
    <name>A0AA38NPM3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-iditol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_192352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPM3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08286">
        <property type="entry name" value="FDH_like_ADH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="2"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="36691" checksum="ABF50D83CB0153B9" modified="2024-01-24" version="1">MATMKALVYAATGKPTLEDRPKPTILKPTDAIVKMIKTTICGTDLHIFKGDVATCDTGRIIGHEGVAVVEQVGDKVSHFKPGDKVIVSCITSCTTCTNCRTGMPSHCTDGGWTLGNTIDGTQAEYTRVPHADGSLHRVAKNASDDAQLMLSDIVPTGYECGVLQGKVKLGSTVAIVGSGPVGLSALITSQLFSPLQVIMIDLNEKRLSTARSLGATHTVVSGPNAVEQVMKLTAGRGVDTVIEAVGIPATFELCQKLVAVGGTIANLGVHGAKVDLHMEKLWDRNITITTRLVSTTSTSMLIKLVESGKIQPEKVLTHNFAFGDIEKAYSIFGAAESHNCLKVVINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ38</accession>
    <name>A0AA38NQ38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_347048</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ38"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3788120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="267" mass="29425" checksum="4156E3BFACCE0BB7" modified="2024-01-24" version="1">MNPFASSAALDMQGQFSTQDTHMYSVILPTYNERKNLSIIVWLLAKMFSDNQLAWEIIIVDDASPDGTQEIAKQLAATYGEDKIILKPRAGKLGLGTAYIHGLNFVRGDFVIIMDADFSHHPKFIPQFIQQQKAHNFDIVTGTRYRSSATPSLATAKPGGVHGWDLKRKLVSRGANFLAATVLSPGVSDLTGSFRLYKLSVLQHIISVTQSKGYVFQMEMMVRAKALGYTVGEVPITFVDRLYGESKLGADEIVSYAKGVWGLFVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ77</accession>
    <name>A0AA38NQ77_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_384764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ77"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="142"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="381" mass="41685" checksum="34B632B463EB13FE" modified="2024-01-24" version="1">MASKRLVVDVHTHLYLPRYASLLRERTTLPKIITRACDDGRKEERLVILKDEPSGGRPIGPSYVERDEKLTFMKKHGIDISIVSTANPWLDFLQPKEAHQLSLQLNDDLEEYCSTGPTVTGTSMKQLYGFGLLPIVSGISTESLLEAVRQISASSHLKGLIMGTRGVGKGLDDEALDPIWAAISEAGLTVFLHPHYGISKESWGEKNNGHVLPLALGFPMETTIATTRLILSGVFDRFPSLRLLLAHSGGALPQLSSRLASCIDHDPIVASRLKHDARFYLGKLYLDAVCYGPEELGFVSDVIARSNRYETGSKNVASGGRSSGSGRMLFGTDHPFFPPLSSSERWKSVVENLDAIENVQGWTEADKNGVKGGNAISLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQD4</accession>
    <name>A0AA38NQD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_305625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="45609" checksum="F59235A947953D35" modified="2024-01-24" version="1">MSSSPTYTDEEKKQLLINLDIEVQHRTRQLRSWLEDQLEGFKIHQENTISRIPKPVRTITMREFGEKYHGNPVIAATESQKERLAAQVGDGLGEMDKTERKRKWMAIQETREVDDGESSRKSKSARLTSYVSPKKRGGTSTGPGTAQRAKLLASGEKAPGRPRIPMDRIPGSPSPQKAKAPFTTSTTYTPRAPPSPSKLPVHKPGQPRTRVPSSSTFNPTLPAKTPTYPRNTHHMHTASATLRAPRKDEQMLSINGSPLSNPFWVDGLLPPDARPGGSTGGSHTLKRTQSNISIRRDPSFVSGLPPRADSQSSFYPGTSSKPHSRNNSDATLAESTTGPFSGLPKTSFETPYVPTKKYMVTISTKDGHILEFDPLQTSPKALDALDGITDSAKKQAREEMSRLVEAAVDKWKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQD7</accession>
    <name>A0AA38NQD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_261256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="220"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="683" mass="77721" checksum="6D8D960AC9870AF0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQI1</accession>
    <name>A0AA38NQI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_406279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="208" mass="23267" checksum="9644A01D1FC55552" modified="2024-01-24" version="1">MYFRGSDTRASLSFRVCTGLFLGLVCAAFATALPLSDNDMPNPTSSVHLAARNDLKRLPMMLRFMNPGGICELLDKHKTVKQVQAYLERMQAGFGFVPTISVEDVVSIEGVPDDPCITTEDRLYLHLKLKGSTTEESKEFWDKWGSWKYGRVQIASPFSLKEAYILQGRSRSITLNDNALKIIMLLNLIQTGQPRIQLPPASISKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQX5</accession>
    <name>A0AA38NQX5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_384123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47623" checksum="EF4CA42DB738F4A8" modified="2024-01-24" version="1">MPDLSSPAIDPPTSYLPSIKSLSSFTENHRLHDCIVYLRQIYVPNVRGSRRRKPKQQNPSNISFSIPHPSPITTIRKDPFERAYALRWLSALTRLEPPPTDSSELADIQNAAAALLAICAGTASAGTVQRRCEFAGGRIQIALNDVPLSTDASNGDYFGSVGAQTWGGAFVLAEEIADNSIIFFPDTAQVDVVPEVQEPFRVLELGAGTGLVSLVAGKVAMLNYSGRQVDIIATDYYPSVLDNLKANIEANFSSSISSLNITSRFLDWSSFSSFDITPDADASLPPNNIGTFDLILGADIIYEPLHASWIRRVVENTLRKSSLSTEKNCPDRNNGGGQGLFHLVIPLRPSFVAESSTIEQEFRFVGDKNNNNNQDGSKDDLVILSREIILCDADEDDEEADIDLDGRNSVSEDTRSQVGEGNIVRYVYYIIGWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRA7</accession>
    <name>A0AA38NRA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_383878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRA7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="635" mass="71161" checksum="ACED6972F2CEFCEC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS62</accession>
    <name>A0AA38NS62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_431143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS62"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="41969" checksum="A25D6A1F65BC9CEF" modified="2024-01-24" version="1">MTASQLPSSDLVYDTTSVYTKIFIGLQLAGLIGNIVTLIIAYFSPVSRQATWYNCIIMWCLYSIAFLLLFFSGHYHDPSPPFDLCLIQSALIHAASPSATAATLALVVQLYFSVYSALNLHPIPYQSLWLKIILAFPYATGSILVALFFVLSLIDPSTTTFNITAYCAVNQIIPGRITAGLTITLVIPMMIIDGLIYARLRKHWSEFRASQLGRYTSMIIRASLFSICAFVALCAGFGFFLVVFAQNPTEPIDQVVHRLLLAYNILNIFLSIFPVAVMLIFGTHEDILRRLFFCERHEMNSVSEHAVPNMSLTISSPPLEDSIELESRIRTIDDHRFNESQSSEELSTFSKRGNPDDRSEMQGAMRKPASPWEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSC7</accession>
    <name>A0AA38NSC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_178582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="127"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="225"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="783" mass="84132" checksum="5E95573E8F9C4E11" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NST0</accession>
    <name>A0AA38NST0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_383198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NST0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="525" mass="60395" checksum="FA11776AB4360628" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTC0</accession>
    <name>A0AA38NTC0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_339409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTC0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="37993" checksum="F929F61C3AABDCE6" modified="2024-01-24" version="1">MLFPESFQKLFVTLSTTQSASDRPPVKIFALRHSPSQLSILTPSERPRKVLLLLHGYPQNHTLYYETVQELWKAGMLEHWDVVIPDLPGYGRSTKIPSMDGSHYENSKRAIAADCVALIDTMYSPGQRFIVAGHDRGARVAYRMAKDFRDRILGICLMEIIPTRMMFQKMNSMNNHQLTLNTYHWIFLAQPPTLPETLIGASSDYYFSHTIESWTGPRYRGNLDPIAVASWVEQYRNPAVLTGSLEDYRAGASIDLEHDEEDEKSGKAAVDCPLLILHTREFKAQHKDVADIWEPLGSNGVIVKQVGDDQVGHFLPIEAAADAIPELISWMNEIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTD7</accession>
    <name>A0AA38NTD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_339575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="310" mass="35138" checksum="5E406EA4AFC88EAF" modified="2024-01-24" version="1">MPVPASRLVIDLESSTGAAFCFLAWEILITLDDEVELIWSKPRHSWIKWAFLLARYGALSLLLAGRVLELIVTYSTMHLNTNSIRIWFALQGLLAFSIMAGAEIVMMARVYALYNRNKLVGYGFITLMLAEVFTALLGFGLTFPPPSFDPQLIITTTPGSFEYFSISTLVSQIVVVLLSVARYRYMYRRGHWEGTRIIKLMFRDGTLAFLVFFLLSLLMAVYHILQEPFAPSEYVWSISIISVTECRLILNLQKLPISEADTLTEFAEFTTIASNDRSRLGTSYMMTVFPGTQGTDVHELHEQPQSEMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTR0</accession>
    <name>A0AA38NTR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_104044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041275346" evidence="2">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="178" mass="20195" checksum="61F301532DE94C4B" modified="2024-01-24" version="1">MRTFLIFLYMSLLSVAYVIPPSERRHQDLGISSPQKPEKRPPSSSSVTPADRLAAIPSGLMRITISPDNPVQDVAGAVRNETIEGFIISLLHTNGYPNLRGEEVYWHNHERTEAGWTEEGNRPLEFRVEDDRTDKHCHLFCEATLDVVESVRTQRPAGRIGTPNMAWMDYLLSQVHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTZ0</accession>
    <name>A0AA38NTZ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_338757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3791109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="152" mass="17263" checksum="A62EFE204295F8D4" modified="2024-01-24" version="1">MASSEEVILNKAHHPHPNSIEAFGHVLHDIKHAIIHSRRDWDKHEPRMWSRASGISDQELVNFTLEKDLVLVRSAPVSYGTIILGKIRIPAINDDEGEGYIHVRVHDPPNRGNEDVKFHSIFTDEGNKNADGQATSWRAVQTKDTPLEFFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYX4</accession>
    <name>A0AA38TYX4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_342724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYX4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="15"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="368"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="427" mass="47631" checksum="02D982557900D08F" modified="2024-01-24" version="1">MKGFVKTVKRTPFMVTSKVGMSKKSNDPEFDDYQRHFSSMEQAVEKLLKDTKAFTDAVNSLFTAGAGFATHFSVIFHPIAGEYDLIGKHPDVAHTIKSVDKYETAMEELRSSVAPELELIESRIVGPSKEFQGVLKTIRKTITKRDHKLMDYDRFNNSLTKLRDKKEKSLSDEKNLFKLEQDFEMATNEYDYINTALKQDLPRFMTLSTQFIDPLFHSFFYMQLNVFYIILEKMNNFSEDAKYDISNISGNEITSNYESQRTDAWSEIEELNITKRIISTSKFVQSNRAAGVSRTTSSTSSLASSRSPPSSGFKKAPPPPPPFAASHTASPPPYTPSNGPASAAASAAAAKRAPPPPPPLKPKPKLAPKPQFVVALYDFIAQAEGDLSFNTGDRIEIVEKTTSAEDWWTGKLNGVQGVFPGNYVQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZZ8</accession>
    <name>A0AA38TZZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_392115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZZ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="233"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="434" mass="46000" checksum="D11046AF96215BE8" modified="2024-01-24" version="1">MNPMGMGSVAEAPRRAHLYVGNLSPRVTEFMLTEIFAVAGPVQHVKIIPDRNYQHGGLNYGFVEYIDMRAAETALQTLNGRKIFDTEIRVNWAYQGQQNKEDTTGHYHVFVGDLSPEVNDEVLAKAFSAFGTMSDARVMWDMNSGKSRGYGFLAFRDKTDAEQAIATMNGEWLGSRAIRVNWANQKTQGSPPMSSSPQRPGGASLGTAPAPINFQGGPLSYESVVQQTPAYNTTVYVGNLVPYCTQADLIPLFQSIGYLSEIRMQADRGFAFVKLDTHEHAAMAIVQLQGQMVHGRSIKCSWGKDRADGAAPAPISPTAGAAAPYGNMPMYGMPQPNTFGQYAYGGYGGFPNQAAGTPGGGAPGAGGMPQPATAGGGLGLVPGAQAPGADAAAGQAGQAQWAADPSSYYSNYWGGYYGQQAGQQPGVDTQMAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0Y0</accession>
    <name>A0AA38U0Y0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-trefoil</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_391692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0Y0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="114"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="248"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="72111" checksum="1AC7C363B5DA2DE4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U136</accession>
    <name>A0AA38U136_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_382925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U136"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="4">
        <location>
            <begin position="86"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="293" mass="32458" checksum="ADC26618CC19F228" modified="2024-01-24" version="1">MSAPHVSKPVEFGDPKLGDFCVEYPNGLVDLSRSNHLDHQKPSDIDTTEEPGAQPGSSVTTPPLRPGQLDIPVTGDKTVRLDTKKTAFVIIDMQNFFLHQDIRDHPKGLACVDPLMKVVPFFRDNNIKILWVNWGLGDDELNTIPSSLARGFNANHGNRGFGSKLRGEFGRVLIKGEKNTELYGPLQGLFEDGRDRGTDFWIYKNRMSGLWNQTPLEHLLKENGIRTLLFAGVYADDCVLGTIIDANHKGYDCILVEDTTATTSPDVTYEAVLYNTGNTYGFVTSTDKVLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U194</accession>
    <name>A0AA38U194_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_338567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U194"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="273"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3791065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="328" mass="36720" checksum="EDEE343F24AC7BA1" modified="2024-01-24" version="1">MSVNRIIHVSPVDYSGTVRCYTHELEASRRISQTEGNSNREFYCCSKDPEHRCDFFFWVDQLTAGTPHQPPPMSQTNSSTPSRTSQVPRTPSKLRLDAIEEALAEKKSDPRANGNNQFTTPSSRIRAQKVKTPGQLKRDEEIRRAVEPPSQSTQQSNDANVFQSSQPPPSNYKLTPLSQESINHSDEDDFFAALPLTPLPLTPPTTQRIKRSRDHDSDEESEPDFRNSPSKNKGKKKVTVAHDSITPTTSANDVTDTFSAPASLKLSGIIDSLEVFRGQVAKLERQIKALKKSNEAKLEKIQNLETDNHALKSENDELRGKIQALEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1G2</accession>
    <name>A0AA38U1G2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_280651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1G2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3791172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="180" mass="20205" checksum="CEA0866B4AB85674" modified="2024-01-24" version="1">MAEDVKNRYEAIKKELLAQIPKKRAIDKKLAQVEAQIFTLEGTYLSETGTHSGGNLIQGFENYLKNQTTGRRRTEAAEHDRIFSSSSLTYTRSLDLMSEENGDDDLAKQTNAGLTTVIVPPATRSEGLTAAQQNKLTRDKEYQRRKRASTRRSAGTISDDDSVPQLGRRPTKRARLMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1J3</accession>
    <name>A0AA38U1J3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_340646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1J3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="49799" checksum="7D3ED7C1521447BD" modified="2024-01-24" version="1">MKYVSFELLALSVTNWRLRRICLPFLFANIRIRHIKDARKLKDSSLVLIQRFTRLLVISHFSSRSEEGDQILCSILPYMKRLEWVELRCCSSRSVLLKAILANPTVSTLLVEQLREASLYVDPSKVVLEGTLISTTVSPDLETCLDHLGCLEAIEPDLLNDDFTQRHFSGLQELRLSLRRYYVTFSWLSVLSSTHSSLKEISLIDDKRYHHVFSRTPTSVVQGSQRQDLSKNYSIDRVVLCRTTGQYPQGWRVTGLTISAAPSNTSLVKILTLIPVSFPKLETLTLDLDSHGASYYIDALAAVLGRCPSLRVLHLHNVFRRLKFRSRCLPTVCADPPGTLDELAAHVVKGLFAFASRLAGEVLTLDTIYIHDMVYRYGAVGIKTHWWYEGWLHVLNGNRDVDGTIQCKNIDGYVYVRLGPKCISPGFGPESYQSWCICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U296</accession>
    <name>A0AA38U296_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_339432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U296"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="18307" checksum="1D656375C78384E7" modified="2024-01-24" version="1">MIPYQIRKLTYCSLSISLIVFVFSMASNLGDNSFFLDPIASFLTIVLHLSLLWLDRRTEKLRLQPHSKISPYPISSGIPNIVCHWLLGCLWTASSVLIMFTAVFTFLDGFSNTARALVLIEPVFAAAESVLLLTIAVLITKHREAYRTQMARSSSLTGPTLRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U2V3</accession>
    <name>A0AA38U2V3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MmgE/PrpD family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_338725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U2V3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="328"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3791098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="525" mass="58169" checksum="B7DE6CBF1F7C228F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7Q4</accession>
    <name>A0AA38U7Q4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_339937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7Q4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="45563" checksum="953989DFCDAC14BA" modified="2024-01-24" version="1">MPLHRLTKGEIVNAVTRSPWTTAFRHLLPASKTLKKTLNGPALVNYSKKIVPVNERIKWWNIVPGDQVRLLGGRRGGKGGRDGRQVLLHEVVAINKFRNRVYVRGMKHDLSPESGQRTDKNYHYSRCQLFLGEHELPLKAGETERKVVSVFAQRLGTSPPVWNPYLHRWQWERFATKTVPSLPERTGERISIPWPKSRPTIHADATPLDTSEEEVLKITYKPPPFSPTLRGLLPRVPTEKEYLRSVYNRDRNSAYNKSFVTNFGNTQPPLEQFLYKELSNPHSRAKKMKRWQQAHLAKRALLNEYMKEELQDLRGRTQGEARAEAAFRCRQKLEEDKKEERKMRWVKRGGEERLERKIKMKKRKEDKKRSRLVNLVLKEGEGNQVIPKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7N4</accession>
    <name>A0AA38K7N4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793760">
        <property type="protein sequence ID" value="KAJ3780384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7N4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="79" mass="9037" checksum="A6EA0535D3CB2D54" modified="2024-01-24" version="1">MASQIVVTNRQVKFGLNNVLKKLEDVAEVDFPMCTENIVQEMATLVARMEILEEVLKQVVRKVERLKHIQAALQNEDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7Y2</accession>
    <name>A0AA38K7Y2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_278392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793618">
        <property type="protein sequence ID" value="KAJ3780984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7Y2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="69"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="496" mass="54910" checksum="A2C51711A9213E13" modified="2024-01-24" version="1">MPPEAIIKWLKQHYPRPHIHPEWLQACYDWIIGERRLNPDTDMPRIIEEVEAQLLESDLRDSMVHGTGIPQEIANFNSAHSKLTGPPILVQIEAITDVGVSAYSLNKTRLIREERRDAGEEQEGEADDEVEGEGPIPNYTRSMLRLELSDGSTTLRAAEYRPIPELILGGTPLGFKLQIQNAEIRRGIVLLQPQNIAIKGHIVSDREVNQETEFAHSLRRRLGCVDRNMPKCSSYAPKTIRLPEPVVLNGRAPLREISAPPSPTLLGGAHSHSDDEDQPRRRRIPNASPSTTSTGSSAPRTTTVVSSSLFNNTVSDKRGPNYVEAIRRALPLSPAVREPTMIESDDEDENMTWETRNRPIKPMPARARANASFSKNPSSPSGKGKEKATESDYDDDLFEQLPPSFYDEIDKVELAAGMKSLTTSSAISVAATGSSSISIDRSASFSVVPSEVITIEDEDEDDKENVPTPSRHVRPRRGGSLINIAPDDILELFDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8B3</accession>
    <name>A0AA38K8B3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha fucosidase A-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_320004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793537">
        <property type="protein sequence ID" value="KAJ3781644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8B3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF0">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="85" mass="9121" checksum="D930CA36E638887D" modified="2024-01-24" version="1">MILQSHNGEIHLLPAIPSSWTQGSVSGLRARGGFTLDIIWSGGVLSSAMLTSTLGTFTRVRYNGTAIDVSVQRNSSVILELSDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K956</accession>
    <name>A0AA38K956_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_388948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793411">
        <property type="protein sequence ID" value="KAJ3783609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K956"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13316">
        <property type="entry name" value="PH_Boi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="909"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="876"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1259" mass="135988" checksum="A6CEEBCD1BB7AC66" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K991</accession>
    <name>A0AA38K991_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peroxidase, family 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_272710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K991"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041389956" evidence="8">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3783834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="294" mass="32868" checksum="0935258A3DD29FFE" modified="2024-01-24" version="1">MRIIILSLTNLVLALSSWSAQIVFDTEAIQHHSQQFDNIDWDHHRWIVPSESDLRSPCPGMNTLANHGFISRDGRNITIPMVLEAAHGIVYNSPVNPVLNLALKLALLTTDAPDSFTLDDLKLHGTIEHDVSISRSDHALGDNLHFNPTIFSTLSESSLDPDVYDTTSVGQVLEERLALAKKVNPNLVNTVKERQSQLLEASLFLSAMGDPTTGVAPKNFVHIFFREERLPLAEGWKRSPYPMNSTSLMNLMAQLDKASQTKGPWFPSSLLTCPWTRLQPEGPEMVWPPKLFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA97</accession>
    <name>A0AA38KA97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA97"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="22347" checksum="3E73998D361AD757" modified="2024-01-24" version="1">MFVTGNAGIFARQASAISIDGSVTDLPAETPGLQATTTSEPEAVSVTGPVTMLPLESPGLQSGSLSSDVFTLSTPVLGLPSIKAESSTTSSSNHGGAIVGGVVAAIIVAVIAATLLLRYRNKSSPRHWRNRIKGGAAGPLYHKSRWQNLESKSNAANDELESGIQSGRSNIVLDDHNSPSTSPVTAKFSTPLITYPPSVSRPANDEKLPHLMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBW4</accession>
    <name>A0AA38KBW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_136473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793670">
        <property type="protein sequence ID" value="KAJ3780703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="167" mass="17248" checksum="3F4C0C4CD5EA6BB3" modified="2024-01-24" version="1">MSRWKMNTQAGPPHRYTADFHVPKTHLYFSRTTMKFFTCVSFFLLLMTGATTVNAVASTATKACSRLHQGSLNVKVNTPCKFWQSNGHAVDGTCQKRNGHHIFHSMTCVPGGSSTSSPGASSPSATSSAAVLPSSTASTDTSGASSTGDGTGSDGTGSDGMGSDGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCM9</accession>
    <name>A0AA38KCM9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAPP II complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_235963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794869">
        <property type="protein sequence ID" value="KAJ3779456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCM9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="284" mass="32512" checksum="8ECAA74555CC6029" modified="2024-01-24" version="1" fragment="single">TEGTIHASYSYIHRNPDDDGEEASVFHTRQISYPLMVTVYRMLESHGMDILPYPSYPMSTDNVAQSNSNLFVEDNGAWCLFSLDITNTYGTPFEVSIERVQEDVPWGEILVNVPPGSTSRLVIPLKKFLLSDDHTSRPIPTLSDRQFVVDKTKLSDAEQKMQRELFWYREELFKSLRCQWREAGGTRYGNLSLRQQRLTLTMLETIRTERAGIQMSFVRSGDSTEPIEHRAGKYHPPCSELVYVRIKVTNLTTTALVFTLDVNIDPREHVIHDGILCDIPVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCW6</accession>
    <name>A0AA38KCW6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794106">
        <property type="protein sequence ID" value="KAJ3779876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCW6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="120" mass="13463" checksum="52878CA999ECB224" modified="2024-01-24" version="1">MSTTSSPARPARSPTPVQDQEEVELQAYLAAAHREAHEKWRRLRKEKASGTVADERKIVEEKEVVEEDVEVEKEVVPKVEPRPRKVAIKMVAGVPRSCEVIPIISIPKKHKVEPVVAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEA9</accession>
    <name>A0AA38KEA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEA9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="377" mass="42587" checksum="7201D594B221CDB3" modified="2024-01-24" version="1">MVSLGLKRQPQSSISPAFLYYFLSSTKASSALKLLSKYLICAIILANIRGAPATWHWRVFWPIVKYNLQFLAFRVPNFFATLLDRRKRARRIAEYIDGTSPVGVHPFDFKVIYRSRVSVDESDFNMHMSNSSYPKILDFTRTKMATHLFPHFLRAGGVVPIASTHFHFVREIPMLAKFEVRAGIGAWDEKWFYVVARFVTVNHKSKSDGPSPSPSLTNSESDLVAKLVNSSKEDEEGVTLHTVAVARCCYKLGRITVPPSVLLATNGVCVYPHEVTLTELDPTIPGALDTIQSRYSVVNPPHTWTNHARKLALNPKNLRAFYQGAWRKDSTRWWESAMGTGGPMEESLKERLTICRKLFEGMDGIRQFTEPATVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEM3</accession>
    <name>A0AA38KEM3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_67858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793443">
        <property type="protein sequence ID" value="KAJ3782981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEM3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="85" mass="9079" checksum="18DDA86F1AA811C6" modified="2024-01-24" version="1">MSGDSDTEEIQSPAVASNSTQSREIPVLIEQNSSQSVGYSVASVAAVILAGSIAHLFLTWGGFTGQKGWDKLIAVEDWVAAFFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KES8</accession>
    <name>A0AA38KES8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_361664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793434">
        <property type="protein sequence ID" value="KAJ3783146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KES8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="287" mass="31205" checksum="B03FFB4752D2F557" modified="2024-01-24" version="1">MSSVHAISITSPKYVQTTIINGICPDLALKSSDSILFYVHTNLLNSVSSNKFQGHAYANNGTIVNLIEDSQVLTVILDIMYRRPSAAVDFAPPFSFDILAAAISHLSAYGVDIQALVSLNSDVNALAQPILQALQAHAPTNALPLYVLAAQHNMEALAVAASTYLVGFQLVELTDEQAEAMGPHYLRRLMLMQTQREEALKRILLQPPYPHSSTPECDVLDQKALTRVWALTAASFAWDIRADLPSTALEGLLGQLAGHISCGLCKQSIREQVTRIVAEWEAVKGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFQ7</accession>
    <name>A0AA38KFQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_435226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793375">
        <property type="protein sequence ID" value="KAJ3784481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="118"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="248" mass="26978" checksum="FADC78A768146C4C" modified="2024-01-24" version="1">MSHHSTSSPGFGMEGPRRASPTNFNTVTEGDGNPSMDSSRRTESKHNSLPPLPMPPPAARGSGDATRGSEIPRTLDTTQSPTRRSNIDWIVPLEPERKETTHRPKTVGERLLPTLQNAEAERANYALRAKMTSLALNIAIGLQVLLGALTTAISAATSGRQTSIAVSVLGGLSTLVASYLARARGSNEPELSTIRVKDLDEFIRECKAYEMDFGHLTGHTCDERLQKFRSRFEELLGNANGERRLATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFX0</accession>
    <name>A0AA38KFX0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_309155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFX0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="37635" checksum="86ACE9ACFB378A26" modified="2024-01-24" version="1">MTKVPLLLTGATGYIGGTVLTRFLQRPDASSFDIRLLVRSDEKAKAIQDLKLPVTVVIGSHTNAELMEQLASQVDVVIATADCDSVEAAQSTLKGLKKRHEMTGKKPIFIHTSGTGVYADLVNGKHADSEVFDDTNPKQIESLPPTAPHRPVDLTIVAGDAEGYLHSYIILPSTVWGTATGPLFDAKISNSHSIQIPYAARAALARGQGGMLTEGKNVWPIVEIHELGDLYSLVYDAIQNKHPMAGHGREGFYNAGHEEYSMRQLATSISEVLVQVKRGTNPEPSSFTPEEREKYFGVCRFGPFFGSNSRCLSVRSKAIGWSPKKGLKEMLASVQYEIEALIAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG81</accession>
    <name>A0AA38KG81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_355071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG81"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="147" mass="16309" checksum="029C7503769DC1F5" modified="2024-01-24" version="1">MESSFNTFVYANSYLPQSVTSLPAYTRRPSPQLRARREMTEHVAELSSDITNKRAKPWATLRVCSKAPAGTLPTFVEGEKITGSVTLDSGMSHSRHISCVKIIVSFFAYGRLMTKTSFGDFGPDDGFGRARLSSRLSKYPRSPPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGC0</accession>
    <name>A0AA38KGC0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793337">
        <property type="protein sequence ID" value="KAJ3785591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGC0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="281" mass="29657" checksum="851B8ABA957BE36A" modified="2024-01-24" version="1">MSDPPPGMNTSMSTTNNLRGGDPFGSIGNTTAFDRQMLADVFGGLGGNVMENDPDSASGLNPGPGHAARTDRTGDTSFGVVGSLAGVHAISTLPNMPNISNISSMPISIPPDFDMDMNGADFSMDAIGGSMSMGANTNMDADDDSKTAETLPALKKRRLEKDKDKGKEKGKEKEKGKEKEIVIPASPASLTDVQGGGGRGGGRESEDERTNQRPKKQPKVAKSKPGSDRDKERSLQAATGSERERDKDKERSGSKMKSHKSEVVRDKDRDRGKDSGASATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHS9</accession>
    <name>A0AA38KHS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_385157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHS9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="338" mass="37948" checksum="D7252A41BA6BBFD3" modified="2024-01-24" version="1">MTSSKIQQSLNLIADPEDEAVQSHLKALQNELEELHDEGYLFQPEIYSEDECVKLTNSLNAKIQQISASLVRACCGSPGNLSSMSKSKISAEDLLQIQTIRPLIGKLAVEFFLDSPSSQHTGSSDNRKYMYIIRCAIQTTLAALCGEIINAWSFNKEENKMLSSIYNSLRNQFGTWRSLTRSQSKIPEYHHLKPAAIRSYIAETAKVLVLSGYISWNLDDTQGIIQEYFEEEFADLYNYCFRLDRVTGESIQSFDTEVYRPEPGEAYEHASMYNMESSTKSRKSSSSTTKIAFSCRLGLLKFGTIKPENGGSEPEDEILLKAGIQFASLLSDFETAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKA5</accession>
    <name>A0AA38KKA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_180580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794043">
        <property type="protein sequence ID" value="KAJ3779939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="591" mass="66300" checksum="D2F2FD180FC9D775" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL46</accession>
    <name>A0AA38KL46_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_229791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793594">
        <property type="protein sequence ID" value="KAJ3781154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL46"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="210" mass="23810" checksum="2D23F06904F6826F" modified="2024-01-24" version="1" fragment="single">LSNEHGAKWMKDGDHAKEWARKWEADIKVNFEAYKTIVEFVPVSQDLGNNESLREVERVSSLKEGCIKRARWIKPVERRGSRQRVTHAILSFDGPESANQAISNGVIVQGKPLEARRSLPEPRRCLKCQKLGHFARECKRNGDVCGRCAGQHSTGSCSSNERFCPNCNTQGHGAVDRSCPSFTGRIRALHERRSDIQYRFFVTDAPETWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMG4</accession>
    <name>A0AA38KMG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA helicase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_399786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794401">
        <property type="protein sequence ID" value="KAJ3779676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMG4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="2">
        <location>
            <begin position="54"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="240" mass="26796" checksum="06A99F43C339936E" modified="2024-01-24" version="1">MDSFDNLQYDSASSYGGMESHHGGRTGHNHSHSVKIGLDEDFDAVLDDLKDEGVVDLPPHACSYCGIHSPASVVKCHVCSKWFCNSRGNTSASHIVNHLVRAMHKEVILHAESPLGETTPECYNCGSKNVFMLGFIPAKSDTVVVLLCRQPCAAISKEIQWNATLWAPLIDDRSFLSWLVKPPSETEQLRSRQISFAQINRLEDLWRENANASLEDLEKPWCRRRAAAYHITIRGCVPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPD8</accession>
    <name>A0AA38KPD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK endonuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_9108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPD8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK endonuclease-like" evidence="2">
        <location>
            <begin position="113"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="962" mass="109191" checksum="6D32595B7B86F0A3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPG3</accession>
    <name>A0AA38KPG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_390331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793521">
        <property type="protein sequence ID" value="KAJ3781836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPG3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="312" mass="33495" checksum="C89B546DF078C3FE" modified="2024-01-24" version="1">MLSSSWIIATFFGFCAVLLSSLAVLALPTGPIIVPSFQDASSNDASKHLATDLERRFLSSRTVQAPICRNLTKDEFNDLPGANKLKELATTTWGKGSKLNFNDKDEPGYPAQICAQQQVTIKYSGSPECHTTNATTQGELSGTTGTVAIAVAQGSTLTAQFTVSSAASISLSDTYMASVSFPAIVDVMDASTVNVAITNTQTESFMTQHNDMTTMTLTMSATEGKTCTAIESVKSCTLQGVGELRLEAVGWAGFYYGDPVGDKTDKDKNKEKHYKWFLKIEDHLTLEERSSVVTFNGPITTNTHGGYKGTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPX2</accession>
    <name>A0AA38KPX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_356474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793360">
        <property type="protein sequence ID" value="KAJ3784890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPX2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="522" mass="58229" checksum="762261FBDD27F92D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ54</accession>
    <name>A0AA38KQ54_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase pc-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_72991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793454">
        <property type="protein sequence ID" value="KAJ3782781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3782781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="643" mass="73488" checksum="519C1A54DCD31AC7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQN8</accession>
    <name>A0AA38KQN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="12">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_350882</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="12"/>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQN8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF6">
        <property type="entry name" value="ENDOGLUCANASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041320849" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="14">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="15">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3786749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="35815" checksum="58BC16634BC613C5" modified="2024-01-24" version="1">MRKILILFIFLSTLFLLSPVSAHGYLAQLTINGKSYPGNVPGAQPTSSVIRQVSDISPVKGASNPDLNCGLSAQFAADVADANPGDDLAFDWRGGDDQNWPHNTGPMLTYMTSCGSSSCTTYNSSSSKWFKIQQVARISTGGPWAQEAVMEGFPANVTLPSTLAPGNYLIRHEILGLQGAVSVGGAEFYPACSQIKVGGSQTGGPSEDELVLLPGAYSDTDPGIYDPNVYDPSASYTFPGPPVAAFAGGDASGTSVSGDASASASAAGSSSTGINGSGSSSSSSSSSSSNTQGVCKLQRRTTSSLASDVNSDLSYLVKVSNPHTHKRRRSILTGLFRDLALVYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQX0</accession>
    <name>A0AA38KQX0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_417292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQX0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="425"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="547" mass="58627" checksum="823A6A0F5E5140FD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR12</accession>
    <name>A0AA38KR12_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_272499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="417"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="721" mass="81953" checksum="8030B60D86529974" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRK4</accession>
    <name>A0AA38KRK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_393725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRK4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="112"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="559" mass="60947" checksum="8BD99665786EC17C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSL7</accession>
    <name>A0AA38KSL7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SWI/SNF complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_261263</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSL7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIRM" evidence="11">
        <location>
            <begin position="106"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="353"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="358"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="582"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3789149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="688" mass="74607" checksum="0FB8527E2C6CF8C6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSQ4</accession>
    <name>A0AA38KSQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794445">
        <property type="protein sequence ID" value="KAJ3779652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="263" mass="29789" checksum="BC1A2465BE5BD2E9" modified="2024-01-24" version="1">MAMFLKTSGCLRIALSAFDREVHSCTALNGELCSTCEALSEASYTSTSVDMPRFSKKLVPNITENSNELVSNTVAINAANLNAQHQEGEEQLNLFNEVLESIDRIGCLDCWVNNQFHNESTVHIRPWGFPAILATLRQLQMKSTEHWPFCYECWIPFRRPCNHPPPFPNKRLDPERCIHRVKDQTSQKYTPLLPTLIAIIFSYKDGVTKQRSLLSLAECKAGMKWKSLGDLADWLHKPVESSSQVPNPVVFVISFYKGSRSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT91</accession>
    <name>A0AA38KT91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_279651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793811">
        <property type="protein sequence ID" value="KAJ3780282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT91"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="371" mass="41770" checksum="7387F9B05032393B" modified="2024-01-24" version="1">MPNPSGSNGHQNGTRPSDDRLWEVLHELARRNLSLALRLDYLEKKEGYKIGKTKLKELNHQFNVPTVRKPPPLPVATTIVSETVAQDIAGQNGPSTIQQIIRNGQVWAIIHDNYPHGAEARFPGKQVPRPRGLLKLGEGIFQEVHCDGHEKMNAKALRMGPVSIDIYGMQCHSSGKILHEFVVPNARCSSTIGHIYLDFVSKYGKTCEQLTVDGGSETGEMYACHIALWFYMPNLTKCGFVALPSTKNIVIEGSWGHWLKFRGTTIRSAIELGREQGYFQSNNELHVNLFNWIWPKIVQAAVDEFIDYWNNHKTRTQHKANLPTGVAPNVIFDFPQNYGLVNCGVQVDLASIVALQETIPKTRDECYRWVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTC5</accession>
    <name>A0AA38KTC5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_279497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793759">
        <property type="protein sequence ID" value="KAJ3780387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTC5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="94" mass="10635" checksum="E9A139F0568BDB72" modified="2024-01-24" version="1" fragment="single">MLRDCFYPTSLSLENPQCIHKTHGNPILVEALKKLSLEGRLKFNRDIEVKNEARRLKSINHAMGNASRPGSPTASFVMVDSEEIDLIRKEPAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTK6</accession>
    <name>A0AA38KTK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_433314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041436971" evidence="2">
        <location>
            <begin position="26"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="35119" checksum="12B1D52B18CEC330" modified="2024-01-24" version="1">MYKMISNPSALLVAVLAMSAVTTFAAPIPIRSGTAVARDAPVVDARSVDTVIPEKRAEAVDIGRRFPRRSLYDYHTHVAREEAAKREPAPEPAKKPKKKRSNKKGKRSKRSLAAKEKRSCPCSSGSSSTSGAASGAGSSSSGTGDNSSAGSAAGSTAGAGAGSSSSSTSGSSSSSGSMSGSCGSSSSASSSTDSGSGASASGTPGSSDSGSSTDSGSAAAAGSSDSGSATSSAAGTSATGTTGSADSGSSTDSGSSASGAANSTDTGSSTDSASGTSASGTSGSTDTASGAAATDAASGSTTSGSSTDAASGAAATDAASGSTTDAASGAAATDASSASTPASTAAGASSSAAAKRRQIRSRFSSRTTPVGPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUB7</accession>
    <name>A0AA38KUB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">GGU10DRAFT_365335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="MU793517">
        <property type="protein sequence ID" value="KAJ3781872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="113"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="34942" checksum="FC13CE39BFCE3992" modified="2024-01-24" version="1">MGRKNSEASPSNSRGRRGGRGSGSKRGAPTRSGGRFNSERVLDDRKPGSAIDSVKDELEPLTDGEQESEHRIDVPVAMWDFNHCDPRRCSGKKLARLGLIKELKIGQGRFRGIVVSPKGTQVISPSDRDIILQNGLAVVECSWARLDDVPFGKIASPHERLLPYLLATNPTNYGKPWRLNCVEALAAAFYITGFDSYAEILLAGFGWGGSFWKVNRYFLEKYKKCSTAAEVVVTQDQIIEELESDWEESRRGKNIHAGDSEDLLFENPNHQRQYLSDEDIGSVSGDSERDLDGESDEKQVDQEESLSALTNHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUL0</accession>
    <name>A0AA38KUL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_364248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="MU793488">
        <property type="protein sequence ID" value="KAJ3782262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUL0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3782262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="463" mass="52092" checksum="E419D2521E90A38B" modified="2024-01-24" version="1">MSNQPTKQKLWGGRFTGNTDPLMHTFNQSLAYDQRMHSADIQGSIAYAKALKRVGILNEDEETKMIAGLQAVGKEWEDGTFKPAPDDEDIHTANERRLSELIGPLGGKLHTGRSRNDQVATDMRLWLLEEIKEVENGLRGLIRVMVERADKEKDYLMPGYTHLQRGQPIRWSHLLLSHAFSFRSDLERLQQLIPRISVLPLGSGALAGNPFVVDREFLAKELGFQSVAENSLWGVGDRDFIVEFLMWSSLAMTHISRMAEDLIIYSTAEFGFVTLSDAYSTGSSIMPQKKNPDSLELLRGKSGRVFGNMAGFVMTLKGLPSTYNKDLQEDKEPLFDALVNVSMSFKIAEGVIATLDVHPERMRQALTMDVLATDLADYLVRKGIPFRETHHISGRAVALAESRKCQLNELTFADYKSLNDKFTEDVHDVFDFEASVERRQAIGGPSRKMIDRQITVLREVLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW46</accession>
    <name>A0AA38KW46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_398712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW46"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="488" mass="54179" checksum="CFE8B8E5DEDE348A" modified="2024-01-24" version="1" fragment="single">LSDSDNPFFIPNLTYTQSEESKVIRILDTRLFPWVLLTTFVLNMDRTNLSNAVSDNLPEDLGFTTDTVNLGTAIYSVLFSLACLGGAVVCKIVHPARWIPISMFCWGLVTMAHALIQNKGGFLTVIAVTEGGVIPATLIYLGSFYRSTELATRLAWFWGVQTIASAVSGLLASGLLQLQGVSGLEGWKWLFLVDGIITVVVSVLTWYVFYLPRNAMLTKGGIRGLKPWFDARQVQIAVTRIVRDDPSKRLYEQRVHWADIKDAVTDVGLWGHLLITAVGLTPTSPLSVYLPSVIKTFDFSIFVANALTAPPYILQCCTTVLFIWHSDRVGERGFHGAFGATWQLVGWILLRCLPSDTSKGVRYFAALIVACWPYTHPLNIAWMSENTGSIGKRTLASGCVIFAANIYGVWGSQIYQAKDAPDYHTGNTINIVFAATAVCLWFVQKSYYKWKNAKNERISGRLSGVEQKREELSAEEKGNKSVLFRFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW60</accession>
    <name>A0AA38KW60_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLAC8 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793343">
        <property type="protein sequence ID" value="KAJ3785412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="300" mass="32136" checksum="E0EB34EC441A7A98" modified="2024-01-24" version="1">MSSPLVSGSIHKHEFGERGTSSAKGVPVSKTELAPGSSSTSTPPNYSELNPLETRSDLNKTKLASADTPNSHDDGPLGISTGWVSNSSSHLFSPSAQQNRSSNTPAYERSSSYSQNLPSVLSNAQVVSTQPSPMENMVPQITGSRNARKRPVDLRGKRDWNSGLCGCNAGDDHEMDICCKACFCPCIIFGRNKARIDHLANHNSPEPTGEMNGGGCAVHGIMTSLSLLGGCVMQIPLRATIRDRYSIAGSCFGDCCTSIFCYPCALTQEYIEISAEEHSFPRGVGGSSGIYYDDPKRYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWN3</accession>
    <name>A0AA38KWN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_139160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793689">
        <property type="protein sequence ID" value="KAJ3780608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="169" mass="19259" checksum="C9CB73BCEFB416C7" modified="2024-01-24" version="1">MKCSESRAASPTLTAFSGISNHRTDSYKSISENATSVPQIDYRSLAPPNSRSTARQKLSRLTIRQSHELSTDVYDELIRRKSEKEVPFLQVRAGFHPKRNQARQKLATLSTSRFEDLSSDVYFELARRYPEFKEDREELRLGPIMMIIPLLVFPPHGQLALGHPISITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWP8</accession>
    <name>A0AA38KWP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">GGU10DRAFT_386797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793318">
        <property type="protein sequence ID" value="KAJ3786297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWP8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="462"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="604"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="690"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="690"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3786297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="730" mass="80295" checksum="1861EF39FB46CA17" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX94</accession>
    <name>A0AA38KX94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_433265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3787242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="539" mass="61051" checksum="2E37724D5E826F7C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXN0</accession>
    <name>A0AA38KXN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_84053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793489">
        <property type="protein sequence ID" value="KAJ3782243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="287" mass="32041" checksum="73FBCCC1F21FD15E" modified="2024-01-24" version="1">MATISTVVDHVRVPARALQTSTDTFLRWHDAEVASALKGVAAANEQERLLRIDLQNQLQTSEQNLRACKKHLKLLQTSEQKVTCEIQKANADSTRVQQVETEVKTITDALAKIGIRLLKDTEGEFVWLQLICDLDADVRWAQVQRQYFTEYEHRDGIYPSRPSHGPFGPLTSQKSFRERPLDAIAAIDALLDALNKHIAEKYALGVRCDTVENEVAQLKTELEAKNSRIAELEVMVASHRGEESFSAGGVPKVTCIRPSQLMKDLYHSPYLSEASGSSPISTDPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXS3</accession>
    <name>A0AA38KXS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_318572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="591" mass="66801" checksum="8409CA7F3A746318" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZ88</accession>
    <name>A0AA38KZ88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_356051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZ88"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="69"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="330" mass="35605" checksum="C4206C6F4DE70FFB" modified="2024-01-24" version="1">MASVLPSSSTTPSASNVNSFLSAAEREAIKAATFQRLHPRIYLERFLEEKIRPDGRPTAENIEEPNVWRNVEVNVGSITTAPGSALVRIGKTTVVCGIKAEICEPELDNPDEGFLVPNVDLPALCSPKFKPGPPTEEAQVLSERLNEVLGNGMLSLSSLCICSGKSAWVLYVDATVINYDGNVFDATLLAMVCALKNVSLPHADYDPELHRTVCTRSETDPSKPARKLAIQEDLVPLAFSFGVFAGSHLLPDPTASEETLLDTYISVILDAHAQVLSVSQLGAGVDNYEALDQGVNNLPSSREADTLARCISLAKKRQAVLIKKVYNTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L040</accession>
    <name>A0AA38L040_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_417156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L040"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="70406" checksum="2C7FE93145E386D2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1M7</accession>
    <name>A0AA38L1M7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_419648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU793946">
        <property type="protein sequence ID" value="KAJ3780067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1M7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="49"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3780067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="422" mass="45526" checksum="CF9BDE85E85AFFEB" modified="2024-01-24" version="1">MFLTKPLRLVLQSTTIVAILAACVGATILYAGVNESGGEFGEFGTLGTGLPGEFGVTYDFITESTVDTFVDTNQINFFRVTFLMERMCPLATGLGSTFNETYFSEYEDAINYITVTKGAYALIDPHNYMAGRVSSNSFVVSADSSFNRDTSTIPHIKSYLQLISSRFSDPSSQPNSGSIIGDTTDPNAATTEQFQEFWTELASRFVDNPQVVFGINNEPHDMATSLILQNDQAAINGIRSTGATQLILAPGNGFTGGHSWTQVTGANDDPSSEWLNQIVDPLNNTAIDIHEYLDEDFSGSHDTCTQPGPSNLAALTTWLQENNLKAVVSEFGGSNDPTCLELVPELINYLSENDVYIGWSAWAAGPFWGTNSPCCGPEVGSLEPGQLDEEGGPNGYTTVWQAVIQPNIDLSDLKRSGVSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2L2</accession>
    <name>A0AA38L2L2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793847">
        <property type="protein sequence ID" value="KAJ3780220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2L2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="66643" checksum="2DDB647AF073616A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2Y6</accession>
    <name>A0AA38L2Y6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_414681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793659">
        <property type="protein sequence ID" value="KAJ3780760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2Y6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="37"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="32192" checksum="8A3B0CDA9B3DEA54" modified="2024-01-24" version="1">MFIVPASISAPRFPLLHIEDDCFHSEASTTSIASRDEDHTYIRPTFPNDSRAPCPGLNTLANHGYIPRSGRDISFLTLVRAIMEVYNISLPLALMLTVPGFLIYARFQLHWNSSASFSDTESISKSFPSISYSITLSSLASFGPGLKIAHRASLVHPDYPSEKPDTNMLHGFLNYARLSDEQRGCFTIHDLASFRVSRESNLQGPNKLDGIHEQVALGESSLTWLLFAKQISSSTSPEISLSYLEQWFGEERIPDGWTRPTETIGLINARKVAGQVQNEMKMVREAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L345</accession>
    <name>A0AA38L345_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_278220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="MU793607">
        <property type="protein sequence ID" value="KAJ3781075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L345"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041448902" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="337"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="441" mass="48532" checksum="982F4E94E2F44155" modified="2024-01-24" version="1">MLRPTGVFVLGAAVLFTASLSPTLINALDNGVGKLPALGYNTWNAYGCNINEDLVLESAQLMVSLGLQAAGYEYVNIDDCYAEKNRSASGDIVADSVRFAQGMKNLTDQIHALGFKTGIYSDSGWFTCGGYPGSFQNELRDATTFQDWGFDYLKFDNCAIPFDDIIREGMIGKYTRMADALAQLSKSSGQPPFLFSLCQWGWEQVWLWGSTLGHSWRVIGVFLMDIAPDWDSLAYIINFNSFITQATSFYGHNDMDMVCVWNGGLTFDEAKSHFTAWALMKSPLLIGTNLSAITPDILQILTNTEILSINQDPVVGKSISPFRWGINPDWTSNSTFPAQYYSGPSENGTVFMLLNTLNETSDMFFNLTESPWIRAGRQYSVRDLCTHTDNGTAVRNFTAANVPPHGVVALLLEDAGDEPAGIFPPCAVWFNCAYENGTAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L359</accession>
    <name>A0AA38L359_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_436176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793437">
        <property type="protein sequence ID" value="KAJ3783082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L359"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="167"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="35282" checksum="8766A95B2FD82262" modified="2024-01-24" version="1">MSSNVEIASTFGSLLIGALLASFLSGGVTIQTLVYYKLYPTDGSSIKTLVFAIWLLDTCHTGLIWGSQWEYFIGFYGMDEKIDYIPTTLALSIAITGILTVLVHAFFAHRIFLLSKRKWSLVVPVVIIAVLRLVSSTATTATMLHYRSFVQFRQHVRWLFTLGLALSSAVDVLITSSLFFLLRSSKREGGSLDGVIDALILYTFETGSVTCAATIVSMICWITIPTQLIFMALHFIIGKFYATSLLVTLNTRRVLRDVHSRGSSSGRERGAFVLDNHRMNRISKDEVGSNNGYDGGKGVATELQINVERSVQYTRDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L370</accession>
    <name>A0AA38L370_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_361716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L370"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="240" mass="24488" checksum="EF8A961B4208FC30" modified="2024-01-24" version="1">MSGSIETGKIFNVAEPTGADAARAETTAAQAQAEAPTSEASRAVEYNAEQLQGAAQHAALAAKSLGKEFTGEPPSAADQLQAKTNSAVAQGKADVDAAKVEGQSYLEQAKNLAGSAISSAQYYLPNSNPATHPSTGGSTAITDTLSQIQAGATTVLATGKEYLASAQNTAQPHIDRALEAAQPHINKVSEATSNYIKNVNGETDTSNSVPPRIPATSAPLESGPHVVTTPYPSTTTKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3D9</accession>
    <name>A0AA38L3D9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_437281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793554">
        <property type="protein sequence ID" value="KAJ3781480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3D9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24130" checksum="61F9784438E905B9" modified="2024-01-24" version="1">MSSSSRLSSILSVSPKYLSVFLCAESSLSQKHLSSEKVAADYKGMGSSWALDVKIARRAQAAALYGINMVLYSAGEGGTLLIHSLSSAGEWDPVLLMHTVQFRRCVVFFTSIERLHYAKRYRPHIPHEWGLCRFCETGIEDECHALLTCTSCSTLSHLRKCFLEDLFDITPFLKVIYTQSGTRLEIDISQVQSSACSTSQIIKDQSRYSVGKTWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4D9</accession>
    <name>A0AA38L4D9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_6746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793347">
        <property type="protein sequence ID" value="KAJ3785272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4D9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3785272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="121" mass="13624" checksum="3BE1F77F95507701" modified="2024-01-24" version="1">MSSTSSFKDRQLLAVIGDEDSITGLLLAGIGHVNEQQKKNFLVVDSKTQVSQIEAAFQEFTERKDIAILLINQHIAEKIRPTVDKYQQAFPALLEIPSKDHPYDPSKDSILKRVQKLFGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4U2</accession>
    <name>A0AA38L4U2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_427586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4U2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="598" mass="63632" checksum="55C2DBD8DF18F66C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5R3</accession>
    <name>A0AA38L5R3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_347832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5R3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="128"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="233" mass="25530" checksum="8F7F847890C2AED4" modified="2024-01-24" version="1">MTRRGAFVVVEGLDRSGKTTQTGILRQRIQEAGKEVICVKFPDRSTPIGKMIDAYLRSQSDLDDHVVHLLFSANRWELASTIISSLEQGKIVLCDRYAFSGIAFSVAKSLPSQSSPSTALQTPGKLPPISLHWARAPDAALPSPDLTLFLDVSPEIALTRGGYGEERYEKADMQKRVRSVFREIGGEVTADAGQGKWIVVDAGKDMSTVTEEMWGHVQTLLDGINGSIGRLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6I6</accession>
    <name>A0AA38L6I6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acetyl-CoA acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_385712</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6I6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="16"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="279"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3787600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="407" mass="42510" checksum="E5A78A88A3ACD3AB" modified="2024-01-24" version="1">MSAARSKILEKHDDDVVIVSAIRSALTKSKKGGFKDTRPEEILMNVLKHTYTSTKLDPALIEDVVVGNVLPPSGGASAARMAAIAAGIPIATPITTVNRQCSSGLTAVSQIANSIKSGQIDIGIGAGVESMTFGYGAGAMPDGYSELVLENQEAEDCLIPMGITSENVAADYNISREAQDTFAALSFQKAAAAQKANLFEPEILPIRVKQVSPDGGKQFLVEYDDGVRDGVTAESLAKLKPAFKKDGSTHAGNASQVSDGAAAVLLARRSVAKKLGLPIVGKFVAAQAVGVPPRIMGVGPAFAIPHVLKKTGLQMSDIDFFEINEAFASQALFCCEQLGIPWKEAGLNGKVNRWGGAIAIGHPLGCTGARQIATGLNIAKHDNEKVFVTSMCIGSGMGMAGVFVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6P0</accession>
    <name>A0AA38L6P0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_287369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6P0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="513" mass="57874" checksum="F1B3E35C30B50AFF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB67</accession>
    <name>A0AA38NB67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_321878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793843">
        <property type="protein sequence ID" value="KAJ3780226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB67"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="854"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="854"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112117" checksum="AEDF0FF2FED90BB5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBS2</accession>
    <name>A0AA38NBS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_93067</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="MU793513">
        <property type="protein sequence ID" value="KAJ3781921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBS2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="590"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="969"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1133"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="988"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1020"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1143"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3781921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1205" mass="132622" checksum="B9EEECB911A3B29A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC53</accession>
    <name>A0AA38NC53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_68523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793445">
        <property type="protein sequence ID" value="KAJ3782926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC53"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="95"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="247"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="459" mass="50331" checksum="BB56DA6A40875C1F" modified="2024-01-24" version="1">METPAPLQPDEKATTLTTLSQLLVSIEESTAVLRESIEKQLSSSSDNLDFSEIAASTLHLQFHADASVALHASKLRVACERLAQVVTPPRHLVFEAAGSFYLTAALDITVKSDIATIIHTHSSQSGAEGVPVDVLAQESKLDSDLLARLMRHLAVFGIFKEISLNTFANTAASSTLINNPEFRAHLDLVMHEGRAAIPFFPEIVSKRYSDAVPPPSAFFLYSNGQLFYDWLHSPSQTDRNANFNIAMRGMAHTEGLAFLPADYPFHVLPADKVIVDVGGGIGSLPTILLPSLPDHSFIIQDLEPVVNQAVEGASLSMKRWMDQGRIRFLVQDCFTPQPPELDGAVFILKNMIHNYPDSRALAILSNLRKTNPYKLLVIDRLVIPQLKSDNNQSLTVPHGGTGSQRAATFYDLVMASLHGGKNRTLEDWRKLLEQGGFKLEKIYPLRASTGQAVIEASCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIB2</accession>
    <name>A0AA38NIB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF757-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_360632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793416">
        <property type="protein sequence ID" value="KAJ3783497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="2">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="173" mass="20430" checksum="C1817C26E87BA85D" modified="2024-01-24" version="1">MAGKFDPQNAQNLVEIEKQFAVKAVEQAQTYWNLLAKVAPNELRLTKLDDEIFQHTMETFPELAKEPHENLTKLDEDWMKSPEGKERWRKFIMSYEKKIKDHNFGSLIRMDARDEYAEKNTIFVTRIQFYAIEISRNRLGLNDKAHELAKEEAEKERLEKEQAEAKKKKKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIJ1</accession>
    <name>A0AA38NIJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794174">
        <property type="protein sequence ID" value="KAJ3779823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="201" mass="22776" checksum="FCBB0197C1A00F04" modified="2024-01-24" version="1">MHLRPAEEDELVRFAETFQIEIGHERDTWLASKMISLLPHKLDTIQPQNTKFEISAALNSKIEEQLVNLFLNPAVPAYLGQLNENLMACKKMLKKSSLNLLPKQVRELKPMKVIESKIGSRFTHHRNEAKAILCKSVGKFNKNMKASEGPFIDIVVLTRAFVTGVARAILKDDQQKYKVQVADDVVEHLDSLALVPLPHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIT5</accession>
    <name>A0AA38NIT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_357630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="334" mass="38558" checksum="18918CB101720430" modified="2024-01-24" version="1">MPPKKQQQASSSKVKEDKTFGMKNKNKSAKVQKEVQRIQQQSALAGKSRAVLDKEKEQKLRTKTKEEEEKRRKEDVALLNPVITQPKVPFGVDPKTLLCAFYKAGQCDKGNKCKFSHDLNVGRKVEKKNLYEDTRAEKEADTMDTWDDEKLRKVVISKAGNPRTTTDIVCKFFIEAIETQKFGWFWECPNGENCQYRHALPPGFVLKSQKKAMEEANKANVISLEEFLEVERHKLGSNLTPCTPETFAKWKQTRLDKKTVEEEAVRKAKEVQHAAGKNTGMSGRDLFQYNPEWFEDEDEDEEDDWDLEQYRKRKEEEDMVAEAARINALSVNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIV1</accession>
    <name>A0AA38NIV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_333828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793372">
        <property type="protein sequence ID" value="KAJ3784562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="413" mass="44320" checksum="D5F32F91E462179C" modified="2024-01-24" version="1">MSPTPSSTLSGTITSTTSLSTSSGSSDVVAEVIVGGVIAGVLLALIFVGLAMFLYHEYRRRKGNKDGSGRSRKGVTTRGKSPEGSDPLLYPTFSQVGQGEFNPYAEIVSLPVRPVRPEISLDYSEIDILEPLPSSSSVMQETSLPLSTARPSLSPLLIPHATVVSPAHPSPHPTTAPTKAPTPNDNNNDPSSAVSNDDTASESSMSAYSQASASTRLYKAWEEDTQFPPIPEIPSQHQVQYISSAQATDFSDENTSLTRGNTAKLTALLKSRARRAQRGKPLSRSSTKVSRIDRNNSLESIDLIPRNRSESVKLHRDPNTLIAKSPAPSEPASLTIRNPFEDVSSSSRSTSVTTSIANHAAQTVDPPYAHRLSVIDNEEAETQSVYADEIHLKAVPDTPPLRITKNQAFGVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIW1</accession>
    <name>A0AA38NIW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_23458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIW1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041490558" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="486" mass="52000" checksum="2820DD772E53AE26" modified="2024-01-24" version="1">MLIPLFSVLLAALPSVLGGQVPIVDGVYGGVRSTTGSSRGTTKPADLSVAATTPGKIRAVENTGICETTPGVYSASGYGDLTSTESLFFWYFAARENNDTAPLALWFNGGPGSSSMLGLFQELGPCRINNASTAVALNPNSWNTKANLLFIDQPVGVGFSHGTMDVGTSEEAAADVWNFLQIFLSDSRFSSLQSHDLAIWTESYGGHYGPTFAAYFLSQNAAIAKGTISGITLNLKTLGVGDGLTDPLSQYPGYITYAGSNPYHALVSTSTITRANTSWLSSTGCKEQITACNNDGSNSVCSAAQSFCNNNILSPLAGNFDVYYILATNPDPYPPDLTSYLKTIETKIGAESTWQETNDDVYDNFAATGDWMRNSRPDLETVIDAGVRVVVYDGDADYILNFNGVEAMVNNLDMQFTSILQAQSFEPWTVDGQLAAQVKNAGTFSYIRIYGAGHEVPAYKFGNLAYGQAALQMFEQIMSNQSLTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ14</accession>
    <name>A0AA38NJ14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_246291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793947">
        <property type="protein sequence ID" value="KAJ3780064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ14"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="412" mass="45582" checksum="3143F30183E07443" modified="2024-01-24" version="1" fragment="single">CDFKRSGNADQARILVHAKQCKHLPRSLKVLASDTAADGVLGAKAKKDGSEQGGDAFTKSTACLVTPSSSQTKLTHDFTAQGKKDVANEINHRIMQLLCCDSIPLHVLDSPRWKNLIEYLCRNGPNRSYTPVSSTHMATSVIPNEASLVRKLTLEQLKNERNLTVTFDGGSIRKPQSIYTTHVTTEDRITYFWDGDEASDKSHNSEYVEQVIDQTVVAVGGPYKIAGVNSDNTGNVRKGRQDYTQAHSTVLNTRDSIHAFHNTIGEINKLPWIKPMITIAAKVIKYLRKSNLSSSALKKDAVQSHEIERSKGLISIGKTRFATHYSSLASLEPHLRAIQRLVEDKKIDIKANKAIKSFFTSRGEVNSFETTMYQYLAIIGPIAQSLWSLESTVANAADVYVFWLAIAATCND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ55</accession>
    <name>A0AA38NJ55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_11841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="255"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="320" mass="35218" checksum="FA068D72BFBCE5FF" modified="2024-01-24" version="1">MLVSENSLLSHPFFLLTTVFANAAWIIALISQALATREYGRSTVATLWLATLLQLFVNTGVLYGLYTNSIHILRLQIAVFASMSVVLGALGIDSNVFSNVGSRDAIAAAWIILSIVDLLWILVLSSERDSPVLQVFAEEARIRLSSDSHLPVNHDEERQTLVLTTAPMLSESKELSPDPRNTLYSIQETSKTEDTARPALPPFHPPPTDNEASRTSISKPSEYNVTNDRQSTRSRLTVPSITTHGSSNAPSSNYSYSQRALTLYDYTAISVGDSGEEELSFAKGEILEVSRTFEKKWWPARKSNGQIGVVPSNYVKVIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJD2</accession>
    <name>A0AA38NJD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_321518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793690">
        <property type="protein sequence ID" value="KAJ3780604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJD2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="106" mass="11050" checksum="EED966A2F31C1B4D" modified="2024-01-24" version="1">MSLLLRTTISRVSATSSVRAFHASPTASKTITEKVSEVADNVNKKLGKGLASAIDKGEQATASTQDSLGNAARKTQESATAAKQKANQASAGATQAKEDFKKEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJQ3</accession>
    <name>A0AA38NJQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793519">
        <property type="protein sequence ID" value="KAJ3781848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041298172" evidence="1">
        <location>
            <begin position="17"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="406" mass="46448" checksum="A996644BD52C190F" modified="2024-01-24" version="1">MAHSSLQPALVVVILAFDLLIFLNRERAPSQPALPSGTPPPGSSFGNRVKNMIRNWMLLLQRVVIPSLVFPKEHYSDEWRWDRKLFFQTFYTNMTKSINISCETVSIASRPCAAYYGVRNGLSLAVEAQDTFAKSQSIDAFPVIERFPWLRYMPSWFPGCDFGKVAAQCFEKDKIIDTVPFEMAMNRSHSIAYLSRNPDFKLGNLIIVELAEQNEGNYTAIETQSEEWECSFLQAMTPHTDNTEERAIKIDRVIDQDRLPIFEDRRSSLPKYTRIQMSLCPSRDLDQEDPSRISTRCVWIQTKPDDRGGNFSEIALAGKAKDEQGTLETDIPEEFIGVLPRHSKPYQYSTRRNQDAKEVIMATSLTQPLHSSMVKSQNYCFYQLFYESSDSSVWTYAVVPGLDHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKP3</accession>
    <name>A0AA38NKP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_406677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793447">
        <property type="protein sequence ID" value="KAJ3782899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="9"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="38050" checksum="DA0C6F38EAFD1F00" modified="2024-01-24" version="1">MKAVFTIAGARVQVRDTEIPVPKEEQVLVKMVAVAQNPTDWKTIKLARIVGAVVGTDYAGTIAGVGPGVDEEKHKVGDRVAGVLHGSLNKNGAFAEYALVPVHSLIRIPDDWSFEHAAQLGVGTTTTCQCFWQSQNLPKPFERPTSPLTTVLIWSGASATGHYAIQFAKLSGMRVVTTASPKHWDRLRALGADACFDYNDPDVSEKIRAYTDNKLKYAVDCFSEKSSFQKVSDALSEEGGTISCLFPSPYKLRAGIKLKFTLAYDLLAEPYKFPKLYNPRAEDKAFGDWATDLVSEVLKSGKLVPLPMKLYPNGLESVQEGLRYMQEGKVSAEKITYRISDTPGIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKW5</accession>
    <name>A0AA38NKW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_47322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKW5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="579" mass="61711" checksum="75611F07954541EB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLG9</accession>
    <name>A0AA38NLG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cys/Met metabolism PLP-dependent enzyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_384638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLG9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="396" mass="43942" checksum="A008462934D78588" modified="2024-01-24" version="1">MTMTPKIRAVDLLHGDSSVHGERIEVAPSISVSTTFRADPDELPLDAIDLQNPTRHVYSRYTQDISTRVEHVLKKLLDGHVATYASGLAACFAALVYYKPNRIAIRGGYWGCHHTIEIYKKCRDIAVEIIDFDDEFKPGDLCWVETPVNPTGESRDIQYYADKIHRVGGKLLVDSTFAPPPLQYPFKLGADCILHSATKYIGGHSDLLAGLLVVKTEAEWLELQSDRTYMGTVMGSLESWLLLRSLRTFHLRIVRQSATATALVQWLKTVASTSKDDSFEGVPGGVLAKVFHSSLQEVDARGFHPSQQMQGGWSATFSILLSTPGYAKALPHLTKYFVPATSLGGVESLIEYRARADPNEDPTLVRISVGVEDFEDLKADLEQAFRRCKEATTNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMB1</accession>
    <name>A0AA38NMB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_311033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMB1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="76"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="476" mass="54799" checksum="2BB76075CE24508B" modified="2024-01-24" version="1">MPYLKVSGTQFVDGNGTPVVLLGAGLGGWMMMENFISGFPGCEFHIREALAEAIGIEKASLFFEKFLDNFFAEGDVKFFKSLGLNCVRIAVNYHHFEDDMNPRVLKKDAFKQLDRVVSLCAAEDIYTIIDLHSTPGGQSGGWHADAGTHFGNFWKHKDFQDRFVWLWTQIAEHYKDNIWVAGYNLMNEPADPDPGHAGLINIYDRTYAAIYSIDPHHILFLDGNTFATDFTKFPDDSATRWGTNVAFAIHDYSTFGFPSSPEVYEGTDNQKATLKAAYVRKRKWMDEGNLCVWNGEWGPVYGRKEYDGEETDDINRRRYMVLRDQLEIYRKDSLSWSIWLYKDIGFQGMVYVSQDTAYMKHFGEFLSKKHRLAVDAWGADDKYVKHIYEPIVNLIKEEIPEPNQKLYPPIWNLENRVTRISRTILVAEFMAKEWAEMFVGMGDQELVDFAESFAFEKCEKREELNSILKFSANTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMC6</accession>
    <name>A0AA38NMC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCA7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_290040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="128"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="37766" checksum="E3847A6BEE33906A" modified="2024-01-24" version="1">MPLKLKGASTPLTEPFSWDDLPSPSPPPPEVSAVTEPTTVWLPARDMKIFGARPLSSTSEIGVVRCKDCDKPILKSAATEHAANCTQIRNIAMIAQAKKRKASPSSASLPGEPASKKVKKSALPKVTKGRMKGPVDYDKQCGVINDKGLPCSRSLTCKSHAMGAKRAVQGRSRPYDDLLLDWQREHNPNFVEPVKRETKKEKKEKKDREKAERKRAIEEAAVKLGLDPSSKEGRKAGAAATGHVISTSSKHGPSKRAQAAAAAAAAASANTLDDADNENYDDLDSEAEVDDLVGAVRQARTLGVIAQPLAVPSDAGSWFVERRERFRLAYHMIGVALNPAKMSNRRTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMD0</accession>
    <name>A0AA38NMD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1295-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_351585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMD0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="335" mass="37753" checksum="5267269F6AC0CEF5" modified="2024-01-24" version="1">MAVYVLDHYYLAITVLVTTAYQLLGFAIAWTFQFDKITDFTGGSNFFILALLTLLIGNEFHARNIVASVLVMVWATRIAGFLLFRVLKTGSDNRFDEIRSNFLKFLGFWLGQILWVWTVSLPLTILNSPAISDTNRSGSNPAFGTSRDIAGIVLWVLGWLIETVSDAQKFRYKMAKGKPKDKPILTGLWKWSRHPPYFGEIMCWWGIWILCLSPTTNGSLPSSSKSAQYGAIVSPLFTLILLMFGSGVPTAEKPQAKKFFLMSYGDNAKPEHVRAWSNYQAYLRNTSILIPIPPAIYKPLPRVIKQTLLLDFPMYQFDEGRDGAAAIEQSRKNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMF8</accession>
    <name>A0AA38NMF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_419800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMF8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="441" mass="49060" checksum="C1A92F835D7D22AE" modified="2024-01-24" version="1" fragment="single">GQHMIIVNSGEIMEQLDKRGSIHSDRPRLEMAGELVGYSKTLVLVPYGQRLRNYRRYVSKMIGSLSALSQFHPMIEAETHMFLKRTAANPHSDVISHNLRKTSGSIILKLSYGIEVQEENDPFVSLIERANDNFSLATKPGAFLVDVFPSLRHIPPGFPGAKFHELAAKWAKDFNDMIEIPFNFTRELMSKGAAPVSFVSASLEHEDKLTENEIFEIKHTAASIYAAGADTTVSDQYSVFLAMVVTPFKSFCSEVLKKAQAEIDAVVGNERLPAFSDREHLPYLNAVLTEALRWNSVAPTGVPHRSMEDDIIGGYLIPKGSIIIANLWNMLNDPAVYPDPFKFDPERHISSPGKPAQKDPRHACFGFGRRICVGMQLAEASLWIFIAMTLAVFDISPVLDGQGNPIIPEHENTTGTISHPKPFQCFIRPRSEKALSLISTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NML1</accession>
    <name>A0AA38NML1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_417189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NML1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56638" checksum="255DA93B055F00D8" modified="2024-01-24" version="1">MHLQNPTRLERRLGDTETSYFLPSRESGVNDMYLHLGFSAQPRTLARDRLAHVWAILRLKHPLLACSVEMHNYDDIRFVSKPYASTEATLYSANENIIYRQGTKAELIDSYLNGPRTLSTERLSCLILSQEHSYVDESVIPSIDTEDWFDYDLLLCTTHFVGDGMALHQCANDLFTLLSSKKSTGELHDILKEEWRLRFGGQYSEMFLPKSLEERLPQYSGKFQKTASIVDFELSQGRLLGGHSFPRRRGDDRRTVVPTVAFDEARTRQVLKLCKSHNLSISSALFAICNIAWLRTRNDDPHLPTMMYSALNLRPHLLPDDLNDSYWFIAISYFNVVLPGFLPTTDVEKTFWHRARSAKEQSTRAAKNPMVIPRSKEMAKERGDRARRWAREDDGYDIGIPSPPLTATIMSKPPSAALIGLSLLGNLDGIYKHSAFPEIKLHTLTTGSRQRSGAMLLFGYTFVGKLWISLGYDENGFEKGIVEKFWKNVLTSMDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMV0</accession>
    <name>A0AA38NMV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_349391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="101"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="473" mass="51629" checksum="2AEBC8210165436B" modified="2024-01-24" version="1">MMYPSIPTHPKQRQPSSGCLGSITWRNRKFPTEFIDDPIGGRIAEPSSKRSRIEEYSTYSTKRLASDYTPLDPKFKSPLPYKRGPRMGRDQDLRAMNPPSKTLIVRNLASGSDPKIVEHQFEMYGLVEQFDELIRRRGVAFITYYDRSAAQTAFRKMQGSKIDGSVINIQFEPLSVISGDPNSNLVTDETSGKLTTCSRTPLAVIAGEKSLQASNPSNQLIGDRRRKPRPDQIQANQSTVEDRLKEAQKLQQLFSTLQCDGSSTMHNLNFLVTSKSQSDSKLSSLAEGAQGLYPGLDVVQSHSPASFVDTDLTHLLQRIKPCLLLNLSHEQPSISSPSPVAQKTSSEGELASSSPSTITLPMLESLHQALSTASATSLTKPDLDSMVAYQSINSFSAVGSPNTEPLSTIPSGSNFDGVAWPQFPVSAVTTRPISIPQWTGGDHSSMLSLLSVSEAVSGPVNQDVLSNPQKVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMZ4</accession>
    <name>A0AA38NMZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_420861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794053">
        <property type="protein sequence ID" value="KAJ3779930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="14295" checksum="D31D51F8ECA3CAE9" modified="2024-01-24" version="1">MIELKQFIEEADKNKDRKIDFEEWEVMVDRIKKKIPIAEDHVMEARKIFTIYDTNGDNNTLELNELVKLLEDLGSKITSLPATAQVASQQGKYVSRKFNKLTKKWERMSFLTNPGLSASVCWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMZ7</accession>
    <name>A0AA38NMZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_397899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794038">
        <property type="protein sequence ID" value="KAJ3779945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMZ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="243"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="767" mass="86721" checksum="66E2A8C4DEDE99C2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN08</accession>
    <name>A0AA38NN08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_347593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN08"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041480135" description="Protein kish" evidence="9">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="71" mass="7830" checksum="4E355CC3F4271D4E" modified="2024-01-24" version="1">MSALFNFQSLLLVILLAICTCTYVRSVAPRLVDRNKEGFLGLFFMAARIGERLSPYVALACISMAGTLLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNJ6</accession>
    <name>A0AA38NNJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793633">
        <property type="protein sequence ID" value="KAJ3780890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNJ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="671" mass="74430" checksum="78E38F77C89E3B6A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNW8</accession>
    <name>A0AA38NNW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_365519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793522">
        <property type="protein sequence ID" value="KAJ3781820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16578" checksum="8F321E999344C205" modified="2024-01-24" version="1">MSTNLPYGIPYVGAALLSSAILVSVQILIVAARRKTSGIQPPQLYAEQKEVATSIHAFRLNCAQRAHLNTLEYLPILYLATCITACKYPILAASLCEGWIVARLFYTRAYTSATPEKRSFWANTSLRFLLGLLASATYTVGTAMMTELQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPC1</accession>
    <name>A0AA38NPC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_388585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793390">
        <property type="protein sequence ID" value="KAJ3784115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPC1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="79" mass="8439" checksum="8556C610AABF1D37" modified="2024-01-24" version="1">MSQNSLNVGDRVEYQGIGGGNVENSTTHGEITEIVTEKQPAGDSGNVVNASSDDPRFVIRNDNTGKQTAYKADNIKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPG0</accession>
    <name>A0AA38NPG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_293686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793366">
        <property type="protein sequence ID" value="KAJ3784700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPG0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="541" mass="59175" checksum="9B619801E74AF8BF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ04</accession>
    <name>A0AA38NQ04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_348478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="364" mass="40438" checksum="79724C041382B29A" modified="2024-01-24" version="1">MASPSTEAQLKSEIERLTASINLHKSNTSTHPATGFRKNTYVNPNYKFTNKYIRPTTSTTEPSRSSIQPPTSSAEVKEVVLNGIALQSSGRSLVRKDLPQTLFNTPASTTTAQPPYVRKSGHMLTGKRVYKPKISRGRRKGNMTLTNGRRPYQTRRASKQMKYSDKQCPRFSTTGSCSHGLTCMYQHDPSKIAICWNFLQDNCPNTADTCNLSHDPIPERTPLCLHFLNKGRCTRPNCLFPHVNVGARHGICRDFAVLGYCGKGLDCDKQHVRECPDFAEKGACSTKGCKLPHVIRANRNRKPASISVLPSGLSSSIVEAGSVDAQGESSMRVKARRVTMRKMRKTKILKRATTPTMYLMSCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR57</accession>
    <name>A0AA38NR57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fusaric acid resistance protein-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_260448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR57"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="694"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="885"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121847" checksum="5F47AD652B562CB8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRE7</accession>
    <name>A0AA38NRE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_259984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRE7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="391"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="645"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="951"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1156"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1246" mass="136979" checksum="FCF415B784DB8189" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS34</accession>
    <name>A0AA38NS34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin complex subunit 54-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_303868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS34"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="586" mass="60327" checksum="3CE32D88CF429DFD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSE2</accession>
    <name>A0AA38NSE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_340986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSE2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="417" mass="45871" checksum="3D457F7D16B9BE06" modified="2024-01-24" version="1">MASSLLSRSLRLRGCSRPYGLHSVITTRLYQTDAMTGEVVALPNIQPEHLQFIQTEKPGTPPPSKSLVFGHTFTNHMLTIPWSSLEGWGTPKIEPYGPLSLEPSSTVLHYAQTIFEGMKAYRDEHGKVTLFRPDMNMKRMNSSAARVSLPTFDSDALLQLIKKLIHIERDWIPREPGHSLYIRPTMIGTQKFIGIAPPSEALLFVICSPVGPYYPDGFKPIALYATTEYIRAAPGGTGAYKLGANYAPAVMPQKQVAKMGYAQNLWLHGPEHYLTEVGTMNMFVVLKKGDTIELVTPPLDGMILPGVTRDSLLSLARDHVSGTYKIPKLPEHFIVSERPITMKEVQEAEASGNLVELFGSGTAAIISPVNRIGYLGKDIHVPTGEDGMGPISRPIWTELVGRQMGTIPSDWSVPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT90</accession>
    <name>A0AA38NT90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_339358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT90"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="993" mass="108473" checksum="2C69214714E12FC5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTA5</accession>
    <name>A0AA38NTA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_339447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041304366" evidence="2">
        <location>
            <begin position="20"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="807" mass="87696" checksum="9E334E56BE4F3689" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTM7</accession>
    <name>A0AA38NTM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pep3/Vps18/deep orange family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_101758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="54"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="464"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="642"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="888"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="849"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123075" checksum="4F7329693C593C6B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZA6</accession>
    <name>A0AA38TZA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_10533</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3790000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZA6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3790000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="265" mass="29462" checksum="C7783966E4DE3470" modified="2024-01-24" version="1">MQTPHRTPLRRISHGSLLRLSRSGAYPDAPHGLGFLEPAMSEFVDETEILQTNVEGLKHLSDTLATFNESFASWLYVMNMNALTVDWPQAPHDGSFMLAKRRAEQNAIAAMEALQAKAQAKSMQPSTSEGSMNDQTTIIDAKDTFISNSNNDSGSAKATKRVVKIKKPKLTAKEKKERALELERIVAFLPLEFRGSDPNLRRNMEAVIEGIWDAPNQTLKLPDLIKPPDLNQARANKCLIALVNRKIVQKDSSTGTVLYHWQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1D1</accession>
    <name>A0AA38U1D1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_301721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1D1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="36263" checksum="A10B1E169DC0037E" modified="2024-01-24" version="1">MSISPPSPGNRRKGPKSLPKLPLSAFTPPNSGTSEKFPLAPSPSTVHPESVIDANVVALNDDSYLSRWKSEAGPHLGSRIGGIVVSISGGDEKSLSNLNIPVLSVMVPFSLESSDRPASLPTSYPVSLTTVFTRVMPNSVENLRWALQQGRPVDIDIHVDLTDDVFESFEDLLSKSMADVSPVPPIILSNLLPPPNDLELPIVKLMNHPVYRKFQAQIAALSLFPQISIKYLPPSWDVETPPTPSIMVASPIDDNKQKKEWKRRIKMYLGPVMEAFGYQRIIFGSSPSASSKVPSKAGDWYEIARESFAELGVEQEAVDAVFWTTAKKIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1W7</accession>
    <name>A0AA38U1W7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_417947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1W7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="663" mass="76267" checksum="8C58D1A6E15252C5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U282</accession>
    <name>A0AA38U282_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_339350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U282"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="147"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="447" mass="49353" checksum="BB95E384FD60B7E9" modified="2024-01-24" version="1">MFRTVRLSPQFLKMPITRSASRATVVGPSNISAEPITPTPRIPTKRKAKENTLTPVTKEKKSRATKTALEVSSVSQAQLDEFQRNLPEPGPAPVLVPAQLTFSFEEAKKHLIDADPRFQILFDRLTCKPFERLETVHPFRALATSIIGQQISWIAARSVNHKFVRLFNPSLPEKVTDYPERADATSYFPTPQQVANTDLAILRTAGLSGRKAEYVRDLATRFSDGRLSTEKLLQANDDELAEMLTEVKGIGRWTVDMFSIFTLRRPNILPVGDLGVQRGMLRWFLGSHSPTHTFSFSPDKAGRNVQDEDELSDEEVGSLPMLNDTPASSKMTSAPQTSSAFDLSSIPPAPPATPRKEDGTETQASVASLPPPVTPSVEQTLMQVENSAGYVPPPLPAGLTASTLHSRLDGKKKIKGAILTPNEMEELTASWKPYRSLAVFYMWAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U2T5</accession>
    <name>A0AA38U2T5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_64749</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U2T5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="21">
        <location>
            <begin position="261"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="114"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3791068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="544" mass="62186" checksum="598498391DF3A0B0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U331</accession>
    <name>A0AA38U331_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_256720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U331"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3791233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="209" mass="23546" checksum="C189F10231FFC6EE" modified="2024-01-24" version="1">MPVGIEAWITQIPPITRGWLALSVLTSLAVQCQLVTPLQLYFSPKNAFINAQPWRAFTTFFYFGSISLDFVFHLFFFMRYSRMLEESSFANRKADYFWLLLLSSVMLLALSPLFNLPFLSSSLAFVPIYLWSRRHPDTPISLFGLFTITAPYLPIALVAFSWVLSGTWKAAAGDLAGCLVGHIGWFLRDVWAREMNGGTSVLSESPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7F4</accession>
    <name>A0AA38U7F4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_340366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7F4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="316"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="716" mass="77617" checksum="B3EBA74099F9F235" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7S9</accession>
    <name>A0AA38U7S9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_147445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7S9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="442" mass="45508" checksum="72C0CCDFF23B4E92" modified="2024-01-24" version="1">MTASEKYQATFYWPHTEPSVVIVTGSFDGWSQSLRLQKREDGFKGTAELDSNEKIAYKFVVDGQWLVNNQEPTETDNSGNVNNVYLTPEKLSEAPRTNGILEESKLSSENAVDLATIIAATDGTSSALGYVASGVGAAIQGVIGIDPINPDQMSVKSPVSPFPPTSIAVTAATEESNPTTASSDTAPSSMTNGAVEDISVPVESTETAHPPVEPSTHTPVNAAPLSPQVPSADSAPPAEAEVTPSTHTPVQASAALSTEPPVETIPATPIPSATIPASSSVEASTHGPVVVPASPTSTPDAVTPASTPAVNSVTPVPAAEAVVPSDTTSGDTKGAIPAEPTIPTTPTKKTHLNGNGNENASTPVGSPVGSPAPRASTSSILSTPSKRSSRILSFPSRGSPTPDSSPSSKFESPSTRAKRKSIFGKMSIKNLFGKEKEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7U4</accession>
    <name>A0AA38K7U4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4100 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_391054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793654">
        <property type="protein sequence ID" value="KAJ3780789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7U4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025165">
        <property type="entry name" value="DUF4100"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13352">
        <property type="entry name" value="DUF4100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4100" evidence="2">
        <location>
            <begin position="84"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="262" mass="29131" checksum="C352D252E0435556" modified="2024-01-24" version="1">MPTTRDNIQRNFNNVEDLARKLDALTLAVQNQRAPLRLNQGSDSTPARCFMCGQSGVHPLGIRFCPETNTLISECLLTFNAQRNRYVLPDGQDLPRVPFGWNGGVSSYLRQNRTGNMPIQDPPPHLPNTGAVSIVGLMYGDSEVLSGNAFALESLPFDEYHTNYYANPSLRSGKDTTNHFNPINRPEKDMERIPIRPVAPRPAPNPNSQLPPQTIQHPQIQPHKEVRFDTGPTPTPSKVNIPQPPNPINNEHGWKGSRPGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8H9</accession>
    <name>A0AA38K8H9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_364798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793504">
        <property type="protein sequence ID" value="KAJ3782034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8H9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041288302" evidence="1">
        <location>
            <begin position="30"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="231" mass="26418" checksum="8A82EC415C959424" modified="2024-01-24" version="1">MRLRPSITSHCILSAYLLSAALLSTVVVANPIPISSRTTDARDVRIRLAWRNPGEENFRSVSRKFTATDRFSLVMTEKSFSIGFEIQDSTSAKHTEIIKVDLPRMPSGRIIDAALKDLGAGNEHLIAHFIDLDFFNQHYAVIRNVDRLRTETNALLKKKAEEHKDFTIGDPEFQDPIDIIRDDLDWINTVLLYLTLINQPESGVPVLDPKELVEWTKIFKEMTSMRRQVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8Z5</accession>
    <name>A0AA38K8Z5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_273977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793430">
        <property type="protein sequence ID" value="KAJ3783219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8Z5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="62" mass="6438" checksum="8C1E10FCA8A29896" modified="2024-01-24" version="1" fragment="single">SSGDLDIARYLIDQKAEVDKVDGSGWSALHIAVSAGNDSVVEELVGAGADVNRKNDKGLTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K903</accession>
    <name>A0AA38K903_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NMDA receptor-regulated protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_389216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793427">
        <property type="protein sequence ID" value="KAJ3783279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K903"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="848"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="877" mass="98637" checksum="1F2B0D28069C4926" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9M6</accession>
    <name>A0AA38K9M6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_376660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793373">
        <property type="protein sequence ID" value="KAJ3784539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9M6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="243" mass="26932" checksum="3FB344FEB3F2CED5" modified="2024-01-24" version="1">MSSSPPPSIDAPLSLSQSQVLPMWRTLLVHVNRGTRSIKRDYQQQHRLITTNPTNGLPGISYARGTNAGHTESLSPTSHLRPRSLSQSSINSFAPSLASLAHSAWVFFSECEDDEGGEGGGERGEESEGEEEESRFEGGRPFNGEENVNVNVGYRRISPRRSLSTGVRLPNLNQTTHHPRITISSTQARWARYFLPLTRSVYWRSLIHLVLVNFPFALAAWVYLFVFTVTGTAFLIALPLGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBH2</accession>
    <name>A0AA38KBH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_165221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793886">
        <property type="protein sequence ID" value="KAJ3780148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="158" mass="17455" checksum="312FE7545A5C84FA" modified="2024-01-24" version="1">MQTTFSEPLPKPFSTAVAPDTATFELHRARRYTSSSTYTTSTKSSHSSLSSSFSSPYSWTGPGYGKSRNGDLLRPPPPLHRPTTFWRRTPRSGVTASSYSPASHLIRRSTFIAAGLPFEKPVADISALGVESRVKAQFDEDNARAKVSEVFWEVVVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCU0</accession>
    <name>A0AA38KCU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_389837</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="MU793474">
        <property type="protein sequence ID" value="KAJ3782473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCU0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041336959" description="laccase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="162"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="363"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3782473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="524" mass="55593" checksum="757D39DE37618474" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCY0</accession>
    <name>A0AA38KCY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_370122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794045">
        <property type="protein sequence ID" value="KAJ3779936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCY0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041225795" evidence="2">
        <location>
            <begin position="18"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="482" mass="49188" checksum="E85E5A38A6A9AAF7" modified="2024-01-24" version="1">MRPSVLIVLVLAAISTAAPLGELNRRSREDGLVKRVKFPKISIPKESPPKNEDPPPPPSPPKVAPPPKENPPPPPPPPPPPPPPPKVAPPPKENPPPPSSPDEKSKPKESPSSTTKPDTTSTPKPTSSHSKSSSKSAEPTSSKGENTSSSEKSETSSVKPTSHTGSESEASHTATSSSEAPKTTRPIGSETESKTATSTEAGEKTGTATTNTAEATITPAPDSGSSTDSDPLPVTTDKHHHVVSAVKEILTELINGQWQTIDTYAYPTATDSAYGSEDTGAPVDGSSPADTSSQEVPPDISSQEETGGPPEDGSSNGVPPDGTSSKDNLSTGTDQGSNSTSVDNQSGTDESSPDITSNDSASNSTSTTSSSDNASSDEPNSDDESDTDTDSEGSNDSVAGSGDDESSGTSLDNVSPTSNTSSPKEGSSAVNGGKTTTSDKSRTGASTGSNSSPSTQKASRSNYKRMLRRSSAARMGEDGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD73</accession>
    <name>A0AA38KD73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_296746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793438">
        <property type="protein sequence ID" value="KAJ3783058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD73"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041318183" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="218" mass="21905" checksum="946346E28EAD7558" modified="2024-01-24" version="1">MFAKVILLSALVSSAFATVFITTPTAASTFTAGQTATITWQDNNVSPLLAAWGNASVGIWAGNANQQTLLQLVTASVNVSTTTSIQFTPNASIGPNGLEYFIRMESLTLKDANNTQYPEMAFSALFTMASMTGTFNSSVSAEIAGQSTAPIGGSATGSVAATTSAASSSAKVAAASTTSSAKSTTASAASASNGALSSVVANVWISAIFGTVVLALMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD84</accession>
    <name>A0AA38KD84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793760">
        <property type="protein sequence ID" value="KAJ3780386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="268" mass="30815" checksum="1E85DD5F07F1378D" modified="2024-01-24" version="1">MTVNHIDWFQDVESTYYSDSSEDIPELVPISPSQERSNPDSESLTRRDEPSSWQSDGVEPVNWGSEDCYNSDSYNSDADPENSASGKRVRSGPDSEWEDSRHVLEEIRYGCSPLVLYSIQNSIHMRTIFALPRERHRRETDEDRGRGLHNEMNVSHFGFLTDPLQRKFGDPLAEQLEYLLTKSSPYPSEDGNEYMAVDRFFCEHVLIDSAGNDNEYVLNERILQNPDFRPVEWFLREQGLTLEDHPGTKCGSMGDPRGKRNQRKGITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD98</accession>
    <name>A0AA38KD98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_144891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793733">
        <property type="protein sequence ID" value="KAJ3780461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD98"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00034">
        <property type="entry name" value="Antisense to 5.8S rRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="53" mass="5831" checksum="05C146AA8744AC49" modified="2024-01-24" version="1">MPSGIPEGARCVQRFDDSLNSAIHITYRISLRSSSMGEPRDPLLKVVLSLMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDF9</accession>
    <name>A0AA38KDF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose-binding like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793667">
        <property type="protein sequence ID" value="KAJ3780716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041245340" description="Galactose-binding like protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46624" checksum="214C7F57CD983F9C" modified="2024-01-24" version="1">MKLVNFGLLVLPLALSIAGAPLPMTRDSEVVPADEDVADCHSLNNHPQYGIFYTGPGCPSSRPCQLTSAHWDNDFNPFNVWDSVTMDHNSDGESMGYDSVPSTELAIRLGSDLVLVSRDATKLQKTGNTLTKTGCALGKAAKGVDAVPEIGEIVGTAIQVVDTFLKLLGHIFSGIAEAERKSAHARGEFTQKVTDQTVKEHPGWLVVTVHPKHTIFFQGNEHTDWSHSTTSIKTVCHFLGSVRGHHLNFTTQVTGTYKFDVYAARAGIFSNDGDGGYQNWAPSQHIKLAGYENRRLVFTGGTPQNHPTSGKCMVHAYQYQKNYKKVNELDHYTIVAVVKDAKGVIVGFEGNGDGSKPVPVSSQLHDSLTIITGPNDKTPLSFSFNKDKWDSNTKLVFTLVTYYLRNTTTVEVVLDFSMKDPIKTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFB5</accession>
    <name>A0AA38KFB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_290284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="409"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1306"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="879"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1628"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="906"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1660" mass="186767" checksum="0D3191C7347CE6CE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFF3</accession>
    <name>A0AA38KFF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_394550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="230" mass="25346" checksum="376001A6F5494791" modified="2024-01-24" version="1">MSRWIPLESNPEWANKAGLDKEESQFSDIYGLDEELLAMVPKPVRAVLLLFPISKTLEAKRREEDEKIRSESIPSSFSSIIWIKQTISNACGTIGLLHALANTGVKYTPQSPLAQFIEACRDKTPAERAQFLETTPLFAEIHAESASTGQSAVPIDLDTDLHFTCFVEADIEGVPHVVELDGRRAGIMDRGKILDDLLTDVASLVKETYIKSSGGSIQFSMTSLGPPPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFH9</accession>
    <name>A0AA38KFH9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_334182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFH9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041259006" evidence="2">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="261" mass="27217" checksum="FF7419F6A8538E29" modified="2024-01-24" version="1">MKLSTFFVSSALLFSVVVARPSRLAERVAARESRRSRPFTASTSNTVLAGNVSHAEFSENWSGVVIESPPSGQTFNKVVGTFVVPTPTGNSGAASAWVGIDGDTASQSILQSGVDFTVSGGRVSYDAWFEWFPNFATDFSNFAISSGNTITVTVQSTSSTRGTVTLTNESTGKTVTQALSAPDSAAALRGLNAEWIVEDFEEGNSLVPFANFGTVEFTGAAASTSSETLTPASGVILDIEQNGEVLTSVTSSGSTVTVKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFK2</accession>
    <name>A0AA38KFK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_435405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793384">
        <property type="protein sequence ID" value="KAJ3784256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFK2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="580" mass="64295" checksum="E9ABA4FBA4AD34B9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFV6</accession>
    <name>A0AA38KFV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_151503</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFV6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3787258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="369" mass="41247" checksum="6884E16178ED7570" modified="2024-01-24" version="1">MDVGKKFTTASRSLSSSSLKDRLSKLSVTPLKPITIHSNIEFAPARIPRKRRMQMLAVAAWSVAIALATVLFLFLCSIPALWPFLAAYEIWITWIDQSPEHGGKTSQWFRELGFWKYFADYYPASFLKEAELPPDRPYVFGYHPHGIIGMGALATFATEATGFSAAFPGIKPHLLTLASNFRMPFYRDIILAMGVCSVSKKSCSNILKSGPGSAITIVVGGAAESLSAHPGTADLTLRKRLGFIKIAIQHGADLVPVFSFGENDIYEQMPNQQGTTIHTLQKKFQSVFGFTLPLFHGRGLLNYNIGLMPYRRQIVAVIGKPIHVEQCDKPAIQEVMRVQQMYIEELTRIWNAYKDQFAKARTRELSIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFW0</accession>
    <name>A0AA38KFW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="356" mass="40094" checksum="816EA3BF31933E09" modified="2024-01-24" version="1">MDGDYLSESSYQATAYLRIASVSIALYDFLETAPSTWRYTREQWNAPRMTVSFTLFLLIQFTSIATLVLSNVGYFYSHFTERSCSRYYIIPSVFKVIQSTVSQTILGLRAFNLSRRSRLVGLSLLILLIAAAALEGLTNLYHRTAVLDSQFGNCRGVFQIEHLGAWIYYVVAIIYDLATSTICMIYLYKYKAASNSFFAKVTRMMFYDGVGYFTALTCVNILNLVIYRASQEIQTAAASLGYCVTWIMSKRLIIHLHEVSMKRRIDTVANAATSSSQSTSSEFSSSHEVRTHVKANSPTASLDLTIPDFDMEDMEAGLDWAEDGNVSHVRSEKTVQVERRPRAVYELGDDSGCLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG95</accession>
    <name>A0AA38KG95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF1212-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_395164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG95"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="8">
        <location>
            <begin position="395"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54350" checksum="E4DC2C5A9015CE35" modified="2024-01-24" version="1">MSSVLQHARRPSVITQHIQDIKIRQKFLLKLSKALLSFGAPSHRITSQLTAAANILGAEAEFVHLPNIIIASIKSNPNSPSARTYFVRATGRVALTSLHQVHLVYRDVLHDRIGAEEGTQALKKLLREHPIYPLYFRCILAFFAASVICATSFGGSFLDMWVSGFCACILQYLGLNAAHKSAMYANVYEISVSIIVAFVARGLSNIPGNWFCYGAVSSAGVVLILPGFTVLVSALELMSKNLFCGSVRIVYAVIYTLFLGFGLTIGSDFYLVVDRRARKAYYANSIPTNLTYTHGRFVMANGSHPFVPIQGVLGQADALNYEQQHLVKGCYRDPSWQWFKQPFPWWTLLILVPLYSTLSSLGNLQRFRSVQLPVMVLFSCCSYAANKGASVVLPGRTDIVSAVGAFVIGLLGNLYSRVIGGTAFTSMVTGVLFLVPSGIAQGGGITQTYRNSADQYSSGFSLALRMISVASGVTIGLFVSQLLVYLFGSRKNAAHFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGF3</accession>
    <name>A0AA38KGF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GATA type transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_286877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="205"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="415" mass="45304" checksum="0D435B44153CBB0B" modified="2024-01-24" version="1">MLSDMDALSFDGYTSYSDSSAPRTPSPRADLPYPSPTHIYDDELNAGAPSGYRGSLLQELYGHEEGYSKQQQHQQQQQQQQHSQMPPTSSHPTIPRRATFPYVRHDAPSYPPSYDGYEESYAVVPSHGPSGPQAYYQPPPHNPYLQQSPHHHPYGPPSSGMLPAPAMAMGGMPGMPMGPYGHLQPALPIQHTDDAASKETQYLRRRCFNCHTTEPPSWRRSTLNPGKIVCNKCGLYERTHLRPRPLRFDELRAGGKSRKNSLSNGSTGGNGKTSPKSPGKSLVKKESVDVGLGRIRGNRRSSVSSSAGSGSDWDDNAQPPQLYPTQPEVQYSYDSSFAPTSGYVTSSPPADSPTFGPSAELYGSPYNQGSPYHQQSASPYHHSHSSASPPDTTHHSLTLPPIIPEEATPTKRASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGH6</accession>
    <name>A0AA38KGH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_427734</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793329">
        <property type="protein sequence ID" value="KAJ3785891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGH6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3785891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="136" mass="15429" checksum="13B9B4D93659BD4D" modified="2024-01-24" version="1">MMRTALTTALRAAARPSVAARSTPIFVRFAHAHAQESFEQFSARYVSFFQNAEDLFELQRGLNNCFAHDLVPSPEVIEAAVKAARRVNDYSTAVRIFEGIKEKVENKTQYETYLTELKGLREELGIALREEMYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHF5</accession>
    <name>A0AA38KHF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_264864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="388" mass="41376" checksum="53D5CAE0A7BFDF0E" modified="2024-01-24" version="1">MNPSSPNSGAPSPVSDDSSTHPHSPASSGDNSQINSKTTGVKRKATRRASTAERRATHNAVERARRETLNGRFLDLAALLPNLSQLRRPSKSAIVNSSIAHIHAARRHRLLASRELRLLKLESDALRRELNEWRSRAGIPRIDEPVRGEGFSVVLSGEPEIIPIPGGPGLQEDGDEDGFGEEMEDDYRPMTDTPMHSDDEVRVALLKSQSQSQGSFVSTINTNVHPMMPPSSMHAHPRAHPMGSSAGGPMIASPTNMSFENPMVGRVYDSVPYHTGDAYSAGAYGPAQDKWGPVGGYGYGNINDQAYLKSLAQNKRSRSSSQSSGSASPSSGYYEQAGWNGNGMRNGGNINNGMNMTMGMHNGDMGNIGMVGGGGSTMGNGGVAFAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHG9</accession>
    <name>A0AA38KHG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_141366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHG9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="237" mass="26322" checksum="D9B770D050ED05F6" modified="2024-01-24" version="1">MLVTNEIWSVVELAFGPNRDCCASILCILILLMELPSLEAIRSSSSNESPLAFTLASLLEPSSVLLHTLVPQLYAKLKNSSSLVKSYTQLIDLAIEQVRTWDQNLQAQVISGHPRIGETKNLSTFSAKEQGANHRHPTATPTPPDILARLAHLNAYYERRYPKLVYIVFVNGRSREEIVRVLEDHLGLEHSLSIDEPPLDAAVPVEIESQKWLDELERAVEAVGLIAKSRLVALGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI82</accession>
    <name>A0AA38KI82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_344458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI82"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="552" mass="61383" checksum="684AD64BBF6C65E8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKQ9</accession>
    <name>A0AA38KKQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794099">
        <property type="protein sequence ID" value="KAJ3779880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKQ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="68" mass="8282" checksum="EE640325F171D33F" modified="2024-01-24" version="1">MSSAEKANAQERKKEENANYYLNHREDILDKKMRQRTQSYIAKYGGYSFFDRYPHKSIKYQKYLPEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL91</accession>
    <name>A0AA38KL91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10e/L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_279238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793713">
        <property type="protein sequence ID" value="KAJ3780525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL91"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24895" checksum="A27AD1E5D93AB254" modified="2024-01-24" version="1">MGRRPARCYRYCKNKPYPKSRYNRGVPDPKIRIFDLGRKRANVDEFPFCCHLVSDEYEQLSSEALEAARICANKYVTKTSGKDSFHLRVRVHPFHVIRINKMLSCAGADRLQTGMRGAWGKPYGTVARVNIGQIILSIRCKEQNAPVIMEALRRARYKFPGRQKIIVSKKWGFTNVNKEDYLQLKADKKVVQDGAYVQFIKSKGPLEQNLRNSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLI2</accession>
    <name>A0AA38KLI2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_98188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793532">
        <property type="protein sequence ID" value="KAJ3781694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1503"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1515"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1592"/>
            <end position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1610" mass="179780" checksum="167DBAD4BBFC5C4E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLR8</accession>
    <name>A0AA38KLR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_298590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793505">
        <property type="protein sequence ID" value="KAJ3782024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLR8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="37202" checksum="9145CF43FC76837E" modified="2024-01-24" version="1">MPVDVEEDEPDVQLGVEDTELNELGDSEFPLYFTERNNRLYQADTAASPYPLPVDTPENQRVNALHKALYQLIGRANYIGPVAEVLAPQEGPRKIAIDLGCGTGQWVMEMAREFPHVFFFGLDVVPIATRYPEDNVQFELHDIGEPMRWPNGSVDLIHARSIFMTVRDYSVIISEAARLLKSGGMFLSGEWGPFPAFHPTFPQAMGDPRDYVPGLDRFYRLLHSVLATRGIIHAVASTVHQRLDISGAFTDIHEHIFYMPIGTWSPDPGTQILGKRNRAALTKFMNSIRPIFVAAGESEADLEQLYNECWTEMYGASGLVSVYYLVPARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM96</accession>
    <name>A0AA38KM96_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_233066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793451">
        <property type="protein sequence ID" value="KAJ3782819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM96"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="53" mass="5742" checksum="7C206FEAD1F865B6" modified="2024-01-24" version="1" fragment="single">SKLPLDWPSPLHNKCNKSSCYYPNLPQPAPGTYICVGCGQGKYVVTLEMAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMK0</accession>
    <name>A0AA38KMK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_405228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793432">
        <property type="protein sequence ID" value="KAJ3783179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMK0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="432" mass="48143" checksum="47AB930F93AE423F" modified="2024-01-24" version="1">MKSQRIAIAGGTGRIGRHIVESLLDIKHQYSLKIIVLSRSQAPNISYAGTSAPVLPIDYQELSSIQKTLNDFQIDTVISTLLALPPTRSLLRRKTSSARRYQYLQFADLLPVDFLEHSVSVSGETGWATQSPLNDETTIVSPISHQHAPHKFPPPSTAHIDLQTNIYSTQLDEDLKSGDVFKFYLLAKTIREVDAVYLSPLYYQLDTSNATLRYGLLSWIAEESLAGDIDAAEWVLLSSNNLDIHPSCPRPSLYPTFLVSRSAPSLSTAPLEPSMTLNTSTLYPNVLSLILPIIMHVPLSLPLLNDGVSEGAKDDPEDDVTEGEINDRSIRNLRALQEVIHHQPLEYVFPYSGFRFEIDTGFIVCTEGKKSVLAETHITIPLKPAKSWTSAELQQRLYKPSTEIQLPPSNKLEAWWKLVGGAITKRQTIFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNT4</accession>
    <name>A0AA38KNT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_26977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793373">
        <property type="protein sequence ID" value="KAJ3784514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="674" mass="77500" checksum="BF077F847FD480EA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNY2</accession>
    <name>A0AA38KNY2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2R-phospho-3-sulfolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_277887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793583">
        <property type="protein sequence ID" value="KAJ3781251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNY2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="333" mass="36423" checksum="8A2F4613E349AB23" modified="2024-01-24" version="1">MLRGTWTSHSRRAFSSSCHRPISSSSNTPTSAYNFLPSNFLPAKPRSHGLTEIRGPYYYPVTQTYLDELLSDWGEFVDGVKFAGGAFSLMPEERLRGLIKTAHKHNVYVSTGGYIEKVLSSSNGNRAVIQKYLETCKNTGFDVLEISSGFLSIPTDDWADLVEMTAKAGLKPKPEVGIQWGAGGDASVAELESAGTRDPKWLIDRAKTFLEAGSYMIMIESEGITENVRSWRTDVISSVTSALPKDKIMRAFPNSLFVHLAKLSVNRFEAADPEVFAYHIQNQGATANLFVDHSQIVQLACLRKGIWGTGSTFGKIVTIGEGESGGSNRIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ13</accession>
    <name>A0AA38KQ13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_13027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3785010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ13"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="89990" checksum="47D40A13393DC87E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ49</accession>
    <name>A0AA38KQ49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_313593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39506" checksum="B3DC13F2376BCAF6" modified="2024-01-24" version="1">MDQVIANLFALLRQLKPLPHVLQADLTGKVVVVTGANTGLGFEAAKHFAQMNPKKVILACRSEEKGEQAVQKIVRTGYMRAEVWLLDLSSFDSVQAFADRFEKEGGGRLDILVENAAVAPLESYQKTKDGYMTTIQVNALAPSFHSLLMLPHMIRTAQEHPETNPRIVFVSSGLHESSTLSTDISREILAKPNFIDALSSLEYFNQMWSAVHTDNSSVLNIFFARALQTRLSKFCPIVVNSVDPGYCISDLRRSIVSGPRGWLFWLMDRLVAYSSEEGSRSLIHAALAGSKATIGASEDETKYKGAYLSTQNIASVSKFARSEAGLRLQETFWDDMVQIASERDERVARFVKTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ81</accession>
    <name>A0AA38KQ81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_420189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ81"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="34791" checksum="BA818B1E6FA1013E" modified="2024-01-24" version="1">MNSAYIGQFQSDPFIQYGSTKLGGCHQPHFVTPFHQYNPSNDEHVFNSKNPKNPNAILDSSQYSKAPTRYTQKRTAAVDALTQVVLAQPPDLPRWHPRAQIHASFHPSRNILQSEYSSYPLAEVENAQISTQILPSHQTSTTALAPNIGNTRSGVIVAAPVPQKMVASSETVLHALNNVGNQSVAQGLSLQGGNQPRQPKNNRLPAPSSKSQHGAKENPGHPLCVQDVHSPRSSSDIQERRTQSNFDEIVIADTDLNSAVERRDPLLSSSTSKNGKFNSEPLRSITPTTMIALTEPILMSWCFDDVAVQRLAKAAGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQA7</accession>
    <name>A0AA38KQA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_355162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQA7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="88" mass="10032" checksum="E7281455D68824FD" modified="2024-01-24" version="1">MYYTYLARRKTLFAWLAIQGGLATFVTSQYLKPKSQLSALGRVYRLQQQNAQEHLPEMPALHDLVAPLRPASHSHKLHARLCACNILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRZ1</accession>
    <name>A0AA38KRZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="481" mass="51700" checksum="55566D7EA1D0008C" modified="2024-01-24" version="1">MSSVVAQEETSQPSGTISTQGEKVSRDSTGSNQIGNSADGEIFTKATATPEQSIASINNTASTSKHLDPSPALPLANPRKQKSTGILSLRRSPSGSRKRSESLSASAPKSELIPPLPTKKEPEQPPKSILTPSSSSSSLSHPATPSPSLSRSPSIQFAPLPQLAPRKRKSSVPLGIAARSAMMQRRRQIMYGSSTAVNLQNPKDAADTSSVEGRGMWTPAEAEEHMTRQLRSKEKERDRMLKKQQRELEKDATKSASRSRHGFNDEAEMGHDDPLVVFGRLMKDAWRRVGKKDGNVKADLPAKAQIGSNVNSADTTTKAPSASEKPVESVAKLDQTAFKEADNDNRFVNHESDSPDEYNDDEIDLDPNEVDVSKIATLRAGSPPPSHNHLSSQSQSETSSIAGSDETVGSDSTMTSPSPTSPPSPTTPTAHTHTHISTDSSTLERTLSKNGTRNSVTIEPERSVHRLPSLELTPLSPFLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSM9</accession>
    <name>A0AA38KSM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_347071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSM9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="13">
        <location>
            <begin position="281"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3788130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="644" mass="71099" checksum="9485CAF5C8AFDE2B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSQ5</accession>
    <name>A0AA38KSQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_119457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSQ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="82"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="777" mass="87107" checksum="454E7C8DB34BBDA6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTL0</accession>
    <name>A0AA38KTL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793678">
        <property type="protein sequence ID" value="KAJ3780657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTL0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="265" mass="30159" checksum="26F4F13D61D201FF" modified="2024-01-24" version="1" fragment="single">SETVAERLETSHLRAAELEATIKRVEGERDDLKKNLTILEKAPRNTPGQQSEVSARSAALEAQVQALDSTVRRVTAERDTLENDVLASEEQVRKLQTLNETLQEDHSQVVTSRDTLVHENRALLAMNQVLSDSFTNLETEQEGRVSRVCLLPVTSFLKETQSVQSRFERLQQNHDRVMTKLQNAQQEAEARTTAERMNSNGINEELRELREEHARTVRKLAATKSREAELEKECDDAANRAVELEKQNDKSKEECNTLNRMNVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU03</accession>
    <name>A0AA38KU03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_385540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="130" mass="13711" checksum="43D2CAC520CBFDA2" modified="2024-01-24" version="1">MAAGLKTVILLSFVLAVGFLLIILSCALWQNWLPLLVAITFVIAPLPNALFSHCGADDFSGSFEPTGPVDLGRFLTSLIVVTGFAFPIVLAHSGVINTSACVMSIVGGGLVYGTILAYSQAFKQDESDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVF1</accession>
    <name>A0AA38KVF1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Interferon-inducible GTPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_295003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793394">
        <property type="protein sequence ID" value="KAJ3784002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVF1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="6">
        <location>
            <begin position="121"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="40209" checksum="ED31F5BECE03ECD3" modified="2024-01-24" version="1" fragment="single">MDEAEFRAENERRARDEAEIERKHAILSAEEFRDRERSARDAAVKAEEAREKFERLEERARLTREETEGKLKTLKEDGEKTEKELAKARRREAQLADLQPVHEPTRAEHEQTKRDRQYIEGRLHLAIAGMAGSGKSSLINAFRGVSKGTASAAATGVVETTRVIGRYEDPHPDRSKFVWYDIPGAGTTNVSNSNYFITQGLYIFDAIITLFDSRFVDTDITILENCKKFNIPAFIVRSKSDEHIKAIADEMREALDEDESEDEDDVRSKDREARRTRIDADAREEYISVTRRNVKENLQNAGLDDQQRVYLISRRTLLRIVRGKHVAPTKLIDEYELIKDVMAAIKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVH3</accession>
    <name>A0AA38KVH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_35019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="107"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="570" mass="61485" checksum="4D54D3B58DD004A8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWR4</accession>
    <name>A0AA38KWR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_391059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793655">
        <property type="protein sequence ID" value="KAJ3780788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="718" mass="80425" checksum="9D1915E2FBB12ED4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWW7</accession>
    <name>A0AA38KWW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_379891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793604">
        <property type="protein sequence ID" value="KAJ3781103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWW7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="182"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="378" mass="41736" checksum="D619FEBA552E5EE8" modified="2024-01-24" version="1">MNADRFTLPSSSSSNLRKIHRAAVRVENDVAKPDLSIRPTLSSESESPTKVARVAYATFATRFLVNIFFFIPKSIWSIVSGFVIAVPIVAGLIGKLTPIPLRSRFFGMFGRILCYVMQGFCVIQSFILPEPSMDCKMSAERNHVLWDAPIHLAQKPINSLPGDLASPLPDYIRLNYALADNGAKVIAALTSLTAGLKQSSFVDNLLILARGFDKNQMHVNPPRVVLEDHSVSDCWKFEGSHGHLAVSLTDTIHWHGFTLDLPDQLMLSEDTLRQAPKELALWALVSKDEMDIGAPSLFSDWKSFLVVGQLLDPSIFNSSVVFQLVAKVSFDVLNGGQGFSTQFVAQTSVILVEVLDNWGNDFTCLHSILIHGERVQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYI0</accession>
    <name>A0AA38KYI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="16">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_273449</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="MU793417">
        <property type="protein sequence ID" value="KAJ3783473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYI0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 16 18" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3783473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="355" mass="39939" checksum="650C763333E2EBF9" modified="2024-01-24" version="1">MSPNLSFIAAPMVNQSDFPFRRLTARYGATTVYTQMLSPELLIHDQEYLEFHRRDLQSINEKPVSTVVQLCGNNAEEIIEAGRKIQDLCDAIGAKLDLNLGCPQEVARDGHFGAYLLGQKDWPVVENIVSCMAQSFRVPVSTKLRLCQPSSKTVELAERLEASGSSWITLHARTVSSRRRRQGAADLSEIKRLKQSESLTIPVVSNGNVRVFNDLAQNLEYTGADGLMVGETLLGNPCIFSNNILPDPVEISLEYLNICRLYPGVATLKTIQTHIRHFIDFQCARRPWSRKLRAALNACTDLDDIERLLRVKIQRWRGMTIKSFTETDSEDEQDFDNGVGNIEDAISWHLSGMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZK6</accession>
    <name>A0AA38KZK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_188395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015318">
        <property type="entry name" value="Znf_GAGA-bd_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09237">
        <property type="entry name" value="GAGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="242" mass="26843" checksum="E868B058B3AECC8B" modified="2024-01-24" version="1">MPRARSLKNGQLSEAYNPATCSICNAVISNKTDLPRHMKIHSMDREKLMHRCPYPDCNFENLQKSNVETHIRTHTKSKTSCCPDCDFTTVDPGSLTRHRKRIHGYIPKMRRSRHPKPESEPGDTPGADVQSKPLTLRFSPYSVAQNQQTELSHNRDSQSSTSTSPPSIADMLNEALPDYSSRSPTQSQPPPHSRSSSPTAMAGPSYSFVLERQTSQFSQPRPPSPPIDPTLLNAGPPRAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1L0</accession>
    <name>A0AA38L1L0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794094">
        <property type="protein sequence ID" value="KAJ3779887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1L0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="83" mass="9952" checksum="AE4A6C42B9E1D7D7" modified="2024-01-24" version="1">MPRKRTQSAILKSERTPEQKQAVNARSRRLADRRYRRQLKYHNPSNAKEHMAKKRAEMTDEEKQAAKEKKKRENAAHYLKYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L376</accession>
    <name>A0AA38L376_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_60690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793434">
        <property type="protein sequence ID" value="KAJ3783157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L376"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="63"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="511" mass="56642" checksum="C527CF39F8D7DBEB" modified="2024-01-24" version="1">MSTSFKDDVLEDDKNDNIEYIENAELKPVATLRLDKHGVPLSPQPSDDPEDPLNWPGLYRAFILLQVSVLSALGTYNTAIINPAYNQLSAEFDVSIVTASYQTTVTIAVNGLGPFLFIPFAHVYGRRPVYLVTTLIGVLSALGCAYAHNFGQLVGLRILNGIFPVGAALGVATANDLFCLHERGRALGIYTVLSTTGGHFAPIPGGLIGQYLGWQWIFKFAAITNSFCLLFTFFFLPETLYIRDRTRDIVEDSNSNSKSSVRRYLRRMNLGKRYPGRELHISDFFWPYIKMIRYPSVVFPAIYYATQYALGSTLPAVTVSHIFAQEFSWDTLQIGLAYGTALLIGAFLGETAGGWVVDSIMNRARVKALKGSSAPSEIRLRAIWTGEIIVPIGLLWYGFSIQFRAPWIVPILGMGVGCFGVQCITTVMYTYSTDCHLTKSAEVAQVFNFVRQEIGMTFAFYAIVLGEAMGGYHLLFVFFACVGSILAFIPILVLMWKGEAIRAAERRIFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3J1</accession>
    <name>A0AA38L3J1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3J1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="316" mass="34695" checksum="0F241CACAEC9F8FF" modified="2024-01-24" version="1">MLESTRVSRAQDKDFPIEPSFVNAPDTEIVKTDPKDSGKPQHVSETVIMSDKAVDWDPKLLPQADIPIKRVLQNKIGQARKFSGASRKRLQRSSTVQVRYKPYSKQVPSCSSYSNFNNNNVVDSERKSDTPHDYLDDRLNDAHVRRLGKMDLAQSRNNPPSLPHQWESPPPPRTTPLAADPGKALLKQPSSDQDVPEGGDGDKASEVPNSPSSGSSPLGQAKSGSPKASQTQNVPADVGSVQLLVEAPPGCNNPIILNFQMHNTTHIAYNFNNAQGDVNHTTNNDGSSYQFKAWVLVICSTPTDVRVTNMYLVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L458</accession>
    <name>A0AA38L458_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793361">
        <property type="protein sequence ID" value="KAJ3784867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L458"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="282" mass="30794" checksum="487486D6E25C3553" modified="2024-01-24" version="1">MLFQSASNGESMNIKHYSLLLSTDSSLSISSGLLSPLAGLDILQGFEEGHISPTLISSGPPSPLLGFNLPNFGENQHTISSGCLSPLYGLSSLRTFGPAPTSSDIISVSSEAIAIGDDHNRSAIHKAILNTSKMADQYTVTSGGQFTSHNDRNTYPGHFIHRNVMDKKTNNRDHAEDQAQAPPAHSHSHLPEPDVLSCWETGPFSFIACGLPSDVDRDQELSRSEIGSCRIPDRESDPVISNSNRYRWHGQRSICAPMPLCPLQQVLREMEELEKMVEDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L583</accession>
    <name>A0AA38L583_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">X-domain of DnaJ-containing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_161454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L583"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="490" mass="54300" checksum="F65D094F69E5E430" modified="2024-01-24" version="1">MAPVETEYYDLLGVPVDADDNQLKKGYRKAAMKYHPDKNHSADAEEKFKDISKAYQVLADPNLRAVYDKNGKAMTDKEGGLSMDDAAGFFANVFGGERFHDYIGEISIMKDMTEAASTMMTDEEKAEIEKQLNPDKPSTPPVTGEQTSAIQHDDSHNSSAVNPSSEAPGASPSSRPEATTQPSGSSSLVVHGEHVESTSRSPSNSINEKEKLEKEREAVRKRKAEQKEKLREQEKERRKVMEARVSMLTTKMIDRLRPFVDAKHPGDKDDPETLAFEAKMKREVEDLKLESFGVELLHTIGNVYMMKATSFLKSRKFLGIPGFFSRLKEKGTLAKDVWGVIGSALSVRDTMLEMEKLQAKGDVDEAELKALEMDVTGKIMLASWRGARLEVIQVLREVVDNVLKEPGASETVLFNRAKGLMLMGAIFKAAEPDESDEERRELERMVAEAAQPKPKPKGGKGKDPRHAPHAKETLEQKSPTPEPTATAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5Q5</accession>
    <name>A0AA38L5Q5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_137436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5Q5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="235"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="235"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="597"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="736"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="774" mass="84458" checksum="3997D1D5E1A6BAD1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5T2</accession>
    <name>A0AA38L5T2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_308273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5T2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="323" mass="36212" checksum="A679E338AA097337" modified="2024-01-24" version="1">MSSDFRTLFDPQTCIRKGLCPITDIRNKGNPLESHSLYFEQHGSGPEKIIFIMGLNSSSFAWLPQVKHLSRIPEYSVLVFDNRGVGNSGTPKGPYTTSGMAEDAIALLDYLGFTEPRSIHVVGLSLGGMISQELAFRIPERIISLTLGVTTAGGHIWNNFPPWKGFNALTRMMFIKDPSQKIPILLDLLYTSPWIDEKAADDPKGRTNREVEFESYARRLEITRPQTLVGALSQMCAGLTHHVSAQRLRHISKSIPKVTIATGDHDHLVSPHNTVYLKTHMEEAEVVIFKDTGHALHYQRPREVNAMLERVFKEGRERVGAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L689</accession>
    <name>A0AA38L689_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_266200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L689"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="321" mass="36302" checksum="CE25D5121B24AA2F" modified="2024-01-24" version="1">MRSQRIAVAGGTGKIGRHIVEGLLEAKHRHSFEIIVLSRSQSPDISYAGFNAPVIPVDYQDQSSLQKVLNEFQIDTIISTLAGRPAELVYITSQENLLRAALSVPSFRRFAPSEFAIESEQISASVNLYQNKLPIIQSLRQVKQKRPDSFEFSLFECGVFMNYLGFGNTRPEGHKAHGHLAHFPYIFDLSKRSADIPGDGEKEIWYTRAEDVGKFVAEATQLETWEEYNNMAGEILTMNEVVRLCEDVCGTEFNVKYNSREELAARISPAPEKARANFFVESLIAIIDGECDIKRPMNLNKLVNVQPMGVRQYLEQWWGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBR8</accession>
    <name>A0AA38NBR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_365230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793514">
        <property type="protein sequence ID" value="KAJ3781906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBR8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="597"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="895" mass="98148" checksum="576E6E2CC7A7D605" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC02</accession>
    <name>A0AA38NC02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_363622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793471">
        <property type="protein sequence ID" value="KAJ3782521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC02"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="319" mass="35233" checksum="0A61288648614ED1" modified="2024-01-24" version="1">MFFSWKVITEDELVDLHGKVAIVTGGSTGIGYATIEFLAQKGARVYMGSRNQGRAQKSIEEIEAKLQKSGNDNQASIHWLQLDLLDPRSVKEAATKFIAKEKRLDILVNNACHHSVGPYKLNQDGLLDVMVVNHISPFVLTETLLSLLRQTATLEDSDVRIVNVSSGAHTFVATESFVGKENLNKQFGDSLSGYIATCGYSKLANILHIKHLQTRLNAESAPITCLALHPGTVMTEGASGFLNSVPFLGWFLKRFMGPLFFMSWKQGAGTSAFAAAGKAVAEARKSKDEVERRKYEDERLQRELYETTMEVLGEMGIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC05</accession>
    <name>A0AA38NC05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_436580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793469">
        <property type="protein sequence ID" value="KAJ3782551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC05"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="41919" checksum="EE10456549639A9C" modified="2024-01-24" version="1">MPPTYTCLIRRRFATLFVPPHCVKNEKQPKMNNPTGTEDFSLETKLRADSYLYLFAFTFLYYDHLLTFDDEVRFIWSRPNHFSSRLFFLNRYFSFVGNIVILLSMFFAPSSPSSCHPWEEFQQFFHAFVQVIVAILLTMRIYALYGRDRRVAVTLSGIIVFGVGATVISLAFSESSIATSLFPIGCHDALDLKNAALVSVGWELVFIYDTLLFSLTFFKAYQARFQPRVRELEKVSVFTIIVRDGKFHYPGNNTNIMALANFINVLTFYVSGNSLLRGTLSPFASCTSVSLMSRLMLHLHKIAGQGLYACHGDTIARPAHSYTPDVTMSVIAFGPKDNHPLSLDHSGDITDLELGSITHQGSSGTPGSSSATGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCV4</accession>
    <name>A0AA38NCV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_399121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793351">
        <property type="protein sequence ID" value="KAJ3785176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="549" mass="59640" checksum="20D8243FBCA3BBE4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCX9</accession>
    <name>A0AA38NCX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_398588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="MU793343">
        <property type="protein sequence ID" value="KAJ3785416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="1971"/>
            <end position="2188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2307"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2775"/>
            <end position="2800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2778"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="3053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="3053" mass="347884" checksum="F9821540E01ED2E7" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND65</accession>
    <name>A0AA38ND65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_267608</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND65"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041284835" description="glucan endo-1,3-beta-D-glucosidase" evidence="21">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3786226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="350" mass="37746" checksum="96A2D9801DD5B0C6" modified="2024-01-24" version="1">MWGLVIIGLLAVSGIVVGVVLSQVQKGSSSSSNLAITGDPSQFSKDSRLKQSFYGIAYTPQDSIYPNCNIQIADVVTDMQLLSQLTSRIRVYGSDCNTTAMVLEAIQLTKVNMTVFIANYPDATDNGVAYNRQKSAIESAIQAYGTDHIGGVTVGNEFILDYLDANGATDPNGSVGNQGAAILTPLIDDTKSMLQSLGVSLKVGNADAGSFFNDKVLADVDYGMANVHPWFANVSIDAAAGWTWDFFEGTDVALAQNLSNKPDMSIAETGWPTNSSDAGNESNGPSIASEANLQKFIDTFVCQANANGTEYFFFEYFDEPWKTQQFGGVEGYWGLFYSNRTLKNIEFPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NE99</accession>
    <name>A0AA38NE99_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_384556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3789001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NE99"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="574" mass="64395" checksum="DF2EC961251C6B04" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHL4</accession>
    <name>A0AA38NHL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_320775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793600">
        <property type="protein sequence ID" value="KAJ3781127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="520" mass="58977" checksum="EFB9B6376E0AF308" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ01</accession>
    <name>A0AA38NJ01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAIB/BAIF family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_388002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ01"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="455" mass="49476" checksum="CEAF7DFB8C889032" modified="2024-01-24" version="1">MSFVNGNVKLRRFNTSQASYNGVQELRGIPSPLAGIKIVDLTRVLAGPTATMLLADLGADVIKIEHVGKGDDTRSWYPPSAPLLPQSSSESLPERAHSLPPESAYFLSANRNKRSVTINFKDPAGLKIIYKLIEQADILVENYIPGKLAKLGLGWEKCHKINPRLIYASITGYGQTGPYRQHAGYDVIVEGEAGLMHITGEPYPAKPVKVGVAATDVATGLYAHGAIMAALIGRERTGKGCWIDCNLFETQIAGLANIASSYLIAGQEAQRFGTAHPSVVPYQVFPCKASEGQDGDDFIMIGAGNDNQFNTLCNLVLPLPSLPSDPRFSTNALRVANRNELIKILEIELRKETKAHWLTKFKAATKAGKGVPHGPINNIKETFEHEQAVARKVTVEVDHPRAGPIKLVAPAVSYNGEKMPVKRHPPWLGEHSDEVLAELGYSTTQVEELRARGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJA3</accession>
    <name>A0AA38NJA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_367598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793592">
        <property type="protein sequence ID" value="KAJ3781173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJA3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="176"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="339" mass="37399" checksum="37A6D07CF10C556B" modified="2024-01-24" version="1">MAQSIVTVSPAVTIDNTLGALFVGFTVACCVYGILLSQIYTYLTHYPMDRSIYKLIVLLILTLETVDQALIGQIYYHYGISNFSNSLTLIEGAQTWSFILQQTLGSVVGAIVKIAFALRVWRFSQRNFWITGLIMILTLGGLSLALVFTIKSFMLPDVFSVVKLRVLGTISLGVGVLTDIITASSLCYFLNKLRTGYRQSDSLVSTLIKYAINTGALTSVVSITTVILYNIMPNNLIFIGVFFILSKLYAISFMATLNTRRVIRGKGTDRQNTTANHTNIFHLGTRVPSMGPSDMAGWETAYTATSATQQEFDQQRPIIPLNTTGFQDPTLGKSYPNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJC2</accession>
    <name>A0AA38NJC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJC2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="186" mass="21188" checksum="FA3E4F3EA49E82A6" modified="2024-01-24" version="1">MFNFGKSKLPANWPPLHHKCSRSKCTFPNNPQPAPGTYQCRGCDKGTYIVSLAQAKEADARNRTMFYIPGRSPPPNVRPQQQTWDLNQEFPPYVQFEGRKQNHHSRANARPTANTVVRTPKPHSQGIRDPHAVYPQNTNRDIRPQMYSSYTLASTASSHDSAPRRGLPVAERAERKQVRPYRVVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJR3</accession>
    <name>A0AA38NJR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_93240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793515">
        <property type="protein sequence ID" value="KAJ3781893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJR3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="455" mass="51557" checksum="05495FB558F01547" modified="2024-01-24" version="1">MACYDILADICTGLPFDLFQSQRLDAANPLSFVNDLDNSFNFPLLQSTELPGFTNLAIFQLDFHEELSLDLPVAHSNLEQDEFVSRSTDPTNSRVIAKECQINEKSQFDVYPDYLQHESKAKPSDERDMLTVDRSNVKIPESDINQAEPEHSKTYGHATSASFLEHQLGPTKWNIFTGKLVKRGKASKQQESSSGIIDLLVKTEIIKEALCRFLPPAYSEVDYAVHTWTNGRVLLTRAAVFALSGWSKVFFSYWSRRVERLALFSFHDHRLRIISSELERRLAEDLADSFNHGTSAHVEPNCHYAHSCCSTDTVVQSFTQMTTRRLDAVLKETKERTGFDTTKLRGKRSILDPYLVMKDRFFAISAPKSAHSQARFGAFENANDVRRETISSVGKPIEPSQSNYVGSILVHSFNKSRLKPNSHPGQSMFKLQHAVDLTADAAKDQSEFEFEWQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK46</accession>
    <name>A0AA38NK46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_335901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793507">
        <property type="protein sequence ID" value="KAJ3781999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK46"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="222" mass="24882" checksum="869173D892706197" modified="2024-01-24" version="1">MEEDDEVSRVVPPWVELEYAHMRKLAGLGSQVHFTHLSKSSSDSLNAKFIEKASDGQANAICHESGVLDLIKERLGGSLEKVCLLDPKAEKELSPEDGDGRFEWFLFGGILGDDPPRDRTAELRVLGFPSRHLGPTQMTTDTALGVTKRVVQDKVPLDKIPYIDHPTIKFNAKESVEMPFRLLKFGIVSNRQSEYIAENGEPLLPPGMRELLFEDMNKGFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL68</accession>
    <name>A0AA38NL68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_295527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793406">
        <property type="protein sequence ID" value="KAJ3783724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="181"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="274" mass="30060" checksum="8D069027FC6DFBC5" modified="2024-01-24" version="1">MSFQDIEAGFGPGASNNTTSLATPESPEDAAFRSLQSSLSLQMLKMNANVQGILKLVDQLGTGRDSAALRKSLHDLTDTTRAMAKRGSEDLKKLTTQQAKLPHQKTSLQKTSHDFQLSLVGFQRAQQLSAERQRTVVQGVKMAVDDNGEGAETHEPPSSPSQRQAQLLQAQLSPHELAYQESLIQEREEDIREIEAGVHELAEIFRDLGTLVHQQGGMLDNIDYNIQSVHVDTSRAAEELTTAHEYQRKAGRRAACLMVILIVVVAIVLLAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLG7</accession>
    <name>A0AA38NLG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fruit-body specific protein a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793386">
        <property type="protein sequence ID" value="KAJ3784204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041378614" description="Fruit-body specific protein a" evidence="1">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23622" checksum="80FB93F5F3F591B0" modified="2024-01-24" version="1">MLSISLLFIALASTTAAIYLPPFNTIDSTESIVLSLSASNHHGAPNPPDHTGSIPGWYYGDDPVSADGLPWLKDTDLCAVLASTRHTLRCPVIQKQPTKTYGKRSAEIAAPTQHSNFAVYDPTPSYYTVFSGLTGAINGPGYLTYGLVDTEDDCEAMCNSVSGCVFVNAYHDVNGKNGSPLLTCSLYSEVNGAEQATNYGGQLQPDGSYDYITDSDGYALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLS6</accession>
    <name>A0AA38NLS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_19823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLS6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041251353" evidence="1">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="177" mass="20010" checksum="E5C5397CDCDF6B71" modified="2024-01-24" version="1">MLFTVTTSRLFTLLYLCVSMLTASGSPLPTDGATGFQPELFRRESELEVRLGRHKSIPGKKPIRHVLLAIGDVMVSWSDTSKTQLLPEQIPEEHLEYCRDNYDWFPLGKAKFNSPAAKELALKALLSIDLPLHKEPGGNCWDYIESALKTLKAHDALPDSVSTLKEFKENEEKFRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM00</accession>
    <name>A0AA38NM00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate esterase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_6454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041400051" description="Carbohydrate esterase family 16 protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36219" checksum="FFCF30DEDD9BA083" modified="2024-01-24" version="1">MPILRLSTGLLIGFVLNAAIQPTRTRAQSQMNFPVTVNITSPITLAVQPLCGTLSSENFTEINTGIQLGPTRTIVAFGDSWTSNGANGTVPVPPILWPPSPSAGSQFTENRRASNGFIWVEDMANELSAKLLNYAWGGAVIDNFAYNTTTPLNATGVQRTDFVAETVLFLQQGKFLDALVPDETIYTVSFGINDDGQYKIAGGNMTLAYETYVTKLGELQANGATNIVVHGMYKHTPEIDLLQNQIFAYLRESNVINGTNVAFVNLERLFDTIASDPSAFGYRGNATCLISANTIVGGCDDPDHSVFWIPGHPSQNSHRLISEYTMAVLEQCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM26</accession>
    <name>A0AA38NM26_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_269156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041470892" evidence="3">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="4">
        <location>
            <begin position="85"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="322" mass="35259" checksum="A0B24571C3406099" modified="2024-01-24" version="1">MKLLKFLSVTYAVLSASLAPQVYCDSHRHSRRLIGVSNDPTIFGNTLNFWRKLENGWDLTRGATTHSISLSTPQNGPIVIQPNASALVIIDMQNFFLHESLNGDPKGRAIVPTTITLIHAFRNAGMPVLWTNWGMTDYDIINAPPAFIQGFSSDDTSLTSFGSEMGMVVVPESDQSIAATSTTPGPNITIDAGRKLTRGAWNAQPWGDLFKEQIEGVANGTDFYFNKNRLSGMWGASTPMQTWLQDNSMTTLFFGGVNIDQCVFGTLVDAYYKAYDVILVDDVSATTSPSFATQMVDYNVGLDGWRVNSTDILPALMNASMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM68</accession>
    <name>A0AA38NM68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_312414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041250714" evidence="1">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="197" mass="21286" checksum="441657EB7FA7A77D" modified="2024-01-24" version="1">MPFNPKSFIATCLLMSVHTLATTVWRTHETLGNNFTLAALNKTLSNANFTGAPLVLGSAGAIDGESFYVSSTYYSYPYDEYPSLGLVNGNLRAFDGGGNWHTNASVPFLGYEALSWATSTLYSDPAPTAFSAATIPASVYPVLAVNGVYDMWYLCPSDRRLGQDSVYYNTTFIGSSKGSLSTRISCYSVTLNMVPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMA0</accession>
    <name>A0AA38NMA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_387078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="619"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="563"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="923"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="957"/>
            <end position="992"/>
        </location>
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        <location>
            <begin position="1039"/>
            <end position="1077"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1695"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1747"/>
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            <begin position="2303"/>
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        </location>
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        </location>
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        <location>
            <begin position="2082"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2331" mass="250161" checksum="264B09B9A6285D8D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMK7</accession>
    <name>A0AA38NMK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_309586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMK7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000039">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF874">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="223"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="378" mass="42516" checksum="40BBAA64DF3BBF33" modified="2024-01-24" version="1">MVITFMDLPIIDLDLFLSQPQDSPAVQDECKKAADALITFGALILRDSRVAESDNSIFLDLLEDYFAQPPSDIKKDERPELSYQVGVTLENTEKPKCAADEPCLRIIERLELSERPLDISAHSPDPKCRFFWKMGEKPTYETQFPGLNAPNVVPQAEHIKARWTPIMKSWGESMKQAVESLADMACIGLGLPSNLFRDAGRYGPHLLAPTASDLVKYGQKDTILAGFHTDLNFLTIHGRSRYPGLNIWARNTGKRLPVKIPPGNHLLVQAGRQLEHLSGGLIKAGYHEVVVNDQTLQVIERRNVENPDRPLIRISSTFFWHLSSDYDLIPIPSLVERAEALDVAQIQLRGYVTDKPVYQPMKVGQQVQYELKHIALMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMS4</accession>
    <name>A0AA38NMS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_153373</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3787114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="178" mass="20112" checksum="910CFB31F81A0A08" modified="2024-01-24" version="1">MIKIWSMKKNEELAGKKKPKTSAAQIRVQKDLTELDLPSTMKTHFPDPADLLNFSLTITPDEGMYTGGAFNFSFAINTNYPHDPPKVKCTQTIYHPNVDLEGNVCLNILREDWKPVLNLNAVMVGLQYLFLEPNTDDPLNKEAAQEMSKNRDQFLSHVKSSMRGANIKGVQYTNVLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN64</accession>
    <name>A0AA38NN64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_155967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793817">
        <property type="protein sequence ID" value="KAJ3780275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN64"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045:SF34">
        <property type="entry name" value="ISOFLAVONE 7-O-GLUCOSYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 72B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24003" checksum="D80C2D8958E53836" modified="2024-01-24" version="1">MQREFGDQSLLYMSFGTVFWPEEDDRVWAVIDGLLEKRQPFLFSHPSPFLRFPDEVKKKIDASGIAMELSWSPQEMILTHPVTGWFLTHGGWNSVQEAFTHRVPMIFWPFHADQPYNAMRLLALKAGFELIEVRTGPIGARIPYKCKELPAFTPASAKAEIMGLIEKLKAQEGLIVRQNFEAVADAVCKAWDTPNGESRKETKTMLKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNP2</accession>
    <name>A0AA38NNP2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TspO/MBR-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_344371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNP2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="20290" checksum="1BD2886D4FD27491" modified="2024-01-24" version="1">MFSLYLPNVLLAIARNPVTALGLPLAFGVLSGLPTAKVVRGPWYNNLFFPPGRPPRQVFPFVWPLLYLSMGYASHLAVKALEVSVSSSSRASLTLGIALYYAQLGMNFAWSPLFFGFKQVGIALIDSILMAGTTLYAAKLLDRPTGSQTTYFLIPYCGWLCFAVYLNAGIWWLNRGRRLEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP12</accession>
    <name>A0AA38NP12_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_436605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793473">
        <property type="protein sequence ID" value="KAJ3782480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="13562" checksum="A296703F83445844" modified="2024-01-24" version="1">MSYSYPYKKIDLYEVARIDPELPIETIMINLITLRDDVMDIHSLSEYKKDLIAANTQLGVAGLAHSPLGPKLLTGTITKSFADDLSEGDYRARSNRFPEDTEANLAIVGELRAIAANNNPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP70</accession>
    <name>A0AA38NP70_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_56393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793424">
        <property type="protein sequence ID" value="KAJ3783350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP70"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="628" mass="68773" checksum="CB743471DDEC6B36" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPA2</accession>
    <name>A0AA38NPA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_377304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPA2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="295" mass="33514" checksum="72EAE07C750843CA" modified="2024-01-24" version="1">MSSGNLRSRRAMEFPPELERQIFFFAMRSDPSIVSSLRLVAHRVRIWIDEILHEYVLLDNWGRSEGDLKHGLGPVPGKGQLYASHISPAFAKNVSSLCLTYNHELTTDQLRFLPSCTALSRLALWVDFTECPELTAVLVSLSLQTLSLEVEHFMRLPSFPSVTHVWTSRLTHLELVFWTADINLDTLCFAHIPALQHICFVWGRRTYPLTVKIALESCACLRTLVILTASGQWAEFDYHRNLPEAKGTNIVLLPSVRQATYEWVPGGPTVWDRVQKYMASQRSTTASNAQADRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQY0</accession>
    <name>A0AA38NQY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_343424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQY0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="159" mass="17493" checksum="9E23C0BDFEBB001F" modified="2024-01-24" version="1">MPKVVSRSAVSSSTDAQPTASSAAALRVYYCICGEFILVIDTNLSALPRRQSDQSTIIRCRESDTAAARVFKLNATSGDPILIERNGGHERQYRFLCPRCTLPIGYQSTPPPVKSGPFLYILPGALTQMQGQLPQGALDDERDAHLDSMCIFVEYHQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR01</accession>
    <name>A0AA38NR01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rtf2 RING-finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_49832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR01"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="295" mass="32500" checksum="DA62D8F0BFACDF75" modified="2024-01-24" version="1">MGNDGGSIPDRRDLVRTKAKAEQADKANQTRARWFFCALSKRPLQDPVVSCALGKLYNKDSILEYLIDKSAYGDGENICGHIRSLKDVKTLKLTPNPSLSSSALSEPTSRSPFVCPLNLKEMNGVQPFVYISTCGCVFSQAGLKTVVSASSMSSSPKEKDSHTELGEVATSDSELEICPQCATKFSRKNDVLMLNPQPEEEERMREKMELQRSKETKKTKKRKNASPVDDTEAPTKKKALPAMHPSMTAASRAALAMEEAKRKATMSEAVKSLYGDGKPAKKETFMTRGTFTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRG0</accession>
    <name>A0AA38NRG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_25282</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRG0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041230051" evidence="14">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3789771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="520" mass="58463" checksum="4DA185AF077407E8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSF3</accession>
    <name>A0AA38NSF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_282573</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="399"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="626"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="754"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="809" mass="88237" checksum="AAD4568D2B15ACEE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NST6</accession>
    <name>A0AA38NST6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_329114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NST6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="168" mass="18895" checksum="565B8D9DC938418A" modified="2024-01-24" version="1">MHVAGIGLGEIRSPVSTTWASQDADSGPAKWDLRAIYRKISDLPTNWEVEENFDSPPKSKAVKDALKRNDRKGKRAATHERELYRPIANLLNALRNGTGLVDDGLNEKMFYVQDPRLVLGSLLERKPDLDGIYAQLRELAENKNLSTYLSKKKIVGVFLGLLIFFVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSV0</accession>
    <name>A0AA38NSV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_302920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000008">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="188" mass="20329" checksum="339A0F6F8405991C" modified="2024-01-24" version="1">MFRSAISRTVARSAVISRPNVSRVTLRPALSRGYHEKVISHYEKPRNVGSLPKNDVDVGTGLVGAPACGDVMKLQIRVDENGIISDVKFKTFGCGSAIASSSYMTERVKGLSLEEAGKIKNTEIAKELCLPPVKLHCSMLAEDAIRSAIRDYKSKRNNMTNPKQKGFIDVSQSVVTGETVATAHPGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSX8</accession>
    <name>A0AA38NSX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_417823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSX8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="411" mass="45420" checksum="9F2A38278F0FC35D" modified="2024-01-24" version="1">MANPSVSTVNQQMWDEALKSVLSLSKATIKHNMELEARVSELEMELSVWKRAHSVALEASERDNLHVASLQQASTPDDFERQSGDPLVLCVINGQQTFFNQTLLTQGFMGGQSAAQYLTRAISEYLTSEDIQITGRLSFLSFWVSIYFNKSELVNMLVGQSICSREQLEGFLAGFSETSPRFTAVDVGIGEGAADRKIREYIRTYTRLPETLRTFMGGCHESNALYSGAFDCLQSENLLEKLVILRGLSEDWSDHTFPIHVLNVDKLLVQQAPHPSMQQLAPLGVPFLEPAPGPANGGLVSPQSPVRNGLRYPDPRYVSSKNPPPCNEHYLMACSKGAGACKYSHDYILSPEQLAVLAANAKKAPCNWLKSGLQCPYGELCCWGHVCPGGSHCFHLRKGKCWFKGEGMHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT08</accession>
    <name>A0AA38NT08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_302930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT08"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF19">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="372" mass="41767" checksum="DD7E830E511A1AEB" modified="2024-01-24" version="1">MSSITFPHGTLASQSSHQDISDSQYYPQFDGSSGFQMNPLSSHPPRTPRVSVVSSHTFNSSVYEKDELSSNLEAESIDEEEDVRMNEAERRIRHEEVWREIVLTSNGRDKAFKIIQYSIKVYLLFHTSVTGSRLLRKSIKQNWEQELVKRLTSTVSGLSFSRKCLLLFNWLSPLTAILAQQAVPFSSDSATSKKSDIPRPFLHAVLNAPPPVLLELVNAISDDLYTLSLLGILGKRSGDRAARLSDWCWFLATLVGLVENGVERQMNGNLQHEAQSRLYKESFSGATAKSKPSSTKIDDKELARLQKQDYWLQLTRAKLVMDLIFVSYDIFRLKKARNSVKALTGLIAAILSSAKLFDRHTTALTKALGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTF6</accession>
    <name>A0AA38NTF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide lyase family 14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_339417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041450111" evidence="1">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="2">
        <location>
            <begin position="87"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="343" mass="36922" checksum="7320CA8900A0B165" modified="2024-01-24" version="1">MNFCIYSGFVAILLLSSSARATQASPAALASQYSLSTSTSLPYPTATLSSSNSQSLIISQWSLSKGRIQDQASDLAFVANPFSEDSSNSSSPVLQVTYPAGSYSHNTGGSQFENLWNTTDGSSFQSMLLSYEVAFDKNFDWVLGGKLPGLRGGTNATGCSGGDEPTGLDCFSTRLMWRPDGAGEVYAYIPTTSTFCQETDIICNSDFGVSISRGSFTFVSGEWNRITLFVQLNDPTTTANGNLQLYFNDQQVISRQDLQFRRGSSVDINGFYFSTFFGGSDDTWATPATTHTYYRNIQLWGGANPANGTTVNSAVNPALRTIRPINSLLILVSILATACGILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTT2</accession>
    <name>A0AA38NTT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_338476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="800" mass="87487" checksum="B0483F8A67F3682A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTV0</accession>
    <name>A0AA38NTV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_64494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="457" mass="49928" checksum="BDDB047DF58EB7A0" modified="2024-01-24" version="1">MSYLDPYDVTAGTATPPVQTEQSLNDEVSQVIGQLGRFWGGFKKQSQTAFEVARKDLTEVVTQAQKELHKFTGDASDEAQTSSTPHSDEPQPRSSSETLKPDATPSAENEGTSTSTTSIQTLFTRLQSSLPPNVVSTVQANLPDSLKHISESTDFAQLRTTLTSEFQRLQGVTRAQAEEYVHKSEVLLRDAMKEAGEVLRDAVKVLPPDEAASSSNNTGLIWDGSDMWMLPSESGDLPVSGKGKANSHNAVATRAEALLRRLKSDPSILKHNPEVDGGVKTVYLEWIAANVEPMDGGIESTHWTAKIDETLKSEDGKTLQSTFDSLVPSELSKNEFWKRYFFRVHQIQAEEDKRKVLLQGTMENEDDFSWEDDEADDGSASTLPKDNETPKAQPDSDPAANKSSAPSSHLNTPANTSPRVSSEESYDVVSGNVSASGEKEDEKKAVEESSDGDSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTX5</accession>
    <name>A0AA38NTX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_338526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="62" mass="7008" checksum="EC0B845054C16699" modified="2024-01-24" version="1">MAGHASGGFNPHLPGFRYNFLAKGLGATMWFFIFYRFRQDGGKLLGHHPFEGHGDGHDEHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTY6</accession>
    <name>A0AA38NTY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_65212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="213"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="541"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="853" mass="96336" checksum="24D785D56798B4CD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU19</accession>
    <name>A0AA38NU19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_301969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="89"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3791133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="758" mass="83912" checksum="BBAB66F3F1837812" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZW4</accession>
    <name>A0AA38TZW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="8" type="ORF">GGU10DRAFT_340896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="250" mass="28344" checksum="5FF2EEB860D3BF32" modified="2024-01-24" version="1">MLSSRLVKPLLQISYILLVLGTFCATLLSCVAILSQAVRTAPNRSWNKNFNALIIGASYIILLIASIFFCLKRTIAVRIKLSRFSRTHKTITRGDVPDSVHKYITEEYARTCLIAHQSQPTDAFHEGWGKPGGQYEGVRFRRALLNTIPKIDSLAHLVIPTHPPLKPHARMIHHFRFILPLLPSNEDELTPLHYYDSIVQLARISHREPTEEEFELGMDSADVIMQALNECRLEMLEGSSTQLNQISEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0P9</accession>
    <name>A0AA38U0P9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_303938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0P9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="158" mass="17734" checksum="CE9C4DB9604774A0" modified="2024-01-24" version="1">MSTIPFFPYTVFFLYIEPLSALAGAYYAAFKPQDYLGDLSLSNAIANPIIPLVTTQMNMALLQLANLYLLFALNEHLVLSSTTSIKTWKRMLFCLLIADFGHLLSMAPLGTDVFWKVWEWNAMVWGSVGFVYLGASMRISFLCGLGLSSPNTRRTKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0V5</accession>
    <name>A0AA38U0V5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">40S ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_2607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0V5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="22316" checksum="2926136F54B25226" modified="2024-01-24" version="1">MPRAPRNHSKTYKVPRRPFESARLDAELKLAGEYGLRNKREIWRIGLILSKIRRAARELLKLDPKDPKRLFEGNALIRRLVRIGVLDETRMRLDYVLALKVEDFLERRLQTQVFKSGLAKSIHHARVLIRQRHIRVGKQIVNVPSFVVRLDSQKHIDFALTSPYGGGRPGRVKRKRAAAAAKKEEGGDEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U349</accession>
    <name>A0AA38U349_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone acetyltransferases subunit 3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_301636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U349"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="651"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3791263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="708" mass="77572" checksum="9DD55A49C839009F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K871</accession>
    <name>A0AA38K871_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793565">
        <property type="protein sequence ID" value="KAJ3781389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K871"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="377" mass="41879" checksum="1D04D1E5468F14D5" modified="2024-01-24" version="1">MTSSDFDLGLDDLLPSSTPSRGPRAGDKRRSSQRDEDDEDFGPNTPAYPGTVNRNVVSAARRIATAKRFRPEQMTELDAFLNDSAFGREARSFIQNSEILSKLEKIIVNQPAWEVTKQLKENIKHYVAAAILSTSLISFRSTKTAKLISQKLLDLNLDLPENFRHNAATVDKLEEAISEELTQRRGSIKKEIRSSMSKNGGSNRWQRLPDNECSNIYELTRALVKNTRCSVTPELCARAAILRHAYQKNNGNDFWKQVDATIQELRRKGEGDKKMTARWVKAMLDQDCKKFSNGINVDPGAQESQSELQTEMDQLIETSQLASGGQDNSADDVLGSADQNRQGDEQSHADRSRGASKASSARSSPQPEDGDNGDGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9H4</accession>
    <name>A0AA38K9H4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_358547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793385">
        <property type="protein sequence ID" value="KAJ3784239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9H4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="65" mass="7349" checksum="E141899BF6D67DB7" modified="2024-01-24" version="1">MLPSRTIVLYSLLALLNMGVRRSFLSWALPMCYNPCGIDLCPIVVHIDLTLTMVFLLRTPKLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAJ5</accession>
    <name>A0AA38KAJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_352056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAJ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="151" mass="16039" checksum="2FC02F5F1BC30F56" modified="2024-01-24" version="1">MAPKKGRVVREENTVSLGPQVAEGELVFGVAHIFASFNDTFVHVTDLSGKETISRVTGGMKVKADRDESSPYAAMLAAQDVATRCREVGITALHVKLRATGGTGTKTPGPGAQSALRALARAGMRIGRIEDVTPVPTDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAU2</accession>
    <name>A0AA38KAU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_310290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000836">
        <property type="entry name" value="ABC transporter B family member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1259"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="67"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="453"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1324"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="822"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="850"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3786774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1567" mass="170104" checksum="07FAC82892AF3742" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBH3</accession>
    <name>A0AA38KBH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid droplet-associated perilipin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="379" mass="40820" checksum="BD2586297DF0416A" modified="2024-01-24" version="1">MSSTQTETSTIPMPSPPSQNPPELTVISRISSIPLISSSLEIVNGTLSTNAYTRSPYTRALGLSNSAYKLTEPLQAQLAPLIVRADSYANLAVDAVQKRYPNAFTATPEDVMGYVQNRQKDVGEYVRERRESAGAIAQNIDKKFTPIVDYLEVAVNRIDSNAKENSASVDKDVQSQISQYSRALELSTRLRDQLQFYSNEQMKQLQAHSVLVQSATETARSLSATASSSLSNAQAKLHTVSENMIAELGKLQAQAASLSASLQATASKTLKDPTAQFPPQIQQRYIEVTSVLHAQASAASATYADLSNNLASTVSELRSIMAAENVSMNEKATRVTHEVSVKVQPLLEVLSRTVQQALGGLSASQTSMPTTNGANGHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBR2</accession>
    <name>A0AA38KBR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_397774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793714">
        <property type="protein sequence ID" value="KAJ3780523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBR2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="511" mass="59319" checksum="C7D786F390DBA20A" modified="2024-01-24" version="1">MASAAGKGQWLSRMIRQWTVSFCEDHTWVPLAQYGKFNSSILEDEDIADDIRLHLQSLGKWIRAEDIVHYVDTPEFRARLKVKKNISVRTAERWLKRMGYTWRNELKGQYANGHERQDNVCYRQDEFLPKWMLYEARTRWWKADGSEDGNTMERILVADPNGKIVLRWVHSSETAKPYAKGEGASLMVADFVLPDHALLKARQMKDEKGQLKHARVLFQPGKTRDGYQTTQNILDQATIAMDILDADYPDEQHVFAYDNATIHTARSPDALSATAMPCNPNASFFCKVMGKDGEVEKRVKMKNGTFRDGSSQELYYPADHPDYPGHFKGTRVLIQERREKGHELPDPYEPKKPGGKLFKLKGSCKKCPTDSRNCCCRRVLYFEQDFVDQKSMLEEHCERQAYQIIFFPKYHCELSFIEQCWGYAKNVYRMFPTSSSEADLEENTLKALDSVPLVSMRRFATRSSRFAHSYFSRLNGAEAAWANKKYRGHRTIPPDFRAEMEAHFKKNRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC30</accession>
    <name>A0AA38KC30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_230199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793614">
        <property type="protein sequence ID" value="KAJ3781018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC30"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="12984" checksum="63D0FA7D88EE866E" modified="2024-01-24" version="1" fragment="single">LGPISKHTTFDAEGVGILLGLSIIDKYVFDPNPRDTLICLDGRSAIEALRAQNTTSGKNIVDATLQLARQQARGNGSEQIATVTWIPGHCGIPGNEKADEEAKKAAAGDVSLARDLPDYLAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD66</accession>
    <name>A0AA38KD66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_378035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793440">
        <property type="protein sequence ID" value="KAJ3783028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD66"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="455" mass="50365" checksum="A8E27E095C693080" modified="2024-01-24" version="1">MSFVNSPQHLHEDLQHLRQYNGSNLHFVNYNQTSRTEYGRNYDQRNPLHAHNQHAVNQAHELCSTELYYHGTSLSLLNHPEANNHPWLSHPQNNQLDYMSSTASPVYHFPTHLNPSRHAAVTGAQAASQTIFQNAGPTHSDLYPGTQHTLAGSLDPTTGVFYRTPEHPRLRTAQACEKCRTRKAKCSGEHPSCKRCLNRGLVCEYAKEGRVRGPNKPKPKLSVQPEMSSPLVGQNQFSSSLEFKNTIPSTVAACPPRRYVSPSILPPSMSASLPSPSSPCSTGYDGLQSPISPTGTSTPDSTVGSHCFPDPNSSCGGRPEQRFPSTLRHSCNGYGSNSPMSNLPATSFRTMAQTLPQRPYSRPSSVFQSSNVEQPTAEMISSSRFFTLDHAEKSAREIANFRSVSLAEYSQKVPGFEDVAYYPREGASAQRSRSYDLPNFFPDEGSELRYNPDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG90</accession>
    <name>A0AA38KG90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG90"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="602" mass="63343" checksum="9E0C6F25B0FE0C2B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGS9</accession>
    <name>A0AA38KGS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_374956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGS9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="603" mass="66144" checksum="2CBD37CE2BBEB382" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHH9</accession>
    <name>A0AA38KHH9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_348208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHH9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="514" mass="55198" checksum="EAE56846386B6EDA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKD6</accession>
    <name>A0AA38KKD6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_168104</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="MU793914">
        <property type="protein sequence ID" value="KAJ3780104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKD6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="617"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3780104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="682" mass="76060" checksum="EEAAE1D5A90C574C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN21</accession>
    <name>A0AA38KN21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycopeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_428892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN21"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041219420" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="156" mass="15841" checksum="931C6C682C1BBCF7" modified="2024-01-24" version="1">MFSFIKLVVLVAAATLATAETHTVTFTNLCGKGVPTLKANGVTLSTGKPYTSNGPLEAAIAYLDVGCGANGEGCTTVETTLVNPTSPGSGSSTDITLIPPHAFSVTTGFGYYNGCDGAGADCNNPSCPTAFFIPTDTGVQVACQTDNVDLVITFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN76</accession>
    <name>A0AA38KN76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_61036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793436">
        <property type="protein sequence ID" value="KAJ3783105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN76"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="536" mass="60967" checksum="1F2D7A34BE10A285" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR28</accession>
    <name>A0AA38KR28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kinesin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_176674</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR28"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="63"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1067"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="443"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="769"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1083"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3786270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1165" mass="129378" checksum="9F7683A8DBE3F4F2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR45</accession>
    <name>A0AA38KR45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_290477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR45"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="136"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="324" mass="37828" checksum="8015CA5239816C63" modified="2024-01-24" version="1">MASNATASVFDALYPSTDLSSLNWAEQKWVAWYVWWGNPIIATGMISFLMHEIVYFGRSIPWMIIDAIPYFRRWKLQPNKIPSPEEQWECIKQVLWAHMTVELPTIWLFHPMAEAVGMKTYQVPFPSYSTMAWQIAFFMFFEDLFHWTAHRGLHEPHLYKHIHKLHHKYSAPFGLAAEYAHPAEVFILGMGTLAGSLILCLFTEVHFVSFFLWVIIKLFQAIDSHSGYDFPWSLKHFLPFWAGADHHDFHHMAFTDNYATSFRWWDSIFGTDHQYHAYRARVNAAKAKARTSEEFFKAEQEINAQVLSEGLLTEAALEATLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRF5</accession>
    <name>A0AA38KRF5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_294259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041342469" evidence="3">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="60"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="357" mass="39728" checksum="D02093731BC54F5F" modified="2024-01-24" version="1">MLYQALTAVFCILSAFSTLAAAQTASNASLLDPSLYKNVNVSRGLVYHYYYSPPSQVGRPTLLLLHGFPSTSYDWRHQVAFFQDEGYGLVVPDMLGYGGTAKPVDPHLYKSSLISRDMVDLLDAENVNEAIVIGHDWGSKIVGRLANYFPERFSAFAFFSLGYFPPAVLERSFAELNNITEQVFGYGIFGYWGFFSTEGADNIIESHLDSFFDVTFPADNIFWITDFAPLGALQAWLEANRSTAAGSYITPEERALQIDAMRDEGMTAALCWYEIMTSTIERDDDQGIPQENLTIKKPVFLGAALEDYVAVAATQIAAILQVSENTTTIQQYDSGHWVILEAKDQVNSDLLSWIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRP8</accession>
    <name>A0AA38KRP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_376435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793364">
        <property type="protein sequence ID" value="KAJ3784791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRP8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041232680" evidence="10">
        <location>
            <begin position="25"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="502" mass="56678" checksum="98E3D2F7FD1A7DE8" modified="2024-01-24" version="1">MASSSTWLALGIALVALYAARCVADDRLTKLKYKDVVFVGPTGTFGTVIGFFQLLLGFRDFIQEGFEQHYGKLFAIPTLFQMTFVVSGHDLIEDVRKASDDQLSLYGSIKEGMQTDYTMEPHILENPYHFKFVHLALTSNLGGRYPELREEVITAFSELVPPTDSWTSFPAWLTGKHVVLRVINRLFVGPSLCKNAAYNEINDIYSDALVKTALIMGFTPGPLKPIVSKLLDSYIPKTLRRAMEHIGPLIEERLDQERMFGKDWPGKSNDLLTWLMEKAPESEKSLKAITIRLLATVFAAYRPASMALTQALFDLATFSSYIQELRDEIEPIVKEEGITKESINKMYKLDSFIKESLRLRAGGKSSMPRKVLKDFTFSDGTTVLAGNTIIAPGYAIHHDARHYPNPNEFDGLRFARLREEQDDPVRYQIISVGPTFMMFGNGRHACPGRFLVSALLKTMIVHVLMTYDIKLEQDGVRPVDKWYTFTPAPNQTAGLMFRKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRZ4</accession>
    <name>A0AA38KRZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sec24-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_147645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="7">
        <location>
            <begin position="221"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="9">
        <location>
            <begin position="474"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="719"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="864" mass="95168" checksum="A8D70965FC574E81" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSF6</accession>
    <name>A0AA38KSF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxyneurosporene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_287379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041201371" description="Hydroxyneurosporene synthase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="3">
        <location>
            <begin position="231"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37088" checksum="A9BFA22E9E8B4457" modified="2024-01-24" version="1">MFFQSLLSLALVPTLIHAATVTFPPTVGLGTSDVQYISSSSTFDSLKISNVNSTTYEWYYFDAISDDGSYSVVATFFVAPNTAFPFTGSPTMTLEVLLSIQTPDSDVFYLNGAFATDAQVSTDGDGASGVWEGTGLSFNGSSDMSSYQVVIDSAASMGVTGTISMQSIAPAHYPCSANEAGATMQLMPNVGWANAIPDSQATVQLEINGQNISFTGSGYHDMNWGDIPFENAVSTWHWGHGRLGPYSLVWFDGTSRDGTPYTSGYVSMNGAIVDTQCSGVNVTATSSGFDIEIDLADESVFQAQFSTDHTLLSFDGVYFRWSGGLVGGISGGEQYTGSAMFDEFDFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT29</accession>
    <name>A0AA38KT29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_394582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="263" mass="28704" checksum="A40E005062B6217E" modified="2024-01-24" version="1">MKPSNVSPRPILKRSPSTCHENDSELPFYGIQAVHFPPSPSLSRFYHAHPSSIYDRSPIVVSANACALPERGCPGRTYTLDERNLSASQQPTIPAPPSRGGHLHPRALSQWPVQYLPNGSPQCPSLIPDLSSESEESDGFISPPPETSFASFGPNSYSRRADKHPSQLSLDNAVYFTAKLDNIQHPSPVDSREKSRPDRDRIRSPAGPGEVAADDPGYDDDRDVPPSSPRSISPRKNRSRKHLSSRAKVGFDDKSDGGCLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTQ5</accession>
    <name>A0AA38KTQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_309053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTQ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="578" mass="62371" checksum="06B98C45C4AEB12C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU73</accession>
    <name>A0AA38KU73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase I subunit RPA12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_307754</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU73"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041315051" description="DNA-directed RNA polymerase I subunit RPA12" evidence="13">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3788136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="13586" checksum="7B7F2C01C271C3D8" modified="2024-01-24" version="1" fragment="single">MATKIGSLLFCPACGALLDLPKDSEPNVLCEQCGYQEPAKSYENIKITTRSHPDAFPSALRQKRKTQTKTHDSDNLGDLVSEKCPECSHSEAYSKSLQLRSADEGSTVFYTCASCKHGWRVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUL4</accession>
    <name>A0AA38KUL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_345071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="6">
        <location>
            <begin position="155"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="407" mass="47070" checksum="BCC171D086F465E1" modified="2024-01-24" version="1">MVLSVGQPIDRYASSCGYCSPPGERSKTDSSRTAAALNALQLSPEVYQKMINRGWRRSGRFCYKPHLRSSCCPLYTIKLDVLSFKPSKHHKKIVNRWNKFIQHGDDASTGKQKGKDNARFDLRSSVYASEFRDGQDQVFAHRFEMALEPSSYTDEKYELFKKYQTGIHHDNSTPQGFRNFLVVTPLHQEHIPYLSPQSNHLPTHYGSYHWCYRLDGKLIAISVIDILPECISSVYFMYDKDYEAYSLGKLSALKENVLAHELHTAGAPFLKYLYLGYYVHSCQKMRYKGEYHPSYLCDPESFEWYPLAICAELLSQHRYACFSRPERSLRGDPGPELVQDFEWSDPQEPEERALEHISVISEVDGSQISVITANLFLDREYPFYRRAFFFCIEELGVDLASSIIFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVT8</accession>
    <name>A0AA38KVT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat-containing protein 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_356862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793364">
        <property type="protein sequence ID" value="KAJ3784767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="332" mass="35140" checksum="6298127EAB148CB9" modified="2024-01-24" version="1">MNLAFLNAHDSSETHSDAVWGISWTKNDTVVSISADGSIKQWASSTGEPFSPSVSTTDYQVPSPHTLGLVSLSVSPDGRRALYNSLEGLSFLWNLETGVTEGTFESYVKEEGTGNTESSWSVSLNPFGSTYASAGGHGNLTIRSAESETFGQKIATVHSGRNKFGMCCSYSPDGKRIALSSEIGHVFILDVESKTFVNTFTSHAMSVRSVAWSPDSNLLLSASEDRRLILYDVRVSSGNSGGAVATFSGHSSWVLCADISPDGRFGLSGSADKSIKVWDIAARAAVSTVQDTGEVWSVSWRPRAPAVGSVGAFVSGGEDGVVKWWTSAGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVY3</accession>
    <name>A0AA38KVY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_356230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793357">
        <property type="protein sequence ID" value="KAJ3784977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="773" mass="87269" checksum="F88E0EBF1C7DB214" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW27</accession>
    <name>A0AA38KW27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794376">
        <property type="protein sequence ID" value="KAJ3779693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW27"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18659" checksum="D03AE08667FFF44B" modified="2024-01-24" version="1" fragment="single">LKRIHSCIREVVVPSWLAKPPFETGLKRAGTLKADNWRTLFSLYVPLALLSLWKETSPIRSDDYAEMQPVLDTSMHLCCASILMAKRTVPLERRELFLHHYTQHIKGLRQNFPGFGVPTHHVAFHVYDFIKLFGPVRNFWSFPGERLIGKLQKTPTNHIPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW94</accession>
    <name>A0AA38KW94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793945">
        <property type="protein sequence ID" value="KAJ3780068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="215" mass="23512" checksum="504D8D3AC45B5ED6" modified="2024-01-24" version="1">MKLNTAKGSCKVIVEAIVEVTVEAIVETIIEATVKVIVKTIIEATVEPIVGAAGWTLHGRNTLSCDSGTAETPAIGSRRSTVIRGDHSLADGRNGSRSEGDGNWGNWTSTLLLVSRHEEEQRNGYKSSWENSRVQTNHLLVKAVQPERIMIEVPKAPDKVLSVGIVAVTQVCTRKGYTLLGSEMGLQQCSLHTIWVSLRSAKKKEVLERWTEPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWD4</accession>
    <name>A0AA38KWD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_353791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="391" mass="43938" checksum="168177B51E81E4D7" modified="2024-01-24" version="1">MSSNNPTIQNSPDELLRAIFATLTPGELTDCALVCKVWSLPARGRLYEHIDVRKAPNKMTHAIRSAMLCQTLDAAPALRSIVRSLCVISYFPSTILPEVQAVFLHYAAIPSITSFTNIIPHLRKIEQLSFHTNISLSPSEHLHILQALGSLPLLRHLRYFAAFSGSVRKPSQLLQILNGLPPQRGSRPQLLTLDVRNITELGGFRASLEDLEWAFHPRSPLDFTQLRALSVSTYRAARYIMREVSRTLESLTFTSASRILGDTESQPPITLPVLKHLCIPSETINISLIANIHCPRLECITLIWQTVTDLDPEFMSELESPLFLIDRYITNRSNYPNLKEILVLVSSHANGLGHPDIARLHKMLPRCTGRAMSFGFGEFLERDLEYELSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWR2</accession>
    <name>A0AA38KWR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_278785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793657">
        <property type="protein sequence ID" value="KAJ3780773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWR2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="156" mass="17181" checksum="2201BB6E36F7E1B6" modified="2024-01-24" version="1">MESRFIDDQFGDLVTGTLPNYSPATGWTQGATCTGCGFHPNASQAFNQTWHDTTHHTTDETRSVQFGFTGTSLDVFCIIPNPSDPNLTSTYNLTFELDGQPLGETFTHISDSTNVFQFNVSVLSLENLSLAPHIFTMMAASTIVNSTLQFDYAMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXB3</accession>
    <name>A0AA38KXB3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_416579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="317"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="11">
        <location>
            <begin position="491"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="968" mass="108955" checksum="4553CE531F2E98D8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXQ4</accession>
    <name>A0AA38KXQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_128006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3788007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="106" mass="11476" checksum="162BAE66C0EEA953" modified="2024-01-24" version="1">MPASTRPFDVLFELVNDLNVDIVLELTPLGGGGRVSKNVLLGRGKGLSLVLDAGSTYRYTLMTTTRFSRMTIQVWNDIQCTSSSILSETGLGLPTGLTCKAMDIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYB6</accession>
    <name>A0AA38KYB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_372625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYB6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="393" mass="43098" checksum="91E7C8DC138613C4" modified="2024-01-24" version="1">MTEVTEKDLITAVEEVNPQCRINASTESPRILDNDTRDIPKVDRRPTDPFEVPDGGTKAWLCVFGAFMISITCYGVANTFGVFEEYYSANQLSNESLNNISWIGSLQLCLILLVGCVSGPLCDAGYFKHLIASGGLLFFFCLMMTSISTEYYQYLLSQGIGVGLAQGLLFTPGMAVLAHHFKRYRTLVFGIFAAGASIGGVILPIALQRLFDKVGFAWGSHSLSLHVLERALYAVRHVFLLGKEEEFWIYEFSKRLHIRYLFWVQAFVGLGLYAPVNFGVVYATDHGMSQQLAFYSLAILNAGSLFGRILPNVLATMFGPLNLLIGSCTVSSVSLYVWFTATRNAGMLAFQAIYGITSGAYVSCLPAATASLTKNPNETGSVFILLLSMEIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYV7</accession>
    <name>A0AA38KYV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_388470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793384">
        <property type="protein sequence ID" value="KAJ3784253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYV7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="213" mass="24747" checksum="1138578ADC097142" modified="2024-01-24" version="1">MSLRIAVSRLKQLSQRKAFVIHSLPALCLSTSRQVSNSYSQLHRLQNQNPHWNGFSSSRPVDSRCVSTSNSPEVHDPPTESKTTEDRVAWVLRMEHIALIANIERQTLTIDYQLARNALKLFFAHDERSRRLLKRWEQVARDFLDIRREYRELNNILANALERYNSDSDSREEIIVIKAGEDPVLVALRLYGLRESIIHIMGIIERLFLETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZP0</accession>
    <name>A0AA38KZP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_387039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3786008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZP0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="390" mass="43787" checksum="1D717897FFE73E79" modified="2024-01-24" version="1">MATKSNYGWLQGRTVRKGGHASSNSHTRSNTPQVQSTSTTIFGGGIKDPSGRTSEYFSMDDQCPVCKSDRYLNPKLRLLVSSCYHKMCESCIDRLFTLGPASCPNCDKILRKLAFSPQTFEDLGVEKEVAVRRRIAKEFNKRLEDFDDLRSYNDYLEEVEDIAFNLINNIDIPATEERIAAYKAANAALTSLNLQREEAEALALKEQEDLERREREARAAQLAQQEQQEREERQREERELIDKLETSQKDAHKIVAKSRIAAAKRSSARAASSSANSSLLGMSFGMDYAKLLKTRTTKVNNVPDEPHVPFLDDYYAYDDLYTVRAEGYDDIISEAVRRDREGIMRAGGYKVEEAWNRALLTAVAGLDAAPLSGLDEPNSLGDVDVVMESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZR3</accession>
    <name>A0AA38KZR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_177350</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZR3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3786158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="404" mass="45800" checksum="995E918D12ABFE88" modified="2024-01-24" version="1">MHLAPDTVIRNVRLLFTDPRYFWVLAALVLLGDAILSELIIQFISYTEIDWETYMIQVELYIKGERDYSKISGPTGPLVYPAGHVYIFRFLYDITDAGKNISFAQHLYAVLYVSSVALTAAIYGKAGNIPNWLLLILPLSKRLHSLYVLRLFNDCWSVVAAQAAILAIQNEMDDIGTLLFSAAVSIKMSILLYLPGLLAILVKRNGLVYTLRKVFNILGIQAMLAYPFIQKDWRAYVNSAFDFSRVFLYKWTVNWRIVPEDTFLSPGWARGLLIGHLSVLIIFGLTCWCKEDGGLWVVLGRALRRPTLPAGVVPVTPDYVATTMFTSNLIGLIFARSLHYQFYSWYAQQTPFLVWRTRYPMLLKLLLIGIIEYAWNIYPSTTISSSALLGANVITLTGVWYATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZZ5</accession>
    <name>A0AA38KZZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_350762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZZ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="353" mass="37647" checksum="60BC1295BF783534" modified="2024-01-24" version="1">MSVISTPVTEMFGIKHPILLAGMNVAAGPELAAAVTNAGGLGVIGGFGYTPKILRQQILAIKDDLVDKNAPFGVDLLLPQVGGSARKTNYDYTKGKLDELIDVIIEEKAALFVCAVGVPPKAVVEKLHQAGIPVMNMVGHPKHVQKALDVGVDLICPQAGEGGGHTGDTPASVLIPACVDAVKGKKSPLTGKPVYVVGAGAVYDGRSLAANLMWGAQAVWVGTRFVASKEAGATKYHKESVVSAGFDDVIRTIIFTGRPLHVKKSPFIEDWEHNRQAEIKELTSKGIIPTDWDVEQRPEITKNPESRPWLMGKVAALIKDILPAKTIIENMVNEAAELLEHGNTLVVKTRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L203</accession>
    <name>A0AA38L203_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793601">
        <property type="protein sequence ID" value="KAJ3781117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L203"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="218" mass="24380" checksum="426458EA14392ED4" modified="2024-01-24" version="1">MSFSISLILGPYFAGSLVAVGLSAILGFQVFLYFNIFPSDTLSYKFLVGWIWINDTVHTTLLCASMWRHLIVGFDNLETEAEIFPTDAIMVAITAVTALSANGFYGWRLYKMSKHNWWLVGPIALFSVVQIGLAFTDAAALMKMNRFSEIPGKFRNVFVANIIISATTDIIIAAARYYYIRKIKLQGFSPTQEILDGIMVFTINDGVVTWYISKIGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2M6</accession>
    <name>A0AA38L2M6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_319000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793493">
        <property type="protein sequence ID" value="KAJ3782182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2M6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="298" mass="34914" checksum="35B7FC2AF92681C8" modified="2024-01-24" version="1">MDVPDLASILIPALYTQILDIQFPWEGEVNMAFASQYYFRGTPDNSRQVFDALHHQALKPISKFRPSIPDFIRYLPDKSSPHYPEHTLALILLLDQGPRTLYRHLDVRWTYDYFDVASRKLVKALISSNAFPDAIEDWTALGYSFEDAMVRKFWLYGPLIHSEEIADHQFVERKIEKMRQDVENYTGEQDPFRKMKDRDAEDTGLFAELIRSGPPANFANFFFWLFRVFDAHRPIIAEYGRYPYRNEAQGRITTEKEGLYLELTRNFGKPTLSGEEVETLRRQKESGQWVELSDNGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3B3</accession>
    <name>A0AA38L3B3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CFS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_277661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793567">
        <property type="protein sequence ID" value="KAJ3781375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3B3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="495" mass="56300" checksum="57067F34986CF191" modified="2024-01-24" version="1">MQNITQGQLKVFTFSQIYTFPSHPETNKVVHKAELRVVNDVFWVRLCTMGDLGFAEAYMYGDVECDDLVSLFQIFLDNRSRLSNLNSSLSFLFTIPQKLTSYRFLNTISNSRSNISAHYDISNEMFAGFLSKDMTYSCAIFEDLDGDLKVSNGLNGSIDEEVGRWSGGHGLKKVGNKFTKGVPLLSLPSPPLTALANTPAIDSNRNIDAVDNLNSQNVFSEDPLEAAQYRKLHHIIRKARILPGHRVLEIGSGWGSLSMLIAKTIPNTTVDTLTLSSAQQALALERIKAEGLEERVEVHLMDYRNMPEEWKGRFDRVVSVEMIEAVGKEFLEGYWAKIQWAMKEKDSVGVVQVITIPEARFERYIREIDFIRKWVLFPGGFLPTLTYLLQTLASGSKGTLTVDSISNIGPHYARTLREWRRRFIERFEDVVVPALKREYPEVMDGKQGKKEIEVFKRKWIFFCYCEVGFTTRTLGDHIVTFTREGAQSYGCDVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3N9</accession>
    <name>A0AA38L3N9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_428755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3N9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="11">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="92"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="390" mass="41820" checksum="10D4207DC0A084C6" modified="2024-01-24" version="1">MTLNPVYEATSFKVIIRKLVDTPEVFTPDDLRVAFDKLLAPDLLPPEQIGALLTALHIHHIERRPELLVTAASVLRERALAVVVEGAEEDFVVDIVGTGGDGHNLFNVSTAAGIVAAGAGARVIKHGNKASTSSSGSADLLQALGCDFRRGACNSQTIPRMPFAFILASQYHPTLATIGPHRKALPFRTIFNVLGPLISPAQPKGMVLGVPEPELGLPFAKALRDSGVLRALIVCGQEGIDEISCAGPTWVWELQDGQISESTLCPETFGLKSCSLEVVAGGSPETNAATLEILLRSGEDIPQSKRPFLDFVLMNASALLVVSGLADTYTNGVKMAYEAVVSGQAWHALEGFRDDRKREAQLHHMVVQRPVAIPPMGCPPCLYSREHRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3X8</accession>
    <name>A0AA38L3X8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_80326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793475">
        <property type="protein sequence ID" value="KAJ3782455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3X8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="384" mass="42187" checksum="F5D61F733C74AD46" modified="2024-01-24" version="1">MAPATVASLFEPIQLGPLTLRNRVFISALTRNRSVPTNIPNAVNLEYYQQRAKSPGLIITEGVLITQQGSEWPHAPGIWSKEQVAGWRKITDAVHKEGSFIFAQLWHLGRVGHPDAPEQKAAGVPVYAPSAIAARGGKFRFIPGEPGYVTPTAIDDPTILIDLFEKAAVNAKEAGFDGVELHGANGYLVHQFLDSNSNTRTDSWGGSAAGRSKFGLLVLERLIKVFGKDRVGIKLNPTGGYNDMGMPLEETIETFSYFITEADKLGIAYIDLVRYVDLFDPVFDGKKRGTKHDVISTYAHLMKNAKVFSNGGWTGEEAAAAVTEGKVEGVFFGMGWINHPDFAARLEHGKPLDNPIDYTTLYGKYYASEEEQRKGYVDYPAAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L428</accession>
    <name>A0AA38L428_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_270879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793366">
        <property type="protein sequence ID" value="KAJ3784717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L428"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="178" mass="19325" checksum="A696E390E8BAB17F" modified="2024-01-24" version="1">MQARDSNGMIMSMDGSMDLASGNMLTYLHFTVGGDILWFQGWVPQGPGAMFGACVGLFLLALVDRWIAACRAMMEVHWAKRAQIAYANKLNANENADKKRAVSPLTPGNVFLMRRAPPFIPAHDIVRGILHAGQAALTFAFMLVVMTFQLGFIIAIVVGLGVGETLFGRYAHAGTTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4S5</accession>
    <name>A0AA38L4S5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_39678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793394">
        <property type="protein sequence ID" value="KAJ3784015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4S5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="107" mass="11750" checksum="C32F39AD622FB0F9" modified="2024-01-24" version="1">MSDISPRVNSAILPRFIGQMVRIPCKVLTTTDSTVTVQTSDGGEILVKYTGDHGISSSYAEIVGHVIDQTTVKKAAVINLQSELDLQMVDRVIKLIHDPRFFSTVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L537</accession>
    <name>A0AA38L537_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_374693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L537"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="210" mass="23547" checksum="2D1FA624E1FBEECF" modified="2024-01-24" version="1">MLQPEPFPSDNSSLLLSYPSLYGRNPSSSLRRLGSSSVLSNLRTKGARVPGNCAQPKVKNDPSAGELVGFGLTNSFNGKTAKAQGQLSDFFLVRPSNQDYQDLVLYQKPVLPTQNPIADSEGFWKCVVYGDREQIAKHKPKKSRLDEKPSKSLPPKSVVFYQDKHQGINDKVMQMSQQLAMQWRLRAICSPSYCEEFLINNKPLPNWDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5V9</accession>
    <name>A0AA38L5V9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_386963</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041263839" description="non-specific serine/threonine protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="837"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="14">
        <location>
            <begin position="1187"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="658"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3786055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1321" mass="144948" checksum="B5BEBFD316DB2C7F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6A3</accession>
    <name>A0AA38L6A3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_350129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6A3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="429"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117094" checksum="ECBA1AB82ED2938F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6G6</accession>
    <name>A0AA38L6G6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">18S rRNA biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_348804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6G6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="181"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="364" mass="39673" checksum="490D002B898F0EE0" modified="2024-01-24" version="1">MAAGSVIQYSGHKCFRHRLVLSILSGKPVKIHGIRSEDKNPGLRDFEVSLLRLLERITNGTVIEISVTGTAILLKPGIIAGGPLVHDCPLSRSVGYFLEPVIMLAPFAKRPIQLTLRGITTDDNDLSADLIRTVTLPHLQLFGISDGLELRIKKRGAPPGGGGEVQFLCPIVKQVKTLNFVEPGKIKRIRGISHAVRVNPQFSNRMIEAARSILNRYIPDIYLHSDVYKGEESGKSPGYALSLLAESTTSVLFCSEATSEPGVAPEDIALQATRALLSEISKGGCVDQKHQSLVILLMVLGSEDVGRCRMSQPTPRTIQLLRDIRDSFGTYFKISPADPTKPDSSDLLYSCYGTGYVNANRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6H9</accession>
    <name>A0AA38L6H9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_288093</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6H9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="176"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="406"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3787525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="536" mass="57978" checksum="658C933D2B39FB85" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L771</accession>
    <name>A0AA38L771_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_344622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L771"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="69"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3789055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="279" mass="31509" checksum="7BD4427ABD01CCB3" modified="2024-01-24" version="1">MAPKLYQELEKYVTDLEKKASSFPPQLLVVSAFAAGAIASIGVVRIHGRSFKRIQNSDWITPESFEKKRWIKGVVLSVGDADNFRLYHTPGIGWTWPLKFRRVPPTPKEYKNRTIHIRIAGADAPEAAHFGRVAQPFSEESLAWLSDRILGQIVYCQLIHRDQYARIVANVVTKRRFLPGSLFGESLALQMIKSGWATTYEQAGAEYGKWGKEEFLKAEIGAKALRLGMWKDGIQGETPAEYKRRHAQTENAPVSKRASAKSTTPSNSSRSFLNKIKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBK8</accession>
    <name>A0AA38NBK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_411736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793558">
        <property type="protein sequence ID" value="KAJ3781441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBK8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="296"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="377" mass="41001" checksum="445082C4A6AF1EEC" modified="2024-01-24" version="1">MSSTSSTFVTLTYKTCGKVPIKLDVYPPTATITIARAKALNEVPAVLWFHGGGPIVPISSRNGSRRINDAGCAFVSADYRLIPTGSITAHHILEDVKDAFAFLRSERFEGALDALDIGGNLGFPKFRIDPGRIAAGGSSAGGTCAYFAAAHVQPKPAAVLSVFGMGGDVLNSQYLAPKTEPFLKGRPLLDPNRSKDYIYPFSPSVASDILSDSPLAFYPPTATLPALPANPRMPLALLYIQLGTYLDYYTGEHEPSLSDTLRAVCPSLDAEINPGMKKIILQKHVPTQHHAVFPQLNVSASWPPIFLLHGAEDTAVPIAESKNLYRMLKHWGVQAKLKIVDGEDHFFDQDPDAEQKHGDIFDEAASFLIEKLHHRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBN5</accession>
    <name>A0AA38NBN5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793533">
        <property type="protein sequence ID" value="KAJ3781681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041369234" evidence="1">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="282" mass="29185" checksum="9DEAD949C37FDD7B" modified="2024-01-24" version="1">MRSWFTLYFIWVLLISVLWASAHSVNGRDEDPEAEDTICAYVPHKQLQRRATDDSGNGTDVGVGVDVPSLGLTLGNITTKLGNINLTVTNVTISVGNIDIENITIGNISIIVSVPLPGASPINAFSASTASQSITSSTASATSTISPSTTVSQSSAGLFRMKRQDSFTGLTTITPTPTSTSDVGLPNPTVSASVGGGPVGIGAGNVDTEIGNITIFVGNVNVSVGDGTAFLFLYLKVTILIEDNVYKVNIKNVSVGNIFVLVQIGQPDLNGAIGNLTSQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBR4</accession>
    <name>A0AA38NBR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_365318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793516">
        <property type="protein sequence ID" value="KAJ3781891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="280" mass="31066" checksum="8EBEA9E4AE853264" modified="2024-01-24" version="1">MSNNRDRVTSSTFHKPKQRVLGGGSGGNWRAANVAPAWRTNAQSDGMNTKKGQGQGQGQEVGSKILLSHLPSDVGEGEVEELFKKTIGPLKESFVIYNSQGRSKGMAVVVFQRPGDAVVARTKYNGKFVDGRRPIRIEIISDHSDPITIPPGRFPPNPHNSHVQSKHPQPLSLLDRIAKPRQAAAAALIASQSQSQSQFEPYAALSPVASLRSSLPSHPRKRTKKGPKRLNKSRVEFPRYMNTTTNGTDHVKKVHKTKEQLDEEMEVYRAEREEYDQDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBX2</accession>
    <name>A0AA38NBX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_275927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793488">
        <property type="protein sequence ID" value="KAJ3782266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBX2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="994" mass="112852" checksum="62253E1A23F33724" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC45</accession>
    <name>A0AA38NC45_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_297179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793449">
        <property type="protein sequence ID" value="KAJ3782866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC45"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041353683" evidence="11">
        <location>
            <begin position="22"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3782866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="545" mass="60960" checksum="4F15A3F15957AC6D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCA4</accession>
    <name>A0AA38NCA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_361215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCA4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041487636" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="620" mass="68179" checksum="B4A1F57E79816A7B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND59</accession>
    <name>A0AA38ND59_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_311564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND59"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF5">
        <property type="entry name" value="DEPENDENT EPIMERASE_DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="323" mass="34606" checksum="5C4FC59E2F9C6EA7" modified="2024-01-24" version="1">MSTYIQNKLVKGEKLQFFITGASGYIGLAVTEYAIAQGFSVRGLSRSEEGDEKLKSLGATPVRGDLNTHDVLARESAAADAIIHLAWNHDWSADYSKIVDADIAAVNAICAAIKDTGKPLVIASGCAGGQPNADGSETDENAPLRQNFIVAKRLESETNATAKEGIHGIAIRLSPYVYGHGGKGFLLMQIAEAVKLNESLYINDGTYHTSTLHVEDAARLFIAAVLKGKAGEAYNGVGQTDVSLKDMAEAIGKVVGVPVRSVTPEEAAQKWSPFLAMFNYLDVRSSNKKAREFLDWKPEGVDYITDIVSGSYAPVAAQLKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDD2</accession>
    <name>A0AA38NDD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_266316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDD2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041282351" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="387"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109236" checksum="5CB1E1BB7A082132" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHM0</accession>
    <name>A0AA38NHM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_118931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793589">
        <property type="protein sequence ID" value="KAJ3781202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHM0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="418" mass="45837" checksum="C1ED50501732428B" modified="2024-01-24" version="1">MCKFKWKGRKRSKSDVGALSEKLTLPGINYPKFSALKRAKSQKLFVSNDDDQSGTLPTIPASPPTLTANLELDPNPTSPSLSVYTHPSDVLLPAAPRSKVERTIGHAVPAHMLLSANDMTDYGPIGRRNRRRSRGSTHSLSSLSSTTRSNRRGSLARSLSSLGSFIRLSNSRPSSDVYIYAEEDTNDVDAGVMEDDDKEEVCWIDNEYDSYSREGAITPISPMIFSVRPPSPTPPKLKLVTDSVGLAETSASVVSVSSEAEGHEHSELDSEDEDENNEARSELPTPATTPNDSTVSDTPLSLSCNAVCDAVPPASPIVFSEPECLPFSPRSDSVELETSENTPRAQLKTFLSEPMTPPSSIAPVTPPVSVSPFQSSFLFPNPHRREGREEREMRPQGWTGEWNRKDVREVIRSLRELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIG8</accession>
    <name>A0AA38NIG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_272702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="109"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="39796" checksum="12086D9FDBFBDF02" modified="2024-01-24" version="1">MYASEKLMNFRWIAKVAATYSPYILSAKDLADQKLFSELAEIGQFTELAYTNAVPVEFLFKNLNILMRSKFPLQGYDALDDSVLVSEFFGKVAHLHGYVVYRPRTKQLVVATSGTSTAVQAIQDLRTLWHRHKSHRGLVHSGFWQLYKGIRSFILEGIRKGFEEHEDIEELVITGHSMGAAVSYILLLDQILVSDDILPANIPIKLVAFGSPRPGDANLARYYQELIGTYRGKYGDAAFSEYLVKAYNDGVPALPPLFLGYRHFTQTPLYYDHMCLYHIPSSESEYTLFHVDAEKSPEYPRGGHNYYNGRDQERLLRRLGWLEKSLTKDEIHWQESYLERVQKHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIW0</accession>
    <name>A0AA38NIW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_145242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793738">
        <property type="protein sequence ID" value="KAJ3780438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="163" mass="17523" checksum="7C060BB4759786FB" modified="2024-01-24" version="1">MGPKLLAKLVHEGNIPVTTTLQGLGAFDETDGKSLHMLGMHGSAYANIAMQQADVIIALGARFDDRVTGKFDTFAPATRAAALQGRGGIIHFEIQPKNVNKVVQASIPILGDVVTNMASLVPVRWSPLEVSVPWALVFLPPSAPKLPHHKKWLSISTVMLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIW5</accession>
    <name>A0AA38NIW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_280300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794233">
        <property type="protein sequence ID" value="KAJ3779779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIW5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="293"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="597" mass="68263" checksum="69130E82FCD39145" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ47</accession>
    <name>A0AA38NJ47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_418234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793852">
        <property type="protein sequence ID" value="KAJ3780214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9764" checksum="608083E311F2B2E3" modified="2024-01-24" version="1" fragment="single">IYVLKWPSKSPDINPIENAWAELERRLHKLHPAPRSLTQLWTAIETIWYSAEFNEYVIHLYASFPRRIQGLLDKKGRWLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL63</accession>
    <name>A0AA38NL63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="9">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_346376</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="9"/>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL63"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041328579" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3788357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="474" mass="49895" checksum="C82449AA100C19C1" modified="2024-01-24" version="1">MKTNPVLQLWLAFGSLSVLAQSSEWGQCGGIGWSGAQTCVSGTTCTTINAYYSQCLPGSNPVSSSSITTVPPSSVPPTSVTPTSPTTTATAPASPTGACSTPLTLPGFNNAALPNPFLFNDGTPVQTKEDWTCRRAQIAALIQGYEAGFLPPKPSTLTGSFSKSGNTGTLAITASNGGPSISFSSTITYPSGTAPADGWPLIIAYEGGSIPIPAGIAVLNYANSDMAQQDTTASRGLGTFYNLYGSSANASAMTAWVWGVSRIIDILEETPTAQINTQRIGVTGCSRDGKGALMAGAFEPRIALTIPQESGSGGDAGWRISLYEQNQGSVVQTATEIVTENVWFSPSFNNYVNNLNTLPYDHHSLLALVAPRGLIAFENTDYVWLSPVSAFGCETGARTVYQALGVLENHGFEQVGGHAHCAWPSSLTPALDAFINKFLLGQNVSTDEWSSNMVFNGVTWNQAQWINWETPTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMB9</accession>
    <name>A0AA38NMB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_267073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMB9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="403" mass="44592" checksum="E71F183C3F4E45E5" modified="2024-01-24" version="1" fragment="single">DGTIIDVIPTKIDMVLSSVLANKAFARDAMSELLKFSFNLLLHYPKACISDATRTSPSSRGQQDFQSSNLDGLLPSLLRVYRSLPRTFPIPLVPPLTHAIHALVTIPITHSLISLWLSTTRNSTSRQLRSSHTPRPRSSSTLDRALNVFTAGRRSLSISSNSPASMVGNSHRDIVVRTMDLLEIVFSFHFPSNSNPDSREIREAFKNVLAGSGMSTDTSLDELVSPLLLLCTRICMMDHTSRKRVREWIIPPSLDRSYPLDERDDFLGRCIRLLGSVYHTRLKASVGEMLYAACDCDPSILSSLVGYGHVAGFLFNKGILSAPPPPSTDPHSSQRVVNPITGTYDTMAQNGMNNSIVEMTEEEKEIEMDKLFVLFDRLDRSGAPPTNQGKAVHSTVKSKRTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMF3</accession>
    <name>A0AA38NMF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_266462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="411" mass="47279" checksum="0F2251F7D54C2D1D" modified="2024-01-24" version="1">MSSLSSVVSDLVRASMGTSISPTVTDEELDKHVRDLLIRDAKKRAERYGQQGIRAYLASGLSDSNAPRANKRFLSSVIRSTDEHNKTILRAQALSAEEIKRERREQEMKERRARAEEAVEAERLRRSGSIASRRRANDSEVWDRSDGTRSDRKRKKRNWETWTGEEDEDEDNHEGEHHRSRRRRTSRRSRSRSPHNDRESYRHRHSSRRSRSRDGRTSSSKIKKHRSRSPPPRHKSNGDTRPSRSTRRDREREEPKYKRRKSSRSSSRSSQMSISRSPTPGPDDSGPARPSKMDRYFEESYDPRLDVAPLSAAPKVPATGLIDSAEFEGWDTMLDLIRIRREDKAEKKRLERMGLSKDEIKKTMFGDPNAVGTAGGGSVSDRWAGEAISSMNIQYSKRGSVREWDMGKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNG8</accession>
    <name>A0AA38NNG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_345247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="80" mass="9399" checksum="0A64CAB90E25D7AA" modified="2024-01-24" version="1">MFEEAEVSMRSQIKILEDELERQNVLLAETKKRYMREAELLMSYIHGMGMNTMRGHLGQRPGKTAWLTSQRSNSRLQRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNM1</accession>
    <name>A0AA38NNM1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anticodon-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_390909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793614">
        <property type="protein sequence ID" value="KAJ3781025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNM1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="124"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="42781" checksum="F14A5859A1DD015E" modified="2024-01-24" version="1">MSSSRFEPSTIKNKIKREEIANKNRKTKSQSKLQRRLARAKLEANDPAAKKKRLSTNVPRTLDNMREFDPSFLTADPSSSTQTQADHDPSTSSGEPAYDENAEDIASDPFASYFNSEEDPNLPPKVLITTSPKASKSTYDFCDEIVGVFPGAEFIRRKKGKGFEMGRIAGWAAGRGYKHMVVVNEDMKKPNAITLIHLPNGPTAYFKLTSIELTKQIYGHARATPHNPELVLNNFVTRLGHTVGRMFQTFFPPLPEFQGRQVVTLHNQRDFLFFRRHRYAFRSPEKVALQEIGPRFTLKLRSLRKGIPAVFNLAEEPKGLEFDLEPEPKTEENLGTDKHEEGASEVLEKVLPPKQDEYLWKWKPELETTRRTFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP26</accession>
    <name>A0AA38NP26_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_363020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793459">
        <property type="protein sequence ID" value="KAJ3782690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="147"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="405" mass="45987" checksum="517E42EE246F1269" modified="2024-01-24" version="1">MYSFFGSSKKENTETPPNTAGTTNSTLSTKSSKSKKGSDSTQMEDSPKQTTTKILTEPAPGTKTGPIHEYDENQKEMMKQVKEYALSISLPSSDPYAKWERRWLDKPDTIPRYSRASKWHLNDAKKRIKNTLEWRREFKPELIVPDEVKIEDESGKIVINGFDKDGRPIIYMRPGRQNTETSPRQLRHLVWCLERAKDLMPPGQESLVIIVDYKTTTLRTNPPISVASKVLTILQHHYVETLGRAIVTNLPLLLNFFYKGISPFLDPVTRDKMRFNPDLLELVPSSQLEAEFGGEYEYEFNHEHYWQQIIETCGIAPDGTRVNEVIPELDNEEAGEPKQPISDQGRETEEEKEEGTEEEEEESNTSTPATAVDSLTPVTPAAEDVAKRVEEMSISMSMEAQTITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP39</accession>
    <name>A0AA38NP39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_429279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793447">
        <property type="protein sequence ID" value="KAJ3782885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP39"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="295" mass="30820" checksum="4DC3F9E1BE8E7EA6" modified="2024-01-24" version="1">MSPIDSEAVVQHLIAQTRSNISFLISQHQISPTSGREILDRLPNVGVSIPDPVTALSEQASNFQISGPSTPPPTSYGIRDHPATASVKAKAVWGYNETGEDPQDLSFRAGDIIEVVQETNNDWWTGSYNGREGLFPSTYVEKLPPSSPLSRPPPSPAARNNPIYKSNPNNAFHGSSYSDTSPLGPPAAPNPTYLTSYAPTGPPPRGPSPSRYGPPPSGYYQSPPPPQAYNSFPYPPGPPPPGPVVVSASAPPAPLDQPKKSKFGGMGNTLATAAVGGLGFGAGSAIGADVVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP80</accession>
    <name>A0AA38NP80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_51423</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793416">
        <property type="protein sequence ID" value="KAJ3783500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041276215" description="CFEM domain-containing protein" evidence="14">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="15">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3783500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="153" mass="15010" checksum="798FD8180D17A085" modified="2024-01-24" version="1">MKFFVAVSILSAFTSTCASLISRQTFPSCSQACLANADLGSCSADDDTCLCNTPAFISSTASCIADSCTGNDLTEANAAAQDLCLAVGITLTASSIPISTSTTPASSGSASATASTTAGSAAETSSTSNGALSNGMNTFASLTVFGLIATLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPK4</accession>
    <name>A0AA38NPK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_375858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPK4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17815" checksum="7353B9C994648813" modified="2024-01-24" version="1">MLIPVTFDAQSSSSSNTQKLPPSLAKISHDEVVLLDLQGALELESTHPNERDGKLVGTLSIDNDLKRPILRIGHHLIEGNLVNLPKPLAVLHRSPVSARISNSQWAQENTNREDEDVAMDSQEESFESILNSPTIQWNALAIVKRKILFSKRPMPVVGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ83</accession>
    <name>A0AA38NQ83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1690-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_92998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20237" checksum="B00B4E1C686D394F" modified="2024-01-24" version="1">MGASQSRSDNGQVVFRSETPVQFSPDVVEQLSERQVSATPTPERQSTLDEHVRTRIQNEVKHLRKAEEEIQQEIRLALEKENLDREKAMAGQVSDEHGAGAGSVKSSAALMGDLEEIRSKIDRFQTRRSLANYPGLKASQEALVSCYKTHPTSSLDCWKEIANFKNSVAQLEKDYFKTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQI5</accession>
    <name>A0AA38NQI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQI5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="226" mass="25418" checksum="34E8F91264F955FB" modified="2024-01-24" version="1">MESTDEGHILHWSFCGTHILFPGLRLTSFETFTAASLLVSVICFSERFVSFIYEQEWRPPFIARARWQNALWKTALYWIMTLLRFLYMLCAMSFHFGLLLVIVTSLAVAHLLVEIRRDIQSSDTRGSYTSIEPFHDESPDLQLPPARLRSKSKPDSIFIHPQHSNIARADAAALQLGLGGPTERVSGSVYQLREEASWKSGTGKDVARALLGTSRHNGGSDSDSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQN5</accession>
    <name>A0AA38NQN5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_405342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="480" mass="52854" checksum="C5A7901A944E5FD6" modified="2024-01-24" version="1">MLAKPSSNLSPYLSTRETSSFAQSMSECTRKRKRQAEDDDFDPSNPQSQDEKHKTRRINPYKLAERLPSGLVKEMETFIEPGAIMPNFDIRKELQIRYQVDRRHIYDYFHSRGLRVAKEDRHSNLTRSRIAKAKAQVQVQCDDGVKENIPFKFTNPVKVLPAKRSSSKPKNARKSVKRPVVTMTEALVLCDSSQVQDTESPDVKSFELDNDEVDSVDVSLSNDIDAFADVVSEVVESSPCFYSENASVSSSRSTPSLVDDSSSSCKSPSPGVVQPEEEPFSAAEFAAEFLNLPEDSESQDYSIDTTFDLSFAPSMIGDLMCPSDRKNMYEHIDTNIVSTGTSFALDLSALQPDTTNHSSLLTAAALPPLLPSLSLDSYIKALQTIASVIPNAVPACQTLLPTPMSLPATSNGYSLPATLSNSTYVLTPSDFLTPGFRQADSFSFSPPGAPYTSTALYTSTDPFHHALQNEQRTVHTGRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR99</accession>
    <name>A0AA38NR99_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_38972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR99"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="119" mass="12781" checksum="1FA260C224AD6F48" modified="2024-01-24" version="1">MSHLVDVLASLASSENNVAAGLGETLQAFVVAASLYPSAEPILIEFGHRTMALGRKRMATMAGRNAFVYVKGKFGLLNASTPLFLQAVITGKADGAFVEIDLDAWEEIVPYIVKLRIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRC1</accession>
    <name>A0AA38NRC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_343015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRC1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="194" mass="22108" checksum="C4C0B71E45A21690" modified="2024-01-24" version="1">MGSIRPLDASAGPMVWIDCEMTGLNPEKDKILEIAVLITNGNLEIMDEGVNYVVQTEKHVLDQMDEWCTKQHGSSGLTNSCLSSPYTREYVAKAVLAYVKRWVPNARTAVLAGNSVHADRSFLVKELPELVDWLHYRIVDVSSIKELARRWYKSPSQRTPRLYESDHRALSDIRGSIKELEWYRQNLFVAPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRF6</accession>
    <name>A0AA38NRF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SNF2-family ATP dependent chromatin remodeling factor snf21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_33056</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
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        <property type="entry name" value="Bromodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SnAC"/>
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    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
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    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="15">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="14">
        <location>
            <begin position="334"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="516"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="828"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="1234"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1114"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1329"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1329"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1373"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3789753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1384" mass="157698" checksum="5B315EA9033F8570" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS76</accession>
    <name>A0AA38NS76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_282761</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS76"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="137"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3790172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="404" mass="45590" checksum="4541CB12E46D8F31" modified="2024-01-24" version="1">MATVGSVTRQIAALELSNKKPGTTTTSARPTLHSKQSSQTNVAKLLTKYAAPNPPNASVFSTKLTKSATAIAILPSKARTHNVSEAPTLDIGNYDGGLELENEKRGEKVSGDAAQELALDSSSAQISPTREWSLHNFDMGRPLGKGKFGRVYMVRTKAEPNYILALKTLYKSEIVAGKVEKQIRREIEIQQNLRHPNVLRLYGYFHDEKRIFLMLEFAGKGELYKQLSKHGCFSEKRSSRYIDQMADALSYLHSKHVIHRDIKPENLLLGLNGELKIADFGWSVHAPGNRRKTMCGTLDYLPPEMVEGKEHSEKVDYWALGVLTYEFLIGNPPFEDRKSVNNTYRRIMKVDLKFPPGMSAEVKDLIARLLQHEPQDRIPLTDVLRHPWIVKHRPKDCNRGSEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS87</accession>
    <name>A0AA38NS87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_341311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="387" mass="42390" checksum="415FDB9852916F08" modified="2024-01-24" version="1">MDPDRKSTVSSFYGGRRGSQDALNNDFPSSYGPNYSNHAQGRGRDDASSFFDPDRTSRNLDGAGRASTAGYNRGSYFMAGREEPVKGGRDEEEAGGNGGAWDIYADFNNEGPRYSSAFVSSSTPTDAYHPLVQKEEAPSTIGPVEMVTVPAMGPEWQRDELRDMTKAGKREKKSESRQQAWKEWNRGQRGICGKWFTRKMLIIFLFTLCCCIGIILAFTVPRVPAFAFNTSTPLANATGDWKDAIPTVFSRSPTNFSFAGFADLQVNTDSNFLPLTFNHLRATIYDLDTGVQVGSGDLGHRTFPAKTLSSFQLPLNFTYSAVNTSDTTWTNWYDACRNAVDDVGGVRPAVKFTIKLDMDIAGLPSKPSTQAQVSNADCPVELAENAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSF8</accession>
    <name>A0AA38NSF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_392131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSF8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3790306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="126" mass="14331" checksum="A74DB5F67C254075" modified="2024-01-24" version="1">MSTPPPQVNVSSLSMERYHQLSDEAMDMLLEDLEQLIEDHGDPSFESGVLTLRLGDKGTYVFNKQPPNKQIWLSSPFSGPKRYDYTESDGSWRYSRDNKPLDDLLNDELGRAFNKSVQLSLSSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSG4</accession>
    <name>A0AA38NSG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_258903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSG4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="185"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="34477" checksum="2E6F2F980AF7C1D8" modified="2024-01-24" version="1">MVAGYSSSAGAEAPLIINPSQLRQSLKGEQQVTVLDTTWFMPNSPHKAYEEFQKRRIPGAQFLDLDELASSHELGLKHMMPSGAQFAEACEKFGIQPSTHVVLYDTHGVFSSPRALFMFRSLGHINSSILNGGLPSWNAKSFVIDTNPPSQPPHKSKYTLPKPDQNAVRSYEQMVANSASNPSTSVEAELVLDARSSGRFTGQDPEPRPGLSSGHIPNSFSLPFTSFLKTEEGVRGSTYTVFREPSEIRKELDNAVGAAQAERIIQGEATAVTTCGSGMTAGVVWLGLKLLNAPKISLYDESWTGYAMRPTSKIEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT23</accession>
    <name>A0AA38NT23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_392025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="62"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="156"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="453" mass="49937" checksum="099DA2D059FEA32A" modified="2024-01-24" version="1">MSTHPVVELTSEASWAMVEDKFSPYAKETLAKLIEFMENEILPAIKVAHAQLPIDPNMRWKTVIPIIEELKVKAKKLGLWNLFLSKAHYPEFGVSLTNLEYAVMAEILGRGGHFAPQVVNCSAPDTGNMEVLARYANREQQQKWLVPLLNGEIRSAFAMTEKHVASSDATNIRTSLRREGDEIVINGHKWWISGAGDPRCKVHLVLGKSDPGNKSAYHQQSIVLVPADTAGVKIIRPMKVFGYDDAPEGHCEIIYDNVRVPVGNLVLGWGKGFEIIQGRLGPGRIHHCMRSIGAAQYALDTMLRRVTDPAKKTFGKYLYEHGTVVADIAKSRAEIEGARLLVLSAALQIDKVKAKGALKEIGIAKFVVPSMALEVIDRAMQSFGAEGLSQDQELASAWAGLRTLRIADGPDAVHIQQVGLKELKRAPALVQKDMEIKRKQALLMEKAGVKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTT7</accession>
    <name>A0AA38NTT7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_103212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTT7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041214637" evidence="1">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="151" mass="16717" checksum="4A975E93D94B8202" modified="2024-01-24" version="1">MFSRAIVYAFLTFFLAGLATASPLPMPLQFGRRNGLGPVDTIEVYRRENLAVRDHGIQYLPRQIPTENAVKSPDGTIVPYGKRQIPTEQAVKSPSGTIEPYRRTIPEEIAVKADTPGNIVQYREAPTRARRSTIPVESPVKALTPGDIVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTZ7</accession>
    <name>A0AA38NTZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_65966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in 20S proteasome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 20S proteasome chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTZ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3791124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="256" mass="27975" checksum="D578A641AA217947" modified="2024-01-24" version="1">MPLLNDTLRSNLSGKTLITPIVSTANVAQLSVDLLISSLGLVRIAALDSRYFIPLVGCRENGEPGITTPFELYGKEGLDVVVLQQRSPTLKARKQEFINDLFDFVRESGIASVLILTGVDLTNRLDEQMLTPTYQLQPIASSLSSTPLHRLNDFPIPKYTSPVLQKPSAINDETQIPFIPGGGITRRMLSSLPKTWSIPLAALLRFALDGDNRADAYSLASIVVQVIGIDLGSVEWKQPESWSGLFGTPHDQSLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU23</accession>
    <name>A0AA38NU23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_301445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="483" mass="53034" checksum="AE308E4DCE5C1ABA" modified="2024-01-24" version="1">MLLSDLPNDIIIIVLRNFPVSDLGALSRTSRLFYHLVNTYGWQIHIRCNPRPSFSLTKAREIWHPRIRLQYDTLSDKSWSTSHFVARPLSHPWPRKQQSILAINNTRLIVAAGNTIYSYAFGASRASGSPPLLFEGSFSLHEERNSQWDITAMTFVHDNGDGKTLLCGFRNGTLARVVLVKEDASNKLALQIDMEVDLYSHTPDVVESISASGSLCLSLSSRGQARMRNIQPTSYTSISEVDLATRSWTTYMSDESSPYVAFGSSSKIAPLSVYSILEGSFSSTPTAILGMKSSQPMSHSAVYGICRSPLSSPWGASPQILISGWFDGVVRVHDLRSSLLTEHLSDNSNSSGIPTSAAPLRPVMSLNDPWSIEPVYSVSSGGGACSHLAAGSARHSVVSFWDIRYPKSGWSVYAPGNDPSPVYSVVLESSRVFGATDSRPFVYDFGPNVTHDTYPQLTPSPGLKPRRSVPGYYVTRYSHGHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU58</accession>
    <name>A0AA38NU58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_338178</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU58"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="208"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3791214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="687" mass="77126" checksum="7636D9C25D6FD52A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TY68</accession>
    <name>A0AA38TY68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_343675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TY68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="228"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="36588" checksum="E28F1DB11D8748FD" modified="2024-01-24" version="1">MLERIVYHTVAIALTILDGPFWLYDRYFQKPIRLPEHEFWSDDEIIRAVDSASYLDGTDERLVKISENTVVKFCHDWETTVPESLAMELVYMQTRIAVPRMKRVLQHHHAEGDSLIVMDFIPNSRRLEIAWPTLSMWSRLKIILTMRLYLRQIRRVQHTLSSNVPGPISSTPLPCSGLQLSLDPLGPFPTVSALEAHYRKQIADAEYYASRGWSRSPKCKPLPTSVFTPLVFTHNDLNMRNLLLDDRGVLWIVDWGFAGFFPPWFEYLGMLYAAQKDDNPESWQHCIKYMAEPNFEVEEWMQKMGYGFHHPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYR4</accession>
    <name>A0AA38TYR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_283784</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3789732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="531" mass="60390" checksum="3EDCC459E67400B3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYY3</accession>
    <name>A0AA38TYY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_425412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="37778" checksum="24722450EA6A4B4B" modified="2024-01-24" version="1">MDSLHPTQKGLCNLPGDSEKVIDADEEVFILYTELQAQDYQSLPSSTMTSFRGLGHVDSHQDIVFLKFPLINPVAGSSSASAASNTSSELESSKSRRRARKKRDTHRPDVIELEIQIAQDKTSLRSRKGDTGSVVWRASVDLASAILQDAHFPPSIHPSLLDLSKLRNAHVLELGSGTGILGVALSPFVHRYTCTDVHDLMPLIHKNLVLNFPEWPHECNISLTALDWTELHRTSLSNRSRFFKFDPVDLLLIVDCIYHPSLIPPLLATIDYMTIPDVTTVLVVVELRAEDVIREFLSCWLNVPAWEIWRIGNGERDIMKRPYAIWVGIKHRSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZ14</accession>
    <name>A0AA38TZ14_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_259676</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZ14"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="192"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3789865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="686" mass="73583" checksum="8AE52E616C494D9A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZ71</accession>
    <name>A0AA38TZ71_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeodomain transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_259548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZ71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF41">
        <property type="entry name" value="BRAIN-SPECIFIC HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="276"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="471" mass="53232" checksum="026EAC0648A6D393" modified="2024-01-24" version="1">MKDKQKKPRHRHSPAQLIALNELYERDEHPALDLRVNLAERLGMETKTVNAWFQNKRASSKKRTLTRSTAPYDNPSINSLTPPSTSSFRRNDLDELDEEIDAQSPPLLDNGRMGSPFYTGNNENAHFEEQDNMQRRSRIRPSPEQVEQLKNLFNANPLPSTEEKQALADRIGMRYQSITTWFQNQRSILKKRQEGDTDLTAASFPNTEYPFDTPARRYSAFPPPTHHPSLNLPPANSHPSLPSMPARGRRSLSPDPASSRRINRRSGTPYDSVLNSRPRRTRPEPYQLDALKDMFLKTAHPTIEERTTLAIQIGMDLGKVTNWFRNLRQTTRKRAKKTGSGDDDYDDYDDDVDYPDHDQDASTSRYGSPSSSTWTNDDSVMYDEKVPMHSGSVSDAGSDDEYEEAVTPSSESSRSPPPLARSPSSQVNLSNLTSAALESATIAEMDKVSYKSGIKVEDALLLLTFHHQVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZH7</accession>
    <name>A0AA38TZH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_425734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="8">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="8"/>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="57"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3789268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="497" mass="56821" checksum="BB6D8F2E8601FEBE" modified="2024-01-24" version="1">MSTGLEAPPRVTLSLGHLPSKKNIKAPWPRTPTRIDPNNPPWPAFRGYHEYSFAHATMQSRLPTILGKAIDDTTRTLNEQSSEDKVIDLVQCIERMETLMTDLSGNAKLRPILDDNEADVALWNKEIAKYFQGKDFMNAPWLFAEAYKYRRLRECFSISKFWSDYDVFYRQKCDTFSRSADAVFELSLRFAEPFTISDKLSAQEKLEAERLMFLELTQVCLWGNSTDLSLLINMTEEQIKALQSTGGDHLAATEKNILGNHLGKLWDTVKELREKTNGRIDFVLDNAGFELYCDMVYADFLIQSGLATEIHFHGKRYPWFVSDVTKKDWEWLLNTMVYGQLFPKASDVELESLRRLGGRWKQYEKEGKWVYEQHPFWCTGYTFWDLHSEAPDLFLHLSRSDLVFFKGDLNHRKLTYDCAAPASTPFEIAIGPMANSAGAPKIASLRTIKSDVVVGLGDEGDEIAEKLDDEEPGWKISGKYAVVLLSEGRPGEKVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0G7</accession>
    <name>A0AA38U0G7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_302937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0G7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="628" mass="67842" checksum="C8410A6622FB6FF9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0L4</accession>
    <name>A0AA38U0L4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_340116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0L4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="106" mass="11871" checksum="88DE14756CAAA446" modified="2024-01-24" version="1">MFSLSRRCLQRTVQIRRFAATSYVSNADATSTQGEQHIRAKLTEKFNPTSLQVQDISGGCGDFYAITIASDAFKGLPMVKQHRLVTETLKKEIEGIHGLQIQTRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0Y9</accession>
    <name>A0AA38U0Y9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal subunit protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_391704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0Y9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="50"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="208" mass="23700" checksum="B6097C7B753236F8" modified="2024-01-24" version="1">MLDYDFDDDDTTSAGHLMLREQRQTLYYLRLIEHEMPKLVAYRKPFVVPKDSPLIVRSLEYGGEDHPATSKRVVVVAVDDLPMTDKHSVHKIKLLAGPRWSLKPPANSGVSDLKSWGNGFIKISCEDFLHPAQNLKWISDTLDRLIGEANNKKDTFADVPQDVRHIYSVARKAKLGEHLRGRVHARPTIRDFPQDWLPDKPISRPGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1L1</accession>
    <name>A0AA38U1L1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_338284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1L1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Septin-type G" evidence="8">
        <location>
            <begin position="28"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="681"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="713"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3791245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="805" mass="87885" checksum="70F0CDCA08AD8CB0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1P1</accession>
    <name>A0AA38U1P1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_340847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1196"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1349" mass="151552" checksum="3BD506FAD865D401" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U2E0</accession>
    <name>A0AA38U2E0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_391855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U2E0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="381" mass="41407" checksum="22F83C3A17433EB0" modified="2024-01-24" version="1">MALFVTTVSCVVFASFAILYQVYLSPLLTVLGTFRTVQTFGLNVAACTRIPELQACEKIVLVRPSGLLYLACSTPESRLAWTPGMNQLNAEGRSSDDYVATYDSTTSKVARLRLEDFDSDQPISVHGMDVVSSASNASELFVYMINHRAPSGQDPRKVGADSVIEVFKATVSENRLFHIKTVRDPAIVSPNDIAGLADGKGFYFTNDHGSKAVYSATTSVGYCHIDHGCKIVASGLPSSNGILKASSNDTIYVSSSFGGKITVFKKREDNSLSLMDVISIDQVLDNLSFDNEDRLWVAAFPRARDIKELLSKNIDHATPVAAFRISSNIGPSSNGEKYKVEKVLEDDGTIVSGSTSVAYDSDRNLLFMHGIVARQLTVCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U6D2</accession>
    <name>A0AA38U6D2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_341858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U6D2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="19558" checksum="DB341148B7C7E04B" modified="2024-01-24" version="1">MSNVGNKVKGAFNTVHGIGENSIRATALGAVDTIAHDKEGEVKNDQIAQQGRMETQRGMEQMSGRQQNTNTMANNYNTTTADPALANSTIANTTANPSTSDYPRHHRDNEVYNDSQAQTVYDHGNNVPSQAGYTNAVGGVPEPSGNTEYGAGYGAGYGVGNNNVVDPRQDVGNSQYDNGNRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7Y7</accession>
    <name>A0AA38K7Y7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_232928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793614">
        <property type="protein sequence ID" value="KAJ3781014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7Y7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="118" mass="13386" checksum="D8CC65DC4B2041D3" modified="2024-01-24" version="1" fragment="single">NDVNAANKLLLSGAIVSNKRVEAAKTMKEEIRCFKCQRFGHIAERCPEGDKITCGKCGEEHSTTDCYSEKRHCVNCGIDGHASTDRDCAAFQRRCDSLNRRMPTNQLPFFPSNEEWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8U4</accession>
    <name>A0AA38K8U4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CPII coat sec24 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_70110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793450">
        <property type="protein sequence ID" value="KAJ3782844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8U4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3782844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="937" mass="103131" checksum="E85EDAF79D935832" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K979</accession>
    <name>A0AA38K979_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_435734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793405">
        <property type="protein sequence ID" value="KAJ3783759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K979"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="36833" checksum="D1446700DAF455EB" modified="2024-01-24" version="1">MDISSTPISTSVKSPHVVLDLWYPDGNLILENEDSIFKVYSGLLAQKSTVFRDMFTFPQPTSSQEIPTVRLYDSTEDLTWFLKAIFDAEFFEPPPSTTDLSIVGGILRLSSKYDVQFLRKRAMLHVQTTYPSTLKAWKRRDTHRSIPPVDNSPFAILPLVHEFELDWALPAVLYCLCSYNVDQIIDGVTFRTQHFTLGEEDKRKVLIGRAELVHLQNKLSFRCLRSPPHRDCPSRTECAEQFRKWLDHVSSWNMADPLDYLDENWESLEEDLCLSCIAQSKNDTQVTQHEIWEKLPQIFKLQSWTELKVLEDKAMDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9B5</accession>
    <name>A0AA38K9B5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_377208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9B5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="13210" checksum="2BE6D15AB19C1A64" modified="2024-01-24" version="1">MSFSASTNNAQAPHSSPTSALGKKWYREESNRDDSSSSWKEAKNTKKNRSNHLLSQSSPSSSGQSSTNPAGDANNAPADSFPNAINRPSQHSSSPATSRKVYHIFQKDLEEATGGVARFKVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAD7</accession>
    <name>A0AA38KAD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_353268</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041343332" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="128"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3785964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="222" mass="20976" checksum="BEB5AF6E5BE6E065" modified="2024-01-24" version="1">MQFTLSLLHLVSIAVVSVSAQDSTSASSIDASSVASSVASAATAAASGLSSCSLACITQAASAAGCSSTTDLDCLCTNAQFQEDSLECLTNQCPSDLETALALQTAECGALGLSATGTATSGSFSATGISTSSSGTESITSSQASSTSTSASSNSAVTSGSNSGSATSSKASTSGTSSTSSASGSTTSSSSNGADKVAFWSTAGVMAVGVVVLGAGLGNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB42</accession>
    <name>A0AA38KB42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794570">
        <property type="protein sequence ID" value="KAJ3779593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="110" mass="11794" checksum="6D1C448AE382671C" modified="2024-01-24" version="1">MSTTSSPAHPVRSPTPVLNKEDVELQAFLAAAQREAQEKWEKLRAAKTSGVVGKVVEGEAGVVGSKENVVEGVAEEEEEVVPKVEPRPQKVVAKMVVGLPRSREVIPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC72</accession>
    <name>A0AA38KC72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793582">
        <property type="protein sequence ID" value="KAJ3781258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC72"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="98" mass="11194" checksum="67987F7A54B22F74" modified="2024-01-24" version="1">MEYGLVFFFSSCVFCVSVFFVSLSVCLSVYVFCSFVRLFVCSCYAICFPLLLPSFLYSLPTYLFRKNSQIIPSSVFCLYLVFLVFSPSLQISKFSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD91</accession>
    <name>A0AA38KD91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_416116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="MU793741">
        <property type="protein sequence ID" value="KAJ3780431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1876"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="2048"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="800"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="851"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="860"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="895"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="2284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2284" mass="254328" checksum="3F643FA7CDC96BBA" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEM6</accession>
    <name>A0AA38KEM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_387334</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793337">
        <property type="protein sequence ID" value="KAJ3785578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEM6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000965">
        <property type="entry name" value="Autophagy-like protein 18 Atg18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3785578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="419" mass="45319" checksum="DDB0F914C6C4D439" modified="2024-01-24" version="1">MVERTNSNMLFANFNQDFSCISVGTRKGYSITNCDPFGRVYTMNDGARGIVEMLFCTSLIALVGAADQPQSSPRKLQIVNTKRQSMICELLFPSSILAVKLNRKTLVIVLETEIYIYDISNMRLLHVIETTPNPEAICALSPSADSSYLAYPSPVPSPSTSGTPTINSVPSSSSFAPQSGDVLLFSTRTLTVANVIQAHKAPISFLSINSTGTLLATSSDKGTVIRVWSIPGAEKLYQFRRGTRETKIYSMNFNTVSSLLAVSSAHDTVHIFKLARGKESSNNGKLSSPSPSSDSVDTVEGGVDGGYEAFIEKKKNGGVSSSLRKRSLQVTKTFSHSMGGYLPNTLTEMWEPSRDFAFLRLPTSGARCVVALSGTMPQVMVISSEGYFYSYNIDLENGGECSLIKQYSLLDSGGDPSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEV4</accession>
    <name>A0AA38KEV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_405144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793430">
        <property type="protein sequence ID" value="KAJ3783221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="467" mass="51197" checksum="B75EF7614F237A8B" modified="2024-01-24" version="1">MSSNSCSPDVPPFHGYVETTVNALRLIHAARQGVIPRITRRLNDTERRSMIKSGAVFIFSVEESGIKRWTDGLLWSPSRIVGNFLVYREINERASSRGNHKKTYTGDDSRNSPIHRNSPGLSSGYKASSSAQSGSDQGTFKPNGLIKKTITVTIEGSDLHLISYYTSEDIRNGRLKRPSSRPDIMGLYMPPHIFRLTNFRVPPKMEMGPDGKHRLVPEPEEQDVDCKIEEQTYGSPTSSASPGHSPVDHPLNPLYPLTSANVGSSFAYSRAGDRWQGTVDTTRIGTPALQSQDIWPLSPPSSHTHIGGSRRETGGLSQSESWISSGLQSGKSRISVIHELASPDRFIERSRARSSNPYQNAVAMRDHENLPGLTTRYSGSRIGRDSGSQRLPWMMSPDSSDRDNRSSHSRSSYSSSSSSALPFGEGYQSYGSGWSGNDHGIDIPTSQTPFSPSHQTYTSSYTAGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF27</accession>
    <name>A0AA38KF27_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_352864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF27"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="64" mass="7532" checksum="2015432AFD7F020D" modified="2024-01-24" version="1">MRRSAQIFYHFWVDLCSFEIFIPVWSYPLFNQLKPNANYDVTHARVCAMRVHVCTALSVVLVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFJ7</accession>
    <name>A0AA38KFJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_418720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFJ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049509">
        <property type="entry name" value="DyP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF4">
        <property type="entry name" value="DEFERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21105">
        <property type="entry name" value="DyP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041217000" evidence="8">
        <location>
            <begin position="21"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="DyP dimeric alpha+beta barrel" evidence="9">
        <location>
            <begin position="64"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="527" mass="56083" checksum="D4015D34CDA586BF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFR6</accession>
    <name>A0AA38KFR6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_401387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793373">
        <property type="protein sequence ID" value="KAJ3784541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFR6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1081" mass="122711" checksum="F17D41CAAEF67710" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG06</accession>
    <name>A0AA38KG06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="1">FBP aldolase</shortName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_356010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG06"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="300" mass="32950" checksum="DDA79C7B2E53C3C1" modified="2024-01-24" version="1">MSFEGLQGNRTLDILHKAEQGRYGVLAQVCYDAQSIIALVRSAERMSSPAIIMLFPVTLAYGKGPFLQFCLNIAHQASVPIAVHLDHATDPEHLELAFSLAKEGIAFDSIMVDASHAETDEENIALARPYVERARRYGIAVEVELGRLEGGEAGLRMISDAKLTNEKNADMFMKGTGAVILAPSIGNLHGSYLKPPNFRQDILKNLRTMFKGRGIPLCLHGTDELPDELFRDCIASGISKFNINSWARDPYLENLTTSLRAGKPLPDAIEEATEVFAKVCDRFIELFGSAGKAQLETQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG11</accession>
    <name>A0AA38KG11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_348426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041490204" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="673" mass="74034" checksum="CB57C98CAF189328" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGU1</accession>
    <name>A0AA38KGU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_345374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15103" checksum="F6CEBC68F4FD1B3E" modified="2024-01-24" version="1">MSLKFWKPGTAGPGSSLDRDTQTEENVVQCAPAYSSLSIQSQRERLPIYKHREKLLYCIEKYGVMIVVGQTGCGKTTQLPQYLMEAGWASEGNVIACTQPRRVAATSVAGRVATEVGSLLGDETECFSEKHWWTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHW5</accession>
    <name>A0AA38KHW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial 50S ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_393336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHW5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="223" mass="25642" checksum="CBB0815C6ACECB23" modified="2024-01-24" version="1">MQRGLHKGNSASTYNPLNWLRQKLTADRREKESKKEILAAKEEAREEGQLSLFEQTKAIVPTTEDSAAKLSVPSPKHKYSTTYFKMSPRKLNMLGNQISGKPIDYAILQMQFSEKRASKRIMNMLATAKDHACRYKHLDMSKLVVGEAWVNKGKVLKRIEPRGRGHMGIRKHKQAKMHVVLKEGMSIEEKKEKERAYKLKKIVSAATVRENRPIRNPGSMWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKJ1</accession>
    <name>A0AA38KKJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793803">
        <property type="protein sequence ID" value="KAJ3780299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="118" mass="12947" checksum="E386821CD2C308C5" modified="2024-01-24" version="1">MSITSSPAHPVQSPTSVLDEEDVELQAFLAAAKREAQEKWEKLRLVKMSEVVERVGGEGGETIEAQGNVEEDVIGVEKEIIPKIEARPRKVVARMVAGLPRNREVIAVSLLLSIPEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKQ4</accession>
    <name>A0AA38KKQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794164">
        <property type="protein sequence ID" value="KAJ3779835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="125" mass="14128" checksum="6AF0DB926A0DA514" modified="2024-01-24" version="1" fragment="single">MRKWSVHNLNPIKAETYIIPNCRATPSDAGAIARCSRGGKGRGGACEARQAAEERKKKEEKELAEKKCRIEEAKRAKAVKKKLEEAEKKRQEELAEARMGKAREVVPSQKRVRDDISDPLDPPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKR9</accession>
    <name>A0AA38KKR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_278984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793677">
        <property type="protein sequence ID" value="KAJ3780659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKR9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28387" checksum="F0D8F5957E3B165A" modified="2024-01-24" version="1" fragment="single">SGNRGATTAIAWIIRPDDAEEGLVFGTDDGYLSVWRQERADSFIEISCERLVGGPDGDEISGIAYDASSGQLGVVQRSESVHRFIIDPSMRPIVVRSVKIPRHWPQAVAFGQTGVRGPELWSFGREDGVIHVLNDEGKVLKSRMTGSVIGHAAINVKEDALIIDDVSQGVAVYKLSTTDRVKTFEVPCMTRKLRFVAFHDGNSAIVTGSDHGKVYIFDRRTGNIIDTIYIGVDDWVQSIAVRGRERARIQADWPHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMR4</accession>
    <name>A0AA38KMR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793990">
        <property type="protein sequence ID" value="KAJ3780006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="300" mass="34911" checksum="A8DDE0AD771ACE60" modified="2024-01-24" version="1">MHSNAKASGSRRRLDDDGDDERRRPRKRMEDRKKERLARLRQKLRMRKATVRKEEEKEQRDEENDEERRNKLPPVEEPPAPLASRLDFPSDHWVEPSEEHLDLSPSYPDNRVSVMVPPLPPSSPSADGPVIGAPRIPRCANCKLGARVGQPCIVQNARNRCTSCARRRIKCADDETLAARNARSAKGERIGRRSRKVVEEIEEDDEEDEDQRVVSKVPRRGLRDRYPREAQSLEDRILIETRRIGEQQEMTLRVMDRMEERQERIESELARIARILEAKENEVNEESEGEGNEEKNNEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNU6</accession>
    <name>A0AA38KNU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_357481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793372">
        <property type="protein sequence ID" value="KAJ3784544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="152" mass="17240" checksum="7185F56B32E5D83A" modified="2024-01-24" version="1">MIDRPVRERVFFLDDHDYPQLLPKPVSTRRRPVSMITDMHPNGNPPFPVPSPVRRLSVHRPLRSSPLAGPALSSEGLVIPDEDNQRRCKPSRISSSPELPSVSSYSSIYAKDCLSSPHLEIAPRPRLNQRNSSPSYLQSRTNKDGQNFERFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP61</accession>
    <name>A0AA38KP61_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793549">
        <property type="protein sequence ID" value="KAJ3781521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP61"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="679" mass="73055" checksum="C0CD0B9DCC18A0E7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPC7</accession>
    <name>A0AA38KPC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793529">
        <property type="protein sequence ID" value="KAJ3781731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
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    </feature>
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        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="515"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="931" mass="101793" checksum="DD10921FD111569B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPM5</accession>
    <name>A0AA38KPM5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_397070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793506">
        <property type="protein sequence ID" value="KAJ3782016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPM5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="613" mass="69418" checksum="5D11FB369DBCB578" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPU0</accession>
    <name>A0AA38KPU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_354176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPU0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041400340" evidence="2">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="258" mass="28860" checksum="DCBA5CF6A272DD14" modified="2024-01-24" version="1">MQLLLRPVLFIGLFFLVKIFATPVCTRAGTGSGQVFSSSDPSSGFCNVGKVPANNSPAIHARALDGRKEVIKTELYLYAPQWPDESHISEDFAVKFYNAAQMILPLLVPVHPAARRLNIPENLAFDVTEFLYYGSSDNEEFKLSVYLYHNDEVISISIRFDQHAFFESQSLRAEDLSGHADCNNCFVFGDGFYQVPGRRPIEFPELKITKVTAVKTREPHNIIKFTFEKDRKSSRSKKLLQKFKDKTGGRGGAGPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQZ3</accession>
    <name>A0AA38KQZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_316073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="2"/>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQZ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="5">
        <location>
            <begin position="122"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="6">
        <location>
            <begin position="251"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="383" mass="43091" checksum="57C1F769A2FD5804" modified="2024-01-24" version="1">MYWLPKCRQKHLPRVKFNFHSRRTTSSSPTWGDQFKILFLGRDEFSCLVLQELHRSDVWQEIHLATNPDEKVDRGSRLSVSPLKIFGHSIGLPVYTIPPKSEFKNWAIPPPFTNVDGPPYPQHVIITASFGRILPFRMLKLFAPERRLNVHPSLLPAYRGAAPIQHAIMNAERETGVCVTKMLKRSEGIDAGPIWGTRTMSMLEDISFADLRDKLAVEGGQLLVSVLRDMMTGKAVSKPQSQTNISYAPTISFKDATLDFTTMTAAAIVQTYRAIGHQRPLTVYLPTIKTLQMHSPSVHTAPPPYTPTVPGRACYSKPDKAILIRCADNSVLSVRKVKQEGRALLDAREWWSGAKSFGLVVDNEINFDSQDDVDQWLQPEFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR34</accession>
    <name>A0AA38KR34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_290573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793318">
        <property type="protein sequence ID" value="KAJ3786285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR34"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="156" mass="17861" checksum="367C9E18C7B8AEC2" modified="2024-01-24" version="1">MSVYFYEPSYSWDRLFDEAFGSRSSRHGQSHQSQRQALTDKPEMSRFLKPKMDLHEDQEKNLVTATFEFPGVNKEDVQLNMHNGRLTVAAETKVSQDREQDGYAVRERSFGKFSRTLQLPQGVKEEDIKASMEHGVLTVTFPKASAEQTPKTITIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRC0</accession>
    <name>A0AA38KRC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_289941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRC0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="532" mass="60490" checksum="792D7CF1A3D7CCCB" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS47</accession>
    <name>A0AA38KS47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_432314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="272" mass="29784" checksum="53D4744F862B3D14" modified="2024-01-24" version="1">MATTSSANRNNSAVKRIMQEARELANDPSTDYTAAPLEDDIFEWHCTIRGPAGTEFEGGLYHLRILLPAEYPFRPPSLMVLTPNGRFELNTKICISFTNYHEELWQPAWGVRTAILGIQGFFPLRGQAAVGVGSIEYPSAERKRLATLSRKWTCPHCQQSNLELLPDPSSPNTSATSYEMQPDSVMELPTAAVTVTSDAAPSPPFHPEPNLGSNVSDDGVLRTDSAPTPIPVPPAVIIAPQTISNFRPPVFLDALIGIILALVFALLFKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS84</accession>
    <name>A0AA38KS84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="325" mass="36330" checksum="8689EDEB7B4781C0" modified="2024-01-24" version="1">MPGPSNGRKKRKSGGKTQRKKFTVNVTHQISHNTITNASFENAQYTASASSPPPSSSYVDVTTRIYDATDEHNQPQQNHQVEYPIQHFDQPEYPIPNTPSNKFNSHLLLQEPYIHDPGNGPRVRNTRAFLKSRYFSQPPALDDPLCAEFAQEEVLQMLKTVLPEELALILWYNKSRASSRICPACQRLYHVGEVLPDHATLTGGAKSEMKPLQPPELEREQGLSGFCSSMCFILASFNQCDPRTTKAAWGHSADEIDDESWTILNGGSPLILKEGPGQNVAKALVMIVRMTRLDDLGLAQLCFPDVNWEGSNGSKEDLREEVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS89</accession>
    <name>A0AA38KS89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_195489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="523" mass="55407" checksum="1336D552B5A80CFB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSG7</accession>
    <name>A0AA38KSG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_268496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18258" checksum="613927895FD1AE43" modified="2024-01-24" version="1">MRSSFVSPSVLLDEVNGEAIPTRRERSGTIGTLSSAFSSSTTDSTNSTTNSSPERQSLAKKKRRSLGLTLGTVSIGNISGIRSPTIGTARGKKRKLVISGIEINDTRAYQAVKNWCESFGELKKFERRDNGNLVVDWRSKSVNDMVCRVQANVFIKGAGSVALSWIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSK2</accession>
    <name>A0AA38KSK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_291390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793329">
        <property type="protein sequence ID" value="KAJ3785886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSK2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="34833" checksum="06B5C4EB7BFDE87D" modified="2024-01-24" version="1" fragment="single">MASSSKPIEILFKHVDGIDIYMDVYLSPSSSQQSPAPILLWWHGGGLLQGTRKGVSPHHLRAPASHGVTFISADYRLAPQFRLPTILSDCADAVKFLHTQQFQKATEGRADASRVILSGSSAGGWLSLLCGYRIGFDEIGVPKPPSVQGVVPIYPITDLEDPFWTTTQRPVKYMDRVIALEEVQPFLNPDEPTSRIASSALDSPRAIFYSFMVQEALLADLLLSGTEIPPSTFSIAGSLKTRKLDCPPTYIVHGDQDLKVPVKQSRDVVQALEELKLKGNADCEYEYEELPGLDHLFDREPKSQMEKMYAFIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSU8</accession>
    <name>A0AA38KSU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794242">
        <property type="protein sequence ID" value="KAJ3779772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041438516" evidence="1">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="212" mass="22993" checksum="D3B8BE6CA59431AD" modified="2024-01-24" version="1">MSMVSGAEIVLLGFCFFLGSLGAGLEVELDLDLLSVLLFLEADFTDTGSGGSRVFEDPILTSYFFCMQIITHKPGLGPQAQAFTKSSPSPEPSQALLKGWAFLGWVGLGWTHCKDIEGIPGFPIISHIAQGCATEKDTIKVLEALDEVLGAETVAVIEGSTRKSYTVLGSEVGLQQSFWQCSLHAIWVSLQSAEKNKALEHQTSLIDRFRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUS3</accession>
    <name>A0AA38KUS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_344383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="211" mass="23608" checksum="A8CB84386836A14A" modified="2024-01-24" version="1">MHWPLDYKWFKMDVPEATYDPNNSKPLTLTFSQSNGFGKPATLNIFWEYKYKSTWTGTQVKRYSIKDPGGPIEWMPSTKSYHGSFNTTYTLNKTIELIDLTDVDLSISIGATPNDWKTVAVPDEGDGFWGQIGQIFGGSYNPGDIPSFVRDTTMDGISFSFSFGKLRFFSVTNVLLPGEKVIEVNIQNGLGMPRDCVIVGNIVQSRASRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV40</accession>
    <name>A0AA38KV40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_296403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV40"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="243"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="438" mass="45728" checksum="88D25103A017CDD5" modified="2024-01-24" version="1">MSQSIQLSEINRSREATHSQSSISNEVTLNHTHSLVDEMPEGGYGWVVVASCSVIMFFSVGGFYSWGVIQAQLAAESIAPNSTLAFIGSLGVSFIAFGAIFMGRLIRWVGARNAGFLSCLLMGGGQILSSASSKNVGGLFVTNGIIVGLGTSMSFMLCSTLPSQYFTQKRGLANGAVFSAAGIGGAILSVVQSALISRLGVAWTFRIIGAAIIALTFPACCFLKDRLRRSTATIEWSLFLDPRFVMLALGSAIGTFPLLVPPFFLPLYTNSLGLAASAGSILLAVFNVSSAIGRVSFGALCDICGPITSLSLALILSALSLLAIWPVSNSLAPLMVFAILNGFGNGGFFSTIPSVVAHMYGPIRVTTVFSMVLTGWAAGYLLGAPIAGWLLDAYGGSGGGIVAYRPAMYYAGSLSVGSTGFILGVRILTTKKNLFTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW36</accession>
    <name>A0AA38KW36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_7305</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793348">
        <property type="protein sequence ID" value="KAJ3785247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW36"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="515" mass="59150" checksum="D8FE1A8C06DA6163" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW73</accession>
    <name>A0AA38KW73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794036">
        <property type="protein sequence ID" value="KAJ3779948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW73"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="119" mass="14694" checksum="43A406847AFC410D" modified="2024-01-24" version="1">MPRKRTPSAILKSERTPEEKEAAKARSRHLADRRYRRKLKYNDPDKAKERMKKKRSERTEEEKARDQERRKVYNGTYYLKKREDILDKQMKERARVYIEKHGEQSFWNSYPHRHVNRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWX7</accession>
    <name>A0AA38KWX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_310443</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3786702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="395" mass="43055" checksum="7BE4B08D06347A59" modified="2024-01-24" version="1">MSTTNSHSQEPLKNVLVTGGAGYIGSHVIYTLLRTHKYKVISIDNYHNSFPAALTRVSELALTELKAASDSQPSAQDIDSTAIDVHECDLNAASAVRSIFSSYSSKGGIWGVIHIAAYKAVGESSEIPLTYYANNVAATISLLQTMQEFGCMRLIYSSSATVYGVPPDIPIKEETRREGDSVYGRTKVMCELIIQDFCDSVMNDSGSKTSFQAISLRYFNPAGAHPSGYIGEHPRGRPENLLPLLAHMAVGTVTDPVLKVFGNDYPTPDGTCVRDYLHILDLAAGHVVALQALEEGSELNAKVFASSIQSQGRFKAYNLGKGHGMSVMQIVDAMRKATGHDYKTEVIGRRRGDVPELIADPALARAELGFDAPRDLETMCRDLWNWQVKNPTGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX02</accession>
    <name>A0AA38KX02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_310220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX02"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="277" mass="31011" checksum="1D2D3658B36E2803" modified="2024-01-24" version="1">MIVLKDIPYHRGPIRDPFREFDLYYQKSSDLALLPLICFVHGGAWRSEDKLDHSNLARNLVSATTIPVIVPNYRLSSGSNDVRHPNHAEDILELLVFITTTSLELPRVFDPSKIYLISHSCGAHMLASIVLDSASIFPTLTPPSTVLNAIQGIILSEGIYDIDRLRLDFPAYHSWFITEAFNDKPSYAATNTTNLRLRSQSNIRWLIIHSKGDTLVNVAQSEAMFAHLQSLYGGLIGQTVWSNTDELTQEHDALLSTSTYLRIVVDFIKGANYVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYM4</accession>
    <name>A0AA38KYM4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_359813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYM4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="302" mass="34282" checksum="F3B3B27D1CA5AAF8" modified="2024-01-24" version="1">MSSPAMGKRALKYFDRSGGDGITWVTDPDKSSSAPIHMITDNTIRSILQLNADMASGKVSMTTTMLPEHWDVIVRAFNAEGLEEKFVVIRNDKTFDQVNMPAREATIFGEVTHTYQSSPTWSSISHSVSMGSEENEMRVDQMDHSTESFDATLPSFALQPTGSVITPSRFLTADPSTHAPTIPEDLRFSKITASADVNTKSQSAEPDPRPYSKREKLQNRAGPIRRNNRSHRAQVRKQYLQLKKQSEDSEKLLMRAKEVMYMKALRDHEAMKRNRQKKDEKKRVRDKERAPEEEIDDSSFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYS1</accession>
    <name>A0AA38KYS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_377077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793391">
        <property type="protein sequence ID" value="KAJ3784088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="243" mass="26307" checksum="85F40DDF798B96A6" modified="2024-01-24" version="1">MTSSHSEFKQTEQVVGRPRTTSHDMVDHYANDAPNKHAGGRLGALGDAEDGGIPLFEDRCDREADGMVDRAGVAINGGTEMGRPVPPQESGPQPHPYLHEPLLYITNLSANITDETLGMAFMTCAPFRPRITRDSASPMVSGTIEFKFLEKAEKALATLQSRPLPGVPGVLLMLSPYPPTNPPTPLPPPSALPRLVKHLPIGFGDSALYGLFRPYGALASVRIPTHFGPDTGMIEFWNEDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L077</accession>
    <name>A0AA38L077_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP synthase subunit D-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_348745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L077"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="254" mass="28222" checksum="EA1FA1821EFD294C" modified="2024-01-24" version="1">MAGTGARENVFATRMALTNTKLRLKGAQTGHSLLAKKRDALTTRFRAILKKVDEAKRKMGRVMQLASLSMAEVTYATGDISYLVQEQAKSASFKVKSKQENVSGVVLPAFEVDRVSGSDFNLTGLGRGGQQVLRAKEVYAKAIETLVELASLQTAFTILDEVIRATNRRVNAIEHVVIPRLENTIKYILSELDEMDREEFFRLKKVQGKKKRDNAARQLEQELVSEEAQASAVEGEQDEQAVDLLSSKDSDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0B1</accession>
    <name>A0AA38L0B1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_308605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0B1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="401" mass="47057" checksum="11ECB105BD79BB94" modified="2024-01-24" version="1">MTIANAFAFGVRIRIVVFFFCFNALLYMSFSVLRDDWRRLAAYHLYPSTSNVTSDDLGSDTVASNIVENVASSTVTSDLSPKPQFEGKANATLVFLARNSDLQGVLRSMESVETHFNHKFGYPWILLNEEEFTEEFQESVKSKTNASVQFGLIPSRHWYQPDWIDEAKAEQGRNALKAWNVIYADSVSYRNMCRFNSGFFFHHPLLQPYRYYWRIEPDVDYFCQMQYDPFDYLKDNNKTYGFTIAIEELERTVSTLWQAVKEFMEQYPEYIHPNNALAFLSDNGGETYNLCHFWSNFEIADMDFWRGEAYTKFFEFLDLKGGFYYERWGDAPIHSIAAALFLDKNQLHFFNDIGYQHSNIVHCPQQPAFLTGSCTCNRVLSIDYRRYSCLPRYNKMLNRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0D9</accession>
    <name>A0AA38L0D9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Eisosome component PIL1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_426512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0D9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="544" mass="57371" checksum="82221AC1A36DD3DB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0S5</accession>
    <name>A0AA38L0S5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_393036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0S5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="38"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="427" mass="48125" checksum="103E4CFA9A1A9F41" modified="2024-01-24" version="1">MATAERSDLVRFSDRLKHGRALAEDVWSIYNVANLPADCINLGQGYMNFAPPEWVTNAAKEALGTVAANHYSHPKGRMRLRQALKKVYDPQLERDLDVEKEILVTSGANEGQYAVFTAFLEPGDEVIMFEPFFDQYLASVTFNGGIPIYVPLHPPVNATGRFSSDEWKINPKELRSAITPRTKMIIVNTPHNPVGKVFTRAELEVIAALAKEHNLLVMSDEVYDTLVFDGKEHVRIATLPGMWERTVTVGSAGKSFAATGWRVGWLFGPEYIMRPTLAATTRIVFCSNSPLQEATAVGLEQVQERKFFETQTAQYAERRDVLTKCFDSLGLPYTDPEGSYFILLDISRVRFPDDYPFPESVLGRGRDFKACWFIAIEIGVSSIPVSEFYCIEHANIGEVYARFAFCKDLDTLRHAAKRLEKLKEYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1R8</accession>
    <name>A0AA38L1R8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglycerate mutase (2,3-diphosphoglycerate-independent)</fullName>
            <ecNumber evidence="4">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_230267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="4"/>
    <dbReference type="EMBL" id="MU793755">
        <property type="protein sequence ID" value="KAJ3780397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1R8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="246" mass="27516" checksum="28E6E410E02A9758" modified="2024-01-24" version="1" fragment="single">IVWQDIVRIDLSIKKKQFHTNPVILSSIQRANSGSGRLHLLGLISDGGVHSHINYSYAVLQNAKAQNVRETYVHFFGDGRDTAPHSAAGYREDLVGFMKREGYGELATVVGRYYAMDRDKRWKRVSIAVDGSLDDSLNIPVPKDLHITTMSQYNPTFPLPTASPPQSMSNMLAETLSLQSIHLSHIAETEKYAHVTFFFNGGIERAFPNEHRYLIRSPKTPTYDQSPTMSVAGVAQKVADLVRQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2V2</accession>
    <name>A0AA38L2V2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_363593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793471">
        <property type="protein sequence ID" value="KAJ3782512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2V2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3782512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="77" mass="9214" checksum="194354CB696FF0A6" modified="2024-01-24" version="1">MTSSSTTASREEMKAAKLPLGWRDQCSALLIPLNICRREKNFLPWECEHEKHAYEKCQYDDYMRRMSELSRRKSEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L476</accession>
    <name>A0AA38L476_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_362055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793440">
        <property type="protein sequence ID" value="KAJ3783025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L476"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041416302" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="186" mass="20176" checksum="1C26FB3B96FEB4FC" modified="2024-01-24" version="1">MKVSNIVFASASLLFVKATPAVTKREQIVCPGQVTVSETFIGAENNVKLAQVYCPENTVPTLSARQDNGTALDVCGATCETNCFTPSGGGPDPNDCTVIADAMRFYSQNVNDTFYIGTGTNNTVVLTYSTCETFYVNQDPVEQSYCYSDWASIVDYIAPNCQSTQNAHGGNCIAEDQQWFIQVQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4A4</accession>
    <name>A0AA38L4A4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_296601</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="MU793434">
        <property type="protein sequence ID" value="KAJ3783145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4A4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000608">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="971"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="971"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3783145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="995" mass="112238" checksum="2A65180DC7569219" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4M6</accession>
    <name>A0AA38L4M6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_316301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793407">
        <property type="protein sequence ID" value="KAJ3783715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4M6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="12">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="551"/>
            <end position="552"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3783715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="633" mass="70569" checksum="8E0BB406BD3D7ABB" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L526</accession>
    <name>A0AA38L526_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Voltage-dependent ion-selective channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_23693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L526"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="291" mass="30558" checksum="71CFE975F9B5185F" modified="2024-01-24" version="1">MSLPQPVPPSWKDLGKSSNDLLGKDYPFSTTSLEIKTKANDVSFKVAGNNSGGAIIGDLEAKYGNRKHGFTLTNTWTTANVLKSQIELENQIAKGLKVDILSSLAPEKGTKTAAINTAFKQSGLHTRASLDVFKGPTFTADAVVGRDGFLLGGEASYDVTGGIITRYAAAIGYNAPEYAVTVHGLNNLRTFSASYYHRVSPDVEAGAKAVYDSKATTGGVALEVGTKVYLDPAAFVKAKINNVGVIALGYTQALRPGVKLGLGLAVDTQKLNQVSPSGPAHKVGASFTFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L552</accession>
    <name>A0AA38L552_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Capsule structure designer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_418753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L552"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="62442" checksum="0215D52A5297956E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5H6</accession>
    <name>A0AA38L5H6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_355243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5H6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="397" mass="44434" checksum="2536550DE32AFC14" modified="2024-01-24" version="1">MTYTLTETIAPVAQPDICYHPDEAKYKQRTARRLAENPSLLKSRLPSGFPSKVEGPIVWEGKDWTSQDQWVFHLTPAQLQEIDDGLAYFKALNRPMGYISKDTFPLPTLSEILESLANELYSGRGFFVLRTIPVDNYTRSDLAIIYAGISSHVGSARGKQDGTGAVLAHIKDLTLSHAHEKGGIGNAAYTTDKQVFHTDVGDLIALIALATAAEGGVSRISSSARVYNELAATRPDLIKTLSEPWILDTFGGQPSYTSRPLLYHEDGHIIIQYSRRHFTGYGNQSRSSDIPPITEAQAEALDAVHFLAEKYSLGLNFQKGDIQYINSLGLLHARDAFRDDPEHVRHLIRLWLRNDKLAWPTPEPLQPIWKRLYSVDSDDQRFPLEPEIRRKANGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5L6</accession>
    <name>A0AA38L5L6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_434424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793337">
        <property type="protein sequence ID" value="KAJ3785575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5L6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041485085" description="Hydrophobin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="109" mass="10652" checksum="4EC65909A5D80C16" modified="2024-01-24" version="1">MQFKLAFVSAALATLAVATPAPRNEPASSCTTGPIQCCNTVESANSASAAALLGVLGIVVQDVNALVGLDCSPITGVGVSGSSCSAQAVCCDDNSHGTLISLGCLPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6L8</accession>
    <name>A0AA38L6L8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_229886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6L8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="62" mass="7373" checksum="C563C41A7F771E6F" modified="2024-01-24" version="1" fragment="single">ILYRGLDPVLGVFTGFLAYYLHENHPRTALPQEQRLIELIRWKWLKWQNARNAHLNAAETTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6V7</accession>
    <name>A0AA38L6V7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_346171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6V7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041406221" evidence="6">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="230" mass="25229" checksum="3D0D4D906DEB93D0" modified="2024-01-24" version="1">MFNSFLSLILFTINVVRAATLFVQDTPQTVLRSPETNIKVPVILGVMSRCPDALLCENSMDAVLKKVGDKIDLKLVYIAKVNSSEPDFGATCMHGPEECAGNVQQLCAAEYSPFAKWWEFVHCNNYQGRNKIGLPETARKCAQTAQIDWETSGVGECAGLDASGKGAEGVRLLHKSIAFGKTMGLEKSCTIYINGEKVCVHDGTWKECENGHTVADFTRQINEAYDKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB53</accession>
    <name>A0AA38NB53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_397864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="MU793894">
        <property type="protein sequence ID" value="KAJ3780136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB53"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="10">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="10">
        <location>
            <begin position="116"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="436" mass="51176" checksum="4E388EC10D9EF3EB" modified="2024-01-24" version="1">MDLETRIINGEMFVFCCSIFDGKDLFSFYLNDFNNDEELLIAAIKTLFKRNNFDSIFLLKILSKISLRIVPIINDNDLIDLTVKFSDKYNIKFKDSYLLLPSSLRKLAINFNVEEKEETIKYCNNDVIEFNLKIFSETRINAIKYPTLSSLAFAIYRSNFMKDEYEIKKIYGYYGGAVDVYIHKSDINQLVYRYDVNSLYPYVMKNFYMPTGNPQYFEGDIYLIKNKPFGFFEVEVESPKYLEHPILLFKTIAPLGKWKGVYFSEEIENAKKYGYKFKVLREIFMEYVDKFYDLKCNANKNDPIYIIAKLLLNSLYGKFGMSPYKDKHDIIDNKNLYKFVEKYIECDEDFSNNPNVNIAIAAAITGYARIFMSKFKNSNNFSLFYSDTDCIDIDKPLNKELIGTEIGNMKLEHVFTNIIYLAPKVYSVRNKGEAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB64</accession>
    <name>A0AA38NB64_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793854">
        <property type="protein sequence ID" value="KAJ3780211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB64"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1202" mass="133609" checksum="9EBAB6DB26B56FDA" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBL4</accession>
    <name>A0AA38NBL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_246913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793553">
        <property type="protein sequence ID" value="KAJ3781486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="74" mass="8496" checksum="51090300DADE0DD1" modified="2024-01-24" version="1" fragment="single">LYATPGYWAQEYHTSKLSGAQWVQELLVGHPDQIYTELGMHVHVFTAFVFELQLCGLSDSQYVKLDKKAAIFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBZ6</accession>
    <name>A0AA38NBZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exo-beta-1,3-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_408245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793474">
        <property type="protein sequence ID" value="KAJ3782461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBZ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041318186" evidence="5">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="78"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="421" mass="45873" checksum="E5E1718C7C8137FA" modified="2024-01-24" version="1">MAPSLLSTITIACSAVSLAVAISPGFSYGSEKVRGVNLGGWLVLEPWITPSLFDNTGNSAIVDEYTFCQLQDRATAQSVLEAHWASWITESDFEAIAAAGLNHVRLPIGFWAFDVGPGEPYISGQLPYLQKAVNWASNHGLKVIVDLHGAPGSQNGFDNSGQRMDYPTWHSNSTNVARTDAIIKTIADMYKDNPSVVPIIAPLNEPAGFDGNDVLSVVKQYWRDSYGNIRYPYGSSQQSNTVVLIHDAFQPLSYWSGFLTTSDNNAQGVAMDTHIYQMFTDAGNAMSDEEHIQSACGQKSTLSGFDLWLIVGEWTPAMTDCAPYLNGRGIGSRYDGSYPGSTAAGSCTGLTGSATDFSSSYKSSLRKTWEAQVITFEAAAAGWIQWTWKAENADEWTYQAGLNYGWIPQNPTSYEYPNICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHG9</accession>
    <name>A0AA38NHG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_369129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793694">
        <property type="protein sequence ID" value="KAJ3780587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHG9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="21204" checksum="F6C0FDF3FEDE2A68" modified="2024-01-24" version="1">MTLKVIMLKERKSTSIFRESRCLSPDKTSMPLSNITNVRNKAQTSIKSCSRSADSPTLMKKRKRVPRPSGSRFALSLKRNSAAKRTLSIKADTEKNAASQSTGIMDEKEIQRLMKILEETVEHVDDSKAEALHNLTSLSTSTIFSEFIGTPSSISPSASSTSLLSSSSTQSTVNANVMFSFTCDLCPEWSQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHT2</accession>
    <name>A0AA38NHT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_365565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793525">
        <property type="protein sequence ID" value="KAJ3781772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="291" mass="32124" checksum="FF53FD7F67130770" modified="2024-01-24" version="1">MASDIEEPQVVLITGCSTGLGRCIAEEALARGMRVIATARRLSTIEDLRDKGARTFTLNVDDKPEVLQSFAVDSINAFGQVDILINNAGWLLGGAIEENTPEEIQSQFNTNFFSVISITNAFMPHFRSRRTGTIVNISSQGSYLALSGAGIYCASKAALDCLTEAWSNELAPFNIRAVSVILGAFRTSVASSNSQAPTKTIEGYDFAHDFHKRFQERSGHELGDPVKGAKKILDLVTMKTEKPLPVRFALGDDAVYLSRQRLEQRISELDEWKSYGMDTNVEGMKYERANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NID0</accession>
    <name>A0AA38NID0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_360250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Plays a central role in virulence and antifungal drug action.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793410">
        <property type="protein sequence ID" value="KAJ3783632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NID0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3783632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="175" mass="19888" checksum="21E63671A7A2BC86" modified="2024-01-24" version="1">MGQSPSQFMEDMQRRSNFTQPELERLKKRFMKLDSDGSGSIDREEFLRIPQIASNPLASRMIAIFDEDGGGTVDFQEFVGGLSAFSSRGGREEKLRFAFKVYDVDRDGYISNGELFLVLKMMVGNNLKDQQLQQIVDKTIMEADKDGDGKLNLDEFAMMVSNTDIVKQMTLEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIS2</accession>
    <name>A0AA38NIS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_376759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793377">
        <property type="protein sequence ID" value="KAJ3784427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIS2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="50"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="161"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="447" mass="48089" checksum="9540913629300C53" modified="2024-01-24" version="1">MISRSRYVQTYRLGMLPLGYSFVILLAHPWSASSFEGSTKVARQTSIPSGWSFYSCFIDNTLSGRLLTVNSGLPSSTVTAVGCVEYCSSNNWTYAGVEYGGECYCDEVLHETGSQETSSSDCDMPCNGDTSQTCGGPNRIDVYWDGDLNVPSSPPTLYQSYWTYSGCFVDNTSQRTLITQVEPPSSSVSPPTCADTCAFYGYTTMGTEFGGCGNDTGSAAQVADTECAMTCDANRDYFCGDANRLSVYHNDPPQETYSSECLDLNVPSWLNISNFTLFASPKEPPTSSGGWEGSTLHIIDILVDGDATYSLISACQDCNVTWLGLSFSGTGAGYLIPSVSSPEGAPPMLSLNLIAGISVVFQTRATIPNDLPDYPNFCTIANPYPSGSGYSPTDGPVLQGDYHADAWAMCPNISAVPANRLDLVSQPQPDHPNYNVEECIPVDVWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIX7</accession>
    <name>A0AA38NIX7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793716">
        <property type="protein sequence ID" value="KAJ3780513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="181" mass="20615" checksum="DD8A33C04466A62D" modified="2024-01-24" version="1" fragment="single">KILLCKHLVQGVECVPPIFFLEVKRSRTAPVWSHPLLKPLHTENSDRGIEDAEKMDEITAEIEELELEDEGEGSDDEDEEGSEAAREISMQHLTYDEQMSNLVRSLHSFADGLAYQVQFRDDRMLDAVFRYGGSFVRMMEACLEKERRQNANSGAPLATWDAGAVSSMYYRSRPRRGEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ57</accession>
    <name>A0AA38NJ57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793630">
        <property type="protein sequence ID" value="KAJ3780918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ57"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="312" mass="36469" checksum="B11A433EF693E7ED" modified="2024-01-24" version="1">MTFFAGATNFTINYGRGETGPNFRHGDYIHHSSSTYSNESRVHVRRHDTPPWTRITMYDHTEREEYYDRDVETPHWINTQHNGSPATFSTSPNTQAHLSRASDYNRQYSRDRENYNQRREEYRQERERHRLEMERHRLEMERHRLDMERHRSERSYAQRENLHNFSINGGVFTVVGNGNGRSFGQSSFTNRRNNHSDSFRQHQEPRHSYYHSHPDNYVEEDIDHLPPGMFEQNPRRDPEVLYESPAPSYNERFSDPVLESGPNTSEFVEADGSGEAGGDSSNGEFSDSADVPLYTKDDMFPVSAYTEAGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ98</accession>
    <name>A0AA38NJ98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_320745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793596">
        <property type="protein sequence ID" value="KAJ3781143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ98"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="424" mass="47662" checksum="A884D655D4B4E7D5" modified="2024-01-24" version="1">MTPSKVRVAIIGGGIGGLTFAVALKECSDLQVDLYEQAHQITEIGAGITLWHRGYEILKSLGMKDDLVKLLNEESKDLDKQKLSFQYRFSDRKDGVEYFGLYSKGGARLFHRQEIQQMLLKHVPEFVTIHLSHQLERCEEGQDSVRLIFKDGFEATCDIVVAADGIKSVVRDSIPNDGVLPMGTNVFRGLIPREKLEKLYPDHSCLEHPTFLCGKSQYIVSFPISQGRTINVGACVTKLENEGKPLNGSGVRRSTTQEVLDLFVGWEDQAVQLIENMENPVCYALQELHPLKTYISRRIALVGDAAHGMTPYLAAGAGQAIEDAFILGRLFSEAGPENWARVFEAYNLARQPLGNKVQLDSRSQGFYLQLNAPEFENVRESRDLTHEQIEILRKSFTKHWSWLNGDVDQELTRASEFLNSAKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJD1</accession>
    <name>A0AA38NJD1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_115394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793573">
        <property type="protein sequence ID" value="KAJ3781323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJD1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF44">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09754)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="18391" checksum="E9FB89E5391CB4EB" modified="2024-01-24" version="1">MPVKLKGSCHCGAVKFTLESSTAVPYQLCFCSICRKVGGEGGSINLGGHSNTLNILQGKEYISVYNAVLNRDTPNEKIASSERNFCSKCSSMLWLYDEHWPELIHPFASAIDSPELEPPVTMVCIKLDSKPEYVRLPEGKKEIYDGYGKYSLEDWHKEHNLFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK42</accession>
    <name>A0AA38NK42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_276462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793508">
        <property type="protein sequence ID" value="KAJ3781984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="203" mass="23422" checksum="47FFF23730724987" modified="2024-01-24" version="1">MPFPRRIWGFDLTEMKWNAFKGKNMYDRRWHLRRERLIAYQIAMNICLAAECTATYSLSKYEDLQTHVQNYAFTLIPAYAVELHNDDLIAAEVLTIVFCVFVATLFGADLFFLVLWPRRTYPNWYNHTRLALAVGITAGLLAAALMSTIVIADHSAFITGAPVEMQQQYTDLFFRPPLKYNVYSVNIAYICLLWIGWVCTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKC7</accession>
    <name>A0AA38NKC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_406656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793447">
        <property type="protein sequence ID" value="KAJ3782883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="49129" checksum="BF6E0DAB2EA8A428" modified="2024-01-24" version="1">MIPDRCRHSAWSLNISTLRRLIIVCHDWYEAGIELLYVDIAVYWIEQLSSLLWTLQNRPDLAFKLLSIHIVCHVPPDHVEAFDLALKSFASICPNLTQLSAQFVHVHPSRYSRILPAFSGIPLTHLAIHSDDARSSTDLVYLFSESLISLALYARDALPTSSWTTRVDNSAGQSGQLRFPRLQYFQHDLEGYQLQFICFKWEFPALAYLACLKRRWNHSYLALADNLEFIRTHGRKISTLFLGYSIKDAHEYRVVEMIETLSGMTQLRHLIMPSFDDLSIPQIQCLDLFSSDNILPPISDLDSRFPNLKSYRLLDSSLFSLPWIYTMFPPTGQRYEFRYPGISIRADECSLRGTSSSERSLVRGEDLLFTSDSDSESDWVPSSDDDTGPDDDTQSSEHDTSGSDSEIDCEISEDEFDEYEFTSSIPPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL18</accession>
    <name>A0AA38NL18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_286984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL18"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="177" mass="20058" checksum="D3957EBCE8E7A70C" modified="2024-01-24" version="1">MSAAQHPMVVQAQNKAVYYHDQLDKELTKYPVLLNFEQRTQIPKTYAVLGASLLVVILHMFNPLAAPVSNLVGWALPAYLSFKAVESPSSQDDVQWLTYWVVFGFFNFLESFALRLVLYYVPWYFAFKTLFILWLQLPYFRGAQVTYLTVLKPVLANISNSAVVKQTEASAPAGPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL47</accession>
    <name>A0AA38NL47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_307377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="294" mass="32431" checksum="90ED1653D63FDBC5" modified="2024-01-24" version="1">MSESDSSSSSLQPTITEKSKSKTSTKNKSKTNSAANPTSEDDPTWAYQPPEGMSILEDAEVDEGWDWDTLEKDPELQLWVIRVPSGVKPKHLQNLAIDLSGPSSNRYTKVGALNRKQESYDIWNLGSSSTSDGNFIGGVEVGRTDVEAVAGGGEEIRGLTCLLPRKKKRGQLFIAPRPIARHLIISAQPIIPSSSDISTETATLTQNPPRFSYPQELLKHRFVAFGSTKNTNAEDAHYGDGDDDIQMEDVHMKSDKLTQKTTEKVSKQSKESKKRKKAEDAAMPTPKKQKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLC6</accession>
    <name>A0AA38NLC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_314919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793375">
        <property type="protein sequence ID" value="KAJ3784473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="241"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="392" mass="44748" checksum="1483E36AB55FEAF2" modified="2024-01-24" version="1">MLPSSYLVRCQLRHLPRTISQANAARSRFVSTAKNLQKKPDALQANTKKESVAAPSSATASSSSTDTKTLKSPTIEVGEDGLLHVPERPKSWLTHKVETSPTVRYWFMKITALLGYHSPKQRAGLRTFLLYERVCAVTPDAERSFWQNECDLPPTFQSWFIVTNLHFWMLTVRLRALPEPHGKFYVQFLLDHFFLDIEDRIRAILQPAIPPRDPYTFFTSFYVNPNIPKDGKLKRGSRAPERLVTRQMKIFKEQWMGMGMWFDYGLVTNDMELASAIWRNLLGARGSQGIAYPDSNPPKFRRGVNLVGGEVENPEKIDLEKEQGRDDGSGVHDYPPDEIDKYVGYPELMLDIVTYTRREIARLEKISDEEIMEGDLGALQFGKIRPHVKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM69</accession>
    <name>A0AA38NM69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_332612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793323">
        <property type="protein sequence ID" value="KAJ3786093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM69"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="18217" checksum="8AB3029DE9FA1017" modified="2024-01-24" version="1">MSEKNGFYSLKAEMPGNKVFDFADLKGKVVLIVNTASACGFTPQYKGLQTLYDKYKDRDFIILGFPCNQFGGQEPLDDAGVAEFCTVNHGVTFPLMKKSEVNGDNTNEVYQFLKSQKSGILGLTRIKWNFEKFLIDKQGNVVNRWASTSTPQAIDGEIAKLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMJ0</accession>
    <name>A0AA38NMJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_350183</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMJ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="365" mass="40437" checksum="BEE0F6BEC9A103D7" modified="2024-01-24" version="1">MTVGVKVRLHNHPSFPATWTFFSMNPPAVLQTPGFAHYSLAWSPFFNSRLALASSANFGLVGNGRLHIVSLVPGPGGLPTLKLDKFFESQDGLYDLAWSEAHENHVVTASGDGSIRLWDVTLDNLAIGVWQEHTKEVFSIDWSNIQKDTFISSSWDGTVKIWKPDRPRSILTLQAHQSCVYQALFSPHQPELISTCSTDGTLKIFDLRSPAYATGPSTNTFTNPLSAAVLTVPASASEVLTLDWNKYRPLVLASGSVDRMVKVWDCRMVKMGDSQVGGTCECSLPGHEYAVRKLQWSPHQADLLATASYDMTCRIWNTIPMGPQPPLRYIHDAHTEFVVGCAWSLYDEGLLATCSWDSRLNVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN21</accession>
    <name>A0AA38NN21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_172239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793946">
        <property type="protein sequence ID" value="KAJ3780065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN21"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="421" mass="48112" checksum="24B485320035BB2D" modified="2024-01-24" version="1">MATTPTRFPSPGPTPSKKAAAALAALNFDSPTKKPSKKVVIDDKRRSTSPASLEDDEDECNNDEAAEATPSKSAEDLTALHERFVGEVELPENEEPLLQESRRRFVLFPIQYHEIWQMYKKAEASFWTAEEMDLSKDLHDWNNRMNDNERFFISRVLAFFAASDGIVNENLLERFSNEVQVAEARCFYGFQIMMENIHSETYSLLIDTYIKDPVERDFLFDAVETIPCIKRKAEWALRWISDEHSVFGERLVAFAAVEGIFFSGSFASIFWMKKRGLMPGLAFSNELISRDEGMHTDFACLLFSHLRRRPHPNTVRRIIEEAVSIEQEFLTDALPVSLIGMNAKLMCQYIEFVADRLLVALGNKKVYNSTNPFDFMDMISLQGKTNFFEKRVSDYSKAGVSHSGENTTTQASRTFVLDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN29</accession>
    <name>A0AA38NN29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_167043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793911">
        <property type="protein sequence ID" value="KAJ3780110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32348" checksum="04A25608580C191E" modified="2024-01-24" version="1">MTSTTSPDNRNDLTKRVLQQMTLSSASNPLTAPFPKENLTPSERARQRFAIEGNAVVTGAGGIGLSVIRALLEHGASGIAIFDVPVSYATSIPAIDALKADFPQTKIITYDVDVRNENLVNDAVDRVVEDFGSISMLLCFAGVVGCEHAHEMKADDWKRVLDVNVTGSWFCAQAVGKKLIAQKSGGSILFTASISGHRVNFPQPQVAYNTSKAAVLQLTRSLAAEWSSYGIRVNSISPGYMDTILNEGDGLAASRAVWADRNPMGRMGDVEELSGAVILLCSKRAGRYLNGADIVVDGGGIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNH6</accession>
    <name>A0AA38NNH6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_391056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793655">
        <property type="protein sequence ID" value="KAJ3780785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNH6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="673" mass="74886" checksum="0E1ED87F65404123" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPF7</accession>
    <name>A0AA38NPF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_271005</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="EMBL" id="MU793368">
        <property type="protein sequence ID" value="KAJ3784655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="125"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="414"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="289"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="679"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="818"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="944"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1181"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1235"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1414"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="826"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="854"/>
            <end position="864"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="971"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1181"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1207"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1443"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3784655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1604" mass="178865" checksum="CE9AAFF002DB9051" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPT7</accession>
    <name>A0AA38NPT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_167655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPT7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="728" mass="81562" checksum="1C2B0A932E673887" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPU3</accession>
    <name>A0AA38NPU3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_350982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPU3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="89"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="545" mass="62657" checksum="40F096AB0178AFB1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPV7</accession>
    <name>A0AA38NPV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_350293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPV7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="122" mass="14754" checksum="4ABEC6E3723F3D13" modified="2024-01-24" version="1">MSAVPNSNSEELERQAEQKKLEEILDKIHYSDRYTDDFYEYRHVILPKQLFKYIPKEYWNKDTGTLRLLKDKEWRSLGITQSLGWEHYEVHAPEPHVLLFRRSKDYVPPPQPDPRAKEARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQW4</accession>
    <name>A0AA38NQW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_49013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="304" mass="33887" checksum="E7C9C254610D9502" modified="2024-01-24" version="1">MSSNGHGVNPGIARTMTGLLERTRTRRTFSKDSFTSPATNTSSPPSKSKVPKVDDLLAEQSRLQTELEKAVHDCKVAEKGKAEAERQSQDSLQLLVKERQALEDVKAEKEEAIREADVSKNALRAVKEQAEKADEESRAARERLEEELAEARRLAEETEKKLTQAESNLAKAEQARLTAITDAEAKRQALEQALKLTDRYRTAAEQMAKEKSESEEASRESLERAKQEAESSRAALGEVERRVNNEREARETAERELRRRNEEIPAPHTLFGYAMSTFKARETSSGSSRRGSSSSSWPTGCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRC6</accession>
    <name>A0AA38NRC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_283722</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3789706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="87" mass="10225" checksum="A07A120CB9EC21F8" modified="2024-01-24" version="1">MSGRQQRVLVQPINVIFKNLQQRTKVVIWLYDNVEMRIEGRIIGFDEFMNLVLEEAAEVFVKDTKPRRELGRILLKGDNITLIQQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRF9</accession>
    <name>A0AA38NRF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_283827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="588" mass="63575" checksum="30F6F2CAB875C5F6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS20</accession>
    <name>A0AA38NS20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_341621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="341" mass="38557" checksum="041555245B961885" modified="2024-01-24" version="1">MSPTSKIISRKLKKLLKTFLGGISTKHRQKIQSAIDGGGRLEPMFFRPEAYIPDHVWDSQNPGERYASVGDLCAHIGDQLPIYLVKQIARDVLRGLANMHQTRGKAHGDLSQDCILISPKDMKMLISQFYYPDVQSQHSMLHSSEISHTELHPIHLNVDTEVVSTAISFSPSSSEPLVFRVCYPEIDRPRHDLFCDSFGMRSPEALLGAPQDTSADMWTLGCILYELIAGESLFDPFFQTVELGLTPEESHLIQIIEVCGQFPKDVAKSGKNGCKWFYDDGSLRLETTYYPVTLKNILSSRIEQSEVEHTADLLNSMLKLRPLERVQAADLLNHPWFHDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSA8</accession>
    <name>A0AA38NSA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IgA peptidase M64-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_341201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSA8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041434741" evidence="2">
        <location>
            <begin position="24"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="557" mass="61502" checksum="C02E4878BC891AA7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSK8</accession>
    <name>A0AA38NSK8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_431096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSK8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="392" mass="44629" checksum="C111244FDEB63649" modified="2024-01-24" version="1">MPSDQSTWIISAPLNGDSEGLLQELTTKLSQQSKSLSPNSIAELGIPSFKTGTLDSLIALSEDLPKQDTFFTNTVAKVVDTLRNLLNNDPSKLSQHILVNESSIESYLLGQWRWNEGRYGVQKGLRDMAETLNKEMTSIDNAMRAKLTNYNLVKGSLVQMQRKKTGNLSVRSLADIVTKENFIQDSEYLETLLAAVPKNLVKNWNAKYERLANMVVPRSANVVASDDEYTLFSVVIFRRVHDEFIQQCRENKFIIRDFVYSEEEIAKQRQELDTADVTERELWTELLHLSRTNFSESFQILVHLKVIRLFVESVLRYGLPANYIGIVIQPDPKTVKKTFGILQSHFSFLSSGPRSKGAKSKGGDAEEFVGEYQSLMEQEFYDFVLYEVPWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSX7</accession>
    <name>A0AA38NSX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_282170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="70"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="196" mass="21743" checksum="B24DCCC8A5DCA4B2" modified="2024-01-24" version="1">MDNDYFSIDAILAENQKIQCKFKQRIPEMGHLGGGSERDILPLSKRQIPIWLAYIIVYSDWADFDIPQPFSNKVRNALRAEPRSVRLSNLVGAGAGWYVLGKTIMDMLGDEQGVEMSEMLITTFKGRLVDVIDQAQHFAVLGSVGGGGGGGVDSAPQMFREGLDTTERELFVLAQESARRMKKWYEEGSGGAKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT79</accession>
    <name>A0AA38NT79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_371084</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="99"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="537" mass="57970" checksum="5494B0851168DB8D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU75</accession>
    <name>A0AA38NU75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nonribosomal peptide synthetase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_301556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU75"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109656" checksum="52739864589BDAB7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TY25</accession>
    <name>A0AA38TY25_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_53938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TY25"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="496" mass="56732" checksum="4898BFD5F5CFF53F" modified="2024-01-24" version="1">MSLPNDVWLQIIEYMSPLAIQELYSVNSTFFNVAMDQRYQQISFSYLSRKMIWILARLKDPVVAKRVRILHLYPHFVKDALDTMDLSSSQSLLSKFGELAGLIRDQKKLILKQKPRLPLKFKTCRDLMQVMMEILSGLPNLTDYHVLWCGLPSVGSDPALVLSSPLRSSLRSLRLEVSLEKLQYILSSSYTQPLPQLEEIDLFIRIEHLHFERYDTILLMLARMISSLCSSLRKLTVQLWEPFDLSPLFAAISHLPLLDKLSLSIPMSFPNLGNPDGLIGFLNAHSNTLRSLSIRASELGGRSLMTHNEVQLGTWMDETFSKVHLSCLTALEISLYLVPFDSALLCVRSFSTTITSLVFTGSYLAYDDLDLLTAALSSRRHKHALQSARIGPLTLSPQLVDLFADRFSEIDKLELLVKSLVPFEGDVPLFCGRSNSDRDQDEGQVRRFIEEMEHRHYPEWKLRYLDLSSSSYPRLMNEEQYKSVFSQCVPALRTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U051</accession>
    <name>A0AA38U051_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_340599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U051"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="561" mass="62832" checksum="019E1B122E05D9DC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0D9</accession>
    <name>A0AA38U0D9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_339767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="462"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="881"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1307" mass="143336" checksum="5839D9F1F489E917" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1T5</accession>
    <name>A0AA38U1T5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_258341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1T5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38474" checksum="ABB3374197FD1415" modified="2024-01-24" version="1">MKKCDGTRPSCSQCLRRPGRPHVARCHYPNAKPSESQNLEADIRSKEALLQELEEPVLDDTTVKLSLPYAKAYDVEQLYQLSKRNAGKFEFLWLYYHIKENNRCTAPVLAEHDVFNNSLYHSMRITASLRSHHFLNSATEFGFFLHIHRFRQAASLPEGHSDKPHIGLLHVVKLWGHHLRQAQDKKAHYAGDDQAQNYLSLAMIHQPGIISSSHPKKVIHAVQAEVLLGMYLYHASRPLAAKYHLNAALNMALAAGIHKIRNLDASSLFQYPTATDTHEEGRRITEGEKINGFWVTLSLNICLEIALQSPLDELLMIQGQTLSAGVDMPWPMDIQSYATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U358</accession>
    <name>A0AA38U358_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_391551</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U358"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="219"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="476"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3791278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="547" mass="61223" checksum="0215A8830B135D2C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U5P8</accession>
    <name>A0AA38U5P8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_343261</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U5P8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="606"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="431"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3789585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="678" mass="75497" checksum="78465E88EBEECDC1" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U6J0</accession>
    <name>A0AA38U6J0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_3063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U6J0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="198" mass="23034" checksum="E967D4FFAE04611C" modified="2024-01-24" version="1">MSSNKTWVHSRLETVGLRYNMGRHVRVTRPDNWRDQSRPSTGLASHTANDGREYIVFNNAQILPCYVVHLDWPSNSEADYFVSNRLGRPEKRPRIDNSDSSPGDRQRLKENRLAQARKFFAYGFGPVPGTSIVIEDIADIEDDEEDYGDYQTSRLDDVQKVDIWTYRLAGETDKDEYTSQRKAHYRKSRTIRDEELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7A6</accession>
    <name>A0AA38K7A6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_382441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794798">
        <property type="protein sequence ID" value="KAJ3779484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7A6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041201858" evidence="2">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="17174" checksum="EB2C10B94692CCBF" modified="2024-01-24" version="1">MLFSAFLLHALTQPLLVVACKILAAIASAHSITTVPMNFLMTIQSFVSPMSGYFLAATVLTFIALRSISEPVSQLIWLPALIDLQITAFGFGPAPPALCHSRQNESTSHAGLLPATTFLIPPGTSSGQMKAESTGGNGTQISVSSNISYTFPQALDLFNIMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7K0</accession>
    <name>A0AA38K7K0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793910">
        <property type="protein sequence ID" value="KAJ3780114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7K0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="231" mass="25143" checksum="3CC6840F793F1DA0" modified="2024-01-24" version="1">MLFAYSGNDILLSEKDYVSLFVDGNLEDAPSTSESLNAHPKKRFQFTPVEGSSNPPPTAVGESDSVRIFRLVKINPDGNGHSEKLVYCQEYSEAISEPIITAGTGAAMQESYRQEDAVSLNNIFNSVSAQPSEGMSEQAQFDLTWMNFDTSIAPELGLDLTKMDLDTSFAPEVEMGWNTDFDANQQQQPQERTTPGSLSSFASVSPPALETTLDSMQTSIPSHGKSPLQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8T7</accession>
    <name>A0AA38K8T7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_407160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793455">
        <property type="protein sequence ID" value="KAJ3782769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8T7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041388772" evidence="11">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3782769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="492" mass="55875" checksum="9754C1462CC7C6B2" modified="2024-01-24" version="1">MWTQLLLAVGVLVAWHLLTRRRRHVMPPGPTGWPLIGNLLDLPTAYEWEVFAKWGEKWGDLLSITIFGTTVVVINSYKQCQEMLEKKSNVYSDRPYVPMAMELIEMRDSMGFLPYDKRFKSSRRLFHQELGSHSAVRTFFPQEEHLGKKFVRRVLRNPDGLLDHCFQHAGAIILRVAYGYEAEESNDPFVNIANTAMDNFNRATAPGAFLVNQMPILLKVPDWFPGTEWKRIGRAWAKDYWAMVDVPFNFVKKQLLEGTAEDSFTAKWLKQKLTPQEELDLKFASSSMFGAGAETTAVTVHVFFLLMAMYPEVQRRAQAELESVIGKDRLPSFEDRDQLPYVEAVCKEVMRYHAVVPNGLPHCTAADDVHNGMFIPKGAIIFANIWKMTHDPEVYKEPMEFNPGRFLGEAPEQDPKDMVFGFGRRICPGRLLGDASVFITLAMSLAAFDIAPCEGDTPLSLKNKSGIVSHLHPFKCKISPRMDIEILSALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8W7</accession>
    <name>A0AA38K8W7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_62955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793441">
        <property type="protein sequence ID" value="KAJ3783009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8W7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="332"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="43936" checksum="93747BB3C060CF3E" modified="2024-01-24" version="1">MANPEQEEQIEEQFITEDDVLAEVPDDGDQLMDEDEENEGEDIVGELVPGSSRSAEDNSLQAFTNHHSSVFSVAVHPTQPLAVSGGEDDLGYIWDITDGEVIVKLSGHTDSVVCVGWSFDGQIVSTGGMDGKIRLWRRVGQESYRTWEFLTELQGPDEVMFLKWHPKGNVLLAGSNDTTLWLWQLPSGNTMQVFAGHTGPVQCGAFTPDGKRIVSACGDGTLILWDPRSPSPVFKLTAEDARFDLDGITSLGINSSSTLAVVGGAAGGVRVVSLTKGEIVSALGGHTEGESIEAVEFIDLTGTVSGPGIVATGATDGKICLWDLSTMRLRSTLEHSDAVTTLLAVPAPNNHLLVSGSADKTLRTWDARTGALIKEHKGHQGPVLGASLGLDGSVIVSAGDDGVSLVFTTELEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9K6</accession>
    <name>A0AA38K9K6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_29520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9K6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041247878" evidence="2">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="194" mass="20933" checksum="77C9AE882682684F" modified="2024-01-24" version="1">MLAKTLFLIIISSLLSLSATSPLPATQDHTDYSRESGELNVTGSPSSSSGNVKRAPATKLVLNLIGCTMDVITWASYNPGRLTAKEDGILYGSVIPRGGLYFAVDPKDADVIGRASNCPGGRFVVAEYDFDGTGLRIVDMTAGQHYDETAHAVVGYFDPSRIGIRGKQMKMYVLQNPIAIVESHLKLKMINHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBH8</accession>
    <name>A0AA38KBH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetraspanin Pls1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_264102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBH8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="229" mass="25416" checksum="9081EFD90B198FA7" modified="2024-01-24" version="1">MVSRKLIGFWALFDVCLLAAGVVSIVFSVVYRKQDILLNLTISKADLTAALVMGIMLVATFVFSIGAIVQKNHVTMGLVILNYLLVADAVVVLVIGSFVWFFSLQQRNNFHKLYVELPASSRVFIQDKFSCCGYFNGSDAVEPSTFCTPSQIAFTNALDPSDVNNADSFCVTEVTAFTDYTLNQMFSYTYGFMPVILGLLLFTLCVINKRKEGERFKKIDAKRGGRGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBJ5</accession>
    <name>A0AA38KBJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793825">
        <property type="protein sequence ID" value="KAJ3780253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBJ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="271" mass="29842" checksum="7634AF4789B27E9D" modified="2024-01-24" version="1">MPDTESIEIDIPVANPNRPGSAPPIAFNIQNFPNVIVDWPAQKFSIRDSDTSVEYVVSVTELIQFVHTSGAIAKKWSINGGIPTKYIAVIGALWKHLPPNTNAYFSFMDEDDNVSRSKTLVRYEHIFTADQIEELTHNGHITNDLIADMSETFPKPTSVKGGKDSNDLDGVGGMMRMYANTRVGQTAFIHGLVIATEKAQFQMAKQQAAKEERAKKRTARSKPYKGKGKKNEADDASTTISLRHKMDMWAVRGNGGRDSDNRGEGSGINSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC12</accession>
    <name>A0AA38KC12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_256545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793628">
        <property type="protein sequence ID" value="KAJ3780928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="122" mass="13324" checksum="1BB2AB2542516EF1" modified="2024-01-24" version="1" fragment="single">LTSRIETLEKRLSASANAVKFPEKKCSNCQRVGHIAEDCFRKGGGKEGQFPAWWKGKKDTTVGPSSANATATSNDNGPDVAELTQFYGLAATSRDSAGDYIYADTGASDHFFRNREDFVMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD07</accession>
    <name>A0AA38KD07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_337499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793963">
        <property type="protein sequence ID" value="KAJ3780041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="239" mass="27070" checksum="683172AAB4228E28" modified="2024-01-24" version="1">MKNVTYEVGFIRSATRVSAEKGVWDPLNNSGRARFLKLKASIKSAKPPRTRMLPQGASKAVSKNVNPGPTGIKGPSKNSLIIDPLALWLPPDRLGFNSQNWEVLYEVVCSSIDAAQIGISGKDFFKAIKKARKELCKDFLGRVVTSCPCNKKSYCAACTVAMLKEDYKHEQFRCPCCRQDPAYFIAIDWIFINKPDEQKRCRALSKKQREITKKKRLREAKREAQELAEDELEEGELRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE30</accession>
    <name>A0AA38KE30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_293890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793369">
        <property type="protein sequence ID" value="KAJ3784633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE30"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="235"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="488"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="880"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="902"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="974" mass="108704" checksum="EE1384D130245D7C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFV1</accession>
    <name>A0AA38KFV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_433256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="119"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38845" checksum="FDB88DF5622B87C5" modified="2024-01-24" version="1">MTFGISIPSPMTRGSPSSDDSSQVHTPVSPTFAERPSNAAESSTGSATSSKRKSTRRANTAERRATHNAVERARRETLNGRFLDLAALLPNLSQVRRPSKSAIVNSSIAHIHASRRHRLLASRELRLLKHEADALRRELNEWRDRAGIPRAQEPSRGDAFSMILSGEIEVLPIPNEDEEDGEYGYGDEDGPGAVSSDDFTMDYPRRSSPNGNEVLIEQQMMRRVAGPMVASPGGMVVENPAMGMMYNNNLGNNTYSVPFATNLDQNKWGASTNVNEQRIMSSVPHRGSLATFDVRRNRDRAMSTGTVSSGGSGSPAHMAYYDPGWNATMGGMAPNMGANMGMMGGGPNSNMANGGATFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGE4</accession>
    <name>A0AA38KGE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_121704</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGE4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3788158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="126" mass="13827" checksum="022D725653E5D9A4" modified="2024-01-24" version="1">MSKVITIDDLKANNTKSSIWLLIDGKVYDCTKFIDEHPGGDEVILAESGKDATEAFEDVGHSDEARALLPEMLVGTFDKNSGMDLKKLSTAPTSAQKAIEHGSNLMYFIPLSLMGAYFAWRYYSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGU0</accession>
    <name>A0AA38KGU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_267157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGU0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="237"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="428"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="549"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="651"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="771" mass="85447" checksum="45B1ED000250BBC3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGV0</accession>
    <name>A0AA38KGV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_261962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="472" mass="51480" checksum="571A2ADBBD93F63E" modified="2024-01-24" version="1">MMLSSTVPEAASRLLSFVNTSPTPFHAVQTAVQRLEKVGFSKLKESDSWDKAVKPGGKYFFTRNQSTIVAFTTPGNWKQGAGLSIVATHIDSPNLRIRPVSKRTKAGYLQVGIETYGGGIWHSWLDRDLSVAGRVITSNNSGEFKSRLIKVERPILRIPSLAIHLDRGVNDSLKFNQETEFVPILGLISEQLNATSESSKSSTGELQASSIADNHHSALLNLLASELSVAPNEIYDFELRSCRQLYDTQPSQLGGIVNEFIFSPRMDNQFSSFCAVDAIIGSVSSNSLLEGNVNCIALFNHEEVGSVSSTGAESNLIPSLLSRLSPTPDLLAQSIASSFLVSCDMGHAIHPNYYNKHEENHQPRINGGIIIKTNAKQRYTSDAVGSFLVKKLVEKKGGKVQEYEARNDMPCGSTVGPSLSTMGLRVVDVGCPMLSMHSIRETAGTSDVQSCIDLFQSFFENFSQLDAKLIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGZ0</accession>
    <name>A0AA38KGZ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_351275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="144"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="11">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="385" mass="43546" checksum="1ADAAA446BBAF03C" modified="2024-01-24" version="1">MDALLKELSKLETLTAQSPGKNKTPSISDSLDDLVFTLQSAKADVNSIDEGSWNSLVQTIEARKKDIDDRQKEIYSATAKLGKAVEKKFPANLPSYPNLFESDHAIAALERTIALHFLRTGQFDTAHTFLEESNADISLELRSQFIELHRILKALRNQDIGPALLWARRHRAFLQSRGSPLEFYLHRSQYIRLLLTSHPPNPLLAISYAQAELRPFFHDHQAEFQRLLNCVIYLPLSRLRLSPYADMASPSLHLELEPLFAKEYCASLGMSRQVPLRVVADIGGGGALAKIEKCRRVLRERKNEWIQRDELPIEINLPPENRYHSIFTCPVSKEQSTEHNPPMMMLCGHVVAKDSLQKLAKSSGRVKCPYCPTESLSSAAIQVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL35</accession>
    <name>A0AA38KL35_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_300122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU793602">
        <property type="protein sequence ID" value="KAJ3781109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL35"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="597"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3781109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="803" mass="89244" checksum="E48638B16421C429" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM10</accession>
    <name>A0AA38KM10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunomodulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_363890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793477">
        <property type="protein sequence ID" value="KAJ3782414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM10"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041439346" description="Immunomodulatory protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13344" checksum="05FD9370BDB1BD49" modified="2024-01-24" version="1">MFKSIALFALLNAALVSSIALTPRAPAIAHNGLSSDAADAILVFTTCNRVNLQNCVTWTATTLPVGCTSLIPYGQGNAVQSATTPSGIACTLYNGQSCNGLSQLINGTVNDLSTVGFSRLANSYNCRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM87</accession>
    <name>A0AA38KM87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_370441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794928">
        <property type="protein sequence ID" value="KAJ3779436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="194" mass="22027" checksum="95EE5681B0BBC21D" modified="2024-01-24" version="1">MQVVNGLYQRFIHEASISQVADKFNEVTYNRKDGAKVMFSELKRWAVCMPIPPDLYTFKRRILLLVPPAMCKDMTRIEKVSEGIMQMHGLILNRRLRKLRKDTHGEIEIGPQSVSRLSINDDILSQIMNRSGRTTAPGRKAIPRMMAHHRGNLLGNEGRALTAENTTTTEGAHYANSRGLELNQINNNVRNCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMD7</accession>
    <name>A0AA38KMD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_298453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793499">
        <property type="protein sequence ID" value="KAJ3782100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="17292" checksum="71DADB8477E86DFE" modified="2024-01-24" version="1">MNIPVPPILALKAKSESFPFASKYIPLPSNISVILGSQTKDTNSGQTSTNRSATSTNGWFAPLIPVDGRAPVSPISLSPDHAQIWSSDSTIFIRDLGSVFGTYVNGTRITGEVALKDNDTLTLGLVVERNTNTPAYVADEQLLPVVANVTCVGVPSRPRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNF7</accession>
    <name>A0AA38KNF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793668">
        <property type="protein sequence ID" value="KAJ3780711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNF7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="755" mass="83981" checksum="74AB5D0E9B7A4A8A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRD1</accession>
    <name>A0AA38KRD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_374733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRD1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="122"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="263" mass="27408" checksum="95428F6B2C22ADC1" modified="2024-01-24" version="1">MTTRKAPSSNKGAKAAPPHPPYIDMIKECIADHREDARIGVSRPQIKKYIEEKYKIEIGAAQTTQISRAITTGSEKGFFVLPKGEHLSAALVLYPLLRRVKLAPKNKSPESSAPKEDKPVAKPRSTTAKKPATAASKNSTTKGTAASTKKAPAKAVPTKKPTAKTPASKTAAVKSTTKPSTKSSTTKKATKPVAAKKPTTKAATAKKPATKKASAIAKKAATGTTSTSKAKAAASKAKVSAAKAKTSTKAKTPAKTTAQKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRN9</accession>
    <name>A0AA38KRN9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_157321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="177" mass="19588" checksum="34C6CC68C393A2F4" modified="2024-01-24" version="1">MQNTASSASSSSSISSQSELSPSIVNNLHNASAPVEILKRPAAARKKRLEDDPWTADVSTVSVNCLGCGHLVRLSTKSLYDNHHWLMHKQRCKRAGNIKDNPDIGQSSPRQPAVVQTKSKSKPKLNRKAKVRGFMALFILRTCSLRGIVSLFVAAETSLRLFIRIISYAYQYSAFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRT5</accession>
    <name>A0AA38KRT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_386088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="360" mass="40356" checksum="8C814A5243D643BE" modified="2024-01-24" version="1">MDSSCRTSDSDISGIGVRSSFYLQSFLLVILVDRSTDASTSLWTFTAASFGLTIAAVIQYAKQQLTLLEALQVSNLVWLANFGIFVALASYSRHKRNTRRKHGGNKAKSGVTGGRRLERGHESDYGVKTASMVQTLLSMALTLYMWAVPETFEPSRCFNTLNYVLFVWRIPVRHSGRIVGLTFSAILTCVYVVITLHEYWISYRKRQRKAKKTRDPPPRALTSSSSVRHGPSPSFIIPSPYQNENLQTFSPSLSISQSLTPMKSNRPHRKLWSNIDPMFIGILFFESVVFLYLIVSNEILLRDNHADTGEFGFGQILALVVVLPVLLSVIGAFRENGFRPRSHTGSKKYRRAPKHSVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRV8</accession>
    <name>A0AA38KRV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_387872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793357">
        <property type="protein sequence ID" value="KAJ3784986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="143" mass="16727" checksum="E9C80BB0B488C534" modified="2024-01-24" version="1">MSLPIFQQICLACRYDTPGVPAAEPRAFSKWFSGTDDEVRKDKVDFYSETFYGKLPIRPYFIGFYKWLESLFFWLRAAYKARPELKDQSELFLPSQLQNSLRATSYDWDTLGGIFTYANMKQLMSSFQDQPLETRWSGEDSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTH8</accession>
    <name>A0AA38KTH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_309689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTH8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="45"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="482" mass="51687" checksum="009714711940E25A" modified="2024-01-24" version="1">MGSTKKQNKSYRTRATRSSGRSNLLTSDPLQNTVQLNNQLRSLGLYAAPTIGDGNCLFRALSDQYYGSPSRYGEVRREICDFIEAHPEQYEGFVDVDEFGDSSVRKGKGSGLSVYVAGMRQNATYGGHMELSAFAHLVKRNIKVVQPGLVYVIQWDPSQPKSPKSSSKKAGDSPARYTRSGSSRELDGDGDALITPGEDQDSTIYVAYHDWEHFSSVRNLRGPHTGIPRVYETVPPPTAAGVSPLSSLPPSPTEELDGLLDAATIPLPTSAPPSVATSPPTPICLPSNPSAVAIDPLSNLSHLTHLVPPPRIQRSPKRSFEESVGEEGSAESAISNSSVDSKRSRIGDVSSGATESRGRQGHRSQQAEDSPEPAETGALPSLKDDDPESADSDDGHHTGEEALQNGLPDACAYSERPLTRRQRKKLGLPKARNVSVSGKGIGKIIIPGGKAIKQSRDASSAAEWTANGNGRVDVRGFRELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTJ1</accession>
    <name>A0AA38KTJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_380421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793689">
        <property type="protein sequence ID" value="KAJ3780612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="207" mass="23041" checksum="24DCDFB0822F5F2A" modified="2024-01-24" version="1">MNPDPSADPDKVKKMRRRLRLSCIECTKRRQRCDRAQPACGLCKSRGVEHLCRWATVPFARPTPEKPPAITVAVAESEDKLKIQQLSDYIRMLEQELEQQYARTANTSSSADRLGFSRSPGLILNSSPDTPYRFCNSTTHAYGNGTGQNLLSSQNDLHPTILSSIACPQVAHPLKCQGSEGLFGRGSILYNILQLIDDPVGIYRTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTS6</accession>
    <name>A0AA38KTS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cu-oxidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_321024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793622">
        <property type="protein sequence ID" value="KAJ3780957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTS6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041257890" evidence="7">
        <location>
            <begin position="20"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="163"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="375"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="524" mass="57132" checksum="D342A29977FE756F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU17</accession>
    <name>A0AA38KU17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_320345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793562">
        <property type="protein sequence ID" value="KAJ3781407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU17"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="275" mass="29914" checksum="90F074CAFCEC32E9" modified="2024-01-24" version="1">MASNAHQYSEEQSAEDILNDALLFLGGRPVIDDEVISYGPLKLTVAPKAGKANTLLADHLFSPALFLAERIEQGVIPLQEKTLIELGAGCSLPSLASCIISSPTNIPSLVVTTDYPDPIILGNLRSNVERNQVLVPSTCKLHCRGYEWGQEVADLLNLLPRNQNASVGFDIVILSDLLHFQTSHDVLVRSLSLLLAKTVDARVYVAAGKYTLSDVCSSFLQKAANAGLIFKEDLHMNSEDGSKWQGTLPVSGLDPEALGIRKNNCRSWVGHWLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU90</accession>
    <name>A0AA38KU90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase subunit beta</fullName>
            <ecNumber evidence="17">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_286711</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="17"/>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU90"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="209"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3788211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="539" mass="57772" checksum="052BA6D39B9A5F6A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUF4</accession>
    <name>A0AA38KUF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="7">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_307037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="7"/>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUF4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000094">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="641" mass="69849" checksum="23FD6758036D12D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUF6</accession>
    <name>A0AA38KUF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_364803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793504">
        <property type="protein sequence ID" value="KAJ3782037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041329127" evidence="2">
        <location>
            <begin position="33"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="154" mass="16814" checksum="FD16495C6C725263" modified="2024-01-24" version="1">MRCDCHYYSIVRTLLFLSVVSFLGQPPLGISASPVQKATSMNLASIPSTTATTCPFKDATLPNHSGSTNSSSKQASVKTKDQHEKRARSLKLYRLECFEKLVDAVQDPAKTVIPGPTSFSYLGGLDMTPDPETAEAWGLYELQLREILDLSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUQ3</accession>
    <name>A0AA38KUQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_275446</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793473">
        <property type="protein sequence ID" value="KAJ3782487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="430" mass="48446" checksum="5AB219B21C512050" modified="2024-01-24" version="1">MVATPCAVPRLSSGLRLEIAGVVIAIIVAYLYLHRRRVHHLHHVRRLPNPPGPKPAPIIGNLFDIPREKESAAYNKMANDYGDLTYLNVLGKSILVVNNYTTVQELFDKRSANYSDRYQAPMTELMGWSWNFGLMSYGILCISHQHSQQSVGSRWKMHRAMFHRQFQSSTVSVFWPTQLKEAHKLLRRILHNPKDLANHLRFNSAGIIMNVAYGIEIEDKDDHYITVAETALDGMAKAANPGAFLVDIFPILKYVPSWIPGADFQRKAAFWRKSVLEMRDAPFETVTKARKFGISTSSFASNLLADLELRRDLDEVALSEELETIRNCAGLAYAAGTESIASSLSSFMLAMMLYPEVQEKARQELDAVVGLERLPDFSDRGTLPYIDAVVKEVFRWNPVAPLGLPHMTTKDDEFKGYHIPAGTLVLGNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW13</accession>
    <name>A0AA38KW13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_395380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW13"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="256"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="545" mass="60579" checksum="7EC2C38A982E4F4F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW65</accession>
    <name>A0AA38KW65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_251959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794083">
        <property type="protein sequence ID" value="KAJ3779903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW65"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3779903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="115" mass="12988" checksum="7A998890543FA9AB" modified="2024-01-24" version="1" fragment="single">SQAHLASKFDELEKKISAQLLRKGQKSDKECTNCARKGHVKEECYRKGGGKEGQYPSWWRGRKESTVPTNANLAVTDFSQPYALMANTTKVMGSIYADSAATDHFFRDRSDFITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWS1</accession>
    <name>A0AA38KWS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_351781</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="10"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3786432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="173" mass="19236" checksum="6616FADEB3F46AB1" modified="2024-01-24" version="1">MASRGASNATALRRLMTEYKQLTSGGSPDGMFTAGPISESDFFTWEALICGPKDTPFEGGVFSAKLTFPSDYPLSPFKMKFEPPLFHPNIYPDGNVCISILHTPGDDPTMYEQASERWSPVQSVEKVILSVISMLAEPNLESGANIDCCKLYRDNQQEYERLVRESIKEQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXC3</accession>
    <name>A0AA38KXC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_144059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXC3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="205"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="287" mass="32279" checksum="15A2303D43016DD0" modified="2024-01-24" version="1">MSRPELQAPPEIYYGDTEAKKYTKNTRNQQIQADMTYRALELLNLTPDEPAFLLDIGCGSGLSGEILDEEGYIWAGVDIAPSMLEVALEREVEGDLFLQDIGQGFGFRPGSFDGAISVSVLQWLLNAETSHPTSSPPHRLNRFFTTLHSALRNPSRAVFQFYPSSDDQIQLITSIAQKAGFGGGVVIDYPNSNKARKVFLCLYVGGGGGQQHQIPQALDGDVIEDGKVRFEKRRARDLRKDKNGKRKSQKVVDRDWILRKKELYRKRGKESVPRDSKFTGRKRKPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXG9</accession>
    <name>A0AA38KXG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXG9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1126" mass="121424" checksum="7A617FAFB7B2B600" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXV8</accession>
    <name>A0AA38KXV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_407786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793465">
        <property type="protein sequence ID" value="KAJ3782603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="2">
        <location>
            <begin position="267"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="548" mass="59806" checksum="167C4996E2D5E462" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY31</accession>
    <name>A0AA38KY31_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_245636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY31"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="238" mass="26194" checksum="801085DA3DCFDB9A" modified="2024-01-24" version="1" fragment="single">MSVLMMPNVFVIPPEEDNDPPFCCFDAKFPRERYIPTEEDLEAPGSALEIISQQLSNNSPVFRRGSYANGVVMPRRGDGRSIEEVLAGEDEYRNPDITIRSANPPGDDSEIVEVIKVRRHTQDERQNQQAEPAVKSSKSLKSRASRAFSSIKSVGRSMSRSRIIAEDVSSDAESSRAPSPAPSAPSRRGSMMFSSLFKHSPSLKSRSSFDSFNEATTSPVLETSPSVPFDIQLHSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY46</accession>
    <name>A0AA38KY46_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_98341</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY46"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="79"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3788607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="469" mass="50366" checksum="90D1F1E89A11F11A" modified="2024-01-24" version="1">MKASTSTTPSSIPVAHKAPLPPSSSRSSRIAPHSHIKGLGLNAEGRAITDTAAGGFVGQENAREACGIIVDLVKSRRFSGRALLLVGAPGTGKTALACAVSHELGSKVPFCPMVGSEVYSTEVKKTEVLAESFRRAIGLRIKETKEVYEGEVTEMTPSESENPLSGYGKTISHVIVGLKSVKGTKQLRLDPSIYEAMLKEKIVVGDVIYIEHSGAVKRVGRSDAYASSYDLESETYVPLPKGDVHKRKELVQDVTLGDLDAANARPQGGQDIMSVMGSLVKTGRTEVTEKLRKEVNKVVKGYVDQGVAEIVPGVVFIDEVHMLDIECFTYLNALLESPMAPTVIFATNRGNALVRGTQDLVSPHGIPVDLLDRCMIVKTEPYTKEQVAKVLQLRANIEGLKLAEGVLDKLATEGERSSLRYALQLLAPASIIASINDRAEISLEDVGEMNELFLDAKTSAAMISASENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZF2</accession>
    <name>A0AA38KZF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_354874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZF2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="8">
        <location>
            <begin position="48"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="431" mass="48966" checksum="7ECBBE839C419F72" modified="2024-01-24" version="1">MSRLSTRLITSRTQLHNPFGYPKRQESTALHFYQNKQLEIYASKEPKPLTLRQLIFFGRSMDEERLVKSANYVRTELPVRIAHRLRDLQKLPYIVVTQEGIAKVYELYWSAFEKFRKYPPITNIKENDAFCEFLAGLLDEHATVIPNLSLGMSLSSLYLAPDDLDSFMRRMLVSRISRRVLAQHHIALSEIYAGKHKPWDSSEPNVGIITTGLNLKSSIEKCANLLRHQSLEIEDFDGNSEIPAEVQIEGDAEMRFSYIREHLEYIVFELLKNSIRATRSKHAGSTKLPPIIATIAAGDNAIGMRITDQGGGLLTLQNSVQNPADLFSFSHIRNSARMEHSRLLSLRTASSYHRGIWATVNEQVENWKRLPDPEKEDGVERHARMGIGLPMSNIFATYFGGSLELKSLDGYGTDAYVRLPKLGTNLEAVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZS4</accession>
    <name>A0AA38KZS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_255548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="129" mass="14545" checksum="0C280083DFCC9C31" modified="2024-01-24" version="1" fragment="single">FGDPLAERLEYSLTQSAPFFGELPSDEAVGSIERFVAYRISDHTHLLLDSAYEDSECQISTSLLTNPDFDPSEWYARKLNVESSPTARNETSSRRMGDARGTRVSQILNGAARYPGDNLPDFHPRRNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZZ7</accession>
    <name>A0AA38KZZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pali-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_374553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZZ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="230" mass="24396" checksum="6DC1FEE773CBA2E2" modified="2024-01-24" version="1">MFATIIISCLLFIAFLLLLLVTLSVPIIKTIYLFTLTASVSSSLESASSSVKFGVWGYCISGVDISGIFSDSVIAPECSKAHLGYTIDSTVASALNLDSNKLVHVVSETTTAALVLHPIACGLTFLTLLVSLFMLRRGSNGSVRLPSLITLGVGILATLLTTIIFLIDVIVVAVVRNGVKDNTNGVVTLNWGNAVWMALGATLALWLAMVGTCGGVCACRTRHRRNTEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L001</accession>
    <name>A0AA38L001_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_350484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L001"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="145"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="830" mass="88418" checksum="878F7C529FCC1DBA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0H1</accession>
    <name>A0AA38L0H1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bestrophin, RFP-TM, chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_346921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0H1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="559" mass="62537" checksum="6848033ED85614BA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1V6</accession>
    <name>A0AA38L1V6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_415133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793682">
        <property type="protein sequence ID" value="KAJ3780637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1V6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="157" mass="18173" checksum="DEEEB5964299E4C9" modified="2024-01-24" version="1">MSLFTDSDVCNTPAVPTTARICTGSGRCQTKLPTDYKWKSCDKCRLSARARKQKRSANKRPRDDDDDECPAPDHAPLNPAQRLYDSEGETRSALYVRYLSAEAMFKDLQKKIKEDHVEFGGEYTIPFDPLISDRERVQFTIREVWKTTGYRFTYVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1W5</accession>
    <name>A0AA38L1W5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydantoinase B/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_136572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793671">
        <property type="protein sequence ID" value="KAJ3780697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1W5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="589" mass="63551" checksum="9EDA83F97EADCF2B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L338</accession>
    <name>A0AA38L338_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_67726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793443">
        <property type="protein sequence ID" value="KAJ3782977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L338"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041401905" evidence="6">
        <location>
            <begin position="26"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="62"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="574" mass="60711" checksum="11D0C9642E20E518" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3L4</accession>
    <name>A0AA38L3L4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_316157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793404">
        <property type="protein sequence ID" value="KAJ3783787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3L4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="198" mass="21284" checksum="E28427718C6BABE7" modified="2024-01-24" version="1">MAPSQQQPYVRSGEHLNEFLPAFWQRQINAAELETSDYRHPILPLARIKKVMKSDPDVKMIAADAPILFCKACEIFIEEITARAFIIADSNKRRTLSRSDIAAALSKSDQFDFLIDIVPRDLQRGGAASVSAGGPRKNAGASGTTAGTDGGAGGSRTQDGQSYRDSDTSVTGKSEIVDQLDSLLNAHSSTPDSSTPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3P8</accession>
    <name>A0AA38L3P8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_364736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793502">
        <property type="protein sequence ID" value="KAJ3782065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3P8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32092" checksum="9398214E5DB8DB0A" modified="2024-01-24" version="1">MPSPPIQVFLTTIASQPALRQRQGDCAYLARERTNQSTEYLLRILQVKKIPFTSYDLASDEISKRLWKRKAPLDKQQLPGILVGGKFPGTFSDFEEAVEYGELDQFLRLKETWNDEVDNITKPPVQPIGVPGAMLPLQMTPEHLRTKILVSPQSTPGKKPVPVNRPGVRDGEFDVSTELSGYGLQGVMATEAELADLVAELGLDGDEAGDLVKGLAGSSSAMEQQEQGKQEVKAEESKESTKKESRRTDELKVSNEDSEEWKKTPKEKETSELEKNSTEEDLTISSKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4A0</accession>
    <name>A0AA38L4A0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_60808</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4A0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="323"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="573"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="675"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3783130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111468" checksum="0F9610B1EC170480" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L503</accession>
    <name>A0AA38L503_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_172841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L503"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="553" mass="60359" checksum="50DB66EE275547A3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5H3</accession>
    <name>A0AA38L5H3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_313094</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5H3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="277"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="989"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="777"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1005"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1046"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3785335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1232" mass="135000" checksum="757AF32566254FBA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5H5</accession>
    <name>A0AA38L5H5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_433147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5H5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041362136" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="446" mass="47231" checksum="60EB4A8DBAEFBCC4" modified="2024-01-24" version="1">MDRLYRILTFVPIISLAAAQSVPEYGQCGGIGYTGSTACAAGNTCVILNAYFSQCLPGSTSVATSTSATSSGSTTTTTSTSPTATVSGFVKTSGTHFTLNDKPFTVVGANAYWVGLMNYDIADMNTAFADIASTGATAVRTLGFNEVTTPDGVAYYQSWNGSTPTINFGANGLENFDNVVAAAKAHGLRLIITLTNNWSDYGGMDVYVNQLLGQGSPHDYFYTNATVIAAYKNYVKTFVDRYSNEPGILAWELANEPRCLGSTSASSGTCTVSTISTWAAEISAFIKSIDTNHLVAIGDEGFFNDPGNPIYVYQGSLGIDFNANLNISTLDFGTFHLYPESWGEADSPGSFGSQWIEDHATAMIASNKPVIMEEFGVTIANQNDTYSGWYSTVLSTGLTGDLIWQAGSDLTNGPTPNDGYAVYPGTDVYVLDTQHAAALKARDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5X1</accession>
    <name>A0AA38L5X1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_178153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5X1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="5">
        <location>
            <begin position="175"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49980" checksum="A54A941A23983BAA" modified="2024-01-24" version="1">MSAITFARQAFNREKPHSSITNWVDILTANHIEEEAYDGIPELVDSINLQGLTGTGEASRALRKKLKHGGPHQQYRSLVILKALVENCGDKFKTSFADDQLIDALRQIAGDRTADKRVQKKLKLVLISWHEQFKSNPSMRSVSELYHMCRDIQPAKPAIDPMEVEAARRRAEKEEMKRKARLEKEEARKKEEAERLKQKQMKNRPKRTPFNFEQEKPQVLASIVEASQASSNLVNAITLVNPEKESIQSNERVQDCLAKTKVARKQIVRYIQLVENEEVIGVLIETNDRIIAALEMYDSMSSPDSKPDPISAATAGVDATHISPESEVSKLQEKQKAAVQKAKLNGSIRNGSTGGVYADLEDLNFGTLGVSSSNLPPPLRPTNMSEESTEAATRGSLSDFSDYESSDEETQARASSSTYAAKDYVSDEGATRGLKTKASIDDPFADPFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L602</accession>
    <name>A0AA38L602_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_332431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L602"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="79"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="407" mass="45272" checksum="AB5785CD861DFA89" modified="2024-01-24" version="1">MGQSKRWALKAQAVMWRNLMDIGMHLHMLAPPPAPAPSFSTTILSKLASKSGKIPLHFYVPESYNSDETKQSKRIYPVVINFHGGGFTIGRATDDARWARAVVHYADAVVVSVDYRLAPEHPFPTAIEDGVDATLYLVEHADELKIDPHRIAYSGFSAGGNMSFSVPIRLAEEYRTRKMQREAGGSAIASSSSDAASATSYTTTQEGTVIAISSWYPSIDYTNTRDERRKTNVRTDKELPKFFTNLFDASYLYPVNGVDLKSPWLSPGIAPSEMIKDLPENIVLYTCEWDELCAEADRFHHRLVNDFGKKVVYKKVIGVAHAFDKTPNPLHWDPKIETMYRDACRELRTVFYGSSTDSAIEEAVAEGKEGQQASVTTRIEDIKFPSSQDSLATVGSQYQQPVAGNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L669</accession>
    <name>A0AA38L669_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_165342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L669"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041232531" evidence="1">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="17796" checksum="BAE54EB7DAE64BC4" modified="2024-01-24" version="1">MLLIPTRVVAIAFALFTMVASIPVSPTDPLEINPDKPSLVQIRSQGKSKAPPNSLIVWITFAQGISGTSSTPMQNRAEGVVKGGMAESTDNYALRRNRVLRFRNAYTGNLRAGQPIQFKAEDEWLEGYCHPYCLGSVAFRGVGQFYGRLEHEASQYPALPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6T2</accession>
    <name>A0AA38L6T2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_346783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1398"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1572"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1641"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1690"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="2039"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2574" mass="281592" checksum="4EBE6E5CC0305CC8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB03</accession>
    <name>A0AA38NB03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794193">
        <property type="protein sequence ID" value="KAJ3779806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="18282" checksum="807AA2A035868106" modified="2024-01-24" version="1">MYNRVFTESSLFVCDGTDPTSDLFCQDATMGIIFVAIVTVFLLGVVVIIMALIEGVCFIAAQAYTYLAKYNPCDKENVLKRREQAVVLRELAVNRQERTLQMDVEIKVCERLTQILRRSSASVQERAYELEIEKDLLSEIAGCGGDTSGGGSLIHRIPKSPIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBF1</accession>
    <name>A0AA38NBF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_132917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793645">
        <property type="protein sequence ID" value="KAJ3780841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBF1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="182" mass="19845" checksum="BE91E4981CD06726" modified="2024-01-24" version="1">MNELKKLPNLPPNDKFVSIMQPFILQANPSVEALKTMAVTVDTGLRSLLAYFGENPDSPEAPKSEDFFGLILSFSSSLQKCSLEVHEYQRKLELTLPQPEITVALEKEASEPTIKLQSPAALLAPGSQSSMGKSVGRGDLDQAIRSMRDGKRRARPAATRTLSKIFLDGAPAGGRPTSRMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDC7</accession>
    <name>A0AA38NDC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_394392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="383"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="801"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="881"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="849"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="985" mass="105389" checksum="0AA21046A948BE07" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHI0</accession>
    <name>A0AA38NHI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_278906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793668">
        <property type="protein sequence ID" value="KAJ3780707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHI0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="122921" checksum="09A67E43D0EE53D1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHI8</accession>
    <name>A0AA38NHI8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_368548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793653">
        <property type="protein sequence ID" value="KAJ3780797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHI8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3780797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="540" mass="61328" checksum="53A246FE9FE0F7D3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHM6</accession>
    <name>A0AA38NHM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_367328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793581">
        <property type="protein sequence ID" value="KAJ3781262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHM6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="333" mass="35047" checksum="BE88D1255278D199" modified="2024-01-24" version="1">MTTEQSKTASPAASEHPFPPTANSASASVPPTFSHFTGAYPPTLPPGYPPFFAFPPPITDGQQGEGNSAPLPYPLLYPPGMVYTFPPQPVPSATPAASSAFNSRPKRRQVKMACTNCAAACKRCDEARPCERCKKYGFADTCVDGQRKERKKGIKRGPYKRKNKSSEDNYEYSTQPSDGGEWSQGSPPPPSTAATSTTIHPVAQLPPVPEGLYPIYLPPGYALPEPQPNGDGSTPSGPTLVPFYIGGFAPYGYPPGAVFQLPPPGTHPPPPPSSETTTVEAGAVPAAAKDSTEVVLDPSVAPVPTPTPPSEANKDQTKGSDDIMDRRPSTSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHY6</accession>
    <name>A0AA38NHY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_335664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793485">
        <property type="protein sequence ID" value="KAJ3782312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="226" mass="25286" checksum="845CA36059AC19CC" modified="2024-01-24" version="1">MPVDMFQSYENDDAGFEFNSLANQTIKATQDIRDHGGQLEANNTQELASISTLGTSNNQKNCQTIHTQSEHLNTANDTEKQIDSDVRVRHSQSLHFSNSLFWPILVNKDNSSLDDEQKIQIRWNVSYYADTIFALMFGLGALVYTAVAAKLAWNIITLCQQNLRIHNWVLGTLISGASALAFCLIYGMPLDYVQEFPTLFVWVTVLIGASIIVFIVGELSISIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI39</accession>
    <name>A0AA38NI39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_274763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793450">
        <property type="protein sequence ID" value="KAJ3782837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI39"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7016" checksum="C7320B1F17EB0B22" modified="2024-01-24" version="1" fragment="single">KVNVWGCITPWGVGELLRINGSLNAEQLVELYHKGLLCTLNMYAVPHHCILFQQDNDPKHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJT6</accession>
    <name>A0AA38NJT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_277573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793560">
        <property type="protein sequence ID" value="KAJ3781429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJT6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="170" mass="19393" checksum="F2A7138907373C53" modified="2024-01-24" version="1" fragment="single">NAHDADIIIRSSDNVDFYVHKKNLEFSTGGFPPANLTSSNSNEVVALSESAATLEIMFQFVYPKRYPALHKLNFEALMLLAEAAEKYEVFALINSCEFCLRNFLNQHPLTILDFAARHVHDYRSIVEELAMILVDTPMTDLTDLPSTIFKPWVCWTTECYMSFSNPINFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK56</accession>
    <name>A0AA38NK56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_389773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793468">
        <property type="protein sequence ID" value="KAJ3782568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK56"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041296148" evidence="2">
        <location>
            <begin position="26"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="241" mass="27012" checksum="3B7C46A222133135" modified="2024-01-24" version="1">MMYPRSSPFFFLMFFGLYEFHIISARLYPTRPVSGTVYHCGKCDPITWMDDGKNPSMQNLGLLTVDLYCKDQYVFTIEQADPDAEMLMFCPPSPHDFQWPQGCNAYTLLFNGDNPSENQTIYTHDFRISGTSRAAKVEFMNHTIAGNPALRTALGVGSQTLTISPTTSVSQVPTSTTPASLTDERHRSDTSATTIYADPLTSTDRSHRNGASFTRSIDMEKLKFRFVFIVWPALIGISMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM29</accession>
    <name>A0AA38NM29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_187132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="993" mass="110330" checksum="196A531F63DE75AE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMB3</accession>
    <name>A0AA38NMB3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_173579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="205"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="354" mass="39763" checksum="D1356D0CA5F7BF46" modified="2024-01-24" version="1">MFCYRSLYHLRPQTRKLFGASGTIRFRLQPVRMPATLQSPGEHQPLDNTMGAILVGILVSAVLYGISLVQTFFYYNHYRNDAWYLKSLVAATVFFDTMHLCFITHTIYFYLVSRYYDNEQLNNMIWSVLAEAIPTGFTGTLVQTFYTIRVWRLSKKNHVLAVVIMSIVLAQTACGTAWVIISLQLSTFQQLLDISGLTVSINALSSAADVIIAASLCFLLTQSRTGFKHSDTLINKLILFSVNTGLATSICAVASLVSLIASPDSLLYAPFYFCIGRLYSNSLLATLNARKQIRNNSNDNEHMMVSLSQASREQTALPTIPKVQRPQNIAIRIDTAKEYVSDRKMDENSDITFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMG0</accession>
    <name>A0AA38NMG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_351725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMG0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="628" mass="73078" checksum="2BE6719877D44B0E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMY6</accession>
    <name>A0AA38NMY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_416035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="393" mass="43800" checksum="52B58AB5B21AA163" modified="2024-01-24" version="1">MSAESTRSSHFDFWEFVSCAKCQLPFNANGSTVPFWLTECGHVVCNNHLSALSEYQGYMHIEQLVPLQHDMEPPMSEWFRSVPYILDSAAYAVKFQQESMASQIRNLKARHQQQRVYIDRLKKENAQLKQSNEMLTMQVIGMYDTPHEHDEPATFPNSNGKRQMIEVSHPPSSSSPRSIVTPVGPNRITLPPGQQPPQLSSNQAISPDIAARHSQRPGTNRYTQQFAYTPIQEDQACHAQLSHTQAAPKQLRRALQADNQISNASRSQIHPVPAAKHEFLPYSNSKSLQASHSNMGPPRYPQNVSTNVQPSSTHSIDQLPNPTRFLPLTERFPPPPGTAITAATSRRFVPPASARSNLRPSTSSLLNNASNSLSRGQPNVSRSGQRMPFVPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNI7</accession>
    <name>A0AA38NNI7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_306287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNI7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="6"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="916"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="405"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1026" mass="111929" checksum="7955EE741F981B33" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP74</accession>
    <name>A0AA38NP74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_389125</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP74"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3783410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="581" mass="66131" checksum="192DDE1F46919BC4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP99</accession>
    <name>A0AA38NP99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_388823</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="MU793404">
        <property type="protein sequence ID" value="KAJ3783785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 22" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="36"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="463"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="692"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="885"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3783785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1358" mass="147488" checksum="96BEE3D9F9D34DF4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPB2</accession>
    <name>A0AA38NPB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_402993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793395">
        <property type="protein sequence ID" value="KAJ3783980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="648"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122528" checksum="1BCBF5B7D32D546C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPD7</accession>
    <name>A0AA38NPD7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793379">
        <property type="protein sequence ID" value="KAJ3784355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="555" mass="62346" checksum="6008F7B3D60B9754" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPG7</accession>
    <name>A0AA38NPG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_400322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29235" checksum="1D2BA5449147C65B" modified="2024-01-24" version="1" fragment="single">MKDGLKRQRFSCLELLPVELLHEIQLYALSHHLPCTSRSLHRIFKFAPPSFKAEYIYLRLCDTTDGFYSKALRYPLCSLEVLRFIKQYTKKTEINIIVIKTPKRLFQGLAPRKYGSMWTDQDHPLPFIRGLYSEGFSLDIHSMNDYPLIKAVHTGFEALVQFLLEKGASPAYKDNLAVRVAIRRKDLRLVKLLVERSESGEKKTKKRKLEDRVTITKDLLKLAVKCNTQEIVDYFTQEKGCVPDMQTLYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPN2</accession>
    <name>A0AA38NPN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_353884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPN2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="308"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115618" checksum="A8C020750223DE98" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ98</accession>
    <name>A0AA38NQ98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_344547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ98"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="158" mass="18112" checksum="6BCA9EEA9D9107C0" modified="2024-01-24" version="1">MDIRLARAEDFVGMQQANLVNLPENYHIRLWIYHIVTWPQLSYVVEDSKGRIIGYVLAKIEEESEDKTADIHGHINSISVLRGYRRLGLAKKLMLLSQEAMASVYKAQYVSLHVRETNKAAIGLYRDTLGFEVADVEKGYYADGEDAYMMRLNLESEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQA9</accession>
    <name>A0AA38NQA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_71077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQA9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="287" mass="32576" checksum="C70F6BF4B0532F11" modified="2024-01-24" version="1">MASVAFAPLTPLKYALKFALIPFLCDVWTQICDRFKIKSTGIRWRLSSFIELRRAFFAHLWRVFGRGSDQHIHNQKQALLSPAQGVVLDLGAGLGGIASYLSRDKVFRYIAVEPNIHMHSELRDAAHEAGFHESDGTFVLLSCGAEDVRAISECASTVNTPTNTQGSVDSIICILTLCSIPNAERIVTQLVKDVLRPGGTLFMFEHVRHPIINVAWWQWLWSPLWSVFFDGCRLDCVTDQWAEEMRDIEESGRNIAMWKERELKSDKGDGWENNIIYHVIGTFVKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQE4</accession>
    <name>A0AA38NQE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mur ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_407001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQE4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="473" mass="51591" checksum="86669F51EF3B6B44" modified="2024-01-24" version="1">MSIDLSLDRIQRLYRFIQPYARPTIHIAGTNGKGSVSALTSSILAAAGLRVGRFNSPHLVSIYDCIYVNNQEVSQQTYHSSRDEVERIARDKLIEVSSFEMLVLTALLIFERADVEIVVMEVGMGGRLDATNVIPDEVVMLSALTAVDLDHQAFLGNTVAEITKEKASIARRGKPFVLGPQKHPEVAEVARKVVREVGGDFFSAFAALQVPLNDRIHPELPGLQFQPPSPRPIELDLPCFGTRVNALLPLHGSHQLDNVGLSALIISMAVDHPSCSSLRFRDRVTTEAIARGIANVSWPGRLSFHSIHSNLRDPTSPRFLVLADGAHNPASSTTLSSYITEYCNSLAPSNATITLTYILSLSHSPPKTPLQTLSPLLPPSLSPQLTVKVRVAVLRFTPPDGMPWVKSVPPSVLHSVVRSLCPKAELWAGDDDKTHDLPAALKWAATSPDPQLVVVAGSLYLAADFYRILRAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQE5</accession>
    <name>A0AA38NQE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_406939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="871"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="961"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1266"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="962"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1159"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1301"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1389" mass="157863" checksum="3C76AE6C9E02E068" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQN8</accession>
    <name>A0AA38NQN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_305133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQN8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="32"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="335" mass="35562" checksum="7FF20A692A559916" modified="2024-01-24" version="1">MGQGELVQIGSITISPALINTACAWASSFDQLQALYLTSLTGAVTTRTSTLKGYNESSSCGVVFTSSSTSSLNSYGYSPLPLSVYLGWVKEILSDAIASSSRKPLKPLIISITACSAEELVPMISLVQELRSTPMFSSLIAIELNTSCPNVSHASPSGYAPSSIRPLLKTLYEAHMRDKSLVIGLKLPPYTHRGQFDDMISLLMEFNYNDANKGRCNSFAFLTCTNTLGNSLLFPDQVTEALRTPESKVTTEFAVPTAVGGLAGDAIHAISLGNVYTFHQLLLENDGLRGISIIGVGGVTSPAALTRMHKAGASVVGIATLLGKEGIRAFELLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR30</accession>
    <name>A0AA38NR30_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_329913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR30"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="646" mass="68941" checksum="A2E8BD029BF836E5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR32</accession>
    <name>A0AA38NR32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR32"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041273019" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="73" mass="8189" checksum="8A17F35282B60EE5" modified="2024-01-24" version="1">MRFASAYLGLIGLLSLARAMPMNQQPGSVDRTTFQYIYVVEFLENPPPPMENPPSTEFGLVKLISRMSIPFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRL7</accession>
    <name>A0AA38NRL7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_342031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRL7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="666" mass="71256" checksum="B830036AF33841B7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRM4</accession>
    <name>A0AA38NRM4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_342483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRM4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041294688" evidence="2">
        <location>
            <begin position="27"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="338" mass="33257" checksum="3DD19D5ADD41E8B5" modified="2024-01-24" version="1">MIKSNGLVRLALSILLVMTLLTACNSMPIGMSKLSGSDEDSALSTSSAEGGAPISSTSAINPTDPTATDGASPTTTTDSSSESTGSFSSTAADLSSPTSSASTSGDSSSATASANISSASSSPVAFSSLSADVSSATASASVSSGAGTSFASASASSSSDTDSVSTTASSSSGSDTPSILGTSSGSASASASSFSSADTSSNSSSSTTGDVSSDSSSSSSASSSSSGFSSSASPAEQNHDGVPNLMHPLAKVGQSENKTISDHQRWPSAVAAATIDGAIFPETSKHPRVRAGRLSFKIGQKCKEMKEKGYWSNVGEGLKKSITILPLIFEAMVKTARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSC4</accession>
    <name>A0AA38NSC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_420536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSC4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000534">
        <property type="entry name" value="Xyloglucanase Xgh74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041454778" description="CBM1 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="798"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="743"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="751"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="836" mass="87721" checksum="33755EC59C05D546" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSE1</accession>
    <name>A0AA38NSE1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_329451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSE1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="446" mass="49524" checksum="90B2255C68C69E91" modified="2024-01-24" version="1" fragment="single">MQQRLDVRLQIQFTAKKKGEAFKLSELKDAISFFLSDSTPIPTSANFSTGDPSVVPVLVKPELTDNTISELAKQVASLSSMFAQFKKESESSSAVTSQQAAGPTAKQKKACRWDGCESRKFSDCENLKDWLAKGRIIREASSGLVRLKGGASLPDDERYSKGLIKERFECYFNDHPSEKSWTLEIAPESPPLFSTSLPGNLAGIEVSRHTPYSIHAYQGPAMLAKSAAYLTDSTVTDEERNELKEVLMKMETRRAAKVRFERDPPPHTSQQPDPEPAQPIPNSPPAVKPPKPIIGKLPETYVPPTERTVGAPPKDDRNYRFRAPIESEAAIQRAIEAGMSTIVPIRQDDLLAIAPDYRKKVRDSVMARRIALDGALTEDINLSYMFNHNGYLNNLNKPRTYKNSASVDPFQVFFNDMGDAEEGDGFYVARDSHSIRGINAIIGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSJ4</accession>
    <name>A0AA38NSJ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_282600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSJ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF1">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041277889" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="191" mass="20117" checksum="D02D071319B08FB5" modified="2024-01-24" version="1">MRLFTAFTLTALFAVVSAHFQLQFPPPRGAFVEDQEPNFCDGYDSVASNRTSFPLSNGIISLNSEHPQWTAAVFITNVSNPTSFDNFTQITPFFQENIEGSFCMAFDLSQTNATGLTNGENVTIQFLFDGGDGNLFQCADLTLDTSANVSSQSCTNATSSSSSGAIGTPVPAVGSLLGLTAGLVGAAFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSS1</accession>
    <name>A0AA38NSS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_253116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="72" mass="8241" checksum="7C840AF3D11C5E46" modified="2024-01-24" version="1" fragment="single">LHRDLSIGNIMFRRKDGKIYGVLNDFDFSSRDMDQGPTSNHRTGTGPFMSTDLLKGGHLFRHDLESLFNIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT25</accession>
    <name>A0AA38NT25_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_383250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT25"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="479" mass="52004" checksum="A308ACFD7734D07C" modified="2024-01-24" version="1">MDQEGPNVTPDRSTSTTNNVLDGLVIERNTSVLTSREPDGGDHSPSPIQDHHNPNVPPFKLVPSEKHISRRTEPPGTLLLWPTHIPPPATSPPSPLPASPDVSAAMVGRPFTSEAAEHFEQIPFDSTINPPLASSLPKPATSLTSDARMEHLLLAARIIGRKRAAFTAGIVDAEWEREQKDRKETEKAKRQKDREKTEKEGAEKLKSGKSKEKTGTVESQALSIRRSGARKNKGKTPAKSDGKALKHTASRIEKEEERITDDEIIISSSKQSRTRQSGRSKPRTLSASSLAGSSQRTQLTGMDSLLSAARSMMDPSISQFTARGEVNEDQIGTVNIAGSRRQVNELVAGSEDTDVLPPAKRRKSLLVDANRPKRTPSALDVLADQAAAAVSTSTISTDRDSMNWKNAKDDLGDEDAEGEYDEEDDPVISTSGTNTNSPAINNEKPRRINLRSTSSRSTTNTRMIMLGKSPIGNLSITPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTM2</accession>
    <name>A0AA38NTM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_102915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="78937" checksum="B3D16951C85B1638" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU01</accession>
    <name>A0AA38NU01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">GGU10DRAFT_301906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU01"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="175"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="396"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
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    <feature type="region of interest" description="Required for oligomerization; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="396"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3791103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="575" mass="63910" checksum="C891AFB35BEC2BC1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU72</accession>
    <name>A0AA38NU72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_391642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
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        <property type="protein sequence ID" value="KAJ3791111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU72"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF6">
        <property type="entry name" value="MAP KINASE KINASE MKK1_SSP32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="40"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3791111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="352" mass="39427" checksum="A8E61AB8F73CB7D5" modified="2024-01-24" version="1">MPSKQDEPLETIRHAIDSMRVTDDEVDSVAQEAVFSDDVLEEICRIGEGAGGAVHKVKDKRTNKIMARKTITTREAPMKQLERELSIMSSTKHINIIEFHGAYMSPSSSEVKLLMDFCEGGSLESVSKQIKKRDAFVGEKIAGRLAEGILQGLAYLHTKKTIHRDIKPSNILLSRRGIVKLCDFGVSGELDGSMAYTFTGTSFYMAPERICGHEYTIRSDVWSTGISLLELVQKRFPFPNDLPPIELMMYITTGEPPQLENEGGVIWSADMKDFIKQTLIVDALTRPTPKDMLSHPWIVENMKQEVDMARWLRQVWGWKKPRDDSSRSRPGTANGHSRPSSSDSASPKAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYN7</accession>
    <name>A0AA38TYN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GGU10DRAFT_304804</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYN7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="209"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="747"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="1012"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ3789670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1165" mass="128303" checksum="FEB4534CFB3C77BC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZP6</accession>
    <name>A0AA38TZP6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_341378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="355"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="378"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="432" mass="46766" checksum="1B7327CAD912D522" modified="2024-01-24" version="1">MSNTSSDGIPQWGTYMREVYLGGKGPEPLGTVVFEEIEKKAIEKLKDQPGSFLYSGGSAGTWSTYTGNTIALNKFRIIPRMLVPCNNRDLRVTLFGVTYPSPLLLGPVGVQGTFTAEGEYAPAKAAAKLGVPFIMSSASTRSIEQVAQASGNGPRWYQLYWPRHEEVTFSLLKRAKDNGFTGLVVTLDTMSLGWRPHDLERSYLPFGHGVGTQVGSSDPVFMARLGRKPTDEIPEFPYDAVAKQKLLVEGDPAAKDAAQLGYAWLAEANFGFYRSWEDVKPLRDNWEGPLILKGIQHVEDAEKAIDIGVDGIVVSNHGGRQLDGAIPSIYALESIMKSEKVRAAQKSGKFTIMFDSGIRTGSDIIKAMALGAQAVLLGRPWVYGAALAGQEGVEQVIKIILADLDVSLAQAGLKGVADVLGRADQILAKVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U313</accession>
    <name>A0AA38U313_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U313"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="99380" checksum="78D80C6AFDEA3007" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U6E3</accession>
    <name>A0AA38U6E3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_431318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="778"/>
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        </location>
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            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1321" mass="141949" checksum="9CB3CE946DF546BD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8D7</accession>
    <name>A0AA38K8D7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_276929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793525">
        <property type="protein sequence ID" value="KAJ3781779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8D7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="141"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3781779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="545" mass="60813" checksum="800F775291F7D4F5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8Q0</accession>
    <name>A0AA38K8Q0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IQ calmodulin-binding motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_363654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793473">
        <property type="protein sequence ID" value="KAJ3782484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8Q0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="747" mass="82128" checksum="207557642110CDD8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBP2</accession>
    <name>A0AA38KBP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_123795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBP2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041337680" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10823" checksum="8F16762345875C93" modified="2024-01-24" version="1">MRLPQMVWSTWLLSTCSLPHHVSPYYSRNQLLQIPCNFLSVRVGGSRFFAVFNDFPMPCPREGSAAGRSSDSPTLWVPNRDIMNCFNNQLSSPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBY7</accession>
    <name>A0AA38KBY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_321236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793651">
        <property type="protein sequence ID" value="KAJ3780808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041269119" evidence="2">
        <location>
            <begin position="19"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="408" mass="41418" checksum="F94D3CB791ED4DB9" modified="2024-01-24" version="1">MRFSTTLLLTAVPLAAYAAPLRMTKRQVAAIDVTVLQFANTLEQLESQFYAAGLSKFQDSDFEAAGFGVSSVAIQQITNIQSDEATHASVLEEELTALGQNPNSTCSFNFDSALTDVATMAATARVVENLGVMAYLGAASLLTDPQLLEAAGSILTVEARHQTILNVLSGSGTAIPSAFDLALTPSEVLAVASPFFSGSCDLGIPANPTLTVTNTGTISQGTSLTFSSTAINSSVDTSTLSCQMMIGGNPFSISLPYNQCVVPNTVNGPVAIYVTSDDNPLQSNVVNRASANNILAGPTVAFIDAQPETLGQMVRSSGTGTAAASSSTQTISPDVAASIISAQGTSSASGAAATDTAASATDSASAAASTSNSVNDSSDPSAPFRDDFTGLAPGGAINVVGWSNIPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC58</accession>
    <name>A0AA38KC58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_118810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793589">
        <property type="protein sequence ID" value="KAJ3781198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC58"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="279" mass="30875" checksum="3694CCF4C9E3DE89" modified="2024-01-24" version="1">MALQTEMSSSSSTSTASSSSSTDSSNDNPDTGSFFTPTSSPPLILAFLAIGLLVTAVIAALGWRRAYFARFRSDVGRQMRRGETQKDPMDIGSRPMLWDLWTTLGTRAVGIKAMETPGMSSEPPRGVSRPVSADQEGVNWETVMPISVTALIRECDGKERSEAAQESPLERTSFLFHVFFQSRELLGSCINYLRYHHRQQDHEDATESSPESEKRFVNPRDGLDRCENLQIAVAIAMPMSKDGKLAGKGDESQPDMFEYSMGICRVSWGGKEKQDLSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC77</accession>
    <name>A0AA38KC77_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_82596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC77"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="639" mass="69161" checksum="A6BDB9A846A8298A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCK9</accession>
    <name>A0AA38KCK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_364807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793504">
        <property type="protein sequence ID" value="KAJ3782038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCK9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="535" mass="61685" checksum="7ECCA8996E23EDA7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE37</accession>
    <name>A0AA38KE37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_276412</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="MU793506">
        <property type="protein sequence ID" value="KAJ3782021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE37"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3782021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="540" mass="61737" checksum="69C8E9516EA03A48" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFA2</accession>
    <name>A0AA38KFA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_44945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793404">
        <property type="protein sequence ID" value="KAJ3783776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFA2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="390"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="641"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="493"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="942" mass="105493" checksum="47FCEDCE1765A40A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFI7</accession>
    <name>A0AA38KFI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_402331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFI7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="434" mass="48391" checksum="8E1DD6A98232E3FE" modified="2024-01-24" version="1">MPSSFQEDSNVVCKICRRQISRYTCPECNIPYCSSTCFKSPAHANCSESFYKKQIESDVRSDSKSKSAEERLKMMEILKRFEEDNSEQGVGDDKEDEDEDEDDLEKRFAGIDIASTSPNTLWSLLSESERDEFVRCLQDPSSNLSQELLLSEELQRELVPRPWWESASEDIPAHSDALIRDAGQSGNDIFYENTYLPELIDIPSTMVKPLPSGPPLIYNLCAICIAYAFVTRRLATSPLAPINADSPSYQDIEEVKRLLAHLVPFLMDRKSTVLHTTVSAAIDDIWSRLDKSTISSSTFTVLMRDTATLLRPLSVGVLSSTSGSSTSTTDIASHPNRTTIYVLSDLSRIFTIHLHGMTRNLHSHIAHKILFYAAHVLSTPPIVLRSLADDLDARARESVEAMQSSSGVTGKAETMDTISKLHSTDSEAELIQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFK6</accession>
    <name>A0AA38KFK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_332108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="220" mass="25304" checksum="2FA541936C3DC392" modified="2024-01-24" version="1">MSRSLFSRDVIGNWSPGMREKIKRRHFPYQQGDSQSLCSYVHTHNRKRHRTCDSQSAVSATKGGKNFFGFHFIYTRHRHDASDESKRKKKTKENEWLQEDDDAKGEKGIKSTEIRMWAEEDNKIAREPEMDSVVPDRAVRSKEVGKMKERETEKSTKVKTGKEGWKKEKRLVAESSLRACSSFYSYGVLLSTPGRVIILPVTIFAPPKTDSQPGSWNAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFS4</accession>
    <name>A0AA38KFS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_400973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793371">
        <property type="protein sequence ID" value="KAJ3784571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000661">
        <property type="entry name" value="calmodulin-interacting protein 111 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="284"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="558"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="792" mass="86533" checksum="E41494A599C22073" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFV4</accession>
    <name>A0AA38KFV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_356973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="339" mass="36976" checksum="1FE549237073F1C8" modified="2024-01-24" version="1">MAFRTIKLGGTASDVTVAPVAHGLMMMTWTPNLISDEQAFEAIKAGVDALPPGTKAFLNSGEFYAMDWGTANLKLLSRFFAKYPDYADKTFLSVKGGVRNGGPDGSMECLRASVDNIQNALGPNKKLDLFEPARIDRKTPLETIMNNLVTLVKEGKFSHIGLSECNAVTLRKANEIYPITAAEIEVSPWSYDDNQKAVIDTARELNITVVAYSPLGRGYLTGQIKSTNDLPENDIRRNLTRFKEDNFKANWAIVEGLNAIAEKKGVTTAQLSLAWVASLGQHMLPLPGSSKSSRTLENLKAGNIQLTPEESKAIHEVITANPTVGDRYFGSDEGAHLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGA1</accession>
    <name>A0AA38KGA1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_347376</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGA1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="50"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3787993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="212" mass="24409" checksum="06D0D83A8335DED9" modified="2024-01-24" version="1">MPTEDEKSLSEGSETVRRANTQSAKQLALALQSAVGLPDAYHCAFWLADELLEDTRAQLWQSIDGNMRELYIDSSMGWNPPEKRQELFHSLARFILLSPVNKPDEVAGYSAFRFEHEAEEDILYCYELQINPLHQRKGLGRFLMNLLEVIGRRTKMKKIMLTVLDNNLAANKFYKQIRFQLDECSPTYEDLDNANGTEKVDVDYQILSKLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGE5</accession>
    <name>A0AA38KGE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_268615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="365" mass="41568" checksum="BF1562E79DE2706D" modified="2024-01-24" version="1" fragment="single">PLTPHPMIPQISSTRDIPTTASHFILPDLISHCNFPLVYHPHGDAVAAQSVRWLDNNCPDLKENRRQALYGLRAGELTAFCYNTAPDERLRVVSDFMNYLFHLDNISDGMMTSDTEALSDAVMNALWFTESYRPTQNLKCMQSEGALNADKLARDFWGRCIRNAGPGCQARFKEYFELFFEAVHTQAKARDAGVIPDLESYIDIRRDTSGCKPCWALIEYALDIDLPDFVVEDPIIMAINRSANDLVTWSNDIFSYNVEQSRSDAHNMIAILMKHHGYTLQRAVDHVGDLCHQTIVDFDASRMKIPCWGAEVDDMVQRYVQGLQDWIVGSLHWSFQTTRYFGTKGQEVKRHRCVELIPVGAGNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGQ4</accession>
    <name>A0AA38KGQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_99014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="82"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="283" mass="30669" checksum="FFF18C2833CAAC99" modified="2024-01-24" version="1">MMIRTSTTLGLMHPQATSPQDMKNISQHIFDQLVHYLKYASSAYTPVCPRPNGSTLITHFSDPVAGIVEGFVARDASRKELVLAFRGSASFADILLDTQVQLVPLVSPGISVPHGVRVHAGFLTAWNSVSVQVLAILAEQLLLHEDIQTIVTSGHSMGGSLATLSAVSAKQRFPQCRVMSYSYGAPRTGNKAFAEFINESLGEDVFRVVHTYDGVPTMISQSLGYHHHGIEYWQNSEPATVKNVVKCDAHGEDPNCSLSIPSSGVNDAHLTYFGIVATTPFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKX3</accession>
    <name>A0AA38KKX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="1">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_368316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="1"/>
    <dbReference type="EMBL" id="MU793632">
        <property type="protein sequence ID" value="KAJ3780899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="48"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="399" mass="43579" checksum="28A665DFC9333585" modified="2024-01-24" version="1">MTAEETLQKRQDDSDSDAEDEDIVENIPKIDIDTSKLTPLSPEVISKQATINLGTIGHVAHGKSTVVKAISGVMTVRFKNELVRNITIKLGYANAKIYKCENEACPRPGCYRSYRSDKEDNPPCERPGCGHRMRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLVAGNETCPQPQTSEHLAAVEIMKLENIIILQNKVDLIKESQALEHQKSIAAFVKGTVAESSPIVPISAQLKYNIDAVNEYIVKRIPIPVRDFTSDPRLIVIRSFDVNKPGAEVDELKGGVAGGSILTGVLRLGMEVEIRPGIVTKDSQGRNKCQPIFSRIMSLHAENNLLEFAVPGGLIGVGTRIDPTLCRADRLVGQVLGAVGKLPKIYTGICSSSLFPLQRKLFRLNARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKY9</accession>
    <name>A0AA38KKY9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793844">
        <property type="protein sequence ID" value="KAJ3780225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKY9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="111" mass="11850" checksum="4FC65239C94D23FD" modified="2024-01-24" version="1">MSTTSSPAHPVRSPTPVLNEEDVELQAFLAAAQREAQEKWEKLQAAKTSGVVGKVVEGEAGVVGLKENVVGGVAEEEEEEVVPKVEPRPRKVVAKMVAGLPRSREVIPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLH4</accession>
    <name>A0AA38KLH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_365948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793534">
        <property type="protein sequence ID" value="KAJ3781664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="267" mass="31152" checksum="054D51F4328FE6F4" modified="2024-01-24" version="1">MAKSAWILRGGVARQKVPTANLRQNRKRMTRIMAVILEMEKKSVKTSLVRMRMRMRMRMMPRVEGIPTLILLPSQKVQSEKIPDVTTIVIRSEPANPPVALTRNWTDPGERDLRRAKAVFTYMGGMNMLGCEADSYTELKRAPRRFRAKRRFDSDDADKAFYRDLESQHYKAAEQMADYAAIFFKKYPNSAEFLAIIGSGPFWRYAVVNRTDCPWPEPGQRLPKEQKITKMDTFFSLFGSEYFEIGTQRSDAEWHKVRQVYFMKEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLJ3</accession>
    <name>A0AA38KLJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GGU10DRAFT_368300</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="MU793630">
        <property type="protein sequence ID" value="KAJ3780915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLJ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="215"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="447"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="513"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="772"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="1032"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="582"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ3780915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1099" mass="123622" checksum="8924235A53CB7E34" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLV8</accession>
    <name>A0AA38KLV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_429967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793560">
        <property type="protein sequence ID" value="KAJ3781425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="551"/>
            <end position="552"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3781425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="661" mass="71666" checksum="0E4AF506E93AEED2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMB3</accession>
    <name>A0AA38KMB3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">DNA polymerase</fullName>
            <ecNumber evidence="23">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">GGU10DRAFT_429683</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76255"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:18657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:195194"/>
            <dbReference type="ChEBI" id="CHEBI:195195"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 23">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="23"/>
    <dbReference type="EMBL" id="MU793505">
        <property type="protein sequence ID" value="KAJ3782025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 23" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 23" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13 23" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 23" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BRCT" evidence="25">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="22">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAJ3782025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="586" mass="66765" checksum="E22420B09DD02952" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMD1</accession>
    <name>A0AA38KMD1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794649">
        <property type="protein sequence ID" value="KAJ3779556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMD1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="32696" checksum="41B2AD72FF0C7CFF" modified="2024-01-24" version="1" fragment="single">QRRTPGDGRVLEGNLWGMTSAGHSSVQADNAGLLIFGTSEPDDDHYGTEDPMLELEGESFFGTRMASRQAKQLKVVHTPQEPPKPSHHPSTYTMEEAEEDPVGVSADGWIWAAGRLSNMNEDEIREWEEISNRVQFFRAEADYETWQEELERKHADFVFLIGSFTKQRDDWAILAKNFSSTPGHVAYAKEHSNMFEALRADAGLKYKHCGIGFLVNTPLGEQLDRRIMAWRAQEEKHFAFDRLSRSSGGGGGPQFRLINLKAKIRHLTVDWTFCALFNCPEYLVFNGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNC4</accession>
    <name>A0AA38KNC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_389232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793428">
        <property type="protein sequence ID" value="KAJ3783255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNC4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041310662" evidence="11">
        <location>
            <begin position="17"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="562" mass="62525" checksum="4917F1EC1D4DAAAA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNF4</accession>
    <name>A0AA38KNF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_414908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793671">
        <property type="protein sequence ID" value="KAJ3780696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNF4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="428" mass="47463" checksum="8677CD38D357B5D2" modified="2024-01-24" version="1">MSTNSSNAETLADYVASQDTLVQEAAEALPHQFSHCTYPLGHLRQAVYLCLTCPEARGICSACSIACHTDHEQVELFPKRNFRCDCPTEAIGHPCSLHTTTEPVNELNWYGQNFQALFCRCKRPYDAATENETMIQCLACEDWFHESCCNLREPPSSEDLPPENKDHGPNGDAVSKASNDLPPALIGPEDYDSFVCSGCVLKIPILQRYAGTRGCFIVVRDLPTSPWKILPDIHTDNHESLKVSSVPESSIHSNKRALSPTGVDGSTVKRARLLPIPSPPDAGCVAPIPNKTAQKFFADLTSSIDPSPALSTGDVFLTDGFRERWCRCTSCILELEAHPYLLNEEETYEPPEDPDSALSLDELGMRALSRLPRERAIDGIHAFNAMKDDLVQYLRPFAQQGKVVNEADVRNFFDGLLEEKRASREHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNI2</accession>
    <name>A0AA38KNI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_53805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793422">
        <property type="protein sequence ID" value="KAJ3783390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNI2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122873" checksum="954B591B1E2B8D04" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPA5</accession>
    <name>A0AA38KPA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_356158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3785009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="42"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="415" mass="45282" checksum="68D398DE1A4E26FE" modified="2024-01-24" version="1">MAPTTMHYINKAAPGSPFYTPLQDPASGTALDPQPDGKPIPKLFTPLKIRDVTFHNRIFLSPLCQYSSDKGFFTFWHMAHLGGIISRGPGLSFIEATAVLPEGRITPEDNGIWDDAHIKGLKEVVDFAHSQNQKIGIQLAHAGRKASTVAPFLHLNANATPVAGGWQPLGPSAIPFSEVNQTPEELTKEDIQRIVKAWADSAKRAVAAGFDVIEIHNAHGYLLMSFISPASNHRTDEYGGSFENRIRLTLEIIDAIRAVIPDGMPLFLRVSASDRIEHLDEPSWTNQDTIKFVSIIAEHGVDFIDVSSAGNHSKQDFSNPHAQQEYAAEISRSLKDNGKHGKIFVGTVGGITSGVQAEKYMQDGVADACLVGRHFQKNPGLVWAFAEELGIRISLAKQISWGFFGRGTGNTSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPL6</accession>
    <name>A0AA38KPL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_319342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793508">
        <property type="protein sequence ID" value="KAJ3781986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="419" mass="47857" checksum="104F3B1F39C79C58" modified="2024-01-24" version="1">MVFPVPREIVDCILDNLYLDKATLLSCALVGKAWGLSAQRGIFQHITLELPIMQHEEFDELARAYNKRNEQLIGFFERKPYLASHVQTFELKQFGKLSRNGSRDKKEILYVSTTQVVERLCNVQSLLLSRGNWDSLSPQLREALKHLFSAPSLSRISISLFAISSFNEFASLLSQVSHLRMLKLHFLYCNNWDVPTSSQNHPPRSIQLDQLLYLHSVNTRAFAAWFQQDSCPLEVRNLRTLQIYSKLTDYEGTAPMLQSIGANLQRLELELQGPHGSQDSTLVHLGFTPNLSSITLANVQQTDIYSPIPWIVCLFEPNQNYDRLRQLTINLYTDHVNILETHRWDEWTTVDRLLAERRFASLETVKIELLGSPILASCDVKEVLTGKMPFLRSSGKLQVETPIEGEVNIDKIKAVISAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPT2</accession>
    <name>A0AA38KPT2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_389982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793489">
        <property type="protein sequence ID" value="KAJ3782241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57286" checksum="91B995B33CBC7562" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPW4</accession>
    <name>A0AA38KPW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_268510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32012" checksum="6371282B99DC935E" modified="2024-01-24" version="1">MLCALGVSGIAFCVVEGRYAKMPIAPGRLFVRWGWRNVPIMMINRTLLFFHNFAMIFYVPIFLQVIGLPTVTSSALIIPFLSMAAISSTVVNATASKYGYVRTICSCGIAIIPIGMGLMSTLNEKSSIGRIVGYSLISGLGFGSATQITMVIAQVGLPADELSTVTALVGAAPTLGGTLGVAVVGTVINNAYKQTVQRSAIASSLIQNSRANTTISLNPSDVVSSISSLAPDSPIRKVLISAYVSAWRKGCYSLVGVAMLQLVLCAMMRRVEFDSSSKDSEGEGSPRSVVVEDAKDNAMVVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ69</accession>
    <name>A0AA38KQ69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_290716</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ69"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="361"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3786194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="470" mass="53323" checksum="CDC77FA4473AA0F8" modified="2024-01-24" version="1">MSDVVTKDSANINDPSATTDSPMPIPDVDNYVAYTIRNTKALPPITWSNLLNEINWLSVYILTVPPLVGIVGAFYVKLQWQTALWAVVYYFMTGLGITAGYHRLWAHRAYNASLPLQYLLAILGAGSLQGSIKWWSRGHRAHHRYTDTELDPYNAHKGFWYSHIGWMLVKPRRKPGVADVSDLRHNPVVRWQHKHYLSLILIMGFVLPSVVAYLGWGDAKGGFIYAGVIRLVFVHHSTFCVNSLAHWLGETPFDDKHTPRDHMITAFVTIGEGYHNFHHQFPMDYRNAIRWYQYDPTKWTIWVLQKLGLASHLKVFPDNEVRKGQLTMELKKLRRTQENLTWPSDSNDLPVISWDSFTTQSEKRPLILISGFIHDVSDFIEEHPGGGHFIRNFIGKDATTAFFGGVYDHSNAAHNLLAMKRVGVLHGGSPHGLDDKRAIPPSQRLKIARYTELLSPGSSSTYSDGEDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQT3</accession>
    <name>A0AA38KQT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MICOS complex subunit MIC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_375340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQT3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12373" checksum="9482DF0190B8A007" modified="2024-01-24" version="1">MSFLLGPVSGALVAGGVYFGFSNLIQARTKELSTDLHIQSTLLLHSPTPSWISTYPSPAASRIEHKPFLSLLQAKWNEQVEKAFVWASQSDKHVSDAAGEFSQWAGRKLTGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR20</accession>
    <name>A0AA38KR20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_435602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1139"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="299"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="708"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1315"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3783936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1576" mass="175638" checksum="4EAD050641526F28" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRH0</accession>
    <name>A0AA38KRH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_27702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRH0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041456127" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21947" checksum="3D853C50CF39FD9E" modified="2024-01-24" version="1">MRITSLFTLLVLSFAIVDAAAVLNVVRSKRQAGGITKSGIRKPLSSLKKASLKKASPKKATVKNPCRGQTLYIMLEYNTAPADLSNESESHEQIVQFLHQPKIWDALDLAKYRKPDSDSSNPHSLLNLRIHGYPHPENDQITLHFSIAGPEKCDGEPYGCKVEFLRQSPESNFLITNKRPGEVAMIYAEEPTRFALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS87</accession>
    <name>A0AA38KS87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF292-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_348183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="267" mass="29660" checksum="1ACC74FDE165E85C" modified="2024-01-24" version="1">MPPWNSAKAKVQLRLSVQRLRTLQAKKEAQAKSSRRDIATLVERGKIETARIKVEAIIGEDIHIELLELLELYCELLFARFGILDQNAREPDPAILEGVCSIIYAAPHTELKELHVLREILMHKYGREFSAQVMENRDSCVSDRVVRKLDIASPFTALVDAYLGEITKAYGVPWYPAAIKDGGDEAEKGLVEASPQFDIALPDIKTEAASTVPTTPKLPDVPPTEDENEKAALPKEGSQGKSSVVKSTTPENDFDLLTKRFAALKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS90</accession>
    <name>A0AA38KS90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation machinery associated TMA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_345237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS90"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="63" mass="6705" checksum="B259542E27E4DF0A" modified="2024-01-24" version="1">MSGRQGGKLKPLKAPKKEKKDDNEDDKAYKEKQKAEQAALKAAKDKALKGGPPGGGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSW7</accession>
    <name>A0AA38KSW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_352479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSW7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="578" mass="63962" checksum="0C7B629D1BF5AD7F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT92</accession>
    <name>A0AA38KT92_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_351159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT92"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="298" mass="31936" checksum="24F87E7FD34F0AA8" modified="2024-01-24" version="1">MLRPIVDGFKLLGNPVNSLVYPFPWFSTLHAARISLAFQSNTYRQGTYTALGWKSYIGGFCVMSWGGMVFSHILLNLPPPVLYAHQVWFNYISIHLFLTAMFSLIPFFLVDADLLSTVDLVLFPLDAMLRVNAVVGTLAHLSPGSPSYELVSPALISSPLFHFILGCTASAGGGVTAATLGVWSPNWGSGGFTPTFLRKGPRSPLRNALSTLDVWGGGLAAIVYGLSTSHTAFHPLLSVLSPYIYAFALVDMHDVKPSSPLEGKSLAAAVLVALFGIRALAAKLQVSAPAPATNKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTM9</accession>
    <name>A0AA38KTM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-alpha-acetyltransferase 60</fullName>
            <ecNumber evidence="7">2.3.1.259</ecNumber>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_433240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50604"/>
            <dbReference type="Rhea" id="RHEA-COMP:12745"/>
            <dbReference type="Rhea" id="RHEA-COMP:12746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.259"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase family. NAA60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.259" evidence="7"/>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTM9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="190" mass="21230" checksum="86649F6F3948FF0A" modified="2024-01-24" version="1">MSDFIIRPLVAADIEKIKKLHARLVPVNYPPSFFLHLLIQHSHSSLIALDPSTDEPVAWVSASLHKSNNHLMIGSLEPHIQLLTLGVLPEYQHRGLAKRLVWEVIASLHDNPSVPVPPVYTHVCTTNTPAQAFYESIGMRFLPGSNPSGAPYVAKNLYKYPPAWARKANHEENKLFESRDAYVLVGKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUH7</accession>
    <name>A0AA38KUH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_319081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793497">
        <property type="protein sequence ID" value="KAJ3782127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="518" mass="57812" checksum="20D64552F0F246FD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVC9</accession>
    <name>A0AA38KVC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_359665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVC9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="313" mass="35433" checksum="0D314399E690F521" modified="2024-01-24" version="1">MAVSVWWIAAAMICPPVALLYDHLLTLDLEVQHIWAQPKRRSAISYFILRYLVSCGEISVLVFRFYTMPSFDTCSRYQMYISAYTSVVEVMVPILLTMRVYAMYECRRYILWTLCITLGCLLPVVVWSVVVSSLGTVLLEGLVCDRFLPEKKATYLAITWGCALAFDTLIFCLIARISFQTRKTYSEMEIQIPLMSLMVRDVPPNNHHHFHSWHSEQATRSSSMTAFTRDLSATMVLRLMLNLHENVSKGVLQTDTSNDEHELNPRSAMMFNTNPALVSGIGTTMSMAQPTNSTATAKSRNLISSRGSIPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVZ8</accession>
    <name>A0AA38KVZ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_11781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVZ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="176" mass="18769" checksum="5D39F76F1F124AA8" modified="2024-01-24" version="1">MSSAIVTVGISGNGSEEVKAHLKDIPKLFLNNRPNSFAASIITRLSLTEVSIKSNAVEPQRKEGLVVHTITVEEDMVNGGGNIHGGCSAFLIDICSTASIMALKISQGLTTLDVSQSLNIVYHAPAAIGESLRIVNTTMTVGRRVASARTEIWSETHHRLVASGVHIKMEPSPTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWQ8</accession>
    <name>A0AA38KWQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_311131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="33"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="388"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="84848" checksum="032CF1761CB92ED1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX56</accession>
    <name>A0AA38KX56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_155887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX56"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44496" checksum="873C1F778D9FC443" modified="2024-01-24" version="1">MTSTNMAAARLPLELQDMIIESILDLDRSYLSLASLVCRDWRNRSYERGFSSIYFSSHSIPVFASFLENPFSRPAIFTRVRRLRILGGGETFIWSTSLLGDLVKLVHHLAQIGRISVLTLDNLNWAVLDPALAAILTDFRATERLYMHRIYFAHLGQFSDFVARFRFLRAFDLQSVEFAARSGWNIHLPLLTPYEFGHCVSLDANNMTLSKRLTWFYPKCISLEQQRLSTVHGAQIFCDSSTGSDLLRNLGPLLTRLDILSESISADETIASLDISTNFSIRHLHLASPARVLSMISWLPSLLARVKSLNLRTLHVSFAQSRQFHLDRSFLKHIAGILAEPQYQELEVIEFIASSARCGRLEDSVKTDIIRCIRSCLPSWDKRGILAFTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXU7</accession>
    <name>A0AA38KXU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyphosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_121873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXU7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="6">
        <location>
            <begin position="144"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="818" mass="94484" checksum="48D91AA9D25344CB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY82</accession>
    <name>A0AA38KY82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_362027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793439">
        <property type="protein sequence ID" value="KAJ3783053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY82"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="357" mass="40336" checksum="38BBCE355CFA9BC6" modified="2024-01-24" version="1">MSGEELNPYELLNVKVESTDQEIRTAYRQRSLKVHPDRNPNNPDAARKFHELNQAYELLLDPLRRLALDAKLRLKQAQKERYKNYDLKRKTMVDELEERERALKKTKSDKQKEEAARSQETERIKDQGRRLREEKLKEFEKKEQEAMSAAKEEQETDAPTLQSTDTTVRVKYSLSEHPSLTTASSLASLFAPFGVMDVDTIVVSLKSPKKAPHKPPKYGTALIPFKRIGDAFAAVCATGLPERGLSGIEVGWIGGSEPEILGWLRKKGHLGPLGSGLSNEPQVQQPEEKALPPQAQSRASGSDVFSSFPSTFPDFSTPGEAPKVKEFDYESLTLMRMRQAERARLEREILEKEGTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYH1</accession>
    <name>A0AA38KYH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_344426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041312656" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="251" mass="26528" checksum="83B48D8A6294FA7E" modified="2024-01-24" version="1">MHYFLLLAVMLHALNLVAGDGITPTAPGPGDKFNAGSPCTIQWEVGENWSNFTISLLSGSNTQMQFVTTVASGLDGSDTSLSPFNWTCPEVDPYSAIYFYQFTNGNDTTNSKWTTRFTIASPSGESSSPANSTQPNGDAIPWGIGSLSNLSATTTTIATSSTISTSSATSGSPSSSSRMRKTRISVTSTERLATPTIVIPSGTTTTDAAATGTTFAAYRPNAQNENGARWNQEFCWWKMVVVPALGFIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYW8</accession>
    <name>A0AA38KYW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793381">
        <property type="protein sequence ID" value="KAJ3784313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041455824" evidence="1">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="220" mass="24340" checksum="65C7CA3588D2304F" modified="2024-01-24" version="1">MSFISLIFSKFFALLVLLTAAVIEVDAVPIFPNAPSATTIHSSAVRVKFPPDDAVTVGYLWVPKEQALELRKTHIFTFELTKDEYLPRLYAKRPMHGQEQYWLCTVSIEEKIVTQAHANRQLITMPNTQVNPSKEARKKYVEANGDDLTTTILLYTASTGPHTGQAPSTFGAVDFPTGRLKQNARELYVSCVDPKTSVDLAAARVPPDDMEAFGVPPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZE0</accession>
    <name>A0AA38KZE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_4378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793343">
        <property type="protein sequence ID" value="KAJ3785408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZE0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="135" mass="15278" checksum="A537C9EA1291840D" modified="2024-01-24" version="1">MPSVTSKAALRKISQSKKPENPLRPVSPEELESWSDRDGDSESTLSEPLPEDLDEPWPYTFHTGQAVWIRTSGGNWHSGRVSSETTRKGNTREKEGLFYPVKFDGKLRKYFAPLNGEIKPDTPHTRRLLKGAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZT4</accession>
    <name>A0AA38KZT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_175888</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="MU793318">
        <property type="protein sequence ID" value="KAJ3786293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000016">
        <property type="entry name" value="Putative Lysine-specific demethylase 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="17">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="16">
        <location>
            <begin position="230"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="439"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="18">
        <location>
            <begin position="593"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="323"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="958"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1615"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1669"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1642"/>
            <end position="1651"/>
        </location>
    </feature>
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        <location>
            <begin position="1714"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1749"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1792"/>
            <end position="1801"/>
        </location>
    </feature>
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        <location>
            <begin position="1811"/>
            <end position="1820"/>
        </location>
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        <location>
            <begin position="1848"/>
            <end position="1863"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ3786293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1949" mass="219333" checksum="5269218A67F9A1B1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1P2</accession>
    <name>A0AA38L1P2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793840">
        <property type="protein sequence ID" value="KAJ3780232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="279" mass="29179" checksum="5C26A7CC10A322B0" modified="2024-01-24" version="1">MSLLRNTLSYFLFLRCLVWAYPQQITDSPTPTAVSTSTVTAVLQTIDLEGFDIGGETLSGFEQDYTTISIVGISTGTGSDGKSETETTYSREILVSDAILTIATDGSLEPNTLVAGNIITYLNTIVENASGYYISEADDITSGTVQYSEGTYETCSFAGPNAVSAGCSDSDYLMRSSTTVYQSLEFSASVGTTTMTLPVQVVATPQVSSSGSATTSSSGASQSNSGVSQKSGCSMIGASLLAYPSYSYLGSCSYLDGIPFAFGKQASYSTVKLQVGSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2P9</accession>
    <name>A0AA38L2P9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793760">
        <property type="protein sequence ID" value="KAJ3780385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2P9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="270" mass="29541" checksum="712AD62D930F8ECD" modified="2024-01-24" version="1">MSSPTAFPPNNPIAVLPGYPISPSPPIQLAAFVLQDLPAVTLDWEKQLFAITRPDNDDLTVSTEEMVSCILASLAMSRRWKMEQGVPARYDEIARTLGSHIPSTSTANFSIIHNGELWKSSQPVTYDCVFSGPQITELAQSGAITGNIYNDVKWAYPKPSRRTTSSDNDSGLLADFFAARSTKSDQKVLLNGIFAAAKDAEWNVAWRAKRNKTPKSLRGSQRYAESAPPFVNAPSTTVSVTEKMKMWRVRSSTRGTEDMDSASEAAGPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2Z9</accession>
    <name>A0AA38L2Z9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_414454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793649">
        <property type="protein sequence ID" value="KAJ3780820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2Z9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="177" mass="20438" checksum="5B7F954B751B8330" modified="2024-01-24" version="1">MADRLNFDPRNIPPPDFSSNTYASIRRALIADADSPGITSEAEAQQLLRDQWEEENGVLRARYETQLEEDQAIAQARIEEAADEQRIKDAERKAKEDKLAKKAEEKRTPLYSFKQGVGVGYIRQQIHPYAKKLMASRKYVPLWYFLPEASAEAKERNKEAIDNNRFQISMDETCRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3J7</accession>
    <name>A0AA38L3J7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_47147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793408">
        <property type="protein sequence ID" value="KAJ3783697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3J7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="260" mass="28064" checksum="D247924BBAF86263" modified="2024-01-24" version="1">MSFQHPRLLNRGVALVTSAAKGAGRAIALRLASEGFKVAVHDLPHNGELLLNVHRNIQRLGQHSVVLAADITEEDQVKSLVEDTHKCLGGLDVMVANTAVRESAPLISTTAEAWNRLFDVNARGVFFCYKYAAQQMISEGKGGRIIGGCSAWGKKGSPFMSAYSASHFAVRGLTESAELHEHGITVNSYAPGQIIQQIDAINSSEAFHQLQPSATLDRGSLAHCETPQAIAHLVSYLVSEEAHYITGQHIGIDRHRALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L599</accession>
    <name>A0AA38L599_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_356102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3784990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L599"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041239008" evidence="1">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="21011" checksum="F7F082BD747B613B" modified="2024-01-24" version="1">MMFSKKFLAACIHLASFLGVFASPLASSPAFQRPGSSQSDVGLGRRAGGNTIPVGITILNVQPTPLYAIVFGGTLAFIRNGDQVAVQNLQRSFMHGVKSLSMKIKIDLDDFSLIASKLEIEGAHDCTWIIEALNYLSIATRSTATRQVGISEKEENEARTWITFKENELKITESCGEKPEIARPATAIHSRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L675</accession>
    <name>A0AA38L675_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="9" type="ORF">GGU10DRAFT_89016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L675"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="203" mass="23299" checksum="C5B3DCC07B42A623" modified="2024-01-24" version="1">MTSQGNAYEVALFGEFFARDLKAILNRITLHSEYSELMHTCEVTFEPIDAQHQRDTGNEPVVLRAKKELTRKDEGWILYSYLKPESVRAHPEATVRPWATCHVVGDALSFAQALGHTRRSQIYKRGYLFRRGTLVIQMFQQEQVDPSTQEHIPAHPDTLWEVEVKTATPIRNTQETPLSQSIDAVLEVQLLMKGLLDLRRQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L684</accession>
    <name>A0AA38L684_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translocation protein sec66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_289438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L684"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="226" mass="24791" checksum="8FC9C515043C4982" modified="2024-01-24" version="1">MASVLVPVAYIIIVFGSLFIISYYYRKQAASRILEPYFPSHPERNTYVTLLQKADPPTPEAVLKSALVRRAIADVFRVMRIREDKPALQNLVQKGSVGDDLLNSLIAAEKEMEAEIIEVMSEANSFVEGWGPMIFPTANEMIANEKMRAVFEQTADRRMELELRYGRKAQNTPTIAPVAVTMTPSNSASSTSPAVPKANGQAASGENTASDGEGPSKSGKKAKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6H2</accession>
    <name>A0AA38L6H2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_308975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6H2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="52"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="342" mass="37822" checksum="32A7CAFFDC53A316" modified="2024-01-24" version="1">MVAAPDSDTSRSSSPISPEAIIGSLAQFPHYDNEPHIGTHFDASTQVSALLKAPNSDQLIKDIATLVSHRGVVFFSSQDLTVQEQLELGRRLGKLSGNPESSTLHRHPISEDTPELGADVSVISSMGGIAKAGYKEKKRASDGWHADITFEPVPSDYSLLKMHTLPPTGGDTLWASGYEAYDKLSPALQKFLEGLTAVHSGEIFIDYAKKFDLKINSPRGSPENADTGLVAIHPVIRTNPVTGFKSLFVNKSFTKRIVELTPDESDNLLEYLFRHVSENHDLQVRYKWKLNDLAIWDNRSVFHTATHDYTAFRQGNRVVSIGEKPFFDPNSKSRREALGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBC3</accession>
    <name>A0AA38NBC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_337085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793707">
        <property type="protein sequence ID" value="KAJ3780541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBC3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="768" mass="84749" checksum="C6DFB439AEFCFF15" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCG2</accession>
    <name>A0AA38NCG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plus-3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_359469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="217"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="553" mass="62334" checksum="171C4BF80B34C9FE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCX8</accession>
    <name>A0AA38NCX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_4271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU793343">
        <property type="protein sequence ID" value="KAJ3785401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCX8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041481493" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="555" mass="59508" checksum="24BC0195F4235CA9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCY6</accession>
    <name>A0AA38NCY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fms-interacting protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_312863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="206" mass="23255" checksum="37BE4053F44B03E5" modified="2024-01-24" version="1">MASDGDQIIENLRALSEPANANSDIQSLLIRSSALVSCLKSLNRAANTATKTKKDETTAARQEMDQSHLGLQNLLYEKRHLEREIEKCRQFASVYQDIPLYTLEEFQGLAPEEARTSEVLEDDHQLMLNRLSFELAERQRLDLKRRELLQAKEELLKQSKANTNTLDGVKGHIDALVKTASEIQKKVDELIQPLPVPENSTAMTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDV0</accession>
    <name>A0AA38NDV0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_287277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3788011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="128" mass="14280" checksum="E8BE693FF297DC12" modified="2024-01-24" version="1">MPALLHNYEVLLDFNNDTSRPVSIQLSQDYGRNTNAIVLLLPSEAVSLILQPGSLYRYAVKINSGSVYKVADVSARSWRDIHCDISHLFSGGSTSRLNTSSASLDGVVVDRLWRDFRVSCFCDDQLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHC6</accession>
    <name>A0AA38NHC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_369795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793843">
        <property type="protein sequence ID" value="KAJ3780227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041289277" description="Glycosyltransferase 61 catalytic domain-containing protein" evidence="9">
        <location>
            <begin position="38"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="10">
        <location>
            <begin position="452"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="636" mass="71653" checksum="74474A4BD5512B94" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHJ8</accession>
    <name>A0AA38NHJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_278466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793624">
        <property type="protein sequence ID" value="KAJ3780947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHJ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="454" mass="52068" checksum="44619B16335EE37A" modified="2024-01-24" version="1">MPDIPFTSRKASVSARITIIGASITGLATACILRRSGHEVLVVEKSDGKYRTDFTFLRSPPNMTRVLQRWGLQPYLAKSGMIVDQFRFLEGQSGKTIGVLKLYEELLRDLMADFLLIHHGDLISIFQDLAHREGVEIRYNTAVVKIERVPLTALLENGDVLYSDLVVGADGPLRSISRDAVLLRQIEELPTQHVCFSFSVSLEALQADAELEGICAQRNWNMWLGDGFVIYGACHVCSLNRYSLCITTEMEGDMTEYQGNWTKQYPVDHFDLKLERFEPRIRKLLKMAEFIIPTCHVYIPEPENLICDLDKVILAGQSAHPTMPDGMHSTAMCIEDVDALDYLLTRIKHIDEIPRVLSAHEELRMERCTHARDWESRKLKMLTLLQGEDRDMRDAKMRCLSECEDMEEKEYAFNDLWGEEVDFYAYDPIEQADNWWSMYGTVISRRPSNTDYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJL7</accession>
    <name>A0AA38NJL7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_387148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJL7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="569" mass="61531" checksum="F7E4C4E5561387E7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKA3</accession>
    <name>A0AA38NKA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_390006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793491">
        <property type="protein sequence ID" value="KAJ3782209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKA3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="371" mass="42063" checksum="8615575BCF650C0B" modified="2024-01-24" version="1">MNSPYPCLALILSPASILWPHRLPSLEDIVFKTTMSSAAAEIAALEPTIIAIGYDLLSTKRYWVAITALWSYEYILTLGNEIQYAWKGRRNLMFWLFFLNRYLCLIIIIITNVAYFTPLFTQEVCYRYGFVEQLETLFMATIAEVLVLLRVHALSGRKQYVLFIAILLIVVQWALLLYQDVLYKNGTSNLAVLLFARELDTSAIPPLPDIDAYRLCIAIPSTQIAQAGETFLSLFIVYDGLAVLSIIYFVSQQAKGFHFVPILELVQRDGLLYFAVMFSSNFVWLMMALHARPSLGFIQNQPAMVISSIMVNRITMNLQKASEEKLEFSRPGSRRGAEDENASTSENDIELGSFRDSYQTSSRRFSRATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKL8</accession>
    <name>A0AA38NKL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_273888</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="MU793427">
        <property type="protein sequence ID" value="KAJ3783273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKL8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="120"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3783273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="517" mass="58354" checksum="64B1B50E6222837A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKN0</accession>
    <name>A0AA38NKN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF4e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_348494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="284" mass="31774" checksum="69B2AEA6B042BBD7" modified="2024-01-24" version="1">MANSYFSNYSQSRFLANSSQMSGGIQLPPSTQIAPKSRVSSSKHFSTSLSSGSDRSSIKEKTSNGSSPDGSEPHPLRNTWVFWFRQQRTPGNKLISYEEGIKKISAFASVESFWSLWTHLAPPSALQPTTDYLLFHDGVRRPVWEDPVNISGGKWIIRLKKGVADRIWEDLVLAVLGDQFNECRQVEENGGGEEVAANWEDGSDSGAELPEICGCTISVRQSEDIISLWNRLDGDVKVREKIRDTIRRVLHLPTSTIMEYKSNNDSMQDKSSFRNSAIDRTPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLG2</accession>
    <name>A0AA38NLG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein priB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_92969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="591" mass="66739" checksum="FFDC39BD14D5C030" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLM9</accession>
    <name>A0AA38NLM9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carbamoyl-phosphate synthase L chain, ATP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_284944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLM9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="85"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="204"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="729"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="812" mass="88805" checksum="C47D30485D69EA24" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLN6</accession>
    <name>A0AA38NLN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_254326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="102"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="207" mass="23089" checksum="51FB96D746855C04" modified="2024-01-24" version="1" fragment="single">NSHYGQSQSSYDNPYHKPYAGPSYAAAGSSSGHSAPVPANAYEYDVGILAQQSVYVPGAMIDKRGGSGGKLAKGGKRTTVLRKGGGKVWEDQTLLEWSPSWFRLFVGDLSNDVSDDILANAFNKYTSFQKARVIRDRLSQKAKYGFVAFSDPEDFLKAWKEMDGKYVGNRPVKLRRADDTAIRPVEIGHRKARQLEKDLKKNRHKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMH7</accession>
    <name>A0AA38NMH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_331988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="142" mass="15744" checksum="098479A0C29E81D6" modified="2024-01-24" version="1">MSPSPSPSPPSSTYKSSPNKESSKNAPLLTPLQRTICARLNTLPGLKKEIAFINEFVDGDEEYISSLNPTSQSTKRLAKKTKAKAKLIPIRNSHAPIVSRDVWNFEHHRIGEVHVDWCVQINQVCERRAALEVGKDVVVDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMI1</accession>
    <name>A0AA38NMI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_374527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="367" mass="41174" checksum="99294E503A37CBBB" modified="2024-01-24" version="1">MSTQCQGCKQTFIGGNLLRHLRNTKNHACVAYANSIEQPQEISPQITRLLNSLLQSSLTAIPSQEQDQLGAPIAVDSSGDFYGDYNDFNHDDMDIGPSHAPIGVSVGHSTGNLLDSESEGSLFSDDDDSELGEDNWEPLHNDSKHLRSPSPELVFPEGYFEPPLQLPKSRLPPVSRSPLICALIEFQGEIVDEYSQYSHNLKAGLNAWAPFGSKIEWEIARWAKLRGPSSTAFTELLAIDGVCEKLGLSYRNANQLNAIIDTLPNIRPKFMRQEVVVQGQAFEMYFRDILECVKSLYSDAEFAEYLKFAPERHFENSRCEDQLYHDMHTGGWWWSTQTTLDTHAGDTLSKQSSISCVYDPWKYTQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMJ7</accession>
    <name>A0AA38NMJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_350104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3787023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMJ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041243241" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="26329" checksum="5CCC0826D09F3F53" modified="2024-01-24" version="1">MYSFPALLVGMVIMMAGQMYAAAIRGFPAGRGNFPKILASTPSDASDPIASIDFYFPFKDLQNQIQLANIECPAPGGSYDQALSLISMNCPSSEAGNVPINPCCTQNMLTDLAGAVECVQSSDTSLASSMRSATKDFIQQCQQAGVNGLSDPLLTSSSIVSSTRPSSSVFPTASVSKSAVSTISSTISSPSPSSSPKPVSASFAPSVTSSSTSIPSPSATSQSSSALKSIPWGPSISMMGTIGMILTTTLATLIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN48</accession>
    <name>A0AA38NN48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_385243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN48"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="460"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="363"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="600" mass="66618" checksum="BD58C77A021C7842" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNA5</accession>
    <name>A0AA38NNA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_279367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793733">
        <property type="protein sequence ID" value="KAJ3780455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="53" mass="6238" checksum="DCF09EA6A8B1672C" modified="2024-01-24" version="1" fragment="single">LDCSPTNRERELGLDRRETVIELSTRGTVHSDIWYLRLSDRAMARSYHLLDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP82</accession>
    <name>A0AA38NP82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_51036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793415">
        <property type="protein sequence ID" value="KAJ3783530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP82"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="60"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="205" mass="23284" checksum="CDA546B54A5DC40C" modified="2024-01-24" version="1">MNPYAYPAPGYYPPPQQYYPHPTSYYTPRYPNQLPPPATNRSTKYPSLHHILAVDCTTLKIDLKQKPRAVINASTFYAYAGMYAMAIPTTHIRLVSKAFPWSIEIKSTTPITCEAIWDALHSALQEHIADSEWGLVVGEKKPRETIEKAAKKRTESDSDKALKRIDWLGDSTIFRGLEKVEEFQKIRLLPGAEPCAETWVVKMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPB3</accession>
    <name>A0AA38NPB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_359351</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793395">
        <property type="protein sequence ID" value="KAJ3783995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3783995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="560" mass="62854" checksum="CDC287D783D91F0E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPK5</accession>
    <name>A0AA38NPK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_387517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041406401" description="Arrestin-like N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="143"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="535" mass="58410" checksum="68D0058F54FAF110" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR52</accession>
    <name>A0AA38NR52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate dehydrogenase substrate binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_260333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR52"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="342" mass="36911" checksum="97A20B6EC1F7763D" modified="2024-01-24" version="1">MYNPGNHTFYRLYGFPIAHSASPSFHNHIFNQLGGNKDYSLFSTSKIIPEMLEEIRNESFGGSSVTMPIKTAIIPYLDGLEPESEASGVVNTIVKVSSPDGPKLIGTNTDILGIQNALLNQLRSQHQGLSISLRALYPKGVGAGAIIGGGATTRSAVYALTKLGLHPIYLVNRASDEVKAVQDAYPGLVQAGSLIHLDYPDKVEDLLAQPDSPRILMIVGAIPAIPPVAKAERMVYTVASALLTLPYHPPPMDTLTKDSLPFPAKRLFLEMAYKPRITPMLKVAMAHGWDGIDGTNAVVEQGFAQQRMWLRGDASADIGSDPAILGPFIEQKARNLIAKMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRA8</accession>
    <name>A0AA38NRA8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_402740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRA8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="49646" checksum="6C11B9DD2A142A0F" modified="2024-01-24" version="1">MDAVPSESLLDFLHTFDDSYHSLELPEDIEHPSNSIPMYYSDSSALFYEESPTPHYQKDPFRHHIGIIVDDANCFPPPSPMSTFTVSPTSSSDYSVRDPYSLMSSPSDSIVTTCSPADIFPGPSLNYQELSPPSFELPSLDMEVEAPFTYDGIRSPIPECGEGCNEWPQWPTQTAPSNGVDDNSAMHDKELPPLSTHTDDKDPCPTSNETDEDRRMRQSADSSFSSSSLPAESKLPESSPSPQSSMPVSVATVSITPKDTDQHQDLVIPVVASHHRAAKRRISYKELDVEDNNDDDPEYKDTHDADNHKDDDFCLKKDAKRAKPKPRKRARTKKNSDEDEPSSASKPHPCQKEGCTERFGRFYDSLRHYESAHTKKQFICERCNTALSRLDALIRHKDSDKCKKRARRAREAKLRNSLKLKTAQLLMYTQYQVKWCEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRN1</accession>
    <name>A0AA38NRN1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Meiotic sister-chromatid recombination aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_431348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRN1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="99"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="629" mass="70759" checksum="BC684C78D5F4C17F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRR8</accession>
    <name>A0AA38NRR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_341778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRR8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="633" mass="71084" checksum="0B751E6F0E2C585C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRY5</accession>
    <name>A0AA38NRY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_259306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRY5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="415"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="799" mass="89466" checksum="9AD8B62ABCACA410" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSL8</accession>
    <name>A0AA38NSL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_341111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSL8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="700" mass="78841" checksum="4AC2E5634E9787B3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT19</accession>
    <name>A0AA38NT19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_340463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="178" mass="19502" checksum="C320302EC2D3488B" modified="2024-01-24" version="1">MSHHLFILSPSDTPIYNLTYSSTKPAPAIISPLSSNLPTWSTSAFAGTLTALSGASSTTQLTTGGGVRIGGGQDRHVIQMIANASLDAVEDVMRKEGTMYLKGVDKFNEWTVSAFITPGNTKFVLLHEAKNDEGIKSFFLDVWELYVKTMLNPFYSNQQVIRSSTFDSRVRASAKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT50</accession>
    <name>A0AA38NT50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF676-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_339757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT50"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="11"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="468" mass="51943" checksum="55C68B7DC4D8DFA3" modified="2024-01-24" version="1">MSSLDSPSISDNSVHLLVLVHGMWGNPSHLAEMERIVKEVQPELHVLLAETNKEDSTYDGIDWGGERVAQEIIQEIAHLRSQGKCVRHFSITGYSLGGLVSRYVVGILSRRGLFSVDSPDYMIPVNFNTIATPHFGLVEYDSLFDAIKRKLGPKLLSRTGEQFFCVDKWGKSGRPLLDVMSDPNLIFFQTLTRFEHVRIYANAINDLTVPYVTAAIETEDPFVEYEKNGLEVDFQPEHYPILASYSLPSSPPPKPQSKSLSSLWSRSSKSGSTSTSASASIPSVISSENADRKPIIQKKTPVLPPFLEFRFPLNILLYASMPLLIPSVLTLALVRLSLASRHSKARITLLEKEDESGQRSLAQALADLERQVEGAVADFIDNSDPSPTLVVPQLHRSAHPILSPLQKTICARLNTIPHLQKERAFISGMRNAHSTIISREPKVWDKNGVGLGVLRHWAGSLLLQVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTA6</accession>
    <name>A0AA38NTA6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1742-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_147278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTA6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="187" mass="21019" checksum="5D4704A2DF947C59" modified="2024-01-24" version="1">MSFTNLYYKRVTGTPKACWICYKPTTTVLATIDTVDFLYACDNHLTDRGFASQVGESSDGTSGARKLGLNPEEIAKVKEEWEDKQKRKAEKEKEKEKEKAKVEKSDDKKDNDERKEGSKASKSPSPKSKSPGLSPPTPQTPSATHQRFTLHRDMFAMRLAEHRKRRQAVQAKELAPRLPGAPRGDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTE4</accession>
    <name>A0AA38NTE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_302503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTE4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="348" mass="38503" checksum="DE9CCA28335DC255" modified="2024-01-24" version="1">MAFGADESKLVSIFIQTLLYGAYTVVFALTIWILVWRRPAGQGINKLMLWISIVMFILATMHICVNYTRIFMAFITYRSAEGGPAAFFNILSNFTQIFGSAIYVTQTLVGDSVVLVRCYIVWGRQWYIVAFPILLLLGSTASGIGILYSFAHIGDTQIFALELQDWIVSFFSLTLSTNFICTALVAYRIWYVNRSIMKFTHRSWNPVMLLVIESGAIYSATLLSLLILYKAESWFQYVLLDAISPIVGLVFSMIIVRIGLGLIAPTGETRNSLRTFPSTTRASGTRHSASYNMHHLGPFIAAQRGVDGLNASDTTPTGSRLSIPPEAACRHKALGLNATVSDTSNDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTM8</accession>
    <name>A0AA38NTM8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ICE2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_103041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTM8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40333" checksum="C4CF2E0351D2C574" modified="2024-01-24" version="1">MSSPLLWRAVSNAAKSLTVAQILLYLPLTLSTLSTPAFSFLSLCHAVHAFIHGTLVLLWGSPNLSVLQLPVHPFLLLLCFNVFSTNVNPWLLTASRWWTYILSLWGPFFVLLEGLSTLIVAQRLGQMGKKLIEQADSEVYQFTLLVAAAVTYVLSAYWCVVAYPAAASSPLSSTFLGVALTALVFLTFIGFVLKKTNIIESSAISLFIAYNLWLCGLDQHQAYFPETASSYVPLFGNFKPLFDALQNFVTNTLPKPLLITLVYRLTILHSASRILPTIGSDKWDSDNSTDEDRPTSTLIRILLNYRQLLFVNVYSHLLLLDQSSAVWWRWANVFFTLVLWGVELVVSSDDDDVVKDWKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTQ3</accession>
    <name>A0AA38NTQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_257354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="188"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="80282" checksum="079C2030FD7B9459" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTS0</accession>
    <name>A0AA38NTS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_104714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3791004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTS0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="1">
        <location>
            <begin position="77"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="418" mass="47768" checksum="B07DD63745A96B91" modified="2024-01-24" version="1">MTTVSLPFPLPQLEPSSAAEPARQHLLSQSRFPFSISLPNLRASHSSKSKRKHKVDHTQQDANLTVGAVAEENSQDPLTIKLTAPGLADDDLYQDKYEWVVLYENQRGVTLFSIPYYSSNSLLPSDPAPFTMPSSVSLKRAHQPNVSLKEYPLPDGNWCWVSNSWMVDMRSDSGEVQHDGFEYNWMFRKHHWHPRVGALSAGGWVRRRRWVRLMMRPGKKRRMVIEDGDVQTPTITSLSLRSSWNGWDKRLSASPSLFTNATDRRDTFYIPEVWQGDADEDWLMCREIMKAAASDGAKLELWKRWLGLSEPTDPPLTNKGKQKEVSDDDKSLEWPSVPPLEHVIAVLRAKLTTILKRFFIFPESRRVFIELMFKAEVFDQVSGLEHSMTLAKALEFWSLSSELGDLSSFVRSSKSMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU03</accession>
    <name>A0AA38NU03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_405931</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="15">
        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3791048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="431" mass="46674" checksum="FE4BF96821CB9336" modified="2024-01-24" version="1">MYRKLIYIPRLVRGLATSSGSSVLPPATLHLKSGQSFLGRSFGAPKSIYGETVFSTSITSYTESMTDPSYRGQILVFTTPLIGNYGVPLNTAPSDAYDVGVVLESQGIQCAAVVVSDVAEKFSHYAAAESLASWCQRYDVPGITGVDTRAITRLLRDQGTTLGRISVGSDASLPAPNATEFWDPSLENLVDQVSTKEPYEVNPSGSIKIALLDFGAKANILRSLIRRGAAVTVLPWNYDFNAVRDQYDGLFLSNGPGDPTHCMEAALKLRRTLEEWTKPVFGICMGHQIIGMAAGLDAYRMTFGNRGHNQPVLALASSGSIKAGRVYVTSQNHQYALKLQDPFPRGWEPFFINCNDSSIEGIKSTAESGKNVWGVQFHPESAGGPLDTIEMFSDFLTECAAHKYGAVPQKNDETVPQMHTFDSAPKIAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZN1</accession>
    <name>A0AA38TZN1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_425201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZN1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="491"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="795"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="839" mass="93725" checksum="A77AA6C2FFEDFF4D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U014</accession>
    <name>A0AA38U014_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_329923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U014"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041386414" evidence="1">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="255" mass="27449" checksum="A0160AF51C8CBBAE" modified="2024-01-24" version="1">MFLTFLLLILNALQTAQAAFIPVSRSSSSSFSNSNEITLPQLDAIINGTTCPLKGSDSLDECRTAAQALPFVNKGFSDYNITSVGEKAALLSLMSFESGGFQFNINHFPGNPGQGTRNLMEFPAVYQYALSTPFLSNQTLALLPNLKKHKGPTSYASLSSLPNTLSNQTKNAIRAVVLGDGLSFASAMWFYTQSGATQIGQPGQGCTQIAGLVQGLQAQTEAGWEHYITDCVGTTVTDERREDYLRTLKILNGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0W5</accession>
    <name>A0AA38U0W5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_281240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0W5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="1">
        <location>
            <begin position="247"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="477" mass="53298" checksum="4C0D057E44A63D84" modified="2024-01-24" version="1">MDFTELYKHSGSLVSFSPGAHFVLNAVQDRVIIRKTDSFQISRTWVIDPTPSESAALFNKQTTKTTRHLAESKSSTISHASWSSDSEYILTASVKGGFVQVFKLRDEEWTARIACGAEGLVKAVWAPDGRTILCFSDWGLRVTIWSLVTGAASYIQFPLYPDKGFDFRADGRYFVLAERHKSKDTLGIYDASESYKLVRHFPLPTSSLSSFALSPTGNHIAVWEGPLEYKLHILTLAGNCLAGFSPEPEPVLGIREVAWHPTGMFLAVAGWDDKVHILDSLSWSPVTTFELSSRISAEVAIWREPSKWLESTQGRGFLSYEKLRGPQTITLNKTDHTKANPKSVAVQLAWNQTGSLLLVRYETTPTAAHLYLFPSPNEAFVPRLRSVLLHSQPISQARWNPARKGSLALCCGNRSVYTWSDEWENESGEQEEIAECIGVPAREFDTRNICWSKDGKGLILMDKETFCCAFEVEEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1C4</accession>
    <name>A0AA38U1C4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_302277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1C4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="72502" checksum="3ABC3D6681E30CC5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U5B0</accession>
    <name>A0AA38U5B0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_59776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U5B0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000400">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="197"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="288"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="456"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="547"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="703" mass="74063" checksum="F803A255960B88EE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U5J5</accession>
    <name>A0AA38U5J5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L6, alpha-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_49447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U5J5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="191" mass="21305" checksum="AE3D66EE8AC1F5D7" modified="2024-01-24" version="1">MRDVLQTEELVIPEGVTVALKARIITVTGPRGTLTKNVQHVNMDIRLVKSRDSKVTLAVWQGGRKHVACLRTIKSLISNMINGVTKGFRYKMRAVYAHFPINCIIQNDGHSVEIRNFLGEKTVRHVNMLDGVVVAESKAQKDELILEGNDIDMVSQSAASIHGVCRVRNKDIRKFLDGIYVSNKGVIVEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K867</accession>
    <name>A0AA38K867_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_112853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793569">
        <property type="protein sequence ID" value="KAJ3781359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K867"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041412440" evidence="3">
        <location>
            <begin position="24"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="382" mass="38625" checksum="A4ADCF069A111EFE" modified="2024-01-24" version="1">MKGSRSLLLSCLLAFALVHSASAAHEANLVARIDILPTGTDSSSATSATSATSATSATSATSATTSSTSSTSSTSATSQTSATSATPTSATAPTSAGETSQTSAQSTPDNTQSSSAAPTRSVVTSIDSDGGTIVVTETIPPTSATSASASSSATSGADTSNDDDSSGLSTGSIIGLSVAGGVAVLGIISFFIWKFTRKRFSDFDDNEAIKWPELNAHSSDGGDSHPLPVHNTGRSGFDTGSEVSLSRAPSTNTHTNYSTPDLGNDPYAVPPLPHLNPNQPIPYRDDPSASAAYYDPYRGPVPGTFNEPASAAEWGPHPGEAYPMTQMGAAGVSGRASPGPSMMGRMSPAPMYDMRGPSPAPPMAMGRASPGPQAVYDNYGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8Z1</accession>
    <name>A0AA38K8Z1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_361611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793432">
        <property type="protein sequence ID" value="KAJ3783189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8Z1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF90">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="56"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="785" mass="85177" checksum="74F6805B89916A96" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9J1</accession>
    <name>A0AA38K9J1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_388397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793381">
        <property type="protein sequence ID" value="KAJ3784314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9J1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="605" mass="66933" checksum="37E12A28D6623729" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA30</accession>
    <name>A0AA38KA30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_269328</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA30"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3785364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="643" mass="71242" checksum="366382EC96324F1F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAV2</accession>
    <name>A0AA38KAV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_162452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAV2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="460" mass="50838" checksum="DB0CB4AA64E645B4" modified="2024-01-24" version="1">MFLRRLSLPVISRFGVTYKRLASTKSLKETIEEVIPVKQAHLKKLKTEYSDVSIGDVKVGNVIGGMRGLRAMLWDSSVLDPEEGIRFHGLSIPDCQKALPAAPGGKEIIAESMLWLLLTGQVPSAEQTQQLSRELAQKGNLPPFVEKLIDSLPGTLHPMTQLGIGVAALNRDSSFQAAYERGIKKSEYWTYTLDDSINLVARLPALAARIYRNVYKPGAALPEIDPDLDLVGNYSRMLGYGDNHDLTEYLRLYISIHGDHEGGNASAHTAHLVGSTLSDPYLSYAAALFALAGPLHGLANQEVLRWQLSMLKEVGEEVSHDTIREYLWKTLKSGQVVPGYGHGVLRNPDPRFIALQEFCESKPELLSSPIIQLVKKTYEVAPNVLKEHGKTKNPYPNVDAASGCVLYHYGLTEFKYYTVIFGVSRALGCVTQLVWARALGLPLERPKSYSLEAIEQLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBF4</accession>
    <name>A0AA38KBF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBF4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="746" mass="83438" checksum="4DC1F4C0FDC257F6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBV0</accession>
    <name>A0AA38KBV0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nucleoporin protein Ndc1-Nup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_113882</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3788334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="680" mass="75641" checksum="508786DD8EBA9001" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCY7</accession>
    <name>A0AA38KCY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_297452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793459">
        <property type="protein sequence ID" value="KAJ3782698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3782698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="64" mass="7384" checksum="C1A636001E4CCCAB" modified="2024-01-24" version="1">MHLMYTLDEVGNRVYTLKKITESGKITKSAHPARFSPDDKFSRHRVTLKKRYGVLLTQLPAKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDW0</accession>
    <name>A0AA38KDW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_366286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793542">
        <property type="protein sequence ID" value="KAJ3781601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="114" mass="12919" checksum="0EE88A3415261577" modified="2024-01-24" version="1">MYRLFLSLFRLSFAPLSKFSQSDFLVADSFYFLFQVTPSIHSAHWAPPDIIRMLREVNGVLEQTGEFIGSFNVCPYRSTYASDANKFVLGCPKFFSAAVTASGYKFKFLGCRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE09</accession>
    <name>A0AA38KE09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_294162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE09"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="285" mass="31929" checksum="D152DC2B24ADD9C4" modified="2024-01-24" version="1">MPLTFQDFSAWIEVDGSELPIFDIKQTGNEVTCWIPSESEKKFSVKLSTGKRAISMVGDIFMDGKCLSGKTMKAGEPQTFTSSGVLTTATSERPFVFSKLELTDDDEYLNMATAGLGDVKLVISHATFGVTRDHKRYKNCDTIGKVHEKSKKATGHRVGLGAEKPVVYTKSISVRRHAALVKFVFRYRPIDMLRANGIAPLEERKKRIASPSEPEVLDLTGDSDDEEERRMNTLREELQALERKRRKTKHVKSEPGVEPKHEPGTFSSRIKRGSRKVSPEVVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEY9</accession>
    <name>A0AA38KEY9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_361181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793424">
        <property type="protein sequence ID" value="KAJ3783341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEY9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="366" mass="42067" checksum="8D5A6FA12C2CE414" modified="2024-01-24" version="1">MPSPIIPQIPHYEPAPVTTQPLDYADLAIIDLSQGNTVEGRAQLALQVRDAMSTNGFFYIVGHGYSTDQMKRMFDIADVPFSQVSDEEKQKYVAPTKQTGSYQGYKLRQYWHIDGGVRDQIENYNINRDVNRRTHPEAVRPLLPEISQFARHAHMNVLNPILRLMALGLELPEDTLVNMHGYDTQSETYVRFMKYYPRSAEDEEKTKSVWLKGHTDFGTISILYSQPVAALQILARDSTWKWIKHIENAIVVNAGDAMEFLSGGFYRATIHRVVQPPPDQQRYTRLGIFYFCMTDDDVKLAPLVASPLLQRMGFKRWFEKDEDAPLMVDWRKARTSAYGQTTLSKSDKEDKVEEEVINGVLVRHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG30</accession>
    <name>A0AA38KG30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793353">
        <property type="protein sequence ID" value="KAJ3785111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG30"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23066" checksum="2E534D8498C5B7FD" modified="2024-01-24" version="1">MGRLYNQNHACYIRKTSSQINPNDSLRRSPRISDAKKAADKRDNIDKRKPPPEVFRAYVGNIHPLTTIVELTDCFERCDGLSEVSLRIAQGSAVQATPDTPIDDLDVQYAAVTLTKWNGLVQVMKMNGMTLRGRRLVIGLTSAILPEMDRIIYEHYHGVGSLRRKIYGGRPLRSEPTEIITEEVKHGNVVIWSLLQSSPMPITLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGS3</accession>
    <name>A0AA38KGS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_332419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38849">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38849:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041372045" description="Small secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="18528" checksum="107DFD145A605EE8" modified="2024-01-24" version="1">MARFTLIALFGSLLAGIASAAPVPVKLELAARANATGTFTEQDYSAFQISDGVGGTAVDEANAVFVDPFDGVDLSTVSSDTVEAINTMREAAESAETDDFDPQIDAATGATADALSVGKTKNKVLKLTGEIQAINIKIAQAQASGADTSDLEDSLNEEQTKLNTNIAADKANAGKTSQGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHL1</accession>
    <name>A0AA38KHL1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin cytoskeleton organization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_347808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHL1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="931" mass="105861" checksum="A8E113C8016AFD6B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKH7</accession>
    <name>A0AA38KKH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_322090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794750">
        <property type="protein sequence ID" value="KAJ3779505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="178" mass="19923" checksum="6A5C694352A6EA9D" modified="2024-01-24" version="1">MALCRRCFIQISALSTFDGRIEAYHGFNGEPEKRLPHPRKAAGAQITQSRHGEVVTINNNIGLFRYNLNPLTRNNWRASLVPAAAVIPAPIAYIKVVAVKKLVVELQAWSGGPPHGVYCLTESYLLVSRCALYWCASGNQDFYLEKIRVFKAGLCLNTLAWNNKIGRAVLFCWFLESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLW5</accession>
    <name>A0AA38KLW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis protein SPO22/ZIP4 like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_299606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793557">
        <property type="protein sequence ID" value="KAJ3781455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLW5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="972" mass="108186" checksum="E8ECF3C853EA27C3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM80</accession>
    <name>A0AA38KM80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_91979</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MU793512">
        <property type="protein sequence ID" value="KAJ3781935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3781935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="476" mass="53362" checksum="F32D539318A3C540" modified="2024-01-24" version="1">MTSNPTFFPEEMSSDPTAPLSIHDLAKTLADTSLADSTANPTTTTGPALSVPTNSSNAPVVQSAPADASSHDQVVTPWDVQGSVSNDGKQQAIDYGKLIVQFGTRRIDEALLQRFEKLTGRKPHVLLRRGMFFSHREFDKILDRYEQGKPFFLYTGRGPSSDSMHLGHMIPFVFTKWLQDVFDVPLVIQLTDDEKFLFKHELKVEQTKAFARMNARDIIAVGVNPEKTFIFSDYDYVSGPFYENVSKISRQITYSQAKATFGFNDSDNIGKIHFASIQAAPSFSNSFPQIFGTVSNVPCLIPCAIDQDPYFRLTRDVAQKLKYPKPSLIHSKFFPALQGPQTKMSASDPNSSIYMTDKPAQIKNKINKHGFSGGQETEEEHRRLGGDTEVDVAYQYLTFFLEDDDELAKTGEDYRAGRLLTGQLKAKCIQLLQQFVSEFQERRAKITDEQINMFMDKTRKIVPTTSKTLTQPGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM84</accession>
    <name>A0AA38KM84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_362725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793453">
        <property type="protein sequence ID" value="KAJ3782789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="308" mass="33926" checksum="97A879DE3C9C4411" modified="2024-01-24" version="1">MSVHFPSSSDSISRARFTNARRVPNDKASNRHMACVGEGFADKVTFCSSVGNTYTTVTFTPPARRVRHSDAADSFPSRARFNRLAENEEVKAAAGVETKMKKGYSQMFLKKVRSLLNRNSVNNPKGSSQPPHAVSSVSGQESRPPLTNSQSVPATTASLHRFPKRTVRPMASVATIACTRTQGSSNILNSDNPSVRRAREPRSRVVRRSRSFDDAECSSLAACIALDEAVRDLIARETAENQQRDNEVSSTNRTPREDSDIVTDDEETLQNHGSPDGGVWILEDLMDLLKAENDQIAALLAEDEDRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNG6</accession>
    <name>A0AA38KNG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative peroxiredoxin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_272017</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNG6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="172" mass="18634" checksum="20A6508A85881E71" modified="2024-01-24" version="1">MAPTIKVGDTVPDGTFSYIPYSPELDSHAACGVPTKLNISKDWKGKKVVLFAVPGAFTPTCHVNHLPPYVEKYDEFKSKGVDEIAVVAANDAFVMSGWGRFEGLKDKILTLSDPNVEWSKKLGLDLDLSALAFGTRTARYAMIIDDLVVKYVEVEPGTEVTVSGAEAVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNL4</accession>
    <name>A0AA38KNL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_380098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793633">
        <property type="protein sequence ID" value="KAJ3780891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="153" mass="16766" checksum="C45868D0B0BF383B" modified="2024-01-24" version="1">MTGQRTGRNVPSITVDNSSLFKASLTVRVTSAHLHIPVNIRVYHLSVHTYLSWNTILQEYFHQESGKIWPGYAASLSGCSMHGWWTECSECLSYGSCPFITLLSYWTTLFANASLRGTPPVRALFALGKQSLIGGDVSAMPVEGHFPGCGQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ27</accession>
    <name>A0AA38KQ27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4">3.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endo-1,5-alpha-L-arabinanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_182024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4"/>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ27"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08998">
        <property type="entry name" value="GH43_Arb43a-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041419135" description="arabinan endo-1,5-alpha-L-arabinosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="32932" checksum="EC95D400F4B7A438" modified="2024-01-24" version="1">MWLSLILFCVALCSTTVYAYPNPGVVTGDTAVADPTMCKDDAGTYFIFSTAPGIQILTSTDRTAWTYAGLVWPDGASWTDAYTGTSNGNLWAPDCTYVDGQFYLYYAASSFGSQNSAIFFAKSTTGASGSFTNEGLVTSTVTGDTYNAIDPNLLITGSTWYLSLGSFWDGIVGEALGSSTGKPSGSSVTSLAERFVNSGAIEASVIFQYGDYYYLFSSWDICCDGTSSTYNIRVGRSTTYNGGFVDADGVALTDGGGTLVLESHGDVIGPGGQDLMTDVDGVVIVYHYYTSTGTWLGINLLDFSTGWPVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQD5</accession>
    <name>A0AA38KQD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_377978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793437">
        <property type="protein sequence ID" value="KAJ3783081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQD5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68110" checksum="3AD4699ADA721DDA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQS4</accession>
    <name>A0AA38KQS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn finger family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_161667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="681" mass="74589" checksum="36C07EE35C173BD1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSD7</accession>
    <name>A0AA38KSD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_409003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="100"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="363" mass="40055" checksum="64BB69753D979D1B" modified="2024-01-24" version="1">MSFLLSIFKPIAYISLPVILVRTAVSSSPMGLYYFRRGLYLGCMTAIATWGIVVAATMSATGYRYDVNWVIARAFYAVAGTVMGIKVEVEGEEHMLTKPAVLLSNHQSMLDILFVGRMMPKRTSIMAKKSLQYTPLGPFMSMSGAVFIDRGNNARAVRSLEAAGQLMKDRKISLWMYPEGTRHLSKEPDMLPFKKGAFHLALQSGIPIVPIVTENYWRIYRDGFFGTGVIKIRVLPPIPTEGLTVNDVPALTERIRDQMLDALHDISVKVEVPAEEPRGPQPTIPNEIQSDPSTFLSSPNTEDEGAFSPPDVNPEEILEATRTSSVASISSSDSNHREQRSEPSENGAETEEDEGMVLVGRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTE3</accession>
    <name>A0AA38KTE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">GGU10DRAFT_384420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTE3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="658" mass="73041" checksum="B84B40C2E25EEF87" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUC5</accession>
    <name>A0AA38KUC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_346466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUC5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="655" mass="73053" checksum="0B4C7C8130659C72" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUQ2</accession>
    <name>A0AA38KUQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_285254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUQ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="200"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="575"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="867"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="919" mass="97568" checksum="76CBB5BE636A037C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUQ4</accession>
    <name>A0AA38KUQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M protein, serotype 2.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_82934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="82324" checksum="0C7CB512533B64FA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUR8</accession>
    <name>A0AA38KUR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUR8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041431112" evidence="1">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="196" mass="21521" checksum="1BC45AC61E04A56C" modified="2024-01-24" version="1">MHFQKLLAVCILLISCHGAIASPLNIGGASPGGGLRAVTSNTASSDDDKVVELERRAEDKKAMVAIGWVISGRNLRNYGVVFHKVPHSIVKRDDGKLSYYELSGHELDEVRFLDSKVQFTAPIDVTAEISALEAETEGVTGCEWIMKALDFWQRRSGHEDSHLAKQDLGRSIAGRERELHIIPSTCDVNLLSTVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUV9</accession>
    <name>A0AA38KUV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_317923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793451">
        <property type="protein sequence ID" value="KAJ3782832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUV9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="314"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="412"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="501" mass="56961" checksum="48C1AA733105608C" modified="2024-01-24" version="1">MRSPSIYSQDDPLSEALKPPESETEAEREARLEQEAEAKRVSEQIDEELRLERESLKKKRGDVKLLLLGQAESGKSTLQRQFQLMYKPHSLEQERASWRTVIYFNVVRSIKHILNTLESWDDYVDDDVAFDSPISKYMGASRSGTSSPVITNLPSENDRAHSRSASPFQGNAETSRSNIASLRRRLSPLIGTDAALADRLSGGITVSGSGKGGVFVRSGWQARTIENPLGRRRGRNPDELSAKKPDDIHDALVQDVSHMLDASKDDIRELWAHATVKELIAKRRLKLDEWSEFFLRHISRVAASDYVPSTDDILHARIQTMGVAEHVFDVNIHGKSVSWHLFDVGGARGQRHTWVPYFDDANAIIFVAPVSAFDQYLEEDPRTNRIDDSLQLFTQICSSPLLKNAHLVLFLNKTDLLRSKLDNGLRVKKYITSFGERMNDYETVVQYFRAHFLQVHRRNNENRRVLYTHFTSVVDTKATQRIIGNVRDSIFRGYLQSAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUX2</accession>
    <name>A0AA38KUX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_362439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793446">
        <property type="protein sequence ID" value="KAJ3782907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUX2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="740"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1214" mass="133758" checksum="09C036A4ECFBB007" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVG3</accession>
    <name>A0AA38KVG3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_315555</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MU793390">
        <property type="protein sequence ID" value="KAJ3784092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVG3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3784092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="50220" checksum="689B980C332FF4E8" modified="2024-01-24" version="1">MPVSSIITNIFCSFHNVLILSIFIRVALILYSEWHDARSLVKYTDIDYHVFTDAARFFIHPGPGDKNKAQGYLGYLANFGDPYSRETYRYTPLLALIVSPNDWLHPSFGKYLFAACDIINGIILYNLLISSILPKTHNVAKIATTYTALHLLNPMVFSISTRGSSESILSLFVLLTLYGALKNRWDMAAVMLGLSVHWKIYPVIYGFSCISALANTKHGLGRLLNWKIVRFGVLSVSTFLILSGICYLIWGYPFLYESYLYHLHRLDHRHNFSPYFYLTYLTYPSLHEDAYNLDSLSTWNRVLQSPLTSFMPQMTLAVGTGLLFGKSKSHLPFAWFVQTVLFVVFNKVCTSQYFLWYLLLLPLVLPRISMSRTKALACVAIWVAVQALWLSEAYRLEFLGSNVFYGLWIRGLIYIAGNCWVIAQLMQNYDIELGTVQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVM1</accession>
    <name>A0AA38KVM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_314978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVM1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="188"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3784452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="457" mass="48952" checksum="33E2D29BD86FD376" modified="2024-01-24" version="1">MSQLPSEPEFEQALAELTTSLSSFLKAHPGYQKALDTVQVPERVIQFRVVWEDDQGQAQVNRGFRVQYNSSLGPYKGGLRLHPSVNLSILKFLGFEQTFKNALTGLNMGGGKGGSDFDPKGKSDAEIRRFCVSFMTQLSKHIGQDIDVPAGDIGVGGREIGYLFGAYRKLRNEFAGILTGKGLHWGGSNIRPEATGYGLIYFVEHMIQKACPEYSLSKPSTLVAISGSGNVSQFTALKVIELGATVVSLSDSKGALIATTDAGFSKDIIESIGQLKLKGGFLESFTDFADGANYTYHPGQRPWKHLTKVHIVLPGATQNEVSAAEAEALVKSGVRIVAEGSNMGCTKEAIAVFEASRKKGGAGVWYAPGKASNCGGVAVSGLEMAQNSQRLTWSPEEVDAKLKNIMTDCYHTCLSAGEKWSGEHNAGSDVLPSLLAGANVAGFIKVADAMKAQGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVU3</accession>
    <name>A0AA38KVU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_333617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVU3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041380163" evidence="1">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="133" mass="14916" checksum="8A684E5D6086951B" modified="2024-01-24" version="1">MKYTSFAMNSFAFFLLTIFFTISNAFPLSNSMNKRDVFVPPITYPTNTTVWNSGEVHNVTWDISQAPVNITNKIGRIQLRQDDITFPLVLAYDFDILLGSYNITVPLVISGAYQLVLFGDSGNFSPEFTINGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX70</accession>
    <name>A0AA38KX70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_288847</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX70"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="216"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="391" mass="43380" checksum="68F029B0E3FF9B9C" modified="2024-01-24" version="1" fragment="single">MFIAIIGTRGSGCSTVENYLLSSKGFTSIQLASPNEDPSSAFDYPRKVPQDHTVDNTAKHLSFLTFDTTPLPSPSPISGDDESPVKDSTEHSPLIFRNPAEVLDYVTRNWRSNFVTTELKTRGVIEMFIKRPFFMLFSLDGPLLERYRRSSSSLSLQTFAAADDEQRFGKRDSSESFNGMTDLVNVRVDNDFPSKHALHAHIESLDLLNPLHLRPDWDMYFMTLASLASQRSNCMKRRVGAILVRDKRIVSTGYNGTPRGVRNCNEGGCLRCNSGSEAIGDNEECVCLHAEENALLEAGRDRIGRGTLYCNTCPCLKCTIKIIQTGVDCVVYNLSYKVDAASAKLFAEAGVKLRRFDPAQHRLSTLPSDADGNYDTSTIDMTLDDESLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXB4</accession>
    <name>A0AA38KXB4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_410409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793528">
        <property type="protein sequence ID" value="KAJ3781748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXB4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF218">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="518" mass="58445" checksum="E219E6EDC260D318" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXZ2</accession>
    <name>A0AA38KXZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_318098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793458">
        <property type="protein sequence ID" value="KAJ3782723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="687" mass="80193" checksum="C41AD92592288A11" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYE0</accession>
    <name>A0AA38KYE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793428">
        <property type="protein sequence ID" value="KAJ3783263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYE0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="125" mass="15575" checksum="9FE1950CF3025020" modified="2024-01-24" version="1">MPRKRTASAIYKSERSEEQKLADKAKTQRLVERRYRRKCYYISNRVRRKNPEKDAERMAKKRKEMTDDERLLEQESKRKYNATYYQKHREDILVKHQRKRTTEYISKHGEQAFWLHHSPRETFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYE6</accession>
    <name>A0AA38KYE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_78646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="7"/>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="757" mass="80329" checksum="2CBADDFA9CB7CA0A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYY8</accession>
    <name>A0AA38KYY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_357891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793377">
        <property type="protein sequence ID" value="KAJ3784433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYY8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="268" mass="29610" checksum="5951130FEFCC56C9" modified="2024-01-24" version="1">MVTGSFKSQDWVSSLTVSSYDIVAFPERVPNRYIKCHSKGRLSFLTMLRFWGFLFIAFCCLSFGSSLGRILEKRDDNLPARVPYVFPPPGTDPIADAIRARRTNGTLLDLDGVLLNAPLIAQGEDILFGVIRDNNTLPPAMRELFILRIAVLNNATYEWLQHESVGRMAGLTTEQLLAIRLAPPFFASQGVNLTSILGPDLVAAMTFTDWITKNVHVPDDVFNALRTFLNDSQLVEATATAAGYSFISRFVVALNVDAKMDVPVPIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYZ4</accession>
    <name>A0AA38KYZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_28194</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793375">
        <property type="protein sequence ID" value="KAJ3784478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3784478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="445" mass="49897" checksum="F825C9681D5F81B8" modified="2024-01-24" version="1">MREIVHLQTGQCGNQIGAKFWEVVSDEHGIEPDGLYKGNNDLQLERISVYYTETGANKYVPRAVLVDLEPGTMDSVRSGPLGGLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEATDCLQGFQITHSLGGGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTPTYGDLNHLVSLVMSGITTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMTGFAPLTARGSQQYRAVTVPELTQQMFDAKNMMAASDPRHGRYLTVAAVFRGKVSMKEVEEQMQNVQNKNSAYFVEWIPNNVLSAQCEVAPRGLKMAVTFLGNSTAIQELFKRVSDQFTAMFKRKAFLHWYTQEGMDEMEFTEAESNMQDLVAEYQQYQDATVEEEGEYEEEQPEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZ28</accession>
    <name>A0AA38KZ28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_293646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZ28"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="213" mass="22197" checksum="682C129A336B3469" modified="2024-01-24" version="1">MSEIKGPSPDAKVDGSSLRIAIVHARWNKVIIDALVAGALKNLKEAGVKESNIVVESVPGSFELPLACSRMIAGSHIQAASNEADLLGGLNFGSGSGILSPKLPSRSGTPAPAIPSANQAFDAVIAIGVLIKGATMHFEYICDAVSHSLMKIQVDTGVPVIFGVLTALNDDQALERAGLGKGDKTGHNHGEEWGLAAVEMGSHVRRWNSGKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZA5</accession>
    <name>A0AA38KZA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_387716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="34129" checksum="B44F4929E30A4F15" modified="2024-01-24" version="1">MSRSPQDLTKTHHHDTYPAISPKKPTLSQAGRSVLITGGGGGIGFEIARSFAKAGASRVIIVGRRSSVLDAAAVKLREEFKDSSTEFIARQGDIGDDASVSSLWDFLHSQNIFVRVLVLNAAHVTPWGPDTLKMDKRELMEGFDVNVGGNFVMMVKFVNQPLRPTGQQLNLIYVSTAGIQMIPAPNQTPYTTSKAAITALVGRIADEHPVEDIQIISYHPGVLYSEGASKFVDKSLLKWDEMALPADYAVWAASPEASWLHGKFVWAHWDVDELKADKDISKLMEQEKGFLRVAVQGLTEVSLEGIMNKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZZ9</accession>
    <name>A0AA38KZZ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Linoleate diol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_374494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZZ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117479" checksum="29DE3DDD62B0EE18" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L030</accession>
    <name>A0AA38L030_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L030"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="81" mass="8640" checksum="D2B2D136EA1A8F92" modified="2024-01-24" version="1">MPNNNSSSSGYTYNSSGNNSQGNHYCSRDYGNGSNSYHYSNSNGSYYYANPNGSTYYNSGTGHSQYTSPSGQSGNSNSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1K4</accession>
    <name>A0AA38L1K4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_280242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794170">
        <property type="protein sequence ID" value="KAJ3779827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1K4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3779827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="64" mass="7122" checksum="7952B17D3D50BC12" modified="2024-01-24" version="1" fragment="single">NVKNCPLCKVHIERAEGCNHITCIHCQTHICWVCMQTFPGGDGIYNHMRAEHGGIVNAFNDNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1P0</accession>
    <name>A0AA38L1P0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_162086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793858">
        <property type="protein sequence ID" value="KAJ3780202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1P0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="31838" checksum="5F898315B8A6BE8D" modified="2024-01-24" version="1">MDPPRVWFITGTSSGFGRRLVPSILRRGDKVIATARNIQSLHHIFPPSDNLQILELDISSDEATIKLKAQQALTFWGKIDVLVNNAGYSLKILVEDATLADFQTQFQTNFYGPAALTNALLPQMRSRKEGTVVMIGSRSSWNPIPALSIYAASKAALRVYSETLAQELSASGFPNIRLLIVEPSGFRTEQNVLGYPMQVPTSPDPAYDSLRARIQANLEALDLNQSGDPDKAVELIVDVVRGEGQAEGKDWSLYLPLGRDANQDIGTKCGKMLTAVKTWREVTDHLDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2F7</accession>
    <name>A0AA38L2F7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_232260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793513">
        <property type="protein sequence ID" value="KAJ3781927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2F7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="18614" checksum="CF13F2164F359D60" modified="2024-01-24" version="1" fragment="single">PLPSPPKQVLTDPETQLALSRHSNFIKIQTPYDVDKLSTLLLLHPNRPFVESVLNGLKHGFWPCHSGEWKDKSEFFDNYPLQPPDEDALKLYRDKEVEAGRWSPPIYKLSPGMKLSPMFVVWQGETNKARVITDQSASGLNDGVSKEDAHVRYDDMHSFGAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3Z5</accession>
    <name>A0AA38L3Z5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_357582</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 12"/>
    <dbReference type="EMBL" id="MU793373">
        <property type="protein sequence ID" value="KAJ3784522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3Z5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3784522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="377" mass="42502" checksum="F22B23F79FD343D7" modified="2024-01-24" version="1">MSFVKLSIFGTSFEVTTRYLDLQPVGMGAFGLVCSAKDQLTGSSVAIKKIMKPFSTPVLSKRTYRELKLLKHIQHENIISLSDVFISPLEDLYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDIWSTGCIFAEMLEGKPLFPGKDHVDQFSIITQLLGTPPDDVIETIASENTLRFVQSLPKRERVPFSQKLRTTDPDALDLLEKMLVFDPRKRIDATQSLSHEYVAPYHDPTDEPEAAEKFDWSFNDADLPVDTWKVMMYSEILDFHQTGEAATSSTGLPEGALAGVDKVETAHASQPVAPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4B5</accession>
    <name>A0AA38L4B5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_387715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4B5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="313" mass="33998" checksum="A618432156277276" modified="2024-01-24" version="1">MSGPPSFSAMSLTKTHHSDTYPAISPTKPSLSQAGKTILITGGASGIGFEIARSFVKASASRIIILSRRTSALDIASEKLRDEFPSSGTEFLTRQADIGDDSSITSVWDSLNSQNILVHVLVLNGVHATPFGPDTLSMDKGELMKGFDVNVGGNFLMSSKFVKQPLRSTDQQLNLVNLSTAGIQRHPAPSQNPYTTSKAAFAALLGRIADERSVEDVQIISFHPGLLCTEGTVSYFGQKLPRWDKMALPADFAVWAASKEASWLHGRFVWAHWDVDELRADKAISTQLEQEKGFLKVAVQGLGGVSFDSYFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4L7</accession>
    <name>A0AA38L4L7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_360211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4L7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041215758" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="21650" checksum="570B3CBE72303413" modified="2024-01-24" version="1">MFSFAVVVVLPLFLQLASAQSCTRNYTVQEGDICDSISAAQNVSTYQLAAVNSGVIDSTCSNLQPGSSLCLGYEGEDCTTTYVVVAQDTCDTISATYGINSTLLYGNNPQIDSACDNIYVEEVLCVASTIAAPPIGSASVNTAIPSTATAAAVATPTTFASSSLATSSVVPSTVVSSTADSFSATSSTVTSVAASSSASSGDDDGDDLPYCDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5F4</accession>
    <name>A0AA38L5F4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_313400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793349">
        <property type="protein sequence ID" value="KAJ3785230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5F4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="615" mass="66900" checksum="3D5D5260415A9B7C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6A1</accession>
    <name>A0AA38L6A1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_386277</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6A1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="450"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="695"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="994"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3786925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116331" checksum="285DE96C5B42E60A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6C6</accession>
    <name>A0AA38L6C6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl transferase/acyl hydrolase/lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_431954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6C6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041443334" evidence="8">
        <location>
            <begin position="22"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="402"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="746"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="791"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="434"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="919" mass="103360" checksum="4062865CC0D43E3D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6G5</accession>
    <name>A0AA38L6G5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_331538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6G5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="355" mass="40678" checksum="2405CD58AD94C2F5" modified="2024-01-24" version="1">MQNALIPDQRPFLARHWNLNDLQRSMAFTDFQFGRFKSTIRDSAPEFGLDLYKVHSRQDPEKWNNFVLWVVENKQKLNDFVEHWPVEAYFNFWIRCKCTHRHRRKEQTGSSIAKHLKIQPPLVRKYVGLKPPPLRCITNSIVQIESRSEVQPVQDSEIQNPCYDEAVRQPCLVCRDTPALVSHSLSKLLQGEVVRKGELVKLGIHSDVDLDTLVLLGPDQVAELFDQASLTNFEKASLRNALKNIRPKFHVKQGATEADIREYIATVYTCQEHSNVQKLQAIPPKLLRLFNKLHIEHLIPAALLLGVTSDTHFEKITTFDDATVEGMICGQTAQIALSPLQKIVLQWALGKRGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6M7</accession>
    <name>A0AA38L6M7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_385445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6M7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="558"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1166" mass="131111" checksum="B5866ECC29FDAC2F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6Q5</accession>
    <name>A0AA38L6Q5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_126018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6Q5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="92" mass="10690" checksum="1327885E8F4B9DEB" modified="2024-01-24" version="1">MSDSESDIDIADLRSKYVLKTVPFDARFPNQNQTRHCFQTYIDYHKCVKAKGEDFAPCQQFLQAYRALCPHSWTEKWDAQREAGTFPASLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB21</accession>
    <name>A0AA38NB21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794040">
        <property type="protein sequence ID" value="KAJ3779941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB21"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="174" mass="19180" checksum="043116CD01EA8557" modified="2024-01-24" version="1">MIHPNIPLFLDQVEMNPAGASMIDRSFLTMDTLGFTQQSSNQPSAKTVRVLSPEPLAMTETQSASAPRTPAHRPFAKGRPTPQAPASHTPTLAPSCDMSDSEHSSSSESIHPVDTYPDSDEEDMRKIEKPLGEVGRPGRGGYNLEAALDWPRSQLERVKRFIKTHVLDTMVRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBL9</accession>
    <name>A0AA38NBL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_411408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793545">
        <property type="protein sequence ID" value="KAJ3781561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBL9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21735" checksum="E828311285CAE5C1" modified="2024-01-24" version="1">MTIQPPWVKRQINFVLIGGTGVGKTAMLELLANIWAGVQPVGFKATHQGLHPAVRPTFLNSAPFPAPMGTRLISSILPDSLTPEGLTWLDSEHKAAIVNAIKKHFETIDAVIILANGTLARLGAATGRALTTISGMFPKSIVNNIAFIFTMVPDPIMFNFDQASLPVELKAKICSIIICLLSGSSTRKGLLRDSCEGFKDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBT2</accession>
    <name>A0AA38NBT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_276501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793509">
        <property type="protein sequence ID" value="KAJ3781981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="51" mass="6010" checksum="A1DAB025CA429BCA" modified="2024-01-24" version="1" fragment="single">GLSAREDRRKCWEARDQYFACLDNVGVAEAWGRDDAYCLFIREQSLRAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCG1</accession>
    <name>A0AA38NCG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF125-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_40468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCG1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="32878" checksum="07AAEE4620590B6E" modified="2024-01-24" version="1">MSAPSNTAALALPRRAKDGLKATKPPIWPIANSITNDSSTPLSSKCDRTSRADGVCCKELKQEERTLIDPDVVRDVIIGLSDGLTVPFALTAGLSSLGTSKLVVLGGVAELIAGAISMGIGGFLASQAERDHFRFLKKQTSARVSVSCSGEMEREVEEILGPLGVDEKACRIVAESLRKAGRESITDSSSAETLRLRWSQDVGLTAFLLKFGEGMEEVPTKRLYISAFTIGMGYLIGGLIPLLPYFFIDNAQVALIYSCVVTGVVLLIFGAIKAQVTGASGGVGGIVWGAVTTLLVGGIAAGAAFGIVRALESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCX3</accession>
    <name>A0AA38NCX3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_250307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="97" mass="10798" checksum="3BDF718F1B89A681" modified="2024-01-24" version="1" fragment="single">NENSLSPEQELTVKMAEANLNDREREIIARRHSSVRILAEDEESREEGPSTGKGKGIDPRNWGNIGIDEEEMNPGLQAQILASLENAQNQSEKNKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NEB9</accession>
    <name>A0AA38NEB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NEB9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="93" mass="9604" checksum="19BA55F28FE49A37" modified="2024-01-24" version="1">MPPASASLVSPPPPPPAVRPRVVSTPVPPSRPAPNGVASTPAAPRRKIPSPPPTAGSHIFPVSEFPPPRPFTSGVRTYPSGRQKGSDFDLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHZ2</accession>
    <name>A0AA38NHZ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-Cys peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_318709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793480">
        <property type="protein sequence ID" value="KAJ3782372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3782372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="238" mass="26637" checksum="9C13EE82B4512DEA" modified="2024-01-24" version="1">MSSVTAPPPDPNRPSLRLGSVAPDFSAETTLGPIKSFHEWLGNSWGILFSHPGDFTPVCTTELGEVARRAKAGDWEKRNIKVIGISANGLEEHYKWVKDINEYGSKSVSETDVQYPIIADADRHISYLYDMLDYQDATNIDPKAGLPFTIRSVYVIDSAKKIRLKLDYPAVAGRNFDEIIRAVDAIQLGDKYKVATPVNWRPGEDVIVHASVQGEEAKRLFPEHTVHYPYLRTTPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIC2</accession>
    <name>A0AA38NIC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_230775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794892">
        <property type="protein sequence ID" value="KAJ3779448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIC2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="148" mass="16155" checksum="0F8F3CAB3109CB27" modified="2024-01-24" version="1" fragment="single">SEALPDIISQFNGAVLDMFPPSGMYSLARNCFVFEEGSSSGISPSGQQTELTIFPEMMGNRKLHIGTLLGEICSQILEFWLIQRLESPIGNEYLNASLLPVLPLLTDMPPSLDSKDTLPPLPSHNSHPEISKSALSKVTPVMKRNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NID1</accession>
    <name>A0AA38NID1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_37824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794742">
        <property type="protein sequence ID" value="KAJ3779508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NID1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="118" mass="13703" checksum="BF9615C959801E33" modified="2024-01-24" version="1">MGNYIRLGKVSGTTLRFRTMFRTKLDLNCVEPKEHLRTALIILQRTSCVWKSTSFDRMQLAMKTFAVDEKSVSGYIYHKLLRHELEPQTLRTTMPKRFSVPGLPELNHSQMFAVKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIY0</accession>
    <name>A0AA38NIY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_231360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793712">
        <property type="protein sequence ID" value="KAJ3780528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIY0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="83" mass="9327" checksum="DE0EF6A36E284F94" modified="2024-01-24" version="1" fragment="single">CHQCLGRDKHNIRQCSRTSLWNGKKNTLCEWNDKGYLQVATGQFAGLELCAEWQRPNGCINQKHTEKHRCSGCASTHHGADGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ50</accession>
    <name>A0AA38NJ50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome recycling factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_430371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793842">
        <property type="protein sequence ID" value="KAJ3780229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ50"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="4">
        <location>
            <begin position="81"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="230" mass="26071" checksum="27D6F9C32B5B6169" modified="2024-01-24" version="1">MSFRHAALRSSSILRQQNYLNAHFTTYAKAGKGAKSTASLVPRSKQPITDPAAQDEYANAERKMTAAVDWLRKECASIETRANGRVTPDLLSSVRVKFPKDDHAFKLEEISTVGVRNASELVITVFEEESLKHVERALYDAKLPGLSSFQKQDNRTLKIPVPKPTVEARQILFATAERQAEDTRVQIRRHHQASLKKGKYEKHSIELEEFQKLTNRFVNNVDTILKGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK89</accession>
    <name>A0AA38NK89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_73942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793458">
        <property type="protein sequence ID" value="KAJ3782718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041278577" evidence="2">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="14257" checksum="CCE3C9C9A85A60B0" modified="2024-01-24" version="1">MCSVFILVVFVFSNTAPVHTCTCLLPFAFFVSALISVCRHGRTLSDHGCFRFGLPGTWVPHTEFVHCGMIFAEELLLLLFPSIFPLIFALISRCDRMSRARYRREITQDNYSLERPRRIWLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKE2</accession>
    <name>A0AA38NKE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_349651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKE2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="351" mass="38031" checksum="2F2FC18AAB8B6B97" modified="2024-01-24" version="1">MPLPLSINVATLQVAGVVSFYMSAALVMVFVNKAVLSSSPDLPLLFLLIQLLIAVVLLHISAAIFRRVEIPKFNWQTARDLTPVVLVNVIGLVFNTLCLRGVEASYFQIARGLQLPLTILVSSIHTSCIPSAKIIVAAALVSFGFFVGVAPSAALPLLASPTSITLFYGILSSLFIALHAVLIKSSLPHCDNSTIQLAWWTNFGSAVFLVPFVVFNGELQILRANLVEGDWNGKVFGWGCLVTGIFGFLLCVAGLLSIKVTSPITHMFSSAARSVLQTLLGFYIFHDILTVNRVSSILIILGGTMFYTWAKSSEFKPSPPQPVDLESARRPSGTLDSKIHTVVWSVDDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLD1</accession>
    <name>A0AA38NLD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_306715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLD1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3788657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="391" mass="44781" checksum="553C1E1D12D18EA2" modified="2024-01-24" version="1">MNLERQHITHLVFLSFLSRTFIYLFAYWSSSSLPLFDASPNLVLISRWSKPLLRWDVFHFAHIAEHGYVYEHEWAFFPGLPLLMSLFKNWDMLLAASMVAIACDTTIVLYRLTLHHFGSSNLAFLTALLSLLSSSPATLRLAPYAEPFFTYFSYRGMLFCAQSKWFFATICFCLANTFRSNGILLSGFILWGLLVDPLIKTTRLPMRLSVYVKSIAYTAMIFAPFIYHQTTGYLAFCTGSDHKHIHTAGPSWCSQSLPLIYSHVQSTYWNVGLLRYWTLAQFPNFIIAAPPFIVMIAYSVHILRKWMRGDASQSEVALIPHTIHACVLCCMLLFNSHVQIVLRLAPSMPLIYWAAAWLVMDHATAARWWVCWSIIWGSLSSLLWSTFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLW0</accession>
    <name>A0AA38NLW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_387504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="446" mass="51192" checksum="C17A2D5485DFC2D7" modified="2024-01-24" version="1">MIIIRNGPLPNDPSREAPERVRKTHKDPETIHRLTKLPIDSKLKMNYEKQLRNANRRERAIGGADNVSDVSSYISIPEEEFEKITKDQPYFDRVKCWLSAHTLSWLADKRKQLRTRTRDSDDTSLIGAIAQPLKRFRANDELNEVDPTNRPFTSFDQAFLDLGLHGYNIPLAFFTNKNIDFLNNNSISFHRTKISHIEGKPQILDLADVTKKMKDSRDAGPVRELDLEHFEWIEATENFYAYQVSLYAEGADAHEPIFYRKHFGFFENQVDSVKLYDLWKDIELEMRQKHQNKRTTFDLFDYRTEWGRVKSRSDALDTATSSTSVSLRSSRFNNTKNQKTKVPVPLVASSAGAWDTRISSTTTLPMDRPSGQPKTDRTFFTRQQEHESAHTGTYFPPARRNAPLPTTYVHSAAVPTQLSNGTPLAESLVPQISNVAAKEPFYPILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLW3</accession>
    <name>A0AA38NLW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_434813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLW3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="670" mass="74527" checksum="51553D8251238ACB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN83</accession>
    <name>A0AA38NN83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_286633</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Also forms a small population of homotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="207"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="235"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3788283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="539" mass="60463" checksum="04796A27CF4AF173" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN90</accession>
    <name>A0AA38NN90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_393382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN90"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="8">
        <location>
            <begin position="185"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="329"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="602" mass="66783" checksum="0ACA6848898D8C2A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNF0</accession>
    <name>A0AA38NNF0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxin/Dysferlin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_345751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNF0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="225"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="465" mass="51971" checksum="BA37921A5200309D" modified="2024-01-24" version="1">MSSSTTTTTSLHEFTNTVPFPLTAVLVRLAPYFTLVKNALEILTWSRSTSYDSWLALAAWWAVCLLSSATLRYFFPIAIILTLTVITASASVRFSAPLFTEINLQTAIADLTVIQNLLPNPHTKSTPSHRPAISTLLRVSAILYPPYLLLTYYVPLQILVAISGTVAITWNSPWASVLRNILHKSAWVRWSAYYVYSKLTGQPLPPRNLSYQTLAASNSVEPGTSLRFLFTIYENQRWWMGLDFSPALLPNERPSWCSVSLQPVSPPNAFALPEPTSVYLRDSNGRQVKRTATWKWEEPEWRVLVRKEDGAVSRVEKPVPVAKEENPSLLMKAAGKMKEVNSAQSSGNAESDNQPFDKDEDETEEEDIVTDADGWVYGDNKWDARSSKGGMGKYTRYRRWTRVAVVNEVVEVVEDGETGIDDPSRGRTSVAMVNATSVSRRTEESPEAESPLRRRLKSALSKGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNP1</accession>
    <name>A0AA38NNP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_336626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793600">
        <property type="protein sequence ID" value="KAJ3781130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNP1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="226" mass="24820" checksum="F16E771092B02918" modified="2024-01-24" version="1" fragment="single">HLTINPTGRLTGKVRPKYQNESTINLIGSHPKKACWVLSNGTYYQLTTQDLSMWAMLLKKHRAVITKPPPPVMENIEKNSGPQAAIKARAQGLAAGDPWSSILPPSLYGWYGAPPPPPYGGYSQYPPPPLCPASPTRAALASSPPSTPSKHAAMPLISEWLVSLDEDAEHGQDKLNFSQFAFTFLEEGIIQVDDLVDLETPERLQKLIMSNWGTANCLLNQECSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNU1</accession>
    <name>A0AA38NNU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VID27 cytoplasmic protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_407583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="225"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="397"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="759" mass="85835" checksum="CF85BA69AA27AC3B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP58</accession>
    <name>A0AA38NP58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CMGC/CLK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_317265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793433">
        <property type="protein sequence ID" value="KAJ3783170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP58"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="200"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="534" mass="59640" checksum="E02E2FB56178F8CA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP79</accession>
    <name>A0AA38NP79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_52009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793417">
        <property type="protein sequence ID" value="KAJ3783485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="23"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="390"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="666" mass="74733" checksum="A560711FC1B08A8E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPC6</accession>
    <name>A0AA38NPC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_376948</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="MU793386">
        <property type="protein sequence ID" value="KAJ3784190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="7"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3784190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="381" mass="40362" checksum="38CA22F1E9B61426" modified="2024-01-24" version="1">MSPRVFRIAVLPGDGIGPEVVAEATKVLQVVNSASPDFELKLEEHQFGGAAIDAVGEPLPPSTLKACQEADAILMGSIGGPKWGVDAKVRPEPGLLTLRKTLGLYANIRPANFASEGLLEYTPLRPEVARGFDTVVVRELIGGLYFGTRKEASAEPDVGTAWDNMIYSEAEIQRITRVAAQIALSTNPPMEIHSIDKANVLACSRLWRKTVTETLTKEYPQIIFDHQLVDSTAMVMVSNPRKLNGVILTENLFGDILSDQSSVIPGSLGLLPSASLAGAPSKVSSPDFKPTHGLYEPIHGSAPDIAGKGIANPIGTILSAAMLLRYSLGLDKPASAIEAAVRKVLDLPATGGYGLRTADLGGKVGTTELGDKVVEALKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPD2</accession>
    <name>A0AA38NPD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_358389</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MU793383">
        <property type="protein sequence ID" value="KAJ3784280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPD2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000092">
        <property type="entry name" value="Serine/threonine-protein kinase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="12"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="285"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3784280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="557" mass="61514" checksum="EA4BF1867C9A1D2F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPS3</accession>
    <name>A0AA38NPS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_351912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="188"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="393" mass="44598" checksum="DDC3187D8968BAB4" modified="2024-01-24" version="1">MSTSSMAVDSHPPAPKLVLDEFIGIALTSSPPELHPFFESFRTLHTRKLWHQLTLKLFEFVDHPLSKPFRVDVFERFVTDFESKMNQLRLVELGVKVSKEIDNPQTHLTFLTSLLTRINKETSPDAYILLYANIAHAKLLYGDLEGTKADMDEAWKILDSVESVENGVNAAYYGVAADYYKAKADYAPYYRNSLLYLACVDPATDMTAEERLGRAHDLGISALLGDTIYNFGELLMHPILDALDGTTYEWIKKLLFTFNEGSIGKFEALAPLLPQEPILQEHYPFLRQKICLMALIESVFKRSADNRTMSFTTIAEETRLPTDEVEHLVMKALSLKLIRGSLDQVDQKAQITWVQPRVLSRQQIGGLAERLESWVNKLNVVEQRIAPEMLTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPZ9</accession>
    <name>A0AA38NPZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_142596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPZ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="371"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3787535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="632" mass="71837" checksum="629C952ED83AA176" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQH8</accession>
    <name>A0AA38NQH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_67158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQH8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="222" mass="25310" checksum="CFC26040A886B671" modified="2024-01-24" version="1">MSLSNYEQLHRQCRTLENLFDTKLTSYSQLVSTISRPLDDVEAEGSRARWKDLEMEAEELLEKLEETNEQLAALDPEMLSSSMLRAIQRHRELFQDNSRELKRTKASVQYALDQANLLSGVRNDIDAYKSSAADSLLAERGRIDSSHRMTDDIINQAYETRADLARQRSSLSGINTRMTNVLNTMPGINNLVSMIKSRRRRDSVILGVVIGVCVILILSYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQZ5</accession>
    <name>A0AA38NQZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_343484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQZ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041252179" evidence="2">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="144" mass="15846" checksum="E82BC96E73E7C092" modified="2024-01-24" version="1">MRLNHIYVLVGLFAVVHTMPVDASGSDPSNITTKKQANLGTSAAPSHLEHSTHSDDGRVTITFLDPAGGIRTVAVGEDSIPKRVVQRVSEHMRSVLPRWPREDGFKFTNDYILSDLEAEFEIKVTADGEAKDHTIPRDPDPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR36</accession>
    <name>A0AA38NR36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_343172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR36"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="147" mass="17210" checksum="B4D7B624B613F374" modified="2024-01-24" version="1">MRLRIIPSYLVILFFGVFVIVRATPVNLPRTEPTLTATMTITYKNGQETLQNKALNDKIQERTVQLLKQEIPKDYHDCKIWEVYKDKVDYRFVNHYDKKPRVINFHADAVYKENGETVKTMTFDKAWMGWGNIHGEIVGNLGNFGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRH1</accession>
    <name>A0AA38NRH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_304310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21845" checksum="0645B025ACFFB57F" modified="2024-01-24" version="1">MLLNVLVAPAQDAVQYEVRYFNASLRTDITNYQGTPTEDIDKNWEDLYRYGIVQIPASEANKLVDKTLPIPGDDENYIVTLEVFHQLHCLNLLRKSLYPDYYSTTLVDHLDHCVDILRQALTCTIDINPLSWHWYEPRQATETKLDGAHKCVDFGKIQDWAYEHKLQTPFDESVNLQLGHDHHEHTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRS9</accession>
    <name>A0AA38NRS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_9566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRS9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="6">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="141" mass="15869" checksum="05B6893EE0524077" modified="2024-01-24" version="1">MISRWVLLSNAKRRISTPTRRVIHTPTPSSLAPPPPPTSTPQTTHYKITLRRSAISLGSRIQDTLVSLGIHRRFQTVYHRHGAEVAGKILKVKELVEVENVEEGMVRTKEEMGRERKARRGYRVVSGGGVGGDGERRRRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSJ5</accession>
    <name>A0AA38NSJ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_282565</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSJ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="179"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3790294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="489" mass="53361" checksum="D72BFBCE6C99F2A5" modified="2024-01-24" version="1">MATGDIGLIGLAVMGQNLILNMNDKGFTVVAYNRTTEKVDRFLANEAKGTKIQGAHSIQELCSKLKTPRKIVLLVKAGQAVDDFIAQLIPHLEKGDIIIDGGNSHYPDSIRRTQELEAKGLLFVGSGVSGGEEGARHGPSLMPGGSPAAWPHIKEIFQKTAAQAYGEPCCDWVGETGAGHYVKMVHNGIEYGDMQLIAEAYDILKRGLGLNEDEIADIFLKWNKGVLDSFLIEITADILKFKDDDGEPVVAKILDQAGQKGTGKWTAIAALDAGSPVTLIGEAVFARTLSALKDERTRASKVIAGPQKEPFRGDKQMFIDDLEQALYASKIISYTQGFMLMRQTAADLGWNLNYAGIASMWRGGCIIKSVFLSDITKAYNKNLKLESLLFDDFFNKAVHKAQPGWRRVIAQAVLWGIPTPAFSTALAFFDGYRSDIVPANLLQAQRDYFGAHTFRVLPGKENAKFKKGEDIHVNWTGRGGSVSASTYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSM0</accession>
    <name>A0AA38NSM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Scavenger mRNA decapping enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_340565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSM0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="321" mass="36440" checksum="D5517ACE623B6172" modified="2024-01-24" version="1">MQDLSLLQSFKLSEILSEEPDRCRLTLLGTLPSSGNTSTSEGHGLRAIIRIEKNAFASEHAASLFKDLIHKAKVVESTDIYTWLSGWTSSQASELKQPHGDVKINVICPATDVHVRKYTKQEIILVQETPELYRRIVEPYIASFPPERTRWVTEILAGRAEQGKVLYSSSAYIILPDMKWDLHTISSLYLVAIARDHTLRSLRDLRGDEHLDLLKSIRQEAYRIVGDKWGIGRGGLRMWIHYQPSYYHFHVHIVNVNYELPGMGMAVGQAHLLEDVIALLAFNSNVYEVMTLTYGLGQQHGLYKPMKTVQGEIDEISPSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSS8</accession>
    <name>A0AA38NSS8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_371294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSS8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041422926" evidence="10">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="25003" checksum="AD4C6002822F15C6" modified="2024-01-24" version="1">MVSNRLSSLLLLLLCSALAANALHFYLDANEKRCFIEELPTDTVVEGHYKALEWSEQQQSYTLDENLGIHVEVEEVETGHTVVKSKGPSDGKFTFTSHDAGDHSICLSTNYTSWFSSTHIRLYLDIVVGTTRPDAEHDRTHVSEIAAKVRDLNQKLEDIRREQQYQREREADYRDLSEMTNTRAVWYSVAQIVVLIVTCVWQLRYLKNFFEDRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT02</accession>
    <name>A0AA38NT02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_383076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT02"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1125" mass="101045" checksum="7CA9983BB31900DB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTR3</accession>
    <name>A0AA38NTR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_257348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTR3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="3"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="207" mass="23616" checksum="DF490898542EFDEB" modified="2024-01-24" version="1">MSRLTLIVAATRTNGIGENGKLPWHLPKEMSYFQRVTCNAPPGQQNAVVMGRNTWESIPEKYRPLKDRLNVVISRRQNYHFGESVQVHRDLASAMEKLRNQTEPAVNRTFLIGGAMLYSACLQLPKTSPIAFVDRVLLTRIIAPSFDRCNAFMPDFLGEWIGAPDFNGWKQASPEEMNEWVGFEVPEGVQEEENGVQYEFQLWVRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTT8</accession>
    <name>A0AA38NTT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_338494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="497" mass="55184" checksum="ED80E469F6450E89" modified="2024-01-24" version="1">MSEYSSSDSDQDLDYWGFTPKKSYFPISNARDTPWTIEQSTQASRNRRERCSLHPVSTRRIVELPVIHQISNGFLRENGRLLYTAKHSSVLRCLEYARTHWHLPVNVPDGILALAALETFLHPFDPVHWLFWSIEQRDQSAKLVQSHIGRRNPTIYHPLSWSILDWKFRLSGIHNKQLPDVLRCKPWYDTLVLSTYLKDLPMRGPVLRKRKVQPPTKTQTNTEQTNDMKQLPAKRSRHTRAQPSHKAALPTDSLSKIEDSSLNIPTLESSVDPARATSVTADISLLSQHHANASESTGRSITRLSRKSPNLPSARATSSTSSSPTPSSTVLLPPSYSRTRSSSRLSARTLVGDIRDLSPSNSSATTAADSSSAKGKQKAVDEPVESEPRLIGVIDVVDEDLASLVNTITDGETDLLFPRLTRSRSGATKTEVASSGPQRSQLGRKNRAKNLHPYLSEKAARGLAPSNPSADDESIGSEALVPSQASRRSRKAKSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYD1</accession>
    <name>A0AA38TYD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_260556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYD1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="104"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1270" mass="140864" checksum="A02D1F76107A763D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYZ6</accession>
    <name>A0AA38TYZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_342043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYZ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18076" checksum="691BD47DFA5F1394" modified="2024-01-24" version="1">MTQIPQEKSRSEERQGLLESEVEGEGEDAQVEQELAEEPTEDPRFHQPTPSPFKRILLLLFIGFLFWFAFVLGRARVLRSKKPQIIYANRYSTEHKYRPAASPIITETLSDGRLRIRGAGPTAIATPTPTPTKTKIKKRKTGKKLGKKAKRAKKFTGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0T2</accession>
    <name>A0AA38U0T2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_339578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0T2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="38536" checksum="2BC6915C898E498D" modified="2024-01-24" version="1">MKIYLKDAIFHGRTFCCCLPVRFGVISMSFLGILFGGLFSILLWFEVSDTSSSMDPHERTAFILAGIVETLLFIASVVGFIGAIVRKQLFITIYTYFTYVHFIINLAVAGFFLYVVLHFSSTAISKACDDTIKDAGAQGQCTDILSDFRTIYIVVALLVLFIELYGALIATRYIHQIKTEKSTARTSRMILLDRAGRSSGGRNSMKPSFDRSGRYSALSEYQGDDISLMPKTNLHNTTPSTAEFNPYEDTEHPRFPSYQAGPSSYVAYNEAPTSEEGYGGGSWTHQQISQDEKTLLRQQEQDDSDVLPRSSSGHGQDRDVKTSAGPPASHEVDPLPQYSPTESSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U6W3</accession>
    <name>A0AA38U6W3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_340897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U6W3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041216719" description="GST N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="271" mass="30014" checksum="76EB095F4AA532D0" modified="2024-01-24" version="1">MSTKPILYVFGASVWSAAAELAAAELFSEGDIEYKTVNLMEGENFAPSFIKKNPNATLPTLEAEGQFYTSTLEVTSYFVKKASTKVKSANPELIEILHADNIDPNTALFLFRDDDEHKAKSELGTGFLGGRQAALEKYSVHPEAEPHKSFYDEKIAANGAFLTLYQGKSSKDEFFAKSHAHFNNIATFFKGPLLSYLPESGFIGGEIPGEDDYHLGAWLTRIAASVGAKNKDDAIPAFEKGFGERVPAKIVSYWKAWTERPSWIKVYPELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7V4</accession>
    <name>A0AA38U7V4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_414073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7V4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="368" mass="40082" checksum="BD597D9572EA7F48" modified="2024-01-24" version="1">MDPIVRIREYQRDRVNFVLENVDLAFANSLRRVMMADLPTIAIDLVEIETNTTVLPDEFIAHRLGMIPLVSTNCDAAMRYTRDCNCLENCAFCSIVLSLNVSCNDTVTMDVTSNHLEMQPHPNEGTEEAGEEQVRRGETFGLPVGKNDLGVDPILICKIRKGQELKLRCIAKKGIAKEHAKWSPCSAVAFEYDPYNKLRHTSYWFETDEKGEWPLGENAREEEPPREDEPFDFNAKPTKFYFDVETDGSLGAQEVVMKGIAELQKKLASLVLALRRVRNGENEMDMPTSGDQTFGDQPAAGSGEEAGWGSGPASSWGNAPSGGGNGTGWGGGGTSGAWGSSPGNANAWSSPSNAGWGSPSAQANGWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K805</accession>
    <name>A0AA38K805_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_122942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793608">
        <property type="protein sequence ID" value="KAJ3781074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K805"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041412848" evidence="2">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="325" mass="34476" checksum="A765069D738C06B8" modified="2024-01-24" version="1">MRSHRTLIPFIALALALAANAAPVLHPLGSHDSHTDLLHLKRTSLPQDLFGTPQFSTEVGSGDEDEQLSRRDFERRAKKKKKKNRQKGKQIQQQAAKAKAESSASNKQTSDGEHVAVPEGNQKEAIKPPQPANKTEGSAPTHAESSNSGSTNTEEKDKAKEEAVSVASHNDPKPGLSRVSTSSSMSSTSSHSSTSSCSSQSSQSSVGSDDPYSHDEMYGSSCEPVPHKPAVEDSGKQDKKTDEDKDEEKKKGKKKWRNGIAGASVVSAAALMTGGVYAMVKMTGSSESAFKSAGGTDGNEGSSSSSESSFDNVQFPGTRKRDINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K875</accession>
    <name>A0AA38K875_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_109735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793560">
        <property type="protein sequence ID" value="KAJ3781419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K875"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041365259" evidence="1">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="148" mass="15885" checksum="E66358D2D00D2130" modified="2024-01-24" version="1">MRASVVFICLFLGFVSTVCTAPLPVRRSDPPKVTISVVDRSDGSDVTIDPTNILSWVQSLLDQQQTALGLPTDFVIVADNVPTKQQRNLQFTIIGGPKCMPTLPCNAVYGTGSGEGGPLFVNVTIRGDEVVWNGDVTQVPYNSARFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8A4</accession>
    <name>A0AA38K8A4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_101634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793542">
        <property type="protein sequence ID" value="KAJ3781599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8A4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="716"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="894" mass="97383" checksum="8C148CB90A102482" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K933</accession>
    <name>A0AA38K933_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_51504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793416">
        <property type="protein sequence ID" value="KAJ3783504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K933"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="99"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="473" mass="50120" checksum="7FAEA1AC48E33DC8" modified="2024-01-24" version="1">MTTKALYPGAPAETRPSLLPKLAIKPWIPGPPPSIRLINALVVDPASGSLLGSNSNQTVLKHTVLMNNGKFVEVRPTVKEDVNPSDKEEVMVVNLKGAYICPGLIDCHVHVTAVAGVKTMSELMRVSAQEVHLRTTYNLKEMLQRGFTTVRDTGGATKVLANAIQEGLIVGPRLFQCGKALSQTGGHGDFAPALSGGHELGCCGGGDVGLFARVADGVPAVLSAVRGELKGGADFIKIMIGGGVASETDAIESVQYTAEEIRAITTTCKQMGGKRSTAHAYTVDSIRHAIENGVQGIEHGNLIDEPTANLMATNGIYLTPTLSCYSIMTRPPFENFLPPSGQAKNEEVMKQGLKALKIASKAGVTICYGSDLLTSMQALQTEEFTVRATTLSSPEILRHATTNAAKMLNKADLLGTIAPEAYADLLILNANPLEDVTVLDRPEEHLIAVIQEGRVVATSDPSGLPEALKGLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB26</accession>
    <name>A0AA38KB26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_370410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794723">
        <property type="protein sequence ID" value="KAJ3779518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34124" checksum="0B82CCAE844B0C14" modified="2024-01-24" version="1" fragment="single">MNVHKPLDLLRKTAFTFPIIDNHAHPLLRSQHRGKVPLETIISEAPSGIGLDRDATHTVACFRAAAQLSEVLGIKRVSGQSDSLWQQVKERRDDLDYEELCDVFMKPCGIQSILLDDGLGGVSEWCEDRKWHKRFGCDTKRIVRIEIEAERLLSPLLQPLLAESDLVDKLEIEMQNQLQSILAEFFHRLEVSLTESARDPEVVSFKSIVCYRGGLNVRPRAEIGIASAQTKRHNYDHVVDSLFQSLLDFKRTGTIRLAHGVINEWIVHWGLRVAGEFDIPVQFHTGLGDSDISLLHASPAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB49</accession>
    <name>A0AA38KB49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_337854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794476">
        <property type="protein sequence ID" value="KAJ3779638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="108"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3779638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="403" mass="45591" checksum="21AD556DE879A62D" modified="2024-01-24" version="1" fragment="single">MGSKTSKIASSDFQEVTSRIPLGDKATGKLQSFSDEQIEDMEKFLVEFDLSFLNSQAYYNEASHEKGEEEEHSLAPSSPPSSNLPHDLDEEVNRLLLNKNFTYSSAQYHLRSRDLHTLNPTGWLNDNVINAYISLLSSTTPPSITIIPSFINSAIRTARTSGMSIRKHEALFRSTKPYPNLMSSRLILMPINIGNTHWMAGAINLPARTLTLYDSSQSLYQIHYEDIFWGIQNWLVNEGKRRQQEMTSLKLIAPQITVPQQLNSYDCGIFTLNFILACAQDKNGFPFDQSDCSYLRRKMCWELAHGKLLMEPLDLTHSHVFKDSSLNVEKEDLSTSSTPVSSVDNEKHPSTELEWSHSAAPPDLHLDLDQEIDELLLREVEDITLKPDGDLNLDPYAKEDLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBT4</accession>
    <name>A0AA38KBT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_139251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793691">
        <property type="protein sequence ID" value="KAJ3780598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="218" mass="23383" checksum="0CF23A4836504AF1" modified="2024-01-24" version="1">MSPHFLCCLPIRLGAFFVGLVEFLISGLVAALMWSGLYLNSQGKISPELSKNQKIAAAIFGASYTILFIASTFGILGVLRKRISWIQSFLSFLRAYLIGNTVVTIVNIVIFFIDNKDTGSCVITDSNGNCDDTSLSRGAQIAIVLVVAVVPLLILAYACWVLSDCVKYLRDKQVYPMTFYPFSNGGYAAVGPNSKEETVSLTHNSGSATGAPYAAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC23</accession>
    <name>A0AA38KC23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_285956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041454574" evidence="3">
        <location>
            <begin position="19"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="360" mass="39832" checksum="E1688BDEF792F2E5" modified="2024-01-24" version="1">MFLPTTLIYLSWSSIVFAGSANFGDSCSVSDNRLQVGTYQFYTDCNSVTYCASNGTCAHRGCRKDDFPFGYPQDSDALPPKCGKGQFCPDEMDVCLNVLPVGSACQMNRDDQCEGPSNYKDLIDTTNRGLNVNGSVCLNNICMWANVTENEDCVVQNTAYIGYTASGGEFIDIVSRGNCLIGLYCDAQSLKCLQEKDLGVSCDADKECSTWNCLSSSVCGIDQALDRHVSSWVYAVVGIGIFIGMFGTLIGLFFLHLKQRDAERERRLQYWREQKAFHQNLSQMREAARTSIMSITRMGNSVRSTFYGGNNSDDSHAPMIQSASSPSRTSGLRNYIGDDGDYEDYDESLIMQQPVDVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDB1</accession>
    <name>A0AA38KDB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_415823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793718">
        <property type="protein sequence ID" value="KAJ3780506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDB1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TEA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="184" mass="20811" checksum="CED8B954A51730FB" modified="2024-01-24" version="1">MTVEQIFVDDLRAYTASTISQSHAVRLISDAAVDCRSRLRNAYLVQYLAQYGIERNRKQVASHLQVLKNMWKAEGNYSTKLVAEMIEILQLVIPVMDRLLAIFKPSIKACKETADSSQVLETQSSGPTPVPIQISTATWKEEPLIAIERRVVAKRSKLQPDTGEQPRKKRKEVKKNEIDVIFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDR5</accession>
    <name>A0AA38KDR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Creatinase aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_39911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793395">
        <property type="protein sequence ID" value="KAJ3783988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDR5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="8">
        <location>
            <begin position="277"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="602"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="9">
        <location>
            <begin position="826"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3783988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="903" mass="101499" checksum="923FB8BDE67CC5FC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEF2</accession>
    <name>A0AA38KEF2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_389661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793459">
        <property type="protein sequence ID" value="KAJ3782696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEF2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="396" mass="44125" checksum="E44A1388E15E7868" modified="2024-01-24" version="1">MAIELVPLPLPASADASKFTDFGREVRGVDPGSLSPELFEQVKDALYKHDALLFRDVRLTPEQQYALTKAFDPESESYGHGNNKTESTKKSILHPDLKTIPRVPQVQLIGNGTVYNHEGLAEAMLKHPSHTTFHKTRVTPEDEAKGITRFYRWHIDAALYDLSPPKVTTLYGLHIPKGSHQICRYDDGTGDELEVPLGTTAFVSGKTMFDILPKELKSLAVRSKVRYAPHPYVWMAPAHAMPTGLGIESEGLELPLSELPHWEEERRKVLPVVWKNPVTGNLHFQVHPCGAAELIVDPLPAGATREGALYPDGAHITELKEVRGLLYKMQRPAIAPNLVYPHDWRENDLVLFHNRGVLHSVVGAFTKEQVRAFHQCNLAASDDPTGPTEEEVKAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFC0</accession>
    <name>A0AA38KFC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Drebrin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_295298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFC0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11819">
        <property type="entry name" value="SH3_Cortactin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="486"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="615"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="71217" checksum="5024E8975204B029" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG25</accession>
    <name>A0AA38KG25_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_313637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793353">
        <property type="protein sequence ID" value="KAJ3785096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG25"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="526" mass="58586" checksum="C63C2ED09D64693E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGC3</accession>
    <name>A0AA38KGC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_354205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGC3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10845">
        <property type="entry name" value="DSRM_RNAse_III_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="72"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="141" mass="15897" checksum="0C71E580FDBACA1F" modified="2024-01-24" version="1">MVIIDRSTKLQCCCCISTVRMNPQDLPPLPRIEDTELFMTVYTHHTSFPPTYHPPASSMTSTSGAPPNLSWLTLSVVNQAAAQKRMRIHYQGTRVGEDHSPTWTVRCFINDQERGVGTGKTQKLAKEEAARKAYIDMGWMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGK5</accession>
    <name>A0AA38KGK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_427652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="181" mass="20202" checksum="8CA550402D8F3209" modified="2024-01-24" version="1">MSLPRSSYDPRRVCINPFPDLHLDKYRRTVGVYIAGALFGIANWAFLDAAVYSAHARVPWGDEPPVHVTFVDWVPGICSLLGYLVVNLIDKDRIKGDEGFGDSRAVWRARLFLFIGFALMAGGLAGSVTVLVLKYALSDYAEMFKYYGYANVSQNILLMLSAVVLWMAQSTSGEYEYNLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGT7</accession>
    <name>A0AA38KGT7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_352112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGT7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005365">
        <property type="term" value="F:myo-inositol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17360">
        <property type="entry name" value="MFS_HMIT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="54"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3786371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="549" mass="60011" checksum="B1ACBBEF2754DA42" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH94</accession>
    <name>A0AA38KH94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_386084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="35507" checksum="F0C9295AAA9F1E17" modified="2024-01-24" version="1">MASIVLKRTNQKMPVVGFGLWKVTKSSCADTVYAAIKSGYRLFDGAGDYGNEKEAGEGVRRALSEGIVKREELFITSKLWNTFHAKEHVNKIAKKQLDLWGLDHFDLFLIHFPIALQYVDPSHRYPPEWWGDDGKTVTLANVPMQETWTCMEELVDQGVAKNIGISNCSGSIICDIFRYARIEPQVLQVEIHPYLTQEPLLKFAKTLGIAVTAYSSFGPQSYLELGMDKGVTALFEHDAITSAASKVGKTTAQVLLRWAIQRGMAVIPKSNSPDRLVQNLQSEDFELSEDDMKAISALNINLRLNDPAEIDPRIAIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHC4</accession>
    <name>A0AA38KHC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Triose-phosphate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_349177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHC4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="58"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="442" mass="49833" checksum="39BC3A89BB4C25DE" modified="2024-01-24" version="1">MARPHQDDRSLDDTLINSMQPREDYYDQEAARSSPYGHILSVDEKRKLWIQNATVNMMFIGSWFFFAILLSMYNKWMFSDSHFNFPYPLFVTSLHMVVQFLLAGLVLNIWPHKFKPERYPTMEEYGKKAFPTGATTSLDIGFSNLSLKTVTLSFYTMVKSSSLIFVLLFAFLFHLERFSWRLVGVILLICSGVLLMVATETHFVLGGFILIISASALGGLRWALTQTLFQSKKMGFSNPASTIFLLSPVMAVTLIILSFFVESWSSLFGSEFFSSGLTRTIQTILLLLAPGLLAFCMVLSEFYIIQRAGMVPMSIAGIAKEVATISISAWFFGDELTPLNITGVAITICGICLFTYHKYLKSIQSTVPLDGHGNPILSEEEAALHSGDDFVELDETSRLAPQSRDDLQIYQIDQSRSQMLFSAEDEEDDERERHPGLSQGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI80</accession>
    <name>A0AA38KI80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar sorting protein Vps24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_284994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24580" checksum="F49668E7BE500092" modified="2024-01-24" version="1">MQTINRFLYGPTPEEKVRAWQAKLRQESRKLDRDMRQLEVETGKARNTVKQLAKKGDVKSARILAREIVSSQRQKDRLSVSKARLGSIEMQLQQQLSMAKFTGALQKSTEIMKLSNSLVKLPQVSQSMREMSMEMTKAGILEEMMDDTLALDDDEELEEEADEEVDKVLFQLTDGKLGQAGTVSTELPSVEQSIEDEEIERNLEKYRQQLNGILSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKC3</accession>
    <name>A0AA38KKC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793962">
        <property type="protein sequence ID" value="KAJ3780044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKC3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="172" mass="19871" checksum="819BE9B9CE545819" modified="2024-01-24" version="1" fragment="single">MSPTHPSDEYSLLAATACRNVDGNPARRLPEFHYRKLYVDCSSDFLLGDELVTLGFIAAINSTETPPLPQEVNSHVGHQNGVRDQDDDSYWKELRDFFESGEFPSRLGTDKARLRFRKRSQRFFLQHNRLWLAPKKSTERLPRKVIEDRSKRPELIASAHNECGHRGRDATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKH2</accession>
    <name>A0AA38KKH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_337334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793835">
        <property type="protein sequence ID" value="KAJ3780239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="677" mass="76155" checksum="150765867AF26838" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLH3</accession>
    <name>A0AA38KLH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_368457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793645">
        <property type="protein sequence ID" value="KAJ3780840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041265757" evidence="7">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3780840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="537" mass="58384" checksum="1A12B4A70BA8F00A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLW9</accession>
    <name>A0AA38KLW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">D-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_366621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793555">
        <property type="protein sequence ID" value="KAJ3781470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="48295" checksum="D0D235CF1E416BF5" modified="2024-01-24" version="1">MTAPTADAISDKSSLNTKHVVVLGAGVIGLTTAISILESASKTNYIVTILASHLPNDPKSIDYTSHWAGAHHVSHATGTGISAPDANSSSTNTEHPEQLAIDQETFRTMWDLSAQGSDAEKCLMRIEQVEYYHEEIPVDKDSGKARHHLSWYPDFKILSSATLSSSPLDLLTQGIRSGVSFNTLTIDTPVYLRYLYQRFVDKGGIVLRGRVDDIRDLKELQRLLHELQPTASDVQIDALINCTGLGSRTLLGVEDDAVYPLRGQTVLLRAPWIKFGRTISSKGKEGKEDLWTYIIPRRSGDIIVGGIKTPNDSFPTPRPETTIDILRRSLRLCPELLHPQPVESAEIRSGTTQLSTDPPSIPNLDQLSDPDLLNLIEPLMVEAGCGLRPARNGGVRLDVEWIESTRRIPIIHNYGHSGSGYQSSWGSATRAWRLLEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM88</accession>
    <name>A0AA38KM88_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_406806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793452">
        <property type="protein sequence ID" value="KAJ3782804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM88"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="387" mass="44422" checksum="C55F3D83CC3E41D2" modified="2024-01-24" version="1" fragment="single">DSYEYTRDSWLNDFDQIRAKDIDAVALNVGRDTWQSARVQDAYSAAAMVGMSVFISFDYTSFDCNIETTVNWVNAYKGLPGQFEINGRPMISSYSGDCLGPDGWQTIRDQTGGFLMPFIYGNDDQQLKKGSSYGFFDSWYCWGCAWPQGNYNKTTDDDHYYMNILESRYATTISPWMFTHYDNKNFYLRGDDWLLITRWEQLISMRDQLTFVEMVTWNDYGESDYFGTGPSSTNSQPSGTTWTDGFPHNGFFDLSAYYITYFKTGVYPRITQDTVYFWLRPHPASINAKNDPLPKPEGWDWTSDTLWAAAFCSSTCNVTLRVGSYSQDFDNLPYGVNKISLPLKALGNVTVKMSMNGQEVINHTPSNFQYQEYTDHYNYNAYVGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM94</accession>
    <name>A0AA38KM94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_234523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794881">
        <property type="protein sequence ID" value="KAJ3779451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="328" mass="37941" checksum="2583982C661BEE57" modified="2024-01-24" version="1" fragment="single">VFLPAISEYIPEEMTKCLSSFLDFCYLARRNDFTTDTITELQNALHSFCEYRKIFLRTKVRAHLSIPRMHSILHYPYLIINFGAPNGVCSSITESRHITAVKKPWRRSNRYNALSQMLLTNQRLDKLTMLRARLVEHGLMPPLQAPAPDPFETDKDDEGAVDADRLLAKVELAKTRARHYPRKLEDLAGYVNQPLLPELTRRFLFGQLSGEVADSIDIDLCPEIHAKINVYHSAIAMFYAPSDNAGIHGMHRERIRCTPSWYGHPRRDTVAVIIDEDEPGFRGMSAARALLFFSFTYKDSEYPCVLVHWYNTYRRSRDNRTSMWTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN31</accession>
    <name>A0AA38KN31_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793785">
        <property type="protein sequence ID" value="KAJ3780336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN31"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="686" mass="76328" checksum="4BFF5AB01D7C2FDF" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNE1</accession>
    <name>A0AA38KNE1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_359047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793391">
        <property type="protein sequence ID" value="KAJ3784079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNE1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="263" mass="29143" checksum="3CAF707ECB559C98" modified="2024-01-24" version="1">MSEIKAIPRLSQDRGHADHGWLKTFHTFSFATFQDFGHERYGALRVINEDRVAAHTGFGTHSHREFEIFSYVVEGELEHKDSMGNTEVLKRGDIQLTSAGMGISHSEKAHGDRPVHFLQIWSLPSPSRLPPKYFTRHFSDAEKQDAWVRVVANVDAEGVQKDLREGSKQGEGPAPVQSPLTMYATLLNQGKSLSQAMKGPKGYVHVVMRSGYNEGAANGATIRVAGQTLREGDGAYLHVPFASDVMIENIGDRVAEVILFDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNF6</accession>
    <name>A0AA38KNF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_35953</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="82" mass="9058" checksum="C4B4C9E3B8371C5A" modified="2024-01-24" version="1">MSTRTGGRQAMSELKLRRLLEHNARLKDDLARPRVRVSEASASLIRYCKTTKDHLVPSVWGPVGKSEDPYGQSSGGKCCSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNP2</accession>
    <name>A0AA38KNP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_368017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793615">
        <property type="protein sequence ID" value="KAJ3781011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNP2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="114" mass="12781" checksum="7BCBB827C47C383B" modified="2024-01-24" version="1">MASAYYEFYRGSSIGMALTDSLDELITSGSITPQLAMKVLQQFDKSLADTMVKQVKNKTTLKGHLHTYRLCDDVWTFIVKDASFKMESNELVNAPKIKIIACKNGEAVENGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNR6</accession>
    <name>A0AA38KNR6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_401546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNR6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="535"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="900" mass="102121" checksum="016DE090563158A5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP85</accession>
    <name>A0AA38KP85_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_356301</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="MU793358">
        <property type="protein sequence ID" value="KAJ3784949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP85"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="120"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="223" mass="24627" checksum="E5C67E4421B0294C" modified="2024-01-24" version="1">MFSLARTALRPSLAKRAARAFAAPSTTASLHTLPDLPYAYNALEPFISEEIMTLHHKKHHQTYVNGLNAAEESYANSPSVKEQIALQAALKFNGGGHINHSLFWKNLAPASGDGGKLTDGPLKVAIERDFGSVDEFKKGFNAKTAAVQGSGWGWLGYNLATKNLEIVTTPNQDPLLSHTPIIGVDIWEHAFYLQYKNVKPDYLNAIWNVINFKEAEKRLVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQB9</accession>
    <name>A0AA38KQB9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_296883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793441">
        <property type="protein sequence ID" value="KAJ3783006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQB9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051012">
        <property type="entry name" value="CellSynth/LPSAsmb/PSIAsmb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45586:SF1">
        <property type="entry name" value="LIPOPOLYSACCHARIDE ASSEMBLY PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45586">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN PA4667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42406" checksum="3881D0452C4F7AAF" modified="2024-01-24" version="1">MGRTKTKKQAASKTTETSTVQSPAVPSITALLEKAQSLIVQCDYELAARFIQRILDQQPSNAEAKEMLGVVQLELGDIDAAKQTFFSLLPPNPDAPSPPPPSAHLYLAQISDEDPRSALQHYQAAVELLSVQLKGKERAGNNAPSDDEIELKSNIVRALIGQVEIWMDPSYDLCFEPEAERTCVELLETALKVDPDNPEALQSLASVRMSQQKPEDAKACLEKSWISWKDLDLDHPRVPPIPARLGLVRLFLELSLYSPALLVLHGVMTADDEEVEAWYLEGWCYFLMAEQAKENAGTLDDLSWEELAKDARDRLETCQLLHTHQQHSDKPLLEHVQELIANLEGMGIKASPPDEGEDESDAGDWVDDDANSEDEAEDVEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQK7</accession>
    <name>A0AA38KQK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_332919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQK7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="296" mass="34738" checksum="E0A8D8EF2D15DAB6" modified="2024-01-24" version="1">MDVEISESTLTQESLKVLTPRLALSWDWNTVSSTVILFYDWILLLPEEIEFIWSAKLLRPFNALYNIQRYMPFIDTVALLYIVSFAEQIDVEKCRVLYNISGWMYIIGITLTEVVLTMRIWALWGKDTRLSIGLPLFFLSCWVPNFYIFHKFLQTETYIPSPLPQIIGCAILGGQPILYLCWVILVVYEAVLLILMLIQYRRQFSLTRVVYRDGITYYIILFLLSIINVATILLLPHDLQNLFTPPQRVIHTILTSRVVLHMRKQSGNQLQYNNDEAYYRQTMLKNTRDAEIKDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRL4</accession>
    <name>A0AA38KRL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_386295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041366639" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18467" checksum="7D8D15C37449094E" modified="2024-01-24" version="1">MTMLTLIAAVTTGLMLAVAASPAVRQTTCTPSFAQDTAYHISSNINDSYVWQFNGASAGILSAVYLIVLPPEFEPWYLTETSTGGWSIAYESPTTDCVIAPADTTLTTGSCSNLSGTAADFAISCSSCSDTTMTACTLTAASTSECVNVPGDSDLNPQIRSLECTGSPEQLWDFTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRX7</accession>
    <name>A0AA38KRX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_416763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36876" checksum="5668544BD60511D9" modified="2024-01-24" version="1">MLPLPVSHPQQKFSYGKIAIRDGNVMNILRSRARITNLGLIILFSFAVFSLLFNVNVWIDASPGLPHSILSTLSEDRTMENLDHLIMVPGHAIWNGASAKNRLDEDLWTLEPYQRHSGRIEAFYQHIVHATKLTLQDENSLVVFSGGQTRRDTTTTEAESYLRLAMQANLLPRDFIRATTENFALDSHQNLLFSIARFHEYTGAYPTRITVVGYEMKRKRFTDLHRVAVRWSKHQFEYIGIDSNDESTVAQEGELRTYSETSQDMYHCHSQLLQKRMNRNYHRRYHPYHVSSPELSDLMEWCPSKASMLYNGILPWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS44</accession>
    <name>A0AA38KS44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_308897</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS44"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="35"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3787545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="388" mass="41921" checksum="34240F78AE64F89B" modified="2024-01-24" version="1">MSSANNIVSNAAGTSETTSSNGHAIIPPTFKSSYKIASIPGDGIGPEVVSATIEVLKVLTKKLDTFELEITDFDWGTDRYLKTGRYTPEDYLEVLKGFDAILFGSVGSPSVPDHISLWGLRLAICQPLQQYANVRPTRILPGTQSPLANCQPGDLDWVIVRENSEGEYAGQGGRSHVGCDHEVATELSIFTRTGVRRIAQFAFSVAQNRPRKMLTYVTKSNAQRNGMVMWDEVIREVAEDYPDVTVDHMLVDAMTVRMVLNPRSLDTILATNLHADILSDLAAALAGSIGIAPTANLDPTRKNPSMFEPIHGSAFDITGLGLANPVATFWTASEMLHWLGESEAAVSLMHAVEKVCAAGVVTRDLGGNAGTKEVTKAVVQEILDPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT42</accession>
    <name>A0AA38KT42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-binding Rossmann fold oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_369960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793915">
        <property type="protein sequence ID" value="KAJ3780102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="3">
        <location>
            <begin position="154"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="376" mass="40704" checksum="79C319A941DED749" modified="2024-01-24" version="1">MSQESKVPIRLGFIGLSTTGWASIALAPPLFEDPISSRYSLVAVSTSKPETAEASAAKYSELASKARGTSITVKPYHGSAKNIVSDKEVDMIAVSVKVLDHKEAAIQAIEAGKDLFIEWPAGRGFEETKELYEAAKNKRIKSLVGFQTRFTAYALKAKQIIESGDLGKILSSTFIISSNGFWGPFTSSLYKYILSSSNGATLLDILGGHALDLFTHILGPISSLSAIIKNQIPYSTLLDSDGKPTGETIPNDTPNQICISGTLANGALFTVHLQASMTEADFNWIIHGDKGVLRIVDDSNRTTKRGFFDASPDVYLNGEKVGIDVDVVTKRTGLNWEAFAVGDTSKFADLEHALKLKEVLQAIRKSSEDGRRIDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTA7</accession>
    <name>A0AA38KTA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_248283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793788">
        <property type="protein sequence ID" value="KAJ3780327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTA7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="184" mass="20354" checksum="849313B5E865E437" modified="2024-01-24" version="1" fragment="single">IVDSRERIIAVLGGVPLGSVGEDWDRVSHEAKEAVEKFRSNSTFTQAQKHGRRGNFACRTVGFGYGNGHAKPLNFGVDGESNRKAVEDFLKNPAIRRIAGFHKSIFNAYAHKMYREYKQTQEDLIRQHPYLCPNFPGTPFAALSINAGPQSYCPPHQDADNAVHGWCIDTALGSFDPDKGGHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTJ0</accession>
    <name>A0AA38KTJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_153575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTJ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="562" mass="63914" checksum="FECF4F51706FB553" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTY7</accession>
    <name>A0AA38KTY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_347795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="36858" checksum="E8E3363FCFF7EF6E" modified="2024-01-24" version="1">MTAIVNGFATNNKISRTLKPGIYAPIPTFFLPESEDLDLPSFEAHVTRVATAGVGPLIAGSMGEAIHLSHAERVILIHAARNALDTAGLNHVPLIVGTGAGSTRETIELTKDAAEAGADYAIVIASGYFAGALAGNKEALKAFWTEISEKSPIPVMIYNYPGASGGIDLDSDIISELALECPNLCGVKLTCGNVGKLTRIADVVSGSEFSSKYPRKNQSAPFLVLGGFTDFITPSTYANGHGAITGLGNVAPYSIVKLLEISVASRQDPSLLPEALHLQGIIGRADFTIAKASISGTKYLLEKLYGYGGLPRKPLPPISTDAAQALWDHPHTQDLVRLERELSGKVKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV51</accession>
    <name>A0AA38KV51_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_429020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793420">
        <property type="protein sequence ID" value="KAJ3783417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV51"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="477" mass="49920" checksum="335F499046F0E69B" modified="2024-01-24" version="1">MTSNGTPHHNAIPSEVGWQFVPQYYNFVNKEPERLHCFYNKRSTFIHGSEGEDGKTCHGQTEIHAQITSLGFQDCKIFINSVDAQSSADGGIIIQVIGEMSNNSDPWRKFVQTFFLAEQPNGYFVLNDIFRFLKEDAVEGDLPDEPEPAAVVSDPLIAPEPVAAPAEHPREPSPPLSPPVEVDATAAPVEEPPVTVAEIAEHEPAPAPAPEPITTQLNGHEAEKPLAPAPVSKSPTPENTLPVALTPPPPAVVAPSSVPTPASSAVAPAPAAPTVRTTWANLAASNTRKWGNAVAHESRGSSENVSSSPAAASTSGAQTPVKSSVTPSRTPHPAYAAAQSLTTAQCFIKSVTDSIGSQALTQALTRFGSLKGPVDIVRNRGCAFAEFTTVDAARRAIIMSLPPAAGGEGGVKVDIGDNETLKIIVETKKERGDRPFNRSRGGPPFAGEGRGAGPSDGRGGGGFRGTSRGSGRGRGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVJ8</accession>
    <name>A0AA38KVJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_435335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793381">
        <property type="protein sequence ID" value="KAJ3784317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVJ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="276" mass="30374" checksum="FE7B16142F8755F5" modified="2024-01-24" version="1">MNAWRWHLSATIQSSLFTGYIYNTDGISSFLPCFALLLVSRGWSTKSCTLFLILHYYLSGINPSKKSPFSLSNRCPTNLSKQYRAMRLDLAYLTLGLASAAYAIPVANIVPSDHTSSPVQAIVARAPRFSTKVHPQYLFPEPFGKATENGMINNPTANAAVETVLKSFGLTDEPEALNDYKLKKLLPDQQIPFLIVSDAELPTTSTSKSPALSCPCEGTVMISIKDGRQIVTGTLTSTRVRESIDELNVDDKTLQALIKEEVLNKKTLVAEFTPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWW0</accession>
    <name>A0AA38KWW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_336683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793610">
        <property type="protein sequence ID" value="KAJ3781058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113103" checksum="CF2B91C27ECF0C4F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWY1</accession>
    <name>A0AA38KWY1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_412856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793592">
        <property type="protein sequence ID" value="KAJ3781178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="39"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="418" mass="46212" checksum="FF9E40294C5B1C41" modified="2024-01-24" version="1">MTGLHFIPSRLDNVEDAQEYQPGGLHPISIGDTFVGGRYRVIHKLGHGGSSTVWMARDHLQDAPKGRVVTLKALRADVSSKAASDIPELIIPRLLAAVLPPSGDLQTIQDHFLVDGPNGTHRILISPFAGLSILAMYDSPGRVSGSRRLRATLARRVARQTATAVCHMHRAGIVHGDLTTSNILFRVADHTETVRTRSGAPVGPHAPAELVAPIENSTLTDSSLLQETVVIIDFGQSYAIADSPSNHQSGTVVHYESPEARFERRAEVEADVWSLGCAIFKIRAGFPLFEPFLGSDVDILRQTVETLGKLPSPWWDSFEERTAWFDDQSGEPKSLEEQERAGSLMKAVRSSIREKLRTVGVDDDLSYGDEGPMMEKCGTRMREEEVELLVDLLEKMLKYRPQERIGVGEVLEHPWFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXM6</accession>
    <name>A0AA38KXM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_275997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793490">
        <property type="protein sequence ID" value="KAJ3782228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXM6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="365" mass="43478" checksum="60E9E541E9C4E846" modified="2024-01-24" version="1" fragment="single">YKSGEDMFQALRKVSQKNHISFHGQYTMPTDPLLSDRERVKMTANEQMYGFCKEYDLHELWAYLWENWYRPLRWRLWARSTVAEITILKTTMICESHWRRIKHDFLHHFHKPRLDLLVWILVTKLAPTYYRKLDIMKKDTGRYRELPSWRKAFKKEWKRCAKTSITLPLNLKYRPDVHRWVCTCPYLAKSRFLLCKHLVQGVEPVPPIFFLQVKRSRIAPVWSHPLLKLLHSQNTDELERLNEEPVVDRIDNIEKSEGEESDDEEEENDDVALNIGSTFKEQMEDLTRDLHSFADGLAYQIQFRDNRMLSAVLRHGGSFLRMMEACLEKEKRHNMNRGAPLATWDSGSASAMYYRTRPRRGEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZE6</accession>
    <name>A0AA38KZE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_395151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="150"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="39273" checksum="7F41A8442CEDFC66" modified="2024-01-24" version="1">MNDGPHEFSRRTSLKWLSAEYHDLNGDYIDILENPPTNLEFARIVQISRPVVIRGFKVPGVSSNKWSNKYLINAMGSRLVSVAVTPNGRADAVTLGPDGKLYFAEPAMERMTIESLLENLSDDMNSDDNGVSLKTYYLQSQNGNVYSSRFFQGLDDPSEFEPLRQDIPSEVKWCTEALDKPPDAVNLWVGDGSSVSSIHSDPYENIYTVVRGQKHFTLLPPTDGWCLDERFYPHATYVRTPDQGGSMTLQPSPGNTPPVRWSSILNPHLPGRLPPEAHPIHISISEGEAIYIPVGWWHHVRQSGITVALNWWYDTEMRGMSWVMLSYLRAMKDVTSGNSNDEKSDVMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZJ1</accession>
    <name>A0AA38KZJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_427830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041217140" evidence="5">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="136"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="435" mass="48029" checksum="16CDC478D8B82E56" modified="2024-01-24" version="1" fragment="single">MEVALAFSVIFCAATLIPLVHCYSNEPREYTNTIPISRRSLLNRRTLAGDFDAVFARDEQQAVYQKYLTMAPEILAGIFPAPENDMEKFVQSKYVNEVSPDTDNVMEQVVGPVDVSNVLLTMSMTDVIVNEVDMLYYGDLAIGTPGQGLTFDIDTGSADLWVPSPWCSTCTKNHYDGSQSSTYVDKGRRFAVSYGSGTVYGTTASDTVAIAGTAVQNQTFGVVYRESEDFQEYPNDGILGMAFGTIAQSRGLTVFETMMKQGKLKWPCFSVHLARSQETGSEMCWGCYDPTKATGPISWFPVSHRAYWSIPMSAFDVAGQRTTFDEAIDTGTTFCYFPASIAADIYAQASFYTYPCASKVDLRFVFGDVAFLLHPDDFNLAINYSECMGGIFAMDATEWPSNLAIIGDEFLKSWYSVYDYSDGGRVGFAPSVNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZX4</accession>
    <name>A0AA38KZX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_168837</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZX4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3786578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="391" mass="42116" checksum="9C1F2F4F0FC780F5" modified="2024-01-24" version="1">MSSSSEKVQTRSQRSKWIIIGSVIGLLGLIAIGVGVGVGVSKNNSKNSSKTSSDTANGATSNSSSNGNPVQSDPNDPSTFEKDPNLHQSFYALAYTPAGSQLPNCTNSLEDVIEDIQVMSQLTKTVRLYGADCNQSALVLEAIKQTKVDMQVYLANYPTPDDSTAYTRQRDEIKAAIQTYGTDHIAGVTVGNEFMLNYLDANGATDPNSAIGAQGAAILIADINDTRSTLSEMNLSKTLPVGNSDAGSYFNTQVLEAVDYGMANVHPWFANVTVQTAAAWTAEFFEETNVQPAALLPNTPKMYIAETGWPSFSSDAGNANNGASDASEANLQIFLDTFVCQANQNGTGYFFFEFKDEPWKDAEFGGVEGWWGLFHSNRTLKRIQLPNCVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0H4</accession>
    <name>A0AA38L0H4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_263449</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="15">
        <location>
            <begin position="984"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="1648"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="16">
        <location>
            <begin position="1975"/>
            <end position="2007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3788198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2007" mass="225456" checksum="47C8F6881DB3F4E1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1N2</accession>
    <name>A0AA38L1N2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793899">
        <property type="protein sequence ID" value="KAJ3780127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1N2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="122" mass="13424" checksum="8AAE29B500EC9CCD" modified="2024-01-24" version="1">MGLQSQSQMDLDKPDESDKSSSSLKEDGEFSDPESKSMEPMDPDKADVTQQRVIMLYVCGSQSNVRNPMLLLPLTLDTQHVGGTTNSSVEAQLPFLLLLGLCFQGGDEMAEVAHEWSEGFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2H4</accession>
    <name>A0AA38L2H4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793927">
        <property type="protein sequence ID" value="KAJ3780085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2H4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="203" mass="22902" checksum="8F958A0EC3A2C977" modified="2024-01-24" version="1">MSTRNNANTGKETTSAQEEDHGDFQTLIEKAITWKLMAKNDNCAVVLPNRLLRLATSAKESGRSKTAVNDTLDKIILIAQILQEWSWKDKSDEWRKELMEHMEEELTTRTNNICITIDGIGREARTTWKKLEEMTEKMTEVSTKIATIGNTIPDRDAQTGREEGEIENGPPKSSQRSRNKGQTDRHHLPDTIGLDPGRERAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L364</accession>
    <name>A0AA38L364_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 63 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_120584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793593">
        <property type="protein sequence ID" value="KAJ3781165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L364"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="582"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="2">
        <location>
            <begin position="859"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1097" mass="126087" checksum="64DCF5BD901DBEBF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3M5</accession>
    <name>A0AA38L3M5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_41744</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3M5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="198"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3783862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="423" mass="46919" checksum="AEB7F44DDEFAF65E" modified="2024-01-24" version="1">MPSLRGTTFDSKSPSVPGGIKAYYQTKIEAAELTINQKTQNLRRLEAQRNALNARVRLLREELQLLHEPGSYVGEVVKVMGKNKVLVKVQPEGKYSKCTTLTYLVAITPSAVVDLDSEIDINALTPNLRIALRSDSYTIHKILPNKIDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRGESGSGGGDSEVQRTMLELLNQLDGFESTKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPGPEARVSILRIHSRKMSLQRGINLRALAEKMGQCSGAEVRGICTEAGMYALRERRQHVTQEDFEFAVAKVMKKNQEGNTSVNKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3N3</accession>
    <name>A0AA38L3N3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_435614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3N3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="240" mass="26919" checksum="4D0D398B95C85F8C" modified="2024-01-24" version="1">MTPWARIFYSPASRRTSSYFSSKAGGGRYFNSAKPLSAPTAPKKASGGERAESVSNDTTGQALKTAEESPSVYRETITRLAVPEFVPSTHPVISDRDFKLHQFFSLHRPLLLLSNPPSILHSSLPTSMLSLPKLPAAPALPTTEASLEFAAASDAEAARTLARALAINRAGSTFVWEETLKRIGLDVNLEPERIGLRERLDKELQEVRLDSTRRKRRKKMKKHKLKKRRRLTRSQRLKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4B0</accession>
    <name>A0AA38L4B0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 12 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_296589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793433">
        <property type="protein sequence ID" value="KAJ3783175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4B0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="9201" checksum="C1A6B2D7615ABF09" modified="2024-01-24" version="1">MAIDEEQRAAIKAKLQARDEHVRESWVRAMEARLVREELEKCQRTEGVNSFENCKWLSTKLLEKLNDSRVKGYKHVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4M3</accession>
    <name>A0AA38L4M3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septin ring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_190967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4M3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="27"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="312" mass="35579" checksum="02B35330FCC8080B" modified="2024-01-24" version="1">MAEEIIANSYVGFDTITQQIEHKLLKRGFQFNVIVVGQTGLGKSTLINTIFASHLMDSKGRFAAEEPVRQTTEIQTVSHIIVENGVKLRLNIVDTPGYGDQVNNEGCWDPIIKYIKDQHSAYLRKELTAQRDRYIQDTRIHCCIYFINPTGHSLRPIDVIVMKKLSEVVNVVPVIAKSDTLTVDERLAFKDKIREELVYHNIRLYPFDTDEDDEEEVNLNATIRSIVPFAIVGSENNVIINGAPVRGRKNRWGVVNVEDPNHCEFVNLRNFLTRTHLQDLIETTAQIHYEAFRSKQLLALKEGVNQRPPTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5B3</accession>
    <name>A0AA38L5B3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orn/DAP/Arg decarboxylase 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_386147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5B3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041308961" description="Orn/DAP/Arg decarboxylase 2 N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="6">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="224" mass="24327" checksum="0D802B9E33DD6B34" modified="2024-01-24" version="1">MASLTVAYVLCLLAASGAGFDCASNGEISPVLNTGRIDPSRIIFANPCKANSFQYGASMLRLLMIWDELYEVARTHPRAKLVFRILNGRHEKFVSIGPGIWRSACYGFHVGSGCYDPLVHSGAIIRARFAFDIAKDAGFSFNLLDVGGVLKIHHSNKASDSRTWEVIGVQGLECLAAIIIARRAPFSDPEVSTRIDQPSVVCCVYPYVLSMNGSIHNSSSEPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5K9</accession>
    <name>A0AA38L5K9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BRCA1-associated protein 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_348594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5K9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="278"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="455"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="601" mass="66672" checksum="3FC133D7AC53C243" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5P0</accession>
    <name>A0AA38L5P0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_354079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5P0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="38769" checksum="35CADEEF5BE693A9" modified="2024-01-24" version="1">MKVTVKTTSQKVFNIDAEATESIGDIKAKIEQYQGFAASSLKVIYSGKILTDDKTLESCGFKEKDFLVVMVAKPKPTSTPVSFIDATTIIRASPPPDPAPAPAAPSTETIAEPAPTTSTAPVETPAAGSSFLSGSALQTSIQSMVDMGFERDQVMRALRASFNNPERAVEYLMTGIPAHLEAEADGSAATAPRTPATAAPATPSAAAATAPAPAPTSSSNQPQNLFQLAQQQQQQGTGRGAGAAAGAGAGGGPQLDLAALASSPQMQQLRQHLASNPEAIQPLVQSIAAQNPGLAQLLAANPDALMNLLGGDLEGDEGDLPPGAQVVNVTEEERAAIERLEALGFPRQAAIEAYFACDKNEDLAANYLFDMGNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6H4</accession>
    <name>A0AA38L6H4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial F1-F0 ATP synthase subunit F of fungi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_143701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6H4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="97" mass="10170" checksum="FFA088F93925B66A" modified="2024-01-24" version="1">MRASLIRRQLGGLVPPKIATPKSVSGGSGDGLGPLVNFYSKLPKGAATARISGIKGRFFNGANASGLPLLALIGGLFGIGYTIDYHMHLKHHKNHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L759</accession>
    <name>A0AA38L759_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_82804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L759"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="366" mass="42111" checksum="12893483B120B031" modified="2024-01-24" version="1">MSSRKASSKPLPKFEIGEDYQLLHAIGEGAYGTVAAALHKPSGRQVAIKKILPFDHILFSLRTLRELKLLKYFTETSINENIITILDIIKPPSFDEFTEIYFIQELMQTDLHRVIRTQHLTEDHCQYFVYQTLRALKSIHSADIVHRDLKPANLLLNANCDLKVCDFGLARSIETTAGKEPGVMTEYVATRWYRAPEIMLSFRMYSKSVDIWAVGCILAELISGRPLFPGRDYSHQLDLVLDVIGTPSLDEFYAITSRRSREYIRSLPIRKRRSFAALFPHASSEAVDFLSRTLAFDPKKRMTVDECLDHPYLRQYHDPEDEPSASPLSPTYFEFDQHKDKLSKDQLKELLYEEVISFKSTINDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBI1</accession>
    <name>A0AA38NBI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_367722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793600">
        <property type="protein sequence ID" value="KAJ3781126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="400" mass="43698" checksum="BBCC73AA107F0CAB" modified="2024-01-24" version="1">MSLPTIINKRAPGVPFYTPLQNPPAGSARSKPKTLLFTPLKIRGVEFPNRVWVSPMQQYSADNGKMTPWHMAYLGGILIRGPGLTFVEGSAVQAIGRITPEDLGLWDDSQIASHQEVVRFAHSQGQKIGIQLMHSGRKGSCVALWLSFSAVATPAAGGWPDKIVAPSAVPFEPGYPVPHALTIKEIEDIVVAFKDSAQRAVTAGYDVINIHAAHGYLLSEFLSPVANKRTDKYGGSFENRIRIVLEIIDAVRAVIPDTMPLVLRVSATDCLEHENYPSWKLPDTIELAKIIPKHGVDVLDVSSGGQSAAQTINVFNIQSVYAKQIKDVVGDSLFVGCLGGITSGKVAEQYLQEKRGDMCFVGRNFLEKPGTAWEFAEELDESVHMSKQIEWPFIGRGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCQ2</accession>
    <name>A0AA38NCQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_314458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU793366">
        <property type="protein sequence ID" value="KAJ3784726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCQ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041490800" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="30"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="524" mass="56726" checksum="E0E2E36B068DBFB0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND06</accession>
    <name>A0AA38ND06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_354268</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND06"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="70"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3785626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="413" mass="46026" checksum="06BEF44F539E130B" modified="2024-01-24" version="1">MFTNRCSSTGAFSGASALSRRSFTRTPSRSLAALVNGFKPLDEPLHLSVDDGYGFARIKAGDILGQQDRFSVIRRLGWGMYSSTWLAKDHQDEKHVAVKVLTGFASRLAHEGLTPELDVLRKLSSSPHGAEPKEGHCLSLHDNFIHPGRTDTGPHLCLVTDVFGGDVEHLKRIYARNGFPLSLAKRILFHTLKGLETMHQQGIVHTDLKHDNILFDGGNADLGSADPLPVPSINEALDRTFVIADFGNAQFVGKPTFDEITAEALRAPETLLRGPWDEKVDIWTFGCLAFEFLCGRQLFKKRSYSEHLLDAVGGHLWRMQCFTDERFDSDQLKNSELGYTYFDSSCQLKSRPPQFSHTVSKILANFNILDSEQLSTTASFLHRCLRLDPRNRASAEELLDDPFWEGVHGAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND44</accession>
    <name>A0AA38ND44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Voltage-gated potassium channel beta-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_311928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3786001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND44"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="368" mass="41381" checksum="B55D64ADD65C77CB" modified="2024-01-24" version="1">MPPQLQQDVKVEYDPKGMPFRRLGPSGLRVPLFSLGGWLTLGGSVKGDPVKEIMKTAFENGINMFDTAETYANGKSEEEMGRVIKELGWRRTDIIVTTKIFWGVGRKSPNDGGLSRKHIIEGTQESLARLQLDYVDIIFAHRSDPNVPMEEVVRGFNFVIEKGWAMYWGTSEWSAVEIEEAHHIATKLGLIAPVVDQCQHNMFTRERPEKEFAPLYQQYNYGTTTFSSLYFGLLTGKYNDGIPPGSRFATEGDFINMSKELQEEKGKEMIRKVRELTDIAEKELHTTISALALAWVARYPNTSTVILGASKPEQIVENLKAIEVVPKLTDELLERIDKILGNKPDAPPSYGRPPLDPFGQYGSKAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDB0</accession>
    <name>A0AA38NDB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_351380</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDB0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3786541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="396" mass="44661" checksum="8331D9B82AB481CD" modified="2024-01-24" version="1">MSGINAGDEKLVFESSEAVSVVSTFDDLGLKEDLVRGIYAYNFEKPSAIQQRAILPITQGRDVIAQAQSGTGKTATFSISILQSIDVTVRETQALVLSPTRELATQIQSVVLALGDYMNVQCHACIGGTSIGEDIRKLEYGQHVVSGTPGRVFDMIRRRSLRTRNIKMLVLDEADELLNKGFKEQIYDVYRYLPPATQVVVLSATLPYDVLEMTTKFMTDPIRILVKRDELTLEGIKQFFVAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTEKMRASNFTVSSMHGEMPQKERDAIMAEFRGGTSRVLITTDVWARGIDVQQVSLVINYDLPANRENYIHRIGRSGRFGRKGVAINFVTVDDVRILRDIEMFYSTQIDEMPVNAAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHQ2</accession>
    <name>A0AA38NHQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_106910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793550">
        <property type="protein sequence ID" value="KAJ3781517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHQ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="4">
        <location>
            <begin position="290"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="387" mass="42906" checksum="8B3D899D6CD30808" modified="2024-01-24" version="1">MASRPTVNVRSASGGKIMPCYFRALLIMALTEASSSLPLPAVLTAPIRLDVVSQVHKSLAKNKRQAYAVSEKAGHQTSAESWGTGRAVARIPRVGGGGTHRSGQAAFGNMCRGGRMFAPTKTWRKWHVKVNQNQRRFATVSALAASALPSLVLARGHRIEQIEEVPLVITSEAESFKKTKEAVALLKGLHAYQDIVKVSNSRKLRAGKGKMRNRRHRQRRGPLIVYNEDNGIVQAFRNLPGVEVVNVRRLNLLQLAPGGHLGRFVIWTEGAFGLLDEVFGTFDKASVYKKDYVLPTAKIFNPDVTRLINSTEIQSIVRPAGQKTQKRPWTQKKNPLRNKAVLFRLNPYAKTIRRHELLKQERLKKKPVKKAKASAAGEAFLSTLHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI88</accession>
    <name>A0AA38NI88_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_361384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793427">
        <property type="protein sequence ID" value="KAJ3783287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI88"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="211" mass="22189" checksum="615A06E7A4837A96" modified="2024-01-24" version="1">MDIFQRMEQFWILTFFANVVSLALIVGNANGRYKSMKSTVGLSILAVFATAALGNIIPRDFAALQNDVQIVTKNCFALKNTIEQVKAPLSSTILLNLIAGSNNLSAALNVFASDAEIAGVITSAQALTLLASIGESIDDCIIPALNELTADAALLIVFKPEIEANLKKLQISYLSCANNLISACPSAQKAEASQVAAKPNAALAASLKAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ89</accession>
    <name>A0AA38NJ89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_249719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793605">
        <property type="protein sequence ID" value="KAJ3781098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="58" mass="6916" checksum="3223C76CCAAD2CA8" modified="2024-01-24" version="1" fragment="single">RSFLRHPVVKSYLSSRFPMLQNPMLSDLHISLSNCSHLKVYIQRIKRTCFPWRIGWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ92</accession>
    <name>A0AA38NJ92_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793602">
        <property type="protein sequence ID" value="KAJ3781113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ92"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="376" mass="42169" checksum="744493B4BD568E74" modified="2024-01-24" version="1">MASFAVARHCLFRFPRHEGIIRRSIHSSPITWKKKASKLEIEDLFSNEPVEDLLSSDGNPPAPARVEGSSNLKPKQSVPSKHLDLATRHTHFEELYKRVLMQTSSNPKERRKLPPLRNSVWIRLVDLAQNEEELGKVIALVPKWKDMTRHQLGKGGLEEQWGELVVSRAESLSCATLALGMFSNHAKYQVPLSLPAARHLLHALHTQSSLEDVMTAVALYRVYNLTPIAHDLISLGLVCRALVGRIYQPTLAVQTSPSAAPQKGNIQASKEVLDALIQSLRDLVSNTDPSSFYISPHARTRALTPKFSERQKYAEKGFAAMEKEKTWLKWCLKKIEVNLGKSEGFEKIAWLRQWREAAGHVNANHSSPSLTATTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJA9</accession>
    <name>A0AA38NJA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_390806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793589">
        <property type="protein sequence ID" value="KAJ3781203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJA9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="525" mass="59160" checksum="0AC0D451CBAF89D8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJQ8</accession>
    <name>A0AA38NJQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_390750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793581">
        <property type="protein sequence ID" value="KAJ3781264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="255" mass="27696" checksum="D3CA2A8E1AB535A2" modified="2024-01-24" version="1">MPSRQQSPTTASTGSSTKKAGHQRNPMACTNCRARKIKCDSNKRYPDHPCQRCVNRKLVCEYVAIAHAPPNDTRSRSGSFSSAVYPSPLLHDSNGKPHAATNSPHMQARYSPLSTSLHSRSSSRSDPYVHSFDAAQYPSSNSSYSDSSSGMDSHLSSPLYGFYGPSENFGDSMMHGGSQMGHMPNIAMSSTPQYGNFSSGMPGMVLNSLPDQNHYFNRDPSYADWNTAPNASQGHYGAGNAVHMRKSQVLLIPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKI5</accession>
    <name>A0AA38NKI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_317359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKI5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="82928" checksum="17DFA4ACB325B325" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKP8</accession>
    <name>A0AA38NKP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_433006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKP8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="290" mass="32301" checksum="7F8C9732B4C6266C" modified="2024-01-24" version="1">MTTENYNNSNSSSFKLGSTILGELFGGAVPTCALFGLYICALAISIYTCAENGIHGRPQKILWACMTLLSICNVWHYGIQIKFVLLAASSLSDHHIQVEKPLTQVCTVPLNINLVVGDAIVAWRTCNIWTKHIILRYLLAMLMAGNIVANIVDVVIDAVTDAATREITMDYVATSFSFAVNLLCTSLIFVKAWSYFQNFRVRPLDAGQSHSYTDIKRILTLLIESGIIFCSIQLISILVQIFTYHQETYALRIWNLALGMTRNAAAPTLLVRWPSGLRRQTKETNAFDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL89</accession>
    <name>A0AA38NL89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_345973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23485" checksum="01DD28E020936129" modified="2024-01-24" version="1">MSKPTFFRNLWRRVWNPTGFVGKDLEGNSYYERSNPLRNAGYSRSKRSVTYRNQDDMWNYIGGSKRLPIQWSAWLAHTRTNPPSVQELQMDLIRQHRVQHNAALIEASFQQERAQLRLQDGASSGTSSTSSEFQPSQIQDPLSNSTANSASSSSPSLAPKVSPAPPSESKAIPNPEPSPGAHRPATSLPKTGSDEWQPESWAPKLRIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLJ1</accession>
    <name>A0AA38NLJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_356954</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="10">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="13">
        <location>
            <begin position="284"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="12">
        <location>
            <begin position="449"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3784728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="613" mass="68912" checksum="44F066321A8C5675" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLQ0</accession>
    <name>A0AA38NLQ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_388176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLQ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29420" checksum="DDF75AF2E564F858" modified="2024-01-24" version="1">MNVLAIGASRNIGYYASLRLLAAGCNVVFMLRSPSIFDSDKAIQPYVQSGKAHLLKGDALVQSDVKHAWEEALTYGAVDLVLFSVGGTPSFSVTKGFVISPANLVTHSLMNVLCTISTQSPQPKLVTISSAGLTPSSHAKIPLLLKPIYLLLDIPHKDKLGAERAISHIAGWPWPESNGEPESDIMGERWMEKEGLPAAGTFKNVLVIRPALLTDGECKADKAREGKVGYRVKDGDFVAWSVSRKDVAHFVADAVLNRWTEFQNKCVSIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLT5</accession>
    <name>A0AA38NLT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_387642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793349">
        <property type="protein sequence ID" value="KAJ3785208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="3">
        <location>
            <begin position="194"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="535" mass="57786" checksum="208DC550BD4FCFB2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM07</accession>
    <name>A0AA38NM07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_4745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="223" mass="23568" checksum="FA465ABCED1FDC7D" modified="2024-01-24" version="1">MSNNKSPLTDGSVRRSSPIPIANPVMNRRGRSASVSSGSSSSMSPASELPTPLSGFSPRITVPSPGSSPILSYFLAQSPTKTQTSATLPFRKFGPAPVFENEEQPISPAAHHARRASLTVADRFNQPNSTAVLPDYHVERGAGLLRRLSLSTGAPAFGKPFPSASQSPPDAPPNTAVSPTAPTLPYPRDAKHRRATTASSARPHRAPSPMGERILKGHFDGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNA9</accession>
    <name>A0AA38NNA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sec7 guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_262902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="754"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="614"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1840" mass="204559" checksum="CF7EA1C6788361FB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNY7</accession>
    <name>A0AA38NNY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_364631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793499">
        <property type="protein sequence ID" value="KAJ3782105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="170" mass="20200" checksum="0436F5FF05351C22" modified="2024-01-24" version="1">MGLQEFQIVGRHLPTESEPTPKIYRMRIFAPNEVVAKSRFWYFLRQLKKVKKANGEIIGVNVIHEKKPLKVKNFGVWLRYDSRSGTHNMYKEYRELTRADAVKSVYQDMAARHRARFRSIHILRVVEIEKSEDVRRPYIKQLLVPKLRFPLPHRVSKTKSLFVAHRPSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPI4</accession>
    <name>A0AA38NPI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPI4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041222200" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="79" mass="8293" checksum="90A22E01BAFBBCF0" modified="2024-01-24" version="1">MKLSLQVVFLALAAVGANAAFGRKRDTADSVVAETTTATTAPLTLTATKVFHSLISESPYMTAVTTEVVWTQYPVSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPL6</accession>
    <name>A0AA38NPL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_434487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793339">
        <property type="protein sequence ID" value="KAJ3785540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF199">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="109"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="373" mass="41984" checksum="B3973F8931CC008B" modified="2024-01-24" version="1">MLYRERRSWTEEEDQLLRDAVELEEPGSINPSKWHAIAKHVPSRTNKDCRKRWFAKMASDVVKGGWAPEEDEKLVQAIEKYGTRWSLVSAFVQTRNSDQCAKRWTDTLNPMIDRTRWSPEADTLLLDAVKEHGKLWTKIVRIYFPGRTGLAAKNRYNSITRFSSRAPRRKSYKTRYESESASSTISNSPSMSSSTSDTSEPPNTPPSFELSTPLISEPLHPEIAPSESMLDPATWSPIEISACTSQSTAFTYEDLCNVMVSSSDILNGVTGLSDYHGFQSPQAQSSIIPWETMDETYSEIQHHSLSPLALSPISDPCSVHMNTSTATSIQADGEILGNSLHIHRNEYGYATVPFWESTSSDPHSFLTQWTSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQC0</accession>
    <name>A0AA38NQC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_71228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQC0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041465019" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13151" checksum="86338C5554898381" modified="2024-01-24" version="1">MHFRPQFKLLVFHFLQSLFGIVPDSSTSSYLPPTALSRATWFLSFVFCFTNHGDRCGIPVLWWVYIHIYSSVRIHYRQFLPLLVSRVPPKRKEEKTNKVPPLSFSAGKSLSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQT7</accession>
    <name>A0AA38NQT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_54882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQT7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="96" mass="11065" checksum="F5F07226A0D16E2C" modified="2024-01-24" version="1">MSNQPSRRAILSLYHSTLRTSKSFSSYNFRNYFIRRSKDTFRVIQSESDPARVKSLYAEATRELAALRRSAIVNQLYGGSRLAVEDQKPEMTRADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQW8</accession>
    <name>A0AA38NQW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_404119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041422424" description="DUF1793-domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="338"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="74512" checksum="A7E776AFD7C1DEAA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR94</accession>
    <name>A0AA38NR94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_343003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="348" mass="38892" checksum="79649F2C859C9D7D" modified="2024-01-24" version="1">MSSSTGKMTYSRLGNSGLKVSRIILGTMQYGSPEWQPWVLGDEDEAIKHIKTAYDAGIQTFDTADVYSNGLSEVILGKAIKRLDLPRDEIVVMTKCFGVVGKTPGENLIATRADPDANGYVNQHGLSRKHIFAAVKNSLERLQLEFIDVLQCHRFDPDTPIPEVMQALHDVVQAGHVRYIGMSSCWAWQFHAMQSYAINNRLTPFISMQNHYNLIYREEEKEMFPTLKYFGVGAIPWSPLARGLLTRPLDVQTTRGSTDWFIGRYTAAIGTEEIIKRIEQIAQKKNISMAQVAVAWSLAKEGVTASIVGTTSLRNLEDTIAGIHVVLDAEEMKFLEEPYKPTAVIGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRD3</accession>
    <name>A0AA38NRD3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_342571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRD3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="187" mass="21183" checksum="934FD802AA33AD06" modified="2024-01-24" version="1">MSNERNAAIDAHYDAVTHYICNVGFSGTEKVSMDPVDAWQASSVSLKTTLDLCTLAVELAESTLDESRKEVLIHSKIMDQKTKNRYWRQPQAESEDTILSCWESDPGFSFHGYGLEQDLVLANPGNKVIGSFGIPDQEHDTVVPKLPSVDMQDLYPRANGLYEKLENEKLRKMVDNIKVWRERCFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRH6</accession>
    <name>A0AA38NRH6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Afadin and alpha-actinin-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_383818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRH6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="721"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="140"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="885" mass="96637" checksum="62CE0AF7FB303EF5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRL9</accession>
    <name>A0AA38NRL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_16440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRL9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="16222" checksum="871DA0C6D6980DEC" modified="2024-01-24" version="1">MSEDALNSLVEQRIAQLAEISEKRNALLREMYRMMRKRTNVRATVSIDDEEEDDLHVFLKNHDLQEKHGIYQSFIRKRALRSCFSRRIYIPPIGLSSVAIYISRTCRWSSPKQISFLWKKLYGKHSDNPSGVRSGRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS48</accession>
    <name>A0AA38NS48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_392285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS48"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="49311" checksum="83604476153CE07C" modified="2024-01-24" version="1">MSQRLVHLVYIHGFRGDETTFQTFPTHVQQYLTTHIPSHLNIKVQSSLYPTYKSIKPISSATKNFIEWLQTQPPGPVILLAHSMGGLLAAEAANDPSTTNDVHRRIVGLIAFDCPYLGMHPHVVVTGIASLFPKKTDDKMKTEAELNPSPDVRIVDRTKETENWEDKQDMPSPSHSSTSLPAKNEHFPKSDSLINRTMKFISSHSDDPLVRWTRKHSDEPFSAGKRWVMEHFQFGSCMFDPSGLRDRYVNLVSPKGLFWVNYWTITTPKEKRNASHNSEDLDRQQLLDDNNQALIRTGIANPSDKPSSSFDMGQLVSESSTLSLENAHEESALLDPQSDVHAKNKPRVQQKQKQNAHDTHSKAGTKAKKKEKGGRHFVVLPTGLGAILGGGDHWEPVVIEGVDDEVAAHCGLFIPEQNLEYAKLVERVGHRIIEWCDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSI9</accession>
    <name>A0AA38NSI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Squalene synthase</fullName>
            <shortName evidence="5">SQS</shortName>
            <shortName evidence="5">SS</shortName>
            <ecNumber evidence="3 5">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_340992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3 5"/>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000023">
        <property type="entry name" value="Squalene synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041361700" description="Squalene synthase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="493" mass="56619" checksum="FACEC0B28CE7C48A" modified="2024-01-24" version="1">MGAAAWLTLLLTHPVEFRTLLQFWLFHEQKRDITSMKEHATSGWDRQTMRRCWEFLDMTSRSFAAVIKEVEGDLARTICMFYLVLRGLDTIEDDMTIPDDVKQPILRSFHKLTVTPGWTYNDCGPKEKDRQLLVEYDKVIEEVNLLDPEYRSIILDITEKMENGMADFAHRAATAGATYIDKIEDYDLYCHYVAGLVGEGLSRLFSASKKEVSWLGTQLEISNSMGLLLQKTNIIRDYREDCDDKRYFWPKEIWGRKEYGFQEMKDMYAPGAQQRAQWVQSEMILDALRHSTDALDYLRLLKNQSVFAFCAIPVTMAIATLDLCFMNPAMFQRNIKIRKAEAASLIMRSTNPRDVADIFRQNCRSIHAKAVPEDPNFLRISVACGKVEQWCEQNFPSFVRMPSTAGNPPTFDPEDARTSILKKSQEIDQTITHRKRMAQLQKKQVAHGGQVKPAPEQPGIPWELFALFGAIFAILLLCILGVVWIVVKFSDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT77</accession>
    <name>A0AA38NT77_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_302819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT77"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03228">
        <property type="entry name" value="ABCC_MRP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="426"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="691" mass="77600" checksum="F5CDF48BB7BF0EF1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTW9</accession>
    <name>A0AA38NTW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_301849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="216"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3791077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="595" mass="66576" checksum="0C1E1967A7954739" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYD8</accession>
    <name>A0AA38TYD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_260511</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYD8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3789449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="501" mass="54716" checksum="CBB40ADF5F55C682" modified="2024-01-24" version="1">MSTRNYQNAINSLNSLQSNAATIEAVRASGGRLSQFAIPEMVEYLERIGYKTDELNALKVIHITGTKGKGSTSAFTASIIRHTKPDWKVGLYTSPHLVAVRERIRINGRPLSEEDFAKYFFEVWDRLQANDSRKLESTPFMPGYFRFVTLMAFHTFLSLGVDATILEVGVGGMYDSTNIVPKPIVTGVTALGIDHVGVLGKTLKEIAWQKGGIYKEGVPAFSVEQPEEGMQVLTERAKELKASEFTITSKLPQIDNIKLGLAGAHQVGNALLAVHLAKTFLLDLDPESVKDPFPQSFVDGLQSTRWPGRCQTVVDPQHPKLTWYLDGAHTIESLECCIQWFSQPGVGSPSDSTPGPFQRVLIFNTGGGRAGPSFLESVYKQLSLQLSQSGEEPASFFDQAIFCTNVTYADGGFKGDLTAVSLPPDDLAQLRTQHQLADAWSSIVPSFSKERIHVLPSVEHAIRIVHRLATEGESPVKVLVAGSLHLVGGVIEVSNLAEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYM3</accession>
    <name>A0AA38TYM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_343260</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYM3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041304236" description="CFEM domain-containing protein" evidence="15">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3789584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="197" mass="19209" checksum="7C53188564EF10B6" modified="2024-01-24" version="1">MKFPIFYILGLSLYVGLAVAQVLSQCATACVSQAAVKDGCVSFTNLTCVCTSAQFQQDALSCLTAECSSSDLTTLEGLQAQECGAMQLSATGTPSDTATFTASGISSGSGTSLSISSTSGATTTTTVSGSGSASTTVTSSGSGTIVPPPSSVLSSATSAASSAGSSASSPSSTGNSAQNVQIPLGMSFVALFAALWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZP3</accession>
    <name>A0AA38TZP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_54269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="79" mass="8859" checksum="0874F0F3E173B549" modified="2024-01-24" version="1">MTVVSTDSLVALLLPFSFLFPSFSFFVLSLFFYLIPALLSRFVALCFAERSPSVPAGLSFQSSLVTYLKFTTLFLVWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U180</accession>
    <name>A0AA38U180_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Voltage-dependent anion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_329434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U180"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="392" mass="43903" checksum="AB4AE479F312CCB4" modified="2024-01-24" version="1">MSEKQRVSTLARRIHGWSWQAFPIGMGTGAVYVTLSGLKEHSPTLTTVETIFYFLNISLFLLNTTTLMTQAILFPRQAWRLIKDPVKGIFVPLVVLSFATIIIGTINYAVPPGHVSPGFIYVLFWIYVAFACLTCLPMLMIWFNQPHDLATFTPAYAFLVFPMMLVGVIAFNVLKTMNPADPRAIGVLVLGYFFQGIGFFMTFFYLCIYIIRIMSTGFLEGHQANGAFVACGPPGFTALALLNLGDHARKILAAHHLLTPAAGDIWYASSVLSALMLYGLAVFLFVFGVLPYWFKVHKHLKEILGCWALTFPNVGWISCTRVLGDVFHIPGLYDVHLVMTILMCLTWAVLFVLTVIAFWKGLIFYSQDEDVLKDTRRDDEDKLSYSTTSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1E1</accession>
    <name>A0AA38U1E1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF2421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_64090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1E1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="6">
        <location>
            <begin position="102"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="557"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3791024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="102450" checksum="57F6A5792EA76FB2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1X7</accession>
    <name>A0AA38U1X7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_340481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1X7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="266" mass="30505" checksum="B21F985EAE7ACA15" modified="2024-01-24" version="1">MRVWAIAYDPSDFTEELYQKGLLLVDSTSSARIKRFYRREDACRGLIARLLPRILLKQRGVASNMMTFAATEAGKPYITTPDINPPIAYNLSHDKGFVVMAFTNGKAHPPEYSIGVDVMKVHLPRRDSYRSFVDTFHEQLTPLERKLLSPAVPENEGLQRFFWMWTMKEAYTKALGLGLSFDFSRIEFDVMANIVRVDGRVPQGWKFHKFQATKVEELYVGVVAEFLEDDSETLVVPETDPKPWFESFKAATFVEHAIRDLAQAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7K6</accession>
    <name>A0AA38K7K6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793871">
        <property type="protein sequence ID" value="KAJ3780174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7K6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="875" mass="97459" checksum="29FC63B92ACE98AA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K812</accession>
    <name>A0AA38K812_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_379892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793604">
        <property type="protein sequence ID" value="KAJ3781104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K812"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="293" mass="33591" checksum="27195A191D21C642" modified="2024-01-24" version="1">MPIKQFALTVFFQKGQTTLVQLPSIGSLESHAVTPSDAPSYKPDSTLSVARDIKKNSLHESSLLIAPPPTMPSRRSVTVEMPDSLRANVDHPLREPMQSIAPPLTTPRHRSITFEKPESSTALARHPRLQSIQRHEPYPTRSLVASSDHDDLDYYVPRLPDVQGHGHFLYTESDCHQRKKKVVTRWYTKASPGPLDHPPELPYNHKGLQDNVIFVHLDQQKQAETHFPRKKKASLKFITMWIWDASEARWEPIEYGAQRVIDGHRMRLSLYRGGADPEWISLQSWKRNSHIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9N2</accession>
    <name>A0AA38K9N2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_24095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793371">
        <property type="protein sequence ID" value="KAJ3784584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9N2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="78" mass="8919" checksum="2481263805E61AA2" modified="2024-01-24" version="1">MLPSVLPSRPALSDTTTTREQLETSQSLAKVTTPQETAIFICALQDCHKLFPSRDRLIQHRRKEHGSDEDKDIITWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9U1</accession>
    <name>A0AA38K9U1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_399890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793360">
        <property type="protein sequence ID" value="KAJ3784899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9U1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="211"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="554"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="944" mass="105755" checksum="AF1713A0B5E1ECCF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD32</accession>
    <name>A0AA38KD32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_362552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793448">
        <property type="protein sequence ID" value="KAJ3782878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD32"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="362" mass="40186" checksum="B77832019DB0F515" modified="2024-01-24" version="1">MSADSVGEPSTSTAGVNKPIITKTPTAKGNLSSLVSPTTHVQWKINEKCLCYHGPLIYEAKILKIRVFTPEDTENGEIGPNFLVHYKGWKQTWDEWVTEQRILKFDEAGIAKQKALSQSALAAQNAGAAGKMKDSSGKTIGNPAGLSISAGGSTRSGIRKEGARGTKRAREDDDGHNARRAEMKLNVPEILKVLLVDDWEAVTKNHQLVTLPRSPTVRQILGQFEDHVKSTTTSLPTPALLTHTICAGLQIYFDRSCGMSLLYRFERHQYAEIRKKYITGPQVKIEESSDVEMSSIYGGEHLLRMLVSLPQMVAHSQMDGESISLVKEYVNELLRYLESNKDSIFQREYDTPSESYGNTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDP1</accession>
    <name>A0AA38KDP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_118406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793586">
        <property type="protein sequence ID" value="KAJ3781226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDP1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="173"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="253" mass="28828" checksum="9456FADA399ADC06" modified="2024-01-24" version="1">MAYAPRGFHFDLKTVLSDPSPHINLDIPVYEETLQNFLKAVNNYKNRSIATITDRRTKDAVEKKKTQDRAQKIESEISKCKVQEIELMATLEKEQAERKDAELAVAAFRRQIASLHERSATMQAQIDEYRALIASLKTDKGKERSTLNAHASRVVPELHAFERLLACAIEGMEKEQLLISFRFVGISDPDREFSFILDVSGPNYKVVKTSPPLPSLPLLVDRLNITQDIFAFIVQIRQEFHRIANGEENMDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDR3</accession>
    <name>A0AA38KDR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_388679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793396">
        <property type="protein sequence ID" value="KAJ3783973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDR3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="238"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="440" mass="47693" checksum="3EDE39FE63602786" modified="2024-01-24" version="1">MAQSSSETIPTSIEEVQTTKIEEIQLGETNSRDDYAPTDGGWEAWGTVFGATLISFGTFGFVNAFGAFSDYYNEAYLSNYSATIISMIGAVQVFILYLFAGTAGAVFDSVGPRYLIPTSGVVVVFSLFMLSITKPEQIYQQFLSQSVLFSLGATFSFFPSMGLMAHWFKHKVPYAIGCLASGASVGGILVPIMISKLIPRIGFGWTIRILAFITLACFAVGTVTIKQRRPSKPFPKSVSALFDFSAFRDPCYVFLVLGCWFTVFAVFNPFFYVGLSAEVADPESNVNGYYLAILCAASIFGRVSPGLIAGKLGRFNILYISTLISSILIFALWYTSFAQANLIAFAALYGMFSGPFFSVTPSCVAEISPIERVGARIGGTYAFMASATLAGTPISGLFIKEQTKANFDKLILFSGIMSLVGTVLLLVARLIRKRNLFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDR7</accession>
    <name>A0AA38KDR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UbiA prenyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_402851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793394">
        <property type="protein sequence ID" value="KAJ3784003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDR7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="315" mass="34841" checksum="EE559FC272A7EC88" modified="2024-01-24" version="1">MSKRLANLIAPPSREEVNACWELCRLNNNMGCWTTWIPTAWALAMVYHAQPQISGAAALTWAAKYFVLCSGIKSLIMTIDDILDHDIDALVVRTKSRAIPRGAISLDRAWLFFSIQVVLGIYLARTLLDPVSCRFAAVAAPLFVIYPTCKRWMYFAPITLGLMFTVGVFMGWSTLSLTNQLPYEILVPIYIGGCCWVWTYETIYQHMDKVDDIKIGIRSSALLCGRHTIPICSATAITFFSLLMYGGYLNGHGIPFFVGVLLAAVLLLSKLLRTNVDCPGDCRDFFLQTPLIGQIIVGGFVADAVIARISNGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDZ4</accession>
    <name>A0AA38KDZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793524">
        <property type="protein sequence ID" value="KAJ3781796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="449" mass="49551" checksum="9F2718BCA438F578" modified="2024-01-24" version="1">MAPRINRGVSFFGLVGATMAALKLKEHFDGYNQLSTEEEGRVALHTPSAEYNDREAGLQTLEEEEGLLNTNIQKPVRKRHNPRCVCCGLNCGLFCKALAIVTVLFVIISVGKFIWWALTPSPTGLEGKPVFSEALGCLDASHLYNGGETTISIPVGDRHDHAIDVHGDAVGTLIVTEAPADINEVQYKLTIQSNDQSLLDQVTLQYPAAKPDGSSDGNSRLLIGTPRLNRDSSSCIRYDVTMYIPKTLKKLHILPHAVAHVRFDPEAHIDLEDTFVTLYQMDKRNLIEPHQNLRSTNLALEVYRGWIVGDAAIVNETSITTQRGDGVANVHVHPTAPADPTNPEQVSLRTTTGAGRTDLYFENDNAYPHRPIKSTHLSSRNADVYLTYKNAEFNGNVKLDSGSHTLTSTMPYSLRGQSKGHWTYWIGDMNGPGKDEISINSRGWTGLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE90</accession>
    <name>A0AA38KE90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_356192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793357">
        <property type="protein sequence ID" value="KAJ3784963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 9" id="KW-0698">rRNA processing</keyword>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="951"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="BP28 C-terminal" evidence="11">
        <location>
            <begin position="1995"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2261" mass="246967" checksum="2CFDC7AFE35E037B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEQ9</accession>
    <name>A0AA38KEQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_60968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793436">
        <property type="protein sequence ID" value="KAJ3783101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEQ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="22367" checksum="351524C97B5C6E5C" modified="2024-01-24" version="1">MERRSHSFDPKTKSVGVKKGKERNPRDEDEKVPLAPSSQKQSPFELHAIIILYMWPSSEQTGDHQAQLTCAFGYSWVYSPSSLFWLRSLTIALSTHITLAQTIRDWARRCTRYIRLSFCLYSFVFLLLFLILPFLIILQNSFNISLSSLYDSFVVCSFCLLLIFMILILLLYPRFLLSSYVGLPSSISLRYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF80</accession>
    <name>A0AA38KF80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L38e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_360231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="79" mass="9043" checksum="21B9C827C4CC8C52" modified="2024-01-24" version="1">MPKEISDIKQFLEISKRKDASQARIKRIAAKGRGGKVQTKFKLRCSRYLYTLSLDDPEKAEKLRQSLPPVLNVIEVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF97</accession>
    <name>A0AA38KF97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_360051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793406">
        <property type="protein sequence ID" value="KAJ3783746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF97"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041387914" evidence="7">
        <location>
            <begin position="18"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="54"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="166"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="377"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="527" mass="57526" checksum="A222272695989A38" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFN6</accession>
    <name>A0AA38KFN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_266128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="188" mass="20495" checksum="92633CA961E3C25C" modified="2024-01-24" version="1">MKAIEDALNGNTIVATASRASQPLVESRTYNKRPSDPALFEKDDAPSQKKKRHLPPSWSEEPREKAALKPTSAIMKHQIRDLSRTSSSNATKRPAGVFLSQEQSQILQLVEEGTSVFYTGSAGTGKSVLLREIIKTMKKKHKAADAVAITASTGKSTLMLMRSLNSRVQALRLVTLVALQSIRLLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGJ5</accession>
    <name>A0AA38KGJ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_432391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGJ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="496" mass="55605" checksum="BCFEA696857CC039" modified="2024-01-24" version="1">MAQPEIIDLTLTSSQSSDALSDDSGVQIIPQLKKRKSSNRSRDNKDSTKKHRSETPLDDSKLFLVDSNPSDALRPTTLSTASEKSESHEGRLLLPAHVSVIGSVPIEIIAPASEDQDYVEYLDFGDPEELGITRYFQLEPSKTKAPSVNVCKRCGTKGEHKTRDCSVIICLTCGVRNEHTTHSCPISKVCFACGMKGHLSGSCPNRGKLANAYDDCDRCGSSSHATNECPTHWRIYHYVTDAARINTMEVRQAKKTRPLGQGGEGYIAEDSWCYNCGERGHWGDDCEITQHVYDIPDGNSAFGHTNLLTGPFSEIETGKTDRAPREWELDSPEWNDWGGRVPTNVGRQAKKKEMARMRANLLEDDEDDPFVRLAKPMRDGFKKNIGNGPKPPSQPKKMRFELNVKGAAKEAPQSLLSRISSDAVSKEFSRPQADNTDRRQHSSGRSNRDREKNGYHDRDRPKQDIRSKREKDRGRDRGREERGPRYKGGYSNGYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKT3</accession>
    <name>A0AA38KKT3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_370011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793950">
        <property type="protein sequence ID" value="KAJ3780060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKT3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="726" mass="80009" checksum="44491CFF79E2A075" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLB2</accession>
    <name>A0AA38KLB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_429979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793563">
        <property type="protein sequence ID" value="KAJ3781394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="595" mass="65365" checksum="37290F35747BDFE5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLI1</accession>
    <name>A0AA38KLI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_128676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793637">
        <property type="protein sequence ID" value="KAJ3780870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="452" mass="49985" checksum="63755FC4E464703A" modified="2024-01-24" version="1">MAESRMIVFEANPQKATILTREEANLARDLFANFDTAWDHPALQSRLRQARSQPGNSASTLNGMTLFGVIWSSSKRPEFQKSQVVWKAMRAELENHGVLPRLVLEFNAYVTRNGKAHWRGMEKSISTEAQGPLGHSISSAWKDHEKRRRMRGTNSLVNPSSEPPPAKFFVRERPLPPPAPEIGSSTTSSSSYPFMRSSNLSQERHPSYNGQQELVGQGQFSHSSFPHPEIRPHSSLSIGSCAPSAPAQINSIFGVDETRQTQTFDQAYPSMPGVQYQHERLAHPLYPSSPFGPNSIPRETQRAATYGAISGPSNLASTRYSSNIPQTDSFSSQAYQTESLLPPMSYSSFSSSPSFNPTTAYNPASVPPQVDHRNDYNLQSGNAYARNRYESTQNENGQSFEYDGGLVHNSGYGDGRAAFQSNRSVDESEAFKAFCASYDTGSSSYEGNYQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLQ8</accession>
    <name>A0AA38KLQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_91387</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793509">
        <property type="protein sequence ID" value="KAJ3781979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1331"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="526"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="992"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1054"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1116"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1072"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1174"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1233"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1301"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1330"/>
            <end position="1349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3781979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1459" mass="154368" checksum="88587815A896B922" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLZ1</accession>
    <name>A0AA38KLZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_379428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793547">
        <property type="protein sequence ID" value="KAJ3781545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="411" mass="45696" checksum="772F7D337498D0AB" modified="2024-01-24" version="1">MDPLLTCATNRVMPTVAAGLVQKPLLSVNQEHSESDPSITSSQIQSSSSKSIPTLPAASVSSTFSDMLCNISGSRWIDMGTLKAGCQLLILNPTLNALEELWGYDITNLEDCKISDEITKKKEFLHCFAKWGNLKNTIAEISDTLMSKAWIKVDGTSVDLKDFISCPFFDTICDKILGNDWACVYDLKHEKYVMLSNATGFLKLVTLMETHNHHLCSTMYHCSNKVLQALIMQKLPEKFHADLCDCKVSENLPYNDWKMACKDVEEHCLPILPSASLGAKQADFCVERPPSAVSYGNNPVPGVSNSTTFQSNARSNRFPKLHPKQKKILYKRLKACYCCYNLFVGHLSNNCPNNGPPNLSVPFRPLNKNDVTLATCIHTATLNNSIPYELILKRNSVPGLSTNLAFLFRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMB6</accession>
    <name>A0AA38KMB6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_69671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793448">
        <property type="protein sequence ID" value="KAJ3782879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMB6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="269" mass="29678" checksum="B61FD390524AD7D9" modified="2024-01-24" version="1">MDHFPTNWGRPRNDGFDAYGTYPIAQRPYNGLGNDVFSEGVQRTQQPIVTGTSVLAIKYKDGVMMSADNLASYGSLARFKDIQRLHPVGNNTIIGAGGDMSDFQYIQALLDDLMVDEFTEGDGDGHALGPGEIHEYLSQVMYARRSKMDPLWNSLIVGGVKDGKRFLSYVDLLGTTYSASTLATGYGSYIAQPLLRKAVEGNEDNITEEEAVKILEQSMKVLFYRDARSLNKYQIAKITSEGVAISESRSVDTHWSFADGIRGYGAQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMF0</accession>
    <name>A0AA38KMF0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794493">
        <property type="protein sequence ID" value="KAJ3779631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMF0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="74" mass="8054" checksum="AAF8D64880DDAF15" modified="2024-01-24" version="1">MGLRTYCDPVKAMQPERIMIEVPGAPDEVSSVGTVAVTQGDTRKGYMVLGSVPAKCEEERSSGMSDESDRSIWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMM2</accession>
    <name>A0AA38KMM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794114">
        <property type="protein sequence ID" value="KAJ3779871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="611" mass="67963" checksum="CEDFD038327E8DAF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMS9</accession>
    <name>A0AA38KMS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_236811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793958">
        <property type="protein sequence ID" value="KAJ3780051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMS9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7274" checksum="427F27383A7B4DE0" modified="2024-01-24" version="1" fragment="single">ENAFQQAILNISNGDTYRTAAQRQGLPMSTLWHREHGRSTRSEGHEHLKKLTTIEEKELRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNX5</accession>
    <name>A0AA38KNX5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_359902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="MU793404">
        <property type="protein sequence ID" value="KAJ3783780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="83"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3783780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="404" mass="44236" checksum="5C38EAD1721EB918" modified="2024-01-24" version="1">MAQPDIKEATKSRTFRFPIPDEDQFDVSPLPDFDDEERVQQYLQDRRVIGYDPLVQPALLRHEITSSANSHRTIASARYSAASILSGHDDRVLVIVGPCSIHSPEQALEYARMLKAKVPTWPNLLIVMRAYLYEKPRTTVGWKGLINDPDINGTFKINKGLRAARQLLCDLTDLGVPVGSELLDTISPQYIADLISWGAIGARTTESQLHRELASGVSFPIGFKNGTDGSVTVAIDAMHSASNPHAFMGVTEQGLASIVKTRGNQDVHVILRGGTKGPNFSTEHIKDAAKTILKKQKFASIMVDCSHGNSQKNHNNQPRVLQDVCDQLSAGERNITGVMVESNINDGRQDVPSAGPTALKHGVSITDACVDFDTTVDMLNKLNEAVLKRREVILETKTKTAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP49</accession>
    <name>A0AA38KP49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_388636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="193"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="392" mass="43754" checksum="66E44B9C5C7CD11E" modified="2024-01-24" version="1">MSNTTSPPMVPFPSTGVDLSSTFDAFFYGVIVSVGLFGISVVQLWTYINLSRDRWMFRVVVITVFLMDMATTYLDIGLLHSYLVSHFGDLTIFATPETLLDLEILFTALIVFVVDLYFASRVHLLKQVHWSVVAFIVGSNVIALRKATFRSSKSDANSSAGRSYQHLVGDYIHPFSILCKARIIVALENAVTTVCEVVATVALAWSLHSSRTGVPRTDTILLKLHTYTITRGVLLTIVQVLSLAFYVGQPTKLTWIAFHMCLSKLYFITMAAMYGKSFSQKYTQMTRINRLNTRSSLRRRLDRTITDSEVGRIIQQSGHSFARGTSFVLGSSIDANVNTDPPDFGLTQISTHDTEILDEHESVHSIKALQPIVITRNRISTVDYQSTGKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP54</accession>
    <name>A0AA38KP54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_108522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793553">
        <property type="protein sequence ID" value="KAJ3781491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="263" mass="29961" checksum="E7D027CE019B6C43" modified="2024-01-24" version="1">MSWSGFKKSVNRAGTTLLQKTGQIERTVDREFTDEEAKYRTFEKECQALQKDSKAYWDAMKAMTAAQTRIAETLEIFYGSADRTSEGAMAGHAYKRSVDDLDGGFGRELDLPYRTAISEPLGKMCAYFPTVNEHIAKRNKKLLDYDSARSRLRKLIDKPSEDPTKLPKAQQEHDDAKEVFDMLNDQLIAELPQLLDLRVPYFDPSFEAMIRMQSKFAEEGYEKLSGVQRYFDDSVRDDYAAGQLDAQVEGVLQEMRELSICGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPH7</accession>
    <name>A0AA38KPH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_357829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793377">
        <property type="protein sequence ID" value="KAJ3784410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="290" mass="30194" checksum="E945C61DE35E43A8" modified="2024-01-24" version="1">MAGRLAQVSGHLSNAYGRGLLAGEVAIITGAGQGIGRSAALIFANEGAKVVISDIDANRLATVEEEIKAAGGDSLSVAGDVGADEFPKRIVDATIAKYGKINHIVNNAGFTFDKMLHTTPDDTWDIIMKIHVRAPFRLVRQAAPYFRVKPEHRENRSIINVSSTSGLHGNVGQANYAAAKAAVIGLTKTIAKEWGPFGVRANTVAFGLIHTRLTAAKEDGATMEIDGKKVALGVPGAKPPSDAASDAYPLIPLRRGGNTDEAAASMLFLASPLASYVSGHCLEVTGGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPN3</accession>
    <name>A0AA38KPN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_314744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793371">
        <property type="protein sequence ID" value="KAJ3784590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="174"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="486" mass="54121" checksum="46551C14B37C7F28" modified="2024-01-24" version="1">MLESIRSHPRSITNAPRQISCRSTNASSSSSSKIAKSIKSVDICAKLITDRNGHKEVIGLGINKALTIGRNPERSFYVIPDSSVSGLHCTIFAVRSPSGGVIVSCQDSSKNGIILNGHRIKKASVILMDGDLLRIPDSLTFTCIHLWKDPIEKVSVFDPTPPPQPARKHIGRYIVTSQCLGSGSFAIVHLALSMDRRCQVACKSIRTKKGHRDELGQVMKEIKILMGLNHPNINRIYDTQEDQNFIHIFLQLCTGGDLFTYINSFTEKNCKMEEDEAKYITFQLLKGLAYLHNKSISHRDLKPENLLLYAPGPYPRIQIADFGLARPKSYQETFNVCGTVSYLPPEGILALDQKNLGYVGMPSDCWSAGIILYIMLSGSHPFDYALPSESWLSQHASDSRRGSHADCSQNYLQSEARLKERIISGQVDFQQLLWSKLVKAKVLVNLLLIHDPSKRATVHEALQSSWITDDLAMLEGAYRSRIVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQZ0</accession>
    <name>A0AA38KQZ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_295345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="355" mass="40074" checksum="52E4DEA9B5301C67" modified="2024-01-24" version="1">MLYSTYFVTGASGLLGSQIVQKLLDAGHTVRGSARGEKVSQLKKVFASYEKFSVVDIPDLATSSLGDAFKDIEVLIHVAAFLPSFRGDIEVVKRFSTEGTERILESARDAGVKTIIVTGSQVTYNIDGPIGPRDWRFVTFDDAQKATEAQHFVVYIAQKILSEQTMMNWAEKHPDVRVVIIDPTYIFGPFVRNYKYIVNHPSLYGLESSNYFVHFLLRPENKVFVVYPGWMDVRDIADAHINAVHNKAIDELLPKDRRFILGAPEDHDWKKVISHVVEARPHLADRLCSSEKAPVFPMQVTDLQRTEKYLGIKAGSYTSFGKSIVDTIDSILDIETYWKERGVEDLSLPNEPLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR07</accession>
    <name>A0AA38KR07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_311453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041394769" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="60674" checksum="B3250DD7076D6936" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRC2</accession>
    <name>A0AA38KRC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_376868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793382">
        <property type="protein sequence ID" value="KAJ3784296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="717"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1455" mass="154977" checksum="56832B978DBD011B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS54</accession>
    <name>A0AA38KS54_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_345595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="127"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="609" mass="66681" checksum="00191FEC3FBC048F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSH1</accession>
    <name>A0AA38KSH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_353773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36806" checksum="618F7912C6FC6FBA" modified="2024-01-24" version="1">MAPRFNPKRDLVDLHGRVIIVTGANRPLGLGYSTVKHLASAGAKVYIAARNEQQSLQSIEKLKADLHLDPSDGNSGQVHFLKLDLGDPRDVKKVAEEFLAKESRLDVLVNNAAMVFAPFEKTSDGISKIVVTNLISPFVFTQTLLPLMAKTAQEENSDIRIVNVSSITHYIANIKKLENVEDLNQEYRRRPLAKFTRYAHTKLLIIIWTRALHRYLSSLSSTMPGMERITAMALDPGNIDTFSNRWPLPWLWRPFVRLLMTAPNVDVGAYPTVFAAAGKAIYKDRGKYAGRYLNEKMNVVNPSSDARSDKLAEELWTLVEKTTNDMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSV9</accession>
    <name>A0AA38KSV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_263007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSV9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prospore membrane adapter protein SPO71 PH" evidence="3">
        <location>
            <begin position="352"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Mug56/Spo71 PH" evidence="2">
        <location>
            <begin position="876"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119912" checksum="7D5729D100914A8D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSY7</accession>
    <name>A0AA38KSY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_286150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000069">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="419"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="560"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="621" mass="67508" checksum="356B8E12E6B774B3" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTV2</accession>
    <name>A0AA38KTV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793607">
        <property type="protein sequence ID" value="KAJ3781077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTV2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041211261" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="66" mass="6737" checksum="6A139E295DED97BF" modified="2024-01-24" version="1">MRFFAFISAILIAAIGVGAIAPDPDSACRCPNNCQHKLGDSCAFYQDGNVINGACVNGNGGLTCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU24</accession>
    <name>A0AA38KU24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_347601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="35239" checksum="636C22F31AE936DB" modified="2024-01-24" version="1">MASVGTILAQLFPPEPKWSVDSIPDLTGKVAIVTGGNVGLGKATCKQLLLKGCTVWLASRSKSKAEAAIAELKEETGKEPLFLALDLNDLQAVKESAENFKRRSTALHILICNAGVMVPPVEQVTAQGYDLQFGVNALGHFLFIQQLLPIMKSTSSPVSETRIVWVSSSVQYYFRGPPVNYDNITDTPSRKKLGTQQLYCQSKFITVMLAYHLAKVLAEDQTSNVICIVLDPGNIKTDLQRHHSPSMLRSIMNWMILRPVSSGILSQLFAATDPEAAHLNGKYLRPWARLGEPHPKTKDEAEQRKIWDYCMVAIQTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW35</accession>
    <name>A0AA38KW35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_370282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794280">
        <property type="protein sequence ID" value="KAJ3779738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW35"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041258723" evidence="1">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="184" mass="21057" checksum="4571A958969F181C" modified="2024-01-24" version="1">MHLNPAYLLFALLSPVAYAAPTTAVGSNLSRRGQLLDDNTVHVNISGDPLRTYRSFNKNDHEYLQPRLETIFQYWISSMEMFKLSKEGKKISRDMIVPPDLLKPLNIVIEKESVPELEHFRFTFWGSGVKEIPGFQGCELEGDRCGGYASKWIVFFNRNGEDMYYANRNKTGFGAPVEAWRISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW62</accession>
    <name>A0AA38KW62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_375810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793342">
        <property type="protein sequence ID" value="KAJ3785427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW62"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041316424" evidence="1">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="175" mass="18567" checksum="AD28B5E990564955" modified="2024-01-24" version="1">MRLNLAYLLVGSVSLAYAIPVEPQAAGSASLSFQVDGDSGVELSSTVAKPSHVWDSTSPSPLARGERVTMLDARGALSSLSLAGKTKLAVTVTIPVSIPQSTKTKINKLVKGFLTVYRPLSNFEIELKDDPKSSQGSGSASFKVKIADKVQEWVVDYVNSRITEVKKGGQTSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWV1</accession>
    <name>A0AA38KWV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_351462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="19952" checksum="428C84DEBAE7D257" modified="2024-01-24" version="1" fragment="single">MRLDVTETVTEPIQSMLPPSEAATVARTAESMVQDTIGSSQTEIGDVIVKPSDLQAARPSAKAQTLEPVAEDVVTTVQDELASTSPTFASAQLRVENVDDNTTKAPESIHIDEPTGPVVLAEENDQNEIHAEAEGSDEDGEDEEDEEEESCSEKEALEEVLKIEQSRSICTLCRARHERYPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX98</accession>
    <name>A0AA38KX98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_349414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX98"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="241"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="514"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="775"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="817" mass="89891" checksum="0B620D74E7B1E885" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXA7</accession>
    <name>A0AA38KXA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXA7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="129" mass="14336" checksum="199553667407661A" modified="2024-01-24" version="1">MSSLRLSRAFLGSQKRLMSSTPTPKLHKFVLFAPDTKDSARSTVQKQHREAIAPFVQSGVVKVAGMTVTPESIESEEAAVKPFGSCIIYEAENIDVVRKMVESDIYYTSGVWDREKLVLVPFLPVTSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXE1</accession>
    <name>A0AA38KXE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_436997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793515">
        <property type="protein sequence ID" value="KAJ3781898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXE1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="3">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="260" mass="27034" checksum="15CF9D01073B96AC" modified="2024-01-24" version="1">MAISKKSSPIKTKTPSGKSHNATHPTWIDMIKECIIAYPEDARTGVSRPTIKKFVENKYKIDVNASTASQLNRAITSGSEKGVFVLPKGPSGKVKLAPKVRSDATKENATPAVKKPVSKSKAPSTRLSASKKAPTTKASAPEKVRPPKASAVLKSSPTKAPTVKKYSSSKKSAQSRATTLNKKIAPSKNSASTARKPSNPKKGSTTKGTAVAKKSIAKPKVAKAKSSASKAKASVPKAKPTAKASARPKSATKKAAAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYZ8</accession>
    <name>A0AA38KYZ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactose mutarotase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_27789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYZ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="433" mass="47512" checksum="6AF34D1DFBBEF071" modified="2024-01-24" version="1">MTDFDPILLTLPSLAPSLAVEILPYGLTFHRVFVQADGRTHDIVIGPEDPRGHITQKYTNTIIGRYANRIPIGSHTIERNGVEAEVVAELNEGSRVSLHGGPVGFDSLCWTRLTPDTPPALFTEAELAHLPPLSVATSYGIFRLVSPDGDQGYPGTMSTEVLIALIPPAEQERKYVEPGQVASSAEWDLGSILYVYRAKVDKGVTPVNLTQHWGFNLEASLKDGEDTLSVKNQNITIKSDRIVARDADSLNIGNFIPVTSATEHLHEGQKIGDKYPNLGYDDYYAFAPRTVKIPKRFPISEFTPKLDLLKDVLIPSGTEDATRGDRPEPVVELSSDKSGLKLVFETNQDGVMFYSNAWADPSKGARKKIHGGSGIKDHGDGYVPGTAAFLEFHDILAAFLDPANKDGNDTLLTSDEVYHNYVRCDVRFKQPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZ07</accession>
    <name>A0AA38KZ07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_23889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793371">
        <property type="protein sequence ID" value="KAJ3784568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZ07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="66120" checksum="62309734B13D7F06" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZD6</accession>
    <name>A0AA38KZD6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_5745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZD6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="618" mass="65963" checksum="5039A771CCC0CE9F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZI9</accession>
    <name>A0AA38KZI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_375575</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="291"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="954"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="965"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3785693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="993" mass="108433" checksum="DACC52DD362AA4B4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L022</accession>
    <name>A0AA38L022_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_374393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3787013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L022"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="599" mass="63744" checksum="F74C3B239A6A357F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0R4</accession>
    <name>A0AA38L0R4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoglucomutase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_345262</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0R4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="46"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="226"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="324"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3788753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65773" checksum="D2695E5D42E6C22B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1Q6</accession>
    <name>A0AA38L1Q6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_391290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793790">
        <property type="protein sequence ID" value="KAJ3780322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1Q6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="160" mass="18391" checksum="6F391C227CF46AD6" modified="2024-01-24" version="1">MSTEPKAKAVHFDVDTALSATKHSRPLRKKSRIPSFSSPRAYAIVMPFDEMLARAKKENPDVQKLIDERGLWQEIAEVNIMIAELCDKACELWPNAFMVLVDHRSFPTSLQCIGLADNTHRINRTLPTADEIQQIRDRLDINGAEFKLGWYRDLYPDEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2X7</accession>
    <name>A0AA38L2X7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793670">
        <property type="protein sequence ID" value="KAJ3780700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2X7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="196" mass="21707" checksum="1BECB4800EAE203F" modified="2024-01-24" version="1">MVIVISTPSLRRLRSGNTPSDILKKEPGTVTSSLKRSKTYTESSSSSESSSCSLSTSDVPVTSNSTSTAIRSRLNDQQRKDRLEQDLDVLEESVRPRSVQCKGCTHTIRLDTKINYGDSNWKTHKKRCPMLKKKTHSKTVDQVPVPKPLLNISEVPLEGTSKSSCGSYMQEKLSDLEYSAVLGLLAIQRKMNPSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5C5</accession>
    <name>A0AA38L5C5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_394200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5C5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="405" mass="44370" checksum="5DE619498E2D7048" modified="2024-01-24" version="1">MLDIDIVGGGLGGLATAIAFRRQGHFVEVFEASSATAFNELGAAIGCPPNAVRILKSLGITVESIKGVEYAGITSLDHQSGTVGLSASLGDIKGQYGHVWCLCHRVDLHEVLQRMAFGEEGEGPPAKLSLGTRAVSWDPKTNELALSNGETRKPDLLIAADGINSALRSAIVGQDIVASPTGVASYRWLLDSAKLDNNPQLDWVIRNGPSGPRMVTSPDFRVLFLYPCRGKTIINAMGIHMDDRIQTQVGFYVPSTQAKLLEKFKDFGPQYQQFLELTDEEVGLWQLRSMPNLSTWINGRSCLLGDSAHAMLPTIGQGAAMAFEDAITLAHLIPLDTPCEDIPRRLSAYEFLRKERADFVKGESLDQFIVPQKRALYYRSPELQKRVMGFDAAATAREYKRANFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5J3</accession>
    <name>A0AA38L5J3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_264869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5J3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117935" checksum="014A20A79802DEED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5L8</accession>
    <name>A0AA38L5L8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_291912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793337">
        <property type="protein sequence ID" value="KAJ3785590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5L8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041396891" evidence="2">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="85" mass="8892" checksum="42D8C108FF6E098C" modified="2024-01-24" version="1" fragment="single">EFHLVHVLAISVLLLNKILLTHDFHLIVPGASSSSSPPFVSELNLPAGLSSPDTTWLDFLSSTPAPSSSLGGLSINSVPTSWGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5Q3</accession>
    <name>A0AA38L5Q3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_308482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5Q3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="337" mass="37560" checksum="07F1F49DE7E5B576" modified="2024-01-24" version="1">MFYTMLSITGIVLVIGLSYVSNVRARITDVILFGDSYTDQSRQHSIANGTYPGKDYQEVFPPNDTAADGGVQWPWYLGLYGNYTIWNYAVGGAVCSNNLTPLYEELDVSTGQQAWFIQDHIDAYKTSHQKLLLDPSSFVVVQFIGTNDVGIGSFLTTDEAANVSLPDVADCQLNSLKSMHALGARNFILNSLIPLQLTGLYSNSSAPTIYYPEVHDGNAWNKGMYNLVHSLNRMLSDGIDVLNAEWAGDGRIEWFNTYDLFKTMYNNPTQYFNGSIPANVTGHCHQCPDPDDYTQCGIGDCTLAERDSYMWWDELHPSEQTGRNLAAEIFKKIEGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6B6</accession>
    <name>A0AA38L6B6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_431910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6B6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="180" mass="20360" checksum="9EDC9E0974AE8FB8" modified="2024-01-24" version="1">MVLRNRNKLRICVAFYYRGVQHIHDDLFHTAILLLPKSQDESHTSRFHVTNSLKPGIVLVNDRVPWRYESLSLDYVRTNRLNAFLFLGKLSPEIGVEDFNAILFHLPMVQDDPGWNCNSWTVSAIRLLQEKGIINAPLSANQILFNGLQFASTSLLDHNLPVATCDVHGQSIDSLAKAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6N6</accession>
    <name>A0AA38L6N6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_373516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6N6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="133" mass="15159" checksum="665F0A4B255232CB" modified="2024-01-24" version="1">MVNKSSSIISSIILNSTALGVSAYLSWSLYQTYNAQVFTCVGAPKAITDLYKYFLALQVTLQLELFVLLTAAGLWTSQLFNSYITHISKHTPIYEALVSGMGRRVMRMNGRERSWEEKDKEEKKEEEISRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6Y6</accession>
    <name>A0AA38L6Y6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNase P/MRP, p29 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_426093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6Y6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="237" mass="26660" checksum="743D77665880B3A6" modified="2024-01-24" version="1">MDIYAQSPVPFNQKGRLRLSSKNPFVPNFVQESLLPSVNSSEIYASRVHGRKILLDNPVGKKENKTKRKKRPIVQCRMPRMSGSLTLDLHQANFNLFVPLHHLWMGYMSELLALNSAETPSSASTHPKLIKADFSGSFVSVQMSKNPSLVGMQGIILHESENTFVIITRSNKTKTLPKQNTIFTLYVPAYAIVNTIPSTAIVLDIPHLAFTLYGNQFQFRASERAGRKFKSKETIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L741</accession>
    <name>A0AA38L741_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-Cys(6) binuclear cluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_384578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L741"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="541" mass="60412" checksum="5FBFA97BB7003ED9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC37</accession>
    <name>A0AA38NC37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_406785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793451">
        <property type="protein sequence ID" value="KAJ3782821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC37"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="452" mass="50718" checksum="E7F1BB5347871DF8" modified="2024-01-24" version="1">MLSSELVLPVELIHSIVDICAEGDTPVDTLKTLTLVSSCLRPRARKRLWEHVFLPPKQAIWLAKEGRDYSEIVEGLAAVEDLSTLAKYLHLNPYPPGILSLFLHRIHFVRVKHVFIQGYNARAPAATAPRALGYFLSQNSDLHTLELSSARINALALFDLLSQSQLRALRTLRLSHLTLSTGDGDDEHLQEVTWDAVATFLSSRDGCIERPLLQVLDLNTVYILSSRPLTYAFFSHPKSLFDISSLRKLTLHISRTTNQTLNDFASVIDLCYYSVQTLIIYGWQDVTSSSSYLLGKFQNAEKVELVIHGSGHGSADLLVNSQPPESSFALAFQQLSKLTRLQKLTLRLRFYLDAMTILNESLHEMLMILSIQLPGIQEICSYLSPAITVQNNINMFLWAAVAVDGFTSYSVFSWNQTTRTLTQETTGSHHNEQSLDSDLLQTLMKARPRTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDF7</accession>
    <name>A0AA38NDF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_350000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3786991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDF7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="549" mass="59232" checksum="1C4F2C0DCDFEDD3F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDI1</accession>
    <name>A0AA38NDI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_265399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="928" mass="100249" checksum="2E970AF383448B9B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NEA4</accession>
    <name>A0AA38NEA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_344598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NEA4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="187" mass="20927" checksum="91A6B6BE958BF014" modified="2024-01-24" version="1">MPVEVKRRKIAVLGARSVGKSSLVKQFVEKQFIDSYYPTIERAYVKSIAYKGNEYVLEIFDTAGQDEFSPLKAQYAIGIHGYVLVYSIASSNSFEMVQILHDKIIDYCGVTDIPCVIVGAKSDLHSNRQVQFSELERVAEANNAACVETSAKDDVNVGRVFQLCVQEIERRLSNNQAVPQANRCLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH85</accession>
    <name>A0AA38NH85_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794040">
        <property type="protein sequence ID" value="KAJ3779942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH85"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="413" mass="45459" checksum="F426197C76208E1B" modified="2024-01-24" version="1">MKYQIKSTLQGPQDAITSLAFTVQGKLLAAAGPGGVSVSSLATSQLVPLVSGIGGYQQPERTAFPVVAWLFYKEQSRHVLMLGSWDGQLQFWDYVDERSTLESTRQAVRHTPLAQVISVDIFPKEVPAGGRAKIVTSFADSSVSVWTLSMNGELKKKFTIKLHISFIPKAVRFDTKTNNIYVFAMNGGDIAFLDCHTGNTIWMKNGGPTVMGSISLNPTSENFAVCTSQGFELFELERISYIRKFDGEPIHITVPKHLSFVEDGSKVLGGTDRGYAALYDVQSGKVVQKLKYSLGGLVQLVAACAMNDDFFTAIAGSNGHQRCDVIVWQKPRPIPRSRHMEGNDEYVVLPVKKKSLRRFAYIAGLALSFFGYTAFVTLLSDVCRRLSHSGAFSLTLFARVSNLIFVSAPRNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIX5</accession>
    <name>A0AA38NIX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_381678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794158">
        <property type="protein sequence ID" value="KAJ3779839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="37"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3779839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="167" mass="18643" checksum="FFAA8A160796D08B" modified="2024-01-24" version="1">MLQAKMKKRHLTMIAVGAFSFVCLDCTYASQVSVQVFSSGSALKVRGPAAILIGWIIMGVMLAIGEISILYPLSGGFAKRFLDPGFALAMGWNYFLQWAVVLPLEITAARTTVQYWTEKVFIAVWITVFWVVVMIICLFGTLDYAEEKFWSSCLKLLIAAMFIFIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJG4</accession>
    <name>A0AA38NJG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_134524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU793660">
        <property type="protein sequence ID" value="KAJ3780754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJG4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="629" mass="69932" checksum="1201CEB672FCB82A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJI4</accession>
    <name>A0AA38NJI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793639">
        <property type="protein sequence ID" value="KAJ3780859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJI4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="199" mass="22060" checksum="10F260731BF41E3A" modified="2024-01-24" version="1">MDSKSQSSETDPAPSTPIPTRPVAPTKPLKPIIGKLPANYVPPQERSIGILPKEDSRNFRYKAPIESEAAVSRVIEAGFNSTVSVRHEDLLAIAPDYRRRMKESVTGKRIGIEGNFVNGGEESLMLELPYQNDDTFQSYFNHFGNAEEGDGFYVAKLAHTIRAINAIIGKGETDEFNGEPDDKRVVPHVHYKPFVIHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK53</accession>
    <name>A0AA38NK53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_363437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793468">
        <property type="protein sequence ID" value="KAJ3782553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK53"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="324" mass="35509" checksum="F3DB1686680BE869" modified="2024-01-24" version="1">MVFRLPSQLESFVPAPASQAPNTADAVYTPWRGQFLVSGTRASDIGSNVNIRVTGVETDGDTSHRQSHLWPSRFVFSVTSPHALPILPQLQTYMRHRSPPIPLTTFVPDRIRDPDQNAVNQSQFRSLSRLLWDGQLVAIVVIALTRSSTTPGGPGRHGILLFPSPNSSAVLYGAVFLTSTDTFPDFVLVQGAIQATPPSFAHTYGGSMPRGRSSVPTFIDVHPRGYEQHHMNPMPYSSGSQIQSQGSQRHSSHSVSPTSAAEHHSSYRYASPIPSQNRAAYGQSVAFDDNSAEYVARYQSESESPTDPNSVYQYPTRGHSGYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK64</accession>
    <name>A0AA38NK64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DEK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_163888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK64"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46373" checksum="8DD3D2FCAF68F30D" modified="2024-01-24" version="1">MPPPDIKVIGKLTREIVSDADKSGTLSKLTPRIIREKLEEDLALEDGALKQLKHVIQEAITKALEETRDDEENNEANEEDDWQEERQNVASKVETKSAARKEKQKKSTEKPLDKKPSQKPPKTEPSSSDIPAKGKKRKSEADVSSSKAKKPRVSNDAKSKVKRDKEAFTSAAVVPPSSDFEDDIPAKPTEDNIPFADKTSPRRLSSKRTPSPNKPKHDSSPENSSKSGSPPQMEEAEKSESELSVLIDEPPKLKKKGKAKSSEISEAKEQKKTRKGAASTSLSKDEETIKRLKSLVNACGVRKVWSKVFKDINDSPSKQIALLRKILADLGMTGRLSLEQAKTIKERREFASELADVQSFEQSITNQSSRRSRSVATKEESSEAEKDSDEENVRPAKRKTNARQSIMAFLEDQSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKM2</accession>
    <name>A0AA38NKM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041215900" evidence="1">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="147" mass="15561" checksum="A72B6B205FA9A0E0" modified="2024-01-24" version="1">MHFNFLMLTSAIFTAISFVERAKAGTIQLRDGEIATKETILEWISTTDANLTFIGDPITKRNIESTMVVYCSVRTVDVCGGACTVYNGGATCLNAPDTNCLSATNNVGFCDHSGCGGSCNQLSSCGVRLDDGFCYTPGTNSINVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKS1</accession>
    <name>A0AA38NKS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_264407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="114" mass="13731" checksum="D14201F7817565E0" modified="2024-01-24" version="1">MRISLDLEDFKCWPIKVKRKEGIRCLDVYEAIFKTLQYRLTDDDVRTFGEARIRRCWNYCLQRCIDSPGLSEYNKQRGIRRVDLLRGRRFFRGLVQSGDNWILYLDDYSGSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKU1</accession>
    <name>A0AA38NKU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_274154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="345" mass="37965" checksum="AE85EC2EFB4C5C5B" modified="2024-01-24" version="1">MISLLSISESGLLSRSSGLDNYQRWTKGCSPKFGPVVDELDIIEGRIEGREASSISCQLLWVGPKRTEKVILHFPGGAYMFPVSEMVFKFWKYAQLEWEKQGLEVGIAILSYTVGPGKDAAFPIQLIQAIHALKHLLSMGCNLSDIQLVGDSAGGNLVAQLLLHMVHPLPLPSNLVPPLDLLPGARLRGVYMMSPWVSLSDPGQWGSSMHTKDNDIIIYKTGRRWGDIYVNNIGNGGILSNVSLAQLLPYAEPILAPNNWYSHLPKIVNRILVSAGKEERLLDQVQALFDNKIKPYFGDVDGTLVLQDGGVHDDPMLDFAVSDVPLGNPLTAVVVEWIKEGFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLZ6</accession>
    <name>A0AA38NLZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SacI homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_313238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793347">
        <property type="protein sequence ID" value="KAJ3785284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLZ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="125"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="661" mass="75522" checksum="7D3207CFE88E8F03" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMQ0</accession>
    <name>A0AA38NMQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794852">
        <property type="protein sequence ID" value="KAJ3779465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMQ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="274" mass="32407" checksum="9E467E22B34ECD8B" modified="2024-01-24" version="1">MVQIATTDLNEGCFHALIDSNVYTFVHGKPHNFPVIPPKDQVLDSSNKISLPDFYNPTWVTRNYPFLGFVPSSNPFKCTFLRCLDYSFDMLPIDVVEERPLRFRLRPSLVKEWDSLERNMRLFLHACMRVSRMPYPDLQLWSYPSYIGYLRKWPTMLSARQAAYRSSQAFIPLIASISFFLHLLYSADNKWEKIIQSTSPPVALPEEHPNWNFWSERQKEEAKFRHVSVLTKWEWKSLLQEETKISWEWLSYFEEEVLKVPMQIYLSCYIGGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNB3</accession>
    <name>A0AA38NNB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-rRNA-processing protein TSR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_126114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041274835" evidence="4">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="210" mass="23277" checksum="392A02A68B99C739" modified="2024-01-24" version="1">MSSAPPSPALVLFARGVIARLAIWETLTLAVQESWGGPGAAEKRTWMAGVLVDMFEEKQSKNNSASSAHDDSRVDPEDIEDTLLQIMADEFEVHVEDGSAEILGKDIVRLWGAIINSADTGSTISSSASEKMVQEWESRAEITKGRKVHAHYQEAIEEDGDWEDDDGDDDDEDNDLPMAEAPQLIDHDHSRREPEVDEDGFTLVSSRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNM3</accession>
    <name>A0AA38NNM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component CSL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_344807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3789003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNM3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="186" mass="19888" checksum="8F990326812CB6CA" modified="2024-01-24" version="1" fragment="single">MASDLVIPGQPIPLPRGPVPQLGRGIYEKDSQVRASLVGVPRFEGSSLVISRVRPQPPASNSVVLGSITRLSPLQALLSIMVVDGIPLPPGEEFTGVIRSQDVRATEKDKVKIGDCFRGGDVVRGLVISLGDARSYFITTARNDLGVIFATSEAGATMEPVSWQEMRCPITGKVEKRKCAKPEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNR6</accession>
    <name>A0AA38NNR6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793578">
        <property type="protein sequence ID" value="KAJ3781280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNR6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="142" mass="15642" checksum="E8A2A7491C081674" modified="2024-01-24" version="1" fragment="single">PDPRVNSRVKGQGRVRSGRPHEGQGREGLAALALAKRRLPAGEDKCLLATTPTAVAVATIRDSESRILEEQSLFLQTRSLHVVAEPIVGDVWMYVHITYMLNIWMSLVNESIDSGLLHMEGSVIMSTALNAYHTPPRIDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNR7</accession>
    <name>A0AA38NNR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_344963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNR7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="948" mass="103644" checksum="633A10ABF176170F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNT2</accession>
    <name>A0AA38NNT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_79172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041317708" evidence="1">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="442" mass="48778" checksum="89A4BD06D2776006" modified="2024-01-24" version="1">MIAAAGYLVIGLLSAAMAIPLSGNIPGDLPTDVHSLNSNQAQGLSRRAGWNLFGGSQAQKESSNTRTSMPWKFEFIKGEEGGVLDPAPEGGLANPPAINIVGELLREYSLQKHGTLPRIEAKNHFPYYGIETVYFKVTGPPACKTNCYGYVKSSDHENPMGHITQGDLRLEPKTYPIWTYIPEQPETSTQWTIHIDTLGEEIWLRPKKLYMEYVISVFLREFWLKQPGNLDMSKNHAGMPAFVFEKYLIDDLPETRTTLFKVSGPAECKPTCFGELDTIDAANPSGNTWGILKLPSKVVYDNSDQVQKPTRTTQNTVHPSPLSGFGQKPLASSFDRYTATDCLNTFFKPDSVRLALGAVPGSSFDIAHIYTWPMAEETRPKRFLIHFVLRSDHCGGECTGVVSMSGIAGNICNVHGQIIYKTDGTKGAHIPVPPDCRVHYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPE4</accession>
    <name>A0AA38NPE4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">chitin deacetylase</fullName>
            <ecNumber evidence="12">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_271464</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="12"/>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPE4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041425563" description="chitin deacetylase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="16">
        <location>
            <begin position="129"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="349"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3784460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="415" mass="45318" checksum="12786D975AB23533" modified="2024-01-24" version="1">MAFLVVSILHLRVNAQSTTADRTSEVGEAAITDPNEECSPYSYPPVDNQLSSFPAIWEAASILPNDSTAQGKWNSISASIPSNISVKVTQPPASNYSSNDPDCWWTYSLCTEPKLSGLSADITAAPEPSTLGYGFDDGPNCSHNAFYDFLQSQNQKATFYYIGSNVADWPLEAQRALADGHEICARKWLDSLFITLSEFQTLDRYVMQMIKLAVGVTPTCWRPPYGDVDDRIRSIAHALGLQTIMWEYDSLDSDINGNSITDQTVDTSYNNFIQTANNGTFNYTGAIFLTHELNNFTMSEAVKFYPQFKSSFQHIVPVGVSLNKTQPYVETNYSLPTFEQYISGTVTVNGTRVSPNSTSSSESSTSSDSLSSTSSATVSGNGLPTASSSNAADRLTDTGHHSILPSILFLISYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ80</accession>
    <name>A0AA38NQ80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 3'-terminal-phosphate cyclase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_409774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, RPTC, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="9">
        <location>
            <begin position="188"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="6">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="39635" checksum="4B91AFC984FF4CDC" modified="2024-01-24" version="1">MNISINGSLLEGGGQILRNSVTLSALSGKAIHIHQIRNGRKPPGLKNQHRTGLQLAAEIASAKLTGATNGSTEIEFTPGALKTPGDFVADSVTAGSTTLLLQIALPLLLFASQPSKTPSRLTLKGGTNATHAPQIDYTENVFLPFVRRFFGITTELQVNRRGYYPKGGGEVLFSVTPLSQCLKSFSLLERGNVRCIKGIAHFAKLPGHIGPSMLDGAKKVLSARLAGDSSSSIPIEIQSRRERNDNTVGAGSGVVLWAELEGGGIIGGSAVGTKGIDASLLGEKAAQDLLRGLDAGGCVDEWLEDQIIIFMALAEGDSAILCGKGELQLHTRTAIWVAEQLTEARFNTEQLESGHTIIRCKGIGYRPSASSNMPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQA7</accession>
    <name>A0AA38NQA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome biogenesis protein BMS1/TSR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQA7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="157" mass="17631" checksum="D6464502E81F5B9A" modified="2024-01-24" version="1" fragment="single">MFESHCLRCQLSSYYTYDPAYPLLLGGLLPAESHSSEPSSFNFVQVRLKRHRWFTRPLKTNDPLIVSLGWRRFQTIPIYSLDDHSIRVRMLKYTPEHMHCYGTFRGPGVLPNTGFCAFNTAADGAETGGFRISATGVVLSLVSTSQIEIDGNAVQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQJ1</accession>
    <name>A0AA38NQJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_406358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="361" mass="39570" checksum="E5D87806DB76A943" modified="2024-01-24" version="1" fragment="single">HSEHTIANLRAELQHVNHHLAKVEKACNTAEVNLSLQNAQHKREVSQLNQEVETLKSRPDLEGVVAELEERINEMEDLLKKKCEEIEENDDVKLGLMKENKNLKTKVESLTRKVNNLQTKLAAAKATLPVPTTVQQHIPSSSSTISASTSSSSSSPPNSVPTSASTSRPRSNTMVGTTGSFVPPDNVSPPTVPGKLNRVVSVPSALPRPKTPERRTVLGPVFKAMSPKKDKPKPEPSSAQSKKRRAPDDFEGYEIPPQAFTAESLPGDGEHVSEHTTPKVRRVLSSIQSGFTPTRHQNRPMIPMPSPKRSNPVFMKSPPNVPEFSDRALLSSVEQPVDGKKRSWLGKIRGASSTAVQRDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQU1</accession>
    <name>A0AA38NQU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATPase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9545" checksum="5D813710BBE2116F" modified="2024-01-24" version="1">MFSRLAVRRAPRSATMSVRYTSSIKEGSVAQSRGFKDRESAVESEYVHKQEQAYLKKLKAEIEFRKIELEKLEKIHAEAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRI9</accession>
    <name>A0AA38NRI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_26375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF162">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="398" mass="43976" checksum="D93B00AA6755E6FE" modified="2024-01-24" version="1">MFYYVSFLRPPPLQALPSSSVNIVPQIANDLRTELFGDSLDIFYSWYPAGETDENSIDTAKPVRLTTWKHTNAYKEINVPLPPGVRDGQTWRLILSSEPQHISINFQDACGPEPKFGKTPFAVISMPINFTKHATKNSKKQEKIERRYSFIAPRLQNSENSRVKLTLKIIEQTSFDLDKKIWDSGIGLSSWLVSLAGNVDSSVQESDSAVAQLRRALFSPAARNIIELGAGTGIVALTLGALRSVLVADEGEPDDGCLITTDLPSAMPLLEQNIYLNSHSLTRETSCPRPEILDWNADIPPYTQALRGKLDAIIMADVTYNTASFPALIRTLSRLIKLNPIDKPPMILLGYKERDVAERTLWTMATEIGVLFELAGEKPGAGGAPVEVWIGQIGQQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRX6</accession>
    <name>A0AA38NRX6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_341966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3790008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1258"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1623"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1733"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1360"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1825"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
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    </feature>
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        <location>
            <begin position="1367"/>
            <end position="1392"/>
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        <location>
            <begin position="1412"/>
            <end position="1424"/>
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        <location>
            <begin position="1463"/>
            <end position="1484"/>
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        <location>
            <begin position="1488"/>
            <end position="1500"/>
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        <location>
            <begin position="1527"/>
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        <location>
            <begin position="1554"/>
            <end position="1566"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00010937"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ3790008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1850" mass="206844" checksum="AAFE1246B2265BF8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSA3</accession>
    <name>A0AA38NSA3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_249671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="DUF3292"/>
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        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
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        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="647" mass="69969" checksum="828F697770BDA0EC" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTH0</accession>
    <name>A0AA38NTH0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate esterase family 9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_339563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTH0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="385"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="927" mass="101177" checksum="CDCE6337EA7B3F86" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTJ9</accession>
    <name>A0AA38NTJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_338994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTJ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="34520" checksum="E61E17CB1930D055" modified="2024-01-24" version="1">MFCRAGKNLTRAVGRRTFTQSATRKSYDDTIRNLSIHKDTKVLVQGFTGKTGTFHAKEALAYGTRMVGGVSPKKAGQTHLGLPVFGSVREAVRETSPDATVLYVPPPTAADAIIEAIENEIGLIVCITEGIPQADEIRVTQALKSQSKSRLVGPNCPGIINPLGCKMGIQPGHIHKPGNIGIVSRSGTLTYEAVAQTTDVGLGQSLCIGIGGDPFPGTQHVDCIKVFMEDPSTKGIVIIGEIGGSMEEEAADYLEKYNKTLAHPKPVVGFIAGRTAPPGRRMGHAGAIISGGKGAASDKVAALSKAGVIVTDSPAKIGAEMLKAMKAAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU34</accession>
    <name>A0AA38NU34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU34"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="453" mass="50201" checksum="9ECEFFDFE25887DB" modified="2024-01-24" version="1">MPEYSFKFERLVRPGDSLFEAQDDLCCKSPLRSPVSTGNVSITKPSESVLKAAASGLKYLYFGEGFMNRLQGYSDDTFKIPGLRNVFRASDLPLSRNLPPTKQVIQALAGIARKEQELHFHKPLPLTNKSSVLHEAHVQIFDYLNLLIKIKEVNTALLTPNIPIDTSTKTVTRSFYDTRGREVDRNKLESVVFTPYWGQNSSSHLEDLNLLGVGQSGPKPGSADFTLFRNPSLGRANQPGCAEVKSPWNYSTRDMIQIYRGHPNVIDEHNMFRFTRSKRAANLMLEQVYGELAALASDIGFFTNMDIVFFYLIFDGGNAEGVVHKATEQQKDPQHHKKSVTVGLKGIQLDGLMQFPDGRVTQQGEVGLDLAESGPATRSRTNANTDEQVGDSNSGLILSPVLNFEDPRVLKCLQGLTYLALDREKWRAAGKSLVDILAPIDELSLITQAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYZ4</accession>
    <name>A0AA38TYZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_383804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="296" mass="33471" checksum="F87FA7E994BA75EC" modified="2024-01-24" version="1">MSRNIREEPPQRPKTAPLQSEQSGSSVSGAFFAGAHNFDVNGGAFHNAAGDINSTVHNDHSAKSDFNNDYRGAARYNGAHNDYKGSSHYNGAHNDYKGSTNYNGAHNDFQRSLATNLDDRIKGRLHPPYPGPYAPHINNNGFNDQNARLEDAPRREKPELYSKFEDELVDERERPEVKYDYMEGFMQTRRESHEDFQFQHELGSNRKTSNGESQRPATPEEEPGAAQLRQCVEKFLATRFPGKGLSDLADTLINAGWDRETLAQSEWGDIKDVYKGPGWTSPTFVRLRTICKQWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZD0</accession>
    <name>A0AA38TZD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_303785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZD0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="366" mass="43733" checksum="275F96A8DAF80079" modified="2024-01-24" version="1">MFKDLQRKIKEDHVEFGGEYTIPFDPLISDRERVQFTIRIYTWAVKRMYTFCVGHDLRELWAYLWENWYRPARWKLWTRAPSPEIPRLRTTMINESHWRHIKHDFLHYFHRPRVDLLVWILVAKLTPTYQRKLDNLTLDIGRYRGLAGWRKAFKQEWKKLERRPITLPLNPGYRPRVKQWACTCPSQAPNRFLLCKHLVQGVEPVPDIFFLEVTRLCTAPFWQHPSLIPKTDLPEGYVDRDFIQADIPDDQQLDPQQNEPEDGNESDGEEEEYEYAILEDASATYDERMDELIGKLRSFADGLHYQKQFRDVRFLNTLEKHGSGFFRMLDSCLDKERRQNHNGGAPTRTWDPKAASAMFYRTQPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZT9</accession>
    <name>A0AA38TZT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_258691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZT9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="409" mass="44261" checksum="07CC5190ABF93572" modified="2024-01-24" version="1">MSQAKISDAAKAKVAEEIKFDILAGVPELEGDNELKRSQIARTFISDTITVPTKEMYSYALLASLGDDVYHEPSTAQHAEQAYSALEAHIANITGKEAGLFMPSGTMSNQIGLRTHLMQPPYTILCDNRAHIYKYEVGGAGFHSGAALTPVAPSNGHHLTLKDVEANIVYGPDVHFAPTEVIALENTLNGTIFPQDDIIAISQFARSKGIKMHLDGARIWHVAAETGMSLKELLEPFDTASLCFSKGLGAPIGSCLVGSKEYITRARRIRKLFGGGMRQTGFLAGSAAYALTYNFPLLPRVHALASKLQKSFEDIGVTILSPAETCMVFYDASSIGSNYDEIAERGAALPEPLFLGGSRVVLHIQTSEAAVDDFINLLATIAEEKRKAGFVKPETQVNGHPDVYVRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0N3</accession>
    <name>A0AA38U0N3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_257915</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0N3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="855"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="1002"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="149"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="285"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="960"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3790737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1107" mass="125023" checksum="05685F5928394E99" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U143</accession>
    <name>A0AA38U143_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_339282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U143"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1051"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="878"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="804"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="925"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="961"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1143" mass="124613" checksum="E8DC0310484900DC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1K3</accession>
    <name>A0AA38U1K3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_65842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1K3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3791114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="250" mass="27576" checksum="3EBEB08D3A7646AE" modified="2024-01-24" version="1">MNSSKGQYSSSNQWSGQQHRSGSGNYPSSSSYDQADQHYGTGDPNVNHVAGYYTAGHEGYLSGDTSSSSVNPHHYRYSQSIAPSPHTQMPGQSQYYSSHHRSPEHSPSSAGPITHSHGHSHHHSVSHPYGQSYMQSGSYPTQGRSRSHSHSQMVQYDPVSMAPPSQYPPQVPIPPSTSMTYTATPSRPFACDLCSLSFNRQHDLKRHRETHTGEKPYLCNGGCGKTFTRKDALKRHQLVKGCGKVDETWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U565</accession>
    <name>A0AA38U565_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U565"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22669" checksum="EA14AC8363263E60" modified="2024-01-24" version="1">MSTISEDDGTHSIIGTLPPIPTNSSISPVATTTNQVSLSTFSSYSEPTVSPTNNINSLSSISIHEEKQWKVIGIGLIVIAFIASMILLTVFFEAWWGFLRDLCGGKEYRGGVEEMVPDSEDKKWQLNLSNEDGHRYPSASSMESIINQTHKPKSPYPYISTPKPLFQPPSYFRPHYDPHPLEPLFRRPSIKTAVIKSPIQSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U5Z6</accession>
    <name>A0AA38U5Z6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_383944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U5Z6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041373336" evidence="4">
        <location>
            <begin position="20"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="47"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="532" mass="56905" checksum="51D0D226A349F538" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U8K8</accession>
    <name>A0AA38U8K8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U8K8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3791220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="334" mass="37394" checksum="C824BEA3A918E964" modified="2024-01-24" version="1">MLTLLRRSYGSRPRLLTRSFAEVVPVTSQPSAPQPLKGTIDPPPTHAIASPDGNNSASNAEPKIVAPVRLGNRVPVRADHGLYAFFRLKEPAAGQTLKGEAQYETLGGTIEMDRTRSSRAWKASELRLKSFEDLHTLWYILLRERNLLATQEEEVRRLGATKVVLAFNTQVRACRKSMARIKYVMNERRLAYEGALKLAEEEKTAHITNLVLKQQLAEHQKERELFRRQKRARIRAAREAKRKAEQARKEIHVAEVQSSVKEQDIVTAEPDSIDKKIDAPEATAQHPQSIKTGTAQSAQTIEKPEQTPKARSSPVESASEAATAGLFGTRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7Q4</accession>
    <name>A0AA38K7Q4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_369090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793692">
        <property type="protein sequence ID" value="KAJ3780594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7Q4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="103" mass="11388" checksum="55F123714B4C855C" modified="2024-01-24" version="1">MTEGCAIVAPDDFIHSVLGDDGKETTIALIRFQELVVRGFIASSQKLKFCPNFVLSTLVPIASCGGRGVLGSGTNKIRRRIRPRPRQRQQQQQRLLRESSPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8Y0</accession>
    <name>A0AA38K8Y0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_60923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793436">
        <property type="protein sequence ID" value="KAJ3783099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8Y0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041375845" evidence="1">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="194" mass="21934" checksum="1269F18F320DB310" modified="2024-01-24" version="1">MSLIPLSFSPRLALCFLFLAIFHAVASTPVSLPASTRKISDLEIVLVRKDGNGKYIETTSSNIRQGQITPDDQWEICIHIWCFSARNNAENADKFAYPGTPGKNLKELGLFIGSISFSSLAQREEIFEYMTSNTFYAGTTNNLEYLNSLFDYISKLQRDPSAKNVRVGIMRSKKDKTKKNLWETCYEAIKAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9N8</accession>
    <name>A0AA38K9N8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_271062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793369">
        <property type="protein sequence ID" value="KAJ3784629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9N8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="171" mass="19311" checksum="39902DF1BCE0892E" modified="2024-01-24" version="1" fragment="single">MRNTYARSVIKYLRNSKGAASVFAWPTHPARLGIYETSVQHRFGDPLAERLGYILTRNAPYNGELGETEEIGSDERFLAYRISDHAHLILDSAYEDGEHEIPTRVLENPDFEPSTWFARRLQMTGGGEAVASSPSRPMGDARAKRLCEILNNAEAFPGDDLPDFHPRRSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB35</accession>
    <name>A0AA38KB35_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_149373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB35"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041214926" description="LysM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="160" mass="15777" checksum="84D7B838B0420D44" modified="2024-01-24" version="1">MFARLSLFTMVTVLGAVGAIVIPRESDASCTAGVGTPITTVLGDTCETLVSQLGVALADLQQLNPGLDCSSLVGGQQICVPDSADGILPTGILPTGILPTGILPTGILPTGILPTGILPTGILPTGILPTGILPTGILPTGILPTGILPTGILPTGILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBJ0</accession>
    <name>A0AA38KBJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_287323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBJ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="191" mass="21406" checksum="36463A02C2F7B9F2" modified="2024-01-24" version="1" fragment="single">MPSPSPITYRLYTGEPDLPHIISLIASELSEPYVIYTFRYFLTQWPHLSFLAYTPESPTPIGVIVCKQSFHESSTRAYIAMLSVDKRYRKRGIASTLVKISMEAMKLDGVEEISLETEHDNAPALSLYESLGFIREKRLYRFYLNGKDAFRLVLGVPVSELEDEKGDGDGDTLSVSSPSIVDGDGDDEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBK6</accession>
    <name>A0AA38KBK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_417412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793804">
        <property type="protein sequence ID" value="KAJ3780298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="586" mass="63700" checksum="B0B5D09109B1B375" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBM6</accession>
    <name>A0AA38KBM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_307822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBM6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="753" mass="81660" checksum="6804312AB39E4A41" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCL4</accession>
    <name>A0AA38KCL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793499">
        <property type="protein sequence ID" value="KAJ3782098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="273" mass="30515" checksum="28D72691A387AE1D" modified="2024-01-24" version="1">MFNLSSPQSSRKFIDLIFAASSKWANWDPPKQIHVGDYGTIDKKTGEFEKEGNIYEDVTTAEIATAHPPQTAAKDKTFEISSNHVRRTEFSLEPTASIPGIAEASIKGEWRFSSKRGALLVMNQPRSTYIPPKALLKKLVDVPELKDKYLATETFSCPAYSLYLSSGEDEAVRLALLATVPLPTAVPLSVGGSIQSSWWNQNTSGLFRCASDNEYSYTPLYTLKRIRKPGLLRRDSPLPSADDDDDLWEDVAQPWDPLDSDGEEQEFEDEVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDG8</accession>
    <name>A0AA38KDG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="4">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HCR1</name>
        <name evidence="6" type="ORF">GGU10DRAFT_321282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793656">
        <property type="protein sequence ID" value="KAJ3780776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="253" mass="27855" checksum="ED95476FC78712E7" modified="2024-01-24" version="1">MSDWEQSDDEKVASPPPKVVPVKSKGKWEGEDEDDEAPASDWEDSSEEEEVKPASTVTTAPPKKKGTLKAKLAEKEAIKASQKDDDDDAYDSDAVLDPREKARRLKEKELNSDLNNAADLFGAAALGGTSSKELDSLLSFQPRTKEDFVELSSMIIELVIKRHQNKPLYPLFVEHHARELAGPLKDVEVRKAASGLTTLANEKQKDARDKVSGKKKKAVSKPTLGSVKVSSKFDTGVYDEALDDFGNHPDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDI7</accession>
    <name>A0AA38KDI7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_126892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793629">
        <property type="protein sequence ID" value="KAJ3780926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDI7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="479" mass="53670" checksum="45EC23769F328E93" modified="2024-01-24" version="1">MSLKRGADSSPARSSKRRQILFPSVSNPVTPAKTPSSVYLFPSSPSTPYPLYPSDSPSNPFGRTRTLSASLPPKSSFGRHLPLRFQFFRHGMKRDREGVYRVVQVPLSYNLKHVKTLIAFLFGGQPEKSPDEEDEKTGHLFEIRKNVVMYSNLYKPGTIKRSETSVRLSSARDPYRFKQEWDYGEDWRDDNDDDDDFDEREEDQLSEDSEDGKEEARWEAEEDYTLGHVWKPALGGEVPDAKTAIVYFHSSLSDTECPIQVQITLHKGTIPSRTGAGNSPYVFEARGHVYLSPLDHDELDPEEDYDEDLEMDIDPAAWNEPTNAFAKFLIESAGIPLPDFSQSKGLSANSTPSLVHDFSSPSRITDPFPSSPYLSSSSPVRAAYSKSSPLAFSASFPQYTPAPPPAQRKRVAYIQKRIERSKRKNLAKPDNCSDGEEDSKPNSTTTVEKPSGPRGIDGRYLTRKEAMRIIGADDNVAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDS4</accession>
    <name>A0AA38KDS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_277568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793560">
        <property type="protein sequence ID" value="KAJ3781421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="60" mass="7227" checksum="9518735FB32867C7" modified="2024-01-24" version="1">MARVGDVTRIWEINIHWPMYSQCSVWDGKGVEIWECLVDHLSKPNTRPPNPVYWRYLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE52</accession>
    <name>A0AA38KE52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_21084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE52"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="164"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="353" mass="39203" checksum="D0D4A9A4C00684FA" modified="2024-01-24" version="1">MATIIKVSANAPLVAPPSFVLTGAWINLLFYSVEFLVGSYYFFKVPQRKIKALVAVALLLDTVGTISTCQYTWVALITPNKTVKAVAEPFLLASTMSSLSAFIEQSYFAHRVWTITQSRLIISILCALIVIPMACVLASIALALKLDPAVDQSDMATLNIFLGVITDVVIAVYLVYKLRSINLIQFSCSTNLIRKITAYTVACGCITACFTIVTTTLTFVSVGPFMIFFACNGRVYTLTILANFLLFHEWRRDYDEKRRSSHNDNDNQNTYLRWKDSTWSRRFTTSLSNTSTPSPRYPPSALKHSRTSVSVVRMEIHGAAQGAVHETFQKPVPGPPFSIESIFSKSEEDLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEP2</accession>
    <name>A0AA38KEP2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_274335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793439">
        <property type="protein sequence ID" value="KAJ3783041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEP2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="29930" checksum="B230EC7A442F71A1" modified="2024-01-24" version="1" fragment="single">IGDFGSCTVPQIQFATGFDNRKETSFEPVDQTSYPHGSAQNIDIITQAMCDQLVNTCGADATAKATCAAAQSAADTATAKTGAQADKFNAVFGIQTNFAAVPVVSDQGVTLGVGKSATDAASTSAAATDAASTSVAATATAAASSSAVAATSTASAADIGNFGSCTVPQIQFGVGFDSRRETAFEPVDQTSYNHGSADNIAVITQFMCDTLTNTCGADATAKATCATAQTAAAAGLAQTGDQADKFNAVFGIITQFAQVPVVSNTGVTLGGTSIHLLSRTSFSYSPSVDGTNTAAAATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEV8</accession>
    <name>A0AA38KEV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_361440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793429">
        <property type="protein sequence ID" value="KAJ3783236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="138"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="669" mass="77283" checksum="D3B5276665DA22AA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGI7</accession>
    <name>A0AA38KGI7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial protein Pet127-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_115019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGI7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="769" mass="86594" checksum="307E4E0CA1BC52B2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KK72</accession>
    <name>A0AA38KK72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mate-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_397920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794256">
        <property type="protein sequence ID" value="KAJ3779759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KK72"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="388" mass="41699" checksum="3B6006153FE5CFF4" modified="2024-01-24" version="1">MTANVTSFSIVIGMGGALDTVLPGVWGAILYFFLLIPMLCIWLHAEGILVLLRQDKDVARLAGKYLAMFAFGLPAFSFIIIAKRYFQEQGLFSVPTKIGTIVAGVNVLLTAILGFDGAPLATSISYNLVALGSIFWGWKIESEMRSAWHPLSMRALHPTGLGTLLTLGLGGVGQTASEWWAWELVGLAASLLGPTALAAQSVLLVSCSDTYQVPFALGIATSVRIGQLLELGRPRLAKLAAHAAILLGLVLALVFSAIFWIWRKKWAYLFNDDEDVATMVAAILPLVALFQVFDGNAAITATAGLRGLWTGLTVSLVLYCAVLGTILCLATNWEHEVAKVKARLRANPALLDAVESAGCLRGAQHESRGGRMGRNHCRLGFRSTYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKW9</accession>
    <name>A0AA38KKW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_368362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793635">
        <property type="protein sequence ID" value="KAJ3780884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="407" mass="44301" checksum="4A22FDB1AFD90D55" modified="2024-01-24" version="1">MDSPSWTDVFHSAFSSCLHCFQAPSNDSDSDSIQRPPRYLESLLTEPLLDTDTEAETVSLHSNVGDNCQRRKKKQNKRITFFGFDLFGKRSTGPIHLPEDDEEVDGLLRRPRRQRQRPTRISSSSSPSTITFDGNVSDAAPLDSAAISERVIEEEETRAAKEREKDERRRKRKQRKEMKKFAQVLMQNGGEGEFEGFQGSGGSYPHIPSPFQPGFLPSPNLDDFGPFHQAIHVAQGDEDDAADLDGSLYAARKPNEGGSSISGGGSDSRRSPGGTSTSRSDYSDPRFLSMTGNFQPSQPKTKSKKSKSPVSTSSSSKTKSTKSRSSASATSSEQTESLASPASLNSLNSPSLTENKPILEFQSSGLPKPGFGKFGDFERSFPSPGLEFNGAPRNGVARGGAFLASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL12</accession>
    <name>A0AA38KL12_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_278322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793614">
        <property type="protein sequence ID" value="KAJ3781019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="142" mass="16334" checksum="4D1A115A5DE22E36" modified="2024-01-24" version="1">MSGLKKGWAQTFSNSPRSQKFLAIDKKGVNSKFVKIAGELKRKQTSILFQLRSGHAPLNHHLHRLKKAGSPNCPRCDHHFLLECPAYRRERFHLRRKIGQAAYSLQQLLSEEKIIPHTLKYIGETKRFQATFGDVSPEINNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLI0</accession>
    <name>A0AA38KLI0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_365912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793533">
        <property type="protein sequence ID" value="KAJ3781679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLI0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001692">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.18, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="224" mass="25332" checksum="F4667B52CBE1C194" modified="2024-01-24" version="1">MYHLLKGLHEHLTRKEEFSIIIIGLDGAGKTTLLEKIKTFYNDTPGLSPDKIGPTVGQNTGKITLPSTILQFWDLGGQRGIRNIWHKYYDDCHAVVYVIDADDRERLSEGWEVFDSVLSAPQILGVPLLLLANKQDTPHSLSVEEIRNDYENYHQRKMESARRSVRYGEGEDMTSRKERIASLDVMGVSAIEGTGVRAAVDWLFIRVQNSRRDSQKNSNASNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLN3</accession>
    <name>A0AA38KLN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793516">
        <property type="protein sequence ID" value="KAJ3781889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041344306" evidence="1">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="135" mass="15358" checksum="D6593728874A974D" modified="2024-01-24" version="1">MLPRLSSHRIVCACLFLVTSLLVTVVASPLIAMTDRLEHQTLAKRDSQWKKVIRIGFQKPGSDTYESAHEIRSRGYSGLELTIFFGSRGFKPRIVTPKGYINNIPPKWEIVKVDAPRRQTRNGAYWIWGLSITSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLU9</accession>
    <name>A0AA38KLU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_364521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793496">
        <property type="protein sequence ID" value="KAJ3782144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLU9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276:SF0">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="172" mass="18592" checksum="001190CDD484903B" modified="2024-01-24" version="1">MALEPSSQLPAGLLEALQASSSRSRPTPYLLSSFVNGISDVTETTDGETANKYDLLCPRPGCGSIILKKGVAVLEERESFQIEPSDIPPHPLLPPLPDTSESIRWWLITPSPMSFENIGFSRPVESLPLSPAGKKFKLLACAECDLGPLGWSEEGGTEFWLACSRVGYQSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM24</accession>
    <name>A0AA38KM24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxisomal dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_297778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793471">
        <property type="protein sequence ID" value="KAJ3782519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="181"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="316" mass="33864" checksum="AD7BC1AFF2E29F5E" modified="2024-01-24" version="1">MAAEISKLIGYELPDRPVSWLKRDLILYALGIGAKDASDDLSFIYELDPNFASFPTFPVVLTFKGDSQEVNLFAETMKSSALPGLPPVDLGKSVHGSQSIEILKPLPLASGPGWKWKTKYTGVSENKSGVVITNENLLVDSQGVPHARLYSSSFNIGMKITGEKFAKVIAGPPQAKSIPKDRKADWVVRQQTSPDQALLYRLSGDYNPLHIDPQVGRAAGFGGTILHGLATFGFAARALLNAIAYNEPESLKLFGVRFTSPVKPGDVLETHAWEVGPGPDGTIEVAFVTKNLTSGKDALGGGIAYIIKAQAILAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM95</accession>
    <name>A0AA38KM95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_91436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793509">
        <property type="protein sequence ID" value="KAJ3781980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM95"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="295" mass="33554" checksum="8DD8772B016DFE10" modified="2024-01-24" version="1">MQTPIRERVGGYSDFFSSGFRAISLNDSPSRPRKSSLYSLSSIPSDLIHSIPSTSRRRSIVDDNRRRKPMSWSLKRREESHTNLSTSEKRKKRSSFIEFSAGLFEKMNPGVLQPRSFVDFDNNQKRLRLHSRNGSSGREKLGMSGLIGTHVSSIQTCYPDANERDPFNPSPHSESFFIDLSDSSSFSSSPKRSRHQSFISFSGASVSTLNRFTRRERPASIHSLPTSDLLSSRPIKTKHPFSRSPSYQHPANLDKADSILQEKASSDPESPYEHGNRDLADIDWREFHIQLYDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMV1</accession>
    <name>A0AA38KMV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_274955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793457">
        <property type="protein sequence ID" value="KAJ3782730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="201" mass="22466" checksum="870DA8D8FBEDBE9B" modified="2024-01-24" version="1">MECILYGVYLVSLGYCLRALLLEPFEQGLQRKKHINWVMLMVALLLCLFATLNVAFGLRHNLDAFSYYHGPGGATEELNDISYWVNVMKTADYVAQTFIGDGMLIYRCYIVYGKNWKIIIPSIFFWLGGSVCGVFLTYTFVTLKSPALIDNSKAVPYVDTMAALSLTMNTLTTGKDTCFNQCCCLLINPHIALIVGPVKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMY6</accession>
    <name>A0AA38KMY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_70008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793449">
        <property type="protein sequence ID" value="KAJ3782865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041449371" description="Hydrophobin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18087" checksum="9D4BA718F48347BA" modified="2024-01-24" version="1">MKKLFVPLHFMLLLPCTLEFEPAKQTIVNLFGPSKSLWSQYCLPLGQGWKNPSRPKSTSFLLVIRLLEASFNAISCTQSSDFGPCCVPNTLKRPWKKQRTMLTDYGGTEIASALSLVYSSLPKPFSPSQSSSSHTEAPGMSPPASHILKPRFLLFLTQPRTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN96</accession>
    <name>A0AA38KN96_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_236564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793711">
        <property type="protein sequence ID" value="KAJ3780531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN96"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="58" mass="6712" checksum="0C722AE7C4B15A55" modified="2024-01-24" version="1" fragment="single">RRYVCTAPGCGKCFVRGEHLKRHVRSLHLSEKPHKCPYPGCNKSFSRRDNLGQHARVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNE5</accession>
    <name>A0AA38KNE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_389178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="90"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="192"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="330" mass="36217" checksum="FAC5FFFC1EDD5583" modified="2024-01-24" version="1">MSSFDNTHITALTDLINKAVQDIIAEYASAGRAVPSLDTLESGLFQVPEETPARLTKAIQIVEAACAQLSCTVAPPGSVMINKSLEHEEPACLLVVTEARIADLLLDKPQGLPASELASRSGLDTRKLTRILRLLATKHCFKEVKPGVFANNRLSMKLLSSDTVSSIVCLLTDESLRASAYLNETLTDPSERDGGIPFIRATGYPFFDYHKTRQGLKKGERFPRAMVGWGDVTGKGLLAKVYPWTSQPANTTICDVGGGNGHVTMNLMKAHPHVKVVVQDQPQVIEMAQKFWAKECPGAMEKERVQFVPFDFFKDAAVQGCDFYYIRSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNM5</accession>
    <name>A0AA38KNM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_360629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793416">
        <property type="protein sequence ID" value="KAJ3783495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNM5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="60897" checksum="40413510E3674A35" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPG6</accession>
    <name>A0AA38KPG6_9AGAR</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_271573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ZnF_GATA"/>
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        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="AreA_GATA"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_9"/>
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        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="Sec7_C_sf"/>
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        <property type="entry name" value="Sec7_dom"/>
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        <property type="entry name" value="Sec7_dom_sf"/>
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        <property type="entry name" value="Znf_GATA"/>
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        <property type="entry name" value="Znf_NHR/GATA"/>
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        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
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        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GATA_AreA"/>
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        <property type="entry name" value="PH_9"/>
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        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GATAZNFINGER"/>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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        <property type="entry name" value="PH domain-like"/>
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        <property type="match status" value="1"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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        <location>
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            <end position="2036"/>
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            <begin position="217"/>
            <end position="233"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="461"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="1174"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2025"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50114"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784395.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2036" mass="218045" checksum="804E7D9893285035" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ44</accession>
    <name>A0AA38KQ44_9AGAR</name>
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        <submittedName>
            <fullName evidence="7">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Lentinula aff. detonsa</name>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ44"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="36599" checksum="E3FBBDE8A04D4290" modified="2024-01-24" version="1">MYVSRPGQVGSSDTRSSSPFPDDASDGASSSQSTIVQLTENFRLNPDLGEFVSTIYSKAFRPQKVQARRIALALSSIPQSKTSQATSEYLKILDFAQRFLLGLSHIMLKRPQRDLSPPLLSNLKEHTHSNDLYSSDVAPHPLSLALIQLYTISRKHRDNVGYELHVKAEAAVTAALIAVIQEYLPGEDIFVATPHRIQRQAVRAALLAQHFETLSELFDEMTLDGGKKKSTVTVDTIERLQGSEAAFVICLFSLPQSHITDLQFLLERRRLNVAISRAKSMCILISSNEVLRPAVGVLTDGETAKGYTFLRAFADRAWSSNVSVDIDALNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQF6</accession>
    <name>A0AA38KQF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_361645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793433">
        <property type="protein sequence ID" value="KAJ3783171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041254939" evidence="3">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ThuA-like" evidence="4">
        <location>
            <begin position="29"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="327" mass="35382" checksum="484A590C891A2D76" modified="2024-01-24" version="1">MLDNANTFRPITLLLLSTLVASSLATNARVLIYSATADFRHDSIPTAIQALQSKQSSFGIQFENTEDKAQFTDQILAQYDALLFLDNTGEVLDDSGKAAFQKYLNLGGNYIGIHAASDCLRNTTFYGNEVGAFFDYHPALQNATVDVIDASHPSTSMLPAQWHVQDEMYNFKTDPRAIGATVILSANESSYVDTGTHLGQGTPHPTAWFQEHGAGVEGNGSSGRSFYTSLGHLNETWQDELFLAHVFGGITWTLQSNTTLAFNASAQVGNPLASTSNSTSSSSTSILPTPSSSSSAMIFCPSIDKFSIEFMIVSVIVAACFPWLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQM3</accession>
    <name>A0AA38KQM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_434341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQM3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041317873" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="14600" checksum="E4D7ACDA607B1F73" modified="2024-01-24" version="1">MQFTLLASALMALAASAVSASPVSNKARMILDVWAPTIISPNASTVWTEGQQYNVTWDTSNAPVNISNGAAVVLGKDGKLTNTTLVSGFDLRQGWVTVTCPSDVIPEDDYSIILFGDSGDQSEQFTITTSLEGVLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQM6</accession>
    <name>A0AA38KQM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_389126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQM6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="936" mass="102865" checksum="99F0FA21FD90898E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSC8</accession>
    <name>A0AA38KSC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_345200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSC8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="278" mass="32040" checksum="F12C8DE9964E82CC" modified="2024-01-24" version="1">MSAVTPDKERRNKKDKKLDDLNLRPVDSEKIATGNNEMDVQKKRKKVKRAEKVQDKRSDKEEVSRSAALEQPDVDTVEQEDEVSPEKKKEKKRRKISELDAEGAPTKRKKKRKREDSENADTDDTLQAEKPKEKKSRNKTGFLDPAEEPSLSAQAQKALSYAFQQFRKPSKWKFQKARQNWIIRNWVTENIPDSQIPLVLKYLSNVQGNIRENLTKTCELIISTENSNPASPSVVTERNDDRDEDEMTQLTKQAIYPMKLIRAKAMLAALKDKTECAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSF1</accession>
    <name>A0AA38KSF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="11" type="ORF">GGU10DRAFT_261678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSF1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="38"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="76"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="296" mass="32837" checksum="7445127513BE4A79" modified="2024-01-24" version="1">MGTNYVFSLQPTFTQGLILGQLSILALLVFVLKYLFMDSTKYPFETTTYHPRINSDSIMRSQKLYQATNEDGHKNEDESAEWLNLLLHQIVGTYRSKLQDDLPGAEGDEVARKRVEDYANKIRPASFLDHIVVHSVDLGSSAPRLSNGRRVPPSQSSNSPEIEFDVNYVDTVSVSLSTSYLFNYPMALFARLPVALTISLSLFRSSVTITPPLHTSPAPTLTFSISPTFTLDLTTMSLMGSRAKLANVPKLHDLIQHQVHRVLAAKGVWKVVLPGLATVEEAKQEVKNEMADAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTF6</accession>
    <name>A0AA38KTF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_157387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041347918" description="Cytochrome c oxidase assembly protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9415" checksum="1DE9AF227A31D7F8" modified="2024-01-24" version="1">MSSRAKITLGAAIVLSTLTVWGVHVQQNQEREAMFRGVLKDDERRIAKMKQRQHEFDESQRKRELYERVQAVQDSGKEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTS2</accession>
    <name>A0AA38KTS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_413640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793625">
        <property type="protein sequence ID" value="KAJ3780942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTS2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="319" mass="37525" checksum="0676EBE3F1F529FE" modified="2024-01-24" version="1">MVTGNMLRRQRFMHYDASFDRPNRNCRTHANDQLISRLKKLPLQSRLEMNKKIMDRNRARRERACNNSDEVSDVESLITIEDEEMDDIRSDPDVFAAAKPLLDAATIRELNRANKEDATKEKEARLTLGDSEWTLEPDAILTKIDATQPNPISFPPEMFFTAKHKHNFPLAFFTPKNLSFINSILHKNAHEDKNYILNISDMEKKIKGAKTGPSRDEEMTVLDWWKAYNNYYAFESSRSMSLENNPRALFFKSHFNFFVNQEDSEELYDIWRPYEAKLRQRHYELDMEFDAAMYANTWTEIKAISASRPKQYAAKENTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUA8</accession>
    <name>A0AA38KUA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerato-platanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_346615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUA8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041210962" evidence="4">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="145" mass="14716" checksum="7DC1FE56E5764FFE" modified="2024-01-24" version="1">MNFFAFFVTVVIAAFAGLATADTLQYDTAYDDANASLSTVACSDGSNGLLTKGYSTFGSLSSFPNIGAFGVIEGYNSANCGTCWQITYSSNGASTTLNVLAIDHAGEGLINVSEEAMNTLTNGNAVAFGAVTVSAVQVDASGCGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUG7</accession>
    <name>A0AA38KUG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_286120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="503"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="541" mass="60294" checksum="83B58F44883697B1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWZ9</accession>
    <name>A0AA38KWZ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_289444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWZ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="155" mass="17356" checksum="5F5A5D1771B94631" modified="2024-01-24" version="1">MVNPEVITPSDPKSPGISRSKVPPPITVPISIPISERKSPNHRVFTPFRYLTTKRNRTMSAASVEAVDGTAPNTVVGSPTASMNSSQPPIQPPSMRDTQQATHEWRDRKESESRNNRYRVIRPGVVFDVPQDPHQDKQNLRYVKTSRSTRASNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXN3</accession>
    <name>A0AA38KXN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">GGU10DRAFT_308106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="235"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="469" mass="52738" checksum="E86861057B25BE5C" modified="2024-01-24" version="1">MAEYDLSKTIIPYLDRHLSFPLLAHLVETGVFPAAEVQVAQYELAKGTNMFDYAASLFEHIHPNQEVPKEFQQKRVNAVSTYERLQQEAQAVLDVIENPDVAQALRQDKNQNLQYLKDNYNLTLDQITALYNFGKFQYSYGNYSGAADYLYHFRVLSTDPDLTISAQWGKLASDILTGKWDVALEELNSLREAIDSRTPAPFASVSSSTNNTPAVDPALSQLHSRTWLVHWSLFVYFNHPQGRALLLETFLSPTYLNTIQTSCPWILRYVAAAAIISSPTPTSKSSSAPQSSRVKNAVREVVKVIQMENYQYTDPVTAFLTQLHVEFDFEAAQKELQKAEKVVSDDFFLGDFHDEFLESARCLVSEAYCRIHQRIDIGDLSDRLNLPRDEGEKWIVNLIRETRMGQDAKIDLEKNLIQISRPPQPVYQSVIEKTRGLAIRTQALGAAIARSGAAAAQTAPQSVEPVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYN0</accession>
    <name>A0AA38KYN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High mobility group box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_231828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="78" mass="9088" checksum="ABA9EADDCB39650A" modified="2024-01-24" version="1" fragment="single">STTPQRIPRPRNAFIIFRNDLVLTRANEGKQTQSSISKEASRLWKAASPAVKQEYQLRAEQEKKEHAEKYPGYVYKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZD8</accession>
    <name>A0AA38KZD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_5195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZD8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="579" mass="63436" checksum="C336082B3B3C203F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZQ7</accession>
    <name>A0AA38KZQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_253681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793323">
        <property type="protein sequence ID" value="KAJ3786098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="86" mass="9987" checksum="0F41BF5A3437B5D9" modified="2024-01-24" version="1" fragment="single">EAIHAFVHKMLHNSPAAQQIEALWKEYEDRETPEARFVKGASGISCITLEYERALNASALQPFYNTSIPYIEHEWGKDLLEERQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0T4</accession>
    <name>A0AA38L0T4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_432127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0T4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="77275" checksum="C82DB7F26CC711B8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0V7</accession>
    <name>A0AA38L0V7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein ypt5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_82589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0V7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="258" mass="27272" checksum="627BF3B9472F3E30" modified="2024-01-24" version="1">MADAASGSTDKSVQVKLVLLGEAAVGKSSVVLRFVSDEFQPNKEPTIGAAFLTQKCRLEDRVLRYEIWDTAGQERFHSLAPMYYRNAQAAVVVYDITKASSLEKAKSWVKELQRQANPNIVIALAGNKLDLVQPSASSSGTPSSESEDEADDATATPGEAPSSSGGESESLRQVPREEAQAYATEAGLLFFETSAKTGEGIVEIFTEIAKKIPIEHILAATRGGAGRPGAAGGRAGNAQDAAVNLEENANKPKDACNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2C9</accession>
    <name>A0AA38L2C9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_365550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793524">
        <property type="protein sequence ID" value="KAJ3781792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2C9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="259" mass="28306" checksum="248E9387A6127BD8" modified="2024-01-24" version="1">MADAPRGRGGFGRGRGDRGRGRRGPRRGARKDDEKEWVPVTKLGRLVKDGKIKSMEEIYLFSLPVKEYQIVDFFLPKLKDEVMKIMPVQKQTRAGQRTRFKAFVAIGDFDGHVGLGVKCAKEVATAIRGAIILAKLSVIPVRRGYWGTALGEPHTVPSKVSGKVGSVMCRLIPAPRGTGIVAAPASKRLLELAGVQDVYTQSKGSTATMGNFLKATFAAITKTYAFLTPDLWREIPVSKLPFDEYSAHLALTSGTKKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2Q0</accession>
    <name>A0AA38L2Q0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_408727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793486">
        <property type="protein sequence ID" value="KAJ3782287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2Q0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="655" mass="74074" checksum="7B3D12E4E68E9E18" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L303</accession>
    <name>A0AA38L303_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pheromone receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_396677</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793453">
        <property type="protein sequence ID" value="KAJ3782797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L303"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3782797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="36358" checksum="4EE0B09B1CB92383" modified="2024-01-24" version="1">MANLDYPLFPIFAFFGFVLPLVPLPWHLQAWNSGTCFYIFWASLSCLNQFVNSLIWKGNVINSAPVWCEISIRITMATTVALPAASFCIVRRLYGIAAIRRSSISYAEKRRGVIIDSLICGLLPMIYLALQYIVQGHRFNIYEDIGCMPALYNTIPTYFITFSWTLLFGLGSAIYFLSLRAFAQRRLEFAQFMSTNKTLSFSRYFRLMALAMTEMMFTLPLTILLIWLSATQSPVQPWISLANTHIDFSRVDQYPSVVYNDNPLFVLGILFTRWASVACALIFFAFFGFAEEARRHYVLWYRASLRFVGIKSSDTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L310</accession>
    <name>A0AA38L310_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_336816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793636">
        <property type="protein sequence ID" value="KAJ3780880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L310"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="192" mass="21225" checksum="B93698D22C18D838" modified="2024-01-24" version="1" fragment="single">MREVLTVVYSELVTVYRGNCHWGGPYCHEHELITVLTKVLIVVDSELITVRTKGVTVSTVLLIVMNSELIIVLTEVLTVLHSELITVSTKVLIVLNSELLTVIRVVLTVMNSELITVFVKGLTVITRMLIIIDMSSSLSQLAPHCHWGGDHCPTQVVLTVMNSELITVSTKVLIVLNSKLLTVIRVVLTVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L567</accession>
    <name>A0AA38L567_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_163950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1113"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3786787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1888" mass="211350" checksum="50034D2A428F7EC8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L628</accession>
    <name>A0AA38L628_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_108073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L628"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="470" mass="52624" checksum="2FB28339FDD08973" modified="2024-01-24" version="1">MSLPAVTAHIVEPISTSNSGGPLDAAVEELSAALTQIKVIISDTTSEIAEETHTSKVDEVVTVRVRQASFCDLPSEILLAIFSYACQVGESWEALSFSLVCGQWRALMLADPNLWSNIALIVSDLFPNPTPSLSFSALLRMAKLTLLYLERSEDCMLSVTVKMPTRFRGLNANWQSYISVGAINFLQRNSHRIKHLHLRTDHGLLHAFAYEEPCLVDSGHDQPCSDTIPLPHLISLSVEYVSRHRFYFPFQRISRLKHLALGNEGLIFQKSPSQTVPSLTFPRLTRLVVSEPSSFHQFCRTMTLINALPRIKQVILKQIPRLADLSISRQQVILQETSLLKISESSDAFLSTFCRVYQFSGLKAFELDYDIAERSSASSSTAVAWTDLVCDIVYFIRRCPMIQTITVRNARESCYPRANDPGAQLVEEVVFEPQISPNVHIIGFPIDGPETEGPPTARAMMEFFRGFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L653</accession>
    <name>A0AA38L653_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_99491</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L653"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="24"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3788662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="536" mass="58392" checksum="60F547A13D05CF65" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6F7</accession>
    <name>A0AA38L6F7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_148864</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6F7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3787345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="498" mass="56989" checksum="30100E9ABA20E309" modified="2024-01-24" version="1">MYLLLCCSYFFYAGALAFYRLFFHPLHKYPGPILAALTDWYELYYNIVKGGALVTKIDNLHKLHGPVIRIGPNTLHFNERHAYHDIYTYGSALVKDPGFYFGFMAHGPQGLVSTCDPEDAKNRRSLLGPMFSRRAVLELEFTVQLKVNQLISLLKECSTSSDSGIQMAMAYRSITTDVITEYCFAESANTLTPGFDHPIQLSVRDLLKRIWIQRHFPFLNSLTSKAPQKLVRWLLPGYKSYVEMKNQYERQIDGLLKNPDSLSGTNHETIYHHLLNPKDQAPLSRKTLVDEAFTLVSAGSETVGGVCTVGTFYALKNPTIYRKLLEELCKAWPDKDIPMSYMALEKLPYLTAFIKEALRFSIGVCHPLPRIVRASTEIGGYRIPSGTVVEMSPVFLHMNPDVFPDPYTFNPDRWLTGSTSEMMLDLAPFSKGPRICIGLNLAWCELYLIFGNIFRNFKMTLLDTGSYERIDFRQSFKADYGAPYWYWEDYRVSIEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L750</accession>
    <name>A0AA38L750_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="15">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_345017</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="15"/>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L750"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041293108" description="Pheromone-processing carboxypeptidase KEX1" evidence="21">
        <location>
            <begin position="29"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="562"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3788935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="619" mass="69388" checksum="466DF267ACE0CB7B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND47</accession>
    <name>A0AA38ND47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_268066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7729" evidence="1">
        <location>
            <begin position="70"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="312" mass="32945" checksum="23D8112E5E9676F4" modified="2024-01-24" version="1">MTSEKVFRRQETTDVSVSIATGTATATELATPTSTAAVSASDSATATTTVPATAQTLPTIPTSTPVLPIPFPQPWDSSITQNFSSQSCYNFFLNMTNSQDFRSCRPFGLLQNTSDDFADFQTNLTALNAVIWGTCNPTPGIDQCALNMAKFASSLQSACAEDLTDNNLFAVSTQQALNAYSLTQNTGCLNDPSTDSYCYVKAVHNTNPSDLYFYSLISGVAISNSTTLTCSSCTKSLMSLYVNALNANGSQLTELASVYGAAQALAASACGTSYAEVSTSTQADSSNGASSIRRKVYGICLTSLMLTFLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND49</accession>
    <name>A0AA38ND49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_352833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="372" mass="40558" checksum="92164BB40837C4D6" modified="2024-01-24" version="1">MLMSVDFEDQPAIVILQNYIPQASPTVMEPEVNPLCLEKSTAPKSSCLPRLKPLIPHEHAPVTLGLLTPVEEIPDEAEATSSKAVRPLPNPNQQIDSNRARARTWATWSDDSQLILTSTIRSNVIQIIPESTNDPALVATNDSSGLIKRDRRVGSKRSSGALEMLTAHHHNVPPSKCTLRSNSSRPREGRSLTVSNSMDAEFVISVRRPAPQLPHSDPPTPSERQFFQRERANTNAAVPRRQIQNWIASANVASNAASSAEFKPAEAPSFSPRSHNAKVKALPSPPVAENAMKETQARITNQSHITRQDKGKGKAVDSIPQFISQEHYHGDDKSGYGLLTPPDSAPALDGLALSGLRGTRPRGPRPRRSTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH47</accession>
    <name>A0AA38NH47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794595">
        <property type="protein sequence ID" value="KAJ3779582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="20457" checksum="BF5E7163D45796D9" modified="2024-01-24" version="1" fragment="single">MLGIHGELLIMRVGIKNSQNVVHTRSGDKKRVHDLAKRNKYPKRPDASKDNQTNNYLSINFLNEPSTSYTPYLRKRPGDFEDAAGHAPRSYDKPDKARAVAGPRREEFDRQKKANREAITTNKMLMEEIERLKCLGQDAIDELTRRQNEATQKEAQRQAQEQANADQARIAQEKAQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHZ6</accession>
    <name>A0AA38NHZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_363939</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793478">
        <property type="protein sequence ID" value="KAJ3782402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHZ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3782402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="13875" checksum="0901217B961E49A8" modified="2024-01-24" version="1">MSAPYRQDMPPPGGFEAVKYKRNLPFRGPGAVVILGGVAAISAFGFYRYGQGALEKRELQREKAWSRIHLVPLLMAEGDRDAYRRQQAALAREKEIMKDVEGWETGKSIYNNPKYASPQFVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI23</accession>
    <name>A0AA38NI23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_275046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793459">
        <property type="protein sequence ID" value="KAJ3782702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="44067" checksum="EE804B894643E286" modified="2024-01-24" version="1">MYMFCWQRGLREVWGYMWACWYCPQMWKLWARSSSDHILSRLRTMMGAENHFKLLKHEHLHHLVHPRLDQLSYKLIYEVTPAYFARTSLLDDDSRLGRGRRLSTYQKAFKTSFRRLSHRSLGTKHKYITNVQTWTCNCGQQKYSAFCLCKHLVQAVKEPDPRFFTEISRRRTIPIYRHPLLIAKDSAPTSASEDDLGSVTDGDDHIWSGSVAALKDGGWRELNGKTRTLLGKRRTEDNLDEEQVSSVGPIEDDYDAAEQEAMLDEQVEWALQRAQELQQAAEIIQKQVQHRNPIWLKSLKDRNVGQDVSNLVTDVRRHKGSARVRDTTWPRVGDYTGTRRMRNTMGYQKDIENVTPRSINDNPESSRANEHTNRCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIE0</accession>
    <name>A0AA38NIE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Family A1 protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_388893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793408">
        <property type="protein sequence ID" value="KAJ3783677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIE0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="105"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="423" mass="44852" checksum="8139BAD57FB1BE10" modified="2024-01-24" version="1">MRQLTAGCNCTSLLYSTSELKMFSALSLLTFVTLALNIAAKPVIIDRSPVLSIPLTKIHNITSGHNLVASGLARAQSFKDRAKAHDLAEIRKRQSVPVANEVVSYIASVGVGASDTQYQLIVDTGSSNTWVGATTKYVPSSTSTNTGDRVSVSYGSGEFSGTEYIDEVTLSSSLVIKSQSIGVASSSEGFEGTDGIIGIGPDDLTEDTVSGVSTVPTVTDNLFSQGTIAEKVVAISFEPTTTDEVTNGELFFGGTDSSKFTGDITYTTRTGDYWGITQTVTYGSTTIQSSLSGIVDTGTTLLYLEENGFDKYIKATGGVLDDETGLYKITTAQYNALEDLVFTIGGTEFSLTPNAQIWPRSLNTDIGGSASSIYLVVANLGGEEAGFDFIDGYAFLERFYSVFDTTNNRVGFATTSFTTATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIY1</accession>
    <name>A0AA38NIY1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793366">
        <property type="protein sequence ID" value="KAJ3784697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="17892" checksum="F07B17D26E3A940C" modified="2024-01-24" version="1">MSTRRILHSRRRAMSDPAAPSTPTPGDYNSRPESPLTPIELEGPSDGPKLEEQGHESELYEPDPDELNEPSTNPVEPPRSSGMAGGRDISTGSNAPEKPQVDEPRLQLETSQVNENSLSPEQELTVKMAEANLNDSEREKIARRHSSIRILAEDEESREEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ39</accession>
    <name>A0AA38NJ39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="9">HIBADH</shortName>
            <ecNumber evidence="3 9">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_368488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 9"/>
    <dbReference type="EMBL" id="MU793650">
        <property type="protein sequence ID" value="KAJ3780813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ39"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="201"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3780813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="344" mass="36469" checksum="D3A6CE89A881A3F4" modified="2024-01-24" version="1">MKASLRWMNVIGPSSMRSRSTSFIGLGRMGHEMAYNLFSKQFAHANENRFVVCDAIPESAQRFCSNFVKQYPGANINIANTPEEATRASQTIITMLPSSPQILSVYHDGIIPTLRKLPADQAESTFCIDSTTLDVDVARSVAKGVAEARSQMVDAPVSGGVTGAKAATLAFLVGGTVTGFKQAQPILALMGQRIIHCGPSGAGLAAKICNNLILGVQQMVVGEAMLLGTKLGLDPAVLSSVISSSTGNCWSISVNNPVPHALPEKSPPCEREYEGGFATALMLKDMGLASNVAALAGCPVPLGQAAETLYAQMVEEQPELAQKDFSSVYKFLKQVMEDGKTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJG5</accession>
    <name>A0AA38NJG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_366608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793553">
        <property type="protein sequence ID" value="KAJ3781488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1435" mass="154129" checksum="33AB21100FA7AEE7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJN9</accession>
    <name>A0AA38NJN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_120789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793594">
        <property type="protein sequence ID" value="KAJ3781159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24622">
        <property type="entry name" value="TMP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="132"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="190"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="634"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1042" mass="119214" checksum="898A1713C84EE78E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJP8</accession>
    <name>A0AA38NJP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_379793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="MU793589">
        <property type="protein sequence ID" value="KAJ3781204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJP8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="325" mass="35745" checksum="9091C8A676B9B04C" modified="2024-01-24" version="1">MTTSLDYLKQTGTVVVSDSGDFESIDVYKPQDATTNPSLILAAANKPGYARLIDAAIKHAKSKSDDLDVQVNTAMDRLLIEFGKEILAIIPGRVSTEVDARLSFDKEATKAKAKELIALYDSVGIKKERILIKIASTWEGIQAARELERDDGIHCNLTLLFGFGQAVACAEAGVTLISPFVGRILDWYKKTTGKSYEGDEDPGVQSVKKIFNYYKQHGYKTIVMGASFRNVGEIKALAGVDFLTISPPLLEELKKSNDQVPKKLDAAAAAKDAPIPKVSFIDNEPEFRWTLLEDQMAFDKLHEGIKKFAEDGEALKKVLKEKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK26</accession>
    <name>A0AA38NK26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP citrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Citrate cleavage enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">GGU10DRAFT_81039</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="5"/>
    <dbReference type="EMBL" id="MU793477">
        <property type="protein sequence ID" value="KAJ3782418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="28">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="27">
        <location>
            <begin position="299"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="26">
        <location>
            <begin position="548"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="25">
        <location>
            <begin position="719"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAJ3782418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1168" mass="126567" checksum="4EFCBE05FC5D6C17" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK33</accession>
    <name>A0AA38NK33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_363878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK33"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041315208" evidence="2">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="88" mass="9480" checksum="DAEF2E73170BC548" modified="2024-01-24" version="1">MRFYAVLLISSLLATVLAAPHAQLNHDSDTASLGRRGSTFSKSSPTQAAVQSPVQPSAKSETFPQSQCSSITENLRFEYFAPFSSRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKC6</accession>
    <name>A0AA38NKC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_83404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793484">
        <property type="protein sequence ID" value="KAJ3782314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="623" mass="70691" checksum="EC2C238ECF27240D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKD5</accession>
    <name>A0AA38NKD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_249430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKD5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="51" mass="5826" checksum="8F8EED60ED374818" modified="2024-01-24" version="1" fragment="single">SSGSLLKIPRDDMDPDDLFVKHNISEIKLIQQRLRCSDADAKQEELRLMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKE6</accession>
    <name>A0AA38NKE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_408431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793478">
        <property type="protein sequence ID" value="KAJ3782404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="163" mass="18360" checksum="66CD46078DCFABA7" modified="2024-01-24" version="1">MSERPAHEIVIASTEAEIQQCYKIRIDVFTHEQGFPIETELDHLDPIATHFLLRLTPSLTPVGVIRGSKSSESGYYKLSRLAVLKDYRQFKFGRELVEALHKWVQADAREADAGQGIGSAKVVCHSQIPVKGFYAKFGYISEGDEFDEDGDPHQKMVLKLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLG5</accession>
    <name>A0AA38NLG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_357402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLG5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="113" mass="12021" checksum="2D28311573CCFBF6" modified="2024-01-24" version="1">MSSSSIPPPPSSAPPSTGNLLHDSFEAAKNVEKLPCARNSLLTGLAAGTGVAFIRGVSTTPIVAGHWFTFTFVAVAAIAHQVCVRQMETERKQVMQIIESAPKRTLKKDSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM73</accession>
    <name>A0AA38NM73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_291606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM73"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="77"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="498" mass="55193" checksum="6760B050DBBE1797" modified="2024-01-24" version="1">MANAIFYAIGICAFVLLFTVGYISLNDAALTRIPLRVLNLPPVRWRKAEFEAVTEKMKECPPSIEEHLPPKTSRKYIVVGGSGFLGGWIIIHLLKRGESPLNIRIIDLRPPTRLDFTSGPAKEVQFEAADISKAEQVDAAFKAPWPAASSANAEITVFHTAAIIRFYERHRSLLPLSKVNVLGTGNIIKAARATGASILIYTSSGSVAQRNTRLLLIPWLEKEPEHFVQVLGDQEPNKLPQTLDEFTCCYSHSKLEAEVLIRAIDGSSSGPNEDKVLRTGCIRPANGIYGPGADLWEYFLNKKKNITFFPNLITSNIYVENCSLAHLCYEQRLIEMATQYEGLVRSIPDIGGNTFTVTDPQQPVLWSDLYAALSYFTDGSCQYSTISPTLLILVSFVVERYYIIRHRLCSSIPVVARIAKYLPQLRGDLLALQPSVMVLSYAHILADDSRARLSPSDGGLGYDAPWTALEGLYKTIKQFETEGSLRPISLNTGFGHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMA1</accession>
    <name>A0AA38NMA1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_427470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="867"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1399" mass="154298" checksum="AD98E78C9D31F1FC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMH3</accession>
    <name>A0AA38NMH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_169210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041267283" evidence="1">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="14609" checksum="B2752D6ECD739063" modified="2024-01-24" version="1">MPRLSSTLAVAIIALTAVSTVDALSLSTSNERVYSRHFSRHFPVPRHTNKHDVAVSGLETVGKVAVAGAEMQGASVSEPQRRSDVGNGIRATGASAEFHEGYVVPAPTEATVTIKNARGLHMLQHSTVDPSVKKQPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMV2</accession>
    <name>A0AA38NMV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_385657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMV2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="65"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="266"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="773" mass="86640" checksum="CF9B43425EB248A6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMY1</accession>
    <name>A0AA38NMY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_135051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22599" checksum="C8A29A96DEE8377B" modified="2024-01-24" version="1">MSSIEMDDLSIRSTKKEISNDEGNQETQDLPEAEKNEAISAWTMMAGSLLTVLAAIFSLFPQLLLFLSTDTPSALTSLERFLSLHFGIWLFTIAVALVLNIPSTSPLPLGLSQPDHPLLKPFSFACLLSSFISYNTRSVGSLATIHCSLTAIVGLWGLWAMVFGSSVRVSKKTGADKHTSAFIFGNKSAASKQKKEWLRQQKDGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN04</accession>
    <name>A0AA38NN04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_142370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="18958" checksum="40E7F32DA419EA93" modified="2024-01-24" version="1">MTEKIKEKLNNLRLEADQAIERAEAAEAKNKKLEQSLLEKEQEISSLNHRLSVLDGELEKAEHSLQDAKRENMDNIGSKTTSEGLQRKIQLLEEELDAAEKNAKDTVEKLRQVDVKAEHFERQVQRLEQERDQWEKKYEEAQAKYQQSQKELDELVQQMEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN71</accession>
    <name>A0AA38NN71_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CwfJ C-terminus 1-domain-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_346737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="699" mass="75973" checksum="F941F153D2B6A692" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP20</accession>
    <name>A0AA38NP20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_275223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MU793465">
        <property type="protein sequence ID" value="KAJ3782600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="406" mass="45459" checksum="7F5DD30554E6FEE2" modified="2024-01-24" version="1">MLALISRVQNVRQDFSCSHEPNSEFFQISNPPSSAVQPKEKAALRFGCLGAAKIVPTALATPVKSHSDVVLYAVAARDKARAEEFARKHGFHKSYGGPSGYQDLINDPEVDVIYNPLPNGLHFEWTMKALEGGKHVLLEKPATDTEDEARQIFALAQKKGLVVLEAFHYRFHPSIQRVKAILDSKELGDVKSISAALSAPEGTAKPDDIRWKYELGGGSTMDPGSYTVNVLNYLASPSKPKSILSASAERYSSAPQHKQVDKEFTATVSLENDILGELFSNLNESRILGIIPRFPKLKATVHCEGGTVEIFNFLIPHYYHYIAVSSIGKQSRVEKAYKFTNGSKGEEWWTTYRYQLEAFVDKVRGRKPQTWVEPQETITNMRLIEEIYAKDGFGSRPQSNYEYHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPP4</accession>
    <name>A0AA38NPP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_353259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPP4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24698" checksum="EAF89E4FF109A2BD" modified="2024-01-24" version="1">MKPEHKPLNAYRKISLICVFLLLAAFVLLLLVGISLPIVHPVYIIRVYATPTGPATSLGTELRFGIWGVCAYSQLNPPSVLNDDGLCYGPRLGYQDVIPSVILAQIGLSQGLIDAALKGLLVVLIIHIVAAGFSLAGLFTSLFLASHSMTILSLLLSVITAILSTVVFVIDIVVAAVARVKIPEFSNDLSVGVGNAVWMVLGALVASWLGVIFLSARACFCCGVRRRDHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPU5</accession>
    <name>A0AA38NPU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_332086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPU5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041270678" evidence="2">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="225" mass="23308" checksum="FAB83190167B7EE9" modified="2024-01-24" version="1">MRFSTLSLLATVASAAFSFAAPVSPASNALEARCLCQDIHSIIVDVTTTITPLVEELTYITAENCTVEILTPIIGEIKVVLSTAITEVKGLTGFTLTAVLTTVDGVVLTLAEVAELVCVLLTLIFGALAAILKVVTRAEAAAVAELLCEVVALVATLLELICNLLGGILAILLPLVGEIVFTVIASLGLTAQFSFFNVSWATVSSTLITSATTVYSTSVATMTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQI7</accession>
    <name>A0AA38NQI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-dependent hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_67163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQI7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38673" checksum="EF445B6850A68D94" modified="2024-01-24" version="1">MSSTELPSSEILRHLVDVHCHPTDAPSISHASMEKLGITICAMSSKASDQSLVYNLAKSYPKKVIPCFGYHPWFSHLICLRGNVSKEDHYRELFYVSQSDEDLETLNTLLKILPAPIPLDDVIMELRQNFRDFPDAMLGEVGLDRAFRIPFDYDASPRKLTPFTVPINHQVAILQAQMDLAVELGRNISLHSVKAHQPTMELLARMEIQHGVDSWNRISLDLHSCGFSPEMLKDIQRRYPNAFLSLSTVINGRSPNHISLIKVCDPLRILVESDYNDVDMCTEQTWDMVRTVADVKGWLIETEWNEDNDHSSERGTVRRLEENWLRFKAGHHSAKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQQ4</accession>
    <name>A0AA38NQQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_54474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="673"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="871"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1105"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1336" mass="151982" checksum="AA673EDC8DD1BD91" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR49</accession>
    <name>A0AA38NR49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_44406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="149" mass="16247" checksum="1FD9E210BEAEFE48" modified="2024-01-24" version="1" fragment="single">AYVAVQARFALSSRSSWTRSDSKFKFDRFYLNILSIFAHASDRWKESLFKFWNRECFHDIPNTAEAPANDSELASLFTESSTPEDDDSEDDDNQQGAAYRGVNEGGGDNDNGGNGNGGDSEDDGGQVNGGDGYIDEGDNFYNDGVGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR86</accession>
    <name>A0AA38NR86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_38360</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR86"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 21" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="244"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="571"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="786"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3789623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="850" mass="91347" checksum="89C5E59ED1B7DC98" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRE5</accession>
    <name>A0AA38NRE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome maturation factor UMP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_283801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="139" mass="15648" checksum="547E1AF19FFFE0E2" modified="2024-01-24" version="1">MDPSFRIVPASAPKSASVAQTSNSLGLHDTLRYGPRMIATEVKTEGDLKDRLQNWEETQDNLKLTMMRNTYGLHAPMRLLMERNIVSANPHMPVLPQTNLQLDILMGRDESIEAADVFAGPLNGPPLDIHYDMEKKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSV4</accession>
    <name>A0AA38NSV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_371297</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3790448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="387" mass="44050" checksum="E242623C1EB566E2" modified="2024-01-24" version="1">MTTDKAARRAKFESVWSIIHDELLAHFKACGMPTEAQEWYSKNLQYNVPGGKLNRGMSVVDTVEILKGRPLTDEEYLQVAVLGWGVELLQAFFLVTDDLMDSSITRRGQPCYYRVPEIGLVAVNDAFMLEGAIYHLLKLHFKKEPYYVDLLELFHETSYQTEIGQLIDLITAPEDVVDLSRFSLQKHSMIVVYKTAFYSFYLPVALAMLFCRIPTSYTLPSSTSPVAPYEVAKAILVPLGEYFQVQDDFLDFAGLPAQIGKVGTDIVDNKCSWCINTALSLAGPEQRKTLDENYGVKPTQEEREIAKKMAEGKNGEEQGYLGEAEKRVKAVYEEIGLRKIYAEYEENIYKELMRLIDQIDEGSPGQESVLKKDVFKSFLDKIHRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT04</accession>
    <name>A0AA38NT04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_371202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="360" mass="39746" checksum="089305849DE6A040" modified="2024-01-24" version="1">MAETEAIQPTNGGEEALIDDNEEADKEILLMKQRVAEMEAEAKKLRELQAAAEAGQQDATAPMDTDEDKASADGRSVYIGNVDYSTTPEDIQGHFQACGTINRVTILCDKFTGHPKGYAYVEFAEPEHIDAALTMDNSLLHGRLIKVTAKRTNIPGFTRGRGRGGYRGGYRGGYRGHGGYAPYRARGRWTASSSTRSMSTTVQTVIKPYPFSKTAIIHSEPYVPPPAPLVQGKGLMPYLQKNLTTPEKQTMLRELFGRHSTNRIYPGSIVGVMLEHAPFTFTGVVLAIRRRGIDTSMVLRNVIQRTGVEMQLFVNSPHVINIKVIQKPPKGRMKRAKLYYLRYSPEKMGALAGSKKGTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTE1</accession>
    <name>A0AA38NTE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_302476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTE1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="129" mass="14138" checksum="300FC212384F8D24" modified="2024-01-24" version="1">MANAGLGVPIKLLHESLGHVITVEVKTGQLYRGKLAEAEDNMNIFMRDATVTGRDGRVSQLDQVYIRGSMIRFFIVPDMLKNAPMFRRSGPNGMRGKGIGTARGRATIMRANARRGRGVAPTASRGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTE8</accession>
    <name>A0AA38NTE8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CDF-like metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_257798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTE8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="82"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="407" mass="44068" checksum="6F4BE2DE41542530" modified="2024-01-24" version="1">MSRRRQHSTHENGHTETKKDSTEHDDHNHHDHDHDHEHGHSHSHSFFGGHSHAGEYNYGAEKIMAAWEGSGNIGDKGSSITILGLLSNVALTGIKGVAGWYMHSASLLADAGHSLSDLLGDFVTLFCWKLSRKPPSDWYPYGFAKFETLGTTTVSLLLIGGALGIGFHSYHVLLTALSETAATLPAGTMQSILANVTATVPGVPEVLSHHSHVEAVDPNAAWFAAISVLVKEWLYRATKAVADEENSPVLLANAIHHRSDAYSSFVALFAILGSWIFPKLPLDPIGGLLVSFVILQQGIGLLVGAWGDLTDAGVSAKTRQSLKRVLEPLVASPSSSSFSISQPNILAISGLRARRAGSLMFIDLTAEVPSNLTVHELVVLEEKILQTLKEARKEVKEVHVRFKPVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTR4</accession>
    <name>A0AA38NTR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_370825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041217426" evidence="1">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="195" mass="21941" checksum="95859C1B0104B4D4" modified="2024-01-24" version="1">MRLLCRENYFIYLLAFSFLSVALAAVVSGPRLPPANPQQPNSLSPTPHVTLTSVHFPIDDSQEKSKDGALIEGVIFKFMRQIIKSQFELGVLNKENFKFIGSPAKPDKEGRYKFDLTLSLDPPISDWKGKGAVRFEEGGFMQQTRIWGTLNDTVGGRVAAINDNEFDMNLFMRGRPMDVYLSKSKDDIGEKKSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTS1</accession>
    <name>A0AA38NTS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_338973</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="32"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="394"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3790886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="531" mass="58162" checksum="A4708891456BA8B4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTS7</accession>
    <name>A0AA38NTS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_302251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTS7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44502" checksum="2E8C052BFE5C54C5" modified="2024-01-24" version="1">MFCTSVWTQSSRDNRLAIFVFTVTLFAFVVESQLTQYIQTTLNYRHPFFLFWIVHSSFIISLPCHLLYLTFTTPNSISALWRGLFLTITQHLNGLDESSSVDSTRFPVKKFIYLMLTLTAAITMPALLWFAAIEMASVTDVTAIWNTNAFFAYLFSVKVFGLKWEAQKLGAVMLATVGVLAVVYGGSTVSSPSNTVEEAAITFPKSTGPLVGNILTLIASVGYAGYQVYYKKYVSLPSALEFAEDYRPLSASEDPEFDTMHASAHLDRSVQFTDSNETAYPPPFGLYSNFWTSAIGACTLAVLWIPLPILHWLGVETFSLPRNPTTAGAIAGIALTGSIFNAGFMITLALWGPIITSVGGLLTIVLVFFSDIILGATETLTIWGIAGSATIVVAFGVLAYDMFQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTV4</accession>
    <name>A0AA38NTV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S17-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_391755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="154" mass="17553" checksum="FE899CDD178AA104" modified="2024-01-24" version="1">MAEQIEKAFQKQPLFHNAKAKVGKKVSTRERRWYKDVGLGFKTPAEAISGTYIDKKCPFTGEVSIRGRILTGKVVSTKMTRTIIIRRDYLHYIPKYNRYEKRHKNLAAHVSPAFRVEPGDVVTVGQCRPLSKTVRFNVLRVAKNKAAAKAFGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUC6</accession>
    <name>A0AA38NUC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_1904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041237729" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3791270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="326" mass="34947" checksum="C284138A3A209551" modified="2024-01-24" version="1">MFVQASLIALLSGSAFAGTTIWSGSFNAFPNVSVFDEWSWADEVGTYQWYIHGTEPTSHYLALSPSYKNPADTAEVNGLMATIDSTAEWNSDMERTELIPQTTQNLGVGNLFYHFSLSTDPTGLNAPDSTLEHQILFFESHFTEIKYGVAPNPTDLQWMVSSQFQWGTPLVPGTWYNFAYDIDFTAQTVGLWFSTGGSPLTKVENNVAAPTSTNSEDFHVGVLRIVNTPAPENWYISGVYIENGPITTAIGSGNSTGSSSSASSSSSATSVTSTTPTTTISTPSSTPTATVPEYAQCGGTGYTGPTACASPFTCTAISPPYYYQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TY42</accession>
    <name>A0AA38TY42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_261003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TY42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10152" checksum="A2B9281000DED673" modified="2024-01-24" version="1">MDVQSSLSEHTLTVQLPDHIKHEMVTISVLKGNKLKVIADAWHMEAECHYEWVINFPPHDIDMGGVHAQLDASGLLVISVRRRPRYHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZS2</accession>
    <name>A0AA38TZS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_340918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="853"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1463" mass="159256" checksum="D0B23895C82467FF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZZ1</accession>
    <name>A0AA38TZZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_371247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="542" mass="63361" checksum="515BB055FE2E9B96" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0X4</accession>
    <name>A0AA38U0X4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_414057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0X4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="682"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="778" mass="86284" checksum="4957D8000E8AC068" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K869</accession>
    <name>A0AA38K869_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_390666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793567">
        <property type="protein sequence ID" value="KAJ3781374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1385"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1552"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1568" mass="173313" checksum="DC7677973942684D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9Z0</accession>
    <name>A0AA38K9Z0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_428161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793353">
        <property type="protein sequence ID" value="KAJ3785109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9Z0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="291"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="649"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="786" mass="86888" checksum="5B387FA5F97F4443" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAG7</accession>
    <name>A0AA38KAG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_386845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="274"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="464" mass="51376" checksum="5CB4F8F0C49E290C" modified="2024-01-24" version="1">MTMTMTAMYSPSHTSQDNRFEPRPLILEPVIPQGSPRPSDVRSTSRASCRSRSRSPVAPPSPHSAPVIPNVVPISPLNSPRPSDHEVNRFSPSASPRVLSPAIPESSFENFLYPGYQPAFMSSRSRSTTPEIFIPPLELSDPAPPTTNPIPVEEPPASTAAPFWGYPYGHVSYPYFNYYPPQPYPYHSTPGIAPGVNMWPPPPLSTPYSMPQFLQTPAAYGYSTPFGVSTVHNTPFPNTPMLAMGPPTPWVPTTPWAVESPAVRVNPRLAPGALRWDLLHHPDQSRYINDFGALKAPKFSDEGLTMAPPTSGHRMKVTKIEITSSSHSVLNYWMSQWGPIPLPHHKVFDILSAIYNYLSQPLTPQETKLLLDTPQNIVHARRAKEARAKDSWALECVILQEEGYRRIDVIGVHRGFGGITVEKITPTTLPVIAEENGEAEQEAEVELTIGLSPLHRSDADENWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC16</accession>
    <name>A0AA38KC16_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_345620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC16"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="429" mass="46617" checksum="08AB57D839D18F01" modified="2024-01-24" version="1">MTQTTLLQYEAPWPVYAMDWCKTPSPKEQMRPRSSFRLGIGSFLENFSNRIAIVGLEDEHILVEDDYTDYPDFVTLCDAPHGYPVTSLQWQPASAISYQWSQKSPSTEFLATTGDALRLWEYSGDAPPAMSNFVGRTPSSSGHSLNLKSALSGQSKVQNNSNGAPLTNFSWNEKAPSLIVTSSIDTTCTVWNIDTSAAVTQLIAHDREVYDVAWLPTSTDIFVSVGADGSLRAFDLRSLEHSTILYETPAPKNVPPPSVSPSTSARPPTSPLLRIAFNPSDSNYMSTFHMDGSEIQILDMRSPGQPVLELKGHHGQINAVGWGSSDQPLLATAGDDCQLLLWDLANHTAASASMNANSPRSASSRLNSPRPDVKKKYVNEPAFAYTASSQITNLAWSPVIQGLNLSTGQSTAGEWVAIACGKTMKALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC74</accession>
    <name>A0AA38KC74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_116155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793579">
        <property type="protein sequence ID" value="KAJ3781273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC74"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="100822" checksum="704144558BCEE6DD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCQ8</accession>
    <name>A0AA38KCQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_275813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793484">
        <property type="protein sequence ID" value="KAJ3782323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="53"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="836"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="957" mass="103025" checksum="C45B4553ABF58950" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD16</accession>
    <name>A0AA38KD16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_396648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793451">
        <property type="protein sequence ID" value="KAJ3782818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD16"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="66"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3782818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="487" mass="55602" checksum="58BC2FC86519760C" modified="2024-01-24" version="1">MSKRKISSAQELTEGTPSKSKRRLDAYSDSPTTSPIAKQTMLAQVGFLPYSSVTPQTFLSKSIPFQQPMPLTSFSYTPDHIQEFNDSALRYFRPPPPNAYLGYGYERWVRRPEGRSRIDSLLRAVDRVTDGQRKKMNLEDVGVVAWRGVITRILTAPYEDREGWEMNVMLIKGTLYLEEHRSESLITEKNNIKPHHRKRMYYGYAFESYCTTDIDMPSYSKTASTRSNEPSHVAHVGDTLGWGGDVNTNIQWCSIVRTKLGDTRFIIGGEVDCSDGQYKGTTDTFVELKTSMSIRGAADEEKFERKLLKFYFQSFLLGVPKIVVGFRTPSGQLTSTQSFQTMQIPRMVREKAEDKRISPPWNPSLCLAWCHHFLTYLKRTLAVWESDDIPNHQNPAEDPEEKVQHDYSPIPTQVWRVSFLPGEGARLVKLDRSDVEEVVNGEDRVGFIPRWYWDKIKSSSAHASHSDFIRSTTTEQPVQGAAGGWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDA6</accession>
    <name>A0AA38KDA6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_361412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793428">
        <property type="protein sequence ID" value="KAJ3783253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDA6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="275" mass="30510" checksum="CBF4652A1B3B3436" modified="2024-01-24" version="1">MKRNSNSEIMISFKFVSVFDLMIFVGIASGLRITTVDQEVLEPIHAQNMDRMGSISFLSGFEALATAAMGCGDIGDSCAVFSCCDWALCSPYNYKCHADVPWSRDQLAPPTYKNEDARIAVGETISFEVYRRHNGGQFKGYLYQLEGMSKYGWTEIGVTSDYDKRGIFHVVQADSKATRLAALAPGDQTEVYKLVNNDNVDWVYINGALDDQSSNTQLNFVKGSFGADKQSYHALWFASTMRTSFKSALNIDGDGEGNLKDSGYTAYLQVIREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDI9</accession>
    <name>A0AA38KDI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_360337</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793411">
        <property type="protein sequence ID" value="KAJ3783613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000161">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1030.10:FF:000002">
        <property type="entry name" value="cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="14">
        <location>
            <begin position="413"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3783613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="762" mass="88358" checksum="2EB97494295E8277" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEM4</accession>
    <name>A0AA38KEM4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_427893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793338">
        <property type="protein sequence ID" value="KAJ3785563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEM4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3785563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="306" mass="34876" checksum="D7F2BDBDEEA40E5E" modified="2024-01-24" version="1">MNNELSDQPYTFLRIKRKRNEEPLDALVVESGARRKKPKGRNGVFQFARTIEEGVWEDEEQKKAIQHQLSILAHQPTTQEAPALLPDTAAATSSTLKPPQATDIRRYTIIERSPPIDHLPLRKPTSPPQILSSRELATQRANSDFKMYDAVLENPPAEEQIDPALEKLLQDYLKRMSFEIHVKPTRQYIVSVLPVETSSVTTPTASKAEDYVWDIFYHRPRTYTQSLTDVVAVGTVSGLPPLASGDSDSDSYSEEEDEADEDSNAEEWYTNDYPEEEESDWSHDDDDGSDEFHENTVDSDVEHEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFM4</accession>
    <name>A0AA38KFM4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">GGU10DRAFT_162719</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFM4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="84"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="447" mass="49732" checksum="5E7EA8B1B94DB192" modified="2024-01-24" version="1">MTSTLELPLRKEFLLPINGEVGANRLWNESDKPCTYLCGNSLGLMSKRSKELVEEEMSVWATRGVIGHFDHPHKRGWVGLADHARSYLAEIVGANENEVACMGTLTANLHLMMDSFYKPTSERYKILCEAKAFPSDQYAFTSQAQAHGLDPAEAVLELHPRPGEFCLREEDILQAIEKDGPSIAVVIFSGVQYYTGQWFPMHSITQKAKEQGCICGWDLAHAVGNVPLSLHEWHVDFAVWCTYKYLNSGPGGIAGLYVHEKWNDSLKPKYAGWWGHDPSTRFAMPPKFSPIEGAGGFQQSNPSILAIASLLGSLETFKRAGMMAPLRKRSIVLTNFLENLLFQSKHFVSLKDISTKYQEGQGKPGFTIITPHDSKDRGAQLSLLFLPLGTGVMQKIFESLQSHGVIGDERQPDVIRLAPVHLYNNEADCETAAKFLDIAFDKFAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFV3</accession>
    <name>A0AA38KFV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_151151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFV3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="427" mass="47524" checksum="C5FFBC6D2D0691AD" modified="2024-01-24" version="1">MNPSPALDFPQSQTNIGYAYTLGTLIFVAGVPPQRLAEYLIGFNSQTMNEFSVLEGDFPPEVNPVVTTLIILLGPALNLISSSILSKLSQLIARFTFLVNIEIRIHESVWSRRLVGRLPIIPPSVKRAIVLVSNLLLDGPERVRVTYDANASPFTTSLTTALCGLHLTMKGHNLDLSFVFAVHNVLAAVDFPELCKAEIEISHKRSIYLRVSGSMRDARNVIRPIMVVAHIPEFARRQYFLKSFIVDASKLHHQDEFRHCMLSVLSEAPRLQVLGINIGTVNASETYKWMDSVRVLGGFRELVHIKITHPRPLNLSDADVAYLLRSWRHAEHVSLNPRASGSLIAHSQVLLTINALKVAAYQAPPSLRHLGLFVNADEVSVRGFRDIPPHYSAEKIELRLVTASAHRARAVTRLVEALFPSARVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFZ1</accession>
    <name>A0AA38KFZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_143735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="540" mass="61205" checksum="123F7FB94252367C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG47</accession>
    <name>A0AA38KG47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_432871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041425877" evidence="2">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="30696" checksum="BF3B67DA5C8593E2" modified="2024-01-24" version="1">MRFELLQVAQAIALFSTSVLASGTSSSNFTTPGSLGILRFNPGAEDMHTILARAERETPQWQGFVRGKRLPLGVPSTSESRSTPSNLTPRAGPPPGPSEATIGYLHIRSALDGTSLGYAASAFNSFGEYGPTTSSQRLKVTIDTSMVNQTISIATTNGQDADLLFMVGITGFSNDASGLNPGKYNYVYVGAGGQTAVNVSPRSGDNSFSRATGNPEGIESAILTLLSNQFVLQSNFDIVPFWINGDGSKPNTSLGLHENVLFLTGDQDIFVKTFGSVTWVILSFEPELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHX9</accession>
    <name>A0AA38KHX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_108081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="392" mass="42457" checksum="F2B77CD967ADCBAE" modified="2024-01-24" version="1">MILVHKQQYPSSSPYAHHRRHPSAPPAVVVQPTKVPGLLSLSKPVQRQQPQHLRQRPSPKSKQAQVIPLPRATPASEVTSSLKPSPEITDHTPSPANSRGRQHLKPQQKQTARNNSHSAVRGRRNNTRQQSPPIPTSQAEVPSSPTYLSNNSNPFDPFQDDSDARNKFIRPASIPTLASRPSGKLARRRHNVAPSNATSKAIPVPRNFSSSTPNLSRSEPRDSSLRTLKVNPVFKNGVFPICDDLTDTEYDSGDDSTPPATPTRSRAARFTLGLGNGPRTAPITASASTFPFVVSSTPSPAGKKSFRTHFRGPSEGVFAMSSDEESSTHRAAGRHEIDLKALLGLAAQRLPLSEESDQEREAAAAAAAYFASSNFQNSPSPDELPPPSFAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI63</accession>
    <name>A0AA38KI63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_330293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI63"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="244" mass="27735" checksum="8114A148A1F2DAE1" modified="2024-01-24" version="1">MCGNRANTLSKVKYELCVVTLRKKGDELKNLDSGMEGWPANVNFSDIWHWSMTSRAKHLGPLGDIYRKKMLETTLNLRRRREPGVAGEELVSSSRPCHTQISPFYNHSRSMQIIKVFHCPRYQVSSGSAECNTIFYNVIPNFTASSDELPSQNHDLQAFNLKTYSSSKESVRLGLLSENLIPQPFSLHEDSPIRLLFVTSCSDVRSISISELLVYETPRRNDIDRRLMLWTTLFCGLPMATGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLA9</accession>
    <name>A0AA38KLA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_369115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793694">
        <property type="protein sequence ID" value="KAJ3780585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLA9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="367" mass="42881" checksum="3E7531E3A9F1B79E" modified="2024-01-24" version="1">MNVSVVGRKKYLTILLSLVGAFCIRLLIPFTSSAFSSTSDQDFSYNTNAPLPTGRGTANATLVFLARNSDLSGVISSMQHLEEKFNKEYGYPWVFLNEEPFSDDFKTAVQKESSAPISFGLIPSEDWYQPDWIDEERATEGRDKMKAANIIYADNVPYRNMCRFNSGFFYKHPLLQPYRYYWRVEPDIKYFCDVTYDPFDYLRDNKKTYGFTISFYEWEKTIPTLWATVKEFMALHPEHIASENAMNYLSDNGGDTYNLCHFWSNFEIADMDFWRSEAYTSFFDFLDSKGGFYYERWGDAPVHSIAAALFLPKSQLHFFRDIGYRHEPFQHCPKGDDWVRGMCTCNSYDTLDYAPQSCISRYEKMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLG8</accession>
    <name>A0AA38KLG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_277213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793538">
        <property type="protein sequence ID" value="KAJ3781634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19399" checksum="5F8B4731116B5825" modified="2024-01-24" version="1">MCNGSTPESFSSAIAVLQMSSLLVIDCEGLNLGSSWFSFRPQYLSYCPTKSSEFPFRFCRSHFLPPALFSFLTNPSILKILYDGRMDFCALYHTYHIDFDPVLDLQLVDICSRFARGDYSVASHERRLLRCFSHKQIRQNKDRFKNIHVLRSLGRCLEEHGCKEYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLZ8</accession>
    <name>A0AA38KLZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_82110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793482">
        <property type="protein sequence ID" value="KAJ3782354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLZ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="334" mass="37982" checksum="08FDC7A80157819C" modified="2024-01-24" version="1">MWQSSRSLHFSRAHTSFASPVLTLRRITLGGLPTHFLMPTEHDSFGCNNNRRIQSLVQLCQRVAGNHIESISSVGELPFTLVQPILERCSAEQLLRLEDASPHLKGDTEELWRTLCRRTYSAMMERLEDGTDTVPDSWRTHFYILREAEARRLEEVGSRIRSQRLEADERKKEREVKFTERLPPPKRQRTGWNMPTQPRTLFQKTRSEASRLQKNMYNTRMIPPMLKAKDYRATGSIASPPLLAQTSYSNRVTVKTVTRRPSSTTAGSSEPDTLPSKTLNPSPLKPTTSTSSTWKAETRSLLSSSNGTLTIPRKYTPKNAQIPSSDARANYDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM20</accession>
    <name>A0AA38KM20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_365861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793531">
        <property type="protein sequence ID" value="KAJ3781710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041418022" evidence="3">
        <location>
            <begin position="24"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="383" mass="37459" checksum="465FAA743BC5670C" modified="2024-01-24" version="1">MQSFTTFQFVFFLCFGHFSGVFAAPVPRWNGKHHWSSSGNSATSTTSASPAASTTTSWDINGLPVTIVSVSQGPVLTLGAGSTTVVGSSTYTVSPAPIATTTTSWDINGAPVTVVSVFNGPELTLGATGSTTTVNGATYTVAPSSVSVSMSTSWGASGAVTMMSASGGPELTLAASGATTTVGSSTYTVVPTSVSSVSVSTSTSWGASGAVTIVSASGGPELTLASVGQTTTLGSSTYTVIPTSIVSVATTTSSGASGAVTMISPSGGPQLTVASTGITTTIGTSIYTVISPPAPSVSTSTSWGPSGAVTYISASGSTPLALATSGFTTVIGSSSYTVATTTATHSPSNAAGSLRPFGFSSVLSTGLFAMVIGTLFGGFICIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMJ4</accession>
    <name>A0AA38KMJ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_317251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="MU793433">
        <property type="protein sequence ID" value="KAJ3783164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="730"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="929"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1178"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1276"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1382"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1295"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1308"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1382"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1399"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1427"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1455" mass="162820" checksum="BF7BAB6FC03CDC12" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMM7</accession>
    <name>A0AA38KMM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_408360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041224113" evidence="2">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="177" mass="19212" checksum="C97CABAC481B17A2" modified="2024-01-24" version="1">MRFSTVLIIASFLATVFAAPHSQINRRGESGQVSPLSPTGPHTSNGDQKRTASPSLTSEDEQTALPKLANPVQVHIPSGTLLLKSSSIGTQAIARSHEHPSYVDYPLSEYKGKADDFVLRVLLEARSPSDAGFEKMVGQLKAAGRWVDSGTAFLDDFKKKLSRPVVVLTKQKPQLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KND0</accession>
    <name>A0AA38KND0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_361334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793427">
        <property type="protein sequence ID" value="KAJ3783270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KND0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="828" mass="93191" checksum="2DA3219EC826D41A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP78</accession>
    <name>A0AA38KP78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_395933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="81" mass="9143" checksum="90976085F4CA8A65" modified="2024-01-24" version="1">MNARPHKQSMSELKLRRLAEHNQRLKEDLARPRVRVSEASSSLIRYCKTTKDHLVPSVWGPVGKGEDPYAPPAQGCNCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPF5</accession>
    <name>A0AA38KPF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxidase</fullName>
            <ecNumber evidence="7">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_357984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MU793379">
        <property type="protein sequence ID" value="KAJ3784365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF53">
        <property type="entry name" value="HEME PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 7 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041486474" description="Peroxidase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="535" mass="58025" checksum="AE9838D2C5A11C7F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPP6</accession>
    <name>A0AA38KPP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_354852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119562" checksum="6052DA97863FB452" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQX8</accession>
    <name>A0AA38KQX8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_433373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQX8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="384" mass="42449" checksum="5C9ACB4FFAACF8E7" modified="2024-01-24" version="1">MSNKQYSIALTVTYVPYILSELPSNLMLKAVGPNLMLPTMLTLWGIVTALQGIVNSYPGLLEGGVFPGLVLYLSYFYPRYKMNTRITLFFSSASLSGAFSGILAYGIIRMDGIHTGKESTWMVVDLYPRRPIHFLSPEEKAYVKEKLLEDTHKEEEVFSWKEVIEAFKLPQLWLLGMAFFFAATILFGLAYFSPSIIQGLGYTAADAQLMSVPPYAVACVVALVASFISDRYRCRGIVCIVSVLFCAIGFAMFLGSQSKRVQYGSLFFSATGAYMAAPTQATWNANNASPQTRRATVIAMGFILANSGGIVATWLLGSLSPAPRYTKATITLLVFSLLAALFCALNLLYLRVQNGKKADRRKTMSREDEEPGLGNHSAWYIYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR49</accession>
    <name>A0AA38KR49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAMK/CAMK-unique protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_175278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109405" checksum="90310A01586147BB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRM9</accession>
    <name>A0AA38KRM9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Iron reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_400599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793366">
        <property type="protein sequence ID" value="KAJ3784716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRM9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="291"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="688" mass="74836" checksum="BACA1F4B8BCF68B5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSW9</accession>
    <name>A0AA38KSW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E1-E2 ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_426236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1107" mass="119036" checksum="671513E02A9F4ECB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUS8</accession>
    <name>A0AA38KUS8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_363219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793463">
        <property type="protein sequence ID" value="KAJ3782637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUS8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="215" mass="23840" checksum="923907C304C1178C" modified="2024-01-24" version="1">MTVTIREARETDADAVSRICLLTAQGGQSADDLHDFKELPGLTYAVPYVKLPTTLGFVMVDDKNAGSGDGSGEVVGYILASRNSRDFDRYAAEHWWPALAEKYPPSLAKKPADKEFMELFRNMHGKSDARVSYGAANMHINMLEPYQKQGWGSKLIGKMVEALRKEDPNGGVTLGMDPRNLGVREFYEKFGFESFEGGKFNELGLKFSNAKNLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUT5</accession>
    <name>A0AA38KUT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_335359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793461">
        <property type="protein sequence ID" value="KAJ3782667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="217" mass="23819" checksum="96DDA1E0D8A34D26" modified="2024-01-24" version="1">MSDTPTQSSTQWSNHGHSSEGEPDAASIASITHSDLNIIKTTLWNFGQFTEKTDKNFTEISNNFKDLDSLLTSTFTDLRNDIAKILPPAPSAPAPAPSATVPTTQHPAQVPVIGGKTPNFNPPKTFKGKSTDVDTFVDAVSDAKLENLTQNGSAAAYASRYHELLVHVDWSEQSKIDNFYSNLKTATKDMISITKREDRPNRFDDYVGDGKESGKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY00</accession>
    <name>A0AA38KY00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_346176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="96"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="198"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="32861" checksum="C00E1C52C2B90E00" modified="2024-01-24" version="1">MNDNVIHAMAGAGGGVMAMTATYPLVFLSTRAAVKTQNENKSVYEAVLEILEREGILGLYSGLSSSLLGIAVTNGVYYYFYERSKGIFLTGGKKGLSTLESIITGLIAGSATTIISNPLWVVQTSQAVHTMDSKTRIEKLGFLQTVQHILTKFGMKGFFRGIGPALVLVVNPVIQYSVFEQLKNLLTARRKLQRKGNLTDWDFFVLGAISKLVATSVTYPYIVVKARLQAGATKYRSSINALATILREEGLEGLYKGMGSKLLQSVLTAAILFAFQRRIFLMTKAALTLRDSSLVGLRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYG7</accession>
    <name>A0AA38KYG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_360993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="21270" checksum="28173AC5B607B304" modified="2024-01-24" version="1" fragment="single">MSFPISPLNLILESDNPYNTNMYDERDGRILYQVMTEQQHETVTRVKNVDGETIASWQWRDPKPDIIVLGNGNPVPLNTWLKRSIMPFKDSVTFQDQIGRHFKWKGWGTGPPLELYCEDDKKHPIAQFVKSHPLPPSQTAQWLKAKLWVDRRGQEILDLVVISFLVLEKNRRAESSSMHRTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZF9</accession>
    <name>A0AA38KZF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_194752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793339">
        <property type="protein sequence ID" value="KAJ3785528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="39265" checksum="8E1BF173A4DA11DD" modified="2024-01-24" version="1">MSDNSSFHNPYPIFSASHRDAQDLAIQSSDASNWANSTPHNLVQSDHFSKFQTAVQRLGVFPLERANSKSDFDDGSNSDILWSHWQTHRLGFSSKFAGHLSDIATDMRKVKDATREEPLGDEDVSPQRVVRGLPKFILSIYHDELKTRRSGTGTEVHEIRRGDVLESPQKNQNSISLTLKEHNNAAPLPVKIPKWTTLWVLFSSMIGIWDLWAMRAGTGRMLFEEIVLTKSEIIFPTSIVSSHWLSDPINQVFPQATEVALNITYLVLALFGWPPASLFAFASVMLTLGQTLSLLAQVYFYPNFLSNPIRLSTVSWVLVLIFRVMIPSVNGFVVCKKLCSLLVDRGRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZQ3</accession>
    <name>A0AA38KZQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_352884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="33052" checksum="6CD873F9A856CBB0" modified="2024-01-24" version="1">MSTLVDLNEQSVTNLFDLRGVVAVVTGGGSGIGLMISSTLVANGATVYIIGPKQADLDRICGIYNDASTKLKSGCGGKMYGLEGDISSKTEAKRLAEEVAKVQPYVTVLFNNAGIQAGQFTPPSQASAAAYVSAFFDKIEPQDFNNVLNTNAVGAYWMTFAFLPLLEKWKNSEEQVTKKFVPQVIMTSSMNGWTKDSATSGLSYPYMFSKSAIGHATSSLAHELLPLGIRVNGIAPGLFPTEMSLPGYSNEAGVAVAPPDKTWGFEIPTVKTGGTKRDVGALALCLITNWFINGETVLIDGGTLLKHPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0H9</accession>
    <name>A0AA38L0H9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_346706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0H9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041230050" description="Acid protease" evidence="1">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34810" checksum="AF71F563D5E53E19" modified="2024-01-24" version="1">MFGSFSAFATGFIILLASSRCISGLPFTTGGTEDVSHREPVLSHDISWPNLGEFHSKQVQLEGSSPILDPSAIWRRNSAGACKNLTDPKILPGWEKIKEYAKTHWGDKHHKVVTNDKDFPEFPALMCTPTTQSIQMSYSGKPLCTTNNVTSAGVLSGTSGTVSVSVGQGFMVSSTFALSSSTSFDLSDGLTPMINFPDVVGIMQGFSTNALISNTKSDTLTKTYNDMQTTTLIMASLEGQKCDATVEIRTCLLQGIGELKMVGTGFVWFQYEDKVKGHYKYREDIEKIVPDLEGRTTTVTFQGPIKVETHAAYAGSCREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0V5</accession>
    <name>A0AA38L0V5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_344689</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0V5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3788948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="111" mass="12849" checksum="0837CB48C95953E5" modified="2024-01-24" version="1">MSQYALVPKSELDEAQLRQLEEHEISQGPLSVLQQAVRNHAQVLISLRNDKKLLARVKAFDRHCNMVLENVKEMWTEIPKGKNKKPVNKDRFISKMFLRGDSVILVLRNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2I0</accession>
    <name>A0AA38L2I0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_298619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793506">
        <property type="protein sequence ID" value="KAJ3782017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2I0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="696" mass="73500" checksum="1F7786C5F9A9EB62" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2Q3</accession>
    <name>A0AA38L2Q3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_275825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793485">
        <property type="protein sequence ID" value="KAJ3782302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2Q3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="307" mass="33919" checksum="8AB3244686519AF1" modified="2024-01-24" version="1">MVLVDEEGIVCAALAGGPQGSDWDAVASAAAEAVGAAYDRMTFTEKQQTSRRGKFASCTAGYSYGGGRETVGNVHISGKKNKEAMDTLMHATSIQRIVGFTSDMFNTFAHKPYMEYKKTAEELQKQHPYLCPTSLQTPFAATTFNLGPQSFSPPHTDEGNNACGWCVVTALGPFDPDKGGHLVLWNMKLIVRFPPGASILFPSALVTHSNIPIQPSEKRYSMVQYSAGALFRWRSNGFKSDKAFLSSATSAELEKREHMRRLRWKTGLDSFSRWVDVQNGNWKGQDVEKALSPSVDHLEPPTKRFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3S2</accession>
    <name>A0AA38L3S2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_377002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3S2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041271546" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="2">
        <location>
            <begin position="266"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="677" mass="76346" checksum="FE26CB01550F0DB3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3U1</accession>
    <name>A0AA38L3U1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_364198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793487">
        <property type="protein sequence ID" value="KAJ3782275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3U1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
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    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ3782275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="505" mass="54764" checksum="6626DFC998BB8996" modified="2024-01-24" version="1">MAATAVSSSSTLWATASKDWVIQPKPKPGRKPKKEVVIEPVEDPDGKGRRVQNRAAQRAFRERKQSQLAELQARIQLYEQGEIERNVALQNIAKRLKEENEVLRRDNAVLKEKLDAAEQLLSINDKRHWRDDSPTSSISCVAPTRKRQRLDDGVQDAILSHMTTTFSSASPPSMASSPGSNDTSDSPFSPIPMDNHLSHSSLLSLSTVDKYDNYADHSVFMSCGFCSEHLPCVCREAFPSSTDMVPKTEVFETPAPGIIRIGSPTPHTTPSILDELPAYQPAVPLRRRQAAASTPVKPVAPVVAPTCSGDPRNCLACADDSFGKAFCDALGKSVAAQASSSSTSSENLSINPAEVSLAAGGSHQSISLQPEGESIPTNNAWEQLKSHPNIAFSDLALLADVVARRSKCSGPRVVISPAPGSITPERIASPDPLVNFTHEKTGDSEAVVLTDPHALFREQKKARSSPPRLVPQEVLMQRGQERLRQVQAAGVREALRLLDAKYANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L498</accession>
    <name>A0AA38L498_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_12630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L498"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <end position="835"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1128"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="211"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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    </feature>
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            <begin position="1131"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1150"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1166" mass="123923" checksum="9A077716AA4478F6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4C5</accession>
    <name>A0AA38L4C5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
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            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_387669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="MU793350">
        <property type="protein sequence ID" value="KAJ3785182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4C5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5041495370" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041495369" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="237"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="468" mass="50149" checksum="4CD1982F46A0AD95" modified="2024-01-24" version="1">MSRLVFKRFSSTITIKSTPSKAHHHQPITSSSFPSGFILTGLHAGVKKKAGVLDVGIILSTSERPTSAAACFTRNAFKAAPVIISEQILGENAGRARAVVVNSGCANAVTGAQGIEDAWAMAQETDALLPQNSSSQHSTTSQTLVLSTGVIGQNLPISKILSAIRSQRDEKQQTLGNDFDSWERAAKAFMTTDTFPKLRARRFSINGVEYRMAGMDKGAGMIHPDMGPPALGPLHATLLGCIMTDAAISPRSLQRALTYAVDRSFNSISVDGDMSTNDTILLLANGAAAEKNGVRLEEIDEETDKEAFEVFKKELTDFTVDLAKLVVRDGEGATKFVTVTVKGAPTYEDAHRVASRISTSALVKTALYGEDANWGRVLAATGSVSLSSPLHPNKVSVTFVPSDGTTPLPVLVNGEPEKVDEKRASEILSLEDFEILVDLGGGEGAEAAQYWTCDFSYEYVRINGDYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4K8</accession>
    <name>A0AA38L4K8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_312598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4K8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="709" mass="79021" checksum="469C143878143B5C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4R1</accession>
    <name>A0AA38L4R1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_359454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4R1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="124"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="266" mass="29802" checksum="073538913A4B31F0" modified="2024-01-24" version="1">MAPKKSSKKPAAAPLSKGKHGKTKNPLFEASAKNFAIGQDIRPQTDLTRFVKWPEYVRFQRQKVILNQRLKVPPGIAQFSHTLDKNTATQLFKLFNKYRPETKVEKRERLVKRAEEIKDGKESKDETKKPHLVKYGLNHVVALVEAKKASLVAIAHDVDPIELVVYLPALCRKMGVPYVIVKGKARLGTLVHKKTAAVVAINEVRSEDQRELATLISAAKANFTDKYEEQRRVWGGGIRGAKSANMLRKRAKSMGKTISDASAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L644</accession>
    <name>A0AA38L644_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bestrophin, RFP-TM, chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_345939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L644"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="428" mass="47993" checksum="8043F2FCF48C5C05" modified="2024-01-24" version="1">MSDTGTKGSAKRTLTSVFPSLRPKRKHLRKYSWLPDVFRIKGSIIRRIFWPVTTNTLFATIIAYAWHNGRRIALTNSIVPLLSVVVGLILVFRNGSSYDRFWEGRKSFATVTSNVRNLSRQIWVNVALPPSDQEDTPSKKGKAPILTASQLHRVKSEALHLCLAFPFAVKHYLRGEDGLNWSDYHDVLPKNFARFDEVGYQKSKTDLTTSYNSISTKSSGRSSPDLGRGDATKRVRPKRSKQNLPSQSTPLLSGAVTHRTVEFRPFADDTSLPLPLIIAHEISRLLFYFRREGLLETVGPAGTNAMNALVQSMVDNMTAMERIANTPIPISYGIHLKQCVTLYLFALPLTLVNDLGWMTIPIVTVVAFTFMGIEGIADEIEMPFGHDPSDLPLDRYCLDLKEEVLYIIERLPESGEGIYGYDDGEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L730</accession>
    <name>A0AA38L730_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_345155</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L730"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="13">
        <location>
            <begin position="71"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3788845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="270" mass="29347" checksum="892F98AA68636286" modified="2024-01-24" version="1">MVDDPESKSNPNPYPITTSTSSFSPTTITTNTNHSTSPVTTTTTPTSSTLTSTHPYRTSRPSIVGPPSPLYLGSPYPIRLRGKVCRGFGRGGKDLGCPTANLPDDNDGTGTVTGVQAMKGKVDTGVFYGFAKVLSSTKSNNSNSNATSTSASVVSDSVHPMVMSLGWNPFYKNERLTAEIHVMYDYGVDFYGLDIKVLVLGYVRPELDYLSREALIEDINTDKRVALNSLARPDYAVFQRDPFFFEDDEEEEEGKGKGEDGVGENKEIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB40</accession>
    <name>A0AA38NB40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793960">
        <property type="protein sequence ID" value="KAJ3780046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB40"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="144" mass="16720" checksum="F5C73BFEC605D4C0" modified="2024-01-24" version="1" fragment="single">NIVTPHLYTDVDEFQEVIKFHENSLISLSRPYRGYWSNENKSSPPLKARVNLIGLSTNLQPPQFPKDDSNVSKKASPEEKGLRPCRHCGSGKHWDYECKYARQGVKRARTNHTVATPEEIQAQEEYDEVYYDISSDDEREKEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBB4</accession>
    <name>A0AA38NBB4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_321673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793721">
        <property type="protein sequence ID" value="KAJ3780496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBB4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="88"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="497" mass="55497" checksum="42C0BC13B0FD9A47" modified="2024-01-24" version="1">MSSPQSIEPVTLDDVLKPNQLFRHHRAVKFGHDFLQYYSFKKGFLNLNNGSFGALPKVITEACNELTAWQEENTDYYYRIGFIPPLIGVREQLAKLVGASDVDEIVMVANTSTGMGLVLRNFLWKSGDIIIRCNTTYGTVYKTIQYIHDTTPGVEISQFELLFPTTRQAVLEGWKEHIDKVKQSAPQGSKIVAVIDSIVANPGASMPWKEMVKISKDAGVWAIVDGAHSVGQEPLNLSTSGADFFVSSAHKWLNAKRGCAFLWFSKKSRDIMLTTIPTSASYVSPGPERPPTNIISQFQYNGTIDYTPYLSVHFALQWREWIGGEAAIQEYCNKLAREGGRRLAETMSTQVMDPDGEFTLAMVNVVLPFSKEFSATYDASVSTALRNKLLSQNMFAVTFYHQQLWWTRVSAQIWNEISDFEVLGKAFVSICSDIVAEHENAHIPPESKAESFYSYLEHPFQGAVAYDPEDGVGAHRPVTATTVVPVGYHTHLASIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBC2</accession>
    <name>A0AA38NBC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Photoreceptor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_279241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793713">
        <property type="protein sequence ID" value="KAJ3780526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBC2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="424"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="920" mass="99916" checksum="88B208E7883FFF7D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBD8</accession>
    <name>A0AA38NBD8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_137622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793674">
        <property type="protein sequence ID" value="KAJ3780676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBD8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="213" mass="23944" checksum="7DCFAA6A2D3AA7BD" modified="2024-01-24" version="1" fragment="single">MSRQTTLNTMGTVRKENPARLTGNSTTSNTQNNTNTNSNTTANDTKERMAREFFASKMTTLGAHPLETREDIYNIMLKATRLPKRDLDTVVKATEHGIALLKKMDEKRIQEETMEKITKTVELSFAKLDIPKQIQQQLSQVNDEINQKLESMITTIYGAGNKTTGKTSTNPDGGSYAEVARSNRHATAPIPQAMNRQRLKAHVEVKRRQVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC88</accession>
    <name>A0AA38NC88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_317353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC88"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="605" mass="68125" checksum="93B908971AC604C6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCY3</accession>
    <name>A0AA38NCY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_387430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="64"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="564" mass="61375" checksum="CD4D7FD96DB00620" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCZ5</accession>
    <name>A0AA38NCZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_354622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793339">
        <property type="protein sequence ID" value="KAJ3785536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCZ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="351" mass="38345" checksum="179FCB0DBEC1755D" modified="2024-01-24" version="1">MTPEETALLQEGGELFVRDFAYTVPLTLLYGTYALLAFQALYTMMKRRKTKFSWVLIALLIITFSVITTYFCLYEASVFVLMQTALVKNTDLSSLEERFTIASESIVGLDIGLMWLGGVNGLLYMSGDGIVVWRSWAVWNGKRIVVILPIFLLFATFAIFLTSSTMRTIAFVNPSIIEPDSLFGSLVIAGYTASIATNFTSTVLIGIQAYQHRKFMKKVGIGSSVAVKVLLLLTESGVLYIIFQIINLCLAFLDDGYNSSSPFNVASHIWGLLMNLVAATYPTLIILIVHHNRSISHLTDSSGSGSTLFGQTHISFAQSPAVNSTIAGQESGFGSSNERAPSGLVESKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND04</accession>
    <name>A0AA38ND04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_387307</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="74"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="668"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="642"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="642"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3785611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="823" mass="87637" checksum="24EB1410B294D078" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDP3</accession>
    <name>A0AA38NDP3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_308769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000498">
        <property type="entry name" value="Serine/threonine-protein kinase KIN28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="15"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="21"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3787576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="374" mass="42544" checksum="F1448A8E6B3D56DC" modified="2024-01-24" version="1">MDAVERENQDRQKRWAKEQKVGEGAYAVVYRGREFSTGRRVAIKKIKVGQFKDGLDMSAIREVKYLRELKHQNVIELLDVFSNKTNLNLVLEFLDSDLEMIIKDRSLVFLPADIKSWMAMTFRGLEFCHRNFILHRDLKPNNLLIASDGQLKIADFGLARDFADPGFKMTCQVITRWYRPPELLFGSRYYSSAVDIWSLGCIFAELMLRTPYLAGESDMDQLKTIFRALGTPTEQEWPGHTKLPDYVPVGQFPKTPLRDLFTAASADTLNLLSKCLLYEPRKRLSASEALQHPYFFAIPHPTHPSKLPKCTTQMAPRPLGEVDGNVDMVGSGPGVKAAVPNKGRLKRKITSPMDDPKTRSIARKLDFTKHVKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDY3</accession>
    <name>A0AA38NDY3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_426376</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="80"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="277"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3788251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="419" mass="45601" checksum="EC4C7405CE8B7C5F" modified="2024-01-24" version="1">MPSTSTSERTSLLPNGDRRNFSESDNTFLHRTSRLFKAEGEPSHQDSLKFFVFGSWLNILLVFVPLSIIAHNLDWDAALRFSFSFLSIVPLASLLGTATDQMSTKLGQTLAGLLNASFGNAVEIIVGIAALLQDQLVIVQNSLLGSILSNILLVLGCSFLAAGIKFQESNFQVTAAQASSSLMTLACITLIIPAAYNSVKPPVESLLANPLSADSSVIDPERWNGLLVISRGTAILLLGVYVAYLYFQLKSHSYLFQAEGDQEAEEPQMNIVAASISLFVVTVITAFCADFLVASIEEFADRYKIPKPFIGLILLPIVGNAAEHVTSIWMALKGQMELTIGICVGSSIQIAAFVVPLLVVIGWISHHELTLFFANFETITFFASVFLVNTLIQDGKSNYMEGLMLITLYLVIALAFWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHS0</accession>
    <name>A0AA38NHS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_299274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793535">
        <property type="protein sequence ID" value="KAJ3781652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHS0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="551" mass="62839" checksum="5557CEDB33256616" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHV9</accession>
    <name>A0AA38NHV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_364788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793503">
        <property type="protein sequence ID" value="KAJ3782057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHV9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="198" mass="22227" checksum="807A2CF230604933" modified="2024-01-24" version="1">MLTFFGAHSTHSPFYASKFYFILICGFLFSVLFATSIPVALSESLDPPILDTRDDMPITRIASVEFTGKRTYRTTEEDRRDVQGYTLMFLHAVLPVLDQNALSISVEHSSWDTGPKQSNPTRTNPEKFTMTLKPSSRGLANLVKKPTVYTAYFWLEDSVVNGYLTIPSGKEIVSSEARKKITGDETTIAEVRKGKLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI69</accession>
    <name>A0AA38NI69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_317484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793438">
        <property type="protein sequence ID" value="KAJ3783077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI69"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="271"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="448" mass="50216" checksum="D7FE3A92FCF4436E" modified="2024-01-24" version="1">MSVLNRMYRLSTLVRIPKIYEPQRQITVPESTLADFLSFSREQYLHDVRNDGGKAKEWTLVMGNEAGDLDTIASSIAFAWLRTKVLNQPSISLLQMDRKDLDLRAENLHALELAGVSRPKDQLLFVADLIDFHPFPSRKFALVDHNRLSSTFTPEERPVVVAIVDHHADENLYVDSAEPRIIAPSGSCASHITNLMETVDLPPELATLLLSAILIDTDGLKPGGKAIDVDRKAADYLAPKSTFASSVSALQINDTTPSSTLYEVDFIRSLSEELSTKKNDVSHLGPRDLLRRDYKQYEFILPWHPAKPTIRAGLSTVPVKLEEWAADGKLETEGDAWMKEKGLHVLGVLTAYRGATKGKRKREMAWLVRTVSPPTDGFDFDALMERLCSGLEADPALELKEHKKFVNGTLKDTHRTFPQLRVRIYMQNPHATRKVTAPALKSIMEAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ74</accession>
    <name>A0AA38NJ74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_399207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ74"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="461" mass="52395" checksum="343EFCE6793EE7B9" modified="2024-01-24" version="1">MPLILIHLPDDILFNVLNLLSPPDILLLRKTCKRLQALTTERTVWTNVYRNPEYFLQPGPSDSQTVPDLERVILHAHRWATVWTDFTTLRKRRPRFSTINLPDIRYLTEYQGQYLAIGTTTSLILYDLHVEKVISRHEISTKPFWLYIHSNTKDNDAAFYIPFARVLRNDASTLQLYVYTDVVINDYSEYTIAIRSCICKVDSLGNPSIDEIAGIQISRNCIAGIGYDFFLAQGESGDISLLYIPSQKLYTISAGTPVQQLTNVIFTPGYVLLIFTEYSNTVERKYLELYPLPDPMVIETGTHILPLHCGTLSMHFSEASFFSTDLSVDGNEIIWLVVLAGPQLWTLRISLQPDGTMDFHKPHYDTHHLPERTLAHAFDLRFTASSNSSRGRGIARVATPKLSGWLTFDVRRSIDGNVSIARTIVDKDILPSLLMYDFDAYQGLLCGVNDDDEVIVLKLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJL6</accession>
    <name>A0AA38NJL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">GGU10DRAFT_278333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793614">
        <property type="protein sequence ID" value="KAJ3781024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="55"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="218" mass="24476" checksum="E0F870D2A0BCBDF9" modified="2024-01-24" version="1">MSSLLLKPLNEMETLAQTLFLSLSPGQIKPPPPRVDAFLACDQALAAAVNLSYKHQVKQRKIERLKTEILELDSRWRQICIELETEKRVLEEMIEEADERLESIEQAKKASIPYPELLAYAQSLSAFTSAPPNMPDLTLPGQPPPPHFFPPFPNEEKMRRGHLNAEAPLGLLGETHSVGRAPTVSPTQNLEPGINPYRHDLRGPSQFFDLDLDLNPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKU3</accession>
    <name>A0AA38NKU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_360422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793413">
        <property type="protein sequence ID" value="KAJ3783573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKU3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="82" mass="8477" checksum="A1AAAA2FD611E3B1" modified="2024-01-24" version="1">MAASRSPGLAIAAATAISISAGAMFVMQKDVKRKEGQASIFQPGDSDRTVGKAGDEHLSSTEVSEVVSQRASRGSPTNGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL15</accession>
    <name>A0AA38NL15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="57822" checksum="A53553C7D35B13AA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLV4</accession>
    <name>A0AA38NLV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_395247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP" evidence="1">
        <location>
            <begin position="65"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="297" mass="32598" checksum="A701D898171E6A68" modified="2024-01-24" version="1">METIESFALSATSESPLTPTRTYNGGYTEAKDIRLRLANGGAGQSGLIGAFANAFVKWCVGWYLADTTQSLAYLSSSWVDVAFTYNAAAEMALVRNGKAIARELVFLDHFYLVGPPSNPAQLSPQDLVQDTFAKIVANGALDALVCERPPTRFLSRFDKSATNIKESDLLIGIGQVPWALPPAVWYHVYPRFPIEALKAASVLQEYTLTDRGTWLSSDKKVCDALTVYKDMAECKNNNNLEDDKVLLNPCNALLGANPLDKDLAAKFMRWLLSPLGGQKVVREFKTMNGQMIYAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN91</accession>
    <name>A0AA38NN91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_127571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN91"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7053" evidence="9">
        <location>
            <begin position="13"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="473" mass="53184" checksum="E1C5703A8143AD76" modified="2024-01-24" version="1">MVGWPFFLNYNKTHSKTLPASDISIDDVLHVFHDPPALAGLNPLVTKCEALDPSKPNFYTIHDDLRIFGLFKVDTVYTVNFSPTNDGTDTEVNAGLGTTLSQQWRVKEKEESQEVEISERVTVRCIFLLLPFILATITGAHSRLLEALTEKVIAEAKARTTAKWDLPVYGTLKLNHLSYIREYHHHRTFALQSCAHSDNDPYGLFHLSLNKRPGEDENDSPKTEWLNMGYWKDTNVFPDACQALALKLIQAAKCKEGGSLLDVGFGTGESLILLLTHPFVPRPGQLTGITSLPLHYERSLERVKRFAPATDTKISLHAGDAVYKQESSATDHPLNPSSSARFDSILALDCAYHFRTRETFLCQAFRQLSPAGRIALADICFANELPMNWQARVVRRVLRLMPRENVISINEYVGRLEQIGYEDVKVEDISEDVFPGFVSFLKPRGLGWWIFGSVLCCYYKAGARFVIASGSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NND3</accession>
    <name>A0AA38NND3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_415415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793693">
        <property type="protein sequence ID" value="KAJ3780590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NND3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="574" mass="64493" checksum="879B411DCAEE7227" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NND7</accession>
    <name>A0AA38NND7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_139217</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU793690">
        <property type="protein sequence ID" value="KAJ3780605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NND7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="57"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="238"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3780605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="399" mass="44915" checksum="93F0895D987B57B9" modified="2024-01-24" version="1">MKAEDNVQNADNVNQIIESNWDEVVDNFDDMNLNPKLLRGIYAYGFERPSAIQQRAIMPVIKEHDVIAQAQSGTGKTATFSVSILQRIDPDLKTTQAIILAPTRELALQTHKVVVALGDYMDVTSLACVGGANLREDMATLRSGVQVIVATPGRLLDMIKRGAIKSDHAKILCLDEADEMLSQGFKDQIYEVFQLLPGDMQVLLFSATMPSDMLELSSKFMRDPIRILVKKDELTLEGIKQFYIAIEKEDWKLDTLCDIYDTISVSQSVIFCNSRRKVDWLTEMMESREFTVSAIHGDMDQKQRTAIMSSFKSGATRVLITTDLLARGIDVQQVSLVINFDLPVSKENYIHRIGRGGRFGRKGVAINFVTDRDVATLRELEKFYNTQIDEMPMNVADFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNT0</accession>
    <name>A0AA38NNT0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_234022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNT0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="67"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="224" mass="25545" checksum="F6BF0AE1C86DB068" modified="2024-01-24" version="1" fragment="single">PAYSSRQNPWNSQDSPRLPPTPLLRPVTLPDTDTNVFMSQTPYLSPNQAQIHPALRIASSYEPSLCIHWDILHPPRTSTIHDHQASLNTARLDFNSSAAIPSLYRIHITIETPELKVWMQQWGAIHVTSSVNTYVTLGDVLRAIYEYFHTPLTQEDLTAISPGPWRGILEQARRKRFRSEQVISGSVREREFVRADLLNGNSLFAGLRWNEESGRGYCWELILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNY4</accession>
    <name>A0AA38NNY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lccl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_298504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793502">
        <property type="protein sequence ID" value="KAJ3782060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNY4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21063" checksum="3CADFC371233FCBA" modified="2024-01-24" version="1">MAVPAEFTTLDISGKFVMNKSLSDSTEEILRLQGIGWFKRKIIANGTLYLSIKHYKDDNGIERIDIDQTLSPGGMGSREERILDWSERSKDDSLFGAVIGRSRRLRIEDIDDDYLKTGWDSTEHGFIQSYVSSDTPKSGTSWIANQIWGVEVIDSVRRYVRHVFFTGPQGEEIRGRLVYDYTGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP03</accession>
    <name>A0AA38NP03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_81937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793482">
        <property type="protein sequence ID" value="KAJ3782345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32475" checksum="C59E60D991F43A54" modified="2024-01-24" version="1" fragment="single">DLLSQKQSIENYIDAHKSLLSPVRRIPPETLAEIFIHCLPTDSLYAVRNLAEAPLIFTTICHDWRQIALNTPRLWSSLHFFLPTHLSDDVFFRRMAGITLWLERSGSLPLSISFHEGYENDPLIIPQSRPAMMVSLIRSLMQFSDRMQDVYLSLSSSSFPIFENLSPSFPILTSLHVHDKGFQTHEMNGIRSVGFASLLHRMPALEKLELIGLQTRFGINYRSLPCNWRLLTELVIRPLPLDLPQVMSILSETPRMQSVSVCISLDTSTASHYLVHLSNLHKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP23</accession>
    <name>A0AA38NP23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_396743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793462">
        <property type="protein sequence ID" value="KAJ3782645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9093" checksum="A6A850A96BD4A86A" modified="2024-01-24" version="1">MLAQMAATAGSVAVGSTIGHGISSMLFGGSSAPAPSVEAAQASSVPQSRAGINCDVQAKDFTQCLEKADLPSCTWYLEQLKACQAAAAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP44</accession>
    <name>A0AA38NP44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_436280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793444">
        <property type="protein sequence ID" value="KAJ3782960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP44"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041379922" evidence="2">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="201" mass="22681" checksum="06650672B50E823B" modified="2024-01-24" version="1">MLFSISYVLLGLVAVIHAIPVNSGITYSSGQTAPPHPPHAVSLSDPRHRQPQPQPLPQDEINVLFVYPERTGTGCPVRIIKQEINLILAEYRKHINVNKPFRFSLLNRYDGDIKNNLHDFIFWGEGMSGDCQTRENPCSVQYVALSQLLREPRPTTRLLTISNHIMNDVLDLTYALRDKLKGSVHPVSDEILAPLWPDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPG9</accession>
    <name>A0AA38NPG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-Cys(6) binuclear cluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_270569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793362">
        <property type="protein sequence ID" value="KAJ3784835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPG9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="611" mass="67479" checksum="56BC95D44C3F8022" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ11</accession>
    <name>A0AA38NQ11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoporin subcomplex protein binding to Pom34-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_138829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="10">
        <location>
            <begin position="686"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="9">
        <location>
            <begin position="1475"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1939"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1954"/>
            <end position="1963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2027" mass="224558" checksum="3984FDF2BB183777" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ93</accession>
    <name>A0AA38NQ93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_82381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ93"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="721" mass="77689" checksum="D0475F3F9C016A52" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQK5</accession>
    <name>A0AA38NQK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_59155</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041284836" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="22"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="89"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="374"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="716"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3789309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="972" mass="109435" checksum="F0E582233E9AC767" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQL9</accession>
    <name>A0AA38NQL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQL9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="316" mass="34678" checksum="1FF786F358F10953" modified="2024-01-24" version="1">MTPQEQAQLSAAAELYYLDVINIISTGVGIGMFGIGFCVAVWYLSNSRWGHAKVILLSCCLVIVLCSCWSLAYFGSYTLSSIWLVFVDQSTEIDLTTSIILDYINSWLPSVALVTGDFIVTWRAWVLLENNHYLQLILAVLGVANLGTNIASCIEDSIMVKSKLIKTISLLDWLSNACSIALNLCATSLIAWKAWTHNHTVKGSLHQKKTYVQKVLLLLIESGAWFCSIQLTVLVFTLVSIYVSSAGSLGFQEAFAVISAASTFAPAWYPVAVIILIQSNNSPIVETLHNTRSGRYLSDVEGNIEEASNMEQGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQT1</accession>
    <name>A0AA38NQT1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_404825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQT1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="684" mass="73618" checksum="878E7B0E5D3C9588" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQU6</accession>
    <name>A0AA38NQU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tho complex subunit 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_343301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQU6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="124"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="35817" checksum="000B5612210F9035" modified="2024-01-24" version="1">MPAFTEQSPSNGMKVSARPQATIPPLTLEEEERIVNSRITNDERPIKRIIKKFHNYINVTHTLSISPNVSTDNDNEAAEDAREAFLVELASFQLLLKKNAMICEAEARQVEEYQREQHRIDLEHSTLRGQIEQLKTALEEAQLTRKRKMEYDLIAEKVNTLPTREELEKTIEALENDMTAIRDEHETQTRAIQSQKAALDDIISDLGSLRFHGGDPTISGMPSRRGTPTTESRASEGAEELETVQPSEINLALSKTEEKEEGEEGEEKSLESEINGDIEMGEVEEDTKNSRARKVREDLEEGEATDASSELSELADDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQW0</accession>
    <name>A0AA38NQW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">JAB1/Mov34/MPN/PAD-1 ubiquitin protease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_48730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="307" mass="34395" checksum="1202AD43EEF2C107" modified="2024-01-24" version="1">MDNDFGMMMNARGGMQNRGDGTVPDNGEVIHISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTIQVIDVFAMPQSGTTVSVESVDHVFQTKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSSVDINTQQSFESLNSRSVAVVVDPIQSVKGKVVIDAFRLINPQTVIAGREPRQTTSNIGHINKPSIQALIHGLNRHYYSIAVNYRKTPLEQAMLMNLHKRNWTEGLKLRDFNLHKEDNEKAIKSMLTLSEAYNKSVQEESTLTPEQLKTRHVGKQDPKRHLEDAVEKAMGDQVVQNLATMLLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRG8</accession>
    <name>A0AA38NRG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_342368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="184" mass="19800" checksum="E6A2A1D981216380" modified="2024-01-24" version="1">MQDPATVSGNASDDIKQFLVDPLLSFNTLIEGKYRTTFADGVVNRITIDEASLSQQGHSHSKEARVICSIRVAEDMIDGAGILHGGCSALLVDLCSTLAMAALQMYITGKPVVTVSQAMNVVFHAPADLGEDLRIINTSVTTGKRVVSAKTEIWSVTHRRILVSGVHVKMTPTRKPRAVVTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRH7</accession>
    <name>A0AA38NRH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_26144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="392" mass="43473" checksum="B5E1F82BD2478536" modified="2024-01-24" version="1">MHLLHHQVQDKPVEKIQPQTNNLSEAQDEHIAKGLESMVAQSETNHDVSHGIHMHGKTVLEVPWIHKMIPGIEKLAANYHIGNFVVVRESGERIFESMPIYARIGMHLLFYGSARETVLNYRSVEHLLQEQSIKQGTIYNNPESAKSIPSFVQTYSLDITELLEPDLTKYGCFNEFFFRKLKPDARPVENLENPKGICSAADCRLTVYPTLSLACKFWIKGDEFSIPNLLQVPVDSPTAIEFDGASLAIFRLAPADYHRFHCPIDGVVGEITNVPGQYYTVNPQAVNEPKFDVFTANVRSVLYLTHSATGKRVAFVAIGALLVGSIVWTKGAEKGTEVRKGEELGYFAYGGSTVVALFPKGVVEFDQDLVKNSEEPVETLVKVGSSLGTSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSC0</accession>
    <name>A0AA38NSC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_303259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSC0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="247" mass="26940" checksum="F6AB24858A31A630" modified="2024-01-24" version="1">MSVSTPLLDTIEPDEPPVKLSGNISSAKAGQNARKPVVLTPTNRTQGSQMATTQSDAESGIAGIFRQSAHPMALFFLYFFRISAITIYVISGFLTDNYVLSTVMVVVLLAMDFWNCRNVSGRTLVGLRFWNQVDDDGESYWVFESRDPSRPANSIDSKMFWIALYVFPALWTSLLVVSILKLGLAFIPIVILALVFNLANAIGFTYADRDAKQRWANSVVGGGWGLGSLGGQLITGAVQKGVGRMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSS9</accession>
    <name>A0AA38NSS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_258385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSS9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="426"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="784" mass="89102" checksum="BA9BFDFC0492DA9F" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTF4</accession>
    <name>A0AA38NTF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_339625</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTF4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="488"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3790831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="913" mass="103585" checksum="C6F02FEA1CA351B0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTH8</accession>
    <name>A0AA38NTH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_370729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTH8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041299436" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11569" checksum="F6FF88C977DB35A8" modified="2024-01-24" version="1">MRFFIVFTTLLLSTAIAFPVPGDGKSPVHDADVALRDINSEVRGSEGRTRHGRDITDDGDFEEDFEEDNDSLARRNGIMSIIKDGKINLTQRLEYHIQNIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTL9</accession>
    <name>A0AA38NTL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cyclophilin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_281259</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTL9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="14">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="276"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3790880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="514" mass="55794" checksum="C2002801F217172D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTP2</accession>
    <name>A0AA38NTP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_103663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTP2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044617">
        <property type="entry name" value="TCHQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="358" mass="39530" checksum="64337D80D0BCE5A2" modified="2024-01-24" version="1">MSDVPKAVLYYNSASIWSFVVLLALEEKGYGKDELDLKAVDLAKGENFGPKFLRINSKATVPTLVVPLDKSLSVEVESRYKAITESKAIVEFLDKSRSPLSHTHTTSDAPAPILTPATIDYTATCKVIIEDLLHSDDADPNKLLYMNARDEESLRALADSLIPLMKGKVDALNHCLSDAQAGNVRASEKVVKFWTSKKEAAQMLLEVYEKAKVPEAELDANAKAHRAEFFKVAKAAWEVGLVHVLTKLNELIIAPYALGEQYSIADPHLTAWLATLILLAGGDANDNGNVAIEKLGKHIGSSLVLSKVVASEAPRTDVERTSARTKLGLYWDTVRERPSWKKVYGNRVNLDLYQKRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU61</accession>
    <name>A0AA38NU61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_338174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU61"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3791212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="357" mass="40549" checksum="9D6004B2D9BD26FD" modified="2024-01-24" version="1">MEALLFNVDSGFLEGTVRGYKAGILTQSHYTNLTQCESLEDFRTQLSATDYGNFLANESLPISTATIADKATQILVDQFKYLRNNAVEPLSKFLDYVTYAYMIDNVILLITGTLHERDTHELIERCHPLGIFESMPALCVASNVEELYQSVLVETPLAPYFRDCLSASDLDDLNIEIIRNTVYKAYLEDFYAFCGSLSGPTADVMQRILSFEADRRTVNITINSFNTELSKEERAKLFPAIGRLFPEGNNQLAKADEIDQVRLVCENVGEYRQFFADTGSSANGPGDEDSGVLSQLEDRFFQTEVHLNKMAFLQQFQYGVFYAYMKLKEQEIRNITWIAECIAQNAKDRIQDFIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYF3</accession>
    <name>A0AA38TYF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041208714" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7831" checksum="52D45A031524FEEE" modified="2024-01-24" version="1">MASRQGQFCLTALKVTLFIPWLIAGFSSNANIEPRLCQVRSVSGRFAMITLRNALQQTDSIGNDISYFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYT7</accession>
    <name>A0AA38TYT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_401955</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="15"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="382"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="11">
        <location>
            <begin position="584"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="1225"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1090"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1587" mass="179944" checksum="D63A2FF46AAF22D4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U061</accession>
    <name>A0AA38U061_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_430984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U061"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="466" mass="53003" checksum="A00684FA38FAF0F4" modified="2024-01-24" version="1">MAESIANSVPEVVNVVVSLPSELIHHIIEYLAYTPRPPHSYSRSQFKCASPELLALSAANWRLRRISLPFLFANIRIRHTKDAEEFQDLLAVLFQKFTKILAISYFYSRTKEGNQIVCQLLPHLKQLSCVELRCCNARSVLFKAILARPTVLSVLVEEQPDASLYDDLSKVVLVETSISATSSPNLDKCLNLGMRLGCLELVNLDLLDDNFGQRHFAGLEELILRMRASHLSFSWLSALSSANPALKEVWLIDDELCYFPNHTPTFISSFVEESQHQDLSKNLTVQRVGLRRSTVQDWHVIGLTISTTSSLVEILTLIASSFPKLETLTLDLYIHADTYDADDLADVLARFSSLQVLHLHHIFKRIRFESRRCVTPLRDANRTSTLDTLAARAESGLLWFTSRVAKRVYKRHGRGSRWYLEGWLQVLNNRDVDGVLRRCMDGVVYSDFRSGSRMLSHRYKMGSFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0T9</accession>
    <name>A0AA38U0T9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_147171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0T9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="128"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="338"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="631" mass="69564" checksum="2E6BDAF652F30A0C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1S5</accession>
    <name>A0AA38U1S5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Camp-dependent protein kinase regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_383205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1S5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0114">cAMP</keyword>
    <keyword evidence="3" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="267"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="422"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="641" mass="68494" checksum="25FDD116E62EA4B2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1V2</accession>
    <name>A0AA38U1V2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1V2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3791264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="502" mass="57487" checksum="311DC38622B4C77E" modified="2024-01-24" version="1">MPRLPHPDYPALKLPHFERIDEYQAIWMQHWEEPIQYEDGGQSIKVNKLLAQQSGKVWRLMDYERITGILEGSHTNGLGGCLLIGSPGIGKSTYLVYHLVQRLSQGLPTYFYDGLTIYFDATGAYVLHFNSDSDHAPFLKLPPTMFLVNSDNKPVPSRLWQSRVSLFIVLATSPKQSRFKELEKYKMMRRIIPKIPSFEEALQVWGIPSNSSKVPLLRLGWKNYGPDFRLGERVINLGEEVFIEHEKQIADALAPLSYSQVVTLISNADITNVSHKLVHSFSTDAHPTILEHRIHSGLILRMILHASTTKCLEDRESLFDLFTLEPKLAPSLGHLFEIMSIQKLAGNFHGVLKSLQGELTLDIHFESLPIQLFDNQSATSHTMAHGKFYIPRQKTNKAYDAFRYNGTTGYGFQKMLRDNHELNSEGMLDLCKRMEAAGMLEFLMVIVTPMNINFQLPKKVYHLQTKLQIKYYQVELDLGHQNNWLFETLTDNVDWDSVIINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U290</accession>
    <name>A0AA38U290_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_339400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U290"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041296919" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10284" checksum="3F35FEDE7234030A" modified="2024-01-24" version="1">MRLLGEIAFTLLMVTHYLQTSRDAGPIMCTLNLLEVREATPQGFKVKEPGKTYRKVFIVTASQYEESEWWKMNEESKLRTLSKVKMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U6U4</accession>
    <name>A0AA38U6U4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_425194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U6U4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="172"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32096" checksum="3592902F5DF01799" modified="2024-01-24" version="1">MSLIHSAAIAQSSFQTIPIINLSQISSNDPSIRRALAMEIRSACINVGFFYVANHGVPETLTEEFVSRSKEFFALPLESKLKESWKILLGNNDPEGGGDFQEGFEFTGEPFDSLDQTEIPESNFPYAIVNLGKLLFPIFALALDLKEDYFDQKTNNAAALMRSLRYPPQEELTDEHCFTILWQEPGIQALQVLNSDKEWIDAPPIPGDQFARWTNGIFKSTVHRAINRSNVYRYSIPLFMGANWDAKLEPIPGCVSPDRPLQYEVITAGEYVKVKLADTYKQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7Z7</accession>
    <name>A0AA38U7Z7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_241229</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7Z7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="13">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="59"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3790830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="188" mass="20711" checksum="66B442D2FC9FE532" modified="2024-01-24" version="1" fragment="single">MFSRLRRVPLQRCLHTQAPHTLAKARSVRLGFTLAASATVLSYTTWRWTRDQRIALDSVTASESTSAKTPALDGPSSETHHASASPSEKSESVASSTEQQQSEAETSDNASQGAYNPETGEINWDCPCLGGMAYGPCGPEFREAFSCFIYSEEEPKGINCVEKFQAMQTCFRAHPEVYADEIMDDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7E7</accession>
    <name>A0AA38K7E7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_5907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794265">
        <property type="protein sequence ID" value="KAJ3779754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7E7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="608" mass="68366" checksum="9C45741FCF26D2EE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8C8</accession>
    <name>A0AA38K8C8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_410456</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="MU793529">
        <property type="protein sequence ID" value="KAJ3781734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8C8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="81"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3781734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="490" mass="52860" checksum="6DDD446764AD3335" modified="2024-01-24" version="1">MDIGAGITTGTAELREATKMERIGVHSHITGLGLDDRLEPRPNSQGMVGQMRARKAAGVILRMLSPSSFSSSTVPAAPGLSGRAILLAGPPSTGKTAIARGMAATLGPDVPFTTITASEVYSLSMSKTEALTQALRRSIGVRIREEEEVVEGEVVEIVVERGITGSGKSGRVILKTTDMETVYEMGGKMIDEMTKEKVLAGDIISITKSSGRITKLGRSFSHSRDFSLLSPSTTFIPTPSGEILTRRTITHTVSLHEIDIINSRTQGFLALFAGDTGEVAAPLRAQIDVKVGEWREEGKAELVTGVLFIDEVHMLDMECFSFLNRALEGELAPLVVMASNRGVARIRGTEMRGPHGLPPDLLDRLLIVATSKYDAEEVRQIIKIRCQEEDVEVGPDAEDLLVEIAGDAGMRYALGLIAVSQIVARKRVKSSGGGSEVVEVEDLRRAYGCFMDPGRSVQWLKEQQGSLLVEEITVSENVRQGQSSDNMDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA49</accession>
    <name>A0AA38KA49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_387449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="196"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="861" mass="94756" checksum="C47EBA39624B3EC1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB32</accession>
    <name>A0AA38KB32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_386021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB32"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="139"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="321" mass="36390" checksum="8504F85F75BB2AB2" modified="2024-01-24" version="1">MTNFFKSIKSHTLTKNDEQDTRDSQPPEWAPAPEVSHTYGQYNEASDQEYRDGISYCLKHPLCLTSSIPSRFIDQIKSEGAKAWGLDIPQDHYRFSGRVDNIPPESKGQNLVHITTDKHCKDYCLLSNLPITAGLYDSSGREGVYFEVIIHEMNPPQSFLVIGTSCRPYPTFRLPGWNRESTGWHLDDLRKFFEDSDGGRNYTDNGHQLPLPWNPENRSEQYIPLGSTVGCGYIFKSGSIFFTYNGLRLPNAFDGVHLPRHERDVFAAIGVSGKTKFDVNFGGEPFRWVPGSTWQWRVEGLVGRLNSIGDECSERLPAYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC47</accession>
    <name>A0AA38KC47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_306233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="534" mass="60519" checksum="A7B3C746DFACD899" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCR0</accession>
    <name>A0AA38KCR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_400898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794510">
        <property type="protein sequence ID" value="KAJ3779621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="170" mass="18347" checksum="94B732196D7827D3" modified="2024-01-24" version="1">MYIGDPLVGAIANQYTSNRQMHDSIARQWTKLYAMPKPPPAASYSKAMTTLAASTRARGKATASSSATSTNTNPSSSSSTSRFALTGTQDTITVEDSDNEDGPQSMRTKAGAKRKQRSGASGHTNGESLDDDGEIEFVDEGRRRKWSTRATPVERGHHVHDSDVIVIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCS4</accession>
    <name>A0AA38KCS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_391449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794421">
        <property type="protein sequence ID" value="KAJ3779666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041320939" description="Secreted protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10444" checksum="5004F8234C7290F2" modified="2024-01-24" version="1">MQKVYHIFVLILSALTMTTQSAPLDGRRRALDPQLAHSESSRALNSNSLGSRQPPHMPLEISTTSVLVSRTWGITLKSLLDVSSRANIRKPVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDB8</accession>
    <name>A0AA38KDB8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family, N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_273834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDB8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.50">
        <property type="entry name" value="putative glycoside hydrolase family protein from bacillus halodurans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF0">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="23861" checksum="350872BE379CC449" modified="2024-01-24" version="1" fragment="single">TTMWFNSTNVIPLGNGRLGAQVLGQVPEEVIILNEDRIWSGSLNDPDNKNCAKALPAFREYLGLTVRPGKTISTTRKRLPMRNVWRHLSVNRCTKVRVYCTPLTKIDAYGLSAAGNLSLATSHSGIISNYNHSLDFTTAISTTTYAYEGVQYTRTAFASHPDKVIVIRMSANTTGLISFNASFETPMSMPVSAVGCIQSYAIQHSIYRHSLPMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDE2</accession>
    <name>A0AA38KDE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="7">5.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Myo-inositol 1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_391149</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="7"/>
    <dbReference type="EMBL" id="MU793684">
        <property type="protein sequence ID" value="KAJ3780626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDE2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="19">
        <location>
            <begin position="338"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3780626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="554" mass="60741" checksum="DA27E19B94027DAA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDV6</accession>
    <name>A0AA38KDV6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793544">
        <property type="protein sequence ID" value="KAJ3781571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDV6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="685" mass="76997" checksum="0B34AB3407EBF148" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE27</accession>
    <name>A0AA38KE27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_365042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793510">
        <property type="protein sequence ID" value="KAJ3781961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE27"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="86" mass="9350" checksum="99F38FFF815C7101" modified="2024-01-24" version="1">MENDQGVLVDLYVPRKCAATNRLITSKDHASVQIAIADVDANGRALPTTTTFALCGQVRSQGESDDSINRLATKAGLLRNVWSYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEH0</accession>
    <name>A0AA38KEH0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pheromone A receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_362717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793453">
        <property type="protein sequence ID" value="KAJ3782786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEH0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3782786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="576" mass="62867" checksum="42AB22EC89DC12D0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFU8</accession>
    <name>A0AA38KFU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_150400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="198" mass="22415" checksum="34660F374F53FE21" modified="2024-01-24" version="1">MAPLFQTIKSFNDVQISPEGVDTVDFLEATEGVVTMFDLFGSKIFGFIQSDIRGNIGGVRTRYQTYQDSSRTLEELVKSEGIHGDHRHGTACMVRLVRGLALIQHALKRMQEHPSDELHVCFKSAYDVVLKQHHAWVVRSVVTVAIRAVPHRRDFYHVISCGEPSDKFDPELNKWLQALEVIVGRMKDFLETGGYGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFX9</accession>
    <name>A0AA38KFX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_144561</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041352787" description="DNA-(apurinic or apyrimidinic site) lyase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="146"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3787438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="411" mass="46471" checksum="6804788B55E77C92" modified="2024-01-24" version="1">MTSLSTGFRALPLPIIQLSLAAVLKCGQSFRWTAYPLKLDPEDASSPTHEYRFCLRDRVVCLRQTATNILYRTVQPDPQPNANQRELRDAETLLWLKDYFQLDVDLAFLYEEWGSRDKVFLGIQDRFSGIRMLRQDPWENLISFICSSNNNISRITKMVQSLSKEYSPPLLSLPTPDGSGVEDTYHPFPPPSALAHPDVSARLRSLGFGYRAEFIHRTAKMLVETHGDSIQPQDSDEPSEQWLRTLRDISTEDARAELLKFVGVGRKVADCVLLMSLDKTDVVPVDTHVHQIAIKHYGMKGSTKGKMNMTPKLYEELCTKFVQVWGKYAGWAHSVLFTSDLKSFALHGLLEPTSPLPSPVKNRKKRSREMTDLVRILPTPPSTPSVSESATATEIACNLSPAERVKKRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGB0</accession>
    <name>A0AA38KGB0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_263769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3788023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGB0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="146" mass="16580" checksum="2FA934D0A563EBCB" modified="2024-01-24" version="1">MGWQQTFTLGRRSKGCHLITEEVCSQIQSGLKDVQVGMLFLFVQHTSCALTLNENYDPGWFLFWVIIDDMDMALDRIVPESLDWLHTDEGPEYYDIRVSHTKSSLVGSTVSIPITNGSLNLGTWQGIYLTEFRHMAHSRTVVATIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGR7</accession>
    <name>A0AA38KGR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_352349</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793318">
        <property type="protein sequence ID" value="KAJ3786296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGR7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="12">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="586"/>
            <end position="587"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3786296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="606" mass="66316" checksum="037731B4EC12C622" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHZ1</accession>
    <name>A0AA38KHZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_330665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20854" checksum="F709F5EB284DFC17" modified="2024-01-24" version="1">MTRGHPLSNDLREALVQMGHQLSVTKISQYTAISERTIQNVFSQFREKGYARRTKSLLEMRGAQRMFNADDVSRRGIDVNESTIWRYLQRRGYTMKKLSKTALERNEHRRTTFCFQFGQLVQPHKAVFVDESSFDRRTSLRKRAWALRGRKAERKWFFGHTSSWTMHASTKMIASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKG8</accession>
    <name>A0AA38KKG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_380990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793845">
        <property type="protein sequence ID" value="KAJ3780224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="963" mass="105476" checksum="EE7472E5DFF2443B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLA7</accession>
    <name>A0AA38KLA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_277647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793566">
        <property type="protein sequence ID" value="KAJ3781379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLA7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="100" mass="10627" checksum="AFE4D9A536848CF7" modified="2024-01-24" version="1" fragment="single">MVCRRTSLRAQVPPVNLKERIAALQQKNADQSQRPTSPPPTTAGSSSSVPQSNVAALREKIAKFEKKGGVPVPRGSFGLGAPPSDSGQSKTSRELYGNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN80</accession>
    <name>A0AA38KN80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_359674</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="114"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="385"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="772"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3783869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1172" mass="130918" checksum="F100CA73722B17F8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNH5</accession>
    <name>A0AA38KNH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_134161</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793657">
        <property type="protein sequence ID" value="KAJ3780771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="561"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="940"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1159"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3780771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1344" mass="151027" checksum="A324C8511F6530A2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP81</accession>
    <name>A0AA38KP81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein BRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_294836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP81"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="59"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="316" mass="36040" checksum="85CFE4F6D053D24B" modified="2024-01-24" version="1">MGSILKAQKANASKAARAVDRKGKRKADDMMAFDDSDSEFEEKQELEAVPATKRRKNKQRVLLLSSRGVTHRMRHLMNDLEVLLPHVKKDSKLDSKSQLHLLPELADLHNCNNTLYFEARRHEDLYLWAAKMPNGPSIKMHVQNVHTMDELKMTGNCLKGSRGLLSFDKSFDDTDWGKLTKELFTHIFGIPPTARKAKPFVDHILTFSIVDEKIWFRNFQIIEKDPLSPNGPPQMTLVEIGPRFVLTPIRIFEGAFGGATVYSNPEFITPAAIRTAIRKEQGKKYNIRKDAEQASSVRKEKRRRAEDELAVSKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPU8</accession>
    <name>A0AA38KPU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine-phosphotransfer domain HPT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_19447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="100"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="211" mass="23590" checksum="17F5BB8E4A6FDAA1" modified="2024-01-24" version="1">MPAGDKLEQSTSSQDTNKVTIESPSSVKASKVKADAHDPDSHADKIVISSTTANRPSSPPADPAKKQNTDTEAETSSSDQDEIINMSIFNQILELDEDDTHDFSREMVEEYYTQAAQTFDDMDAALMQKDLEKLSDLGHFLKGSSATLGVTHVQSSCEKIQRYGQLRDEEKGIDIDNEQALNLITQLITQVKGEYSVAEKWMRKWYTEHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPX0</accession>
    <name>A0AA38KPX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_291536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPX0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="75"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="268" mass="29077" checksum="3AC5E405D322DE51" modified="2024-01-24" version="1">MAAYLDVYAGDTIEHKKEIEEYNLARSLISTHGTVFNLPTLPELLSDEQREILQDLNKSSDHASLRFDPPTPLLLGRIIFDLDPSPGLNKTRQNFLSLCTGDRGLCKSAPNKKLHYLGCPIHRVVKGFVAQGGDVTRSDGSGGESIYGPKFPSEKAGLQVLPQRGSLAMANSGGKSPNNTSQFFIVLSSDVGVYSKLKGKYVVFGKIRVGDREGEQVLENLNELGASGKATDERPLVPVWIGGCGTLKEKICSIIDLSQESVQTCLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR55</accession>
    <name>A0AA38KR55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_394624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="110" mass="11904" checksum="EFB4FD7169576F0E" modified="2024-01-24" version="1">MSTSDDLYAVADFCLIPMGTGEPSVAGYIAECQRILEKSGLKYKVGYGTNLEGPWSEVSKAIHDCHLAVHAQGAPRIATDIRIGTRTDREIVPGTGNEAKVKRVEEILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRJ5</accession>
    <name>A0AA38KRJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ESCRT-II complex vps25 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_163835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRJ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="22012" checksum="C5194BCC58F8E405" modified="2024-01-24" version="1">MALSTHTTTTGFLLPSIHSAPPFFTQQPHPASLSIATEQWIQIILKYARHRRLFTVRVEDSEVSGNDWDEILRNERINRKLIPSYLSYILAQMVSQKLAVYEPPKQDRSILIYWRLPEEWAEVLYEWVSSSGNLNTIMTFYEITDPPVESPLSGLPIPLLRQAITLLSKSNRAQIIAISEGEGVRFFPTTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS06</accession>
    <name>A0AA38KS06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_399018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="MU793351">
        <property type="protein sequence ID" value="KAJ3785151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS06"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="32"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="127"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="358" mass="39285" checksum="0A96B38F67F0C0B0" modified="2024-01-24" version="1">MKVLAILYNGFNAAVKEPRLLGTVENKINGLHHEDTSSLHRKVSSDKEGPNSDFEKHIVDAEVLITTPFHPGYLTRELIEKAKNLKLCVTAGVGSDHVDLNAAVDHKIQVLEVTGSNVVSVAEHVVMNILTLVRNFIPAHEMIERGDWQVSDVARNAFDLEGKVIGTIGAGRIGYRVLERLVPFDCKEHLYYDYAKLPVEREEAVKARKVDDIEDFVAQCDVVTVNAPLHEGTRGLINEKLLSKFKPGAWLVNTARGAICDADAVAAALKSGQLRGYAGDVWNVQPAPKDHPWRTMKNPLGGGNGMTPHYSGTTLDAQARYAAGTKAILENYFESREQEPADIIVGVGAWATKSYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS33</accession>
    <name>A0AA38KS33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_333281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793348">
        <property type="protein sequence ID" value="KAJ3785256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS33"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041217891" evidence="1">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="149" mass="16459" checksum="B5692F0F0B0D4EB7" modified="2024-01-24" version="1">MKFFTASLSLCLVSISQLVFSSPILVSRAADSELDVWSPTITYPKGEHIVWESGLTVYNMTWETADIPERAQNNTGIIMLGYLDDDDDSSDEHLDWKDPLASGFAIRDGIAYFTIDPARNLTTMDSYILCLLGDSGNISDRLTIEAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSR0</accession>
    <name>A0AA38KSR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794418">
        <property type="protein sequence ID" value="KAJ3779667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="213" mass="23382" checksum="C3BF98C1A7DF462B" modified="2024-01-24" version="1">MSATWSPACPARSLSPVLNEEEAELQAYLAAAQREAQEKWKRLREEKALGGGAGECKIVEEKGVVEEHVDDVVGEETEVVPKVESRPQKVASKMVAGLPRSREVIPIILIPKKRRNVVEVEVAESSHKRRKVVQILTPTPSLSPFLVPASVAFVATRFVGLSPTLPTRSLVRGATLCGKVARSSRSRRNRGFDPHPMSLTGRRKESCVMPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSR2</accession>
    <name>A0AA38KSR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_311794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSR2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="454" mass="49725" checksum="AA68252821BED9A2" modified="2024-01-24" version="1">MSDVSVGSQIFDLVFHPSHATVYTGLLSGKVKAFAYNKNGRTKEVFSVKVSQKSCRGIAINEDGARLYTVGKGKGLNTIDTSTGKLVESRAKAHETAINRVKSVTSWLLSTGDDEGVVKLWDPRQKESVRKYTHHFDYITDFLWLDDKKHLVTTSGDGTLSVIDVRAKTSEPLAQSEDQEDELLSIVPIKSATKVVVGTQLGILSVFNRSSGWGDCVDRIPGHPHSVDALCVLPASLPNVDHTSTILTGSSDGFVRAVSIFPTKLQGVVADHGEWPVERIAVGEGLDQLTLNDSEEEAVQKPNSKKETVGRIQVDDPDQGDSDSESDESAEARHYWVGSAGHDELLKLTNLGHFFNGQAREEGVDERQDDEDTQGLLPSMSLDDEVAENAADPDRSLNDLDTDSKPKEPDTDSEAELEPTKSRKRKKKDKDPLSLKRKKGKNEVEVEGAFFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSY6</accession>
    <name>A0AA38KSY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_311415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041325961" evidence="4">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="380" mass="44463" checksum="9FC7E25AF4CE0C30" modified="2024-01-24" version="1">MMTPMRYVVLVLAIVISIHYILSLTHDGYGQATSISNLKSQWSAGRPPYKTPVPDEYYVSENVTAPSGRRANAAIVMLARNSDLNGIVVSMKQMEDRFNKKFRYPYVFLNEEAFTDNFKNRVTELTDAQVEFGLIPREHWYQPDSIDEAKASAARTDMVKNNVIYGGSVPYRNMCRFNSGFFYRHPLLDKYRYYWRVEPDIKFFCDLDYDPFLIMQDQNKVYGFTVSLYEYEATIPTLWQAVKEFIHENPDLVSPDNAMAFLSDDGGESYNRCHFWSNFEIGDLDLWRGESYTKFFEHLDKKGGFYYERWGDAPVHSIGAALFAKKEQIHFFNDIGYRHEPFQHCPQGEAHSKGKCWCDPAQNFDYEWYSCLARYDKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT59</accession>
    <name>A0AA38KT59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793877">
        <property type="protein sequence ID" value="KAJ3780162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT59"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="448" mass="48081" checksum="27DF8E85AFD3CCFE" modified="2024-01-24" version="1">MTKLVKPHPPSTPPRTNSHTNEFRESEDSKEPKESKAVAFPTSNTASPSSTPSKPSKFHRFSKLSTSSSSSDDTPEVHDALRLRKPSLLKTVKRVSSKQLRSISSTLTNSAHRITLHGHGHRIEHSSESSDSSQSSEPSYLSQSFDSSHLANSSHSSESSELSEVAESEAPSQDSRRRRVSLPSFRLLRPSSYSRSRTGSSVGSAPSSVAPPVPTIPANLGTGFERSYSSSSISTAHNDSSVLSPVLASPSSTATPNLPSPMVVSGASSADGDAKDSRDTLLAVGDDLYHETDAQETQSHPPGLSISVELVQTSEAAVDVEPAAQMPSGDQSVLGETRIPPATPLPSSFRSVSSISSFSYTLPPSCAPDYHSWTDDIDVDEDSEDEGEDEDENDAGSDEDINDKSIVKIDPHRVSKGPFISSIFILVPVLSVRRPIGFYLNWWLGRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT86</accession>
    <name>A0AA38KT86_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_386468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT86"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="578"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="811"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="519"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="1046"/>
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            <begin position="37"/>
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            <begin position="60"/>
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        </location>
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            <begin position="125"/>
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        </location>
    </feature>
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            <begin position="180"/>
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        </location>
    </feature>
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    </feature>
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    </feature>
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            <begin position="537"/>
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        </location>
    </feature>
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            <begin position="722"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119650" checksum="A231C1D2A8329B84" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTC1</accession>
    <name>A0AA38KTC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793766">
        <property type="protein sequence ID" value="KAJ3780372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTC1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="512" mass="57254" checksum="5816273731745088" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTN4</accession>
    <name>A0AA38KTN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_348980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTN4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="400" mass="43312" checksum="A6EB6FF07DD28362" modified="2024-01-24" version="1">MAFPEHSKHDKLKIVIVGGGVGGLGLLRCLSTTIDPKKHTVILIDARPAYVHLISSLRLVVSNTDNLIKRSIHPYGDHTFRNKLAGNGTFIQASVTDIKFNDTGKGGQVILDNGGIVVYDVLVLTTGSNLPYPIAFPTSTKAIEEYVKARQAEFAAATDILLVGGGPVGIELAGELRDVFPSKAITIIHRSSHLLNAVYPDKFRIAIQKQLQDREITVLTGDAITMSDTATSQVPKDGFITKQGKTLKPDLVIPTWGMRPNTSYLPSDLLSSTGHVKIIPTFQLPAHPDVFAIGDIVDWNERVNASKVVRSHAPVAARNVLLYLSLREAQGKDSIDILASKDSAKYKGTIEAITISNGKTSGMSYLDVLWGIMFGGWVTSLSSRDLAVSRLSYLTGYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUA1</accession>
    <name>A0AA38KUA1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear condensing complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_437061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793522">
        <property type="protein sequence ID" value="KAJ3781812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUA1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="568"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1040" mass="119854" checksum="860F3F6B732066E2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXT4</accession>
    <name>A0AA38KXT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_373359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="170" mass="18803" checksum="2F70F4EE73079A02" modified="2024-01-24" version="1">MVSEGLCSLSEWAQKRTAAIYVAPNKAQAKKAIEDLFAPHVKASINGRNITREEIDQLLLGMRPAEEGALEFFWTDVVATPKDPSQREGAVSGVYVIIGLSLPHPQTGELAPAFRRKGVAVIIESQSQDPMVDSRKIVEFVSVANNYPLDQLAAQERERKTFVSKYGYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXX5</accession>
    <name>A0AA38KXX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_396744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793462">
        <property type="protein sequence ID" value="KAJ3782648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1157" mass="131134" checksum="6F2822097512D256" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYE9</accession>
    <name>A0AA38KYE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_436040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="168"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="340" mass="37497" checksum="C4C5CA0C16505816" modified="2024-01-24" version="1">MSESLVSSTGPLLVGVALEWGLLGILGLQVYTFYTNSEKERLGIRILVYTLFTLSVTHSIIAFTWAWRFLVSGWGNPDVFLIVPWQASAHTILSGTMTMLEQLFFCWRLWAFNSKKLLIRCVVTLVIMISFMQVIASIYGGIRAAQSATTADIEGLNKIARVWLSGGFCGDILVATSMIIVLRFATSDAYSRRTQIVLQKLIVRSIETGSVTAIAALVVLVLFELFDTNYIYIAAAFLLCNLYSNVVLASINGRKSIASILTQGNTTLGYTSGRNDFAPSHELAFHRQVPATIGQDDECLDTTSFKTTSDPEHLDSPVTTKTVWDRVNVNKVCVNPVQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZ86</accession>
    <name>A0AA38KZ86_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_387802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZ86"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="385" mass="41564" checksum="A12821BE6198A7F5" modified="2024-01-24" version="1">MGSPFDFLPEELTEHILSLCVTAPFELSAPRLNWLAHAKSISSKRRDPATIRTRLAPLLVSKDFHRIAISHFYSTVHIGSSNQAAAFLHSLRERAHLIAPLVRRLVSAGIFPSLGAILQCCKNIIDIDFSLDSSPIPSGGVDFSLRQFCDALDDLERISRFTLRRAPNAYLTLPRTQYVLTRLAGTIENWRCLESANVAFRMSDDNPQALLALAYPLVSQSLLPVATRPLFVSSPVFTASPPASPSAAGPSPAHGGPVSLLTSALAKSPSLHTFTTHVPSVWNETILCVSQNPSLQKIVLGDPRTGVLITGLFMAEAKNHPRLVELIKAGTSMVRTRAHTLGNLGNGTPSSTSFTPKYQPNVNSGCTGSDRVLAPSRSNSVNSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L050</accession>
    <name>A0AA38L050_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_349504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L050"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="807" mass="90049" checksum="48B006CC1B44CA74" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1J0</accession>
    <name>A0AA38L1J0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794400">
        <property type="protein sequence ID" value="KAJ3779677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1J0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="508" mass="57398" checksum="71C9E4EF865E21C3" modified="2024-01-24" version="1">MGVSYLKEAMQATSHFQSDAHLQDVFDILFYLSCIKDRKHKAELFLPLQEFVHVRAFRKLGFRVYLFSTNWGKSPFDILHENQSTIATDPALTQTFTLALNPDVRYLVERAIGYIQLAAGSTRRYICEVNPGNLALWTHFLQFLWQKLCTILLQKNAKDEWKVLMQKPEAEAVSKLVSAIRTLYELRKSEERTAWAATSRGKGMDSDLLRCSETMSTYRFPLSPDAVKDVKHEPHLDESRDSAETLRQFDYAGLEGELYEEINDLEALPQRVMRSLATVWAWYLSADALFAERTVKIFDKKVELTRVQYKPFQAFCYDTTDLGARVLPGLFPKVTWTEEVTAELVRRTWGAKVHAEAALMGLALKKTLVCSHELHPPVFGSSEIPVGVGKKCCRLCWLLKERINSNAPDLTLILPGTHGIFYPWIPPAGISEEILKNLRDVLIEVIRDVINRDLLASHSQHSSGVDSESDSVGPPKVKASNLLEDLSKWLIRAPTSKGGGRMVLSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L329</accession>
    <name>A0AA38L329_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_396594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793445">
        <property type="protein sequence ID" value="KAJ3782932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L329"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="196"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="602"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="796"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="916" mass="103062" checksum="11F8024BF6E793E3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4K4</accession>
    <name>A0AA38L4K4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_354245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4K4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="294" mass="33067" checksum="14CF4C507C48A3E4" modified="2024-01-24" version="1">MTVHSIAQQGFGEGTNEVYDQARPSYQPSVLSYISQNIPTAKDHPLNVVELGAGTGIFTRALLAHSDLSSSIAEIRAVEPSKGMRNQFKKTVIDPRVNDDSKIKISIQDGSFTSTNIPSAWADVIFIAQAYHWAHPSYDAASVEFARILKPSGVVVYVWNLENSDVSAGGAKWVASLRNLYEKYEGDSPQFRLGLWRQTFDSNSCPEYARLFEGPIEESFQWWIPTTVEGVVQRVSSKSYIAVLEQESKDEYNKLVQNVKELLRREDVEKSWVDTEKGVFEYPYKSTVVVAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4N5</accession>
    <name>A0AA38L4N5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_434285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4N5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="281" mass="31429" checksum="55A240B7188DD4F9" modified="2024-01-24" version="1">MDLLFSSSPVQYPYSPSTPSSNRIKSYSLSRSNHKPLNSSPLAGNSSPMSSPVAEAQARRQSQYKSRVSSGSQRSRPGFAPNSGLMSRVAGSSSAGGTDSQNAMLRDRFKQRCLERAEKARAKAHAAKRRSGPDSDIFDAMDDDMEEDDEDVIQGEFYQRIMMNQARQQRHAYLRSYYAEVGSSFDPDLEDAAAWERELHAPEPSQAGQFSNQDIQETVEMTPEELEQAELEAYAEECERRAALADFEDIPFDELFDDEEVNESLAEGNQSHNGDDDMDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5N5</accession>
    <name>A0AA38L5N5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_138140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5N5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="540"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="608" mass="67959" checksum="FD1C3B4068456469" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5X6</accession>
    <name>A0AA38L5X6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_352606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5X6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3786160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="412" mass="46599" checksum="56A741EAFED7F6BF" modified="2024-01-24" version="1">MDEIGIEIQKHEPTFESVVTEKTALYQELQEEDLYTKYKKLSRHLELLEIQEEYIKDEQANLKRELIRAQEEVKRIQSVPLVIGQFLEAIDQHTGIVGSTTGSNYVVRILSTLDRELLKPSSSVALHRHSNALVDILPPEADSSISMLGASEKPDVTYQDVGGMDTQKQEIREAVELPLTHFDLYKKIGIDPPRGVLLYGPPGTGKTMLVKAVAHHTTASFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILIELLTQMDGFDQGSTVKVIMATNRADTLDPALMRPGRLDRKIEFPLPSRREKRLIFQTTTAKMNLGPDVDLEDYVSRPDRLSSADIASIVQAAGLQAVRKNRYVILPVDFEEAWKQTVKKSNETHEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L606</accession>
    <name>A0AA38L606_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_412322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L606"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="178" mass="20521" checksum="A3E213CFD2FAB2ED" modified="2024-01-24" version="1">MFETNNLRIRAVHNTDIIKLHDLWNDLRVQKTLTPAHVIPLGIKFEDTLRSWVSDSLLYCIIETKADSEWVGFVNFFNADKKNRDATLAIALCPEFWGRGYATEVLRFIVDYAFRELALHRVTLNTFGNNVAAIKVYRKVGFVVEATQRKANWSGGNWQDVVLMGILDEDWTASKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6I0</accession>
    <name>A0AA38L6I0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_142640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6I0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="483" mass="54915" checksum="85BD7BB342B63BF5" modified="2024-01-24" version="1">MIISHLLNEGIENMISLSLVSRRMRQHALPVMFRSVQWPKDRLQLIPSALWPYIKKLELMYKSDSTLKQPSWVFQSQHGRCMELLSKALPEMPNLVSFVYTPRLPPSLGFIKALASTSSLQSLYIPTSFLIHDALILFRDLHGVRNLVIEQVGQATLYDAPESKRALSVQCVANIVQGCSGTLEYLEIPGQYCPLSDLSQKISLPVIRMLVLTGFPPLESDSHNYPLWTIVQSMQKLNVLEVHCRLRIIGALPHRYELLPLNASQSQNDMFSSQLESITISNPSLSDQIFKRFPDSLKRLVLDFIPDSWQNMLQSGSDTVLAYHKPSMIVGLFRTLPSSRPNLEQLCIRMGWCVTTGLLECILYCFPGLRELELQGIRYFNRAEEPESDMAGIVVVLEKFEYLHTLKLAVEFKEDSYLESSTQARDIGSVETAMKGWANVLEKHIKSLRSLAFEKRRHTGKGYGRRAAIGTPQWVWFDINGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB00</accession>
    <name>A0AA38NB00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794239">
        <property type="protein sequence ID" value="KAJ3779776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="21852" checksum="963100206B647FEE" modified="2024-01-24" version="1">MRPFLWFLRENYLRCQKPKGYLEKDANGFARMRGGISLPDEDHYKCGPLKARFELYWRKNPTAKTWMLEPVSSSMSDEYAGVQCSQHTTYTLRGYQGPEMLAAAAMDNPGINESERDAVKALVLQMETRRSKRNRETLESNPQFSEIDPAPSAPIPTRPVAPTKPPKPILGKLPANYVPPQERSIGILPKDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NB26</accession>
    <name>A0AA38NB26_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_177234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794018">
        <property type="protein sequence ID" value="KAJ3779971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NB26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="846" mass="94207" checksum="3291E826A836BACE" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBJ1</accession>
    <name>A0AA38NBJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793579">
        <property type="protein sequence ID" value="KAJ3781276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="219" mass="25132" checksum="94EDD4BC4242C7AF" modified="2024-01-24" version="1">MLPDKFPYPLQGPSGRRGEKVFFHPGPTAIQWFGYGRQHALVIGIRNQDHPTLGFRLEGTFKDLYNQKREMFHVQKNNLYYAGTYRCLRIEQMITIPEIIESLDLSLIAKPFKADMIKAAMQAQRHRTPNDPSLRLDRMTELCLDGTIKFEWAAFQCVGFDEDVFRALGGRYVSPSVPIVEYVQKLLRESTNVLDADQSKPQLSEQDTDASIEVDEVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCA0</accession>
    <name>A0AA38NCA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_361421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="MU793428">
        <property type="protein sequence ID" value="KAJ3783256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCA0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="560" mass="62690" checksum="9AE99B4F432E7B7B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCR5</accession>
    <name>A0AA38NCR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_293530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCR5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="468" mass="50851" checksum="7BC12D1A033A1FDD" modified="2024-01-24" version="1">MARFRAHSLKVGNRVTDAAQLTLRETLFPLFLVTILYFLWGFAYGLLDTLNKHFQNTLGITRTRSSGLQAAYFGAYPLASLGYANWVLRHFGYRATFILGLTLYGIGAFMMWPAALKQSFGGFCGATFIIGSGLGSLETAANPYMAVTGPPKYSELRINIAQAIQAIGTVVGPVLGSYVFFDETGDSVNALKTVQWVYLAIGCFVFCLAVVFFFSVIPEVTDADMSQQADLTHGTKGDDEKPFWKQYRLFHAAWAQFAYTGSQVAIAGYFINYVTEIRPNTSSALGAKFLAIAQGCFAAGRFSGSGIMKFIRPRWVFLCYLSCVIIFCAASITQRGNTGLALLTMTLFFESVCFPTIVALGIRGLGRHTKRGSGVIVGGVVGGACIPPILASVADRRNSTAFAMIVPVMFFISAETYAFAVNFVPSYRDRADKIGESAVLKSDIEKGADLSEEGSVDDKAVVYEQENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDM1</accession>
    <name>A0AA38NDM1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ loop repeat-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_144741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDM1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000028">
        <property type="entry name" value="Vacuolar membrane protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="509" mass="56223" checksum="DF5FD91BAFF58F0F" modified="2024-01-24" version="1">MASLTDFSIFLGYLSIFCWLGAQFPQVLENIRRRSCEGLALPFLANWLLGDISNLIGCILTNQLPFQTWLAAYFVSVDFALVGQYVYYQHVNPPRARSRIRPTSVGDRPSPPYRRLSAVASNVAAAAALAAQHEEHNAPRRIHRWPQSSRETFLDSSASRISRDDGDGDEVNEGAFSALADSFHSEGGQTLGNKQVLWNMEWQRRGSSVGRYPALTQSAYLPPPSTFDNTADSTARGRTLQRDPGQGHMDRVLPSTSLGRGSRVSRQSASMVFLGVFTLFGLGSFSSPRHIISLSNASRNGRVLFPRAIDSTSTFSPTGGVTTSYIVDGFVSFNDSYTSISIPPTTGLPAFEPKIVDDSNERIIGRIFAWVCTTLYLTSRLPQIWKNYVRKSVEGLSMFLFIFAFLGNTFYVASILTSPDVYQPAPRSEDFIKESIPYLLGSGGTLVFDLTIVTQSFIYRSKPRRHRSRSRAAEEEGGLLAGDILAHPSQDEADVHSRTRTASRTRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NE89</accession>
    <name>A0AA38NE89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_409005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NE89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="192"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="319" mass="35824" checksum="F6329E452D952656" modified="2024-01-24" version="1">MSSSTSISGFTQISVSYSSSSTHYIFARAHTSSKKSTSSWPSGRTLFLVNVPPDATERDIILLLKPYGTVEKVIFDSDSPIQDEEDGANSDSEAEEVEEHEEGQHDNDDVDASQPRKRRKLTTKKLEPPKVFPLPSIPLRKLRKTGQTAHVIFLDTSSVDRFFSASHAKPRPWPSSSEEPSGLSHYLALYDSLRPPLDAVRQHANSAMDLYEFELAKSKRESKYKKGEAIVDEDGFTLVTRGGAYGRTVGGGVAVATKKFQETGETSERNKKPKKEKTSFYAFQKAEKQRDELIQLKKNWELDKAKVEKLKASRKFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH66</accession>
    <name>A0AA38NH66_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794252">
        <property type="protein sequence ID" value="KAJ3779762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH66"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="296" mass="33456" checksum="AE7CC2119E25ABCE" modified="2024-01-24" version="1">MVTTFPRDLCLRWVFQDPITGDAKVLYGRDTELRWSEVIAGARSAIVPARYVTRIAPDATLRGPITREWFLDMVSQFSVSKEGKLQRDGLDVAQIWEDFEWMATAMLPTVKDVNLSLYTPERLVKDVREAFHMWHLDSMNLDQLPRPSIPSSVHTSFMTLGLVLLFVLVDGSRRENVTNFIVNIITSTTIRIFWAMLGPNGWLSRPSDAAVVRTVRAALSNRGSWNCPGGIPPIWVIACGPRGNHPHYTIRLFYPHSPLAAFTIHQQQSQHQFFASGSQSLTFAAYNPLFIAQIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHE9</accession>
    <name>A0AA38NHE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_321759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793757">
        <property type="protein sequence ID" value="KAJ3780392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="449" mass="48620" checksum="478365B7BA48049C" modified="2024-01-24" version="1">MGKWTTGYYDDVLGSKIKSLVSGAIIRSKLEKTEPEINFERFVEELDAGDSFTTSLFDILVKELADRQSRSNVDDRQLIGERTAKSLRMITSSNRVYFSTSFSHRAAARTRSHLPTYLAAPPEEIDWDDEDELHALLNSDPASRRQHDVVTETAGATTALPSLATRSLSPGPITSTDEVPTYSPTWVPSRSYPNSGSSLSRSSSLRRPTRSRTVDFNDFTSRRRSTIRNYTESGGGGGGGNSASTDALTASDTRDRDNHSWVPIGSTRRFFGLSRIRRSNPELNLWSDLPESEDGLAGGGNPVLPYIPTSSSSTSPHGVILPSPSETDGQNVDSSTTSALNRVYPRAPRLRRGELRHPESSLSRQASPAETVVLPDDYGSSRRAPSPPEISGYVVESFDTPRFGLGALSSPPIQEGGGNFGEREVGATFGIVETAAYPTPGSPGSTVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI91</accession>
    <name>A0AA38NI91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_361219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI91"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54790" checksum="80301A329B48066B" modified="2024-01-24" version="1">MLNADLITLICGELESGTSRALHHEYRTRDDVDCRKGLLSLALTSKAFLEPALNVLWRKISSVEPLLSILPDIMILDGKKTIKLEQITPSSWDRLHHYARKVREFEEQDSSNVHESVYALLGQSKPIFPNLVELRPGLQISTNSLIFFLTSSISNVSIPWPIRMPSNTHDLGPSLALLASRNPGLKYLSISFVAVSGISSSLRCFRNLRTLVLGRLPQYEPDYVQILASLDDLTSLTLTLPRDDIFQYGSIQNGFPSLERLSIVGFTSNLRGFLKVVSSSILQDLSLRWEEPPALVADAFSVTNTLGRFSSLQELIIENATSVLVDDFDRRSDYWALFMPLLQLNQLRSLTYSSPLVLTDELMAKIALSWPHIVNLYFNAAEWLEVPPVSSLAHFVRGCQNLRALRCPIRVNVPTGTAPPEPTLFMHPLRSFHCSKHDDVLDPACLALALHQLFPGLRSVTGDGDGWDEVEAILKTYHFLLTQDRRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJD4</accession>
    <name>A0AA38NJD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_367091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793571">
        <property type="protein sequence ID" value="KAJ3781338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="14006" checksum="A5DB1BAEBFF73861" modified="2024-01-24" version="1">MAPTAKKTGKTRSALQDVVTREYTIHLHKRVHGRSFKKRAPWAVKSVTEFARKAMGTSDIRLDPKLNQAIWAQGIKTVPHRLRVKLERRRNDDEGAKEKLYVYASHVPVTSFKGLETVVVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJE9</accession>
    <name>A0AA38NJE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_312768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793339">
        <property type="protein sequence ID" value="KAJ3785537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041207375" evidence="1">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="312" mass="32509" checksum="CE424F1CD5FD1F51" modified="2024-01-24" version="1">MKTTSILACASLAAAASAFVIPQARDTASNSSTTINDTSILNLALTLEHLENAFYSGALSNFTADDFTNDGLPVWARGRFEQIASHEQAHVQLLSNTLGSSAVQACNYSFPYTSPSSFAALAQVLSGVGVAAYAGAAQYLTNKDYISTAASILATEARHASWIAGPVNKANPWSGPYDTPLTFDSAYTLGAQFITSCPSSNPSLPVKSFPSLTLSNTTLGQVSEVTAGNNVTVEGQYVAFFSGLSTTFVQVKNGQITIPSNGMGTSYAVLTSGNSSADDSTITAGVVVLQFPYDSTGGSETNARMDMAEDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKE9</accession>
    <name>A0AA38NKE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2433 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_81046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793477">
        <property type="protein sequence ID" value="KAJ3782419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="248"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="743" mass="79356" checksum="4732F2B7A02C9E30" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKF3</accession>
    <name>A0AA38NKF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_349475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="133"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="570" mass="61998" checksum="50B2BE0AB4303C63" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKL9</accession>
    <name>A0AA38NKL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_274890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793454">
        <property type="protein sequence ID" value="KAJ3782779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKL9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="890" mass="99169" checksum="6C703978D71E2226" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKQ1</accession>
    <name>A0AA38NKQ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin GroL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_53209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKQ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="598" mass="62447" checksum="30FA2F9B26F38FA6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL72</accession>
    <name>A0AA38NL72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_307057</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL72"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3788402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="280" mass="30570" checksum="A619EF5641330766" modified="2024-01-24" version="1">MTDRHSVFRPCIDLHGGQVKQIVGGTLSDTNPNNLKTNFVSQKSSAEFSRLYRSHNLEGGHVIKLGPGNDEAAKEALAAWPGGLQIGGGITDENAMKWLDAGASKVIVTSFLFPNSKFSLQRLETISSTVGKDRLVVDVSCRRIGAKWFVAMNKWQDLTEMEVCQESLDLLSEYCSEFLVHAADVEGLCQGIDENLVIKLGEWCRIPVTYAGGAQSDGDHIFHSSCSLFPVDISDLGLVNRLSKGRVDLTYGSSLDIFGGSLVKFDELARLSGSLEFLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLM8</accession>
    <name>A0AA38NLM8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_357637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLM8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55560" checksum="BACDCF126D8E66B9" modified="2024-01-24" version="1">MDSSVHPKRILVIGAGVCGLVSLRNLIEYGSFDEVQLVERRDDVGGVWYLDEHGTNNASEKKPRWPSPAYPGLIGNVLPEFLSFSDAPFPEPPTTPEQPFPTLKETYNYLRNFADQYLKQAKIQLNTEVVRVEELQDGTGWNVVTRDWSTAGEGKTLSNVWDGVVVCTGWYDKPLWPKTEGMDIVKEKGLALHAKWYRGPQEYTGKRAFIIGNGNSSNDIASHLAPLAQNPVYRSIRRPSLRHFVSLPDSRIQDVAPVRRFTLQEDDKITAELQDHTIIKDIDIVFIGSGYIPNPSFLYVRNPNSPSFSLAPLMSQISAEAPQPRRIPSLHRHILYAYNPSLAFIGSVMCFTPFTIADVSSMWLTLAWTNEVEYPSTSKDLLQFEKDRIEDIERRREIEAQETGREASSLFTYSALGSSEEDYAAGLKQEIVSSRPELAKVLPEWNDERRIWRQTMYPVKYQSLRWLKVQREKKASIEENVVINSTATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLP1</accession>
    <name>A0AA38NLP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_24256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793372">
        <property type="protein sequence ID" value="KAJ3784549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLP1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="114"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="595" mass="65932" checksum="65DEFE96B53482E9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLP7</accession>
    <name>A0AA38NLP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_357477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793371">
        <property type="protein sequence ID" value="KAJ3784594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="256"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="324" mass="35817" checksum="53D65714F609654C" modified="2024-01-24" version="1">MSSTALKRTWSRTSPGSQGTSGEQETTSYLGVPLPKINGETLLQVLTHRSLRRPDDASENFDNERLSELGARVLDTAITTTLFHRRPVLSGLEMLVQRKRILSEENLDGWVSMYSLREKVRCTREVVSTLKSPEETRILFNSYVGGLYKEQGLEAVQRWLDGLTHDDTAIKPSVTTKVSPTSMQFLSTNSTAGPPPYFNHAPPQKKAKADPSIFIAAQPLPSSSQFFMPPTVFPTQQYTVSGPFANPLSPAQPDLPFLPLFNQTATKRRVAVDYPANCSGPPHAPKWIIQCKVNGILKGTGTGKSKQEAKELAARNAWYNLGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLQ9</accession>
    <name>A0AA38NLQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_247401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLQ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="140" mass="15889" checksum="4680561E727A24F9" modified="2024-01-24" version="1" fragment="single">MVSPWMTNGTITRFLKHNPKANIDKLYTRFQLGIHYLHCQDIVHGDIKGGNILIDEYGQPRLADFGLTIFADSTRHNTTDQGGTLRWMAPELLYPLPGIECYKRTTASDMYAYGCLCVEVYTGQVPFADVRSEIMVLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMC1</accession>
    <name>A0AA38NMC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_178272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMC1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="105" mass="11560" checksum="8013BB78D83566D3" modified="2024-01-24" version="1">MPSIAISTTRHVRFSDELAKPPSDRRRIDGLVYPRVAQIKGEANKHDSFDLHWKLECLSAASRVGTVGSVEVKEDEGIAMNPRISSSLPPARLGPHGWHSHNVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMC4</accession>
    <name>A0AA38NMC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_351672</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MU793313">
        <property type="protein sequence ID" value="KAJ3786483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMC4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="371"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3786483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="574" mass="65900" checksum="2F56AC835B5D575B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNG9</accession>
    <name>A0AA38NNG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L34.e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_346419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNG9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="113" mass="12752" checksum="6B658AAE560E0CB2" modified="2024-01-24" version="1">MAQRVTLRKRQPYNTTSSRRRIVKTPGGKLVYHHLKKPATAPKCGDCGIGLPGIPALRPRQYATISKRQKTVRRAYGGSRCGDCVKSRILRAFLVEEAKIVKKVIKSHEQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNJ3</accession>
    <name>A0AA38NNJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_345213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNJ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="562" mass="61375" checksum="F582FC7A08399281" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP00</accession>
    <name>A0AA38NP00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inhibitor of apoptosis repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_429552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793485">
        <property type="protein sequence ID" value="KAJ3782300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20410" checksum="64B788E8FF1CF486" modified="2024-01-24" version="1">MDIFKARLESLTRPKRRLKGGTKSQSNQKWPHPEYFLATPETLAEAGFYFDPSSEDKDNVTCYMCGKELSEWDERDDPFGIRCKKRGKRYAWANVRRGLGAEMDADGRFVFPDKNRLPTSKAMEKARLDTFLFGDASSKRRSMAKAGFVYSPHVSHNNTTICIYCGISLSDWDADDGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPM2</accession>
    <name>A0AA38NPM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_434417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="275" mass="30876" checksum="BB2972650FAFFA0A" modified="2024-01-24" version="1">MSHELSPSSSRWSPSPSTTSSSDDSLDSSTSAISTSTNSSSSSFTRERRGMTRYAFPEFAPAPSRLKRTLKYAPEHVLIRARNANIPILLRDQKKKTNHAAVGRRGHISDDDSDYEQPHLQNQQRPKKQKVKSHEQLEAEERRMLERKAELADDPLLDASRMCPDKVWCLPCSKYIQIDSRRQFYGTLWYKHRGKRHGDVPLKRSDMDNVVNMDVDMNEASVNCTDKSSASRESESSVAFAVPVIDDAFATNILAEMYSKAKGLRLLSLAAAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPQ6</accession>
    <name>A0AA38NPQ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA splicing factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_420471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPQ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="431" mass="50049" checksum="96E8337C5008B8A9" modified="2024-01-24" version="1">MGGGDLNMKKSWHPLLLKNQERVWLEEKKALEEKKKLDQLRKEKEEERQLQELQRLQEEKTGKKRTEKLEWMYTTPATGSTQNTNDLEDYLLGKKRVDKILTADENAKLGASHKNFIAVQNANNARDIASKIREDPLLAIKQQEQAAYEALMANPLRLREMQMRNGIAPKKDRKERKREKEEKRRLKEEHKKQRKLQHRYSRSPSPPNERYDDSDRYDRRERHRSSTPSRRSSSPHSRNSRRNDSDFDSSSRRRRQSRTPNARHRHDDGPWSRSQSASPLSDNNRGRDSRPHNRSAEFNSRRRALESPRRGKRSRSPSLSRDTRLDSNNNKRPRRSPSPLPALSIRTEDDRAARLAAMTGNAEATKIERQERLKMLLEKEKADLAAEEAARSKSRGMGGFLSQESKKVFGGSGGLEDRIRRGRGGLVIDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPV2</accession>
    <name>A0AA38NPV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_350592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPV2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041418838" evidence="1">
        <location>
            <begin position="16"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="218" mass="23648" checksum="7AEF2C6B9FC09315" modified="2024-01-24" version="1">MLFWSLFGFASVALAAPAASDLQCSPAVNGTLQLVMLDNPSITRTGASLHSPDYVVNDVEAYLLKIFSPTNAEFVFNTCNSSFMGWAQSYSDTGVTFLYGQLQDVGTGLCVTASQLGDYVTTEFYGSDCSVLDDVSQLRQFFRIEIQPTATGETGRDPLPSISFLGVPQSSDPDGAERYSFTYSRDNLATGDSLPNVVASNPRTDDSDLGFYAPQYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQG6</accession>
    <name>A0AA38NQG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_66707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQG6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="200" mass="22001" checksum="A0181EAE1A7B67F1" modified="2024-01-24" version="1">MYLCGLDIRAGLSFKVCAVLFLGLVCAAFTAALPLSDNDQSNPTSSVHLAARNDLKRLPMMLRFVYPKGENSILDCKPLNKDKTVKQVQAYLERMQSGFGFVPTISVEDAMDHPSGYIPTNTVNFELKLKGSPTEESKEFWAKWGSWKEGYVQIASPFSLKKSLIHQGQSVLITLKDNTLEITGKSSIALASATVQPDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQW2</accession>
    <name>A0AA38NQW2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cellular morphogenesis-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_343338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQW2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="893"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="107539" checksum="A06476A93AA2DABC" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQX0</accession>
    <name>A0AA38NQX0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_49112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQX0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="196" mass="20656" checksum="D0BEE040D4D875D3" modified="2024-01-24" version="1">MASIFSRPISPPPRALSPDVANLPGLNPLPLPPARSKRLSERSTPNSSTSRSSPRPFLPNTPSRGILKPTPPPSPGSPVSFISSSSTSSRGSTHTLSHRRSLQFAIPYRSPPASPTLASPPPPVPPIPAFALDSGKSRPHQSTPPPPPPRPTRDPRRDPQDGLARGGMTCTQFMSMQGSRPGSGRLRNPAQAPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR00</accession>
    <name>A0AA38NR00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP11 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_49816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="37791" checksum="7423424642B4FA7E" modified="2024-01-24" version="1">MQRCLLRNFTPRAILPRISPTRRAFHANEDFESKYADKLRLRAQDQGVSISKLKEDAKEQQEEEKRRIREANNQAIRARKEAIETESSVPQPAAASIPRKDGSPIKPLDSILNLSRIVSVNASQISALWTAYHASRSEGTGRGYLCATIPLESYEKMAAVATKYHSFVLPVPRPSPDVSLETPATTETPHEFFFMEWAFHESPSIPSAAEPDPFGPSTHTSQAAHGSVNPPNSTILFTPLQEFKMRNSFATPYLVLTHYTDLARTHGIVLLRGEITPGSGNDGRYLLSQEDAQILSMNVQKFYLWSEKGPESILSTFHEKPSEFDWQEMLKYSTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR75</accession>
    <name>A0AA38NR75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial distribution/morphology family 35/apoptosis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_38558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR75"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="103" mass="11589" checksum="DD48B72A550AC847" modified="2024-01-24" version="1">MAESLLSECTPLKKEYDSCFNAWFEGYLEPAVSASSSPEKYSEYSQRKAEEFQQKCGKIWEGYRACVQKALKEKGLDTMLQQSREENPLSRPPPLPPSGSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRP7</accession>
    <name>A0AA38NRP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_304235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041283997" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="565" mass="61554" checksum="04CC936B42F60146" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRZ9</accession>
    <name>A0AA38NRZ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_10445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRZ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041411342" evidence="2">
        <location>
            <begin position="25"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="879" mass="98897" checksum="2E7592CAE4FD7BD9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS38</accession>
    <name>A0AA38NS38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_3809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS38"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="307" mass="34139" checksum="4D7596F67D92D7F4" modified="2024-01-24" version="1">MFSDLGSPTASFGLNRSFASRTASPKSFHFSSVVGAPTLVLPLEPPSNPERNHKPTNSTSVLPPINTKTTDFESLRGKYYLDHPMPIVSFVVQGRLFKVHRYFLERDSLFLRGALSTVQGIQGQPIQLHGVSSREFESLLDFLYEGMYRSGADTVPVSEWLNVLAAASALKFDRAREHAIAAIDNSSERPDAIEMMILAEKYGITKWLRPAYILMCKRAEPLRLSEAERIGLDKVVKLTQAREAFLRESLGVNGLRAVSPLPSPYPWPPSNQTQGFIARTPTPTLAVEEAARIVDKIFFTSDMNVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS77</accession>
    <name>A0AA38NS77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_392286</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS77"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3790114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="127" mass="14463" checksum="1164AD221133ABE8" modified="2024-01-24" version="1">MLQASLQFCSECNNLLYPKADPHRRIMVFACRICQYEEASESKCVYRNDLLTVTKEQVGVTTDLGSDPTLAHSNVECPRCGNEDAVLFQDQSKRKETRMILFFVCSKCNHSFTDPTVQSDTRENEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS89</accession>
    <name>A0AA38NS89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_258989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="440" mass="51494" checksum="2EF1A08CF09E9531" modified="2024-01-24" version="1">MIFWPIEELGGTVELSRRPPEPPTWARLRQWEDDLPQHDLSLPFPEGRTGRYVKFNNQIRMLGWNNVLNEVLMNAHLSYISGRSYVFLDYYWKPEYYSWPKYQFRTDPPRTPLNALISGPAAGGPWDEGDEAPRAISERWYEVVCPYKERRFINTREFKPAVWNSPGIDMLNHWAQVLRSAPERCIEIQGDDEHDMFPQVFDLWMWGSTRVLSLWEEFSRSPVSRLLQTSPVVKSAVDANEYLFYPRGSRLPLSNLGPRDPYDRMMAIHIRRGDFKEACMRLAYFNSTFYSWNLLPQLPDSFEVPPSMIWNSSEYNQYYVERCFPEQQAIVNKVGEARKAYINAGKHEKRTLDVMYLLTNAKGAWLETMITYLKQDGWHTIVTSKDLELNAEQTDVNMAVDMDIARKAAVFIGNGWSSFTSNIVHRRLVDGKEPLSTRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS93</accession>
    <name>A0AA38NS93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_371438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS93"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="229"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="407"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="916"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="999" mass="110562" checksum="AE4BF374BF064869" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT87</accession>
    <name>A0AA38NT87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphatase 2C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_328919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="310" mass="34363" checksum="A2EACD2A5938BBF9" modified="2024-01-24" version="1">MTQVLNRIPAQCDSYQIGVHEAQGMRPTMEDTHAFIVDFDSVRGQGYFGVFDGHGNKCVSEWCGQEFHKIFLNCIHKNPHLNGLDLLKKSFLEADEVLGKMSEGSDELADSGSTAVVAFLRIEHADGSQNFPQTDLSEHNKLKLPPQDARRVFYCGNVGDARGVMCRNGTATRLTHDHKPSDSDEQARIRGAGGIVLRGRVFGTLAVSRSLGDHMRYESLKLKDLVIGTPYLSRTELKGNDEFCIIACDGLWDVISDQDAVDLVRDIGDAEKASQMLVNYALKNDNMISRDNVTVMVIRFTNTSPSNHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU39</accession>
    <name>A0AA38NU39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_313</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU39"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="364"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="660"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="751"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="707"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3791181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121082" checksum="C56E1084F534E892" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUF5</accession>
    <name>A0AA38NUF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_2243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="443"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3791284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="569" mass="64347" checksum="0D25054C3B2D2448" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TXT4</accession>
    <name>A0AA38TXT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_305668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TXT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="352"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="480"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="861" mass="95537" checksum="43AD4A7588B1B8B4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TXT5</accession>
    <name>A0AA38TXT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_344312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TXT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="444" mass="51883" checksum="6AE4759CBA29C6A4" modified="2024-01-24" version="1">MPGTLRRKHRQELTLRRSFMEAMQAKLSSSLSRRTNEKSSPRPPEIRRRDPYELRYQASSIHRSSATSYSSPHSIRILPPELLAYIFVLGSEDDPILPLSVSHVCSFWRALALSTPKIWRRVVLGSHYSMWRETIYHARACTLDIEFQSGNRRGPFAFYEVQRYMHLVMPHIHRWRSLSIVFTEYQPYLWNSALSECCTRCHDTQAPELEDLCLVYRHNDDTKEFCLFSGYAPKLQRVTVDGIRLTWLPSLFQNLTHLDYTHHGLTNGSHAVQEIVNVMRVCSRLTELRLLFPNRGFRARPPNHPAFPPFASVYFPWLKVLHLRVETKDVPEELILIASIFNTPRLSELRLIDNVGQRTSFEQIRMFWSLYTIPDALRTIHIQNGWYTKDAVLFLANAGSVKWLVIRCGEGDVVHWLDSRGPGRRRPRPLIQSYTGPEFLSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYC4</accession>
    <name>A0AA38TYC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_260564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYC4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="162"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="392" mass="44626" checksum="C28FE7D2768A77FF" modified="2024-01-24" version="1">MGVPVVTGYYRYTDIWFEWHKQLGEDGEVLKAALAHDALVSPEHPLHVDGVDGVQLYIGTLKSGETRLLFSSKQVEYVRYWLHAVGLTKNPIGLPYSDCLLRLQDLRGVSPQTFQTGGELKNSVKKIEKNNKNIKKSSDPPLTFRRSSFETVRRLWQNKIGVWCSVDFEAWERDHTVITEFGWSRIHWEDGRETREEGHLIVQEYQTYTNGTYVAENRKNFKWGQSEIVSKKEFKSCIQNFLSDLRRNDHTFLVFHDAKEDLDYMKSAMVEADLSGLSYTLPDGPSPKSGVFVVDTADLFGGLQGEGTRNRGLEQVCNQLQIKTEFLHNAGNDAHYTLEACKEMASGDSLDLQREKRWPSKTTPGTVTVNIDSLEEEEDASDEEGVFMSALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZQ9</accession>
    <name>A0AA38TZQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_384205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZQ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="49"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="289"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="467" mass="52659" checksum="12382333FFD7542A" modified="2024-01-24" version="1">MPMRIPSLWAEARLAIAHEEEARSSVATNFHTSLEPLTDDLPPRNMHDSYTQFILHFSSDPNLLEEYVNASGGIRTGKLMEHLDSLAGSISYKHVLGPTKSELKVEEMGLYIVTAGVERIDMLRPLTSDRDLRLSGQVIYTGRSSMEVVVRIESVAPRGTQEKDETILLGRFSMVCRNAKTNQAYPVNPLIISTEAEKDLFSIGQELKRRRASLAQRSLSRVPPSSQEAAALHQNYLEFGESISQHNYGHQQTSPSVKTVHYDFIGLGDSQDSLSSAGLDYTAELVPMGETRIERCMLMFPQERNVHQKIFGGYLMRLAYELGFSNASMFCRGRVRFLALDEISFKLPVPIGSILRLNSVVLYDDFIKEREGNGEDNVYQLVHVGVRANVVDIKTGTEKTTNEFRFTWRSEEKLARVPGNHHVEAKKVRKVVPKTYREAMLWLEARRAVAVGDGIRALTTKRQQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0S6</accession>
    <name>A0AA38U0S6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_341905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0S6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="482" mass="52736" checksum="5A9D586BC253B31B" modified="2024-01-24" version="1">MKMPAPSLPTAKVIQVDTRGAVILEEESPETRDSRGIYFPNHIEPVSHIAVDVGGSLAKVVYFTRSPEPPSSPSVAAIRSSSPPEPSTPRSNSPSAEFPTSGSSPSSSNIRYNGALTPLVLDSQNHVDGFTLNSEMLRSTMLRRTSQHFPGGSLNFERFETDNIHQCVEFIQSLIERSAKVNEVTIEDMRKSVKIMATGGGAHKFYELFKDTLCVEVRREDEMECLIEGLKFITLIPDEAYYFSDELIQSVSHPTLSPSDQLGLLPDGVLERPGPNPPKFAVTFESNPSPQLPCLLVNIGSGVSLIKVDEDGRFERVSGTSLGGGTLWGLLSLLTPATTFDEMLNLSEQGDNATVDMLVGDIYGQDYSKLGLKSTMIASSFGKVFKKGKGKRTFSPEDISKSLLYAVSNNIGQIAYMNAEKYNLERIYFGGCFIRGHAATITTLSYAIRFWSKGTKRALFLRHEGFLGSIGAWIKNIGPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1D9</accession>
    <name>A0AA38U1D9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_179267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1D9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05500">
        <property type="entry name" value="Bromo_BDF1_2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="252"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="469"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="641"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="719"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="792" mass="86888" checksum="DB2273B78FB8CF5B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U648</accession>
    <name>A0AA38U648_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_342512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U648"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="769" mass="86255" checksum="6751FD58656011FB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U678</accession>
    <name>A0AA38U678_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_18253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U678"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40549" checksum="A467A7B06B58761B" modified="2024-01-24" version="1">MIDHLTGESQSNLKAAIARTVTRGIALYFSRPVRLFRPSKVSGWHSLRGLASQEGSPLTPGFVKSLVKDQGLMVLPRHFVPPMLVNTLLGTVLWTTYTEASKVIEPHLPRHPTMTAALSGAIAGGFQAIVAAPAENVRLLFEGGFGYHSWSHAWKDVFRGTELRGTTSRMENIEDARQVRRWMKEVGDMAGRGWNGWYWGCAKDMTGFAVFFSIFEVTHRIALHTRERTTIFVRKTSSSDEFIMRHTPRTIYGLTLVSGGVLAGLAYELTGRPWDHARRIVHMQKLQKPNERIPWSAILHQFRLDGLPVFFQNPALATAKSSDPSVYRGYRPKMAVALRTLGRVGPWGIGFLIYASFGPDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8E3</accession>
    <name>A0AA38K8E3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_336046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793521">
        <property type="protein sequence ID" value="KAJ3781824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8E3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="177" mass="19304" checksum="AE0415E3C31E3E2D" modified="2024-01-24" version="1">MPTNTPLGLKNDAKYAFESFRNCDDVFPNATYVVSSSPDGFAFVLGFLAPLWVVGGFDSSVHISEEARNASTAIPWAVMLSTAASCILGWGINVSLTFNMGKDINGIFSNAIGQPLATFSSTRHFSALEYIDHGSVHGGHKPPGVIFQADFCIQSRWRIGFFKVNNVEEFESLEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K971</accession>
    <name>A0AA38K971_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_360188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793408">
        <property type="protein sequence ID" value="KAJ3783699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K971"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="28"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="384" mass="44414" checksum="53E5FA5A57E194CA" modified="2024-01-24" version="1">MSSTVPPTFNDVGIANLPNQRHKIVAKHGAHFTIMVVGESGLGKTTLINTLFSTELSPAKNYSRRHHKQLDKLTEVEIIKAELEEKQFKVKLTVIDTPGFGDYVNNRDSWSPIVEFIDDQHEAYMRQEQQPQRSEKTDLRVHACLYFIRPTGHTLKPLDIEIMKRLGTRVNLIPVVAKADTLTQNDLFLFKQRIRDVIQAQGIRIYTPPIEADDEGSDHARILTEAIPFSIIGSTEDVQTADGRVVKGREYLWGVAEVENESHCDFKKLRSLLIRTHMLDLISTTEESHYENYRQQQMETRKFGEPKVKKLDNPKFKEEEEALRKRFTEQVKSEEARFRQWEQHLIAERDRLNKDLEMAHSAIKQLEAELDNLQVGYNRGSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9D1</accession>
    <name>A0AA38K9D1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_39657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793394">
        <property type="protein sequence ID" value="KAJ3784014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9D1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="3">
        <location>
            <begin position="72"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="38466" checksum="E300F988D3BBF078" modified="2024-01-24" version="1">MLLKAFALLPDDLVTELASLGILTSTDLMFSSTTPLEIYSRLSSKSISFPEFEACIKVILTKLATSGQEAVELDQLSHSCFKMETLTSLDNYLDGGLPCARVIEISGDNDSGKRILLLNCVLMSLLRNREIEGLWIDTTGDFLIERAVTILEHHQQSLDDMEILLQRLHISIATDMESVQQIIRALDFQLALQASSIQMKYIVIDSVTSLFGPYLSAVSSQGHAIMAAFMRYLRDFAKRYSVIILLINNATLMQPPSTARAQTTAEVTNPRSVFASTIRKPALGPSFTFMTDATLWVSLWPAQEEDEEKFTTHVVEVFRSKFSVSNVWSAFRIAASGALLTDCTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9L2</accession>
    <name>A0AA38K9L2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_357784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9L2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="108"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="34364" checksum="D20FBB45E7FAFCE0" modified="2024-01-24" version="1">MPTTIKSVFNLETSTNTPVGLDTTNYHEALVANCLDGLPPFEESSYNPSGEPAIKYIQPPNPGWKFGESVESTELGRKWMEGAKFEDDWEHFDAEKEENRKIYTLMISGIQPRPIAFVSSVSATGEENIAPFSFFQALSPSPPLIMISALNAPRVKDTTANIQATKEFTVNIISLPWIVQANAASIDAPVHISEWEVAGLTKEPSTHVRAPRVKESAFSIECTLFDKYDVVHPDTGVNTSTITFGLIKCIHVRKDVLNARGLPDPAKLQSVSRLGDISYGLTTEAFRLPRPSWASDGETIEKILEERKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAA3</accession>
    <name>A0AA38KAA3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_387235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAA3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="360" mass="38499" checksum="C68334E89DDBB50D" modified="2024-01-24" version="1">MVISTSGLSEDIWVNFDYALYTFQDAAVISSSESSSTTSSPNNPPSASASASSNMGAALSNSASSMHLGIVIGGVVGGLAVLGILLTVLFICHRRRGKQHQLERLNSHAKDDPESGIKDPDNLQSADVDSRILPKTTASTYGLMPGHQHHDAFRSSLTVHGTETPIGTTPTASPIDGVDHSCGPHTEVDGIYSPEYQYRSVISTLPSGRIVMAPGTTQDSLIPPLPSSTNSESTSATTTVPKANTTPEKSELRRIRQQELDRQMGEINEEIEELKNEAAERSDPSSLGLASRSSIRKKSVRKGKDKDQKMESVAQLKAQIRQMSEQIALLQAQQNSAWAQGLSDEPPPGYSPRPLVVNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAB7</accession>
    <name>A0AA38KAB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_427751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="271"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="371"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="465" mass="49606" checksum="573367700FCCC20E" modified="2024-01-24" version="1" fragment="single">MGKSEKKVSKVDKATTKAATKDTAKKAENPPKTSKTKTLKQTPVSSKDILAKAKKAQDASKKAKSDSEEEEKTKPKVNGKAKAPPSSDESSEESSDEDEKPKAAQVKKAIAAAKKSASSEEESSDSDSDSEDEVKKPSATSKTAKTTPSSNKQKDESSSDSDSSSSEDEAPKKDATSEGTSDDSSSSEDEVEKKKLSTAASTVKTKDSSDNSSDDDSSKNDDSSDSEDSDAEMEDGTKTNGKRKATEDAPAPPKKMKLANGEAMPAEEETQSIFVGKLSWNVDNDWLAQEFGACGTVVSATVQMDRNTGRSRGFGYVHFSSSDAVAKALEMDGKEIDGRPIKVDKSTPPNKDNVREKRAKTFGDQTSPPSQTLFVGNLSFSANEDSVWEFFNDYGVKNVRLPTDRDTGRPKGFGYVEFDDIDGAKKAFEAMNGQDLDGRTVRLDFSQPRDSAGGGGGRGGRGGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB24</accession>
    <name>A0AA38KB24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794756">
        <property type="protein sequence ID" value="KAJ3779503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="118" mass="12774" checksum="378FBD0827267BAF" modified="2024-01-24" version="1">MSTTSSPTRPARSPTPVLNDEDADLQAFLAAAKREAQEKWEKLRAAKTSGVEEKAGEDGGGPVEAKGNAEEEVVEVEEEIVPKIEARPRKVVTRMVAGLPHNREVIPVSLLLSIPEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC51</accession>
    <name>A0AA38KC51_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_89357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC51"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="205" mass="23863" checksum="FD0D607667D50765" modified="2024-01-24" version="1">MSIPLEPLPQSPSQSKSKPKPNHSLSTHLIFLTGLTTTCFLPLTLLPYLFARRRLGSLQNRVRELEGLYREMRGGWREGEKERRRVGGLMSELEEEVREGRRRFEMKMKMEMEMREKEMKTREKEREDECREIQSDIRYLLDQAKITRTQGLAVKSIGLSLADIASFIHQVELSMPTATATATDNKNRVDRLWVTALMLQNLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCJ9</accession>
    <name>A0AA38KCJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_365309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793516">
        <property type="protein sequence ID" value="KAJ3781888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCJ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3781888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="559" mass="61567" checksum="91C676D75C3C4D94" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD19</accession>
    <name>A0AA38KD19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_419232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793926">
        <property type="protein sequence ID" value="KAJ3780086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21156" checksum="20DDCA6D9D090D59" modified="2024-01-24" version="1" fragment="single">MLSQRLTRVALVTGAAQGIGKAIALRLASDGLKIALNDIQSKGDQLESIAEEIKKSFGSEVYAFPGDVSEERDVEYMVEAVSKGLGSLDVMVANAGISGPLTPILATSKYLCNCEQWDDILRVNSKGVFLCYKYAAKQMVAQGRSGGRIIGASSVTGKQGMAHTSAYTASKFAVRGLTQVAALEFGQYGITVNAYAPGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDH8</accession>
    <name>A0AA38KDH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_278604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793638">
        <property type="protein sequence ID" value="KAJ3780866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDH8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="168"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="352" mass="38927" checksum="76AF327BCB8C0AE7" modified="2024-01-24" version="1">MPVAAYPEFPTNIPTHPLLVVDYDLIKNGNEKEIDVLWRAATTLGFWYLKNHGAEEDVEKMFDMGAETMDLPLEEKMKYEQGDGGSSFGYKFSGANAVDASGEPDKIEFINIAKDDALAWPKQARRSYPSTVDNRMESTIIPFVKKSIEINDTILSIFNSKLGLPEGTLKSIHSMEEYSGSEARTIKAPKNLPVGRQALGAHTDFGSLSFLQNRLGGLQVLPPGVDEWQYVKPLPGHAICNVGDALALFSGGILHSNIHRVYPPPGAQAGFERWSQVFFTRPGNSVMLRPLSDQSPAIAEAVSRLTEEQRAALNPGVTALDWFNRRIKNQRVKNRTGPETWVASRGTEQGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDW8</accession>
    <name>A0AA38KDW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_390466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793536">
        <property type="protein sequence ID" value="KAJ3781646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="547"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="485"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="675" mass="71676" checksum="57A6A34AD98A9366" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEB7</accession>
    <name>A0AA38KEB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_79789</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793473">
        <property type="protein sequence ID" value="KAJ3782486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3782486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11554" checksum="0C6D76D0DEB6AC3E" modified="2024-01-24" version="1">MTFNPDRFLRNDLAVVDPVSVAFGYGRRICPGRFMAESQLWISIACILSAFEIRPENDERGKPIVPKAAFSSGFICHPLPYKTSINARSTGSKFLIEQTTDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEP7</accession>
    <name>A0AA38KEP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_389389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793439">
        <property type="protein sequence ID" value="KAJ3783056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="763" mass="81962" checksum="6BFCA106E4464C1F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFC1</accession>
    <name>A0AA38KFC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_374950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFC1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015417">
        <property type="entry name" value="T31B5_30_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="1">
        <location>
            <begin position="62"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="2">
        <location>
            <begin position="491"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="726" mass="82066" checksum="DD93507831E0E2C0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFK0</accession>
    <name>A0AA38KFK0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_310329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFK0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17769">
        <property type="entry name" value="NP_TgUP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF14">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="358" mass="39092" checksum="950061FBB739AA20" modified="2024-01-24" version="1">MKDKLTDANFPRTADNRVYHLGLRPGEIANRIVTVGSPSRALTIATHFDEEPKKFRLVSERGFQTITGRYKGVPVSVISIGMGAPNMDFFVREARESIAGDMVIVRLGSCGSLNYTSAPVGTVVVPKACVSITRNVDFDFGSSNDEHIEEKAYRISRPVSDDPQLHQLIVSSLENARALGDQGKIVGDLVNASADSFYSSQGRLTSFPDHNAHLVEELLQQIDNLGTLEMETHHLYHLAKCWNNRPNQAFTNPNSDHTGPPLTTGPVRPVTLTSSPSGVTSDNAPIPATIMDSKIHVSAAQIVFAARTSADRDFITPERVQAIEEWGGKGVLEALIAYHVPSERLHPEKGSAWSMQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFQ2</accession>
    <name>A0AA38KFQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_28042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793375">
        <property type="protein sequence ID" value="KAJ3784466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFQ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="308" mass="31669" checksum="A4E09E6B5C7CD624" modified="2024-01-24" version="1">MESQVPDESLANLTTSNETTGEGELRDNGMATGARFMRGNKGRGSDVNLTRGRGGNGRRGGRLGRGGVQGGAQEQGRGARGTGRARGRGIVNRNVTNEDGGASGNHSSGDDSDDGAVRNGRGRASVAVRRGEGRIRGGLRSRGRGIASQNTQVGESGDGEDGTVGTGGERARGAGSREGRVTGRGRGERNSERSGGGGSGRGGVRGRGVGQSGGRGNGERGGRGNRERGGRGNRESGSRGGGNRRGIRRGRGQGLSGTGYHAGEPFRPGVFGVSLTGRTIYDWEVSGEFADYYNPELGFSPSDYDRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGI4</accession>
    <name>A0AA38KGI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_385058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGI4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="934" mass="103266" checksum="290087D77C5954AB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGU7</accession>
    <name>A0AA38KGU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_384622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGU7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="291"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="392" mass="42567" checksum="83E05EE52D2BA9BD" modified="2024-01-24" version="1">MTTVQKIKEIEDEMAKTQKNKATSYHLGQLKAKLAKLRRELIAPSSGSGGGGGGVGFDVARTGVASVGFVGFPSVGKSTLMSKLTGTHSEVSEIDFTTLTTVPGTLKVHGAPIQILDLPGIIEGANDGRGRGRQVIAVARTCNLIFIVLDVLKPLGDKKIIETELEGFGIRLNKRPPAIIVRKKERGGIAITNTVPLTKIDHDEIKAILSEYKINNADVAIREPNATADDLVDVIEGNRVYIPALYVLNKIDAISIEEIDLLYKIPNSVPVSSKEWLNIDELIDSMWKALDLVRIYTKPRGLPPDYSAPVVLRHGKCTVGDFCNAIHKEIAKQMKYAIVWGSSAKHSRGQKVGLDHVLEDEDGDGSHLEIKASLTIFQDYSSVRACASFSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGU8</accession>
    <name>A0AA38KGU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_351984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="330" mass="35769" checksum="37B6BE27CBAB374F" modified="2024-01-24" version="1">MNPRIGSALTFSQMMFITLQSLPGFITFDSSSTRIEEGNRKTYLPRLKPRQVPIMRWFSQVLVHTTGSLLNNWAFAFNVPLTVLIVFRSAGLAVSMVLGYFVLGRRYSAIQVTSVLVVSSGAVLATLSKTSTASSTVDLVDMQRYGLGIVMIVTSLLLTGILGLLQEQTYKEYGPFWKEGVFYTHLLSLPVFLFLARDVKQGLASLNYPGSSVSGPAPGSAFSSWLILSGNLVSQLLCVSGVNKLTSRVSSVSTNLVLTTRKAISLCLSVWWFGSGWNAELAIGACMVFAGSLAFSLASSGTSVSSSEDDRESARDVHSSKRRKGKSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KK55</accession>
    <name>A0AA38KK55_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_400669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794473">
        <property type="protein sequence ID" value="KAJ3779639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KK55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="159"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3779639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="250" mass="27064" checksum="A38C6F2EDC433C97" modified="2024-01-24" version="1">MGPSSGGNANANLLSAVYMNVSELLPMSSQRHKHQVSLATLNPILFRDHTTASLGKKFFLLFPGLGYAAGYKVAQHVYKFLTGIGEVVLLPLDALKIKRQVNPDAFRGRGIIRIIAEEKSALYRGWGWTMARNAPGNFALFGASAVTKDYVLGVTDYSKATWTQNFIASIAGAVTPITVAAPLDTVKTRIQNANFESKVNGAVVIKDLIKNEGITAFFKGLTPKIIVVGPKLVFSYTLAQSLIPLFGQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKC9</accession>
    <name>A0AA38KKC9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_370013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793951">
        <property type="protein sequence ID" value="KAJ3780059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKC9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="77" mass="9147" checksum="54F15A7612DC6E22" modified="2024-01-24" version="1">MICSKSRLIIRVFLLIAGIPATTYYLFWARRQSEGTTIRYYRARILHREGSSVSPHQRNFSWYSKIALVMVNDILFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLC3</accession>
    <name>A0AA38KLC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Quinoprotein amine dehydrogenase beta chain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_379529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793558">
        <property type="protein sequence ID" value="KAJ3781439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLC3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041302788" description="Quinoprotein amine dehydrogenase beta chain-like protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="35801" checksum="3AFE63A6F939575B" modified="2024-01-24" version="1">MHASFGLIALLSSAAGALCATVPYKRSLTLNAATLVTPKVVHTFPNGTNMENLAVRASGQILCTIITGPDLFQVDPIVDSPATLIHSFTGYETLFGIAEVQPDQFYVLAGNASAATLTSVPGSWSAFHVDMTSFDSEGTATIDKVADFPDALLLNGMGLLNQAEGLVYVADPFAGAISILNVNTGDHYVAINNSLTVPAAPFTTPLGVNGVHVFQQPDGPLYVYFSNTAQSLLARMPINATGVPTGDAEVVASGIIADDFTFDSAGNVLQAVIGSDEIVKINPATGTITVLAGSPNNTELRSVSAAQFGRLSNDSTTLFVTLNGGNLGAGGPVVPGAVKMLELGTTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLP1</accession>
    <name>A0AA38KLP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_298807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793513">
        <property type="protein sequence ID" value="KAJ3781919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLP1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="201" mass="22436" checksum="5D7855DAC4B3492F" modified="2024-01-24" version="1">MSKTAEAATEAIQSEVDHLADKNVDSTDTELRYMAYGARLRTALRASTRYIAYTSDIGEAFRPVVTPWMVTAAYGISWLYLTGDVGYETYKAHRHGPSSFEAANFSEPTRLAFTAVQRATFQSIASMALPALTIHTAVNQAKKAFKNVKNPRLKLWGPTATGLSLVPGLPYLFDHPVEQITDKVFEWMKERVAENKKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLU5</accession>
    <name>A0AA38KLU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_390072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793497">
        <property type="protein sequence ID" value="KAJ3782129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLU5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041224273" evidence="2">
        <location>
            <begin position="19"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="296" mass="31853" checksum="ADDA447DE7D63A26" modified="2024-01-24" version="1">MYLSLACLILCFISSAFAIPLTVVSDVGFQTRSEPQPPGLIQVTFPHKANSKLQNAASVCDHIKQALRYATSVLPELQGLGVSCGDQYHPSKRPIPFTFTVPVSKHVKFCDPVCTGMILPTGSILISGRETIYEGNKLTQMVTIGDSSSDLGAPSSTDSSENVPAPKSGTHIKVDVAYTGTGEMTHKEMQEKVEKLFNYVPHGLAGMNMPLTFTYGKNINPGPLASSGSGLGAAGLPRTIYFKFISSPAIDFCRPDCNGRLWVDDGAAFILGPRAIQRTTSGELKIQRLIKFSPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM00</accession>
    <name>A0AA38KM00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">GGU10DRAFT_275685</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="MU793480">
        <property type="protein sequence ID" value="KAJ3782369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5041497433" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041497434" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1235"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="478"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="217"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="799"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="865"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="874"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1090"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1235"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1235"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1234"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3782369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1279" mass="140953" checksum="A623100E1895826B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMA1</accession>
    <name>A0AA38KMA1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_390190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="MU793508">
        <property type="protein sequence ID" value="KAJ3781995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMA1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="94"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="203" mass="22440" checksum="5DBB2A9F4D4C0F9C" modified="2024-01-24" version="1">MSHTLPPLPYEYDALEPYISVEIMKLHHTKHHQTYVNSLNLAEAAYAKASTPKERIALQAALKFNGGGHINHSLFWQNMAASSEKGGIGGVLKDGPLKEAIIASFGSLDNLQKEFNTTTAGIQGSGWGWLGVNPSTKRLEIVTTANQDPLLTHAPVIGVDIWEHAFYLQYKNVKADYLNAIWHVINFEEAQKRFVEATTGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMK8</accession>
    <name>A0AA38KMK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_377881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793431">
        <property type="protein sequence ID" value="KAJ3783209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMK8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="205" mass="23580" checksum="95E8C49C16C91ED1" modified="2024-01-24" version="1">MSSVENEAKRVNQAKPENELGSSKDENEVKVETENGSKDEDPYKLARMHAFQLSVLSRNYPPVNNDLPTGTKDLPAKFQVVPKTLQPNAPKVHYGFGLYFIDCVDYHKAHHLESRLPPPTVDEGTYMWGICLTVIQHIAGCCDFGFIDIQRAKTLEFDLILSLYDNHTIWSRELVEAEEEDVISIMRKEMPVLINRELRWFYPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN93</accession>
    <name>A0AA38KN93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_295170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN93"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.15.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="250" mass="28730" checksum="B08ECC5AC16F8219" modified="2024-01-24" version="1">MAPSTTVPSASTIEVPETLLKKRKQTEKAREERLAAAAAARKANKTKRKVIFKRAESYVKEYLTKEKEEIRLKRAARSAGDFYVPAQPKVYFVVRIRGINEIAPKPRKILQLLRLLQINNGVFVKVTKATQQMLRLVEPYITYGEPNLKSVRELIYKRGYGKVNKQRIPLSNNAVIEETLGQYNILSIEDLVHEIVTVGPNFKQASNFLWPFKLSNPNGGWRTRKFKHFVQGGDFGDRETNMNKLIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPA6</accession>
    <name>A0AA38KPA6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 90-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_437164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793535">
        <property type="protein sequence ID" value="KAJ3781656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPA6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="337"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="648" mass="74944" checksum="70EC347F26A83D93" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPB8</accession>
    <name>A0AA38KPB8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_387777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPB8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119425" checksum="BDA4F8EDB9DD8E95" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQF7</accession>
    <name>A0AA38KQF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_387386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793339">
        <property type="protein sequence ID" value="KAJ3785520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQF7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54987" checksum="B92E8934D2D74789" modified="2024-01-24" version="1">MHAPAAPVEDRDDSEVKDVVSQLRQDFSKYVKGVMEGKTPSVAARSTNYNEIQGSDIPLLDGRFNGRAGGQTVAPPIEIYHPVFGAFSERCKDPKLEIPNDVLCDTASLLRSVSKISVQEAPRDSETRGILAKILGVSFEHVVNTDETSCEFMCVQHTPQSINAAPALFQIKGELGAGGSDPSVQASFSYARFYCNLKRAEIRERSCCPAFLIGLAGPWLVIMGAVLTSRVITQRLSPYEWLGCSRVLDDAQVLQVARRLYALRLSIADLKEYYQNLSSPDVEPDHIHPRFCPCIKSFSLDGENVLFVYVQPLERDPSSVTFKAIRSDTQSPIVIKFARRYGEAAHKWMADKRLAPKLLTCESLGEKYGNLLLVVMEFVKGQTLHDAYDPTEPLPEYVRSGVRKALDVLAQGDFVFGDLRRPNVMLENENEGEELEVPLKKRIRFIDFDWAGREGSDLRYPFHLASVVRKASGALENDPITRAHQDKMFENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQQ2</accession>
    <name>A0AA38KQQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_186425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQQ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="200" mass="23312" checksum="D9167C9FE65367F0" modified="2024-01-24" version="1">MLPFSNLFCEPLPPSIDELLTNREQILQRYPRRNFSRWRISRASLSFFSSRDNASASFYRLYEFVVLGWTIQLRNELEYFCTSHPGWAVSDLPDPADTKDPARYAFLAGLTYLMCEAFNRRIELGLPRDAPAIVTDWEELKRRPQVLERVPDWVKSVSPLAEAVRIPDEKGNFVDTNDPEVCTPLSRFNIIMPYPHIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQR0</accession>
    <name>A0AA38KQR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_435885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793415">
        <property type="protein sequence ID" value="KAJ3783516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39600" checksum="E5958693B8DC7128" modified="2024-01-24" version="1">MGQYWKLINVDNQETTGYIGNLGEIFWYQNSVITTLLIAPVIPPQFKSKPAVSKARILEVQNDSTTVPSATLLTLPFEILHCIAEELMDDYLALICFSLTCVTMWELTHPVRYRVLESELKNKSWAGGRIILLGDYARGLPKGMLTAEEIEQLILNHGDEELSDEYSDEDEHVPDNKMDYRLGRLLEDASENFQQVSLKLNISILDDKRVWNHRSLYRQLLNFPPRFRHWFSFEWRQFIPNEAEGGSWMVRNFSKREFVAKFSPRNLTQVVFSLIGRSDDPSISMFEGDWLIDGAWAGDSIDITLASIHEQEHGNETDWKDITAEVKQKLEALAETESQNFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQU4</accession>
    <name>A0AA38KQU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_417713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQU4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57370" checksum="642C53441144771B" modified="2024-01-24" version="1">MHQALLIDEILEVILDSCTESWTLSRIARTCQAWKDPALDRLWWRISSFKPLLDLIPGLLCVNGVYVLELPFCPDFRRLHCYASRVKQIVYRENIRLHPTLLSLLLQEYGQTCIFRKLSIVQLSLTKCSSLSPIISLAKGLKTVELDLGFKTNTFETANRTAFDFLTTADRVSSCFDSLSLRGGASGQVMDSVNNLSRLKVLHLCVGATLPVETLTAISTFPYLRELEIHTSHIQPEDFILSSQGCFPSLHSLNIRGRANSIEKLLQNMRSGNLVALRIDIEPLVYTNNTWGGLFAAIKEKTYDSLLQLTIEHHMDTQDFSLENDTPSSPDTTLHPYVNNLLRTNPNDFLHFEHLHSLSHHRNLRQIVIETTPPILVRDSDLEQIVRWWPNLEHLDLGSVPTFDPRWMPKATLAGLSILSRGLSVLDTLTIPINSAKLTCDAAMKFAGNGNGSLRYMTLTASTPPDKSMAHYLHRLFPSIIEIHGTSGHEEHWDRVQKDFELLKLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQV0</accession>
    <name>A0AA38KQV0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_289123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3787004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQV0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="426"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="787" mass="90349" checksum="7F09F4A2E3B1CE49" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRX2</accession>
    <name>A0AA38KRX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_393435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRX2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="72"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="470" mass="54649" checksum="5BB0934AB2E54935" modified="2024-01-24" version="1">MSLLKVSGTKLVDEKGEEIILRGAGLGGWMNMENFISGYPGCEFQIRAALAETIGAEKSEFFFDKFLEYFFQESDAKFFSNLGLNCIRLPFNYHHFEDDMNPRVLKKSGFKHLDRVIDLCAQYNIYTILDLHTAPGGQNTDWHSDHGVWNHKDFQDRTIWLWEELAAHYKGNKWIAGYNPLNEPTDPYHTRVIGFYDRVYNAIRAVDSEHAIFFDGNTFASDFSHFGDSHEKWENTAYSIHDYSTFGFPAAPEDYVGTESQQRRLRRSYEKKREWMDERGLCVWNGEWGPVYARKQYEGEATEKINEVRYHVLKDQLAIYNKDRLSWSIWLYKDIGFQGMVYVSTKSAYMTKFAGFLAKKHRLAVDAWGADVSAVQHVYQPLINHVLEEIPEKFRDLYPAPVWKLSDRVGRLARNILVAEFLVKEWASHFVGMDESQLDDLAKSFVFEECEKREGLNKILTDNATLVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS13</accession>
    <name>A0AA38KS13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_313419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793350">
        <property type="protein sequence ID" value="KAJ3785181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS13"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="183"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="46084" checksum="4BF143D7C309981D" modified="2024-01-24" version="1">MSVTDSVSVFAEGTFEEQVQELVNYLVRTQSDEERAASIRPFQEALTTAEGQKSLSEDEERRKKIFSMIISAIKGLGRGQEKEIEGFFNLIYAHLFSLFSPSSPEAKQLTDTLLKVISSAPSDQTSIKYRILSNLFNALPRNSSLRLSVYNTILDIAVADNSINALHLSRSNVETWLEEWEVSSEDKSAFLQHIVDAYAKSSQPIKSYDYSILYVRSLPPTSEAAKDASIRVIASALRIPSIFEFDALFKLDAVVANKDHELFALLQVFLNDGLSEFKAWETSHPGALGQHDLDRAQLERKIRLLTLASLGFENIGTNLSYTKIAEAIQVDVSEVEKWVIDVIRAGLLSGKLSQNTQTLHIIRSTARSFEREQWQALEQRLLAWKSGLSSVLDVVASAKRQGGHVTQTVTAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSL6</accession>
    <name>A0AA38KSL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794690">
        <property type="protein sequence ID" value="KAJ3779532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36766" checksum="1D2D856AA363A8BF" modified="2024-01-24" version="1" fragment="single">MPEAKKLSKASLRQLLNEIRGNLPILRNVLMAENKASLWYICFMLNLRTGLRNKQQLVEQILQWRSRSTPEAVPEVPFLSYDQVPDGWETAKNSVELSDSEASETSLSSSVTNSDILPLVSRRAPLFNFNKDADFEDLKSKLLNLSFKAPSLTRPAKEVLQALCQDLNIAYNAQDTKKHLITRLMIYRQENGADDDSNGSEVRYNKLKRQFEEKHRHSTLKQKSIRDVIGKDILEQIWADMERTVLPSWIQQAPPKWGIPASGKLSADEYKVICSIHMVITLIRVWGYENEEGPQSRSFQMLLNFLDLVHSIHVLFLRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSU9</accession>
    <name>A0AA38KSU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_311541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSU9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="3">
        <location>
            <begin position="93"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="199" mass="23160" checksum="607A0442CD2F8E78" modified="2024-01-24" version="1">MQRLRPLQTNPEFSILHTDSFHEYRVENWHLARDGSGTVVRHASTWSWKYSLFPLMLSVSWPKVFAGSLARVLLSLAAIFFVWTRCTQVIHETIIVLPEHGIQLETHKGLPPLTFFTNKRFVPYTILRDLVINEGIKRWDVRYYLVVLKEGTTGRVALEVCFPNILPHFPILLQIYQDLREFVSRQVPSTQSLPHTQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTF8</accession>
    <name>A0AA38KTF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793718">
        <property type="protein sequence ID" value="KAJ3780507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTF8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="15830" checksum="5A780E0F85A24C6A" modified="2024-01-24" version="1" fragment="single">MLRDRFYPTSQSLEDPQRAHRTHGNPVLVEALKKLSLEGRLKFNRDIEVKNEARRLKSIDHAMGNASRPGSPTTSFVTVDSEEIDLIRKEPAFLKRVFNYLGPWALNFIQDRNSSDKRKAEENAETRDIAAKKARLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU61</accession>
    <name>A0AA38KU61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_426489</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU61"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3788091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="174" mass="18382" checksum="CA0185173CFFA13C" modified="2024-01-24" version="1">MPPPKSKGGKMLSLINWRLKVTINDGRALTGQMLAFDKHMNLVLAECEEFRRVRPKKKAGDESAPAEQELKRTLGLVILRGETVVSLSVEGPPPVVDDDKKNALPVGPGRGMPAGRGMGMMPPMGAPSMAPPMPFPPGMPGPPPGFRPPGFPPGMPFAPPPGFAGPPPGFQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUE6</accession>
    <name>A0AA38KUE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_384921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="168" mass="18246" checksum="5ADB87C38918AA66" modified="2024-01-24" version="1">MASIDAGPNVFFDVAINGQPAGRIVFKLYDDIVPKTARNFRELATGQHGFGYAGSSFHRVIPQFMLQGGDFTRHDGTGGKSIYGPKFNDENFIIKHTRPGLVSMANGAPNTNNSQFFITTVVTQWLDGKHVVFGEVVKGMDLVKMIESLGSQSGTPKYKVTITDSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVZ2</accession>
    <name>A0AA38KVZ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794768">
        <property type="protein sequence ID" value="KAJ3779498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="327" mass="36420" checksum="90CF75D883A3C206" modified="2024-01-24" version="1" fragment="single">VSDVDADLRSEDLASAKLTLTLGILPSGAAVLLLTYLQADQVCTFHHIKPPTLYDSVHSSRFESLSPILFVGIETLAQKLHSLSPKSGIRDRDTSQNNRAFALLPQGGRRGLFENLRMLRQVATRRVACPPIALPITPSSPIHAPFAQYSLCRNIHVKLPKLHVATFAYTIGFDMRPKGKGPAVLEIGWAKSRSGMRDLQTSTDCGKCEEIVFGWNKYHTHKLTKNGLHKSVLEQDNDVVCNAIVEKLFQLPAYKEQDHLILVVYDEPQVCATFLDLGVNLSSGCFDSSSGTRYRWRWLNESNGGLKHFLRDVRFLQQQPTPSEPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW93</accession>
    <name>A0AA38KW93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_375638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW93"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041340511" description="Glutathione hydrolase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="424"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="475"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="595" mass="64286" checksum="4501DC5E92059920" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWE7</accession>
    <name>A0AA38KWE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine-S-conjugate beta-lyase</fullName>
            <ecNumber evidence="2">4.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_417430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="2"/>
    <dbReference type="EMBL" id="MU793812">
        <property type="protein sequence ID" value="KAJ3780278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWE7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="699" mass="77561" checksum="AEB501FC40A6A9BA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX24</accession>
    <name>A0AA38KX24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_350273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="224" mass="25378" checksum="6E0BA3A0EB9CDF22" modified="2024-01-24" version="1">MSQPSTPTSPSAPQAEIIQLCSRHFTAIPLSLSRFQRQWFLTFPRTYRLPDPDSQRIVCALNSPDYSASNEHARTHFWLNPSCRSQRYNPSDNTTKYSAVSPIHLLLDSDHPVARLTGRIRSEPSNDPHDEGKRIACYEVEVMTPDDGLLRQCYYCLSWEASGKANTRFCPGGNDVYWCSSCEAAGWVFSTIRKLRLQNILPWSNTDGNSKDNLYSPTRLLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZD0</accession>
    <name>A0AA38KZD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_355281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZD0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041434739" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10057" checksum="B7C879C479CDCEA3" modified="2024-01-24" version="1">MHGPCGEILGFCLVGFCEGLSGACFDFASLRHSCTESCGLCCSNTSCCSCGCSFENDLENTDDLRDSGAHERRPLLEDSNQITAQPEARPVMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZX3</accession>
    <name>A0AA38KZX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_351421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="326" mass="37558" checksum="46FFE6E774FA693B" modified="2024-01-24" version="1">MQSDEVIWSVINHQFCSYKVKTATQNFCRNEYNVTGLCNRQSCPLANSRYATIREQEGVLYLYVKTIERAHSPARMWEKIKLSNNYSKALEQIDSELIHWPNFMIHKCKQRVTKITQYLIKMRRLQSRQEPKLVGVKKKLDRRETVRERKALSAAHLEKSIEKELIERLKSKAYGDAPLNVNESVWQAFLDREKGDKGKGVANELDDMLDDETDEEFEEENEGEMDDWGSREFVSDVSGDEDDDDGLSDLEDVVDEGSGSTDEDGENGENGGSNDENDRPSKLGKRKAPDPKVPKKRPEKRPKKGPRVEVEYEHEMESVPLSLANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0L8</accession>
    <name>A0AA38L0L8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fruit-body specific protein a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_411569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0L8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041241994" description="Fruit-body specific protein a" evidence="1">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23347" checksum="76857A9D898D7BC0" modified="2024-01-24" version="1">MRFFAVLTAAVFSVVLADSDTAASAASAAASAPSSSAAALSASPFTNATLQLSLSNSLSQSNHYGAPIPPWEVGSYPGWYYGQDPGAIIGWVLPWLLDTLICDILDLLPFCLHCPIPKPPPKNGWVPTFSNLTGATQAGDYLTYGLVDTIQDCETMCLNVEGCIFINTYHDVNGKNGSPQLTCSLFSLCHDASDADNKGGQTQPDGSVDYITDSNGFCLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1K1</accession>
    <name>A0AA38L1K1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794206">
        <property type="protein sequence ID" value="KAJ3779797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1K1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="482" mass="55494" checksum="2D28BFDEA583D65B" modified="2024-01-24" version="1" fragment="single">NYLQFHDSEYDRMEILEPFLESWHTIWTNLSRIYEAHWVGLPSGDPSTLGFGANLLNRKAPGNVSKVDYHRYTDLLDVQLEARILDIWRIAFGMNDLYQDMERLFTTKELPSFDSLYVQAIDLCHRFGTLSAYHEIMTSGEGYEAGTHWNPMPSHRSSLHLGMQPSTKFKKSQYQSEEFCGDETLARSTRLIYDSMISRLATNATRRGDVGCLWECLKMMTFSFAGSTHTKYTSYLLEMICNFELESSPELKNFFLDNWLISRDGRTYEAGDLFQEHLQNELYEHINHDQGFDNLHVRGKLSPNVYRFMQTKKVHHTSLGLAPRAGHHAAPSRRTDVRKLMLHYEREELHLFWEGRTYKEENRDRVDDHGRGVSSLMGGRLKRWINDTLWARGLNGKENGSEGQGSQALDVPVEGCQAFDVPVEEVGGTNGTLKADGFAFDPNRRNVAFAMSEMLTVDDDEEPLEPLPSVHIEEQEDELMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2K7</accession>
    <name>A0AA38L2K7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_232407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793857">
        <property type="protein sequence ID" value="KAJ3780205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2K7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="124" mass="13830" checksum="8E11ACCBE9E8FE9E" modified="2024-01-24" version="1" fragment="single">IGDPLAERLEYILTQHAPFPGESVNSIEIRSLERFVAYRISNQTHLLIDSAGEGKEHQIPTHFLVNPDFEPCSWFARQSGDSSAGRHNPSQPMGDAHATRVSQILNAAVNYPGDDLPEFHPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2Q1</accession>
    <name>A0AA38L2Q1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793754">
        <property type="protein sequence ID" value="KAJ3780400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2Q1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="431" mass="48759" checksum="4F1AE1E45C034399" modified="2024-01-24" version="1">MAVVIKSHSGRVGRQYPELGWYITSPNSTRLLEPLLGKQNICLCQNYLYSEHDPLLMPQPHNIHVPHLPLILNPSIPSEFGILWIVADLLKALEQTYTNIVLKIANTSSSSRPSARSDHNVQTYRRRFQYLSGYFKHTASSYSESLMAWSICQCICLELNARITWVQSVAPIWGKMDAWRVPVVHNVVGALTDNAEVAEKCFRSGIPVWLYHKLPVKPDIKVMQWHTNKIPVETVKGHIKQFVSFADADPPQPIIYTGNVMSLDRYSRMAENNNKIAFPGSAFDSIDPVTHPSMPPSIPAWVKACKQIGESFVQSQQPREGVPRGYILPEHGMLGSMDTKLRQKFLRMYLKLKPLLFYQIQKIGMVESLLSTSLWRKVLGMESLGVTNGTRAAETRQSLIHELQTTLMGSNLTINLNNLSSVVPTWKKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3E5</accession>
    <name>A0AA38L3E5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoaspartyl peptidase/L-asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_277450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793551">
        <property type="protein sequence ID" value="KAJ3781510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3E5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="8888" checksum="26B5F2C05DB3DF6B" modified="2024-01-24" version="1" fragment="single">QYFIRQATASTIARRVQLLGEPIATAAQVAVESLRRDGGVGGVIVLDSEGNVATPLNCEGMYRGLIREDGVPKTAIFNDEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L580</accession>
    <name>A0AA38L580_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_350370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L580"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="56"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="508" mass="55105" checksum="50B427FE477DE1B9" modified="2024-01-24" version="1">MSGASSGDKLSNTVIETNSDSKPPSSKTNITSPKDFGFLPVPKRLRYDPDNPFHFGMFLNILFGVTSTFSVANLYWCQPILIELSSSFDVSYNEISKLPTLIQAGYATGLLFISPLGDLVRRRQLLLILIIVSASLTIGLSLTPNLPAFQILSFLVGVSSVTPQVLLPLTADLAPPSRRATAMSIVFSGLLFGILIARVFSGLIAQFANWRITYYMAIGIQWVLVLVLFWNVPDYPPKNAGKDAHGEDGKLGYGKIMWTMVKFSVTEPVLIQGCLCNMGSAAAFSSFWVTLTFLLGGEPYNYSTLIIGLFGLIGMVGVALAPLVGRFIDFLIPWQASLVACIGLLLFQIVQVVGNGLNIAAVIIATVGLDVFRQMLETSLAISIFSIAPHARARLNAIYILSLFIGQVLGSSAGTKVFLTYGWRATAAMTLGFTLWALIILLMRGPECERYTWFGFGSGLRGIRDIVCGVQDLHRSTGRSKAQLEKSVNGRSDAGGQRDIGEGETEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L593</accession>
    <name>A0AA38L593_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_428210</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793357">
        <property type="protein sequence ID" value="KAJ3784960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L593"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3784960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="139" mass="14950" checksum="E40D7EFDAFBC4A5C" modified="2024-01-24" version="1">MPPRSKSGDKGPSEGQTKSTVTRSQKAGLQFPVGRIHRYLKQRTQHNVRIGAKAAVYTSAILEYLTAEVLELAGNASKDLRVKRITPRHLQLAIRGDEELDTLVRATIAGGGVLPFIHKSLTAAASKNAALAAKKPGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5J7</accession>
    <name>A0AA38L5J7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5J7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="323" mass="35243" checksum="AF7DD55E2BA6AF2C" modified="2024-01-24" version="1">MAVGLAKLDLVSVFVECVLYGFFALLAIIAFSIVLQRRRIKHQKPRGTLRILFAVLVMFLLATVHLSVHFHRTLYAFFGPGSSNTTTEKINSIGKVDGILVSIGSVGYTLKTTSYYLQTYVGDAFVIYRVYVVWSGNTKVMVPLIVSFLASIGLSIYVLQEMGQAAHGDTIFESQLYDFILSFFVVTLFTNLGSTILIAGRIHWLHSQVKDASRVFVSCPLFGTSARAGCSAIFVATVISESAAIYSATLVVILILYALKIHTVYVLIDAATQLIGIVFAFVVIRVAIGVSTEATPPVRPVVEPDSSVSLSEIEDKSIILEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6C8</accession>
    <name>A0AA38L6C8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_155033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6C8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3787105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="495" mass="55001" checksum="DCCC1896D754D82A" modified="2024-01-24" version="1">MASTVSVPSMPEKETQSDFHSKLEKGSSSSLEGSEVPEDRLMEARVWRKLDSRVLPVIAMFYLLSFLDRTNVANARVAGLQTDLKMSNKEYSIALTVTYVPYIVAELPSNLMLKAVGPNLMLPTMLTLWGIVTTLQGVVKTYSGLLACRFFLGLLEGGVFPGLVLYLSYFYPRYKMNMRVTTFFSSASLSGAFSGILAYGIIRMNGVGNRPGWSWIFILEGLFTFLFGLSSYFTLPRSVDKTWFFTQEEKDYVNAKLLADNAQKDEDGFSWNEVWEALKLPQLWICNVLFFCSGTILYGLAYFTPSIIQSLGYTAANAQLMSVPPFAVACVVSIIASFISDRYHCRGIVLIISAIFCIIGFAMFLGSKSTHIQYGSLFFSVTGAYTAAPTGSAWNANNASPQTRRATVIAFGFVMTNSGGILATWLLGSLSPAPRYTKATITLLVLSVVAMVFSALNLWYLWWQNGKKAEARKVVRREEEKLGLGNYSAWYIYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBF4</accession>
    <name>A0AA38NBF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_321111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793634">
        <property type="protein sequence ID" value="KAJ3780886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBF4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000312">
        <property type="entry name" value="Related to Cell division control protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="26"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="425"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="488" mass="54706" checksum="57746421D497F5FD" modified="2024-01-24" version="1">MSSSTLSKYASSKTPGVDLYGGSSSRDFCNSFWGEEGEAGVNVLFARMRGAQRTMEGMKVFWKERAEIEEEYGRKMMELAERSVGKDEIGEMKNSLRTLGMETYKLGETHLGLAGQIRRDNEERCGEMLKRLVEWRKVKGGMVEKKYKTKLAQESYVVKAQEKYYNDCVRIGMYTQQMKKQGEEGGEGVSEGQKAKMKRIEETVGANEKDYEMFVKGVGEMIPGWEKEWKGYCDEAQDMEEERLDFMKDNLWAYANAVSTVCVADDESCENIRTVLDQLETEKEIIGFVQEYGTGNMIPNPPQFIPYSTSITKTNSARQAKFTRASNKNAPPYATSPPGPPPSIPPPSLPQQQQQQQPTPSTQPQPQPQPTTTRTPSAIERRSTLPPQPIENGSGNGNGNEGPVPPIPANISTMGTTGMSTSGNKILFYVEALYDYTATIPEEFNFQSGDIIAVTDIPDDGWWSGELLDEERREEGRNVFPSNFVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBK0</accession>
    <name>A0AA38NBK0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_367019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793568">
        <property type="protein sequence ID" value="KAJ3781366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBK0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="168" mass="18814" checksum="B2B1E29B56F774D2" modified="2024-01-24" version="1">MQFQLFGTGLDLKKACIFFVLGFAFITYVAALPLPGQDAHSTSTSTSFTELVRRSEWTAQVRYHENTMPWATSFLVNDIHSKITGVIQGSHNVPIVIEFPEHQGEVPKWNENNQILFDYTLFRHDPPPTQWTGSGSTIHQTFTGSGAIRKVQVGSSYKIEAKMNTPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBW9</accession>
    <name>A0AA38NBW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_84385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793490">
        <property type="protein sequence ID" value="KAJ3782236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041318331" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8645" checksum="D785F25DE6FAA115" modified="2024-01-24" version="1">MGMFRTDLAFVIFLVLPAHWRCSTCSYTCNHFQQWLNYRISLAMYYIHIILLRFSGEVVLSSQKFKVPHAKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCA3</accession>
    <name>A0AA38NCA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_56939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCA3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041302073" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="384"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111227" checksum="1F79A841A42EA982" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCU8</accession>
    <name>A0AA38NCU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_269907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="708"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="828"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="862" mass="97262" checksum="51380BEE63D59B09" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND18</accession>
    <name>A0AA38ND18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_421971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND18"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="156" mass="17672" checksum="B2417C5AED9BD7B0" modified="2024-01-24" version="1">MHNVLPNQCISATGISKSFIFGSLVAIAGSQLRLACYRILGSYFTFELAIRSNHRLITEGPYSYIRHPAYTGLIMTMVGEAIIQFGSGSWLRECGWTSFTGFKVYATILLLQMSMISFSVATKRAQNEDEALEERFGEEWKTWATKTPYLLIPYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH87</accession>
    <name>A0AA38NH87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_381447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794031">
        <property type="protein sequence ID" value="KAJ3779957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="189" mass="21159" checksum="5B29630D9F38845C" modified="2024-01-24" version="1">MGQAHYGLDDVAHGTHIAPDAVAHIQQVSLCWQAFMGLVHPVLHSKLPAPNMNSNGTNMLIKVHFWSFQAEMVSQFEGFELRTQHFLMHIFKLLGMQLVEHLHIEGQVPTYQNPHCPCVYPNVKKALWAVLINSVRSNMHIISVLETGGGKSMVFLYAPKLIPGKPFIVVSPVRSVRIEWTFGTAIVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHM8</accession>
    <name>A0AA38NHM8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_379682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793577">
        <property type="protein sequence ID" value="KAJ3781292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHM8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6532" evidence="3">
        <location>
            <begin position="251"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="473" mass="52902" checksum="C31415C0D9D1BCEB" modified="2024-01-24" version="1">MKKRRAPTKHTAGAASAQANLKGSSQYRAVLIDVDGDESLAEDELPKKKSRQAITAADIRTNQCEEGEDGESHSEDGDLNMQDDGPAHDLNASCHLESEAVIITAMSHIAEKDKAVQPVVTVPIRLKGNQISTGRSMRRVTQLAYEVVSIFSSEFLLIFHIFSSLRYQNERFPYLALPKADLRLPLLLLQQFPVTSGWSPLVMHNIIQRAINLGKIKMLFDHSFSPVGPSGLKQIAFAALDEVANKEGYDGQGDVCHRLAEGDHNSYMKPLIAYVSHRVGLDRSQLKDLSAVVLNAFGLSRQSGAGPATNLIQKCTYFYPVIDGVLDETRRYDYQRPFEHPVFSAFISAAFFSTSTYSNIVREQCNLFRCSLHEYDKQHENEVPKAMVAWASVVIHACLQDFASGVKESFPSKEVDGIWHLSISLLDGIEKANRRKFHKLMWNFYWDAIGQPLTNHSITNQQAYDKVDWSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIQ9</accession>
    <name>A0AA38NIQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="5">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_357991</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="5"/>
    <dbReference type="EMBL" id="MU793379">
        <property type="protein sequence ID" value="KAJ3784367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="725"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3784367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1462" mass="160623" checksum="1C5FD9325BFFA49B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIS4</accession>
    <name>A0AA38NIS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_230451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794680">
        <property type="protein sequence ID" value="KAJ3779539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="23294" checksum="E79CCD4EE0FCD87E" modified="2024-01-24" version="1" fragment="single">MPRPMPRLFIIRHGETEWSLNGSTGRTDIPLTARGEQQVIEKASILVGEGRPIDPKNLCTVFVSPRQRAHKTFHLLFSHVEMPNHILTEEAREWDYGEYEGLLSSEIKVKRPNWNIWLDGCPGGESVEDMEKRVDRIIANVREYHRQYHEEGLNTRDVVIVAHGHFSRVLISRWIQFPLRLGTHFNVEPGGVAVLSYNHNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ95</accession>
    <name>A0AA38NJ95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lid2 complex component snt2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_367727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793600">
        <property type="protein sequence ID" value="KAJ3781128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ95"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="7">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="190"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="708"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="978" mass="109355" checksum="04D5A8DC138CF5DB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJB2</accession>
    <name>A0AA38NJB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_118497</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="MU793587">
        <property type="protein sequence ID" value="KAJ3781218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000008">
        <property type="entry name" value="Probable NUC1-dna/rna non-specific nuclease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041361699" description="Endonuclease" evidence="11">
        <location>
            <begin position="23"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="13">
        <location>
            <begin position="91"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="12">
        <location>
            <begin position="92"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3781218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="352" mass="37973" checksum="3E621265D4AB1A9D" modified="2024-01-24" version="1">MSSLVQAALFAAGAVVGGGVTAAVLSKKQPALTPTVDGTIVSPAVATVTPPVIGLGANGNAQITNIASLAPLSSSAVLKYGNPGPVADPIIRRAYVAAYDRRLRHPAWTAEHLTLASLGKSSLVAPPDEAGDRTKSSFMEDDTIPAPFRARLVDYFKSGYDRGHMVPAADAKFSQEAMNETFYLSNMAPQVGEGFNRHYWAYLEDWCRRLTGTFSDVYVFTVPLYLPRRDPDGKWRITHEVIGSPPNVSVPTHFAKVVLTSKPASPSTPNILELATGAFVLPNAPIPDETPLEKFLMPVEAVERAAGLALFSDAVKSTSKHICQSTKCEVIVRRFDDTRKRPDMRRTISAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJX4</accession>
    <name>A0AA38NJX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_390457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793535">
        <property type="protein sequence ID" value="KAJ3781654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJX4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="428" mass="48297" checksum="D6EE445FFE839762" modified="2024-01-24" version="1">MSNKYRLALSQSLLISGERSLQKLWQDQSNPFWLPDDVVHLILGYLDTHQLEQCTHVCRSWRCIAQPMLFDLVTVNAAPAPPRIMNFFSVHTRRDFPSFILANPGRGLLFKHLKHTTPSNDAASLYAVMPYCSLLRSLTLSCALAPPFLQHVSLQQFPLLRTLVLTEISAFRIVVDCFRFVSAELLEELSLSLAKSYTERSVDVPQRQPCLPAIRTFSLFNDNESPFASFSLLLDYLFPILLRLRRLVAHTIHFHSPDIVRLVEANEGTLKYLDSSEVLGPSDLLPRLLNHGVLQEITLCLPVLPNILGRYLSDLGTMFLNLNLDNSPLRRISFVVSSTYGLLDLGQHSDLWAQLAGILSRAPYLEMVTLLLEVPPWGQSSMFVTKNDLSVHPAFNVLREVGRIEVIYRPSPGRKPSVILPSEFVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJY4</accession>
    <name>A0AA38NJY4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_365901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793532">
        <property type="protein sequence ID" value="KAJ3781699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJY4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041225026" evidence="3">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="15534" checksum="EB8C4EB423C348F9" modified="2024-01-24" version="1">MLGLWPTLNFLVVFCHLMHGIDATPLVARRACFDENDNPTACPQAKWSKSKIIIICTIVGIVLILMIASYIVKYRRTQRQIIRPLARPLTVRAYPQLDSQSTFLPRRSESPQKGQALQPYVVSESDTSIVPPPPAYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK60</accession>
    <name>A0AA38NK60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793466">
        <property type="protein sequence ID" value="KAJ3782583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098754">
        <property type="term" value="P:detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="245" mass="27463" checksum="1529B416F5808678" modified="2024-01-24" version="1">MALLEPLVLYTAKICPFAHRVELALAETGLKSNKDFERYEIDLKNKPEWYQPKINPASKVPAIAYGGPKVTGDQPSSESTKLAESLVLLEFVADLFPNSHLLPKDPVLRAKARFFIDAFANKFAPASFAFQGGKSTNGAEGIFSAIEQLQDLMAPEGLAIGDGKDFTIADAAVVPFFARMEVSLKNDFGVYPEGEGKKAWETLQTDGRFARWRKYWETVKARESFKTTFDEDYLTKQYSTRWTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK83</accession>
    <name>A0AA38NK83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ELMO/CED-12 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_266138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="353"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="769" mass="86449" checksum="EA17CF716D481DB1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKV5</accession>
    <name>A0AA38NKV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_135613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKV5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="261"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="526" mass="59600" checksum="F5BAF3A320448FED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM02</accession>
    <name>A0AA38NM02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_354195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM02"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="298" mass="34072" checksum="249DD34430315447" modified="2024-01-24" version="1">MYPSSIDSEVFVTHPSLHIRDAQDAHVVLEAVRLRVLPLIKRGLVASERDNLSTGNVFVWEEAEDEGGLLRWTDGRRWSQSRMRGDYLFYEEKVETTAAEKEAKAARRARRASDPAAIIPPPLRRKDRPTKPDGLTKQTYSALVHLPGTNETRKWHVVAYFSGNDYTRLPVIENYDYLRRIRVPEGVFVNSKSLTKMDTPDSPLDEARDLEHRRFIESYPLRPVSPARPLYPPVFPPPLAPPMPGDPRQRVSLPPISMLDYPQRPGFLRHNSTSSANELYTPLSSEDQRALSRLRINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMS1</accession>
    <name>A0AA38NMS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_308988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="523" mass="56030" checksum="F6B50C4EB9C8ABF2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMT9</accession>
    <name>A0AA38NMT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794431">
        <property type="protein sequence ID" value="KAJ3779660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMT9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="376" mass="43854" checksum="63793A86855739FD" modified="2024-01-24" version="1" fragment="single">MDLFIGSDSEEPSSPQQYNRRSHRLRELRHRRRVVSDMDIDYDENVESTNDETHDVVMQEANDDSSSSMNDDNIENDEVDSDEEFQIYYEDNAEQFEIDNDEHADEDYEEEQEVFEDPDTNVNMDDDDTFDDNQSHFPRLFSPELGEGSNDDPYLSDSAVEHRSVWVYTIDMQRHLDEFSELSAKEAQKKKKARSEEHARFWADKKQHGLEDIKDRLERFSGDKATGKLQSFSDEQIEDMEKFLVEFDLSFLNSQAYYNEASHEKVEEEEYSIAPSSPPSSNLPHDLDEEVDRLLLDKNFTYNSAQYQLRSRDLHTLNPTRWLNDNVMNAYISLLSSTTPPNITIVPSFINSAIRTARTAGMSMRKNEALFRLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMW7</accession>
    <name>A0AA38NMW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_138820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMW7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12524">
        <property type="entry name" value="RRM1_MEI2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12276">
        <property type="entry name" value="RRM2_MEI2_EAR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034453">
        <property type="entry name" value="MEI2-like_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="617" mass="66228" checksum="652A9FFF6A8AD031" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNE6</accession>
    <name>A0AA38NNE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fruit-body specific protein a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_373272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041449956" description="Fruit-body specific protein a" evidence="1">
        <location>
            <begin position="19"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="53367" checksum="C8B56FDDF4325D7B" modified="2024-01-24" version="1">MLSLARLLTFASVAVSLAECSGLVAPAYQGVPATVNDPPDFNGTSTDSSSIASTALQVDQKSGATGDALPDQPVPDTTVTAVDGNLVNATIPNPSRRGLAEDASESSLMRRNNSNYELVFWGTGTGSNDRDAAIEGTAYLTYTVVSNATYDIDDCLAFCDSVDGCVFANLYYEFFNPLLDFVFSQKSNLKCALYADVHSAAEKTNFGGQALYPSPGPLNFIQQSSGWAAKSLVDPTTPPGYTQTFGPTNGANNAPGYMGFAFIDKYDVQACADLCDTRGADPVGGVCEYFNIWRATVNGIPTTYTCSMYFIPSDNSTAVNFGQGDLLVTESRGYKRNSLIIDGGFEGYTCGSSSSAEFPFCFTPGYSAWQGTSSPNGNFDASIFNYQPYAHTGSAVALLGSAYGTDNLPGTLAPTVPLVTEAGQSYTLQFYHSSFYSGEQAEAPATLEIIWNGQSVDTIHPGFSQWTVHQYTVTAQGNDLLQFKGGASPAYVFIDDVSLFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNH1</accession>
    <name>A0AA38NNH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proteasome complex subunit Rpn13 ubiquitin receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_346459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="166"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="280" mass="30278" checksum="E3389B5EAF0A531C" modified="2024-01-24" version="1">MAESGTLLAFKAGRAFRREGTNFVDPSPTKGAILLRKEDDLLHLIWKNRVTDEVEEDLILFPSDATFSKVSQASGRVYVLKFSSSDQRHFFWMQDASSARDEEFVNNVNGFLMDPDHEASWGPSSQPEASTSTAGASSSSAPSGFQASPEQMAQLQQLLSSAVGGGASAPSELSLNDILTPANMTALFTSHPDLIPTLFPHLPPDLPMPPSSEVLQRIISSPQFRSAVSNFDQALRTGLLGGLVRQLGLPEEAGTGIEPFLRAVQRQADQERGEDGMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNJ9</accession>
    <name>A0AA38NNJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_127142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793632">
        <property type="protein sequence ID" value="KAJ3780905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNJ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="143" mass="15458" checksum="AD655F2F1F2F64FF" modified="2024-01-24" version="1">MSLGEADAKFPASTHSGSPDFPPSPTAENPGQVYPKSDPHAARSGTIPGTALPNSSHVYIGNPFLMREAFSKVDHALGNVIEILESEETSVGGSEDENNLLTKFRQWREELDEIRAGQRTPSSSKSRSSSRVVPEREGGMFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNM5</accession>
    <name>A0AA38NNM5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 type zinc-finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_285943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNM5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="464" mass="52463" checksum="25BF158B4098E0F7" modified="2024-01-24" version="1">MEEQEHSKHLFTCISCSIAFVSAEEQRVHYRSDHHRYNMKRRVAGLPPVSVAVFNEKVNERRMETAIMSSLKGSMCEVCNKTYSTENAYRSHLNSKKHKENELQASLKLAYKLAKKDGLEAGPEDEVEAKTVEGPPSSEMASLSISEESRSKETSTSLVVDDSEEEQINQTIDQKIAAARSRLSPAHCLFCPAESSELQANLLHMASVHSFFIPDADYLVDAEGLIGYLGEKIAVGNVCIFCNEKSREFRTLDAVRKHMLDKSHCKVAYDKQDDRLEISDYYDFTSSYPDAHLRKKKAKAEQEKDEEWEDSDGDVSEVDEIMEIEEDEEESEISDEDDPNGQATYGDSQYELVLPSGARIGHRSMRRYYAQSFPGTSRDVDPNSGAAIVRRLLGDKNSLLVPRKGGFGAFGAGTDVVKARNRGEAREAGRHVREFRDQARRENFKTKVGFRHNSQKHYRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPE8</accession>
    <name>A0AA38NPE8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Microtubule associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_27012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793373">
        <property type="protein sequence ID" value="KAJ3784520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPE8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="765" mass="85044" checksum="D40D42A74055AA0F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPK3</accession>
    <name>A0AA38NPK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_375906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPK3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041452793" evidence="2">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="83" mass="9336" checksum="22E3754307A1E474" modified="2024-01-24" version="1">MSKQVILLLFTVLLLGLFTSAAPTPVERKALKQLKLKRGGPEPFMKRDDAPKPSGYVAKRDEASRVVKRDEPSAPKPSKWYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQG0</accession>
    <name>A0AA38NQG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_330142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQG0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="37034" checksum="C92C9AEE193610E1" modified="2024-01-24" version="1">MSSDNALFNAEALIRLEEGEKDVDSDSSDSDSEFESDSDSDDQPVAHTQLELRRTRSQTSQLSATSSPSLSSSTTSSAQFSTTSSARSEEVAQLQIEIAKLRQENAGLKLESASIKAQRDAAQAHAVFAGQQVAVFKHRYNSKVNKKESSKRVTTSARVLTSREVRKEIKEDAAKKVQRQKDEAERETRKAEAEKADIIRHAEQERLGTQFSGNMNSMSKKALVDIAFSLKVPSEDVTQDALHVRLKAHFDAHEELKKHPRYIGIFERTRKRKDPPGGSNPESSSRAPELSSHTPDLSSLTPGPSSFAPGPSLYPLSMHHPSFAPPPFFESQSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQY8</accession>
    <name>A0AA38NQY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_260551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQY8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="376" mass="42639" checksum="226B74AFD7B52929" modified="2024-01-24" version="1">MFSTLDVEIRPGSGLGAFELGASLWNIIHMLRQMQHLFPQVEIKYDPDTSSTTPIILHLRPHLDLLFSGKHQRLRTICVRRLRDTSPPVTLRYKDVVLSSADEVLRRVGTSRTFGPTYPGDDLRYPGVWFGFEEDGIGEGRKGAVYHEDRSQEVKRVLISQKEVDTEEGDALGEIVECPIMNGDIALAIAKVHDGVTLHFHPSTSTPVHVRIGTTTAQDLAVILGPPLHVHYKEDDRMTIHSSLHDESDTGYFYNYFQHGIDFYISGNTHTVQKIVLQSNVPGTPLFQVYKRCNWEIEGKPEDDEDDTPPRKRFYDRFETISHFLNPREPPPSMLLDRTNDEENITLPSPATRLYGYDGVILEVSEASQVLTITLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRI4</accession>
    <name>A0AA38NRI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_342793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRI4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24029" checksum="6F5095DDF8E744DD" modified="2024-01-24" version="1">MNSSVDHLSPTTSSARFSLPSKPSPGPKPNIYERNLNKTRLSEVSAASLSFLFSEIVQYTQKRVSGINDLERRLNTLGYRVGTRVLELTAYRAEFSSKAPKREIRLLPALMAIHTQVWRAVYGRPADAIEKSVENVDEYMIIDNDPLIERHISVPRDLSGLSCSSFSAGIVEAVLDGLGFPARVTAHHTPTATHPTRATILIKFEKSVLDREDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRT3</accession>
    <name>A0AA38NRT3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase of plants and bacteria-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_383683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRT3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="323" mass="36526" checksum="CAE6ECEB51B3EFDB" modified="2024-01-24" version="1">MGPILSKTVMAPVDNPENKDPWVLPQLDFRVEDLSHPGAKLFFRQIPNPYDATKRAVEASWKWLYGWNESSDIQHGKNSQMPVVTPPLAVRRVKRITLTIRPMDGVAYTFGSDDGSEKEVHFSLNHIVNSHKGDTDIKKDIRVREEILGVLVHEIVHCYQYNGQGTAPGGLIEGIADCVRLHEKLSPPHWKRAPPKGKHVPEPDGKWVWDWNWDAGYERTAYFLDWIDTTSETWPNSPYTRQKKPEPNAMSSTRSAPPPSASSIPIQISPSTLAPSPPLGKGLFFRALNARLKDAKWSSEMDLFLELTNWPRDALWEAYCAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSW9</accession>
    <name>A0AA38NSW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_302854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="441"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="791" mass="89952" checksum="65E3BF1F6A1E3BC5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSY9</accession>
    <name>A0AA38NSY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_340276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSY9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="635" mass="69647" checksum="9E0B3328E0255AFE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT34</accession>
    <name>A0AA38NT34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily multidrug-resistance, DHA1 sub-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_416196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT34"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="463" mass="50144" checksum="7F81419AD2B02B64" modified="2024-01-24" version="1" fragment="single">METTPLPKLQLFLTSLIQLSEPVTGMVIYPFITRAVRRTGITEGDEKKTGYYAGVLESTFFLAESLSVYPIGRASDFYGRKPILLIGPLGLSFAMLSFGLSQTFWGMVIARAAMGMFNGNIGVSKTVMAEVGTDETNRADAFTLMPIVYTIGSTVGPTIGGILADPATRWPHIFEKLAFFKQYPWFLSCFAAGLLAFVAFLLSSWGLKETLPSIVKEKKIAESSPLINDLETSPLYGSVDNLSELVPSASEAPPTTGALLRDPKLMVSLLSMGFLAFTDMSYEVLIPLIYTTSIPVGGLGLSPYQVGLILGIFGFANGIWNWAVLTKVLKKLGPRRTFVICYAFFLIHFALLWILRDVAAYAGGMTPLVWTLLIFQLFVSTVIVTAFNAMHLLIVMNAPPNALGSVNGLAQVVSSGTRGLAPFFASSLFSFSLESRIAGGHLVEIVLMVITVVGIFCTSRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTK5</accession>
    <name>A0AA38NTK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_281284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="533" mass="58777" checksum="BB4D74DA580EF264" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TXX5</accession>
    <name>A0AA38TXX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_406362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TXX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="930"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1169" mass="132485" checksum="562204AA601581AE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZF0</accession>
    <name>A0AA38TZF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_303844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="224"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="1159"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="940"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1328" mass="142333" checksum="502778AFDAC84E92" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U173</accession>
    <name>A0AA38U173_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_338501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U173"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3791035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34113" checksum="3B5AD66155D8410D" modified="2024-01-24" version="1">MELSHTPLRRSIRVCPIIQAVYHHPLLITLSEAFTLSIYDLSSGSAALTQTLSSFTSFPPTSLVLSTTSTATYKLVLAYAIPVYPAHWSVGATELIIAGPASNCELPHSSSFLASTHTPMTIISTRTARALDVPQGWVDEKKLRLMREQWSRKVSRVADTQTDGKFVVLAPEDLGSKPYASLASSPSSSPSSTHHASTLYSPTGLQLYRLSLPSSTSISSSAPKLTFVRTLHGQIGPVAALALSDGRCVSFGVNGSIWVWDLESTSGTAVATTMTDRSFDDVHRLANAKRSVVFDERRIVTAVNERFVERRFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1K2</accession>
    <name>A0AA38U1K2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_338232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1K2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="465"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3791232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="649" mass="70131" checksum="BF63259CACB54DAF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1N4</accession>
    <name>A0AA38U1N4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PapD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_370555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1N4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902647">
        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3791275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="324" mass="35529" checksum="1B38857CEB818D71" modified="2024-01-24" version="1">MSVYLNPSNSLGFNRPLTTLVKRALTITNPHAQPVAFKVKTTAPKLYCVRPNSGRIEPGSTAEVSVMLQPLKEEPPLNAKCKDKFLIQSTLMTPDKEQKALHEIWTVPEGDSDDAHKIHQVKLKVVYLPPEGQVLEEEDENMVNQSSLITDPPQFDTVRQYPIVNGHEIPEFSQQGEPSTLPQQEDEEHHDAHEEVPVPPVSVFIQPPETSPAPSDPAVPEPAPPAPAPAAAVALPPAAPSPPDFTEELMVARAEIDRLRSLLAAAAPPPELRKRTRRLSDDITLAPSDVGTMIDESTMPQEGVPLQIVVIISLGVFIMTYLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1R4</accession>
    <name>A0AA38U1R4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_158348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1R4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="52444" checksum="C1F6E4354F2804CA" modified="2024-01-24" version="1">MVATISPPLTSSSQSISSEKLNEWTLLGGEPLKDTPLCATMEVHELKNAPIMTRDAFSRCESSTTQYGVLGRVLGCYSKKEISTFQDSRVYLNTNTPMSALVCGVQGSGKSHTVSVILENMFISSSLLGTLAKPLSGLVLHFGEGGPGSGPCEAAWIGVSNHSSIKAPPVKIYVSNSSLNTMKGVYAPLTQKGNVTVAPLLFNESELDAEAFLSLMAVGSSDNAPLYIQTILSILRELGESFSYQAFMTALELKKKTFNPAQLAGVEQRLSLLNSFMAGKKTKKLRWEASTERKCRFSPGELTIIDLSDPFIDPASACGLFEVLTRLFVRADVGTGKVLVVDEAHKYLSSSQHPSGFTKALLSLTRQQRHLAMRVIISTQEPTVVNPVLLDLCTVTILHRFSSPAWWSHLEKHVSAEFSDNDAFDKVVRLQTGEAIILAPSGLATFTSNTNEHNVGQIGRRYLIVKTRKRVTVDGGASIRVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U745</accession>
    <name>A0AA38U745_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_340608</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U745"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041320025" evidence="15">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3790365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="512" mass="58292" checksum="CB3FE965A5C1B060" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8P6</accession>
    <name>A0AA38K8P6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_318537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793475">
        <property type="protein sequence ID" value="KAJ3782454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8P6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52450" checksum="6AE2CD61C655DCC0" modified="2024-01-24" version="1">MVLNTLEVLGSKYFPTQYTLHIVIAISIIFALRAYSQGRATNRERDLHARTILVTGGFTPFTLTIIHELAQRGAHIIALSPNPIDSPRVSLIIDALRTTTSNEHIYVEHCDLLSPASIQSFCKRFLSGEVKRLDALLFTHEYPHIGALRHFKSKTEEDAQREQLSLASFLLTTLLLPSLLTAPTERDIRIINVVNRFYAAASSPSFSSAFYNSLISNEVPPANSIFLAEGTRSLRTIILTRHLQRILDALPAAHIPKTDSQSSAIPVVNPDSQKSNIVAVTVSPGISRADTVARILNADWTSPAGYSKFGVILYLSFLPLLHLFTKSSVAAVQSVLHALFLPTPFKLLSQTTQNQPQAKNDSLIDKTLTDLPEEVLKPGALYAECAVVKLKVPPPPLEEEDEKRASEDKGKGKAAEKETMDLPDDGELGGELAGRRVWESYEAALKAWEAVNPTLEEMEAEAKAAAEQEAIQTEGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9E7</accession>
    <name>A0AA38K9E7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_377065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793391">
        <property type="protein sequence ID" value="KAJ3784074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9E7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="577" mass="65884" checksum="43A282A644AAD7A2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9G7</accession>
    <name>A0AA38K9G7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_376964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793386">
        <property type="protein sequence ID" value="KAJ3784209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9G7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="254" mass="29385" checksum="9AF82406DD99AEE1" modified="2024-01-24" version="1">MTRDSMVDVRNRVHFPDLAHLEILSPVDYDWDSNPISLFCAMIERDWHSHLTHLTLHAISFLPKDLLRFFLSASSVTSLMIMESSKRHAGCVFTILQLLIWPGYHGPLEDQHQSMNYSGEGMQEYDGLDNDESDENLLYRYWLKNGHERSIDEISKLNGILPRLRELMLVFPPLNDILAKLLRSRWRPFSLLEKLPPSRAGSPVHSDDEVCVSLQKVRIQYPGRVGKRAPTRLRTLRDRLPPFREDGMDVGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9M8</accession>
    <name>A0AA38K9M8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_357502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="MU793372">
        <property type="protein sequence ID" value="KAJ3784554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9M8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="1 4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041488252" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="30666" checksum="A93A8C38C85B1BF0" modified="2024-01-24" version="1">MYRVLLLALTLLLSSWNGLVNAASQPLTQISANIGPNPNNVGMFLYKPTKLASPLPLIVAIHQCTGSAQGYFESTQYANLADQYGFLVIYPNSPRSGSCFDVNTPQTLSHNGGGDSQGIASMVSYAISTYGVDPTKVFVTGTSSGAMMTNVMAGSYPNLFAAASAYSGVPFGCFAGASSWNSQCSEGQLIKTAEQWGDEVRAAYPGYTGSRPKMMLWHGTADTTLYYANYGEEIKEWTDVLGMSQSPTTTTQNDPQSGYTKTTYGSVVVGYSAAGVGHTVPVHETIDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9W1</accession>
    <name>A0AA38K9W1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetylglutamate kinase</fullName>
            <ecNumber evidence="6">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_356143</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="6"/>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3785004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9W1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000046">
        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 19" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 19 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 19" id="KW-0521">NADP</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="21">
        <location>
            <begin position="333"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3785004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="886" mass="96686" checksum="D6BA66F9E0416D43" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA04</accession>
    <name>A0AA38KA04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_387690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793351">
        <property type="protein sequence ID" value="KAJ3785154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="488" mass="53443" checksum="6EB58A4DDF7D8665" modified="2024-01-24" version="1">MQLPSSPKCLCQYLVPQKILLSLVTGTSSGVQLARDANLLIRTYIPSSLSLHQPYIGPPIPLPFCIPQVSVNPNDQSTFARGYNDALNDIGIPQDVFLNFIDGLNMAIIASPPLRVVDMAGKIIGFIPYHWAMIAGALISTAAGVAMHVLSKTLTDRYLRAANLNLFKPRGLSVRLCTTPAMFALLASSESKARSKLNKFGRGVGSVLLKLPIPVINPIASTIIHAIADKPPVISPSGREGDPINDPVLRRRVAMTEGLSLPLNMDGLPPPSKPDGVIDTMASWGVRFDTAREKFSEKNIERRRRALESIKQAGIEPPSRSMGLLGAATMMSSRSGLQPTSSTSVRSTSSSSMLIVGLQKEIRDERIEQQRNASLRNSGLGNVGLGAILGSKKTRMEQKVADADLLEHWGTDKILWVVIMASDKDEEIADIAIAEDPADEERIDDTTWRERMAIERNEMELEDMQVFEQQQRQSQEVFTDAEPSRNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAE6</accession>
    <name>A0AA38KAE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_181816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="225" mass="24404" checksum="8089239906566685" modified="2024-01-24" version="1">MSVPTMMDLVDLSHPLDPERMSIPPGLPQLISCPIATVPKDGFSMHTVSFGSHTGTHIDAPSHFIADGKSIDQISLSALVGVALVLDFTHKGPKEVITWVDITQSPHADKIEPGIILLLHTGWSKHWAATGQIYWDHPYLSLDVAEQLIARGVSVIGVDCASPDRSLLEPPWDFPFHRSFLGHGGLIVENLTALGELQRPKVMVNLLPINLVGCDGAPVRGIAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAN4</accession>
    <name>A0AA38KAN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_351272</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAN4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3786594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="513" mass="55600" checksum="0CEAD35266B969ED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB78</accession>
    <name>A0AA38KB78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ADP/ATP carrier receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_308941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="597" mass="66672" checksum="D8491418C13F7FC3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBV7</accession>
    <name>A0AA38KBV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_346387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBV7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="358" mass="39613" checksum="6638285424C24EC3" modified="2024-01-24" version="1">MSSNSTGVELPPSLNLPPHLSAQKYFLVCTLTVAAWDTLVLSPRNWRLMKTGEWPVLKIIFHFLRVFMPVEFTIVAVAFFDTKWSQATCQHFFLFEPICTAILLAATSAVHVIRTHAIYDKNRPVLIGMSCLYAVQIVVTAICCGFYRSVPLDVGQGCIAGPKHNWVGIYWLAPTLLYTASFALALRRSIVSLKIKPLTTWKLMLRDGLNLYGAVWGINMANMLFWFIMKPTGIDDPIKTIITSMAAVLTTSMTLRIILNVRGSLKSGGVFTGGTASSGHSSSRTTHVISTRSGGPHSSQAAHTYNLEDMRTTKPEPEWPEPDAENKVIAIDGAQMDPNGVKITVDREVGYDQYHHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCA3</accession>
    <name>A0AA38KCA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_75684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCA3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="154"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="729" mass="82467" checksum="21DFD88AFCAAABE5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCN2</accession>
    <name>A0AA38KCN2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_403543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794835">
        <property type="protein sequence ID" value="KAJ3779471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCN2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="315" mass="34702" checksum="F3F730B42DC5C1CF" modified="2024-01-24" version="1" fragment="single">FRKFQGFRHRLFQGVSATEGHTQAMGIGKDVNIANGTTIGTTIVNETTKGIIETYPTIGKAEIGREIEGTKERTDTGATMVKLLEEPWGHPASPHNPNVGNTFDDPMYVTIEEKIAATSLLLYGPTDSLHEDCMWDSNTGACVLVGDAMRQITQNNGPVVLPPPAMDGNNPLIDTESESAVDAAEKLMDKANEPGNFNALWTARQLYWQAKRIIHLEEGLGYNSERSTLPSHLRAHLQLYGDRTVTWADKPHTQSFVGEPWDTERDPNKPHVPSLATPDLSDTVDNWALWLIVNATTKEHPGITWTQSGHVDLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCW0</accession>
    <name>A0AA38KCW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794151">
        <property type="protein sequence ID" value="KAJ3779846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="64" mass="7539" checksum="40B9366298336792" modified="2024-01-24" version="1" fragment="single">MGQLGKLSEVQQPITASKCTWISSRKQKKKKKKWINEIPTVPIYYLAKPQPRERAWQNQRGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD15</accession>
    <name>A0AA38KD15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_247142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793943">
        <property type="protein sequence ID" value="KAJ3780071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21728" checksum="F786F6F147DFD117" modified="2024-01-24" version="1" fragment="single">SGRKVVLVDTPGFDDSRDGRTDTEILRKISEFMISEYDQHRKLNGSIFFHRMSDPRFGGQSRRSLRIFRELCGAATFKNVVVLTTFWDRVNEQEGLAREEELKSNSNFFKDLVDGGARFIRHDRENNGARQVLDHIFTLVPTTVQIQKEIREEGKSLEEIAAGSAQREEINRMVAKHKKEMDDLNIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDR9</accession>
    <name>A0AA38KDR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_402979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793394">
        <property type="protein sequence ID" value="KAJ3784018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDR9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="12037" checksum="C85A9BF95B7946BA" modified="2024-01-24" version="1" fragment="single">LTQLRTGHIPLQGHLHKIKKTDSPTCPCCKQHPKTTFHYLFQCRAHRRPREILRQKVGRKNWNVGALLTEKNTLRHLFAYVDDTKRFYHILGNLPTLPEDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDX5</accession>
    <name>A0AA38KDX5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWI/SNF and RSC complexes subunit Ssr4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_365943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793533">
        <property type="protein sequence ID" value="KAJ3781691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="462" mass="48312" checksum="28D83627D5232572" modified="2024-01-24" version="1">MDNKYISTDGQTFIIFLPPHTPFPTDGIRWPEPENKFNINQGSPKELEVCEIKFGFVPGSGETMAARIRRRYRLVHSGGMGGPGAMPQLWVVHYTRGPNGPPIPAAVANQPVRMYPLRQVNEPPMFVAGEKLGQKAFPGQGMGGGMPSVAAGMGAGMPGGMVNMQPGIGGGGGGGPMGGAAGAMPGAIGGMSGNMGMPGGAGAFNQQQAQALLAQQNSNMEMLEARRTHSLGGRGGPLPPPSAPGIHGQPVPGPHGRGIPPPGAAVAGVPPGRRPAGAPGGPSLLDDDDSGDEVDSISTRTLALTRYKRNHDLMNEVFVKASFGVQPNSKPTTSPYAIFDKKELDDKIDKLSSEIEALQARAEELKHKKVERESRNNIDVQLIDGTHIPLSNSSINSQSTVKLQPQPRTDSMDSRAGTMTTVDSPSMMKLTESIADTTTESASLAQIRPVLAEGGSETSVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE49</accession>
    <name>A0AA38KE49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_388047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="17757" checksum="835166E3AFF73287" modified="2024-01-24" version="1">MHWHQPYGVCIIIILNILGLVSIALGAPVSSSLQVVTAKPFTVTVLFHGDQPVDEGIMQMARVNVQSLAYLAARQMPGTLDLTVHNWQGNPQASPKDKHVTFSIIVEGLGRQDGAYPGYYIYSEVPYNLNGMERMGRSMTAKLINPQGQTVVELRKSKGIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE66</accession>
    <name>A0AA38KE66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_276092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793494">
        <property type="protein sequence ID" value="KAJ3782171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE66"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="84" mass="9648" checksum="A3869464B5D74005" modified="2024-01-24" version="1" fragment="single">IRILDSLGELHRCGLHHGDFAERNVLINDNDIRIIDFDQPVYHDCDSKTTFEFRSGVGQRIPDVTEFGCPALWEICRSDMAIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEF1</accession>
    <name>A0AA38KEF1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Riboflavin aldehyde-forming enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_292612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793348">
        <property type="protein sequence ID" value="KAJ3785263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEF1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041380338" evidence="2">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="137" mass="14947" checksum="0537E0BFF412B5C0" modified="2024-01-24" version="1">MVSCVTFFSTLFTMILMAISSPVKTSVELDKRITHAGIGTWFEPGLGNCGNWNTVNDPIIAIPKGLYDENNGSNCGQWIHITDESTGKTVFGRTEDSCPGCASGNLDMSPDVFQQFTSLDVGVLPISWYFMPQGWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEF4</accession>
    <name>A0AA38KEF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_387595</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="MU793347">
        <property type="protein sequence ID" value="KAJ3785278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEF4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="337"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3785278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="742" mass="81932" checksum="4C33B02E92914279" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KER6</accession>
    <name>A0AA38KER6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_436172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793436">
        <property type="protein sequence ID" value="KAJ3783116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KER6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="496" mass="55023" checksum="575647540E07B416" modified="2024-01-24" version="1">MARQKAEEIISQSEKKTALGLTTPFTLSHSLKPLSNAVIRRLSTLHKLGTSNYLTSRSSLHLSLLMNPISDCRFPLPGRGESSAIKTNGQSFKCEASVDHTPEGQQSFGKLSDQEIFMLHIHDLPQQPLPHGWTQASLGDHVEYILRGRMIQIEKNSDHPSPIILATPMGTLEAAHNETQNDSPRGLTPRRNVDRIVPSFDVHHDLQEPFSGSSERYSQDASHDGYNVSRSASVNLLEPSLSLNLVSREVPLQKTVSTWGPDLLPASQFSYQSSETGFPESVSQRVATAKSQKETEEALMAPSQTKSKSARPEPYIRSGSGIPRKKPGEHEPDFVLVREPGHGDQCHWVTKIDQDQNALKICGEPFISGEGAKDHLLSHRNADNDQNDCGGSIIDAAGNRTIRCGWLGCDKPVQSKFFSRHVQGTHLGIKILCLRCGDTLKRKDEEKRHRTVRCKKNITKNKYLTPHALQESLAKYRIESPAQETSAIVILPPHMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF55</accession>
    <name>A0AA38KF55_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_434014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041416462" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="130" mass="14399" checksum="0B80E82D8CE6DCE4" modified="2024-01-24" version="1">MMLVHGPIVVILSLLLGLLSTTANAAPLDGSIALALASAKSREQQSSPHTNGINRNAPQYRVWFCPFRPVFTAPEPIKDQLFDEISRLEHLNGGDIEISLLESCPESAREFWYQKVGDNQVHYAALRART</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFJ0</accession>
    <name>A0AA38KFJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_34473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793386">
        <property type="protein sequence ID" value="KAJ3784196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFJ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="81624" checksum="830327C59AA8F198" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHS3</accession>
    <name>A0AA38KHS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidoreductase AflY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_263373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53863" checksum="B0AD884C5475DA19" modified="2024-01-24" version="1">MSPLSHRLLRNGVLNLPRASPASKPLAEALLLQDAQYHHCQFNQAGFHNHLSHHILAAYDLGAPPALLQKIYDEEARIQRPIILEEKDKEMKITEDNWTQYLGNQNAYNGFVAFFEHQVASAGVVKTLEKFIFSSSANEKGKVMLARLMSGAVHPFIQVGYGLEFGNDALVSTGLAMTAVHTSLSPELFDFENPNPSAGLSVLEILELLYKSPALQPPLPYDPDALFNARLKATVKDGKADEIRELCSKFHVDESLGNAEMMSKIEELIWTSVLLMFATGKPGRKPRLDFFLMHLVTSSLFLRSFVGVLENPTHKATIIKAFLPVMLQLVLARGRPIIKPHLLLEATDKPRPPYVSSSPYKTSERSIGSPLNDDDYNPWPALIEASLYSTDSHLLKTMRTLVLATRDYGDTPPGSVIGAFKHYSENVSKEETHPAVAKVDGSIFVRAAGMLMDYMGWTSYGQLEREDWDRSALGWDDAWKNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLY3</accession>
    <name>A0AA38KLY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793487">
        <property type="protein sequence ID" value="KAJ3782279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041206683" evidence="1">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="305" mass="34578" checksum="C632E764090EB96A" modified="2024-01-24" version="1">MSRKAFVTLLTKISYLPGVLVLAHGLKSVGSKYPLVVMVTPTLEVDARNILEKSSIEMYSIHALMPESSRHSVADHDARFRDTWTKLRAFGLKGFERVVLLDADMLIKRNMDELLEMPLAQDEIAAAHVCACNPMKLVHYPADWIPANCAHTAVEGPLGLPPAWTPTSPRPYGQLNSGTVVMNPSPALGEAIVHYLNTENLESFAFPDQDLLSAFFKGKWKPLPWYYNALKTLRVIHSQLWSDDEIRCLHYILKDKPWEARIPIVSGPFDEVHEWWWKEFDRMASELDLQSRDKVLSLVDTSKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMA5</accession>
    <name>A0AA38KMA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_396646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793450">
        <property type="protein sequence ID" value="KAJ3782849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMA5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="3"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3782849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="395" mass="42850" checksum="E53B903127B76E9E" modified="2024-01-24" version="1">MVQFAALCWCFILEGWNDGSIGPLLPVIQAYYSVGFAVVSLLFVVNCCGFVFGAGMNIWLNERLGFGKVMVLGSLFQLSTYAIQSPAPPFPAMVLSFFLAGLGMSLQNAQANGFVGSLKKNKHAKLMMLHASYGLGAFCSPLLATHFSQTRHWSFHYIISCGIAVSNTAVLCVVFRFKRQEDLLRQIGQEPNEEFPSNAPPSHNLYRQIFNIKAVHFLAIFAFIYVGVEVTIGGWIVTFIIRERDGGPSAGYISSGFFGGLTIGRLALMYVNKKVGEQKVVFIYVLLSIGLEITIWFVPSIIENAVAVSFIGALLGPLFPILVGLGARILPPYLFTGGMGWITGVGTAGSAALPFVTGMLASKYGIKSLQPFLVVMMCTLAGIWAVIPKARRTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMJ0</accession>
    <name>A0AA38KMJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_83820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="MU793487">
        <property type="protein sequence ID" value="KAJ3782280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMJ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="44"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3782280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="363" mass="39644" checksum="C26AF0080F797D86" modified="2024-01-24" version="1">MPGKTRKTPLKDADRDYLALGLEGSANKLGAGIMKHSKDGAAIVLSNIRHTYITPPGEGFQPRDTALHHREWALKVINDCLTKAGVSMHEIDCICFTKGPGMGAPLQSVALIARTLSLLFSKPLVGVNHCVGHIEMGREITGAQNPVVLYVSGGNTQVIAYSRQCYRIFGETLDIAVGNCLDRFARIINLSNDPSPGYNIEQEAKKGNRLLSLPYATKGMDISLSGILSAAEAYTLDKRFRAQGATGDEDTITPQDLCFSLQETVFAMLVEITERAMAHIGSKEVLIVGGVGSNERLQQMMGVMAQERQARVFATDERFCIDNGIMIAQAGLLSYRMGYETSLAKTTCTQRFRTDEVHVAWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNN6</accession>
    <name>A0AA38KNN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">XPG N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_300297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793618">
        <property type="protein sequence ID" value="KAJ3780981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="377" mass="42584" checksum="69A0B71B540BE8DB" modified="2024-01-24" version="1">MGVKSLWTLLTPVGRPVMLENMEGKVVAIDSSIWIYQFQATMRSKDGRALVNAHVLGFLRRICKLLFYGMKPVFVFDGGAPALKRETLNDRRKKKRGAAASLAKLAERLLSAQLRREALTHVEKPSGKDKEKALEGPVELNDDMVYLEDIDPATPSTPHKKASKAKEPNSSTKKHKFRDHDPYQLPEIDLEERVAVATRSSAPDPRLATEDELRSFIENMRPEDFDVTSPAFRELPTEVQYEIVGDLRLKSRQTSYTRLQQMLKSAPTPLDFSKQQIKNLKQRNSLTQQLLTTTDSIGKAHISIPVRIASERNREYMLIRNEGATGGWILGIRDEGTKHQPIVIDHEEVETQGNGRGNIVIDIEQDSDDEGMEEVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNZ2</accession>
    <name>A0AA38KNZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793578">
        <property type="protein sequence ID" value="KAJ3781281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="68583" checksum="DBE755825EC62F8C" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ94</accession>
    <name>A0AA38KQ94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_297070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793446">
        <property type="protein sequence ID" value="KAJ3782916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF24">
        <property type="entry name" value="LANOSTEROL 14-ALPHA DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="505" mass="55851" checksum="81F8DE3F3DC39E00" modified="2024-01-24" version="1">MPYSVGLQAASAALLSAGLPVLFTTAIIVLLVIVTVTSSLQKDVADAPARLPIYSLFAIIPFFRRRFDFLNWGFEATGHSAFQFDLLRNKVIVVSGESARQVFFTAKGLDLTEGFKILSGAIPMVRGVTSDLQTKRISLIHKRLAAVQKNEQLSMLIPPMLEDSRRLMETWGNSGSLDPFDKIYELIFQLTVRSLSCAEISDDPCVVSRLKKLYDTLDVGTTPATVLLPWLPTPAMVKKLWATKEIYDIVVTAITARQQSGVSKNDTLQMLLDSGDEKLVVVGFIMGLLIAGARATGTTACWMLTFLGGHSDWREKAKAEVEGLLASQYLSQNSPNDSLSSQLAAIPLETWETETPVLDSIIRETLRVAQPHTAMRRNLGPEMHIDGKLIPSGSYVVYPFSDVHLNPDIYHDPWKFDPNRQPETKSAYNYVGWGGGKTICLGQRLARVELKIVTALFLLGFRHSIVDGSGKFSPEPPLPNWNDILLCRPPEGSFRLRFERSGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQD2</accession>
    <name>A0AA38KQD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_354920</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="MU793342">
        <property type="protein sequence ID" value="KAJ3785430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQD2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF11">
        <property type="entry name" value="EXOPOLYGALACTURONASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041231306" description="galacturonan 1,4-alpha-galacturonidase" evidence="18">
        <location>
            <begin position="27"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3785430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="430" mass="46784" checksum="23137563935E827A" modified="2024-01-24" version="1">MFRTSSLSLLSCYVLLLLRNTHPVASWSTFVVPHTADQDDTPALTAALANFSTNSTILFQKGTTYNIFTPIKFPTLTNVEVVIEGNLTYPTNITAIQNIVASSSYPGAWFDFTGGTNITLQGSTDPNWGWIDGHGQAWWNINQQTNRPHGWAFNHITNGIIRNLKLWKPIGWNFATSGSQDIHIYDNVILAVSDNSSAFPFNTDGFSAGGSNILLESNHVENGDDCVTVGSGAINITVRNSYCANGHGLSIGSLGEGGAVADVENVLFENVVMVNCLYAARFKSWTGGNGLARNITWKNIAFSNVPFPIYVTQNYWDQEDGAKPNSTSVNNTHIEDFLFENFVGTIRDVPYVEGSCVTDPCWYAVTNATGKEVIILDLYPNTTSNILAKDIFAKTETGARVAAMCDPTTISNDVGFVCQDGPFIPTKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQR8</accession>
    <name>A0AA38KQR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ectomycorrhiza-regulated small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_350398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQR8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041390970" description="Ectomycorrhiza-regulated small secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20437" checksum="495EF2B343AC35E4" modified="2024-01-24" version="1">MLLSQSLLYTLLWLFWTSSSHAISTSQSTGGIYNVVYLDRKLNGRLVEKDAPVTDNQCPLPDSPVLLHCERFPESWAIVIGATAWRAEKAGTGRLVGIRLGNDGTFHYTPDRLVLGKVHFPKPKPDKAALFAHLDKVVPGGKFEYTKQIMEVIAKQAKSWKPDKDGFQIYEKMYQQMEVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQX7</accession>
    <name>A0AA38KQX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_291027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793323">
        <property type="protein sequence ID" value="KAJ3786105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1136"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1328"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1352"/>
            <end position="1370"/>
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    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="501"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="785"/>
            <end position="1016"/>
        </location>
    </feature>
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        <location>
            <begin position="1103"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1651"/>
        </location>
    </feature>
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        <location>
            <begin position="385"/>
            <end position="495"/>
        </location>
    </feature>
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        <location>
            <begin position="761"/>
            <end position="795"/>
        </location>
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            <begin position="385"/>
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            <begin position="397"/>
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        </location>
    </feature>
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            <begin position="441"/>
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            <begin position="483"/>
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            <begin position="761"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ3786105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1672" mass="185878" checksum="E34449E7D34550F0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRE1</accession>
    <name>A0AA38KRE1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_401636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="199"/>
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        </location>
    </feature>
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            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ3784386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="272" mass="30395" checksum="738885CF1AE4C5EC" modified="2024-01-24" version="1">MPSSIRRAFKQKMNTGVSEGSPATTTTVTRSFFRTSLRGRSSSKTSKTAATEPESPSRSRTKRTIKTSDITYIFPDETAILEDLSPQLELADRDEDDYLSRPDSPPLIIDKALVDQFPLPPVVHAYTSPDIRIPIPSSGFEPSSLLSSDEILPSPHPRVQRFMAEQKALNGLLRRQPIARSSSVTSYSRPTATAYSALFQDNGSSTSSLPPPSSGSRTHRRTDHSQSLSNRSTPHRPLLHQRSYSDMDFERHGRRTRLRAQTPVKVIYDRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRT8</accession>
    <name>A0AA38KRT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RSC complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_265633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="191"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="647" mass="72115" checksum="C68C663E10AECC00" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS45</accession>
    <name>A0AA38KS45_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_6155</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS45"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041299716" evidence="15">
        <location>
            <begin position="19"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3785301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="531" mass="60304" checksum="FAE64CC07400417F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSA2</accession>
    <name>A0AA38KSA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_333067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793339">
        <property type="protein sequence ID" value="KAJ3785541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSA2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="47"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="545" mass="59769" checksum="0051E8AE8B99C1B7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSL4</accession>
    <name>A0AA38KSL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 9">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_346992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="880" mass="97971" checksum="DC106C950C111E82" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSV2</accession>
    <name>A0AA38KSV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_397917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794221">
        <property type="protein sequence ID" value="KAJ3779787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSV2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="22928" checksum="446E184EEC0094C0" modified="2024-01-24" version="1">MFSSVKDDNFCFPIPDVLETAKLKLVPFIPALHAEAIINSTDKDTWHYIPFGPFSSAQEFIESFYEGWIRLCPEIIWFQLFVLVLPQARHTHVASHMIGLLMRYALNLPAEGGLGLRRVQWSANVKNEGSIGLARKMGMRIEGVKRWARVLKVEKAEGSNGIATRKGDPREECPGRDTVTLAICWDEWEDEGKEQVKQILAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT58</accession>
    <name>A0AA38KT58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_266938</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT58"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="35"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3786531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="387" mass="42137" checksum="FED60BD75F6729D9" modified="2024-01-24" version="1">MLSRTIIRSPGRTFSTSTAMLNRCIIYTQNGDPAQVIRAITYPKLPSPPPNTVNLKFLLSPINPADVNTIEGVYPSKPSSTSNIAASGLGSQDEPVFVGGNEGLAQVVEVGEGVKGLKKDDWVVMDRPQLGTWSTSRNVPFHGVIKLPATGLTEAHGATMTVNPTTAYNMLDGFVRLQEGDWVIQNGANSAVGQLVIQIAKDRGLSTINFVRSRDDMGPLVDHLQSLGATKILTYDDFNDKSLRGKIKDWTGGKDIRLALNCVGGEPTTAMSKLLGQDAHLVSYGAMSKKPLSLPTSLHIFKNLTSHGFWQTNWSKTHSRTQKEELIAKLADMMKENKIRAPEHTIVNISAQESDEEATAKIRDVFARLAEGKFGKKVLLKLEDTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTF0</accession>
    <name>A0AA38KTF0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793727">
        <property type="protein sequence ID" value="KAJ3780477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTF0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="20308" checksum="26BC1AA83A7CC681" modified="2024-01-24" version="1">MSTTSSPTRPARSPTPILNEEDTELQAFLAAAKREAQEKWEKLRAMRVSGVVEKALTEGEEVVGVKVNIEKDIDDVIGEEEEVVPKVEPKPRKVVTRMITGMPCGREMIPVIPVLKKRRIKPMVAESSRKKRKVVQSPVVVDSDSNSIPIPFPRPCKRCVCGDQAELFLPLEVEEDAGLIPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUH0</accession>
    <name>A0AA38KUH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_276229</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793499">
        <property type="protein sequence ID" value="KAJ3782097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUH0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF2">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="13">
        <location>
            <begin position="8"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="214"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="429"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="403"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="772"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3782097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="98868" checksum="9C51F96E6D7FAB81" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUM2</accession>
    <name>A0AA38KUM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_231315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793484">
        <property type="protein sequence ID" value="KAJ3782322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="1">
        <location>
            <begin position="169"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="355" mass="41124" checksum="54044638A632CFB7" modified="2024-01-24" version="1" fragment="single">TGGLFVISLKRVETRRKQMDLLAKALDLDFTYINATDAQSPGAYGLQRVERIIDRVRWQRNRLDEEDLEGDLVDAGNHPEPSENNPNYILDAFPFKWSQDVLDNLADPLANELGISGSDYWTLDLDRSLSSERLDEARIWEARHPMPTHWQNQTWRESQEALVNLAFVKNNLNSEKSQHLTPGGVACADSHIHAIREIIRRKLDSAIIFEDDIDIEYSIERILRHEWPFLPPTWDIVYLGHCWSSTEPFQPFLDPKATYLRKTQHALCLHAHAISLRGAYKLARFLRSPDYAYSRPIDHMIKDLVQMHYLESYTFVPALVVQTKEEESQIKVGEMNSAWKDLSGEWLVDSTKERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVF7</accession>
    <name>A0AA38KVF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_435532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVF7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="37540" checksum="AD169AF8A4C078D5" modified="2024-01-24" version="1">MPASSDKLRTFNVKYTGRNGFAERPTTSAQKREVHQHALDVIRHCGVRLPSVETIMNTDWTKPEPETSASVQKEIDDLRRRHGILLSKLYDLNASAYLDDVEDRYRSRNEVLDEDPREWMKREFRDNPQASDVDYSQDEVERMIEISNAQKELYAKTYPYPFSPTAPTPAHLPSISRHNYVYCKQLIELQRKLLRVKKEEQIKQQREQERFRQEMYNRQRREEEARRQAQIEKDRLEKKFPTTIEEFNSKPKDFQNLIARFLDAGTLQEKHLKANNWTPEEVAPLKKIYNKDVSSSSTGQIPQSYNRYGHEYAKVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWC5</accession>
    <name>A0AA38KWC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_421638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWC5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="39"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3785787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="387" mass="41711" checksum="23B94BEA18C07923" modified="2024-01-24" version="1" fragment="single">ANPELYDPRKVLDHPDFRVLNSGEKPSKESNIAAFYNPAHEIHLVEKPKPKPGPGQVLIHVRATGICGQVPYMPLSPDVHFWKHGRIGDSMIVTDECGSGHESAGEIVEVGEGVTQWKAGDRVAMEVGVPCSKPSCDACRTGRYNGCPDVVFFSTPPYHGTLTRWHVHPAQWLHRLPDNVSFEEGSLCEPLAVALAGIDRAGLRLGDPVVICGAGPIGLVSLLSARAAGAEPIVITDLFQSRLDFAKSLVPGVHTVLIDRNATPKAQAEVIKKAAGGPLQLALECTGVESSIHTAIFSVGFGAKVFIIGVGRNEQLFPFMHLSANEIDVQFQYRYANQYPKAIRLIAGGLINIKPLVTHRFTLEEAVAAFHVAADPAQGAIKVQIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYR1</accession>
    <name>A0AA38KYR1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_233609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYR1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="15726" checksum="92A928E87CAA296D" modified="2024-01-24" version="1" fragment="single">KWLHARQIMNQKAIGILVVGEAHLDTERRAEIEQVHGAYLKIYFSRLPNTANAAGIAFALNKQITNTENIQTYEVVAGHALLMEIDWHNNERLSILGIYAPNASMQDNAVFWTKVQEFFNRNPRIHKPDLMLGDCNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L078</accession>
    <name>A0AA38L078_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_309060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L078"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="146"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="37534" checksum="14167272FC89144F" modified="2024-01-24" version="1">MAPVRLRHPKGVATIQVPFDNSAYTVQDLQQQIYTASEILPSRQTLKSGYPPRSLDLVNPELPISSLGLKAGDQLIVGEESESSSRINGPKSASSPAKVNPPAKVNPQSSTSTPPRAPQQVSSARTTPSNSSSNDPVHIPTDGGVLIHRVVPDDNSCLFSSVALIFEQDIDKAQRMRQIVADGIRKDPATYNEAILGMPPSKYIDIITKSTSWGGAIELAILAAHYRTEICSVDVETGRIDQFTPGTDSSGMRCIVVYSGIHYDAATLAPMVEAPSDWHQTVFPITSSDTSDGILVAAKKLADTLRSKKAYTNTATFDLKCEVCGQGLKGEKSARAHAEQTGHTRFGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0C2</accession>
    <name>A0AA38L0C2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_393770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0C2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3787823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="147" mass="15674" checksum="84BBDE7BCA88C565" modified="2024-01-24" version="1">MAPKPASTASKAPASTASKAPAKIEASKAAKKTASKSKPTTGADGEKKKRKKSRKETYSSYIYKVLRQVHPDTGISNKAMAILNSFVNDIFERIATEASKLATYSKKSTISSREIQTSVRLILPGELAKHAISEGTKSVTKFSAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1Y3</accession>
    <name>A0AA38L1Y3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_133104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793650">
        <property type="protein sequence ID" value="KAJ3780817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1Y3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="101" mass="11072" checksum="66FE843398690B02" modified="2024-01-24" version="1">MIAPHISLQRLTTVHLVHFLGLVWWLLKKKIIRTSSSSPQVLSRHTSWICYVALSLAAVSAISVFSVSLSPQVLSQHTSWICYVALSLAAVSALSVFSDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1Y5</accession>
    <name>A0AA38L1Y5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_368448</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="MU793644">
        <property type="protein sequence ID" value="KAJ3780847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1Y5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="909"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="52"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="126"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3780847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="996" mass="105794" checksum="81120F97E6EDB081" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L240</accession>
    <name>A0AA38L240_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794870">
        <property type="protein sequence ID" value="KAJ3779455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L240"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="210" mass="23803" checksum="E1E938B1B109B3F2" modified="2024-01-24" version="1">MSSNNSRANSPSDEEEKAELLLIQKKKEEREERARREAEQRKAEEAAEAAAEARLAEIRRKKEEKKKREAEEKKKKEELEKRRAEEAKAAEAAKKMAEENRKKIEMEKRMETAALVRAQIERKEKEKLVHSPVSEASTVVVGKKRKRTVMVAVPAGDPKGDDPNPGDDGDYHDSDNEDDDPHSPSPKQSRCSRLQKSKGPVFARAGRLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L254</accession>
    <name>A0AA38L254_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_336364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793559">
        <property type="protein sequence ID" value="KAJ3781432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L254"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="330" mass="36920" checksum="087C95F17F37BF0B" modified="2024-01-24" version="1">MASPNDILPLFQAISSNQAAISSNTLTIEYIPPAAALTVLLYDCLLTFDIEVKYIWKSQWTIPKLLYLFAKYYGLAHLWYRLTGFYPDMLADLIQIGSCVLINVNLTGGGTPCIRLYALYRSSKLVLVLITSLIIAIFQYHSSLAHLGEFVAEFWGIYKSVMIQNSAPVVDFDAVEFIIPDIKRLLPGCQFQEITSINFNFTLESYIPNLFVSGDSSFASMKWFRSQDYNNSRITSSGNMLQVFIKDGTIFFFLIFSTVLMAMIIVVVQPILVAVSIPWIVGVYSFSGTKLILNLREGTDAGVESFSSTAIVGTLHRFQVHIPEVLSSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L302</accession>
    <name>A0AA38L302_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_368471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793646">
        <property type="protein sequence ID" value="KAJ3780835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L302"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="16434" checksum="215EB8D31DFF8B8F" modified="2024-01-24" version="1">MLCMLCMLWMLEMCMLWMLKMLWTHRTLSLGLSRTLDNLWYMHHRYLILSLHLILILRVLSLQTQRIHHRMNRLSLSLSLGLSTPMPSTPTPNPLDTPSTPNPLDTPTPIRTRPPHLHQRLDDLKERFVVMIYPRYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3M0</accession>
    <name>A0AA38L3M0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine incorporator/TMS membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_298853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793515">
        <property type="protein sequence ID" value="KAJ3781900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3M0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3781900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="504" mass="55323" checksum="1E043ADA50A9EF5F" modified="2024-01-24" version="1">MGLLFSIPLAGVFGTVGSSCLAGLAFCFTSTAASMFCKSCNCNSSIATRVGFAIIFCINSMLAWLMRTDFAIKQIEKWSYDYIKMDCAGDKCYGVLAVHRICFALTLFHAILSLALIGVKDTKDKRAAIQNGWWGPKILLWLVLLVISWFIPNPFFMFWGNYVTLIGATLFILLGLVLLVDFAHSWSETCLDNWENASNGSNLWQWILIGSTGLMYIFTITLTGILYGFFAGSGCTLNRFFISFNLALCIIITIMCVHPLVQEYNPRSGLAQSGMVAAYCTYLIVSAISNHAHENSTCNPLRNGSTTATGTRTTTVILGGLFTFLAIAYSTTRAATNSRALVGKRKKVGAVHLDGPDALDGHAEMGVVNTQPGRTESPRYQALLAAVEAGAIPESALHDEEDSEDDDEDVGDNRDDERSGTRYNYSWFHVIFVMAAMYVAALLTDANIVSKKPINGTTDPNSDVYIGQSEVAMWMRVVSSWICILLYTWSLIAPVIMPDRFSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4B1</accession>
    <name>A0AA38L4B1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminomethyltransferase folate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_11478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793353">
        <property type="protein sequence ID" value="KAJ3785107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4B1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="303"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="360" mass="40071" checksum="1CA10883810C01DB" modified="2024-01-24" version="1">MAPFKLPPAVRNILRRDPSVARLNSKSLLSVSGSQAPEFLHGILSSAVPTSTRPFFSAILNAQGRVLYDLFVFSDHSTNGRPAYVLEYDSHSSNTPSLHDLLKRYVLRAKVKIKDVSQEYDSWAAWGSEKDLEWDAQRDWLFAESHAIEPVWPPTEEWPWGSQEHIIRDRRAIGMGHRLLVRKGDQPPQASDHDGVPQDAYDLHRILHGVPEGHVDIVPNVAFPMDSNLDVMGAVDFRKGCYVGQELTVRTYHKGVIRKRTIPVLIQPSAHKSSEPEDIHEKFGPNIDIKPASATGGSGPQLRGSGKLLSNSHGIGLALLRTEQVEGVASGSLELNLTSESGASCSVKPWWPEWWPQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4P2</accession>
    <name>A0AA38L4P2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_42456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4P2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041305741" evidence="3">
        <location>
            <begin position="23"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="591" mass="63143" checksum="0339D387B3676D70" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L511</accession>
    <name>A0AA38L511_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Metal resistance protein YCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_310787</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="956"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1056"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="263"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="596"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="917"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1236"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3786502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1482" mass="163258" checksum="43344500203DF00E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5A6</accession>
    <name>A0AA38L5A6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_313752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5A6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="150" mass="16631" checksum="4196103E812EB24C" modified="2024-01-24" version="1">MASDQLCAEQVNEFKEAFSLFDKDGDGTITTLELGTVMRSLGQNPTDAELQDMINEVDVDGNGTIDFNEFLAMMEKKFKDTDSEEEIRQAFQVFDKDGNGTISAKELKAVMESLGEKLSDQEVDAMIVEADEDGDGSINYQEFVAMMLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L603</accession>
    <name>A0AA38L603_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_113919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L603"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="380" mass="42115" checksum="CDBC34E351D1AC6E" modified="2024-01-24" version="1">MYDAKFRLSLLERLSLIGVYIRLPFRLLVNVVLSPFLARTRGKRMNRVVAETVAGFLIANCSPRQLQYFLGPSIEKYVQWAKKNAIQPVIDNVLGSNAKVVWLTDKRTDRVLFFVHGGGYMTPFVDNMVGYCPGLRKALLKQTGGEQDFGIAALVYTIYPATFPTQLTEFTLALTQMITSGVSPENIILIGDSAGANLIIQLITHTLRPVPGIPPSPFVAIDDIDVPRRRLGGIILVSPWISLGTPAPSYAQNTKYDFLTAGPLTRWGSYYMNGVEPKHVPWVKPLSSSLYKGIELLVSRVLITAGSRECLRDDAMNLFGMIEELQIPQEKLDITLDIEEGGIHEDAILDIESPQKPGGGLSQATMRQVHWIREAFEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAY2</accession>
    <name>A0AA38NAY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase subfamily 4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_400545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794470">
        <property type="protein sequence ID" value="KAJ3779641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAY2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3779641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="22979" checksum="56358B62AC41D0CA" modified="2024-01-24" version="1">MLKIAFIHPDLGIGGAEHLVVDAALGLQNLGHQVDIYTSHHDLNHCFEETKDGVPIESTQHRSSIPARNQWEIHLRQLHLLKSLLSPGAPKYDVFFVEQLSTCITLLRVIGRTRVVFYCHFPYKLLANGEFIKDPISRAQRNMLKGGLLKRIYRYPMDWLEEITTGQADVILANSNSTGRVFKDNFQSIRRTAEVVYPVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCG5</accession>
    <name>A0AA38NCG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_359346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793395">
        <property type="protein sequence ID" value="KAJ3783991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCG5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="211" mass="23367" checksum="E01DD59797CC65AD" modified="2024-01-24" version="1">MSSPPYRPSLLPEEVLIARSDSPPPPPSTLSSPPYNAMTLPNSQPDSHYDPRGDTSSSLLLAPSTPPPLLPHYHHADNSHHRLMSLPTNIHGDYLRTPHSESRTPEGERAGDSHSGLADQHGYPFEATLSPRMHYRNFSDESLTPSTRQARNANAGENFVDNRLLIPGAVRGAGYMSSSVNTSSRDLRVERSYESFRTVFNDSQSTDNFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCQ1</accession>
    <name>A0AA38NCQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_357085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793366">
        <property type="protein sequence ID" value="KAJ3784711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCQ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56842" checksum="E58E62A352434B65" modified="2024-01-24" version="1">MEKLRSAYDAQISELRRQRDAKALEIASLKNLVSPVHQLPTEILSKIFELSCSPDADIAPEHDIIRRTFVLSKICVHWRKVAHDTPRIWSRVCLSTSQHLRAITGDVVWVGEWLSRSRGLPIELHLNFLNPYSRRQDITRGMYKLLQFALTHRHRIQILNLSGDMTCFLPIFRLPPSSLPLLKKLSLHSAFQDPYPFPYDIDIQAFLGSLELSQVELSKSGPITGFFESLILPTTQLVALQVKDTSPSFPKLPVYVDLFQHCPNLVNLIIDLQMLSGFDPTISISLPSLKFLDIVCRQLSQGVSLLHCLVVPSLQDLSLHWCGMSSPEFSRDIDRLRNHSESASRLTSLTVYIRWLYTNDDLTLLLALFPRVTSVRIYRIEFDVSAFLRAMTYSRGDPVLLPKILDLELGFKTLTDRQSYYPSELVPMILSRSWPARSHPDTEITSRQVMDLEDDVTNEVCRLQKFNLYGSWLKEPDEELIAGIPGLTFEYHPNGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NE83</accession>
    <name>A0AA38NE83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_425925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NE83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042859">
        <property type="entry name" value="NOL11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633:SF2">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="785" mass="86365" checksum="8950C50C08AF31B2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHE6</accession>
    <name>A0AA38NHE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_397818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793771">
        <property type="protein sequence ID" value="KAJ3780362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="282" mass="32389" checksum="0A2A1EC9C4996FDE" modified="2024-01-24" version="1">MLDDKDFAAELKLFLLKKSKEDCIFAKDIVDIIATSEMQEKITKGGKPVTISLRTAQRWLRKLDWHYGKKQPGMYIDDHEREDVVAYRNEFVKRWKDYERRMVVYDNDGSPTFPCGFPVTQGPRPTPEQKGEGPSIMVSSFLMPDWGLLTDEEDEAQLFFKAGKTQDGYFSGDDLLAKVEKAIDIFENKTHGMMTGLFMFDNAPSHQKRSQDALSARKMPKKPSESWTHHPNGPKMRDAQFNDGTAQSLHFSDDHPTMPGWFKGTQQIFPTLPVRNLNFKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIC4</accession>
    <name>A0AA38NIC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_229990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794854">
        <property type="protein sequence ID" value="KAJ3779463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIC4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041439778" evidence="2">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="250" mass="28829" checksum="3C22B19248BB1110" modified="2024-01-24" version="1" fragment="single">MHLILNLADLLIPLFRGSSEICDKLDKVSEWDWAILRDPDIWKSHGKDVADATPHLPGSFDRPPRNPAEKINSGYKAWEFLLYLFGLGPGLLYGLLPTRYWMNFCKLCAGIRLLYQHKITQKQLQTMHVLLIQFTVEFEILYVRRNPSRLHYMRQCIHNLRHAALEVQRIGPGITSSQWTMERCIGDLTGEIHQDSNPYANLSERCIKRAQINALKAAIPELDADRDKESRLPRGAVNLGDNYALLRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIJ6</accession>
    <name>A0AA38NIJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_272387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793396">
        <property type="protein sequence ID" value="KAJ3783977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIJ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31536" checksum="57F199B8B2629CF3" modified="2024-01-24" version="1">MPSLQIQTYSLSEGIELSFTDSGAPPDSVSYTTVFFLHGGIFNAYQFHKVHAHAHALNLRTVLLHRRDYAGSTPYSGTEIEELKEGSVVFWERLSAQLAEFLGIFIKREKIPKLTRRKSPLQDTAHILHTNFANTNGEGNGGVAIFGWSAGCSTVLSLLGAIQNPFIPDDLYKGLQEYVRSCLIYDPTYFSFGYTPPSDSRNYIPWDDPTVSKEDLPQVVAEWVSSYYDHPCYDVVGQSLPSTASIYDLDGIRSKSEQISFSSWTEEDIAKGLEGASANNEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ11</accession>
    <name>A0AA38NJ11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_370032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793959">
        <property type="protein sequence ID" value="KAJ3780049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="518" mass="58279" checksum="6967DA0A678E6DC1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJI9</accession>
    <name>A0AA38NJI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_353951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="622" mass="71661" checksum="D76134DBE2F1AC0E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJK3</accession>
    <name>A0AA38NJK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Family A1 protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_366099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793537">
        <property type="protein sequence ID" value="KAJ3781638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJK3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041217141" evidence="5">
        <location>
            <begin position="18"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="406" mass="43601" checksum="C5AD318EA89353D8" modified="2024-01-24" version="1">MICPFVVLSLLVFGVAAAPLAPSQSSSLSIPIQKHVNVTGGHNLVNAGHSRARSFRDRTVSKHNSSTKRQEVPVVNEAITYIAEIAVGSDNQTFHLLVDTGSSNTWVGANASYTYVPSSSSVWTDDIVIVDYGSGYFFGYEYYDTVTLSNDLVITNQSIGVADFQQGFTSMDGVLGIGPVDLTDGTILGSLAPVTTVPTVSDNLFNQGVISTEVIGVSFVPTTGAANEPDGELIFGDVGGSSRYTGQITYTPRETDYWGITQSISYGDTEIMASAIGVVDTGTTLNYMPTDTFNAYINTTGGIYDEVTGLYEITEEQYNALDDLIFTIGGTDFPLTPNAQIWPRDLNENIGGEAGKIYLAAVATEPVENLNFINGYVFLERYFSIFDNSNSRVGFAVTPYTNATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJQ9</accession>
    <name>A0AA38NJQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793517">
        <property type="protein sequence ID" value="KAJ3781878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJQ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="150" mass="17048" checksum="C261217AD0E944BD" modified="2024-01-24" version="1">MVVLKATPILIIIFRHAPLKIHAPNPNSLLFIFFHALLAPSYSTLLSLSLCAENAHIISLEIGIQSTKGSSYRFVRLGVNIRRSLPTAFPKNYCMRFLYMDSLLCIQWFFLVYGYHSYFVVSSVNPCRIKMYDSTIRNGSSPARCAKVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJV3</accession>
    <name>A0AA38NJV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_390134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793502">
        <property type="protein sequence ID" value="KAJ3782073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJV3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="734"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="900"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="105525" checksum="22714CE3183CFA25" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKH2</accession>
    <name>A0AA38NKH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_429204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793438">
        <property type="protein sequence ID" value="KAJ3783078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="305" mass="33695" checksum="D527CDA84BF6D718" modified="2024-01-24" version="1">MLASLPSALQTLANYRIHNTRASKEVVEKGKVLLDAKTASSLGDDAWAFLEQLTLAAIDVANYEVADECLRQLAAQFPESPRVDVLSGIRMEATQPPETALKFYDELLETDTSNAAIYKRRISVLIRIGKIEQAVTELSDYLDTFYTDVEGWVELAELYSSCNQYTSATRALSHALLLAPQNPFYVLQFAETAYTADDIPLAIKMFMLALDIIDRHASEESIPTGVSIRAWYGVKLCCRALSERSCSSASDTLLPKNLPLLDELSTERVLTAYSAAGKDNATGRELVLSWMGPSDRSGGRLHFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL01</accession>
    <name>A0AA38NL01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_359645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL01"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="134"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="235" mass="25565" checksum="CA9E43E30D2E1631" modified="2024-01-24" version="1">MSMKYLTAKLAQQIDEELMNQAGAFSIDQLMELAGLACAQALARVYDKKRYPNVLVCCGPGNQGGDGLVAARHLGMFGYTPTIFMPKPGSKDIYQRLKSQCDNMKIKTIPPSNDTSALRDALSSSNVILDAIFGFSFKGPIRSPFDSALPLLSGSRLPIVSVDIPSGWDVEEGNVEGVGLQPDVLVSLTAPKLGVRSFNGRHFLGGRFIPKTLEEKFELNLPQYPGSDQILELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLF0</accession>
    <name>A0AA38NLF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_24795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793372">
        <property type="protein sequence ID" value="KAJ3784563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLF0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="96"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="390" mass="43519" checksum="6BEB78058B2951D1" modified="2024-01-24" version="1">MSNSVFKSNTASSNWLALQKNLNRQSTRKNESIRKRRKINHYAEKSSPSSSSPSITAKALGDDSNDHKKNGESLLSLKRIVFGETEYSTEQKQPGKFIAIDCEMVGVGIDGSESSLARVTLVNYHGAVQMDEFVRQRERVVDYRTQYSGIRESDMQKAKPFDQIQKRVADLIQDRILVGHAVHNDLKVLFLSHPWNLTRDTQYLAGKSKVVRSKYVALRKLVEQELGIVIQAGEHSSLVDARATMAVYRLHRKEWDHGLNILKTSTSAKMSEAHNGDSNTVETEEKKKDEEFQNVKRKGKRKRTVDEEGVDVLNAEETQSPLRSHPKSEPLSGKQRGQPGVYPGGGRKGVSSGLSTIVRRGGSERGGQKTQWWKELGSSGSSGSKGSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM48</accession>
    <name>A0AA38NM48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_427857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM48"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="422"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="694" mass="75778" checksum="A0A272CC903010D9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMW0</accession>
    <name>A0AA38NMW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794248">
        <property type="protein sequence ID" value="KAJ3779765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="143" mass="15629" checksum="134815B2F76FD68C" modified="2024-01-24" version="1" fragment="single">DPVSPPVSPSVSSPVSPPWESRTTTSENAARLSREMDTPISLVVLKPSMSDIDSRLLDQAMQNSDLVMETSFASPTMGTNFQQKDPLDGSHDTNGRSNDPGPRTCLHALIIWTDSQLDSDGPENPELNNDRFATFWNDIANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNS6</accession>
    <name>A0AA38NNS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_344767</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNS6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="116"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="388" mass="42173" checksum="371BB5898D3DBCF4" modified="2024-01-24" version="1">MNSVSIARAGLRRAVGARFLATPSAPSTSKATFADTLNSGPSLDDFISGDVPERVVLGNPRGPRLPSYLKTSIPSGSSFNKIKKDLRGLGLHTVCEEARCPNIGDCWGGKEGATEAEGRSAATATIMLMGDTCTRGCRFCSVKTSRAPPPLDPHEPENTAEAISRWGLGYIVLTSVDRDDLADGGAHHFAETIRKIKQKAPQILVEALTGDFAGNMSHVSLVANSGLDVYAHNIETVEELTPFVRDRRATFRQSLQVLEHAKREGVRVTKTSIMLGVGETESQVLDALKELRKVDVDVVTFGQYMRPTKRHMKVDRYVEPSEFDKWKQVAEDLGFLYVASGPLVRSSYKAGEYYIENVLRGQGSEKKANKLAAQEIALGNTFAANVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ61</accession>
    <name>A0AA38NQ61_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C14, caspase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_384907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ61"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="491" mass="55297" checksum="2208A19FBDA9C852" modified="2024-01-24" version="1">MPRRSNNIPFNLTVAGQSNKKKALLIGINNTLMDQGGAGRGSRLVMPHKDVESMRALLVDHYQYSPSDIVTLIDIDDPKQLQPTRANIRTEMRKLVADARRGDHFFFHYSGHVVQTENQDHTEEDGKDECLVPCDSDGVQNLIQDDELRGILVDRLPQGSQLVAVLDSCHSGSLLDLEHYRCNRVWVPWVSKGRRKSDPIRNNVQRHNALVVYQHKRISGDRVKQRKTTVLNHPTSPLSPARRNSSREVPTAPASPVASPTVSPASTSTHRKLARALTKLEHNTSKGINAIRRSSTLRNISTAGQPIKKIQRSRTIKSQFLPWLDIKKAEAAAASSEGDWDQEGRQCESPVQEFCNGWCHHNVSPTSPTPLWSLGSPEIISLASCKDSQQAWEDSEGNSMTQRLVEILKKDPHPTMGDLMMTISHKLHDAAIKAHTQTKQYKNKVLRYRKRFPGKYELPEEGDTDGLNLNDFQDPQLSSRKPLDMGRRWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQS1</accession>
    <name>A0AA38NQS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High mobility group box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_343587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="119" mass="13468" checksum="CC0986FA3D37CC6D" modified="2024-01-24" version="1">MPKETTKAKRKTAEKAEKGSRKTKKDPKAPKRALSAYMFFSQDWRERIKAENPDAGFGEVGKLLGAKWKELDEEEKKPYIEQAARDKERAEEEKTAYDNKQKNGAASGGSGEEAEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQT6</accession>
    <name>A0AA38NQT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_343629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQT6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="734" mass="80539" checksum="05D40DB83D86032C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQY3</accession>
    <name>A0AA38NQY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_49734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="438" mass="48430" checksum="378F38CEEE5E6276" modified="2024-01-24" version="1">MQRQSPQNSLSSLSSSSVTSSSSNSPPSTNQPSAADSQKLNSSSSSTSRPSASQPSATSPQNSNSSSSSSSSPSAAAGNPPTATPTPNRKRKCPPKPGSQSYSQQIKDSAFATTKFESDWRKLIRSVFLSKTGMPNVNSFQTYSPVEDPIANAYEKCRGPGPEGMTQNLYFFGEGWKNSRWNRDVLARRVSEVVAQQENYRIPGPCLANDVILACLQDCLKQAQASWKRDKPRIHFSGERYETPEEAQARARTQEGVRSSSVRVYARKATKYKTRLDALDELLKDSTLTTFTRRKWEFARDIVHNLGKDGQSSEDTDRDDDELPLVTTVPYYRRRIVGELLQEVDREAARLQWKAATLKGKHAVVRAGKIHRRSTIQSHRSVARKLPEALYHRNLNANVRGGHVSSRVKFGNGTGSRVNAPASKGHRPPDISIHLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR38</accession>
    <name>A0AA38NR38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="11">IMP dehydrogenase</shortName>
            <shortName evidence="11">IMPD</shortName>
            <shortName evidence="11">IMPDH</shortName>
            <ecNumber evidence="11 16">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_343146</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 16">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 16">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="11 16"/>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR38"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 11 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="7 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 11 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="18">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="18">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="11">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <begin position="331"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11 13">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11 13">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11 13">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="371"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="394"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="418"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3789551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="552" mass="59043" checksum="1DF33478E5AF2899" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR87</accession>
    <name>A0AA38NR87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMN-dependent dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_402683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="110"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="490" mass="54262" checksum="CD7D72EE2361DF1D" modified="2024-01-24" version="1">MAPPWSIEEVSKHGDATSCWLIIKNEVYDVTEFLSKHPGGPSIILKYAGCDATSAYEPIHPPDAIQQYLSPSQHLGALKGADVRDLQAQERQRKRTQDEIRVEQAMKQRPPLNRILNLADMETVARKVLPHGALAFFSAGTEDELTLRENARAFERFFFHARVMRPVSKCDPSTKILGFNSSLPVFVSGASTAKLGHPLGELNITRGCGSANIIQMVCTYASIPRAVIAAAALPSQTLFFQLYKSTDLSVATKLVQDAEQLGFKAIFLTVDAIVITTRERDVRSPWVLEAHEGKTQYYVEGDTDETTNFLGTSSLHVNRNNILDADMSWKVTIPWLRSITKLPIILKGIQCVEDAVLATEMGVEGILLSNHGAFQTEISSLPPLEVLYKIRQQRPDVFNKLEGQPIKGGIRRGTDVIKAICLGAKAVGLGRPFLYALSAYGEVGVSKLINILEREIVTSMRLLGAAKISDLTPELIERVEWEPMSRQWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRK5</accession>
    <name>A0AA38NRK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_25926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023027">
        <property type="entry name" value="Mannitol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002646">
        <property type="entry name" value="PRK02318.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00974">
        <property type="entry name" value="MANNITOL_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="216"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="401" mass="44664" checksum="5C0FB5473771979C" modified="2024-01-24" version="1">MPYEAVSLPGKPIAIQFGAGNIGRGFIGAVLSQAGFHVVFADVQEKIVNALNETGRYDVHILNGETQIETIEPVSAVTSTDLKAIETIAREPLSIITTAVGPNILPRLAKPIAQIIRTRMEEGMGPINIVACENLQNATDKLREALESELNDNERVYMQDNIGFAICSVDRIVPPFSSDNILDVGVEPFFEWTVDSNSLKKTDPDVVINGMHTTNNLDAYVQRKLFTLNTGHAITAYLGFLDKKDTILDAISDDSIRTTVTQALHESGAALLAKHHPFFSQEEHEEYIKKILKRFSNHNLKDEVSRVGREPLRKLRQGDRLLGPVEMCRERNLGHDTLLLGIAAALLFHPTGLHEDQEANEMQDRIQQEGIEKVVSDLTGWEIDDHDLQKITREYSRLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS37</accession>
    <name>A0AA38NS37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_398324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS37"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="230" mass="25294" checksum="6D48D36648D99B3E" modified="2024-01-24" version="1">MPQITLFGATGPTGKAVIREALRRGYTIVVFARSPDKLDTELRFSGKIKMVQGTLDSYSAILSCLRNSTAAFILLTPSDGFPRWAGGSSSSLTVTSGYHNIIRAMLELGVKRLIGIGTPSYAEPQDGFNLGLAVTVPLLKLVAPRVFEDVVETGRLLKGLGGDTNIDWTWLRVSLLYDEPAPRNEKYKLGFTGQGGRIVLPSLSRKELSKALLDEMEERKWVRGMPFCWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS75</accession>
    <name>A0AA38NS75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_371579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS75"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="518" mass="57725" checksum="67957A5D4D3448AC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSH3</accession>
    <name>A0AA38NSH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_179620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="107" mass="12015" checksum="44F79B50908AEC67" modified="2024-01-24" version="1">MVVKEIKSYEEFKQIINGSKPVVVDFWATWCGPCRFISPVFEKLSERDEFSGVDFYKVDVDEQSDISQEVGIRAMPTFMAFQGGEKGKQLVGANPGELENVVRSCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSW7</accession>
    <name>A0AA38NSW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_159189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSW7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031459">
        <property type="entry name" value="Coa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17051">
        <property type="entry name" value="COA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="80" mass="9035" checksum="CD69131135459138" modified="2024-01-24" version="1">MFMNRALRFAQGRTFITSLFSVTFFATVLTVSASSVLPCPARPERKTFADADQNLLMRGEVVVVSRKTRKWIEEKPPGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTT0</accession>
    <name>A0AA38NTT0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM72A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_257290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTT0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36582" checksum="E3F06F2D6BEB8AF7" modified="2024-01-24" version="1">MYSSRYIHLFPPNPYQSLNPAPAPPPPPAVQQAVAHKVWIIDCRSCGSFLTNRGMKAVLLLRPNVPLFSSDALPANCSAYTSNPEALKPPVSCRPPIQPSRTCECLTQTLCCQGCGTAIGYMIVIPCIRCTSSISANNRATNGHRFVFHSSEVVGSERHYIPNEPGVMPFEPVPVAINPALHMRYSAPSREFSSLYTPSSPHEYILSPPLEAMELSPVSSLSSPAVMDEDQHLPPGLRLSGHLSPSPTSTTSGYDGSIARESDGALAGSRSSPQPPISASESLAFGMPGEQVEQPLKGGDTLFWHHLIRYGEIPAVSDDPSARKPNSAYLHRKSVLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTW2</accession>
    <name>A0AA38NTW2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_339111</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTW2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="199"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="306"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="481"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="379"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="504"/>
            <end position="508"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3790946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="551" mass="59420" checksum="493F0E52990D941C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU07</accession>
    <name>A0AA38NU07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_382798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3791118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="356" mass="39274" checksum="9EA1D41D4D3C1D3A" modified="2024-01-24" version="1">MSSPSGRRTTDRPSLPPIRDLFGTELNRLRVSDDDVPHYSDPQRQHSNVHPRTPYSHGALHPSSGFSSAPGYPPSITPHALYGREQNWSSPNSSAHSGYDPRGVAAMDHRHFARAAPAPAPNNYQYPIMRAGPPSNQYSSANPVATRDPAQNLGHRSYSNQDYPAYHRISNITENRGRSREGAQTSNQEMHNTSGDLPSSSAATPPAKYECSYCGKGFNRPSSLKIHLNSHTGEKRTPHSAFEPLPVLMYSVNLAFICPVEGCGRSFSVLSNMRRHARVHNQAAQTSDEDAVSLSHPGPSRTTVTPVNWHQYRRGSTASDVSSSESRHDRSESSDSEEEGYSHTHSAGKRVRQHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU12</accession>
    <name>A0AA38NU12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_64069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3791021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="170" mass="19519" checksum="3B8174EEE713CFE3" modified="2024-01-24" version="1">MSNVLRSYLAAVRSTLTAALTLENFSSQVVERHNKPEIEAGGSKEILLNPLIISRNENERVLIEPSINSIRLSIKIKQADEIERILCHKFTRFMMQRAESFIVLRRKPVPGYDISFLITNTHSETMLKHKIVDFIIQFMEEVDREISEMKLSLNARARIVAESYLTAIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUC1</accession>
    <name>A0AA38NUC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_430433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUC1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043708">
        <property type="entry name" value="DUF5648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18885">
        <property type="entry name" value="DUF5648"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041453087" description="DUF5648 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5648" evidence="2">
        <location>
            <begin position="35"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5648" evidence="2">
        <location>
            <begin position="216"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="33683" checksum="D0CD849ED7B24C2B" modified="2024-01-24" version="1">MTVLSCPLSSLLLTVALVLADPTSSCADTSSLITLFRAYSGNASDHFYTTNVSELDNDALLGGTYTFEGEATFLWSTSQPSTIPLFRLYNQDFVDHFYTMSSDEVLEMIDQGWAYDNTPNHTAGYVYPYSICGAAPIYRLFNPESVDHFYTMNIAESQDAMKDGYQDQGIAGFAMLPSVDGSAVKDSAGPFFLPSTMTALPESQETATSSSACADNANVVPLLRAYARNGTGQDHFYTTNSSEMNAALLTTYSFEGDAAFVWSTQEASTVPLYRLFNQNVNDHFYTIDANESNEALSSGPRVQVPPDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TY47</accession>
    <name>A0AA38TY47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TY47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="265" mass="28301" checksum="70DBB157D52AE5B5" modified="2024-01-24" version="1">MHLSVSSLRFDEERDFTLDQNEQAKNSAAPPINMTDMSVSNLTWNQNAPSAPVPMTRLRSLSRSSSPSPSLSSPSSSSAAHNALADFDFTYITSGLAFSANAMSQASYMPHSTSEEKLDFVRSGSNVHHDDGAGGVRTEGKRSLRVERGIPMGWVDDFSIPTPFNNTNTERKRARAVTVTAADGGASSTLPHTSTGTVSSSGTGRSKYGLSDMANSKDTKPQSRSPSQSRDTHSSTSPHKDLTALLDHSEINSTNGMPNVAQLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYB2</accession>
    <name>A0AA38TYB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_404175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="383" mass="43012" checksum="FCE15ACCDADE08D9" modified="2024-01-24" version="1">MTFRPRNPYYLRISKKDVLPVYLYLDDRHVDWMNDMILQHVLEDLRPKIIPKLQAESDTTSGTGPPSTKKATVDTHRGESYQFCYFLRKTQPHSVVLKTRTYAAAPPQKQELMPPPPVPAKAMKRKPKADGVSQTSRKKQKTKGKNRASHDIDSEEASSEGDVENDDASVAKPVRRSRKLTALDLDGDSLMRDVESDGEYDDDDEYIPRSRTQGNARGKTIQFSIEIEDDEEEKPKPLLHLKYQGFKILGSCLCIVVEPWPPISATSRAASVLRSTSRAPSIAPREFITANEARARSKTPLFLPDPDERDRSVTPFPDAIHVRPLPVYDIEDGDMDDADHGGMMEFSQVLNAAGDVRAGALDDDEDMEGAIFFGDADEVRELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYL9</accession>
    <name>A0AA38TYL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_304778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYL9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02110">
        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="127"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="338"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="514" mass="58750" checksum="6C7C62DA85D20785" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZB4</accession>
    <name>A0AA38TZB4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_341983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3790015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZB4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="263"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="476" mass="54315" checksum="E1F2CD4FB391A036" modified="2024-01-24" version="1">MDDDDADYMQGSDDEDYGFDYSDGDDAEESGSADVENMYYKAKSKKEDNPEGALKEFRAIVDQEKEKGDWGFKALKQSTKLLYLVLRRPNDALQTYTQLLTYTKSAVTRNYSEKTINGILDYVGGGKGGPVDVDILEKFYQVTKTALEEAKNDRLSAKTNLKLAKLWLDRKEYTRLSKLIRDLHVATGPAGDGDDQSQRGTQLLEIYALEIQMYNETRNFKKLKEIYNATNNVRSAIPHPRIMGVIKECGGKMWMGERQWNKASEDFFESFRNYDEAGSPQRIQVLKYLVLANMLMGSEVNPFDSQETKPYKSDPEIKAMTDLVDAYQRREVHSAEKILRDNGKTIMGDSFIRAYIGELLRSLRTQYLIDLIKPYSRLELSFLAKQLNVEIQEVEDLLIGLILEGKVEGRIDQVGMRLELDRKQSLEKKRYATLRKWTENLEAVHGAVVGKTGAGGRGGDPSMSMSDVYMRDSDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0L6</accession>
    <name>A0AA38U0L6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_145770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0L6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="305" mass="34706" checksum="9B2F5D6203584FA7" modified="2024-01-24" version="1">MPRKSQARTKAKVTTQRIRTSSDNESTAGYSPGADSDLTSADSSQYHEERTAFLEEEKSQMVAYLHDVLKTTITQRTVPFPLHVAFAEDVPIENRGMAPPRGPGSTVGFWEWEGERYQWGIPLSQLVEGRSKLADPNEMAFDSKELFQESVRFELVWPGYLHRRWLVSVPLHDYCGGKIRWTKKELGRFIACQYRKFAELCDHSIVCKEPAWRIGSGGIAFEDMRIVTFWNITKDIWRAEIAVDVLNNGWAGSRQEYYSLTGAEGCYSKIIPEGEDKRCPSCGTVHEPDPRLRKAEKSKRPHGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1J4</accession>
    <name>A0AA38U1J4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_338191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1J4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="816" mass="93719" checksum="903DF11B6604D0D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U6G3</accession>
    <name>A0AA38U6G3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_399386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3790020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U6G3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="73" mass="7838" checksum="71BFCA0E1A34EF75" modified="2024-01-24" version="1" fragment="single">MAKDGAFALNNFLQKKNRLDALSWVDSTAGPSHTPQWTCVCKIDGEVVATGTGSQKHVARDIAANQALKILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7T8</accession>
    <name>A0AA38K7T8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_368619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793659">
        <property type="protein sequence ID" value="KAJ3780759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7T8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="265" mass="29790" checksum="56E5C74546A84F98" modified="2024-01-24" version="1">MHRLNGVGLAALDRHTTTSRSYDLLSNSLSQNQITHLQSQLVSFRSALTTFAIKHREDILHDPAFRHRFTQMCSSIGVDPLAGPRKGGWWAELLPSVGDWQYELGVQIVDVCVSTRERNGGMIELSELVRLVRKLRGLSADQDGKGKGTINEEDIIRSVKTLSPLGAGYTIVTLNDGRKMVRSVPKELDEDQAIILALARAPGKYGRITIDELVLERERGGRGWTRERARGALDNMLLQDGLCWVDEQDNIHDRVYWVTSAMKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAM3</accession>
    <name>A0AA38KAM3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_351500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAM3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="424" mass="48448" checksum="ECC521774AD0DFD1" modified="2024-01-24" version="1">MGAVCCRPTPVDFDGDVSLFHFVLLRCVGKGAFGKVRVVQHKQTRDLYALKYINKTKCVKMKAVANVIQERRLLEEVDHPFIVNLRYAFQDDENCFFVLDLMLGGDLRFHLERLGSLQEDVVKFYIAQLSSAVEFLHQIGIMHRDIKPDNILLDERGNAHLTDFNIAVHFSERKLTGVAGSMAYMAPEILTKRGYTCHIDWWSLGVCAYELIFGRRPFRGRTNSALTTSISKDPLKWPEDAEKKCSRPGMLVIKGLLDRDPTRRLGCKPNGEGFQELQRYAWLQTIDWDTLESKEQTPPFIPDSKKANFDASHELEELLLEDNPLKAKQRKANQDNLSAEMRQMEEQFTSYDFKKMQRRSYYPHNQQLISTATVTSSGLASSRPATPATDLRPDNEIAIVNGSMELQGTDAGEMTKEVIEKEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB52</accession>
    <name>A0AA38KB52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794445">
        <property type="protein sequence ID" value="KAJ3779653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB52"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="264" mass="29364" checksum="F606FE925E24238F" modified="2024-01-24" version="1">MPDSFYKASLVTFTKRFPRHRPVFMSITAACFFMLLEGPCRLLSQVNSHIGVAACTSCAAVGCKNEAREYQDEDVPVAKAKKTHKADDMPEYPSKRMKLNSDAAICSPKPLPTEVNGNDGISVSIPSLVNPEPDAIHTEPGAIHTAAPNPSPMLDLAHILKDHPTSFQLLTFIEEYMSAVVRVCPYHQVMTGTQPGHNRLWKCSTPLLSNKKYEFKKIFTINLKAEQGSCCFNCWTPQDDIFFHDKQICRGSGRSDWEGLPCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB60</accession>
    <name>A0AA38KB60_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_433163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041298033" evidence="2">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="265" mass="29197" checksum="F47612480194C543" modified="2024-01-24" version="1">MHLRSNTFFSTLFVSLLFIASTFAIPISRDSSSVSNPSAKLVDREVVPQSVDAQADASPSSSKSPPSPTKPLEAQVTIYAKPLPEKDETALKAGIENMLSSKPITSFFRTLLVKFFKDTQPKADIRTLKKVNKIPVTAINYNTSVKPWSSETPQYQFEFILTGKPAGPDSVFSTQAGGGWNLMGEIDRASLSNGGKEPTGTLWGKEPDVRLYDKIAWVTKGKGKLRTGWTDRLECWEAEWVALKKKLGFGKNLQTLSRCPGHFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBA4</accession>
    <name>A0AA38KBA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_348376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBA4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="53107" checksum="52CAA3DF37115CD7" modified="2024-01-24" version="1">MVVILPNELHELIIDELTYSFPELKSCSLVCKAWLPRCRYHLYRVVRIGPRRVHGIEKERMSFFLRNFEVSFAHTFELPEINSCVQGLSLEYHIRDISYNPPRLTPSPTLHELPRGKAVMRPKSSFIDLPFPPLTFIRAHWKFIDMLLGYTDGMNDIRLFEQVLDRTHTLEHLVVEGFCHFHMRRDVLRSIAVHAPKLKILCLSEFRWFPSFSHLILEDIFDEWMIDFVSMNVPPLQLDRLCLRNFSSKGTNIIQLVVLPSPCLDLRALRYLAMPAKDLLTAITSERFPDLGRELIHLTITNLNMSDFRLQPKSFPKLKELQLFVKEEFPLLNFVQDFTKHWSPTSTTLNFHINFEDRELKHQGVDQSENALAGVLEEINASIVDPAIHALIRKMSKLYGNTEITYGFYVSMDFIQADGSQMQRSFMRKAFPLSFATGCLCWRERRLLEWWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDG2</accession>
    <name>A0AA38KDG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_389066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793417">
        <property type="protein sequence ID" value="KAJ3783478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="248"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="427" mass="47083" checksum="267EA5689EB31A15" modified="2024-01-24" version="1">MSQRKGFQPHHDLDTKMMNTNTTNTIKIANVSNNVRGEVVALFNTLIGDVRSTSEFRDAIGTHIEITFNSHDAAKKALCMSGYTIGGCSLLVTPVFKEDDISPKLPDNRRNLYVLGLPFDFDKGEFAAIFSRYGKVAHCVILATVDNASRRRGFVVMASHEDAKRAMMALTRTQIKGHTIDVSWSIVQRSQGFLDGGDRATVFDPHSSSGPEGSQGNDDPVLPTFDSSETVASLPQEESFVLTFTPTNSLLVTNLPFILFANTSDLEPLLFPFGSIKKLETIALPSPQETTSALVEYDALESATEAKVSLQGQCYAQYRINAEYVVFSDASPVPPVAAFSDFDDFEFKTDRNYGRNNLFSTSAPSSRSQSRNHSNVFQQKRPLQDISNSFNYLQHPFAPPPLYAPKSGPLTRSNSANSRYDPDLVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDQ3</accession>
    <name>A0AA38KDQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_428781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793399">
        <property type="protein sequence ID" value="KAJ3783898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="508" mass="57191" checksum="C3B42EF838FC3F04" modified="2024-01-24" version="1">MPFATVDILFALFACFYLYKFLFTRKYPLPPGPKGWPLIGNAFDMPKTHAWRTFAEWGKKWGPILSIQVLGTPFIIISDPEIADDLLGKTGSLYADRPTVQMALLTGWDRALSGARYNARFREYRKLIGKVIGTKGSMTKFYPVEDYQANMSLKRIFQKPENPASAIRKTAGAMVLHLTYGYKILEDQPDPFIAKAELAMEQFSDTHRTGAYIVEIFPILKYLPTWFPFAEFKRKAVECIGPCNEMADVPFAYVKEQLDKGEENNSFAADLLKDKSNSSEKLVDLKWSVASFYGAGSDTTVAVVYSYLLAAILNPEIQRKAQAEVDSVVGKDRLPSFQDRDSLPYIEALVKELYRWLPIVPLGMIAPVVHAIFILTGYYIPKNSLVFVNVWYFLHDPTVYKDPSTFNPERFLGSNPEPSPIDRGLFGYGRRVCPGAHLADVSVWINIVKVVAGIEVSPAVDEKGQVKMPVPETTDGIIVRPIPFECVVKPRSEYLLHVLEEALKDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF69</accession>
    <name>A0AA38KF69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_360272</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793410">
        <property type="protein sequence ID" value="KAJ3783641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF69"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3783641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="113" mass="13051" checksum="93B3D0FBFD025090" modified="2024-01-24" version="1">MSEAMDVDPPVKKEPKEGKVDGGKARFEVKKWNAVSLWAWDIVVENCAICRNHIMDLCIECQANQVSATSEECTAAWGICNHAFHFHCISRWLKTRNVCPLDNREWELQRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFA0</accession>
    <name>A0AA38KFA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_272828</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793405">
        <property type="protein sequence ID" value="KAJ3783761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFA0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="169"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="244"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3783761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="33336" checksum="71100877D08A930B" modified="2024-01-24" version="1">MSRVKLASIKALTFYKDELTESRRTSPIPQLVCAGKPCKTYQPEVVHCKNIGGIGLDVDWKCEADLPEALRFGKVMVSCEGWSGPGDPYVLKDSCSVEYRLVEIPKDLRGHSESYHTSGTKRKPSTRIHENDLKLKKHSAMDIVFTVAWVAVLLFIFYSFLKSCLQTRETSSTGSSRGNRPEGAPRPGGGDGRFPGYYDNNTGRDPPPPYSKTQNTEPWRPGFWTGALAGGLADRYLFRNNETGDRQRRQWDWEQSRRPTTFFGGGPGRTGSTSNSADRAEGPSNLGSVRRSTGFGGSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFX4</accession>
    <name>A0AA38KFX4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rab-type small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_293406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793361">
        <property type="protein sequence ID" value="KAJ3784871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFX4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="208" mass="23126" checksum="3E94A5389B0BFE17" modified="2024-01-24" version="1">MPPPHYDFLIKLLLIGDSGVGKSCLLLRFCDDAWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWHANIEQHASEGVNKILVGNKSDWTDKKAVTEEMGRELAEELGIKFIETSAKLNEGVEEAFFTLARDIKTRLIDSQGDAAGNSNNANDGSVQVTQRPSSATSGCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKI1</accession>
    <name>A0AA38KKI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_156085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793819">
        <property type="protein sequence ID" value="KAJ3780269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKI1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="286" mass="31111" checksum="BE8DF47DABC5F5DD" modified="2024-01-24" version="1">MPSSAPIVFITGCTVGGIGAALAQVFAERGCTVYASARSEKSMDGLQHPNIRKLLVDVTSDESVKDAVEEIYEQAGRMDVAISNAGLPGIGPLIDLPLDYTQSVMDTNFFGFVRLCNHLVPRMAKSKTKGLIVPIGSILGELGTPWTGIYNASKAALHSYAETLEMECRPLGVSVMLVAPGSIISNIANNAAKLQFHDPPSESLYKSFSSSIRFVMFQSQTKEYGAMPTRDFATQLADYIVTRNGQLVAGPVKYVSLGGSTWIYKALKWLPRQWSYDMLWNGLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKP2</accession>
    <name>A0AA38KKP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_380589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793727">
        <property type="protein sequence ID" value="KAJ3780479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKP2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="291" mass="33696" checksum="2FD8F410AB46D42D" modified="2024-01-24" version="1">MAYLEDSQVPEYRQVEVASWFLKGKAYTFFERMCGESSCDWSLKKFYEKLYDFAFPIDFRMEQRWKLVNLQQRNRRIRDHVGIFKDLCNTAGMLDKRHKVIFLWDSFEPVITRGLLQMGHTSETSRLEDLIDDTEKVELIEGVGKPTSFSFQRRDTGDPRPNSVQMGKNFAGGRFTQAPKQDKGGTPERPVASGSTSKANGLRERHSSSRPRSSNWECQPRKQLSEQQRNEYRTAGKCFECRETGHRSHDCPKNNSLKSDSRRTNGPPGFTTHNMESLQSPPSTYQLRVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKP6</accession>
    <name>A0AA38KKP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_397919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794240">
        <property type="protein sequence ID" value="KAJ3779775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="219" mass="24996" checksum="59855A4FD25BA37C" modified="2024-01-24" version="1">MELTQGEGRGSYIWGRSVHNTRIERLWVDVTVGVGDNWRQRFTELELNHGMQIDNPHHIWLLHHLFLPTINAQLQFWAESWNFHPITIGNGPNQRPEEMFGFDMLVHGSRGDSLDHHLTPDELEVFGVDWDAYEEDAILRHLRSNYANEGNSSWLGHRGPPTELSGVEVSEPPSILTAEEISLLDLTVASLSHGSTTEEVAHLWRQALIIARILRLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLE7</accession>
    <name>A0AA38KLE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_414898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793669">
        <property type="protein sequence ID" value="KAJ3780705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLE7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117197" checksum="1167BAB3EA378C9F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLQ0</accession>
    <name>A0AA38KLQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_319429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793511">
        <property type="protein sequence ID" value="KAJ3781949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLQ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="103" mass="11557" checksum="A9682BCF939F3531" modified="2024-01-24" version="1">MSQAQFEVAVDIVKNPRAGRPTMKPSQDQQLFFYKHFKQVTVGDVNTSRPGFTDFRGKAMWDAWSGVKGMSKEDARKAYVDQLKQLLESIGDTESIAEVDAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLW0</accession>
    <name>A0AA38KLW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_86268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793494">
        <property type="protein sequence ID" value="KAJ3782174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041363019" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="23346" checksum="C735D0956FDFC0FF" modified="2024-01-24" version="1">MLSKFAVCVFSVFCINLGVDFGTHVGAAVVLSATNPLLNNLATLATIPTSCNDTCNAIEATISDCTTVQCVCTSSNGNSLTTCVDCLEAVKPNQTVIQQAQDILNQYAALCDDGGVSVPVQTASGFSGSVGLPLSTASDSASQSTNAESVTATSPGLLSSGLTQTLQSTVTASSILASSLPLTTVASSVTSSGPSSTTIPSSSASKVTVDHRSFAVLGTSLVLGFFGSCLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLX7</accession>
    <name>A0AA38KLX7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl hydrolase family 71-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_436757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793489">
        <property type="protein sequence ID" value="KAJ3782249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041439482" evidence="8">
        <location>
            <begin position="22"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="486"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="608"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="747"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="856"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="711"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="951" mass="101937" checksum="0413EC03038E3829" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMJ2</accession>
    <name>A0AA38KMJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_364168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793486">
        <property type="protein sequence ID" value="KAJ3782295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="186" mass="20812" checksum="A4443D9E2D6912CE" modified="2024-01-24" version="1">MANRYIDTEPLESQLPLWLRFLDKTNSTVISITACFLLYTQSSGVAYFASGGAACIMTVKMVKKLIRQERPGNKRRKTYGMPSTHSTTSTYYATYILLAALYLPIHQSLPQTSTTRILSLLIVLPWATMITLSRLWLGHHTLAQISVGCILGFGFACLWFFIWVSGLNGYGVKAEQSWRSLSGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMN0</accession>
    <name>A0AA38KMN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_436064</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793427">
        <property type="protein sequence ID" value="KAJ3783269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="133"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="353"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="446" mass="47388" checksum="36E3084F9DB68099" modified="2024-01-24" version="1">MHSDGASRPSSKNEVSQQSVGEDAVISMRAAALDVAFGSIAGMVSEVFEYPFDLAKVRLQSQLLSPTSSDGQPRFKGPMDCLMQTWRDEGFKGLYRGLPVPLVGSMAETAAVFVAYSSLKNVIHRYYDSPNELTIPQLCLAAAGAGAATSFILTPIELVKCKLQVQMMTTPTPARIPPIHVPVTPKFLPKNPSSSSIYAPHSATAASIPVPSSSLPGPFSIARHVVATNGIRGLWLGHTGTVLRETGGTAVWFAVKEWVARGLKDRRAKADSSLLPADQYPSTLLPWESAFSGAISGAVCVAALYPADTVKSAMQTEEELREMRTYQKRASSAAREWSTSSSSVPSLSSSSPSTSPPNAFPTTTASSKVLSKPSSSIPASIIRKTSSKAAAAASIESMSFLETFLKIYRTHGMKGLYSGCGMSMARAVPSSGIVFLVYDGLTAWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNS5</accession>
    <name>A0AA38KNS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_388284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793375">
        <property type="protein sequence ID" value="KAJ3784484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNS5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18682" checksum="27A7C3B3BD1B10DB" modified="2024-01-24" version="1">MSALPPAARIAVGVGLAGSAWCAGAIMSCSILAVPALTDPNLPAAAAARASCIWHNLYNRGKSTVPPIAISTAAAFAYATYAIPNPFSLKLIQRSRNLLAVAGLFTVAIVPFTLLLMKSTNDALHAKALAVQERSRKGLYTLLDDGTRELLSNWNILNFVRGIFPLAATGFGISAVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP68</accession>
    <name>A0AA38KP68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_390545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793548">
        <property type="protein sequence ID" value="KAJ3781536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="174" mass="19600" checksum="425D16A79656E0D1" modified="2024-01-24" version="1">MSGEIFNPNPTVFRSSTKSHSPRRLLAAKKSLWINEYEPSQLVQVLDEEEEEAIDQDEIFDLIKNIYDPEHPNTLEELHVVSAPQIDIAENRVKVEFTPTVPHCGMSTLIGLSIRVRLIRSLPTRFKLDIVVKPGSHQSEHAVNKQLNDKERVAAALENPALVKTVEDCLTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPI5</accession>
    <name>A0AA38KPI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_313407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793349">
        <property type="protein sequence ID" value="KAJ3785234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPI5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041276073" evidence="3">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="274" mass="28752" checksum="6FD14E83DC95DD8A" modified="2024-01-24" version="1">MSKFSRQSLFCILFSLCAFYLVSASHDFDPLLHRRHTLNANLAKREAASFRKETSLEKRFDDCRFTYYADGLGACGQTNQPSDFIVALNSAQYNGGQYCFQMITITVGDKSTQAQIMDECPGCPYGGLDFSEGLFQYFASLDEGVLTGSWNFDSGATSTSETPASTYTPPTSTWTPAPSTSSTSTWTPTSTSTWSSSSTSLSSSYTSSFASTSTASSSSASSLLSSSSSSTATTSTASATPTVIASSGVFGMLEVAVMQMGLVAASGAGATSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPL4</accession>
    <name>A0AA38KPL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="110"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="450" mass="50530" checksum="2462331A3B78AFDB" modified="2024-01-24" version="1">MRFLNLTSDDILCCYSDSNNAIVLLPSSSHLADVPSHCSSVSLHSSTKSESIISKHESLRINLSLSLGASWQAIKVPLDCRWKIYATRSSRNLYQFSIFPKRNLASFLSQIPDKVPLYSLLLPGTHDTMAFYGWMISQCQSAETPLHVQLQNGIRVIDIRLANIEGRLIAYHGKYPEKTPFQTILSAIYAFLTSPVSCRETIVMSLKQEDYAVTPPPVFSRLVREEFAQSAGGLDILFLENRIPKLGEVRGKVVLLSRFGGDGAEWENGLEGLGIHPTTWPDSERDGFTWECKDVHVRTHDWYAIPSFLYIPEKVSLAAKFLQRPSNNDIQPTLSIVYTSAASFPFAAPKTIAQGFGWPKWGFGVEGVNSRMGKWILDVLSGSINTMEFANRDMKVEEKDGLSLRDGDCLTEPCLRGWVLVDFYDQPEHSLVDLLVECNFRGRRPGEEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPT6</accession>
    <name>A0AA38KPT6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_312509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPT6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041290849" evidence="6">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="77"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="261" mass="27524" checksum="9780DCC62F7493B4" modified="2024-01-24" version="1">MLKLILFINALVFTTLTSVKAAPTVTTPGPVPIISNAAAIAGGLITQPSSNDRLEKLLTDANGNLLTGDALRQLTVFDFNNQKPADGARGGSILLATVDNFPILQDLGISGAISFIEPCGLNIPHLHPRADEVLITIEGILDTGFVMENGFNTEIETQLGKYQGTVFPMGSIHYQQNPTCDPAVFVAALNNEDPGRSDIATSFWMLQSEVINAALGFPTTIGGENIDAWRSHLPVNLAAGVDSCLQACGLLANNSSSSSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPV3</accession>
    <name>A0AA38KPV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mnn4-regulates the mannosylphosphorylation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_356829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPV3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40606" checksum="60452B8D01758B99" modified="2024-01-24" version="1">MISILSRFTRGPTKAAYARASLIRPATMHTPTSIATLSTLSSSLNHPSANPRSLTQYQALPRSILVRTVASTVSNRPASQTFDHAAVNIREEASNSAADIAKTIAGGNIPASDHSFVAITSSLASSVPKPVLAFGLLGTVPYVGAGATTVYLASVAGAAAAGHPTSIDPGVALTMLDQALNIQVTYGAVMLSFLGALHWGMEFAKPRPVQSESIRRLLLGAAPIFFAWPTLALQPMTALLVQWVGFTGLWWADATVSGMGWTPAWYSQYRFYLSILVGTCIIGSLAGTSYYGPVAGHGFLSHDLELTREMRKNLKDEREGTVSGVVEALPADQSSGAYVMLKKRDLTKEKQEQQEKQREQAAKQEAEEIKKSQKDAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR75</accession>
    <name>A0AA38KR75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_144562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR75"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041205565" evidence="2">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="182" mass="20827" checksum="2DCC90683339F0FB" modified="2024-01-24" version="1">MRIHSLLSLVFASAIGAASAFPTLEVRSDNSDTLVARAAEPEIVELPRYSPRMKREAQRGNAPDWKREPQRGNAPDWKREAQHGTAPDWKREAQRGNAPDWKREAQRGNAPDWKREAQRGNAPDWKREAQRGNAPDWKREAQRGNAPDWKRDPQRGNAPDWKREPQHGTAPDWKREEGSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRG3</accession>
    <name>A0AA38KRG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAPP trafficking subunit Trs65-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_351229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1349" mass="141965" checksum="5087B589015E5611" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSJ7</accession>
    <name>A0AA38KSJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_375409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793329">
        <property type="protein sequence ID" value="KAJ3785871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSJ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30253" checksum="4BF6C0C683AC3B29" modified="2024-01-24" version="1">MVLRLNLQHRLIVKAFNDKLILAPVNLKPGDRVLESGAGSGIWVLEFWKEHSQKNIPLVIECIDISRDQFPSQVPSDIHFSLRSILDVPPEWSNNFTFVHQRLLVAALPRPLWHEALAQIFRVLKPGGWVEFVESHAKVRKFVVGPNSKKLSLISDRMFEEKNFVGDTEVYLPPVMREMGFVDVRCEGKDVPISQTIDDGLDRVQIWYDLWKGFKGSILAGGGYGIVSSEEEYESLLLGCKDEWNNSTEAYTTYWTIIARKPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSQ8</accession>
    <name>A0AA38KSQ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_180659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793324">
        <property type="protein sequence ID" value="KAJ3786051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="281" mass="30101" checksum="0E6DE20CFF4FBDE5" modified="2024-01-24" version="1">MERRATSPSSNSFSDTDSYEDSNSIDEVEATLNNLDDELADTEQALSTWSSQTPSTGYGSYMGSGSGTYTGNGTYTPSGTFTGTNTTTQTGQGSYTGSPSFVSLPSLFSPTAGSSSLQSSYPPPSNDPRIRLSHITERTEGTESRPVSGVSYATTVPARPRSAFLSSGAGRHSRSSTDPSDLPPPGRANQLIGLFESGSTSRSPSPTKNLLPPLDHLTRLLRSLILRARLRKARSLLPYSPLPKLVQVRVRVLQKAPNRPRRLLPPLSADQPDRKALQGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KST3</accession>
    <name>A0AA38KST3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_117088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KST3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="515" mass="58607" checksum="B28875923EC0AC6F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSZ3</accession>
    <name>A0AA38KSZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_262626</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14"/>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSZ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="18">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="158"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3788505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="369" mass="39510" checksum="76D2E6642C1D35FF" modified="2024-01-24" version="1">MSTQKSQQMLVAVVGVGLVGSEFVNQLLSIPAESSPFRLISLSSSSRTVFFEPANAILSPEKWKTILSTSNEKPDYETLTRKLSGFINPATKVAIVDNTSSDEIASFYPKWLKAGINVITPNKKAYSGDLGLYEQIVRASQESGARFLNESTVGAGLPVISTLKELVATGDKVKKIEGVFSGTMSYIFNEFSTGSPDGPSFSSVVSVAREKGYTEPHPADDLNGFDVARKLTILSRAIGSSSLPSLQSFASVQTTSLIPPALEGIPTGDEFLKRLPEFDEEFDKMRKDASKEGQVLRFVGVVDGVKGEVKAGLEKYPTSHPFATSLGGSDNIIMFHTERYSPRPLIIQGAGAGAAVTAMGVLGDLLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTU2</accession>
    <name>A0AA38KTU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_367985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793614">
        <property type="protein sequence ID" value="KAJ3781017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTU2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="173" mass="19470" checksum="BB769DA31E29DF5F" modified="2024-01-24" version="1" fragment="single">TITGAMKSSPTDLLDIHAGLLPMDLLLKKICHRAVLRLYTLPKQNPVTKIAIEAFRKQNVTKMSTPLRLLPLLFNLPPPTEVETISLPNRPGHWDIPIDIQILKKEDATEIARNAPTNYKIFSDGSGHNGMVGAAAVLYKQGELRPEATIRYLSRRRQKRRWEAIRSTAQAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU52</accession>
    <name>A0AA38KU52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_277291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793543">
        <property type="protein sequence ID" value="KAJ3781587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU52"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="16042" checksum="D4B49887093A68A1" modified="2024-01-24" version="1" fragment="single">MTNDISQIETEMEDCEAEIHWLQSHVAFLHNHSRHLDEYKTCLYSLMSPIRKLPDELTLRIFDYACGLNNLTSGQLKTMPALAISSVCSHWRNLAKASPQLWSRMRINLTVMHTDHLGFDLLQMYLDSSQQYPLSFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KU62</accession>
    <name>A0AA38KU62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_256595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793538">
        <property type="protein sequence ID" value="KAJ3781632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KU62"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="254" mass="28246" checksum="069C93B653577386" modified="2024-01-24" version="1" fragment="single">ALWIADFIETLPTEINAIWQKKTTGASVLFLINRYSLLLSLIFQTLLDLPGNQTEEQCDVTYNIVGVIQILAVATTNVLFALRVYSIYNKNRIILGTCSSLIISRLVIDILQQITFQASSSAGTQFQSFSACVLIVLDSNLYNQYVDDEKSLVPFLALVYDIYIFGLTIRKTIELGFEMKRHSQFSVAHVILQDGDLPNMLISRLMLNLRTFPPPEGHTLTTSQGAYLSSLHFASNQILGNIGAPLDGGSFNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVN1</accession>
    <name>A0AA38KVN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_271368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVN1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45080" checksum="C5EE0AE4BC6605BC" modified="2024-01-24" version="1" fragment="single">PCRFLLPLRVAEQESKARIHLLEIIQTAKRLDRILVLPHVGKSRLGLCFRWSFEAYYDEDLLKGILHEEGVRAVTQEAFKHWLDSSPSRLPRGQLVSLMSKAEPDRPGTVKFVINNGLIASVDTEVIMSQDPRLPGCFGDRFNMLLSNDFTPIAIYPSPDLSKSLKKQPIGEEFISIFGRENIRNASRSQVPFDDEPEVFMLDWDMRHPIYLQPFKESIAYSPSLEVLAQKLFSSSSPYVMIHWRMESVSPDILPDCAHDLVDTISNLLHTSVLGEGIQKVWFAGDYPVPIVNHLYPSSDRASVPTIIQKKSGTFRDFGEKHRETVDILVDAFREGAELDRWVLTDLTAELVRMEEDDGILDVHPDFLTDSGALGILDKMIGMNAAIFVGGSKRCGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW00</accession>
    <name>A0AA38KW00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_337929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794676">
        <property type="protein sequence ID" value="KAJ3779543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="2">
        <location>
            <begin position="97"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="323" mass="36524" checksum="65CA39260D7C3192" modified="2024-01-24" version="1" fragment="single">QIGLRDRPRGLTVPTHAPTFKPTQSADIENENPFILPPQSLPSRHQLKKINQMNTWTTEVIPKLVHPYLRLLRETQNLQQEGVPAITECVCLGSVHSLSVLVVRFDYLERISLSICACRSAAVQLVERGFFPCAPLQPSLAVDIRLLDFATRLFLKISPNNTAISNTLTEFLEARGYQMKGEDPLRRRFGNALQWFNSLQHATTQLVDSLIMAHCDSLDTTDGGSSDTIEDASEEGYESPKRQRFHEDPPSLSRPSEYLRSRCPICFGGNSRISEGLDSIVCIDACFTQKHTKQRYRDPQRTHPNTVFIAEEDVEAWENFVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWD2</accession>
    <name>A0AA38KWD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_353734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWD2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="259" mass="29771" checksum="AD19641611653970" modified="2024-01-24" version="1">MGVESLATSLEDVTALAHDLQAFKWYYTACCTILFYDFMLTWQEEYEYIWNGARKGHGYDFMANIQTRYIPMAFCIITLFAYFSPLWTMEMYVPVEKSVNALAGRRFLTLILWAIMVAQFVIVIYAMSQPEQNSGLPLPGIPIDQFHVCILYSKPEMDLAYLLCSIVFDSIVFITTLVITIDNKCSIWPDSGDSSTRLGQSRFRPANSALLSTIQRDGVLYFCAILSGNIIWLILTLRERIRHQAWIEIYEYAVSYIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWJ2</accession>
    <name>A0AA38KWJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_230378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="111" mass="12211" checksum="DED0F9D4ACA717AF" modified="2024-01-24" version="1" fragment="single">MNSVNSSTGLSMFQLRYGRSPRVIPPLTSLASDRKNSPGSDAGDAVALLTRLSLLEKEARDNLYCAKVLQSFHADKSRGPCEIFEVGDLVLLSTLNRRQAYKKAGERRVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWQ0</accession>
    <name>A0AA38KWQ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_427465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWQ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="75974" checksum="C3B24F6B354B6576" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX76</accession>
    <name>A0AA38KX76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_309674</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX76"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="685" mass="78268" checksum="BE17B71C9EDFD898" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXA8</accession>
    <name>A0AA38KXA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_336155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793532">
        <property type="protein sequence ID" value="KAJ3781703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXA8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="127" mass="14620" checksum="C105A7C8D79EB140" modified="2024-01-24" version="1">MYYVYSRRIGINNRYFGYTRSYADYAIIIHVYTSYFLTKFTRHVQVQLGLGVVMMQLKEKKYGIRYAWQWFSFGPAFLIGANSLANNLGSQSLANNRGSHLAPPSSLLQMFMQLNSVSPQSSNDDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXB9</accession>
    <name>A0AA38KXB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_416427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXB9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="303" mass="34870" checksum="FDE2D7C6981AAABF" modified="2024-01-24" version="1">MSIVLPPLPDPSTSPAPPASRTNKRMRPITKLSELEIQMRHSQSHLFKTNPTPPFPISLLKLKLSKRLSSIQRYNLKRDGTNQVNEIVRSAMSWGDDLYWRTSKSIVITHGFDIWLRHQGGIEPSTTAIRKQVEAFLIRIGQKHDALDYDQLNEGIIFCLTHFGHIYNRWQPNKDCDDPEEAAWRSDHLIFDDYLQAPSSANIEPPQKLKRKHEDEELVDELSQNERPAIRRRVTRQTSMSCLQENEPDAQQIGSTSLDKSSVIAIRKVSPTKKHALKDKFKQAVIEIVRARPLTRSMTRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0S1</accession>
    <name>A0AA38L0S1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_246832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0S1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="273" mass="30950" checksum="30ABFBB91C342C92" modified="2024-01-24" version="1" fragment="single">ILCDTPESFSSAIAVLQTFSLLVIDCEGLNLGTHHGSLSLLTIRPIAPQNSQNFIFDFVALTFSLQPLFSILTNPSILKILYDGRMDFSALYHTYHIDLDPVLDLQLVDICSRFARGGYSVASHRQRLLRCFSYQQIRQNKDRFKNIHILQSLGGCLEEHGCKSTSPKKHVDHETWLTRPLSSEYLEYAAHDVEIIHALYTHFIQAGYIQHPLLSLNLSQSKRYISIWNDAPPEQGNIYRSHPLLPLEIIDFIPSNTTITCQGCSRNLSSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L290</accession>
    <name>A0AA38L290_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794300">
        <property type="protein sequence ID" value="KAJ3779725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L290"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="740" mass="82218" checksum="55116B0D90E7046A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3B7</accession>
    <name>A0AA38L3B7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_396398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3B7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="119"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="35643" checksum="9A5CBAB93C99898E" modified="2024-01-24" version="1">MFVPQRLALRQREGIYDAARKVFTIVGVTSLPGSFIVNAPFGRFAPQSESLTVNGRLGWVLMELWSPLGFIYAIYHSPLSNKAAKLSMPQMILIGCFLIHYLNRGFISPARAPSRSRMHVFMPLTGLFLNTTNGGLLGSYISSPLAHQYLQPENTYASLQFYIGMFLWAVGFLGNFWADEILTDIRRKGVLRGKEGKISNGTEYYGIPNGFLYRWISFPNYLCEWVEMFGWALAAAPVPRLADVEWLLTPSGIYSMVLTTPPSKFAPTLTPPWIFLLVELCLMIPRAYKGHQWYKQKFGDAFPKERRAVIPYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3H6</accession>
    <name>A0AA38L3H6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_390452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793534">
        <property type="protein sequence ID" value="KAJ3781675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3H6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="292" mass="32955" checksum="829E2F1B7F26120C" modified="2024-01-24" version="1">MSSQPAVEISKLTFSHSPPGGRLNDTVVALRDVNLSLPRGSRTLLIGGNGAGKSTLLYILAGKRMIHQGSVNVFGKDVFKDFPPNLIYLGTEWAMNAGVRRDIVVSDFLNSVGGYRHKQRRDHLLDILDIDLDWHMHAISDGERRRVQLCMGLMGEWDLLLLDEVTVDLDVLVRDGLLNFLKEETINRGATVVYATHIFDGLNDFPTHIAHMCDGFFVLNPTPWPPSADNTELVKMGTTLHSIALRWLADDRALRIREEKEGKRSKTRGRRSNTAPDDVDRESFYKKYDYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3I9</accession>
    <name>A0AA38L3I9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_390378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793527">
        <property type="protein sequence ID" value="KAJ3781750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3I9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="5">
        <location>
            <begin position="397"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="936"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1107" mass="122235" checksum="7AFF85377A7A5A93" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L442</accession>
    <name>A0AA38L442_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_362608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793450">
        <property type="protein sequence ID" value="KAJ3782845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L442"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041458933" evidence="1">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="159" mass="16949" checksum="739CC2982ABABFF9" modified="2024-01-24" version="1">MWLSSKLLAFFASLPILISATTPRINEPANGTVITPGAAFNFSYLSIADYGTTAYNYTVWLLTSLPSSTAPSIQFASGYDLGKYAEPNYPGNPSPSNPPPAQLRMPDFSQPLGGFGDGYSLSNATFYIAVVEEYGVTNPTGPGRLLSVVMNSVLYNVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4M7</accession>
    <name>A0AA38L4M7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_375491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4M7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="574" mass="66016" checksum="710697E62503B5D2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L541</accession>
    <name>A0AA38L541_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_418836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L541"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041258878" evidence="3">
        <location>
            <begin position="22"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="578" mass="64612" checksum="866453DE942F8A7F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L676</accession>
    <name>A0AA38L676_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_165045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L676"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="258" mass="27834" checksum="C13635E75C81C73E" modified="2024-01-24" version="1">MDSKALSSKPLTLASFTNYFRPHRGEAVVRLRSNAFGLISVFISTWLLPVPSVVSAMRMLLTGNNARTEFLAGNGSEWNVRKAVCLLELTIVAMLIYNVLEAFYALQYPRKPLPPSGLSPAKKSNPLGIFSPESAKKPFRILSPNSTPTSASKFKFFSPSQSLALSESRSSQYPPSPVSSPSRVIRYSMPPKDGSSEGGVNASILSSTSTIPPTPSPSSTLASAYRGKHSSSFYGGRPMDGLFLSQITLSGDDDDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBC7</accession>
    <name>A0AA38NBC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793699">
        <property type="protein sequence ID" value="KAJ3780571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="283" mass="32938" checksum="772683A16B817D86" modified="2024-01-24" version="1">MNNNAKASSSKHRPTDDGDDERSRPRKKMDDRRKERLARLRQKVRSRKTIVRKEEEKEQRGEENDEERREKLSPIEEPPMPLASRSDFPSNHWVKPIEEELRPLPQYPEHRVSVVIPPLPSSSPPAEGPVIGALRIPRCANCKIGARRRIKCADNETLAARNARLAKGEKSSKRRGKKEEEVEEDDEEDNEMVLLPKGPRLGHRERYPRGAQSLEDRILIENRRIGEQQEMTLRVLDHMEERQERIENELARIARMLEAKENGAKEGSEDEESEERDEEDVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBV8</accession>
    <name>A0AA38NBV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_390074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793497">
        <property type="protein sequence ID" value="KAJ3782131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3782131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="512" mass="55947" checksum="7C517515209ECCF3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND78</accession>
    <name>A0AA38ND78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_332436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="304" mass="33560" checksum="14E39742CECA3DA8" modified="2024-01-24" version="1">MRMSKNSNALRTNADNRLGLIIRENAPSVGDYIANYICRRINDFDPTAEKPFVLGLPTGSSPIPTYKALIKLVKAGKLSFKHVVTFNMDEYVGLPQDHSESYHTFMFREFFSHVDIPPSQVHILNGNATDLIAECNSYEEKIKEYGGIELFLGGIGEDGHIAFNEPGSSLASRTRIKTLAYDTILANARFFNNDISAVPHMALTVGVATVLDSREIVVVVTGQRKALALSKAIEGGVNHLWTLSALQLHPWALVVADEDATAELRVKTVKYFKSIERVQDEVEATQRELKSKGKGPVPQVGSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH79</accession>
    <name>A0AA38NH79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794098">
        <property type="protein sequence ID" value="KAJ3779882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35215" checksum="AFF6048276B5C4B5" modified="2024-01-24" version="1" fragment="single">FFSMLTINADTPEFSFRLDLKCSESFPAHRFSCKGYWFHSDERYTAFPVPKDSAHLQLQLGESLGAGRTGTAYSAQVSAPLPQLSRPVPSELVVKFAKLNHCRNFAREAWIYNYLDRIPQSSGTIIPRCYGFFTTTLTELPSVKRPYNLPWSSMDGEHAKRDDDLCDNVEVKEFLDEIPSELITKERSAWNSWVPDLKNPLVAVLILEKGGPMYKEIDDQDPLVKKDIKQIIRDLLLCGVAHGDFRMSNLVRSPTTTEVCPHHKCVHKCNIIDFNRAWVLDLGVECIPDAIAAVNPGYRQPCFYGWNPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHH3</accession>
    <name>A0AA38NHH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_380358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793679">
        <property type="protein sequence ID" value="KAJ3780647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45417" checksum="E0873AB91C1D4EEF" modified="2024-01-24" version="1">MSDTHAQGVMEMKMTSFTANGQDYPTTYTRSNADPKNTEMSHALNQGEVHLNAETNCYWVYEGEWLLQGTEYAFEHPRSKQDHTRWHTWNTQLLEWKIHCTNNSPVAPHLKDFTATILSLADQIGSGSSKPDSGEWEYVQSRWNSQICHHAGVQTETSSLLILLARYPVQVVGNGTQLSLLQELGCPTIQIPFKDKMIWDEFRLSSKGMYEISNKGVIEHMWTIGDVIEHWAGKEYLVNATDPYLNILEIVPRLEQGGLMDLDVRWAPEDSPSPVILDESHRMTTSYTQPGSITLPHTDGFGYGVWVIHMKGVKVWLLWPPTKKNLAHIKRDIQGPKENNSHLSHYINHLDGMEIWLVKPGHGDLPVAFELRSSTIHAYISITVSTHSSLSTWRLEDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHU2</accession>
    <name>A0AA38NHU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793515">
        <property type="protein sequence ID" value="KAJ3781892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHU2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="109" mass="12756" checksum="CFC1D26DEDE49275" modified="2024-01-24" version="1">MNLHWETYRRYFRKSIPTTTSVSTSTQLSLRAIQSTISFHVPCHESLISSTSSRMDKVNKRASNVQKLAQENEKLKDELRAMSQRLEAAERRRQELDRKKQSMKEPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI70</accession>
    <name>A0AA38NI70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_361884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.9" evidence="2"/>
    <dbReference type="EMBL" id="MU793437">
        <property type="protein sequence ID" value="KAJ3783092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI70"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="101" mass="11297" checksum="CE60E7AABBA5655E" modified="2024-01-24" version="1">MAIKDLVESSIDENTVTIFSKSWCPYCKASKTLFEREFPDVPTKILELDEMEEGSEIQAYLAQKTGQRTVPNIFVNKQHIGGNDATQAAFKNGQLKTLISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIB7</accession>
    <name>A0AA38NIB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport protein Avl9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_50484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793414">
        <property type="protein sequence ID" value="KAJ3783542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="174"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="834"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="699"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="872" mass="95603" checksum="7CF21B23488F56A7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIZ0</accession>
    <name>A0AA38NIZ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_369190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793698">
        <property type="protein sequence ID" value="KAJ3780573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="65" mass="6844" checksum="9499D7B77C3E28C3" modified="2024-01-24" version="1">MPENSSSTSKSAANRTLAQSWAALPASTRIKFSLGICAVATAGIYLADVLEKQIPVEPREKNVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ00</accession>
    <name>A0AA38NJ00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_321503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793688">
        <property type="protein sequence ID" value="KAJ3780618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="88"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="287" mass="33414" checksum="D8AEF2C67435AC9B" modified="2024-01-24" version="1">MQEKIQEHFTKVGYTLPGIDENGNLMEEEKFWLSYECQLRYLRATKWKVDDAIKRLESTLKWRREFGLYAHMTPEHLEPEAVTGKEILFGYDVHGRPGFYMIPSRQNTTEATRQIEFAVWMLERCIDLMDEGVESLDLLINFADKAKNPSMSTSRTVLSILQNHYPERLGKALVINVPYLVNMFFKIITPFIDPVTVQKLKFNPDVVKDGIFAEDQVMKDFWGGNQDFEYVHEKYWPVLVDLCKTRKAKWVENWKQMGGTIGIRESDYKSGKSELPASTETATDSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ18</accession>
    <name>A0AA38NJ18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_414928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793672">
        <property type="protein sequence ID" value="KAJ3780693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ18"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="889" mass="99791" checksum="094DB8DBA8BFCDED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ44</accession>
    <name>A0AA38NJ44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_418310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793859">
        <property type="protein sequence ID" value="KAJ3780199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ44"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="153" mass="17443" checksum="330E844349D955BE" modified="2024-01-24" version="1" fragment="single">MIIVCSNIDAFGIDVPFFSLNIKPQYDWSYTSTVQKGLNNRTNPIMRGFILGGCSFVIGMFYTRGSADNYNRSAAVTTDDRWSWDNIQPFLELNERFEPPANRHNITGQFDPSVYSFTGVLPGFPTDIDTMVTPFDAVHELRCAFHYNEDEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJL0</accession>
    <name>A0AA38NJL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-specific peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_336725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793617">
        <property type="protein sequence ID" value="KAJ3780994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJL0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="38"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="307" mass="33891" checksum="0E66D47B05D1554E" modified="2024-01-24" version="1">MACNERVEEVPFLYNGVTYKTWVKVVGDLENNTRTPLIALHGGPGLSHDYMNPHIDLAVSSSIPVILYDQVGSARSSHFVSYRGVAPPNSPNETPPITIDLFIAELSNLINHLKIASAFDIVGHSWGGVLGVEYAIRSQPLGLRHLVLVSSLASTALWGQSVMQLSAAALPDQLRNELVQPTSMGKHREALDQLHAVHGCTCVPVPDEVKKSLDYAASEEEVCDTTVPQKMFAGEFGGWSCIGRLDRVLVPTLIINGRKDLAQDFVLQPFFDGIPRVKWVKMEKSSHMAIWEERERYMSTLAQFLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJR0</accession>
    <name>A0AA38NJR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_412527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793579">
        <property type="protein sequence ID" value="KAJ3781279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="4">
        <location>
            <begin position="51"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="322" mass="34248" checksum="18C258553EF9A0EA" modified="2024-01-24" version="1">MGTDLDGEDFTDTDPSHGTPGGSEEEDIYMAIKATCTFTAEILLAIVLPAESTYDDTAKSAGQLARPNLITALTSNSAPAIDWLTKKFGVDLSLVSMLGGRSTPRTHRGTGGAPGWAITSAPMKKLAAEEEKPEQRAKILKNAKAVKLLQDGDKVTGVEYEDGQGQKVKLEGPVVIATGGFGADFSSTGLIATHRPDLIQLPTVNGDHATGDGHVLMTSLPSHSGVLIDVDQVRFHPTGFVDPAQPDAKTKFLAAEALRGVGGLPLKKDGSRFINEMEKRDLVTAKMWEVIQSGQGPVRLVFKSGYYTASTFPTKHLVFAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKK1</accession>
    <name>A0AA38NKK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_436115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793431">
        <property type="protein sequence ID" value="KAJ3783213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKK1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="261" mass="27736" checksum="445F0AC72AA879BF" modified="2024-01-24" version="1">MSTSQINMTADRESISPSTYTDVERGWINVKECSGHGPSASTGGSSTIPIISRGHTFGRTATGNGKIANPGPAGAISFAATALLLSLFNVQAGSVEHPEVVVSMAVFTGGLSQFMAGMWEYPRGNVFNATLFSLYGSFWMSYATIFIPASGILAAYKDPLELSHAVGLYLITWTIVTAFFLFVVVRRNLALTVMLSTIFITLVILSISQYSLAGMPILSSRVQKAGGVFGIIGALLCFYIGVSELLAAEHRPIVRLPLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKV3</accession>
    <name>A0AA38NKV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_235683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793432">
        <property type="protein sequence ID" value="KAJ3783184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKV3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="117" mass="13497" checksum="B9FD508DFAA72AA5" modified="2024-01-24" version="1" fragment="single">KMARRQTIATIEQQDCKDNGDIEGYECWGFILYAVTVFGIDGMSDEEDDEENGEKVKSVLDVGFRRPEFRTLFRSVDIRHVAKGQGGRKLRRRVEVSKMVERRLPRNIPCVFLSPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKZ4</accession>
    <name>A0AA38NKZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_273634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15079" checksum="A5BC39E17BCA605E" modified="2024-01-24" version="1">MEPIDDLYGHHCQEQEQELGQETLPPYLEEPPAYSSSGSNEPITLAMYLFKFGFLFPPFWIIGALILLSPLRQPEPTPSSVWLPEKTDSEREEIIQKMRQAEVRWAKRCLVALCILVALVIVGALAVWAVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLJ0</accession>
    <name>A0AA38NLJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_358108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793381">
        <property type="protein sequence ID" value="KAJ3784309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLJ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041320941" evidence="8">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3784309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="276" mass="29974" checksum="2AA2F62B216D34F2" modified="2024-01-24" version="1">MFLSTNSNLHTLFKILTVALLSSLPSLLSAGRNRLLDDPSQSEQQRRQHSLSLNGEHAFITPGLGDVRSPCPALNTLANHGYINRSGKGISASSLISALTSVYHLSSPFAATLVAGGVLYCGNIVKGISLDALAQHNKIEHDASLVHDNALSGAKFAPTQVNLTLVDELLRTYPGGMGINELAQARMQREMSVFKEKRLNLNAFHEEIGHGEAALMWLLMKDATNVVNAKTLRQFLGKETFPSTYTIPDEEISLQKAREVSAEVGNIMKKVKTSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLT3</accession>
    <name>A0AA38NLT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793350">
        <property type="protein sequence ID" value="KAJ3785193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLT3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24631" checksum="2B7F90979210ACDE" modified="2024-01-24" version="1">MSTEIIQDPLHLPPLPRSASHPKPKGILKNAAPPPGVGQQNLRWDEANIQSTEFPEGTFTKITEPKTPYVRYNAETDEVEGEIPNLDLNGRYVPTSPTLSSSPTGANTSGPSSRRTSFSSAGRPGSARSGSAQSSRSTSFNLGDEARSDIRAAGNGKTGEEVEFGEEMDEETAQKHAEFVRARGRHYSNEAEAMKRAARLMTEEDDEMPDRDDDHDHQELENHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLW4</accession>
    <name>A0AA38NLW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal enoyl-CoA-hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_427982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="32766" checksum="19496773C33DC9FA" modified="2024-01-24" version="1">MAIVDYGALKLEAIIAILDGAVLVITLNRAKQRNSYGGTLPTELIRTFDLADKDDRVRVIVVTAESDAPAYCSGADISKGWGGLFKPEDEVEGETAHRDTGGQVAMAIYNCRKITIAAVNGHAAGVGMTAMQLPFDLRFVWEGAKLVFPFVRRGINTEATSSYLLPRLVGYSRANSLLLTGATFSPTSPLISSLYHEIIPRREDVFPAALALAKDLASNASQISVAYTKGLLQHPGDTIEENHILDSRALKLTGSGADAAEGALAFKERRPPKFPDMLSKISSPWYPWWKIVDVRHRKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLY6</accession>
    <name>A0AA38NLY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793338">
        <property type="protein sequence ID" value="KAJ3785568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041399001" evidence="1">
        <location>
            <begin position="23"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="725" mass="81347" checksum="C88198201692B2A2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM38</accession>
    <name>A0AA38NM38_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_353511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793329">
        <property type="protein sequence ID" value="KAJ3785898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM38"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119694" checksum="EDEB772F1E040F57" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM56</accession>
    <name>A0AA38NM56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Misato segment II tubulin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_354198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM56"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="6">
        <location>
            <begin position="125"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3785674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="509" mass="57420" checksum="C24805759A29D0AD" modified="2024-01-24" version="1">MREILYVQAGNLANYIGTHFWNTQESYFAYSDDEEILLNHDVSFRDGETLKGEPTYCPRLLSFDHKANFGTLSRTNTLYENEDIDGSQLWQGNIAEYGRVPIEPHAYQAHLQTDGEPTSLAADLTNDIRYWSDFNRVFYIPRTVQMLPNVPDWQKTEGNWAFGQESFQRYNEETELMESSVRLFIEECNSFQGLQLMSDTSTFGSFSISFLMAFNDELSRAPCLSFPLLGDAVPRNVNLENTVQIRKVVNDAVYLRELDSLSSLTIPILNPNTWSKGGWDVNLKIGGDPYYTSSVLSAHIESSTLPLRLKNNMEDISSFSGHLNLHGSHRFSQLAGVFPVAAGATPQDFWKQSYNFSVSQNSLMAATIYTRRDVTRGLPASTLQAYNSWSFQEALKEPYVLSTHTQAYPLPSSFPDIFCDEEILTNYMRTPHADRSSVLPSATLFSSLSTSSSTAEMFSEYATYLQACVDRRKTGILPGLVETSDDIKELVNDLWTIHDGYSGSVSDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMI8</accession>
    <name>A0AA38NMI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_157188</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMI8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="254"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3786948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="448" mass="51012" checksum="5FEFEBCE1BD34449" modified="2024-01-24" version="1">MSVLLETSLGDLVIDLETDLCPKICENFLKLCKVYYYNLNAFFNVQKDFLAQTGDPTATGTGGECIWSYINNSSQKTDSVPRFFTPEILPKLKHQIKGTVSMAVAPASENGTLTGCGSQFFVTLADNTDYLDGVHAVFGHVVEGLETLDKLNDVFVGKDFRPMKDVRIRHVVILDDPFPDPPGLEPLIPSNPPTKPPDAGSNSFFGIGEDEDPLSTLPEEEEERLRREAAARSSTLTLEMVGDLPFANVRPPENVLFVCKLNPVTRDEDLELIFSRFGTIMSCQVIRDKKTGDSLQYAFIEFDKREDAEQAYFKMQNVLVDDRRIWVDFSQSVAKANTFWSNDIQRGPGNSKKRGLGSGFGGREDLVRTRRYRDEDHDHDRHDGRGGGYGMVFELPSGESRRKERDRDSRKRSRSPDRQHRRSASPRQSDRRDRNRDRDYERRRDRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMR4</accession>
    <name>A0AA38NMR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_402271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794679">
        <property type="protein sequence ID" value="KAJ3779540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="83" mass="9154" checksum="C1351EE1656BDB06" modified="2024-01-24" version="1">MKLLASFLKREHNFGPTVFNEALYAMYHLPLLLGYGSNSNIHSSGLSSERRQSSNVGAAPGVWDVGIALAMYYHSRPRRGEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNB1</accession>
    <name>A0AA38NNB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_415984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793726">
        <property type="protein sequence ID" value="KAJ3780485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNB1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="467" mass="52883" checksum="38AA9BFAB9622E25" modified="2024-01-24" version="1">MSDGFLPRLRRGQPYDASFDRPDRVRRTHANPEIIATLKRLPVLSRLQRNKEILDSNAQRRLHHIRDPTAQISDVESIISIETSELDIIRSDSITFDLYKPFMDPLTIAELKRRNEEDWKKECEDRRRVSGESNQDNNGNPTVSTITRPQTFTLEPDITLIRQDPTQPAPLFFPTVLKLTAKHTKFIPLNFFTDKNLSFINTQINDIKITHEVDKPYILLIPDITSRIQASALAGPASESSMSYVKWLNASDNFIEFEASRFDRGHESSRVKFLSQHFTFFSQQNDAEELFQFWRPTEEHLRRNHVELNTDFDGLLYAMKWTEHITRIILKEAVEEAVEFAGYTLTNTIHRIPFDLATGTTLPLPVASDAAKRGTLSKTTSNTGNSGQATMGTNSFPLAAVKSAFPSTYSVTAATVVAPRNTFVRYAEGPTGLENSTVTANVPPINPFTSIAPDPLLFHDFSDKLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNG0</accession>
    <name>A0AA38NNG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_113846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNG0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="40367" checksum="4C9F6607F289C9CE" modified="2024-01-24" version="1">MAFPVELYQPVVGYVRDRVTLRNLLLASRCLNVEAEWSLYFKFEHVHNAQTQVLFLQRVIDCPRVARYVNSYRFEIDWRTNLDSDHIFWKLLPQALHAMGNLKILQFRTHGGMPINGLLDGCTFQLEYCHWHCHSDEMQMQAFLQTQRKLKSLSLGGWDTSFSAPSNHSEQPDLREVTGCYGVIHAFLPGRDITHVRWVPDLDDPWDVNTGLDAAGLAPAFQKLKFLKLGGYFMRPHLCSISEHLTSLVFLELMGYDKMEDVSIFALPSLKILRISIRWGLNKMAIADPQTRTEEIFAGSKSLKFIEIEEESTYRDYNRIQQYSRWKRGESLVDRYHVTDETWPSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNJ4</accession>
    <name>A0AA38NNJ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_413914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793637">
        <property type="protein sequence ID" value="KAJ3780875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNJ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="402" mass="43587" checksum="B9E2D9A05E90C846" modified="2024-01-24" version="1">MLTEGTTYDATLTNTYPNGHGQVIKRTTNSTVGFDPSSQYVSTTGTHAFVPPGPNDLRGPCPGLNAMANHGYIPHSGIATIDEFIQGTYEVFGMGNDLGSFLAIYGTALDGDIPSLSFSIGTGGNSILGTVLHPDGLTGSHNNYEADVSPTRGDLYEYGNNYEVQMTQFLQLYDLQSNVSDPSQVNYDIDVLTAFRLSRFQQSIDNNQYFFNGPITGLLVQPAAYQFIFHFMANKSEEYPEGRLDREVLKSFFSITGPDNNLAYTPGQERIPDNWYKRAIGDEYGIVSFLSETTSIGTAYPEFLSVGGNTGEVDTFTGVDFADLTGGVFNATTLLEGNNLGCFLLQGVVLALPTGVAGLVGVLDQLEGTVNPLLKEWNCPQLEEINQSLLENYPGFSRPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNS2</accession>
    <name>A0AA38NNS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793573">
        <property type="protein sequence ID" value="KAJ3781325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNS2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="66448" checksum="A98D83075F1F7A53" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNY6</accession>
    <name>A0AA38NNY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_364671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793500">
        <property type="protein sequence ID" value="KAJ3782090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="386" mass="44708" checksum="26B44E12945533D3" modified="2024-01-24" version="1">MVNNHSHVEEVIGPLRQGPRRLDLYALSESEEWWAGHFGYLKERGYMMRPRYRPGWKPSYGHDPRGIYKNMFAEDGQHSIHSAIMDALRISDSLVVAMKRVEISTGEDQIATLFSDDAHNSDPRNHSVRIIEVLPVPEGNEKILVMAWMREVMDPRFRTVGEAVQFLKEMIEGLQYMHQNNVAHRDCSMNNMAMEANAMYTRQYHPVRPKKRYDWSGRALHHSRTRCPPRYYLIDFGQSRMYDPSQPRGTEYALRSGGYTPPEGLADTPCDPFATDVFLLGNLMRTTFLDGDTWMEEPGISGFEFLRPLVKDMVVDDPSKRPTMDEVMPRFSAIIDKVPWWKLRARAAKKDEFLLVKPFRAVYHVFWTASMMLLLKPAIPSPKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP19</accession>
    <name>A0AA38NP19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_77066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793466">
        <property type="protein sequence ID" value="KAJ3782585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="241" mass="25682" checksum="F66970E70451FEFA" modified="2024-01-24" version="1">MGPLAVEGENHPENPDMSPPNDTSKAVDSSGEPASPPKTAKGPSHHHHHRPHRESTSNANPGKDSEVTLKPPRQRGSTVTGTENPKPNMQRVNSGNSDYAVTISSEHSGTPGTKNDAPSPPHTHRHGHHRGPSVSSQQSNRESMDTSKLGRTASGASRGRGRPSSMHSQRPVDKSKSRVDEREREREKDRVEQRFSALYAQQSAQTAQTGAAQAANAANVYAVTGNPAAINPGMTKPPGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPH6</accession>
    <name>A0AA38NPH6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine hydrolase FSH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_313946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793358">
        <property type="protein sequence ID" value="KAJ3784940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPH6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="257" mass="27959" checksum="0CD65B06683899FD" modified="2024-01-24" version="1">MSSPQKRVLCLHGYSQNANMFSKKLAALRQQLPEVELVFIDAPHVLQPVDLPAPSQMGYFSGFDSEPPPKDPQRGWWKTQNVQNIAAGLEVTLTLLRDVLKEQGVFNGVLGFSQGAVLAALLSGLLEKPAMYPSFLEDGKAVHPPFEFCISFAGYKPLDPLGAKLLTPNFKTPTLHVIGHNDIIVTPERAQSLIDASLNGRVEFHDGGHFVPSKTAWRKFLAEYIRNPSGDVPGPNGKAPATNGSTLVSEPVTPILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPL5</accession>
    <name>A0AA38NPL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_333052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU793339">
        <property type="protein sequence ID" value="KAJ3785525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPL5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF330">
        <property type="entry name" value="SNF1-ACTIVATING KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="65"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="582"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="736"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="853"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1226"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="877"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="934"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="964"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1247" mass="135942" checksum="B0C0F326BF23ED26" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPS2</accession>
    <name>A0AA38NPS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_267264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPS2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="48"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="280"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="631" mass="71946" checksum="92AB843003B82077" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQB9</accession>
    <name>A0AA38NQB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_71233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQB9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="206" mass="23215" checksum="F9515646BA4BF079" modified="2024-01-24" version="1">MRINLSIYLFSIVCAVSYYAVYAAPLTTSTSVNPRTHSPSTPSLSLTPSTRFASHTSLTKTTRTITVSIEFKKPHARLLHPLDENPYTPPTLGKPHQPPELTLSERIQKLIEPYVQDRMCNSHVVVELKYNNAFQSNGDRKDKRIGMYFWGVGGDCVYEDLTGKSKRCEAHLDDRKSYDVLGGYILERTGAKWAQQVEGKPSCLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQS3</accession>
    <name>A0AA38NQS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_431747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="548" mass="62280" checksum="838154E15A8773B3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQV5</accession>
    <name>A0AA38NQV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_343294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQV5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="585" mass="63696" checksum="29A042FFDE633E72" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRJ1</accession>
    <name>A0AA38NRJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_26332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="373" mass="41220" checksum="0956DA9780028893" modified="2024-01-24" version="1">MFRTGSPYSQFFMSGLLPSAAASANNANNEGQDGFLYEVDFRRRGSLPDTSSTTNVAQFHKERSFLSLDLAGAGSLRAPSLHTLRSRPSLQNLPSQKPMPKYADALPALPALNATSRASTLLPASHTNSVAGPSKLLVTSNITRNTSIKTTVSTVSTNYRRTKRSDALARLEGRSQAALASFKFGSIKEENISNFMSLSDDEDSSEDEWDMHSDEEADFVDLDIDFSSTHRHSYSTPLQHDDDEEDILPLSPSRSHAYSRSFSYSTSSAPSRMQRHRSKARSKSSYGYPSSTKSEPKVRSKTMSMFPSNAPPKEYTSFMDLEHSTHRGTSSSSSRRLSWSSPKDVTSPLPSPSLRKTDEWLQWSSFIEISAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRQ4</accession>
    <name>A0AA38NRQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_259634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="130"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="575"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="881"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="796"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="887"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117475" checksum="748CC50D6CFD650C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT64</accession>
    <name>A0AA38NT64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_383151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT64"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="74550" checksum="8117309CB1911740" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT94</accession>
    <name>A0AA38NT94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_391927</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="239"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="313"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="403"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="707"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3790669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="740" mass="80182" checksum="F61602A232AE22AD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTA9</accession>
    <name>A0AA38NTA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_129166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTA9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="23783" checksum="C1037A4054E77CC3" modified="2024-01-24" version="1">MRKISYVITFLAVVVSLIFNVLSLKRVDWLVVKTPEVLHTQITVRYGLTTLCELKHVNIPGSDNNSRLEYTSYDCRPFPKRVQDGCEEENSGFCAAWTSAGYAVEISIGFAVLALFAILIGVSTGSRRRRIWKAVAGLVALHAVMQIVAFAIVTDTMRTGAFPTFEDAKPGTGYIFNTFAWIFSVLVAAGVVLTGVSADKGHKWAAGNRAYRRIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTK0</accession>
    <name>A0AA38NTK0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_131597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTK0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="141"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="415" mass="46344" checksum="21EAB9050CD11A7D" modified="2024-01-24" version="1">MPLSLRNQPFRALYLTFDFVGTVLVRAPLWLLLSIPKSWRPRASWSIKDSFLIQLLRHFISVRSRTCLYKAESNYPIHEEKGVHCVWVDPVPKLIVGDLAIWSRAASVSSKPVRGYWYCKNTSATPNALRMASSGEKILYSLHGGAYTSGTAHPSGTNAKLVRDIMHLDSRINRTFAIEYRLSSDASNPFPAALIDALAGYHYLVHSIGFNPLDIVIEGSASGGNLALALTRYLIDYYGHSDVPELPDVPESLILLSPWVDILANDETHIEPTTRSWLVSDYMFGPRCPMTNYSKQVFLGPHGIDVAALNEYISPSSRHPLIELDFEDFPRTFISSGAAENLLPQIRLLRDRMVRDLGYDTRGAEKSLRGKVTYHEAAEASHNCLALPFAIQQDARRGLLAAIGEWLVDCTTQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTP6</accession>
    <name>A0AA38NTP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_257581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="214"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="484" mass="53853" checksum="534D71C66209345C" modified="2024-01-24" version="1">MSASDAKLVANGTPAINVPEPTRSLTQPSNGLHGSPYPNTSSNEPSSLPSLSPQPSPKPLPAPIDIPAAQTILSNGATTFSPGSTTASSVQADMKSKSLDVDDMIQRLLDVGYTGKVSKSLCLKNTEITSICLAARDVFLSQPTLVELSPPVKIVGDVHGQYSDLIRLFEMCGFPPAANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKTWKTFIDVFNCLPIAAIVASKIFCVHGGLSPSLHSMEDIKRIQRPTDVPDYGLLNDLLWSDPSDTALDWEENERGVSYCFGKGIINEFLVRYDMDLICRAHMVVEDGYEFWNDRTLVTVFSAPNYCGEFDNYGACMSVSEDLLCAFELLKPLDGAALRKEMTKAKRKRYLPWLSTNALFSPLCQYNEHCYITRDATYLWGLYTDIATRSSIFLWSKQLRSYVGTLYIHGIGAVQFSALSITVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTW3</accession>
    <name>A0AA38NTW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_391611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTW3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041269719" evidence="1">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="2">
        <location>
            <begin position="50"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="224" mass="23856" checksum="1333B9504D6754F0" modified="2024-01-24" version="1">MALPAIHSFFKLSVLTFFILAPAARASEWIEYSSNGFATLTHYSLPLNYIASCGCTAESTHYPTAALSQMAFGSSTAYGPACGRCFNLTLLNTFLSVPPFYPSEQKSIVVKVTDLCPLSTTGWCNATTNGPNAAGNYLNFDLAYPSTSIPSNFFPSNASYYGYTDFGVWNISYESVSCNGWEGWNDAAALGSVTGQGPESVCCAADPTNSSNTCTSYSDHNGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TXW2</accession>
    <name>A0AA38TXW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_305567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TXW2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="693" mass="74781" checksum="97C52E8E1CC791D2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U071</accession>
    <name>A0AA38U071_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_329231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U071"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="269" mass="30543" checksum="901A62E922B52F63" modified="2024-01-24" version="1">MSSTISSSALSLPIEIYEQILTSFWNQPQSTHDRAIFMKSSLAVSQNWAMIYMRIFSQDVYIPSGEFALKFLEILRDESPVYHSLNENGSLLNRRCRSITFQRDNDGVIVKKPIAPDSCRPTSVLVQGMLNTPTPEHPMGLAIYAVTRFLYSSNKLPELRRISILFANSTMNDLFTRNNFIGFPTQVTELDIQFTYDARTPSDVLRKIRRDASAIGLLPYSIKGVRTLRVAGLSNVAVRELVSSCAICEVVHTDWKTYRFGSERKTRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U2A5</accession>
    <name>A0AA38U2A5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_339476</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U2A5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041381071" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="28"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3790768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="292" mass="31752" checksum="F06F406A4D004EF7" modified="2024-01-24" version="1">MILRHLSKLPPSILLLLLLCHVPTIEAADSFNCIVNIDTTKFDLTSLNNEHKVTQSRSTPPSTMVDSLTFNICDDLTVQGDVAEIDRCPSETRACLTKINQKQDQEDRIVAVIPVAESNALNASFSKLSSPSGLSIVMHGQSYPAGSDNSKDQSFKLNLICNKNADDPEFVSYDGSQVEVQWRNPAACGSEAGDDNGSGDDSDSGNGSDSEDKESVGSGIGWFFLVILLAFVAYFVLGAYHKYTTYGATGMDLIPHRDFWQEVPYMLGDVVSHLCSSARPRRSSNRGGYIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U8N3</accession>
    <name>A0AA38U8N3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_338339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U8N3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="240"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3791265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="507" mass="56091" checksum="0DBD2C3B54D3FCE9" modified="2024-01-24" version="1">MNILGKGGNGCAAFHREKFLPFGPPSGGNGGRGGDVYILPTPELTTLTSVAKRVRGENGGNGQGTWQNGKNGAPLVIRVPLGTIVREIPRGDPRRTKDEWEAEAEALEGLEPAEKQAKMRDNRWVHYPRYSESNVERDAFKEAEQLLFKQERDRRYARRKREIEHPIYMDLDKEVEVEEDPNLPLGLPRKDALGHLVASGGQGGLGNPHFLSQDNRSPKFATRGHEGERITLSLELKLLADIGFVGIPNAGKSTLLRALTGGRAQTEVAGYAFTTLNPVIGVVRVAADGSFEGGLSEGMVHEETLIEEAQKQTKMEEGAFADALTRNQQAHSDAVTRGFGAGHRFDIIEHFRFTIADNPGLISKASENVGLGHSFLRSMERSLALVYVVDFSSPAPWDEIAILRDELEQYLPGMSNKARMVIANKADLLAADSDTASIEDAKVKLKRLEEYVEKKLTVEDEYGNQRSLDIVPISAKYSQNLKKVVGLMQRYVVEAREESKREREHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7B5</accession>
    <name>A0AA38K7B5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794640">
        <property type="protein sequence ID" value="KAJ3779559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7B5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="164" mass="18185" checksum="5D6FDAF219F51679" modified="2024-01-24" version="1">MYNPEFTASSLFVCDGTDPTSGPFCQDATMGIVFVAIVTVFLLGVVVIIMALIEGVCFIAAQAYTYLAKYNLCNRGNMLKRREQAVVLRELAVNRQERTLQMDVEIKVCERLTQILRRSSASAQERAYELEIEKDLLSEIAGCGGDISGEGSLIHRMPKIANRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA82</accession>
    <name>A0AA38KA82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_192395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA82"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="514" mass="56625" checksum="52030C01833762F6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB86</accession>
    <name>A0AA38KB86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_433084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB86"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="191"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="38977" checksum="58A1F9469279048A" modified="2024-01-24" version="1">MTCNLVFAPLHSTMGALLIGVLISGALWGISAIQTYFYFSVWESSALPLSLLRPSSSKTFRHQDTLQLKLLVVFISILDTAHQIMLSHSIYMYLVSGFGDVKYLGVVTWSMITMVLLSALIAVTIQLFMCWRIWILSKNNVYWIVPIVAIVLASFAITIVYFEKCWSLRTWSELESLSKISRAVNGLNFGGDIAISFAMVYLLRNFKPGIESTDALINRLMGFCLKTGLLTTVCAILSLISISVWPNTFIYITFYCVLARLYTNSFLSTLNAREQLRKFSRPAGSSLPSNNDIQWARDLGISSDHTETLDYSNSGTNPISIKQKVETYVHSDIEMNSHGKDNVFTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBX6</accession>
    <name>A0AA38KBX6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Chitin synthase</fullName>
            <ecNumber evidence="2 13">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_346222</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 13"/>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBX6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="859"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="15">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3788439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="895" mass="100978" checksum="DDC294CE676A073C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC24</accession>
    <name>A0AA38KC24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_124925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MU793618">
        <property type="protein sequence ID" value="KAJ3780988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="267"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="398" mass="45430" checksum="DF1C48943BD217F5" modified="2024-01-24" version="1">MNKGGARRYENNRTYAHPLPLSFSDSSSNRTRSILGLLGLSRSQVNNPHCEGYYDASTRSVWVVTQRDSEILWRRGFFGKGNLSRSEPSWFVRQIQDRQSRKVSSNTSKMTSEEIREKRRVERKQFKLDRAAAIAKVAAEAETIFETEGRVVVPALFGPEIPSGATWKPKAAEIEPSLDPELSNAECETAVENGEGGEEPLEDMEHLQLTLSEAFFLAWNLDCLTILDPETDEPLSLPDIWNTFQHAHLAFPMPSFPASELQFDNPFLVHYAVYHHYRSLGWVVKNGLKFCVDYLLYKRGPVFTHAEFAIVVCPVYEDPQDQEISNTDLHNASPFTWSWLSTINRANSQVMKTLILAYVTIPARQRLSRQTLNSPACFAHYSVREVIVRRFIPARMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCS0</accession>
    <name>A0AA38KCS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_364011</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU793480">
        <property type="protein sequence ID" value="KAJ3782368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCS0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="84"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="283"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
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        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3782368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="759" mass="85128" checksum="64C45B7034471A03" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDK6</accession>
    <name>A0AA38KDK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="32287" checksum="9E44B18489A0F741" modified="2024-01-24" version="1">MAPYRAWCFSVPSLQSVSTRLVRLQNIFILLDNSRHLAFRVNCLDMHFQSLIPFVAISLSLAANAAPAIDPIYARSRNAVESSHNILGTSPKLDAQVVSDSSSGFSDIYRRRMSKAAKQRKKAAQLAASAKATNSPVNNVLHTAGVPGAKLEQHNPTTLNPAGETGKEGEKKVDPAHHTSLPEPLSGSQAEKKPGETPAHPPIPGEQHGTPKTQEEEEKEKEAKEKAAHPNEPSPAVSSESTASEEVTSQKPGKMDLAINALGTIKSAADAVSAIGGIANPGAAGAAGAAGAAGDELKGGTGMDDGRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDM9</accession>
    <name>A0AA38KDM9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_367626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793593">
        <property type="protein sequence ID" value="KAJ3781166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="649"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1350" mass="144059" checksum="A5FC7F81C4D5073B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDS2</accession>
    <name>A0AA38KDS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_320343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793562">
        <property type="protein sequence ID" value="KAJ3781406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDS2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="43879" checksum="6931C64FD38B634C" modified="2024-01-24" version="1">MSISFETRRYVVFSILSLLGLLYATILLRGGLRQSSSSGTPISAQLGSTIRRENATLVILARNSDLKGVISSMRNLESRFNHRYQYPWVFLNDEEFTNEFKGLVLLETNAPVHFGLIPKEQWVQPAWIDEGKAEESRHRLKEQNIIYGDSSSYRNMCRFNSGYFFHHPLLQQFKFYWRVEPDVKYFCDMSYDPFQYMIQNNQTYGFTITLLETPETVTTLWDSVKEFMTKYPQYIANDNALEFISSDGGKTYNMCHFWSNFEIADMDFWRSDAYQTFFEFLDAKGGFYYERWGDAPVHSIAAALFLPKHRLHFFQDIGYQHASYQHCPSSDESLGNSCSCHRWNTIDYRKQSCLPQYNAMLLNKATPIVNDLSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KET3</accession>
    <name>A0AA38KET3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_60108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793433">
        <property type="protein sequence ID" value="KAJ3783161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KET3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041295848" evidence="6">
        <location>
            <begin position="19"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="89"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="479" mass="50754" checksum="5F4A4BCB49942A2F" modified="2024-01-24" version="1">MLFSSAISLAAALSLVSATPAIRRYVSSAAPRKLTSPLPAADYSVPITASVPRSKAKQSLLQSLRESQAAKAGSNFTTVLAGSDFDEEYLTNVKFGAQEFMLIIDTGSSDTWAPQVGYACFNLENKPVSQSQCAFGTAGFDTNASTTFRTDPGTNFNIEYADGEFLSGTVGFETVTVGNMAVANQEIGVVNKAAWDGDGFNSGLIGFASPNLTFVFNGTNPNDDDTQLPYNPFFYSAVQQGLVSHPFFSVALNRGSFAAENSSDLDPNLGFIAFGGIAPVEVTDAAVTVPIQGYNAATFTPENGTDVTYFYYAVDVERMSFTGNDLVFGTTNNIILDSGTTLDYVPTDVADAFAAAFDPPAIKDDDFGVYTVVCSATVPEFTVTIGGVSFTVDPADNLFPLGIQDDEGNDLCASGTFDGGPSTGAEGNVFILGDTFLHNVVATFNIETDEITISQRAPYTSESNNARRRAPASVRRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG79</accession>
    <name>A0AA38KG79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_313132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="242" mass="26851" checksum="A4EFDE50DF584905" modified="2024-01-24" version="1">MSTAKNTKKRPRNSSPTAVAYKKLKLSSADSYVSLNVASTFLPENNVKEVLPRQPESTERVKPTPRIRKLTPARPFPLVPTSMSASGPRSAHTEGKNLICITRMTSLGAYMRRCKNIIIKDGYKTLHLSAMGAAIPLLLQLSLALPPILPFAPDEIHTEIHTGTVEVQDEVLPEDEEEDITYRTRGKSTLKVTLKIGDGEFSGGPTRNTKRRRQGKARERAGEKKSEPMVYDEPEQVDAEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGA7</accession>
    <name>A0AA38KGA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_269056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793339">
        <property type="protein sequence ID" value="KAJ3785531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGA7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17934">
        <property type="entry name" value="DEXXQc_Upf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13604">
        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="506"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="630" mass="70955" checksum="FCBC59694359AFC8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGI9</accession>
    <name>A0AA38KGI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_427692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000054">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="73" mass="8396" checksum="EA9C5E6DE5C1A8F4" modified="2024-01-24" version="1">MALIEVIANDRLGRKVRVKCSPDDTVGDLKKLIAAQTGTDHTKIQLKKWYTIYKDHITLSDYEIHDGMSLEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH19</accession>
    <name>A0AA38KH19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_407467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="177"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116110" checksum="D26A33A551B4A9CE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKT1</accession>
    <name>A0AA38KKT1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_368674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793661">
        <property type="protein sequence ID" value="KAJ3780749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKT1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041426815" evidence="1">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="311" mass="33095" checksum="51ACFF928BBC9AC8" modified="2024-01-24" version="1">MLFLTLSWIIVLSTVFRTQGVALLTKRATVCNGHAVLCGRPYGNTTFLGSHDSYAFSSDPLALARDQEVDIPTQLGLGVRFLQAEGHLNDGVLHFCHTSCLLFDGGTVVDYLTTVKTWLDANPDEVLTLLFTNSDGLSIPDIWAPAFVAAGIDTVSYVPPTNPMTRFDWPTLGDMIDSGKRVITFMDAGADGTDGAPVDYILPEFTMVWEPPFDATDPSFPCSVDRIAGPLSTEDHLNMLNHNLDIDVLGTGVLVSDPEDASTTNGVASIIANANGCAPLAGGVAPNFVMLDFVNIGAGMQAVDQLNGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL01</accession>
    <name>A0AA38KL01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta(14)-sterol reductase ERG24</fullName>
            <ecNumber evidence="3">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">C-14 sterol reductase ERG24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol C14-reductase ERG24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_124926</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="3"/>
    <dbReference type="EMBL" id="MU793618">
        <property type="protein sequence ID" value="KAJ3780989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL01"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3780989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="446" mass="50571" checksum="89AA13A8159312E7" modified="2024-01-24" version="1">MSKLNPRTTKYEFLGPPGALLISIGVPSMIYGLYYGCSEQTGGCPPPTLTLSKLTSEITTLPLTLPLHELSWWKGLWHEVWDTDAALMYFAWYAFCVVAWRVLPGDQVEGIRMRDGNVKKYKINAFSTFLLALGLVTGVIFRYGPENFTFLYERWIGFATAAIFMSVFQAFGVYAISFREGALLAQGGNSGNWVYDWYIGRQLNPTLSIFGAEFDIKSFNELRPGLILWALIDISMMCEQAVRRGGIGGVTDSMWLVLLFQVGYIADGLYNEPAILTTMDITTDGFGFMLSVGDLAWVPFVYSLQARYLVFHPLVLGPVATALIIAVNATGYHIFREANGQKNDFRNGKDTRGLEYFTTESGSKLITSGWWGRSRHPNYFGDLLMALAWSLPTGFETPITYFYVTYFAVLLIHRQRRDDENCEKKYGKDWDKYKKIVPYRIIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL60</accession>
    <name>A0AA38KL60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793738">
        <property type="protein sequence ID" value="KAJ3780435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="18959" checksum="37EF30DBD93D514F" modified="2024-01-24" version="1" fragment="single">MADRSSKDIIKLMWNMSSILALDPCRRFTLGFTIEDRWFRLWILNRGTLLRAQAFDFIEDQRSLVTVLLSFALSSAENMGWDPTITFSHLDFDNWRQYNIIVNERVYKTVTTLSDYSADNPLGRATRVWKVQGAQGNTGVLKDLWLEHDRLEEHQIYANIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMJ1</accession>
    <name>A0AA38KMJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_60499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793434">
        <property type="protein sequence ID" value="KAJ3783149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="255" mass="27277" checksum="4EE6CD6CDCD471F7" modified="2024-01-24" version="1">MDDDVLDWDDGEDQLAATTGPIDDADGVSLGSDSGDENENAAPPVEEASASTRIASPSAQGVNGTSRPASPKVSTSLQRKDSSSSLRTTKPINSVSVDSPKTQNRSQRSKSKILTSAQMMMHGLPPKPVTSAVSFLPSSQSSLTEATAMVTRETAKGKGGGGITKTSAANPVHKDDVGSLPPHWEIRHPRSGGKQIYFYNNQTHESTWTHPVSIFPPHPLIRTIKRAASTTMQEHQSRPPSCFPLSLSFHFHRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMR1</accession>
    <name>A0AA38KMR1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_318347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793467">
        <property type="protein sequence ID" value="KAJ3782580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMR1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="110546" checksum="A42E8A093B3F79F8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNN5</accession>
    <name>A0AA38KNN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxidase</fullName>
            <ecNumber evidence="7">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_357980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MU793379">
        <property type="protein sequence ID" value="KAJ3784364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF53">
        <property type="entry name" value="HEME PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 7 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041482765" description="Peroxidase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="537" mass="58079" checksum="D864C0F4CC2FD36A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNT7</accession>
    <name>A0AA38KNT7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_120992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793596">
        <property type="protein sequence ID" value="KAJ3781146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNT7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="596" mass="66738" checksum="E26FBACBBA50D9F1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP80</accession>
    <name>A0AA38KP80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_13482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793358">
        <property type="protein sequence ID" value="KAJ3784934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="215" mass="23830" checksum="2FBD38F49795DB60" modified="2024-01-24" version="1">MPRPSLLGSMEPLDALCQHFNVVKTFPASGIPLPRYFDMPVTRDAHMPSHALALYQSTTTSYIQPLIVPIDADMYNNGFRVDIFPSSAPGSTSPVPYPHPNSGTLTVSLPIVPVSVPHIASIPLLLLFGLGLETQTNSLALHLLTPQVISEFPNSAEMAHEMSLLAEDEFQRRVKYNQGMWKNVLALGIKDSRIVELVQTAWNVTAEARRLRQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPZ6</accession>
    <name>A0AA38KPZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_387854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793357">
        <property type="protein sequence ID" value="KAJ3784965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPZ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="479" mass="50976" checksum="9CEB245618E128DA" modified="2024-01-24" version="1">MSTSLTQSLNASTQKTIQDHYILNATNLAPPQSLAAYEAEIKKTEISPFLTFSGIDRIANVFQKVLSEGSEHMSDPSDIAIALKAFGSELFLDKLSPTGAADQLIAWLGGVQCPLPEDRLENLVRLVVNGTAGVFKRDRKKRQLEGSLGSGLTMPVPGGKDIIRTNEKDSKVSGLSKGEKRPLGDSVKGFSKKRATGIKGIFGSTGIQPTSHSRRPQIRGPPQNSHRHAVYFDNDVSATHSSSRQLPTDSNVPAINQASSPDASESPSSVDAQMLASTRTGVSLAPQSAPGRPSSIRSSALDTNDIEDLSSIRPNIQSPAITSDSAHSSHLDSVENGVKLQVSMPTASSVSTLPKRAVEPENLDIAGAKTAAAGSQDFFPESTSTAFNETQHVAITTGSPQISLLPTGPEESRQNSSTSYSTMDSVAFPAPSTSNGNLPRDSFNSSDSSSSTNVQPLVFNITYNHTHHHHHVHNHYHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR19</accession>
    <name>A0AA38KR19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GGU10DRAFT_352380</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.30:FF:000001">
        <property type="entry name" value="DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="7"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ3786240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="788" mass="89456" checksum="25CF1D93C57B6135" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR27</accession>
    <name>A0AA38KR27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_272390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793396">
        <property type="protein sequence ID" value="KAJ3783966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR27"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="91257" checksum="016EEF941E7718C3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR61</accession>
    <name>A0AA38KR61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793293">
        <property type="protein sequence ID" value="KAJ3787394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR61"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="85793" checksum="2B4FD69489CFC2BD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRN3</accession>
    <name>A0AA38KRN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clp1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_20787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40377" checksum="211B9E5B129C7564" modified="2024-01-24" version="1">MIRALRARNFSKRPTENTPPVKPAPKSVRRTRTRKAKKNITAAKSDAEQAKKKAQKTAQPVRLNVVFYGNANGGADVEMQELPSTSQHPAIVPVTLPRALNQPPVSEPSEEAIAASTGPSYCGQPAAFVRDNLESSGPRSLRTLCSVVTQVDSAVLPKELDIVVNDPAATDYPTHMLAVYAPVPKKPENAPASWVPPKTDVKMYPVHSLFMAAHCAKLGPFPPSPTAFESSPASNEPRSITLPVRPLCLPSPSTFPYLLHYFYLRREEVLFRAFFPCEFSTQFVENCTSEEEIRSLATHIGRTFNPSIILKHAKVIHGVWQNACALGAFDDALWMAIDSAYEVIINALAIGTGNPRAVYVAKSPSPPMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KS21</accession>
    <name>A0AA38KS21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_238506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KS21"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13502" checksum="3242158ED8672D89" modified="2024-01-24" version="1" fragment="single">LDTLATRILLCNSSSGTPTAYGVEIAPGAALPVASNFQGKAILRTENITVKRELSGIGNSSHLQEFGITPILDLPGVGNNLQGKLLCNHDEISIIWRMKQNFSLLNGCVLQPDPAQDPCLKFWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTG5</accession>
    <name>A0AA38KTG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_350069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3787011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTG5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="57"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="281"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35797" checksum="BA046EA7616431F0" modified="2024-01-24" version="1">MEDGEIRSESLQPEGRRHRSVSWLQVAHPKTRLRLVVMNSQTLPKCRVAVIDGYPEVQLGRDNPVSDQIPRIRLKEMEVSKVHASIYWDRAWDGWGVVDMGSKHGTYLRSTHLTQGVGHNLRLSSAKTASAPKRLQHLDHLTLGTTVFVVHIHVNQLACEQCSPGKGEEIPLFASRREFSSHSSSNPEWFSGSEDTRPLPKAALSHLKHQLMSKLGHSTNAVSATHYVDRSARRRAMYSASSADAPGMPTSCIHSVPQELSKVSLQLNPEPASEPAAPIAASSIGHKLLIKQGWHPGTPLGVAETGLVEPLDIKFNRGRSGLGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUI9</accession>
    <name>A0AA38KUI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_372826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="440" mass="50021" checksum="70DF5352B3F322B0" modified="2024-01-24" version="1">MALGSPSIPEQISQITDQLVLLSQSLEDIKQRWEQENSEVDNLRTELSQARAFNRIFQTRNETLEAQLARRKSSRARKTLGRILHEDVARVNARLAHAQRHDLISNTDVDIDGNVESEQESGGTSLRTERTRDYDPQPVAATDSEEEERKEEDMPDDSEYLSPSIQTNPSASLTSPRPFNNRVEAVATGSHDKSPSSSTKRSRVYQEVASVKSASSATLPSEFPPESFTVRPNAPRFTIQIRKPPVSAKVRCGPMRRSHLSKKLNFDEDAAVTLRTLLSNNDLELSLRIQGDYAFVYDPIFLEDTTTSATYLFDWGTLEDNQNTTRYIQEKSAQKDSVFHTFVYILKPRRWYYVGAQKWTQTDLDWDIWETFGEQDHVRSKVIQRLYDHCGNILERETIAEMLSSGELKQICIHLSGDGHIDSSRAMCIAMDYSPPAKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV15</accession>
    <name>A0AA38KV15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_317342</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000055">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="289"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3783132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="778" mass="87581" checksum="EB1497A91519695A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVW8</accession>
    <name>A0AA38KVW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_333564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793360">
        <property type="protein sequence ID" value="KAJ3784902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="33318" checksum="879FEA7600649B26" modified="2024-01-24" version="1">MFIDSVLFARADTTTSSASSLTTSVSTSNSTPTSTTVTSSGSSSSSSSPSSSASSSTASTSASSSSSTSSSTQSTSITSSASSTSASASATSSQSSSSSNGKEIGAIVGGVIGGLVVLTLLSVVFTALRRKRRNAKKRPRGSVYLGNMDQNQLDTFLKQKPRTNVDSLHSSSSMPLLSLPQVDTTLQHDIATEYTDDPAPNSYRDYQPNAAQGNDQNGTGGESESGHSLFLPSPYSQHGHDGNGDDVPPELPQPRLMTPSLRPESQFYEPIPVQVGDFSMKALEESASGSRSSTPVSLSMMHGKNGVNITSSPPVHEENASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVW9</accession>
    <name>A0AA38KVW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myosin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_356369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVW9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="91110" checksum="D5FACD6A0851615C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY18</accession>
    <name>A0AA38KY18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_362605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793450">
        <property type="protein sequence ID" value="KAJ3782843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY18"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3782843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="491" mass="53598" checksum="399DD4CA4FEE898B" modified="2024-01-24" version="1">MGLLFNTFIAAFSSIGAFLFGYDSGIIASVLTMTRFEAHFGANPSIQGAIVSTFSGGCFFGAAIAGWLNDRYGRKRTIQFGSFIILWGCAMQTGAHNTATLIIGRIIAGFAIGILSMTVPLYNTEIAPPKIRGFLVGLTQECIGVGFLVANWVGYGCQFINSDASWRLPLALQLLPAGLLLVGIQFLPYSPRWLLEVGRDEEARKVVYILHDTRGSAELEEAAEKEYNEMHDTIKAEFLLRSRKISDLWATHAMIKRTLISCAVQIFTQFTGINIISYFGPLMWQSLGMTGGKALLMQGIYGVVGPIATLIFIFFIVDRVGRRKPLIFGAATFVATFSIVAAILATNPVADASSKPADPGAQIAGIAMIFLTNIVFSASFGPVSWVLASEVFPTSTRSIGTSVATCCNWAFNTMLSQVSPIGINNIGYKFYLVFVCFNFVNLIVIVLFFPETKGKSLEEMAELFGDSILDVERTENRREDKTSDNDAKYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZN6</accession>
    <name>A0AA38KZN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_353106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3785993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8622" checksum="0E4A78E1F9B42A61" modified="2024-01-24" version="1">MITEDNRGKHGVLPGIKGHLNEQVFPQPHQFYPLCANHTNLTILVIPMYTTTQTPVSQANCGSSSCGCGASCGCKPGECKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L056</accession>
    <name>A0AA38L056_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_385995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L056"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="147" mass="16195" checksum="B9B1DBFCECFD31C2" modified="2024-01-24" version="1">MSATTQTIHLYDRSVFSKDERAVLQVAENFLDGIGARDKILMTEQVLPSGGAVLMRNGAPIFTNLTGVIDRIPFDSPNKIEERISGQPIVRIDTNIAMLWTPYEFLINDKVDHIGTDIWSFAKLDGKWLVSGVADNALIPDASAGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0F0</accession>
    <name>A0AA38L0F0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane bound O-acyl transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_307927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0F0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="249"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="405" mass="45849" checksum="48E65AAFD1CE581A" modified="2024-01-24" version="1">MFVHATREELSFSSFWLVLVPPIIGYYVLAVLVCIPGYRSQRTGIIPPILLLAYRAATTLDLSFANERLVYLNKGLVLAMTTLGFRIIVWVQSSQPYKRLQRIETDSRRVSGSAIAYNRRGQLYLDASDLAFGLRGIGWNWSQGLHIPSETRPTSSKTSFAFWTLHSLAFHVLVFDFLHYLVQRFGPGTFGTIFGGSIFDESLPPLIRFCRSTFISFLCGLVVHCAIQIAYDFCTLIGVVVLRQLPAQWPPIFDEPWRADSLSDFWAKRWHQLFRHFFIGLGWVPLYYVFGRFGGVLGAFFVSGILHYLGLWGLGNGSDVFGMIGFFMLMGVGVILEGFWRKLTGYRVGGWIGRIWTALWLLGWSNILVDAWARKGLIGSLFIPDPYRLPVQFFGAIPARTNGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1M3</accession>
    <name>A0AA38L1M3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793976">
        <property type="protein sequence ID" value="KAJ3780022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1M3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="64476" checksum="D3BA39AE44038534" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L273</accession>
    <name>A0AA38L273_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_366409</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793548">
        <property type="protein sequence ID" value="KAJ3781537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L273"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF9">
        <property type="entry name" value="ENDO-XYLOGALACTURONAN HYDROLASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041218294" evidence="15">
        <location>
            <begin position="23"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3781537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="398" mass="40649" checksum="AB832280F7779A9A" modified="2024-01-24" version="1">MAARLGLFLAFLYLVLPSLTLGAVLQKRATCTPASHGEAGVDDVPAITEAIQSCGNGGIILIPAGIVFQLGSTLSFAGCSGCEMQIEGTLKLTDDLDAWNGVKAIVLLDDITGATIHSVTGSGLLDGNGVPYWTEFNEDSSYSRPTLVYIDGGSDITIENLLVRNAPNVFMSAAGDATNIHYSGLTMQAIPSNGVTPKNTDGFDIGPASQVTITNVIVDNQDDCVAFKGGANFVTVTDISCSGSHGLSVGSLGEGTSGNTVTNIYVSGATMTSSTKATGIKLWDGSSGHGVATVSNVTFNDITVDSSDYAAQIQVCYESTGTCVPSTHQLTDIVFSNFKGTTSGAEGSVVANLDCPADGTCGIIFESFEVNPPSGSAEILCSNVPSSADITCDGAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2V8</accession>
    <name>A0AA38L2V8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TBPIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_300853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793689">
        <property type="protein sequence ID" value="KAJ3780610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2V8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="7">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3780610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="236" mass="26474" checksum="D2BC4BC5AF62C0FE" modified="2024-01-24" version="1">MASKQKSDVKVLKGQEAEDKILEYVRRMNRPYGAVDVAANLKGAVPKAATQKILVALAEKGELVQKNYSKTTFFVANQAKIDTLSPEKISTLEEEYKKLDEENKGLALQIKSAATELSRIKNLPSDSELNEQLTSLEDAIAKRISLLQPLRSGAPPISAEEVAQIDADWLKWREEWIRRKKIFNSLWVLATDSLPPQDAIILSEDLGIEHDTLEHAALEKGQLCIDTKKNSLKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3I4</accession>
    <name>A0AA38L3I4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_277038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793530">
        <property type="protein sequence ID" value="KAJ3781720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3I4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041489120" description="Hydrophobin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3781720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="109" mass="10714" checksum="27DA5E2D804E2234" modified="2024-01-24" version="1">MQFKLAFVTAVFATLAAATPTPRTEPAGSCSTGPVQCCNTVQSANSSGIAGILGLLGVVLEDLDVLVGVTCSPITVIGASGSSCSAQAVCCEDNSHGGLISIGCLPVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4R0</accession>
    <name>A0AA38L4R0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_353381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793328">
        <property type="protein sequence ID" value="KAJ3785932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4R0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="63" mass="7039" checksum="445D3E366861D229" modified="2024-01-24" version="1">MSSQQNNSNTQQADSPRAPRRTPMACQFCRGRKLKCDGSRPSCGNCNRRGFPCEYTPVSAEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L614</accession>
    <name>A0AA38L614_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_433842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L614"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24407" checksum="F641827861FE10BB" modified="2024-01-24" version="1">MSSSSVLSEERGARGIPKAPFIQDVEKHIGGADAEVEGPLKAIQDAISKYRYMDSNLTQRRLGLEEKIPDIKKTLSMVEYLQERREGKSSQSEDDLEDDLEDEDSNSKPLKTTFELNDTLFAEAELEDTDTVYLWLGANVMLSYKLPAAIQLLRSKLEAAEANVASLTEDLEFLREQLTMMEVNMARVYNWDVKRRREHRTAEEQGGKSASEKEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L615</accession>
    <name>A0AA38L615_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_373051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L615"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041344914" evidence="6">
        <location>
            <begin position="20"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="56"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="716" mass="77038" checksum="D6B7781C270454DD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L665</accession>
    <name>A0AA38L665_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_92552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L665"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="264" mass="30594" checksum="FA9D7F537F55FBC2" modified="2024-01-24" version="1">MANTTVSGAKAIHGQNPQYLVETVIRNRIYESNYWKEHCFALTAETLIDKALELNCIGGVYGNQRPTEFLCLLLKLLQIQPEKEILIEYLRAEEFKYLRALASIYIRMTFRAVEVYELLEPLLRDYRKLRLRNMAGYTLTFIDEYVDSLLTEERVCDIIMPRIPKRQILEENNDIGPRKSRLLDALEGKSDDGRSDKSRSHSRSRSKSLSRSRSDSRGRRLSGSPLNDRSRYISRSPSRSRSRSRSGSVASYRSRSRSVSLDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6A4</accession>
    <name>A0AA38L6A4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TKL/TKL-ccin protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_344555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6A4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="697"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115371" checksum="C6C2FFA283F26C04" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6W4</accession>
    <name>A0AA38L6W4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_107668</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6W4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="335"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="624"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="16">
        <location>
            <begin position="856"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3788470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1209" mass="135001" checksum="721DA2AFD7B21043" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBL8</accession>
    <name>A0AA38NBL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_336273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793547">
        <property type="protein sequence ID" value="KAJ3781546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBL8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041383598" evidence="2">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="127" mass="14043" checksum="BB9A461BD8F510C1" modified="2024-01-24" version="1">MEPRDKARALLIVVLRLLFVISIETEPVELNTTHLHSPKTLWNLTGTVLTLERIMIEVPEAPDEVPSVGGGCDTRRYSKGLHGPWKYDGTSAKLSATLPTRYLGVPAKCKEERSSGASDRTDQSIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBX9</accession>
    <name>A0AA38NBX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dak1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_378718</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793484">
        <property type="protein sequence ID" value="KAJ3782326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="411"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3782326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="616" mass="64773" checksum="E8A290268B6BCFF6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCW7</accession>
    <name>A0AA38NCW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_355441</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="MU793347">
        <property type="protein sequence ID" value="KAJ3785296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCW7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3785296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="464" mass="51460" checksum="3901B5AB20EA3BD3" modified="2024-01-24" version="1">MGYLSDEALQNLKKYAYKGVDKSILSKWIMNAFWSWFVTLWPLSVAPNTITLSGLCIVILNFITLLYYDPSYVTEKGGAHVPQWIYFTWGIGLFLYQSFDAVDGKQARRTGMAGPLGEMFDHGCDALNTTLEAIIAAQALNLGQSWWTLASQVAALGNFYITTWEEYHTGFLFLGVCSGPVEGILMLVVVYLITGIYGPSFWDTGILDFLHLSNISLIANTIPNIGLNVAFMVFGAFVLAFNIIASYSNVRTAMRKSGKSTTKPLLLLLPFLFSAGMQIAWLAHPKLDYTADAAASTRGVFKVHSPSFLPSPSPSPSPPSLLLYDDEGFTILSSSLFVPFLCAWGLQFAHQVGRMILAHLTKGSFPLWDWLWVMSVIGAIDANLPRILGKPPIIQSTPHITAVFVYATLVFSFVAYARFCTLVINDITNFMGIACFTVRKKDKEGRWRSVLEETPEAVEGRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND22</accession>
    <name>A0AA38ND22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_353871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND22"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="52"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="735"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="844"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="408"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="127"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="876" mass="95415" checksum="D97FB1DCE8F72034" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NE09</accession>
    <name>A0AA38NE09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_346453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NE09"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="180" mass="19882" checksum="FA81266C081CB4C0" modified="2024-01-24" version="1">MTAMLRAFGRLSTNPLYSASAGPSRLILNAQKDIYVRNASLLHQFRSFHASPPTLATMNQAMKRKKPPPRRTALTSSPLLEQSPQRKGVCTHILIRTPKKPNSARRKVARVKLTNGESVMAYIQGEGHNLQEHSVVLVRGGRVKDLPGVKYKICRGALDFGGVVGRSTARSRYGVKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHQ8</accession>
    <name>A0AA38NHQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_379413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793545">
        <property type="protein sequence ID" value="KAJ3781562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="191"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="329" mass="35486" checksum="CF0BA8B49FDBA10C" modified="2024-01-24" version="1">MRTKTPAIAKRSRSQTPDRSSRSGLFGPPSPPPPSRTYGKTKNRSRPSTPRHAASTRTSPRHSSPPIASSSTSPSHRIQSLLNYEEPVVLTPTSSCSSSSILFPTDLNLYTDTLSAPQSPQAKAQDMTMASNDDDEPVFLSMRLVPVQPKPPGGIALDGEAKQVSVLKSALQAAKNRIKALEDAAEERNMCGCCKDVMFQPFILSCGHSICKDCILRLSAVYLGARMNYACPECRTVQGRFTPIPNYSAQSSVNDMLQLQGINPPPHSPLQWPVKFQSRPMTFPFPLRNGTYPCGSALASASILTPAPALALTHASVPAPFPIAVDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI07</accession>
    <name>A0AA38NI07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_389800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793471">
        <property type="protein sequence ID" value="KAJ3782507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="20097" checksum="38F9E86684AD1C71" modified="2024-01-24" version="1">MTDYPDTVDMLIGTSLTFEPQLRIVRVRGGADDEILRVPTHWHENHDEIVAVLEGKLKVTIGGKVTLCTPESGEAFIPRGVPHSMESLKGVSCVVTERTNPAKFDKKELFFRNMFALPGSLSQEGGLLPVMQIFYHGDIYPVFRVHLRWLEKAVVKVLGGYLAPLLGYRLKYKSLKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIH9</accession>
    <name>A0AA38NIH9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794251">
        <property type="protein sequence ID" value="KAJ3779763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIH9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="286" mass="32479" checksum="5C5B8216FF2B12ED" modified="2024-01-24" version="1">MHAGWHVLASLKSPRNVRSPPLTPTRWFGGLFSFSLIFVEYLGGTCWINSRPILERQLYEPFLPFFFLSQKPSTVLTASNPKKDMQTSAPLSTLLLIFLWILSVLASPLPPIDDSTQVSRSYRRADSQAPDAHAKPKYQVKLEIAIALKNTVKEHSFLVIGNTIIHAEWSDDYFDGPEGIPTPKALTPKLYKLATEETRVKKKRWHWISIGEASFNGKEDEENIIKSALAIEMPPYEHNGNCRDFIKMVLGMLHERGFVDESVVKGYGEIYEERARALQEIMSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIQ0</accession>
    <name>A0AA38NIQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793868">
        <property type="protein sequence ID" value="KAJ3780183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIQ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="146" mass="15970" checksum="79BF19B4BC97578E" modified="2024-01-24" version="1">MAFYLTWALAAPNPTQSYPTGTLALATTAVFMFFLTSTGFQIPNSTTPAAKKKKPANSPDNFSNKWAFNAMRFFNLIQCLKGNKWELIFHASKSYILNIPNAGAGPYLKVAQQEAEKANAQHGMVMNVSQFELAEAGGNDDIILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJB5</accession>
    <name>A0AA38NJB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_380520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793712">
        <property type="protein sequence ID" value="KAJ3780529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJB5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="941" mass="103335" checksum="7B10C27F1201291A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJN0</accession>
    <name>A0AA38NJN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_97223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793528">
        <property type="protein sequence ID" value="KAJ3781743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJN0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041296450" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="165" mass="17202" checksum="024A435E22FBDE82" modified="2024-01-24" version="1">MVSSLATTVLTILCGALYACSTPLSSRQVESGHGILSAPTSGIVVAQGSSFPFEFRDSNWCEDGYSPIAVWLTDYAPSASSLNSTGQFAEGGYTYYFGSYLIPNFGLPVLSGSVPPPSSLVFPVSSDLSVGDEVYLAVVETGNNCPPGLNVPPQYELSAIPMTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJX9</accession>
    <name>A0AA38NJX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_86361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793494">
        <property type="protein sequence ID" value="KAJ3782178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="466" mass="51189" checksum="9CB451A8F2B13B35" modified="2024-01-24" version="1">MSNPPSPRPANSSPTNSPSSEVPHTSTSRTETHEDIVAAVEHNYPASSSSTFIHHSTPEPAPSRIRPREDDSEQHVAKRFHADPMSSRQSDRSSPSSDSQGEMADTEDGDQSRRSPAPSEPPKKKRTRTLTTPHQSAVLHALLAQSRFPTTAMREEVGRAIGLSARKVQIWFQNQRQKARRPRTNNEMPMTRPPQYGPFPSAGENEFLNLYPRPQQSGAVTAEPYSPVTPSSYSSPRHPTYTSPVPTGLLGPGVPGHGRSRQSQESQSPVAVTAGPSSSHYMRRGFVPRSPSPRRTYNLEEARPSTSHASTSTLRYRDPARTLPPLIFPPQGSSAGTPSIRSAPANMPPPPFQHARSPQFAFSPPPSASIEPEMVPTIFPPPFTLEPQPQWNDPIYTSMPSIGSTSRSRRSSERGSFSPTHPRAIEPLRTIPEHSQPSREGRYDPVRSTVPTRPLSSPDASQHEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKK3</accession>
    <name>A0AA38NKK3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_144096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKK3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01795">
        <property type="entry name" value="Ubl_USP48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044743">
        <property type="entry name" value="Ubl_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="156"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="943"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="948"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="967"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1073" mass="121792" checksum="FC00EDCF7B194750" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLH5</accession>
    <name>A0AA38NLH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_293866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793368">
        <property type="protein sequence ID" value="KAJ3784668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLH5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="482" mass="54346" checksum="69EDAB975978FB57" modified="2024-01-24" version="1">MHSPDSVHTLDSHLKSLRDKKADLLRQLEQVNTDIAVAETKRARIKNGNASISKLPTELLSHIFLLCQKEFHAFQITASQVCNRWKDLSNGTPLLWADIRMSLEHTSHIPSRLQKLETYLTRSGPSSLFAARIHVKSNINFSSFLSLIADHIPRCAHLSLSVQRHPKACLLLREHLECLRAPQLDHLALHVDWADSGPYDRIMGIVPLIFKGGAPSLTSLQLSGIAGALRPPISNELTTLHLDGEYMLDLTVLKYREILAATPSLVNLSLGGLKIDSSATEMEERQTLKLSRLRTLRIRAKGTDHPFTSANALLTTLPLNQLENLILCDVDDLWLFDFPNVKDLSLYGCEFGVSQIGRLMLAFPSVVSLTLESASLLYMALSVEGEPIWWPNLRTLHVRDLAVHDVSMLLRLVQERTNMKHPLELVCFDTSSRRRASSILNTLQSLTHVSRISNYPEPWPPGGNVVLTEDDNFWDIYWYPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLQ7</accession>
    <name>A0AA38NLQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_313798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="165" mass="18967" checksum="D0E22362AF0472C3" modified="2024-01-24" version="1">MSMIFNKNDIYAALTRSDVRGAFHWAIYLVIDQKTGYRLHATTHGGRTPWEYECVLWDGPEFVLAVTFTLIGQLHEDLDVECLEAYVKDIPMNIIPRDQQREPKFTCRVWFKEAIRQIHASGIFVNCPDVDALERELLTKTTAMEYLGDERLPVQGTSACAKPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM05</accession>
    <name>A0AA38NM05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_355223</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793345">
        <property type="protein sequence ID" value="KAJ3785344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM05"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3785344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="34634" checksum="36315A2F000568F7" modified="2024-01-24" version="1">MSRPQDDRNQEATVYLGNLDERCTDALIWELMLQAGPVVNVHLPKDRISMAHQGYGFCEFLTEEDAEYACKIMNQIKLWGKPIRVNKASSDKKQLDVGANLFIGNLDENVDERLLYDTFSAFGMLATTAKVARDPGMGTSKGYGFVSYTDFEASDAAVESMNGQFLMNKAITVQYAFKKDGKGERHGTQAERLLAAQARKNNALPVSARPPPAVMPFGAPPMAGYQGPYQGQFAGALAQPPPPPGFTPQQTIMPQMQMQMQMPMAPPSMPMQMSGMAPMPPPQGMSMYGSFPPPPPPGFAVPQYPGQLPVPPPQPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM20</accession>
    <name>A0AA38NM20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">chitin deacetylase</fullName>
            <ecNumber evidence="12">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_269126</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="12"/>
    <dbReference type="EMBL" id="MU793341">
        <property type="protein sequence ID" value="KAJ3785449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF135">
        <property type="entry name" value="CHITIN DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041300696" description="chitin deacetylase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="16">
        <location>
            <begin position="149"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3785449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="397" mass="42765" checksum="A7CBB95187212A1F" modified="2024-01-24" version="1">MLLSFLLPAFFLSASAAPSLNSRHHGHEHRIVQRLPSNEWFHPRDHPVHRLFRRDADTDGISYAQVGSSTWAAPYPSSTPDVSQLPAAWTDALNAAVQAGTIPNIPQSTSPTPDTNPVYPDGYDPTGPDVCSGTYKCRIPGNIWDAPDGFLGTGFDDGPTTASPALLDFLEANNETVTHFMIGVNIIDQPDSFTRSVELGHDIAVHTWTHPYMTTLSNEDVLAQLGWTMQLIHNSTGGRLPKFWRPPYGDTDVRVNAIAKEVFGMETILWNQDTEDWSLTETGGTTAQAINASMTTWLTGSKTPGLIILEHELSDESVQAFEAAYPVMKSNGWNLQSVAQLAAGGQSAYQNAISIDAGSVTPADIILGDALTTSSVSSTTTSLPSSTSSSFSSRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM78</accession>
    <name>A0AA38NM78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_375139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14224" checksum="E152024EB863614C" modified="2024-01-24" version="1">MISLLDDDGGISESFEKCLKQIFAKYCTPKLTLPLAGDLPSNACLDSTGLHAWALDTNGEPFSEDTKEEILQFMDVTDEGDLTFKGFLQVYQLQTENDEEETWRDLVSPPAFYTTSSSGTSVLVEAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM93</accession>
    <name>A0AA38NM93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_387102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793328">
        <property type="protein sequence ID" value="KAJ3785929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM93"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="63"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="207" mass="23751" checksum="B323B02785232DAA" modified="2024-01-24" version="1">MQHIFSGIHDAALSRQAHYSGWEYDEHIRIKNFDESIPDRHIAAVAVHACKSEVRIQGLVQKYQVAHFRLFLILSAPPSAERSVELNNFSHNRLVTTTEIAYRRYLFSRTETFITVEMASTTTPHPTVREVLDHLFNEKKRHLYQLDSDTGSGCRYWCQTVLKDIARKGWLHNDAPHKTEQIADIIQHSVPGVLVSEVGNPKGGQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMI5</accession>
    <name>A0AA38NMI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_351443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMI5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="478" mass="51624" checksum="CD642C6831415B6A" modified="2024-01-24" version="1">MYNSIAPISLDDVNSHIEDAQRTFNSGIWSKAPAITRSKVLSRLARMLEERVPEIAQLESLQTGRTIREMNAQLGRLPDWLDYYAALLRTRHDFIAPTQGKLLNYVQRVPLGVVAQITPFNHPLLIALKKIAPALAAGNSVIVKPSEQAPLTVLEFAKMAADAGVPSGVLSVIPGFGHTVGKAIVSHPFIRKVDVTAGTKTGRALGSIVGSNLAAYTAELGGKAPILIFNDADIDSAVNGTAFASFVASGQTCVSGTRIIVQNQIYETFMEKFISKVQSIRARMGNPLNPKSTMGSIISLSQLERIEAMVGRTKGRIVGGGRRMTGVSDLDGFDFSGGSFFPPTVVTDISLDDELWQEEVFGPVVVVKKFTDESEGITLANACKYGLGAGIWTTDLSKGHRIAAEIEAGLCWVNTHHRNDPSSPWGGMKESGIGRENGLEAFEAYTQSKSTIVNVDTVEATRRADDWFAEGTEVRRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMK9</accession>
    <name>A0AA38NMK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMK9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="34182" checksum="318E034B9798F1E3" modified="2024-01-24" version="1">MLSSLFSKKNQPETRSESLGHTEATEPKATQIPKGPPQFLAAGIRTLHDDALAELYAKSFEPTDHVAKDSTKAPGSASHSSPGAVPASNREVVRDPFSGHALGTLGLPDLNLNPEAHVPLSDAATSNEEIWSRLSTVLDLQSQIAALHLEIEGIGGKGDQGKGKGKGNMVLTTSKRPPVRAVSGTADLLDLEHDEGVGVGEDEDEEQRKDREREEDFARLADQFEGRKEGVNSIMLKLDELSKALAEFHALQAPNIHFSSSRHSSLPVTTPTSSIQAIKSPVPLPPVISIPNDRLPTNILSPSRMLDSPDSAESHEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMN7</accession>
    <name>A0AA38NMN7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase regulatory subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_160826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMN7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="299"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="766" mass="83457" checksum="45533BE15A13906A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN15</accession>
    <name>A0AA38NN15_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_233383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793969">
        <property type="protein sequence ID" value="KAJ3780035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="96" mass="10931" checksum="A20D68DE64E9AEA7" modified="2024-01-24" version="1" fragment="single">MATGLFKEELASRLGLEVASDRKRSQKICEIYGITPQELQYKWEAATYNHNNNFASVREATRFTSDSLASVRDQIKRELEQDHGSAKRKGQVRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNC6</accession>
    <name>A0AA38NNC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_346085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041401036" evidence="1">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="182" mass="18804" checksum="81BEECF91D08BEF6" modified="2024-01-24" version="1">MCRTMFANVLALVFALLCSQLVNVVGVPSPAADASADLGGLSIGDIINALGIGLVQNISAIITLESLTDNLIDINFTAKNPLIIELTLDKVSSLAGVNNTVYASFDHTFDPPVVVRPLGTANSGTIDNVLLVQGAINSLNIIPLGELDLLDVNVSVRAATIDGFGGIPIPIDGLKQSDVPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNH7</accession>
    <name>A0AA38NNH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hsp90 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_432396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="7">
        <location>
            <begin position="231"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="7">
        <location>
            <begin position="360"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="966"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1523" mass="173088" checksum="700759D236126753" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNM2</accession>
    <name>A0AA38NNM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_306683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="246" mass="26717" checksum="6F54548951CABD69" modified="2024-01-24" version="1">MSYASVAGSNLPPSQPRPDPALLNTEIPAASIVADDTSKVNVVHPDFKAHPATVYSENRPPPDDAPSRKKYSNRRLREAEAEGLYLWQIAKHYLFRPGVAGGLIGIINIGLLAGASRAFYTQPHLRSDRKVIATTAAATLAILGVEGFATEKYAQTPQGQTEARRAKEEGTLIYKHLRENILRPGVLGGLLGLVNAAVLGSVGYFSYIHWDKPTWDRRIVSAVSVGLLTLWGGEGALAERYRAARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPB9</accession>
    <name>A0AA38NPB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_272179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793391">
        <property type="protein sequence ID" value="KAJ3784085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPB9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="109" mass="11803" checksum="FA137467F39E4959" modified="2024-01-24" version="1">MANDSSASDLMHQMYIDAFNGTSDSLRMAMVSPQVVQGTKSTWYGAGGSSILGYSNIPTVGIIPQPDYLWASMVDGGWSRLDIPEAIEQINVILRLLTMLDDAFTSGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPT4</accession>
    <name>A0AA38NPT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_289986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041481642" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="227"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="429" mass="48251" checksum="42B2746C1C80D7C2" modified="2024-01-24" version="1">MFTLTMKRSALFAALHVLVPLVLATSESQVSLSSLSLNSYNQPHLSSTFDNGYDDVDFDEPRLVRFIVEDSHVDAVMLEEPVWVTERVKLDSKRTGDGYIDITEHPNYNPSRYSAAPSPTHVYHPPNSTIVPQILPLLSTQEQRSNLEIFTSFHTRYYKSKTGHASSRWLYQRVLDYTGEYATDALREAVGIELVLYEHKGFKQESVIIRLIPRRSLNSSESVERLHEITIIGAHCDSINNENPFYRSPGADDDGSGTITILEAYRAILQNGYVPLSPLEFHFYAAEEGGLLGSLDISDAYVKAGKDVRGMIEFDMTAWVAAGRPEEIGVVMNGADLALSKYTKLLIEKYLDIPWIETRYPGRAASDYMAWTMAGYQSSHVLEGAWEGVNNRNPHQVTDSIDVSPEFSFEHIMRFTQLAVAFAVELSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQI3</accession>
    <name>A0AA38NQI3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_67348</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQI3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3789276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="445" mass="49835" checksum="48AD0C0C2F12CA11" modified="2024-01-24" version="1">MSDQELTILTLNCWGLKFVSKNRRERVVAIADELSHTEEYDIITLQELWVYTDFEYVRESVAKYLPYAKFFYSGALGAGLAIFSRFPIVATEIQPYSLNGAPIDVAGGDWFVGKAAASVIIVHPILKEVQVFNTHLYAKGGEDGPEHNRAHRLVNAWEFAKLARRAAELGRYVIAAGDFNSIPTTLPMTVIREHADLKDSWLVTHPFSNTPSDVTPSPQEAIDDFGVTADSPINSFSAGKGLDATARRFCGKRLDYIFYRQPHSYNPAELPVLHCKESRVMFTHEIPGTPFSYSDHFGLKSVLQIQTPGALPSSSDTVFPSESQTAAWSTQSSEPSEISQACITKMTQALSSCYRFSKSRAQKELALFVLCLMLLITIAVASTWFPYPWLNPIFIVFAVFLTWLGTTMLYEGYVYGQWECNALMNVVEELEVYAQGLELQSSRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQZ8</accession>
    <name>A0AA38NQZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_49414</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQZ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="16">
        <location>
            <begin position="300"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3789491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="629" mass="71371" checksum="7EA858BCF25B68BA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRF0</accession>
    <name>A0AA38NRF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_342787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRF0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="616" mass="68365" checksum="D9A4FE73B62635B6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS22</accession>
    <name>A0AA38NS22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_341457</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS22"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="308"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="530"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3790031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="709" mass="78409" checksum="3E497E9B27AA2622" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS43</accession>
    <name>A0AA38NS43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_398492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS43"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="411" mass="46441" checksum="4BDB0E9D38677053" modified="2024-01-24" version="1">MYLANGKPRSGYDFGNVFKPFCSLPKELLHEITAYLPVNDIVSFCLVCKEFNQLGLNILYKAIQNVNTRCFDTLACNSRNARAVKTLALPSQVNNQLDIGCTWLGPQENVHDPPSEDVKAASILPYLSGLQNLFVPSFSAIYTQSLSQCDFPNLQSFSYSMPITQPIASFISRNNSIVSLTFDCYLPFFQNFVLRPITLPQLRYLSGNPQIIKIFAQHAPLETVHIDWKYERARIEVFDDALSFLALHCCTTVKELGVHRNTFRQCTCNNQILVKISEKFSRITKLGLNSIDISNGSILMVNTALSRFECLKYLNMDQHPPGAVCPPRLFSSTQLDYDRDEALILSWTSDNCCSELQECQLPNGILWCLRGPKLWLPLLSTVPQRKSLLLDASKWCECRAEAASLDIRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS65</accession>
    <name>A0AA38NS65_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Non-heme 11 kDa protein of cytochrome bc1 complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_341610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS65"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041224120" evidence="10">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="117" mass="12897" checksum="C1CAB62480423F35" modified="2024-01-24" version="1">MSSIASFFSSLLPTIQADTAADEKPADENNSGTDSESSEEAPAEEEEEEEEEPEDLHPAIREECRSSTKCAPLAQHFERCNEKVQAGEGFKGEDCVEEIMMHCVEDCAAPKLFVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSK4</accession>
    <name>A0AA38NSK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_341004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSK4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="36090" checksum="F45B6BCA1F1AEC43" modified="2024-01-24" version="1">MAVSSTIIIIVVAVVAVLLLLLLLVSYYSFWSKSKRKVPLPPVQPLAHDRERSLHIYAVEKERERSLFLQIQIAPSWSDPGTIKSAVSSESGSTANTMGYPPVPPTPLGISSLNRHAPPRPLSLASSAHTSRSNFSRAIPHAPDSNVQIVLPAPLGASTMDYSRDSIADGWVSQVINSSQPIRSRSRSRSQSLPRSYTRSSLGTSYVHTPNPSPSDLYVRNRSRTNSLPYSTSSSNQIPPIPPMPSQYSSSVAQIPPPPVPHTPSVYGQPSSSSLPFHSDAADAENEYRGRNRGRGPSQGRSFTSLEEASAYKSVQQNGRPKMRSRSRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSM2</accession>
    <name>A0AA38NSM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,4-benzoquinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_340710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="21479" checksum="A3EF635065DD9886" modified="2024-01-24" version="1">MAPRIAIVIYSMFGHIAKMAEAVKSGIEGAGGSVEIFQIPETLPQEVLDKMHAPQKPDYPVISVNELPLYDAFLFGIPTRYGNFPAQWKVFWDATGGLWGQGALAGKYVSVFFSSASLGGGQESTAMNAMSTFVHHGMNFVPLGYASAFAQLAGVDELRGGSAWGAGCIAGPTGARQPSALELEIASIQGKHFYNVVSKVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSW8</accession>
    <name>A0AA38NSW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pkr1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_340423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11082" checksum="4F4D5204C04D4E85" modified="2024-01-24" version="1">MASDSTGSDCNHTSDLSTISFFSDMLKPGSSLHPTFLLILDVIFFTLLLTLLGLVFATAGNIHLIALTAIELALWASVKWFVYELKNAPIQEHPDTTKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT46</accession>
    <name>A0AA38NT46_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_146541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT46"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="204" mass="23275" checksum="2A4068053956401E" modified="2024-01-24" version="1">MPGYRLEYASSSRAKCKGPKPCAGNTLPKGCLRFGSTVEFQGKQSFAWRHWGCVTAKVLSNVRDEHPDASDVDGFEELRPEDQQKVIKAWEEGKVADEDIPETARKADGDEDEDDGEKPKRKARATKKKADDDGEEKPKKARATKTKPKRAKKKPRRQKGNLVRRKLQETKTTQNRRKLPRRNVQPRRRSTLTRAKTLPKTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTG8</accession>
    <name>A0AA38NTG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_101752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="123" mass="14004" checksum="58784F68EE22436A" modified="2024-01-24" version="1">MDSFPSNDTKFLELPSSSNGRASGKSWKTSKSATVRSHLPNGVKTKSWAARMEQTKRSLAIKKLETEMKDEKLAEATRRREVTQERRKAAEEKRRLEEDQAKMGARKAARMRRKAGRAKKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUE4</accession>
    <name>A0AA38NUE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L22/L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_1856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. uL22 is associated with the polypeptide exit tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUE4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000012">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3791269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="187" mass="21102" checksum="76BA41463F213C07" modified="2024-01-24" version="1">MVRYAGDALATNPEKTSRARGEYLRTHFKNMREVAAALTGLKLTKAYTYLTNVTEHQQVIPFRRFAGGVGRASQAKQFGTTQGRWPEKSVKFIVRLLKNAESNADAKNIDAEDLYIKNIVVQQAPKTRRRTYRAHGRINPYQGHPCHVEIILAASEEEVEKSTDKPSALIGLNRRQVARKRIEAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TY00</accession>
    <name>A0AA38TY00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_405306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TY00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="543" mass="61249" checksum="B7129818191108E9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYG6</accession>
    <name>A0AA38TYG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_43803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYG6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="972"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="972"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1092" mass="122744" checksum="9C20F5DDEADEE034" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYH5</accession>
    <name>A0AA38TYH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_260580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYH5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="246" mass="28371" checksum="0227B2C4F25A9C34" modified="2024-01-24" version="1" fragment="single">DERLITVWFDIDNTLYSTSAKISQAMGVKIHNYFVKLGLSDREASDLHHKYYTQYGLALAGLIRHHDVDPLDFDLNCDQALPLEEMIFPNPAHRKLLEDIDRSRIRVWALTNAYKVHAERVLRILNLRDLIEGIVYCDYEAKDLTSKPEPAYYHKAMTLASMADPSKCYFIDDNWRNVEAARNIGWGHCVHFCERGLEHVEGGKVIKISSATEANENLKHEEKLGIKVISDLEELRDVWPEIFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYK7</accession>
    <name>A0AA38TYK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_342881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYK7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="24598" checksum="B4E10A38D2E74FAB" modified="2024-01-24" version="1">MLLHISRPVRLLSLLSATTLAAAFRILPIIPRQTTDADFFNPLLNGGSMLDQVPGVLGEPLNVIISAQSSPDVLTLDGIINFAKAIGFSTECLGIHSGAPQSANLGDGNGWVNQTIELREDYGDPTLGTCLESLIGGNHFRVFVQNGTEHPTGALFLAVSTEENVTEGHTTAPDGYDTGRDLFSAAAINNGGTTSFGGTTYSTAGTNITGLIQPGSTGIEDGIATDGIVTLLTITIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYP5</accession>
    <name>A0AA38TYP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_31886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYP5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000131">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000236">
        <property type="entry name" value="Vacuolar protein 8, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000128">
        <property type="entry name" value="Vacuolar protein-like protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="616" mass="66671" checksum="8B6216FB70AE6465" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYU8</accession>
    <name>A0AA38TYU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_392427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3789775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="40326" checksum="7061563F2985FB27" modified="2024-01-24" version="1">MLVVHGINQLNIKGRLEVKMIIARSYATQHTRKALAARTASTPLAVRERRQRQLGLAPGPEETDATPDGLSPSDFARYQRHKALDAIPKNPDGKYQSPKEWVLRRNARRSRIRGFRTIRRIVPTKDDPTVTKTVNEVDVVGQPVYLPNIIFRLVRNHTPEGQDYNPFEATFRIPPSITKTDIRSYLLAVYGIKTTYIRTDLYYGRLKPRGASNRKMRSTYKRAVVGLVHPFYYPHRIEDMPEEERENREQSIEQQYFIKEGQEMFAQSRFRSASVTARGQESKQWKFDAGSVKGRGKILREVARRRQLKEQMVSGLVGDWHRTRMEGKTVTVDPPRSRKPKKEAEAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYY2</accession>
    <name>A0AA38TYY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_342774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYY2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="238" mass="25971" checksum="1A7B889BDA9DF8D3" modified="2024-01-24" version="1">MFRSASSVLQRRAVPLSRCFHPLAGQWSSPPPISSLVPIVIEQTGRGERSYDIFSRLLRERVIMLYGPIRDTDSTLTVAQLLFLEAEDTTKPIHLYINSPGGSVTAGLAIYDTYVSAPIHTYCIGQAASMGSLLLSAGEKGKRHCLPNASIMIHQPSGGASGQASDIAIHAKEILRIRELLTGIYQKHCGKPGERLADGLKRFETALERDYFMTAQEALDFGIVDAILEKSPKSVSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZI3</accession>
    <name>A0AA38TZI3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-lactonohydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_303871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZI3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041284429" evidence="1">
        <location>
            <begin position="22"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="407" mass="45005" checksum="A1194C5ED6669898" modified="2024-01-24" version="1">MLNLLIAVLVTILSLFYVYHSTVPQDRIIRDAYGQISIVNQLDFNVIGAVDSFRDDPHHRYFNPTNHTTPFFQVFEDEFLDVIGSNPSLNVISFDPIFAFAHEAPVWVPDTDEIFFCSNAGGDLGRSDIEHNNQVAKLSMKEVAQAMAEGPVDVNVPQYKIDLPRSVQMTNGGTGLYKGQILLTNEGRGDQPANLVLMNPHSPYNVSILLNHFYGRQFNSLNDVKVHSSGTIFFTDVPYGYYQHFKPKPQLPNQVYSFNPRTGAIRVVADQLDKPNGLAFARDYKTVYVADTGSLIGKFGHDLTLPATIQEFDVDPKTLAFKNRRVFAYADSGAPDGLGVDEFGNVYGACFDGVNVWNPSGTLIGKFFLGTKSANFAFAGKGRLVILAETKIYLAQIKAGGMSLMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0Y4</accession>
    <name>A0AA38U0Y4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lish motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_339006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0Y4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="232" mass="26063" checksum="3D714C672406C328" modified="2024-01-24" version="1">MPTAPPKEQIYKEEWDRRLHEVQISKSDLNRLIMDYLVIEGYKSAAEEFAQEASVASEVDFESIESRMKVREALQRGDVEDAIVRVNELNPEILDNNRALFFHLQQQKLIEYIRQGQVADALQFAHDELAQLGEHSPEFLSELERTMSLLAFEHSSSTPSAIGDLLSPAQRMKTAGEVNAAILESLSQGKEVKLVQLVKLLSWGQGMLKERAAFPKMTLDDGSILGSSSFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1F3</accession>
    <name>A0AA38U1F3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Opioid growth factor receptor conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_338041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1F3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="2">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="253" mass="29452" checksum="7DC0CDEF2CF0E45E" modified="2024-01-24" version="1">MNNLPADIQEFLENYPYGSDDESLSDNLEFYRNRLRCRPDKLLVEQIHEQWIGDYDKLEYKHGFIQWLFPIREHGMNYESQPLQSHEIEALKSDPNAITRIVESYKLMLDFYGMRLVSLETGEVERALPPRDYAARYKNLIRSSHNNLRISRILKCLSEFGLERLNAGFLLHVLSEQSESKELNSPVVRGSMDRWWANCVRNDSERAWIQATISKVRAGNGFVFTRESYQEALKSRLESGHLGDSEEAATDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1H9</accession>
    <name>A0AA38U1H9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_258585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1H9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="435" mass="48864" checksum="1F4A79059634D2AF" modified="2024-01-24" version="1" fragment="single">VSGGGIGGLACAVALKNHSNLKIDLYEQAAQITEIGAGVTIWPRTWEILKSLGLANDLSVLLKEPPSNVQMAFEMRLSDRKEGFTFRKIYTRDGGFCFHRADLQTALLRQIPDFCQIHLSHRLERCEESVNSVKLIFENGFNTSCDMAIGADGIKSVVRKYVSNSEELVFTGSRAFRGLVPRERIERLYPNHRALVNAVMYNGKSKHIVVYPINGGRLINIAAFISHPEDEGKVISDLNVRRANTGEILRAFSEWEPEAIQLLSTIQNPSCWPIQDLRPLKTYTSRRILLLGDAAHAMTPHLGAGAGQAIEDGFVLGYLFDNLMQPNDPECLLRLIKVYDSIRRPFANHLQKSSRKQGYYNELNMPEFDDIHFEGQKLDTQQIIALGSALRESWDSWWQDCALADLKQVLDPSSTNEDLSRVIVLNGNLDHVNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U2R6</accession>
    <name>A0AA38U2R6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_301774</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U2R6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3791038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="96" mass="11065" checksum="0AEB383BE95C623F" modified="2024-01-24" version="1">MLIFSVFKTLTDQQVTVELKNDLSITGVLKSVDQFLNIRLDNITVLDEARHPHMMAVKNCFIRGSVVRYVQLPAEHVDTQLLEDATRREAQNQIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U6V5</accession>
    <name>A0AA38U6V5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_341428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U6V5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="147" mass="16417" checksum="F996E80498867972" modified="2024-01-24" version="1">MQERKETVPLVRDSGKSLLPFSRVQKIIKADREIPIIARDATFLISLATEEFIKRLCQAGHKAAEKERRTTVQHKDIVAVIRRADEFMFLDEIVSLNQPEPQKRIPKALAASNTVTPTSGLTILDSFVQTNSTRTGSEQSQDAKGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K800</accession>
    <name>A0AA38K800_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_336673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793609">
        <property type="protein sequence ID" value="KAJ3781059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K800"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="192" mass="21590" checksum="BDEBD4277FC6806D" modified="2024-01-24" version="1">MDVVITEDTLWMIGNYAFISATTLWIADFIETLPTEINGIWQKKLTGASVLFLINRYSFLLSLMFGIPSSLPENDDNKQLVIDMLEQITSPSSSSAGTQFQSFSACVINVPDSNVYYQCGLDSLYMEFLSNPAIVRFVIPFITLVYDIYIFGLTMRKTIGLVFGMKRQGQSSVAHVIVQDGGLASNYQFFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K885</accession>
    <name>A0AA38K885_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_379501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793554">
        <property type="protein sequence ID" value="KAJ3781479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K885"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50903" checksum="899C1622E4238864" modified="2024-01-24" version="1">MFSRNQLYKTTATLEGCPNAVTSLSFSAEARFIVATGDFGAKVWDTSNMSEVALPSKVTQREPKQPKRAFQVASWMYFSSKIHVLILGSVRGDIYLLSWSNVESAFQVFRALLPCTPGDQGSQVIAMDVFETVVTNKTGYFVTATLDGHVHLRSLTTAGTQTIFLIQLDKSFNLGPVRFGKMRDVYVFGTIGGGIMCLDRATGEIRESHTRGPVPMGTVIIGRSESLFVAGTGQDFQAYRLQDIVYRQTYAGPGRLIAPISKDIVFAEEETILVGGTDSGMAIVYDTQSGKVIQTLQYPRGGLVQSVASCTLKNTCFIAIAGSILDHPSDILIFKKHRKAPTNISGLISYPTFVKLPKTAHPPLPNEFVSPSKDHHAFTPFITAHDDGTVKVSRSSQLHEEYEPSSQFHAEYALVEALSRFHAEYVKASLKGHDDHGVESSTVSAVPRGSRASQTEVASESETIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8T4</accession>
    <name>A0AA38K8T4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_362935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="MU793457">
        <property type="protein sequence ID" value="KAJ3782739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8T4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3782739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="322" mass="35710" checksum="CB1AA3ED3F951851" modified="2024-01-24" version="1">MSALAYLSSARYGKDAVRVFRVVREGSTHTVVEYNVKVLLEGNIDISYTKADNSVIVATDSIKNITYYLAKVSPHILVPERFAVHLGTHIVSKYAHIQKAFVDIEQLRWSRIVVGKDGKAQPHPHSFFRDGEEKRTVKVQIDGTAGKDKIQAHVSAGINDLLVLKSTGSSFTSFIRDEYTLLKEVDDRIFSTSVDLNYTFAPINISPPRDEKKLDIVIPALDQAKSGSVWDSTVLDRARTVTLEVFAEDESASVQATLYKMAEKIIAENADIQTVSYALPNKHYIPVDMSYMGLDNITPAKAEVFQPVDAPSGFITATVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB15</accession>
    <name>A0AA38KB15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_338004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794859">
        <property type="protein sequence ID" value="KAJ3779458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="127" mass="13975" checksum="383539052F2D311E" modified="2024-01-24" version="1" fragment="single">MSTPSNADTPTPPEKENLDPKTPTKKSQKEAKIDTTGMTDKPADDDRVMINELLRQKDEGNATDNGGWKETALQAVVRALIGSENISGGVLKTVQSIRDHYGKLKTDYKNFNTLATQSSWGWDSEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBB3</accession>
    <name>A0AA38KBB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_348451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="268" mass="30817" checksum="0398C7EC2AECB707" modified="2024-01-24" version="1">MLVQIRQFAFSLIRLIETQEHQTDQCKQEKCNTANLICSAGDIHRISPLFSSTFLFYESWSLNLFTMSPFLLQSAIVLYFFTSLLSMTVIVDAGPTAVKRLNPFSELEPRSLPWKGFDPKKPMGVAYLNDENERFVSDDLTPARIFSRHLGNFPTHTQCLVYDENGLFSHPDVPLLYIPEEFTANKAELQKYMQTRHHNLASTVWIQGSTTTEHPTYAMNIPKELWNHKPLRIDCEHPLSDSENLDFDWKSVLRAGGKPMEIMGFHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBE5</accession>
    <name>A0AA38KBE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase, V0 complex, subunit E1/e2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_301306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793963">
        <property type="protein sequence ID" value="KAJ3780043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="71" mass="7747" checksum="25396D75DC043FA0" modified="2024-01-24" version="1">MPSVLPVLFGLVIAVVLMACAAIFTLKGPQQVLIRTSLMLALAACYLMWMVTYFAQLHPLIAPTRSLKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC19</accession>
    <name>A0AA38KC19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_384816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="447" mass="48788" checksum="71DB04D835A6000F" modified="2024-01-24" version="1">MPKDTSPSLPTEEKQPKRPPNAWILFRSDMNRALKLKYPKATQSALSKQISNLWASAIPEVRAEYERRAEAAKVAHHLKYPNYKFNPRKKEEIAREKQARLQAKEERARRNNARNPQRAPVDQSQLPQMPSLYPTLADFGPNGPSPPVSAAGSPQDFSSREASPAQFTPPLTLPDLPPSHVAPSQLQQTFSPLPTANMSLPGPSNWASSSTQYDAPSDFQSSEEPQYNALLQFDLPASQLPIDQSFQQPMIDSSQENMGVALMGTGDSSVFHVNPFDNGIINGQQNLDLNIGVGDFNGLFGMSEWEFNQAMDQSQAQFSENIDFAALFSSLDDTSLVQQNSSYNMGSHMQAESPSYEQNTSRPPSGSYSSYFASTPLESASIEPSALVTNASTSSQVFEQGSASTSSYAPPSGAAYAGNRRVGGSWSQYSFPSEEHSQAYAVPAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC41</accession>
    <name>A0AA38KC41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_92583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC41"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="165" mass="17881" checksum="25FA24702638CD16" modified="2024-01-24" version="1">MFIEPNGAPRAVINSKGRRRRPGTKTLAQALRCNDEDFIDFIAKCLVWDPERRIRPQAALRHPFITASRKPKPPPSSGKSTLSSSTLSGRKKDVMETPKKSLISAPTPLTARSSRITGGVPTTPSTSTHSSTLTSSSRSYRTSQAHSLSSHHSSRTLNGYVAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC48</accession>
    <name>A0AA38KC48_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TAFII55 protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_320754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793597">
        <property type="protein sequence ID" value="KAJ3781138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC48"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="131"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="504" mass="55796" checksum="50ABD920BCE6C9E4" modified="2024-01-24" version="1">MYDDLIIIDDEEPQAGPSYINGSSDADPPTTPIASTSNPSAISGSRTSSRLRASSHAQQHAPRESSFASPAPKTESKNSNISTRSGAQRPKTQPKLKLKLSEKLAAQAPGMSFLGQYDRELDSDDNEDLAFEEQFILRLPPGEDCDRLRKSVAAREVPGDVWFKFKDSRRGVFHIGNNTYASKLVDMPCIIESQKTLDNKQMFKVADICQMLVVEDRIDNEDVVTREKSLNIDDFIWPHGITPPLAHVRKRRFRKRINKRTIETVEQEVERLLEQDNLAKEIKYDILENVNPDLSDSEFIEREEPIDAPTPAISDTGDPATPGGILGDEGEDEDEGDDEPDGDIDEELAAELDLALGDEDDDGDDDDDDDDSDDDDDDDDDDDEVSQARKLLNEEIRDLQAAVAKKGSEIASSANPLIRKRFEDALKKLTSDLEMKLAQRDEMQEKQRMEDEGIVVDNIRGGGDSDSEVEVDGVGIGVGSAQLRGDEDLFGGEDAVMELNQIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCB5</accession>
    <name>A0AA38KCB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_108829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793556">
        <property type="protein sequence ID" value="KAJ3781468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCB5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041440355" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19964" checksum="35655F27DDAB0BF4" modified="2024-01-24" version="1">MPYCYRLITAVAFILSILSSHIVNGVPIAAIDSLVLRSHIPGTTFELSKSQNSTTVSVVYYHKAVATVLTTHAFSKGSQAFVNLSHNIVRGARGARITIDAQIYIRVPILILFIFIMLFLVSLRLTSEDEDEDDSEDFTTVVEKKEPLTGLREEVNNGRYEYCGTAPSGYKEHKPDSPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDJ8</accession>
    <name>A0AA38KDJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_334581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793410">
        <property type="protein sequence ID" value="KAJ3783643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDJ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041270542" evidence="4">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="112"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="269" mass="27986" checksum="3637D4DB5A4F5C5F" modified="2024-01-24" version="1">MMFTAAFLVQALLASAAFAIPTSKERAASRRARRSGATRQSKPLNRITSPTSEISNASYVEFSSNWAGAVLVASTATYKSVTGTFTVPTPKTTGGSGEECATAWVGIDGDTCETAILQTGVDFCVTGTSVSYDGWYEFYPAASFDFSGISFSAGDSVTVTATVISTTEGTLTIENNTKGTTVSKTVSSSAKLCETNAEWIVEDFEECEGSSCELVPFANFGTIEFTGASATTSSGTVTPAGSTLIEIEQSNKVLTTVSQSGSTVTVVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEM7</accession>
    <name>A0AA38KEM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance-associated ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_63462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793442">
        <property type="protein sequence ID" value="KAJ3782996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="848"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="891"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="958"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1078"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="187"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="555"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="853"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1165"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3782996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1444" mass="160032" checksum="F0F109E45E8CED2E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFT5</accession>
    <name>A0AA38KFT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ASST-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_271138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041215898" evidence="2">
        <location>
            <begin position="23"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="559" mass="60338" checksum="68F5FB6BCDC946AF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLF1</accession>
    <name>A0AA38KLF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sorbose reductase sou1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_368775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793666">
        <property type="protein sequence ID" value="KAJ3780720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLF1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37812" checksum="0E0CF7BD9FF590AE" modified="2024-01-24" version="1">MHVAKALRYARNTAWSIRGSAVRPVGCAQSIRSRFFASSPKSCSEREPQSVSALAPIGVEAALQTPINPSSTTPRKIFSEFAIPDRVGIVSGGGRGLGLEMAMALCEAGARAIYCLDIHDKPSEEWEAVREYVGRLKPLEQNSSSNSSSRLEYVKVDVTDQNAVWRSVQEIGDKEGRMDVCIAAAGVLKPEKDVLEYPGEEFSEVMNINVNGVLYTAQAAGQQMRRFGNKGSIILIASMSGSITNHGHAWIAYNTSKSAVLQMTRSMACELGGEGIRVNSLSPGHIYTRMTAQYLDSQPHLFTKWSSLNPLGRLGRADEMRGVVAWLASDASTFCTGSDILVSGGHHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLF7</accession>
    <name>A0AA38KLF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_134746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793661">
        <property type="protein sequence ID" value="KAJ3780750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLF7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="310" mass="34677" checksum="621B8250D7F44A1F" modified="2024-01-24" version="1">MVRGRKRDMSAPLTRSLILQRDYRARKAKYISDLEARCQKLENDNSRLSKEVKELKHQLRQRGMDHKDRFAVTSEADIEKSHALNSVMVSLQSAAASIKSFQCLFMADKPDATHDHLTNKKQGLPSPSTTQSKFSINHDSTGLSPQDFQTVHLYSPVSNAPPSPTHLTPSSRDSITKTWNLELVTQGFPSDANLDGPTSSRARQNSHMRPQSVGSRSDIFPPDPSVDFSSSSSTQSRRVSSSRSFCEHEASARTALASLRERSFNYPIPGYNRLHGLPGHIMNDVLPQDGHPMAFCSYERTFAESLRNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLP3</accession>
    <name>A0AA38KLP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_379835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793596">
        <property type="protein sequence ID" value="KAJ3781140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="400" mass="41702" checksum="D6743B80C2292BA9" modified="2024-01-24" version="1">MDVDADIESTSRRRQPFQQQNVNDTSASQSFRSFRAQPQYRSSDSYSSQLQHSQSFTGGDMFRFNVPDNNGFSYSREREDDPSFSASRPSTATTARPGTSTRPSTATTLPPLASVLPSSVAPLPPPSTSRARPGSNPGFSGRPLSSAGPRGILGGYGNSLPPLGPSGHPLPTLSSSKSTNGLRLPPPTPSGFDLRPGSRGGSSQGTYAFRPGTAPALGPGAASNSNVYAGYGMGFGWEDDRSNGESPFSFNAPPLSSSGSRKRGFSAVDEGDGDERTSESRPQSRRLSVMELCAPENTSGRPESSSGSPRNGGILFTPIRDRESYSSATSGSRPGTSGTGLIVRGAAGLALGDRENGSAHSIPKSHELLARNAPAAGGSTTKNQRENANATGKRSLSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM51</accession>
    <name>A0AA38KM51_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_76378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793463">
        <property type="protein sequence ID" value="KAJ3782639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM51"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3782639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="524" mass="57267" checksum="3C3B238230D7340D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMF5</accession>
    <name>A0AA38KMF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_337845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794454">
        <property type="protein sequence ID" value="KAJ3779646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3779646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="506" mass="57053" checksum="6FDD3BBA61571E78" modified="2024-01-24" version="1" fragment="single">MSRQTTINSGGSLQKTPSERMEENNSVNVFFNSSSTHSVHKATDIKEKAAREFFASKAQFLGNNQLQARDDIYSMLLRATRLPKKDVDTALKAVEHSVTLLKRLDEQKLQEDLMAKVKETIEASLTKTDLSQQLQQQMQQLRTEFNEKLEAMATNIIGTGEKIEKITSDRYQEQRAGTYAEVARTNNQASKMTPQTAAMNRQRMKAHVEVKRRQVLLINTGNEAAKKLDEQGPNEVLTYLNGILIQMGALNKGTFISITKLRDTNNYLTEMSTPTIADWLRNIGQTVQFSICTDEALKIAEKEHEIILHFVPIAFAPDDAHSIRTLEETNDLPACSITRAKWAKPVQKRAEGQRVASLLVYFGNADAANKTLLSGAIICNKRVQAEKTVREERRCFNCQRFGHIAGLCPDGDKTTCERRHCINCGTDDHASADRECPVFRQRCDALNKRAPTNLLPFFPSSEEWTWDDEPGNAPRVGPPPRVTFRTERARQRQTQLSGWGPPRGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMJ8</accession>
    <name>A0AA38KMJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_83542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793484">
        <property type="protein sequence ID" value="KAJ3782325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMJ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041278178" evidence="1">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="220" mass="24703" checksum="47DAEBB3FB77F584" modified="2024-01-24" version="1">MLLPSFDKLAFLTLFSLTNIAIVNVGAMPPRSRPSSSSSSRAHSPVLPGPMFVGYAYEFKASPGKYLHYSTLGTGRVAVYSQPKLDTVEVLEDCRKCLVHDTGFLEESKQRLLFAPLQVGESSDAIINYLREQGFHGDSEAAILVQEDFEGGEVMLIPEKILDGKSTLNIRCPKEDEHDYLMVSNTKEAANWRHLDIKFWAQNSKYLTVDYPNRRPHSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMQ8</accession>
    <name>A0AA38KMQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_381390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794003">
        <property type="protein sequence ID" value="KAJ3779991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072:SF4">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="288" mass="31863" checksum="B61D2C365EE1FFC0" modified="2024-01-24" version="1">MRREISRFLSLTELDDSEKIGTAKTSESCRTRFTTLKKEYKEVKYLRNLSGFGWNPLQHVVTATPSVWSSLLTASPKYAKWQRKSFFFFDEMAELVDGHVATGATAFHPSAPAPQPVPIQDEAEADDEQTDDGEDLAMDMNLARSSQSTITQASQSPRTPVQSSQASSTVSVAIKRRRSAAPDSLERPSKRSHSRKSNQSNAGLEIADALRDLADSAKGDISDPNSRTPSRKSRAIRTIEEDGELSDSSMMQAFQLISRNVSVADTYLAISDVSRRTRYLSAELFSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN03</accession>
    <name>A0AA38KN03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_47478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793410">
        <property type="protein sequence ID" value="KAJ3783629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="50709" checksum="C7B40A6920D58E28" modified="2024-01-24" version="1">MFKSNSGSELPLELVELIIEYTDNDKKTLQAASLVCSIWRTAAFPYLLHDILISEEADFERLKKLCYRFPRLPTYHARSITLRPGTRLSSELSICEALRSFSLTRLFEDRRWELNQIASELPLMPKVTSLKWIMGRDVRHAIIVGPTIHRHIALLPSLQRLTLKARFEDLHELELFLGVCCGGLRSLTFQGIWFRNNSSRPLRLGDTRHLCSLEKLAFERTRASDPAYDEVVDLLLLFMKNQVSLQVLRIRYDFTMSPASLERLLDKSKKTLETLVIEPIGVAELPLWAHSCHPFARLGSQTKSFTLGIPQTTPGGPALTNSAPFEVLDFFRFVHALPPMPHITTVTITFRIYNEWDASEIWGSSTYPERNMKASWHRFLSWLAAQMPSLSLLIFFVKFKTKFNEQDQDRFFGFAKDAVPALRPGIHIQLQWMLEVASMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNL8</accession>
    <name>A0AA38KNL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WLM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_358308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793382">
        <property type="protein sequence ID" value="KAJ3784304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNL8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="WLM" evidence="3">
        <location>
            <begin position="115"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="262" mass="29735" checksum="F021B7095E274F3A" modified="2024-01-24" version="1">MDLTVSHRGQSYSLSILPDDTLAVLHARLEELTSTPAHLQKLLYKGKSSKSLDDQITLTQAGLKDGMKIQMLGTTTKELHEVKAVEDDKQKRERILRERALKGPTKLRSTGSSSSSSNELNYRFHKLIPLSHLPNPSSALDLLQRLSDDPAIRHVMQKHKFAVGVLTELAPHEHPELLGLNVNAGQEIKLRLRTDRYDGFRTYMEVRRVLCHELTHNVWGDHDNNVGFSLLFSTGKSQITRRLQGRTLVYKWLVGTKGVQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNZ7</accession>
    <name>A0AA38KNZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">APC amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_396093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793401">
        <property type="protein sequence ID" value="KAJ3783855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNZ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="553" mass="61005" checksum="61D741CE41783A8C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP69</accession>
    <name>A0AA38KP69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_13985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="680"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1630" mass="178978" checksum="D5539296D01185F2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQF3</accession>
    <name>A0AA38KQF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_361693</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="MU793434">
        <property type="protein sequence ID" value="KAJ3783156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="174"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="550"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3783156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="652" mass="71912" checksum="15A52110C2F852A2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSP0</accession>
    <name>A0AA38KSP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_182581</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3785991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSP0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="16">
        <location>
            <begin position="173"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="14">
        <location>
            <begin position="394"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="551"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="957"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="964"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3785991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="990" mass="112943" checksum="C581F583ABE4B4D4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTE5</accession>
    <name>A0AA38KTE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_279392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793733">
        <property type="protein sequence ID" value="KAJ3780462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626">
        <property type="entry name" value="ZGC:158463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="102" mass="11421" checksum="2BBA81B156550A6E" modified="2024-01-24" version="1" fragment="single">NNRSVMPLDVLGRTRATLTEPASFFPWPEGLGNLVKLCRAGDRALQLLLFNEEYLVSASHQLALITSLPFVHTARRYYRLNGLVRSPDWLRGAGNGTLLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUP6</accession>
    <name>A0AA38KUP6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_285197</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="371"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="447"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="525"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3788946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="868" mass="97987" checksum="E63DFEFDAB1B8B59" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVC0</accession>
    <name>A0AA38KVC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_272743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793403">
        <property type="protein sequence ID" value="KAJ3783807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVC0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18130" checksum="1BC67E72A24FEB9A" modified="2024-01-24" version="1" fragment="single">SVVNYQGSILLDTFVRPTHHVHSLRFLETNIQLSDVANAPVFDEVRNRVASLIQGKIIVGHSLWVFLSIMGLSHSTLETRDLALFRPLRRKLHSSRIVDLPTLVHIYMGRKIGLGTEDSLENARACIDLFRSCEVQFEDVVHVGAWPCDLPPTSYSQYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW40</accession>
    <name>A0AA38KW40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794266">
        <property type="protein sequence ID" value="KAJ3779753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW40"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="217" mass="25071" checksum="038CCA9CA96DBB43" modified="2024-01-24" version="1">MQQHIGHAMQKRSATIVSALESYNEAAAKLSPPRKLLDWNNVLNYTYLSEFDFLRDTRSDVHDRPWAKPAVREAMSEFFKLIRAGKELDRLHIEIKRLLTSMKEEEEYIPAVARKVQAYNPPLAYQIQLYGNERGRFNVVHRMRLNSIRKLKGFNPIDSHFFQPGIGIQRQRVEEADFCETPEAREEDDDNESEGEDEEAEANDLAATVLAIANDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWE1</accession>
    <name>A0AA38KWE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_380919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793821">
        <property type="protein sequence ID" value="KAJ3780263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWE1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="152"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="374" mass="42924" checksum="DDFDA5E938E64C3B" modified="2024-01-24" version="1">MENPTASPSRQSEVDHWVDRMNSASSQQADRYWRNLISENLDLYMSTITERYNFRELESMAKHLSNEFYDLAKLFDIHGDQTIAAVIIEQRSLYCRASLVFLAMCQSLDRSINSWRSTHSQSTCILLSAKLSALKAKDKQYAIPRTAWNDDHIISHDDLDRLEPMKWLNSVLMDVFVSKLNVKFALPVYDQRVAFLDSTFTLHHILPATKSHDTLKNPAGSIRSKPLKALQHRFKDKGITLIFPLNVNNTHWLVGAIFRASSTIGIFDSLIGESSNQAYHKLAYENMKKVWKVLAEAWFKDLHVPDQEWKFVVHTKIPKQGNVSDCGVFAIMYMIHLGYSSQINQEQVPLAYRLPVHSENLAGMRLLLLEELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWF9</accession>
    <name>A0AA38KWF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_279580</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="MU793781">
        <property type="protein sequence ID" value="KAJ3780338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041460160" description="laccase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="159"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="362"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3780338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="520" mass="55547" checksum="81D09F82D161E070" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX14</accession>
    <name>A0AA38KX14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_116015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793578">
        <property type="protein sequence ID" value="KAJ3781283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX14"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041459446" evidence="2">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="168" mass="18836" checksum="324322C3B74E347A" modified="2024-01-24" version="1">MMLVHGPILAILSLLLGLLSTPANAAPLIRSINPIVPRALLHSHLQLRSQESQNIPPPTLPPTHPPFPHADGHSKRGTGATPMTFYDVWFSKTKPEPPARDPIVPSSIQHETYKRIMQLEHSEGPLGLVFLEPYLKSESKFWYQESDQKKSQSHQVDFVTPTERVTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX99</accession>
    <name>A0AA38KX99_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_99875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793534">
        <property type="protein sequence ID" value="KAJ3781673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX99"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="549" mass="58612" checksum="B9050EE61485196A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXZ0</accession>
    <name>A0AA38KXZ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_389637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793458">
        <property type="protein sequence ID" value="KAJ3782708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041400898" evidence="2">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="144" mass="16168" checksum="0CB3DCB8A1CFB911" modified="2024-01-24" version="1">MADSLDCFSLCFCCFCFSICGQSETSSCRWLCPCCHSHRSKFDEDPIMNDAELDAIVERQLYEQRAAWDAANPRSKGLRHPYAPQIPAPATLPSEKDITLEPKGTTQMPSRFVDHNTPLSIPEPMHTQPASYSTMGEDLGPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYQ6</accession>
    <name>A0AA38KYQ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_388630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYQ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="25193" checksum="E33A212971790820" modified="2024-01-24" version="1">MTLHNEPTNQFPQSPSISKKHPRFYFSDGNVVFRIEDTLYRIHRYFFQRDSLVFEAMFSLPVPVGERPEGEAEDRPIRLDGVECRDFDHLLSLMYPKDFGSYELSTIEDWKSVLKLATQWDFDSMRKLAIKHLALIASSADLVILGHQYDVTQWLLPRYIELCVRDETLTLEEGRKLGVDTVVTINLIRNQIRYRSNLNRHKDAIAELVQSVFITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZU4</accession>
    <name>A0AA38KZU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_352054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZU4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="439"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="499" mass="52811" checksum="8953E57E2FCA8576" modified="2024-01-24" version="1">MKLNSPLPQPLPKECAKAAKIFKSFVDSGNNGLDGVIPRHVLENAKGFAIFSVFKAGFLFSARAGSGVVIAKLPDGTWSAPSAIGTAGLGVGGQVGAEMTDFLVVLNSKSAVRSFMAAGSLTLGGNASIAVGPLGRNGEASGSVNSSGKVAAMYSYSKTKGLFGGISIEGSVIVERQDANVQAYQNDSVNAKLLLSGSIEPPPWASTLVKTLEACTGMPGTRTWINDSREDSGYVFGGLASPGAETASTLRKSKKGGENSPYPPASWGEPKNSGSYFESKSSPKPDNDSLYYETNTFDSKSALPSSRSMSMNISRREVDKNYATSNFSTRFESDFSPEEDLRRPNRLSLYTLQKPAADPFESLGNFSTPSSGHGRSMSMASPSLLSSDSRRYSSNPFISSAPLDVSSKMASMSISPSIANSQPYITPKPELAKPLSPHEGVARAIALYNFDGVEFGDLSLKKGDVIIVTKKTASSDDWWTGKIENRKGIFPANFVELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0F5</accession>
    <name>A0AA38L0F5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_347062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0F5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="89"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="364" mass="38868" checksum="1217CA887E17FD0F" modified="2024-01-24" version="1">MENYTSDSFKPLLKRLVETPEYFGSEDLTVALNHLFTPNTLLPEQIGAFLTALHLHRVERRPESLAAAASILRERSLKAAVQETENDFVVDIVGTGGDGHNLFNVSTAAGVVAAGAGARVIKHGSRASTSSSGSADLLQALDCLFVAPSPGVPMPIPRVPFTFILAPHYHPALAFLAPYRKALPFRTMFNILGPLINPARPRGMVLGIAEPELGAAFAQSLRDGGVERALVVCGHERLDEISCAGPTWAWELKDGKILELTLQPELFGLNSHPLSSVAGGKPEENAATFKTLLTSGTDIPERLIPVKDFVCMNASALLVVAGIAADYKEGTRLASESITSGKAWAALETFREAGRQAAESLPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0W1</accession>
    <name>A0AA38L0W1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">GGU10DRAFT_344748</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0W1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 22" id="KW-0408">Iron</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="24">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="25">
        <location>
            <begin position="108"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAJ3788978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="484" mass="53740" checksum="92137C8666D87B59" modified="2024-01-24" version="1">MSWSLQEVSKHNNTKSCWVIIDKKVYDVTDFLQEHPGGSSIILKYAGRDATGAYEPIHPSDALEKNLSPSQHLGPVDNDAVDSLEKAEASKKKTKDELRVEQFMKKRPPLNRIINLADMEDVAKQVLSYRAWAYYCSASDDEISLQENARAFQRFFFRARVMRPVSKCDPSTKVLGFETSLPIFVSGSALAKLGHPLGEVNITKGCAPSKIIQMVSSNASLSYAEIAAARSPSQTLFFQLYKHKNDAIALNRIREIEQLGYKAIFLTVDAVVPSNRERDVRSPWVLDDQETGIKVYNDGEGAADTDPGLGVAGALIVNDDRDMTWEKTIPWLRSVTKLPIVIKGIQCVEDAILAAEAKVDGILLSNHGGRQLEYSLPPLEVLYRLQIQQPHIFDKLEVYIDGGVRRGTDVVKAVCLGAKAVGLGRPFLYAQSAYGEVGVRKIISILEREIITTMRLMGVAKIDELTPDLVERVDWQPVARSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3G0</accession>
    <name>A0AA38L3G0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ROT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein rot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_379381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793542">
        <property type="protein sequence ID" value="KAJ3781600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3G0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041304937" description="Protein ROT1" evidence="11">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="235" mass="25220" checksum="04F193D5E6E72831" modified="2024-01-24" version="1">MAPFTFALAFLLASVPICVHADISVIVGSWSSGSMNVQTGSGFANPAQTSFTYPNTSGISYSFSSQDSTTEGDPWYEIARYRFTSNGSQPNCITAVMNWVHGTYAQADNGSIILTPNGDGYQQIQDPCAAVSNFIENYNDTELLANGYYTFTDPNLGLALQLYAFDGSPLAPMYQVSSTPNMLPTQQLRNVTVATQVIQRRGNGVQSSRRTLANWTLAPTAAVVVLVLAVGSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4L5</accession>
    <name>A0AA38L4L5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_191830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4L5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="172" mass="19273" checksum="50E7FB91C327A10E" modified="2024-01-24" version="1">MEGKIRPEGSQSSSTEVIIQSFEGPRAKQLWQETSPRYLVFDGDCRRDTRLLLASLIYKEDQEITMRGTQVVHAITSALEYLSRNFPGRDIKPEHFNVFSDDQGKTVLSFTPDITALEGGGIGRRETSRGNVSRYVDPNFGLCNSLISKVVKFLFLEGKTDSACCMPRPSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L563</accession>
    <name>A0AA38L563_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_356643</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793362">
        <property type="protein sequence ID" value="KAJ3784825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L563"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3784825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="580" mass="65407" checksum="23F90D3FDB3FF7CE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5J1</accession>
    <name>A0AA38L5J1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_433058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5J1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041458762" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39342" checksum="AF40AE2A94FE0A80" modified="2024-01-24" version="1">MLFRNTLQLVVGLLFVTGINATWEQERAAELGQNMNRPWIIKDLFGNPVCPGSHMNEIVYEKDLTKKLSNMKILSNVGQDSEGVYTFPPGVDYEINGEKVPGDSLVVKLVDPHFDPNSCEVEILRRLGSLRDHGKMWREPDFGSEPKHSPSGSPSDKKAEHGSNSGSDSGSDSVELLDSGVIVMNKVKGRPLIRYEWWVELSKPQKKELVEKTLVDIKNKVYGLLKSERLLYADLELDNLLVEIETDDHGIHSFKEAHLVDFGFPGIFAVRKIPEPEEFDSWFYGQFNYYSADLRKAQNWREFSGTQLAESSEAGKRPSNHDAGTGGTGQAKKQRQRRRRLRMIEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5K2</accession>
    <name>A0AA38L5K2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane proteins 14C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_348508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5K2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="102" mass="10412" checksum="F2EF73AA685D69E9" modified="2024-01-24" version="1">MSAYPSYTMGGLCTVGGITGFVRTRSIPSLVAGVGVGALYLYSADNIRKGANNGLEGALGASVLLLLSSLPRVRKGPIPALLTMSSAASLVYYGNVIYQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5W9</accession>
    <name>A0AA38L5W9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_177971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793322">
        <property type="protein sequence ID" value="KAJ3786115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5W9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="134"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="34166" checksum="CB18DE6A254D8840" modified="2024-01-24" version="1">MNSTSKLTKKQKKGIAFRAGKPGKRKNGVGTDLDNAEDNTVPVLEIQADFDNEDVEMENGTALSEKKITNESSSTQQDKGKGKAIEQETEVTMASANKKRKRSSDLGPKQVKEEGKEEDVPQKKRKGNDEKQRFILFVGNLKYTTSEDTVKHHFSVCDPPPSVRLLTPKASTPSNKSKGCAFLEFTHRNALQQALKLHQSKLDGRAINVELTSGGGGKSEARLQKLKERNKKLHEQRKGRQDKDEDTTHPQRYSATSGVGTAPNAKNTWTIDDTEDGTVHRGGKKHIKKHGRSQRSKDWSTGVNAIPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBF3</accession>
    <name>A0AA38NBF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_380117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793637">
        <property type="protein sequence ID" value="KAJ3780871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBF3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23422">
        <property type="entry name" value="beta-trefoil_Ricin_MPL_CNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="282" mass="31486" checksum="37A9E6B36E2EC4C5" modified="2024-01-24" version="1">MNPHCLKPGTYRLINLQSHTALDLSEGDGRTLIGWTQHNKPNQQFIFTPLGHGGGYLIQNAWNSNYVTVEDGICTGISVVGSGFPATWVVEEIDHGKHDITGLTGNCFRIRWPNSRYVVDMEGYGCDKDGTRIQLAYEQYPVHPCQVWRFEEVESSVALLTRDIGHDFTGDLSNSQSDSESDWEGSGQDGDNDIDSENDSDDEFHDASEDGLEISLLQVELPNSRDAEHHLGMTTGDVIWRAVENDSERCKTNLRKTWSTSTTMTTTTVFAASRKNLLEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCL6</accession>
    <name>A0AA38NCL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_357816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041337225" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="172" mass="18143" checksum="E4587DDB2ED636AD" modified="2024-01-24" version="1" fragment="single">MRFNTSLIVLGLAAAVSAVPVAGPPAPEVKTQSTPNEAGIATEPANNLTARDFGIEVGSAGLNRRDYEVSVTFKREGGINPTDETEKKAEAMVEATLKNAAKKLKMGEGSELRVTFTNKWPSAFLQKVDFTFEDPVCGSGATCDGEATPEGKGTIKGGAKKRKNAAVLWTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND89</accession>
    <name>A0AA38ND89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_173350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="273" mass="27767" checksum="CDD024DEF3D41B35" modified="2024-01-24" version="1">MADARSYGSCYTTYVRCTRVNMYMSGVYIYIFRAPTFSNPTGYLYSLWNLDAFADYCRRLTAPTKKKLETRRPMMTVFSKLQLVLAFAALSLSTAAAVAQGSLESESTTSAPPLVTATSIAVVTAVQTSFTIVPGSSITSTDLITSISHPPESSDSITVATPSVTISSVSRTNANSTPTSLAVASTSPSSTVSLSVGSGANKGVVPVSSGFVVTVTSSTNAVESATASTGSGSGSALGAASNGAFGVYGSVPRLSAVVVVLSTLLGGAIAIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDE0</accession>
    <name>A0AA38NDE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_350616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDE0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="372" mass="42075" checksum="DAB7994D5192982A" modified="2024-01-24" version="1">MRFPPFPRSPQMCVPSNVLSSKNILQTSNPVTESDFLSLFSSVTLYGLTSLGDEECSITLTREQSFPAKRYSADEEGRAPVGEQQWDAVSPPVDGLHADLQITDKLGEGRMGQVFAARLVSLKKSIHGETLPDGYIPLPSQFCIKLAKPEYIRSLAREAWFYEQLSKEGYLGAITPVCFGFFACQLPDNVQVLSWSSIKIKPEKPEDVPEGEEPNYDLLVDDEEGWYCYFDDGRRSHLDSPWHLQQWKARTDRSLSVGILITERLGKHMPATFSTPRKELVRGLPQEVRTEMLTLLEDLNVVGIVHGDIKFDNVLNRASESWSSCEVCPRHKRVHPWRLIDFDRAGKYDPVNPVDSSFVSNVQNCAVNYMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDG1</accession>
    <name>A0AA38NDG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_265796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDG1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041361149" evidence="2">
        <location>
            <begin position="22"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="571" mass="64300" checksum="6F1BEC5156361C1C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDG8</accession>
    <name>A0AA38NDG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_386063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="753" mass="84165" checksum="D6C83F3C9B9CBC13" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDR5</accession>
    <name>A0AA38NDR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_414998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDR5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041303652" evidence="2">
        <location>
            <begin position="25"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="410" mass="45400" checksum="C9DD147243C20EE3" modified="2024-01-24" version="1">MLPALSLARPSLLILPLFLSLASTALIASSLGAVQFHDNDREAWFTFMERKFEEGSIPPESWTSYAIQEGLNSSPELQSVMNDRLNQYLRLSSQVPVSTGAVADVSLFGTASWPWEGFKDDISRISDAAKKMSVKDELESEAILDDIPLPEDIHISLPTIKIGDIDITLPNISLPAPAKILEHTLELIEQTKTDFERIFHNELSQVEEILRSIENIVAIQIAKLPREIRQAIEEFDRFRAEHPYVVAGISVALVIIGTEVILPELFMTVLNWFGFGKMGPIAGSWAAALQSTLYGGKTSGIFSILQRVAMSAKRVWPVAVFVDLVAVAVGTITVLSSHLIKQLVDTWYPELEVPDLNLVVQDTNGATDVLFDNFMKGLGKRCEEAGIPEVQWLDMAIESIAKAVREMIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDV3</accession>
    <name>A0AA38NDV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_432649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDV3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="211" mass="23522" checksum="4C5305F520A4793B" modified="2024-01-24" version="1">MCRSAHSLIFKDPRTNDGSWTGTACHHHGKSNQLDSQLPSKSHPINKFRTNKSVVLNGAEAMTRTGLELDSQSRNETAARLISRRAQGIRGVEKFFLFSGRPHLKEVPVVSLVIILQQQIIILTVPIAASAKPSLTAAKILTFFIPKAGWIWRGLRTLSKNEKEAAGGALEARKGAQCPNADELLLSLRVPHQLMPQKRRQNRFGFWRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDX3</accession>
    <name>A0AA38NDX3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_263427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="306" mass="34274" checksum="8DF9D9F88D9B2C68" modified="2024-01-24" version="1">MDNAESSRSKRLSLAGQSTLSVSSLHSTALEICEIVYGEHATSYDAVERFYEASASKQYENPLVTTTSRTMLTDILRISRQLSVINLPRPLAVIYSFFRLQAPDHLSSPWVHALRAWTEIDDISETESFDGHRKTIVEHALNVLIFPDIHTDTGTTARFNQYTESAPPTPSFQSPSHPIHPSLPVPGTSFTVPSPFHLKLRIITRFSFNEQGRITHHRDFWDVKDVMGLVPGVSLAQWIGTRLTARGLSYASRAWFRTSQLQSSATETDAEIRELENGRGLSSSPAVEYARSIQKEFADSTLSNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI34</accession>
    <name>A0AA38NI34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_72474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793453">
        <property type="protein sequence ID" value="KAJ3782792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI34"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="51107" checksum="7AAA2EAD02D7EA91" modified="2024-01-24" version="1">MVKHMGNLPLEALGFSPSLEANFIRDPASLMKLEKPAAEEFPSSRILSSLEGSFFTFPYQNNQTRTVRLKRVIFRSNGVIGRGTMVIRVTCACRHCPRDACDWQAKKLVLKLSFPSATRVSELIFMDRCKQLAQGEHAWVMNHLPDITWSFDIPFRTDSPQDALSNEFGATYEKRVMRGVIQEELKPLSYLQTAKQCAQVFYDVFQCHHWVWKYPKILHRDISQGNIMVREKNGTIYGVLNDWDLATWLNDDRDGPTSLFRTGTKPYMAHEQQSVRWKGPHRYRHDMESMFYVMLLFACLYSSPKEKVPNFEDKDFRLEEWHRKDDEFLRRTKKSLVHDSPFGPPVSPFFIGFRLWLIQLQKRLRKGLNDMGDLDIEAATQEASQSDTLPTFNMETLGGQFSCEQIGMILHMFNNEQLTTRGLEWQNILEGLSRKTQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIM6</accession>
    <name>A0AA38NIM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_358696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIM6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="279" mass="31988" checksum="58CB1DEC3A18902F" modified="2024-01-24" version="1">MDLSDVRASGNSQTALLLVYTDKGAEILETKFNEWYDEEHIPRLLLFPGCTRASRYRAIDSKPPPWTALYHLDSPEIPESREWYQLNEQASDNEKTILGSIPIVTRSIYTMFHGSHAKDIPHHSAGKVACIVHLQIKSRDFDVLLDSSREQADLEAKFKLWHRNFITRGVSTTPGWVRSTMYTRYSGSDMRTTPELKIAMDCQLLVIHEWDENGDAMEISKLEANVAAQVQIWEKENLCDLVSLDDHRSWLIFSDNRSVYFSGVSYLCCHGRCDSLIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIS5</accession>
    <name>A0AA38NIS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_357771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIS5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="264" mass="28424" checksum="0E1C2A32242E5F65" modified="2024-01-24" version="1">MDAFVAEVKKIPPVTRFLSISLISVTGTVLMKLVSPYKVLFHHSLVSGARGFEVWRLWSSFFLGSGGLSFIFEIVMLYRTGNELESGPYLRKSSDFAFQLVIACAAIIVTSVPLSSTLFFRPLLLCLVYLSSQLAPPGAQTSLYGLITIPVKYFPFALLGMDLLSGGPRAAALALPGAVIGHLWWWGVFGSEPGGRGGTMAQYGRAPRWLARWFGETSESGANAGSVRATGSGVHVIPPRARAEEGAPTTHGHRWGPGQRLGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIU1</accession>
    <name>A0AA38NIU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_26996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793373">
        <property type="protein sequence ID" value="KAJ3784517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF218">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="515" mass="57958" checksum="AA61ECC2AAD8B3A8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ21</accession>
    <name>A0AA38NJ21_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_391112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793668">
        <property type="protein sequence ID" value="KAJ3780708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ21"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="273" mass="31295" checksum="0E899304A8B47526" modified="2024-01-24" version="1">MGRGGNSEVSCFRCGQLGHWARECPLRPGPPPSGSSRRNNAPLIDRLDRVQRCHLPPRSPPRMSPPRDARDAPSSRYDYPSSRDYRRPLSPPSRDYNPPPPRTRYDDYPRERDRYVPAPALSDHRSSSSRCPEPAYRGATPPSPYAYDRSDRYNRDSKYVSYAPPPPPPVLPLARPRTPPKYRNDYPPSREYDYRDRGKPATPPRYSEYPPHRVMTPERYSRRSASPPPRSSAVYDYPPGSQSRNYASTPPGPPLSLITQSVIPSQFHRNRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJD7</accession>
    <name>A0AA38NJD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_437370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793570">
        <property type="protein sequence ID" value="KAJ3781353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3781353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="21952" checksum="AA13AF6158F3AF6B" modified="2024-01-24" version="1">MTIYYSLTFLLLATEMVTFTTLVIPFPFAVRKRVFTFLSESPIVAKIAYGIKISFIFVGILFFDALQRMFRITAESDMAKNNQQGMGVGDVRTETSFAARKFYAQRNVYLTGFTLFLSLVLTRTFAISLDLIHSQEEYAKLKKASPSSGSDVEKKAREYDSLKAKFDSQTKEYNQLADKYNKVTTGKADKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJF9</accession>
    <name>A0AA38NJF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_278879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793666">
        <property type="protein sequence ID" value="KAJ3780724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="49" mass="5866" checksum="18E5640C12D4AB0F" modified="2024-01-24" version="1" fragment="single">RAYHRDGVCLVRFLAWLEDKLNQGYDVTEWEAAHRLTEFRRKAVFSSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJV9</accession>
    <name>A0AA38NJV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_429919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793545">
        <property type="protein sequence ID" value="KAJ3781564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJV9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="439"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="644"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="879"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3781564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="915" mass="101831" checksum="D5E5EC06269E8FF1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJY7</accession>
    <name>A0AA38NJY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_310980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="586" mass="63927" checksum="6278B8C03D11ABD3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK91</accession>
    <name>A0AA38NK91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_318064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793457">
        <property type="protein sequence ID" value="KAJ3782733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK91"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="737"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="788" mass="87010" checksum="9643029EF1348A3A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKA6</accession>
    <name>A0AA38NKA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_84179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793490">
        <property type="protein sequence ID" value="KAJ3782224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKA6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3782224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="320" mass="36409" checksum="61D84FFA54E8AA62" modified="2024-01-24" version="1">MPNHSRIIYKTLDSSSWTQENESAILAPYTYLTSAPSKETLRHLANALNDWLKVESTQLELIIKIAQALQNDSLLFDDIEDGSELRRGQPVANSVYGLPQTVNAASYIVIMVYKDALELHAIMNKTNFIPGSTPVEIITEELLNAHRGQGMDILWRDHVRCPSEDEYIDMIKNKTASLFRILMRLMMACATERKDVNFIPLIDLIGVMYQIRDDYSNLRDASYSDTKGFAEDLTEGKFSFPLVHAIRADESNTQLLDIIRQRPKSPALKGQALSYMESETRSFDYTLAVLRALQGRIAEEMEMLGENPMLEKLLSRLRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKN7</accession>
    <name>A0AA38NKN7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_142790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKN7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1128" mass="117793" checksum="5C7710EB7335890F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKV8</accession>
    <name>A0AA38NKV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_331201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="279" mass="31533" checksum="6FEE86D3DA86061E" modified="2024-01-24" version="1">MLEPSNIPMLQSPKFSSLGNLYRLREHLPYGQSTPPNLPSPSSHPTSYFRQRQQRPQKNESRCLQYVMPGLFMAFEDDSISFSTSMNSRLPAEEELRTPDGQTFTHIIKLTTSKNPSGSPDITYTVDSHKTQVLNLDVFSNSHNLFELRMRILASETDCDGLSPEVARRLYTEYGDISEPYEGIPLLTPKQLLASREFMCATGYDLRRRQGAQILITAPRDHCTDIVSVLVCYLAYASRSTVAMVLLEIDRHPEFLGIWKNTVSGHGVSMIQDVVNVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL08</accession>
    <name>A0AA38NL08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_359638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU793399">
        <property type="protein sequence ID" value="KAJ3783903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL08"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000124">
        <property type="entry name" value="Exported cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041411851" description="cellulase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3783903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="416" mass="43525" checksum="4AB9176A080B80D3" modified="2024-01-24" version="1">MPSRRLSALAFALSAAVSVHGQSPEWGQCGGTGWTGSTTCVAGTVCTEYSSSYSQCVPSTTTVTPTSTAPVSTPSITPVSGNTLTYTGVNIAGFDFGCGSDGTCNPTGAWPPLTQYYGMDGAGQMQHFTSTDGYNVFRLPVGWQFLTNGVLGGDLDAANLAEYDALVQTCLATGASCIIDIHNYARWNGLIIGQGGPTNDQFAALWTSIATKYADEENIIFGVMNEPHDIPDINLWAGSVQAAVTAIRNAGATKQLILLPGNNWTSAETFVSNGSGPALLTVTNPDGSTTGLIFDVHKYLDSDNSGTNEECVTNNIDSSWAPLATWLRENGRQAFNTETGGGNVASCVEYMCQQIAFQAQNSDVFLGYVGWAAGNFYPTYVLGEAPTQSGTTWTDTLLVASCMAPIAGAQAGSTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL36</accession>
    <name>A0AA38NL36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_412858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL36"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="481" mass="54697" checksum="97AE9D32DEAEDEF4" modified="2024-01-24" version="1">MLSTQLSRRTSRVLTAVERPLSSTYSPTLTKNACTSRPFSFYHCHSLHTRDCERRALPRTKVFLAHERQYGLSSLHDLHSAFRISSSICIGNSVFPIRRRYTSGTTTQPENSAIDSETATGDDMDIYTAQTILSILDRAKQVWPPPKTSIPPGWSADWDCWDMLFTLYWMSPQYLMLPQIETIFNVHFGIRGETRPIVYSTPDLRMNPSSNEGEEGENRDYKAFVFTVVERPDEFYLLEYHDRPALFKMSLPESPSQNHQQMTESLLVELLASPNKLAFERIEPSPEGSAALQRILARDRTVIPALEQFLGYIPEHTELWEENPQTPYPEQTTESTDKSESLEESKEDKQIAEMKRLVQEIEARSPEFKEASQALNEGLLNASSSLSDDEVDFDSLEHSINAIGLKDEMAELESMMDSADGEMRKFDETLQKSFSSSDSASPDLESFGSLKVEVDEADDDHVKLSVPFQEEEEDRKNSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL67</accession>
    <name>A0AA38NL67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_34185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793385">
        <property type="protein sequence ID" value="KAJ3784233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL67"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="765" mass="84519" checksum="DD5AFBBA9BCCF14F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLH3</accession>
    <name>A0AA38NLH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_345134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041208112" evidence="10">
        <location>
            <begin position="27"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="23045" checksum="9744CB5D8B73E034" modified="2024-01-24" version="1">MPLFLLQRLIASWLVLLLTAQYFAYAHMIDVPAGKKECFFEDLHKQDKMTVTYQVGGGGHLDIDFWLADPEGRLLGKQVKQSTGTLSVTAEKNGRFEYCFSNQMSAIADKIVSFNVHGIIYVGEDDVVAPIEREIRLLAHGLAAVKDEQEYIVVREKTHRNTAESTNDRVKWWSVLQAVVLFAVVGWQVYYLKSFFEVKRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLI6</accession>
    <name>A0AA38NLI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_344912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLI6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="334" mass="37950" checksum="4D85A05A0A76729E" modified="2024-01-24" version="1">MQVVIQTFLWVLYLFYISFGADISIKQASQSSGRILQHRHRSFPASHASRTSTFVRNPRRSLFRDPPSSFRRSTEMRHYSDAHCTVDYSTYKAPSVDRMPFSNPNQYTHNAPTANTLTNYPSNDLTQELSPLEDFRPLQPDFEYNTDTEYQKQLSEMNFGSPFGSFAHHSTGYGHTSYYATAYRETEVGVLEEFWRKVSGDIATSTTTAKPELFSSQSDEHGAWQQPTWTQANLAPYNQSTTASSLEPHAMSMEVENGISPDMAPTQRSHDVAVYSFNQGSEYPCDGQYDHGVLPDPQQTYVAHFFSPVLDNELDPSLLPGSLNHHYPYFNSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMC5</accession>
    <name>A0AA38NMC5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Heat-shock protein 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_311570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMC5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="674"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="700" mass="79531" checksum="9DF4A5714A8E7452" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMH2</accession>
    <name>A0AA38NMH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_266214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23734" checksum="1BE8D48E1FC8E30E" modified="2024-01-24" version="1">MSEQQPLLQPDTEALQSSIPSSLSSRERLSGWLESPYFHKVVIALITIDAAIVLTDLGYTLLSPNCTQEGPEGPEWLEVLTHISLGITAFFLLEIPLALLAFGLEYYNPFGAVPHAILHDFDAVIIVTTFILEVFLKGKQRELAGLLIVLRLWRLVKLVGGIAVGAGELEEDTAKEFAELSRELENTKRDLSDAKEENEKLRSRLAHLGQSENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN30</accession>
    <name>A0AA38NN30_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_432638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN30"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041239433" evidence="3">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="285" mass="30204" checksum="292EBBF1F3584E6C" modified="2024-01-24" version="1">MFSLTLAAATIALSAISVSARVNPRHRLLPRLTTPSTYDTAILEDYFTYHARYLALGCQYNHGNDFFDACCHPLLQNETLSDLESRCTPDPGVLSSVSSSLEGFTSTSSSWSWSSTVDATSTTDAAQTTQAPAENVAASTTTTWSSSSDTWTSSSDTWTSSTDTWTSSSDTWTSTSSATSPASTSNVFTGGFGTYFYQNGVAGACGTVHSDYDFVLAMDSAIYSSDLCGKSVTITNTDTGASVTAVIADECPTCDNANSIDMSLGAFLTIGALVTGQLNIEWYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNC3</accession>
    <name>A0AA38NNC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_384943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNC3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="273" mass="29906" checksum="77DB643597AC8443" modified="2024-01-24" version="1">MTAAGHPSRNETDFNGILLAPAPWKLKARMWHFLVSPLKANTVNGKSNAVFPAGWAAPFQAEPLAEGEFVTGHPGVIMLVQYTDTPVGPYDELIYIAEELAEFKYTRHSDGSWDLAVFPSNPLISETLETPAEVRRPNIPFFHISIHPIPILGSLCIPINFNILGSYFRLLDPPIPNGPPGSSPALVKSNTNSDGSIKEPKWASLVPGIKGKMRLVTYKPKVDVGSDLEGEDRRKRKAHLAIADGVNFPAVVPWKMGACLEGVDIHFDAPEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNL3</accession>
    <name>A0AA38NNL3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_345934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNL3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="290" mass="31845" checksum="8A9210F8EAEC0A1A" modified="2024-01-24" version="1">MDVDPLADNAPPRYAIESDEEDEYNPLQESSSEILSLPETKVIGDIPLDCPLILASGNGGKYWAKGCSLGKQTGAVYVDETQVGLVYHPSWSRSNIIVSETFARLPVAYMHSYAEKLVKELKPSSVVLLDTYPTPTYVLPQPISLQDAPIRYLSTHQVDPIIASLAKRFSPPNFVHSTTSAALLSHVASSVAPSNSDSELKATLLLLPFPRIPAPAPKILGRSDFSHLSEDEYQWSRDTMNTIHKLLFVAVGERLDDSASWHMPVNRSGSRSSDDVPVRAKPLVDDGMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNV4</accession>
    <name>A0AA38NNV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_366258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793541">
        <property type="protein sequence ID" value="KAJ3781610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNV4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="282" mass="30777" checksum="20D1339BE14FE344" modified="2024-01-24" version="1">MTGTVELYFPPPHSEQLLVSFPAEHVMMLTLNRPQSRNAMTLQMQKDLETLLDWFSEESALWVVILTGAGKLFCAGADLIEWNKDQQSGKSEEQERVASSRNGFGSISRRQLIKPIIAAVNGGAHGGGTEIVLNCDIVVAGEDAKFALPEVKRGVVAAAGGIPRISQISGHHFAAEMLLTGKVVSAIDAHERFHFVNVVVRPSEVVSEAIRVAKSIVANSPDAVQCTKRALLLSQSYNLEEAFMRSTFSSESTRVYKGENIKEGLKAFTEKRSPAWKSPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNZ3</accession>
    <name>A0AA38NNZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_409071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793493">
        <property type="protein sequence ID" value="KAJ3782195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNZ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59641" checksum="CC6989271FC74BBD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPR8</accession>
    <name>A0AA38NPR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_352191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPR8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="348"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="708" mass="78327" checksum="07B45C7605E0A286" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPZ6</accession>
    <name>A0AA38NPZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_415920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPZ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="327" mass="35872" checksum="7B2BADCE111BC415" modified="2024-01-24" version="1">MVRGRKKDMTIPVSRTIALQRDYRERKAKYVTDLEDKCKLLEEQNVRLIEEVKELRRIMGQREHIPESGMDLLNCRAEVKKEAFGDIMKTLSAAMTSIENFQHLAEGQSHLPLFNSSSSTPPDSVTSPSSLSSGVSSSSPSYSAYRVQPLNCTRSVNGTSSFSPSVDGYSSNHPNATPSPSPSFSDTAGSQSNYQQTGSASDTPFPASSYWNQTSSPSINYFTSAKQHLRHTQPELLPQDRMNSDLALEDAAKALSNLSSNVLSSHPPFQRTSAMYTTPVSNDSFGGYAHNMVPPGQSSRMRSNVYGCDYRMPARISSGEPYLPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ00</accession>
    <name>A0AA38NQ00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_308907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ00"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12573">
        <property type="entry name" value="AT09986P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12573:SF4">
        <property type="entry name" value="AT09986P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="244"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="479"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="587"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="74913" checksum="6A5EA504FAB367F6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ73</accession>
    <name>A0AA38NQ73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="8" type="ORF">GGU10DRAFT_345711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ73"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="636"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="832"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="901" mass="100280" checksum="FECC6F90B5848DEF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQB3</accession>
    <name>A0AA38NQB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_372364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041395198" evidence="1">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="256" mass="27377" checksum="B84D587621E45F09" modified="2024-01-24" version="1">MKFSFPLLCLPLLASVAQPAACAAVESVPSNKLEPRSSQTQLSSGSAITYGKISSSLSWQASGPLYHGCNLNGVGISDCYQFTLSSDPTKNLEDYSSSSPRQRTEFLTPSAAAGTTHRYRWSYFLQSPVGTSTHFFHLMQLFSRDDGGPILTLDAINGVIAIKDNYRDCSKTGCPSIPLSAFTDKTTIHDVTVSYGPTNGSFKYVVTDSATSNILLSYSATGNMGGNASIKFGTYRLAISNMKPSVAAIGDFKVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQC7</accession>
    <name>A0AA38NQC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_305622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="175" mass="19136" checksum="74CE2CFD2F6003BF" modified="2024-01-24" version="1">MSIAKASSLSRCLQINVTRNALTHSHRRLLMTTSSLRNETANVGTPAVQKKPIGGFRGGIVGFLFGFSLASSFAAYQLLDEYKQASAALQASVEELKLSTQQVTTQVRRIEAVEKDLKALSDASASKEDISRARAEMKKLYNGLNVELLDFRTHVSGIQQDVHALTQKNATSVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQQ7</accession>
    <name>A0AA38NQQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_343504</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="431"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="620"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="107"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3789362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1070" mass="122044" checksum="B4471A1EE1A6754F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQV9</accession>
    <name>A0AA38NQV9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_48949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQV9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="490" mass="55922" checksum="F0F258FE81330538" modified="2024-01-24" version="1">MDVLSTTKDAIELVVLLYERYSDYKESDKTIKSIYTRLDGVQVRLELFEEYIFTAKSNLRFRQVKILFKSLENITDILHELLERLPASINVSKKIAWAAWGKRRVERLLSDLAAWDEETYRTIFTLDMLSQIRGQDSLYQRLFDTGDHSLTATWSLSRRIHSSDDALPNLPISLSDIDITYESSTNLSDRFLSTLNSKLVYLEAHYVTNGEKSQKQAIERIAGVFRSPDLPSMHLLSCLGFAENYVSLGRCFLVYQVPGPDAETGKAEGVPTLASALDREVRMSLEDRFRVATEITMAVMEIHAAGWVHKNIRSDNILLFIDEGKKGTKRDARIGTAYLVGFEAARPQVQISDQRPESDLVKRRYHHPDRQGGQDTMVEKFDIRYDMYSLGAVLIEIGYRKTLRRIFAARGNQQEEPLPGEAEENHKRLVDYGHRLGDKMGSKYANAALTCLTKSTQKGKTTVVLREEFYDDVLLPLKQILEGFQVKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRN6</accession>
    <name>A0AA38NRN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_400039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041487848" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="365" mass="37709" checksum="49730730D430767E" modified="2024-01-24" version="1">MYRLALLPALSLLLSPLVNAATQQLVQVTADIGPNPNDVGMFVYKPAKLASPLPLIVAIHECTASATIYFESTQYATLADEYGFLVVYPNSPRSGSCFDVNTPQTLTHNGGGDSQGIASMVTYSIATYGVDPSLVYVTGTSSGAMMTNVMAGSYPELFQAASVYSGVAFGCFAGASSWNTQCAEGELIQTPQQWGQEVSNAYPGYTGSRPKMMLWHGTADETLLYPNYGEEIKQWTDVFGLSQTPTTTTQNDPQSGYTMTTYGTEVVGYSAAGVGHTVPVHETIDLAWFGITGSTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAAEWGQCGGIGWTGPTTCASGTTCTASNAYYSQCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS17</accession>
    <name>A0AA38NS17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GGU10DRAFT_303713</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS17"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="20">
        <location>
            <begin position="218"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="354"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3790040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="401" mass="45600" checksum="A789F6EBBCE35A1A" modified="2024-01-24" version="1">MVWTRILKCSTPFCASRSPRYFILTSSLHGQIIKHVTRFADGTRPISNGSLENSKVEHSQFLANASTHSKWRDATPGNGTSDAEDDELGGVEEGVGKLLPTTSHLFKLILPLGRKGPNNSVIPTVLLLHPSQPLSHTSRLILASLPRRSETAISVSFRSSSPHHHRELEWSDSTDIGDFIRDAARASEFSIHFIPESDTAEGSKEDEQSISVRVPTFADRTRFLRRRLDVINHQLSEMEGLKRECDREARKGARRMAVGGFGMLVVYWAAVARLTFWDYGWDVMEPITYLSGLSTVICGYLWFLYQGREVSYSSVLDRSVSSRREALYKQRGLDIEKWMELVSEKRHLMREIGQIKEDYEQPQGEESKRNKAIDESEDDDQENKHPLDEPEEEKEKPQKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSD3</accession>
    <name>A0AA38NSD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_178810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSD3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041245945" description="Zn(2)-C6 fungal-type domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="499" mass="55154" checksum="4328134B3D2EACBF" modified="2024-01-24" version="1">MKEHHMPFLILLIIQLQHHALKLIPMGMLAILKMKMPIHKVLQKRKDDGRLSVVPSICTTDCKECKRRKIKCDRNQPCAPCTRRGEQAKCQWHVVEHVEKYVSRAEYDELKLRFEHLENTVHRLMGINPGEIRSAGAPLAIPAAAGPDYQPGNQGPSTGYGIVGTIGEQPFPSSQNIAGAIRSNAPTHHSTTSLDTKRSPSQQMMLPPKFLNQPSTTSAYESGSHQQEPVGPSSPSTPLFSSRRSQTHARQSSRSSVGSVGSMRSPIIPHSSSGMSGANSPVQQYRTLPNESPLLTAASPSIMKNSPLSLAAITSPFDREPGLSSRSGVDPSDSEVLTSTSSTSSSLIPQSKVSISPTFSQPKNFYAQTLWLGERLRKLTLVIPLRHKPRTFLLYITNILFTLLMLHALMTHISTHHFLPAQFITAVLSVVKSTSLIAALVPQGQTEEGSVTLHHLRYYLPKQRWFMPNHPEQAIPGYLKAWSLTRSRQASILYLLLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSI3</accession>
    <name>A0AA38NSI3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">F420H2 dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_341151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSI3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="270" mass="30943" checksum="86EF923538DDBFFB" modified="2024-01-24" version="1">MLSRIAVRPAQAFRAASALSSVRRARFIHGSSPFKASASPFTEPTSPNPAVERYAQAAESLHTYGSYLMQCLPKFIQQFSVLRDELTLYTAPSGIIPVLTFLRDHSQCQFKSVMDISGVDFPEREKRFEVVYHMLSVRFAGRLRVKTYAGEGDHVPSAVEIFRGADWYEREAWDLFGIFFSGHPDLRRILTDYGFEGHPLRKDFPLTGYTEVRYDEERKRVVYEPLQLTQAFRNFESLSPWEQVGHGIKPNRPDELKPLPPPKAELEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NST1</accession>
    <name>A0AA38NST1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_340785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NST1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="315" mass="35527" checksum="592AE0121A8A4F77" modified="2024-01-24" version="1" fragment="single">MTWSWSPFALMLTMGVQIPRSRLPRRSLEVWILQTALLSILASTLMVSTCHASPILAQPQPHHESHLTVLDSTNLISKGLFDDYDSHQDVPAVVGELHAVDTRHLHHRGLGLRKKASQLSLAFDGMTLIGFAYTEALIGKEFDSRPIRLNSLTLPARRPTHPSTEYLYLIPKLGIESQNPKEAFWNCPVYASKSLMKENIPRMVYESHGEPPVYTATFDDGSDGPAPPYTATARNARTTSTAISKRETDRGRIIFFKDQGQSTVIMRLPREEFTQKWGLKGECYRTPNRLPTSAADQWNAWKKNIEGWPSFIDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT18</accession>
    <name>A0AA38NT18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_159310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT18"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041229766" description="Peptide hydrolase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="175"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="388" mass="43071" checksum="79DFAF8AA5D04597" modified="2024-01-24" version="1">MKLSIVLSLASLAFTAPPSLDKFEQQPLTVQDGFDLDLNAQRLIQLAEGQASEWVTEGRKIELKALGLKFFDITDNQDLGNGIQSPARVKSSFPPPNATEKVIPILKTLSTQGPKENLEKFTSFRTRYYRSDTGRASQKWLLSRISEITAKTASASLQKLITFREFKHSWGQNSVIVRIQGSSTTDDGIVIVGAHQDSTNLWPFLPAPGADDDGSGSVTILESYRALLAADYRPVRTIEFHWYSAEEGGLLGSQAVAQDYAANSVNVIAMSQFDMTAWVKRGTREEAGIIIDYVDPDLTNFNMQLVDLYMDIPFVQTQCGYACSDHASWRKAGYPSTFTIESSFENSNKNIHSVNDRIDVSEEFSFEHMLEFSKLAVAFAVELGGYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT53</accession>
    <name>A0AA38NT53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinanase/levansucrase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_416277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT53"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055240">
        <property type="entry name" value="CBM13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CBM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22704">
        <property type="entry name" value="CBM13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041448438" evidence="5">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="6">
        <location>
            <begin position="319"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="444" mass="47553" checksum="A2FFD5BEF058BF3A" modified="2024-01-24" version="1">MTVLWLFPLLAATLLTQAAVIVPGASWTDTEGNVIQAHGGGFLKVDSTYYWFGEDKVLDSTLFHAVSCYTSTDLETWTRQNDALSPISGTMISTSDVVERPKVIFNTKNSEYVMWFHSDTSNYGAAMVGVATANTPCGPYTYKGSWKPLGADSRDEGLFLDGTAYLLYASDNNQNFKISMLDTNYYNVTEEVSVLTGATLEAPGVIKRDNVYYLIASHTSGWDPNPNKVFTASSLAGPWSSQVDIAPEDTNTFYSQNAYDMPLGTNGIYMGDRWDVSALGSSTYIWFPLSWASGLPVIVQADVWSVNLAAGMYTVATGTTYEAESGTLGGSAELLTDSSYSGGKAVGYLGNGGTLTINNIVGIGEAQWVSLYYANGDSTWRNTTLSINGGANVVIQQPSSGGGHVIQSVPVKVNLKDGANTLTFSSGQASYAGDLDKIIVYTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTG9</accession>
    <name>A0AA38NTG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_339390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTG9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000084">
        <property type="entry name" value="GTP-binding elongation factor Tu family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="181"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="612" mass="66789" checksum="5C0AE2D8E6F6C0CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTU4</accession>
    <name>A0AA38NTU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_281419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTU4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="229"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="334"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="469"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3790958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="560" mass="64944" checksum="598AA3A28C1FC80E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTX0</accession>
    <name>A0AA38NTX0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SSU ribosomal protein S9P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_430561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTX0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3791079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="367" mass="41523" checksum="9B2DC3C241311B87" modified="2024-01-24" version="1">MNILRSQIFSVLRRPLYRQLTTTARPFVPPAQLVFHDNLYVPGAKELDDSTVEALVGETNEQEPEDDEEDPNDDRDKPHPDSPNFYTGRSSYYDNIVELQNAISRTRGTLQRLHLLPLPDFARKSLQPMPTVWKTPEEMTTDFETNMTISRYRRVTTLLNELNEYLRIATTAGYADVADRIGSIISIFESGKKEAFLSRGIRKPVLLDQHGRSYTFGKRKTSAARVWMIPVKSSHETSSDVDVEEVFGLSNEPKRSSVNVTVSTILVNNIPIAEYFPQPVDRERIVRPLKVAGVLGKYNVFTIVRGGGTTGQSGAIAHGIAKGIFAHEPETGVVLKRAKLLRRDPRMVERKKTGLAKARKRYTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U085</accession>
    <name>A0AA38U085_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome 26S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_158713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U085"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="76"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="265" mass="30312" checksum="2A357B2F4AFA3109" modified="2024-01-24" version="1">MAQNQLKSLYNDLKRSFEAKPFDLKKCGSLLAKLKIGLIETGLLIPQGEHNIDDLVVARDILEIGAIWSIRTRDVPSFDRYFSQLQTFYTDYSSVLQPSKNEYPIRGLNLIRLLTQNRIADFHTTLESLPIPADAIADNQYISHPVNLEQWLMEGSYSKVWNARERAPVEEYKFFVDSLMGTIRNEIASCEEAAYESLPLKDALTLLFFNNQSELLTFAQQRGWQVDLSRSLIIFATKGEEQAEIPKQKLISSSLAYARELEQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0H9</accession>
    <name>A0AA38U0H9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_392463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0H9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041397717" evidence="3">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="128" mass="14415" checksum="D5E407C5D0DA9864" modified="2024-01-24" version="1">MLFYISLFALVALLVLIVHRYRSSIAPHIPHRVKSMFPSFNHYVPLSTFADQAGAGMSSSNFDIEANIRDGDSRTGLDERGTQEVMEIMRQERVNFDQARLIRQNRILANNGIDPSGMPLDSKAVTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U717</accession>
    <name>A0AA38U717_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">At2g23090 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_179526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U717"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="74" mass="8333" checksum="579A4EA4A227E726" modified="2024-01-24" version="1">MGNGAKANQRRERSAKNTDKGNTSQKKTNEAAKSIICQSCRQDFFITTRQPALEEHAQNKHSKTMTECFPTFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7C4</accession>
    <name>A0AA38K7C4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_19873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794451">
        <property type="protein sequence ID" value="KAJ3779649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7C4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041484173" description="Hydrophobin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3779649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="134" mass="13281" checksum="BAA32957F5A726C0" modified="2024-01-24" version="1">MFSRISTVVFYALFAFAILAAATPGGKPTTTTPPITTTVTVTAPATTTTVTASQCTTGDLQCCDSTTTAGSAAGAAILGLLGVVVQDVEVLLGLTCSPITVIGVGSSSCSSNVVCCEDNSWGSLISIGCVPVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7M9</accession>
    <name>A0AA38K7M9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_151783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="MU793781">
        <property type="protein sequence ID" value="KAJ3780339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7M9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="149"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="452"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3780339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="762" mass="85411" checksum="11ABE840F289938C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9N6</accession>
    <name>A0AA38K9N6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_357379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9N6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="525" mass="57316" checksum="51B656ADA2D14E82" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA72</accession>
    <name>A0AA38KA72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_354410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793337">
        <property type="protein sequence ID" value="KAJ3785604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA72"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="156"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="806" mass="90708" checksum="E820F098EAB905D0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBG7</accession>
    <name>A0AA38KBG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_135328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="161" mass="16824" checksum="BA7D055D97F21BA9" modified="2024-01-24" version="1">MNEALVYSALFGFILTVCSFAWRFCWLSLSSDVKDVGYVINYDFPNNCEDYIHRIGRTGRAGMTGTSYTYFTTDNAKQARELVAILKEAKANVPPQLEEMTMFGGGGRSRYGSGGGGGGRGGRGGGYRGGGGRGGGGGGGGGGRWGGGGGDNGYGSRNDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBH4</accession>
    <name>A0AA38KBH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_279798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793877">
        <property type="protein sequence ID" value="KAJ3780163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="721" mass="82979" checksum="5D76D777D95FCB73" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBJ7</accession>
    <name>A0AA38KBJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_414361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBJ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="489" mass="55122" checksum="1E11F8C0AF02F0EE" modified="2024-01-24" version="1">MSYFANSLAFARHILDDQPVQIISTTAMLAILWVLFAGDGALLARARHVQGLGVFVLLPFGFKVTFIYFLLYVVCTTYGATPPLPSQSPDPEYRAVLPETDPDDYWAPPTRSMSSLRPQTIQLPVRGWSIDVKFSLESPRVVLEEYHFNFAEELDKNLAIPGRSGTVDIEYTVNPTDHRDPDLLFDIWDARLKIIHRQHRRISIYEFTLTQVSIPLPIDKIPPQLRKGGAGGNRWSIKAPDFPQFRDFVQGALKPEQQVVSTTGNFSDTQYFEQTIPSVDLAQVRVFIIVPILKAISFESNSLYGGVYHSPFYGDTKNFTWDSLTCVSLASVQIFARDYRAILEASPNLRTMKINRPGEGDGGPELQEPDEVVRANRLETLHLTNCKVDVRDFLSASVVDLPEVTELVLSCHETKQSFKAHEMGVKWEGIHILKLSTTFGGQFIHDCEARLSTDSMLEIIIFSELPMGSIEIASVPFQNFIQVIMVFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBR7</accession>
    <name>A0AA38KBR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_307599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBR7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="34710" checksum="BB1AA8C298B36266" modified="2024-01-24" version="1">MAILSSLFKQTMLAGVALQLWLASLQDVGVSGSIQRRAVSNVVRVLGYTPSKPAALVAAIVYIVCGLCFFYHVFRRRNYWALCLPIGSCAMGIGFILRVMLNNPDHQKRGPFVSEEILTACSPATFLAFNYIIHGRLLGRSMGKRHSYIPPNYVSWFFICSDVLTFIVQAAGTAMFTKTSTLNTGKTVFQVGVILQSASYYIFVIFYFLSWRSCRKEGIATGHEAWWKIYKLLGISSFFIIVRTIFRIAESCSDPGTAIRTREVYLYVFDTLPLFLAIVGYIFYWPGPYFERDSIADAVPMEKVSTSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCA0</accession>
    <name>A0AA38KCA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Snare associated Golgi protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_344386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCA0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="202"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="492" mass="53215" checksum="76A9E395290765F5" modified="2024-01-24" version="1">MSGLTPPPISRNRASSTTLRPALTLKSLGRRRSSTQLKPVPSTPSTPQCSSPSGTAQPSMFFMALSTALQWLHPDSKHVLLPDWSSPSTPEDSRDVYDLPLPASATKSSFGDVHTTKSSQRNTWPSIHAPIVFVICLFPLSTVLVLLSLSSLPISFSWPKTLTDLAKLGKELHRYSGSGLAPLAHVVGVLALTAVWKHAWSIPGSVIWNVLAGALFSPVFATVLLTVLTTIGSLCASSLAAPLAPLIMHFFPRVLDMTRTALEGDAGRLVPSISSGSETDSSVSEKSMPSQIHTSGAWVRLSVLRLVGVVPWSGINIACGVCGVPLWDCMLGSFIGTLPWTAVTCQIGDILQTVASAPSATTQTVSSLLMSPEIIIKLVFLSFLSLAPILARDHLKALISTSVTSSDSVSEAASLPIEPSTSEKVVPVSSQQSEQDEKRVSRWTWMKEWKVRLPSRSRTREERDKSDRMRKLDELVDEKQKIREREEGILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCM7</accession>
    <name>A0AA38KCM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794910">
        <property type="protein sequence ID" value="KAJ3779441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="246" mass="27347" checksum="6E84865C761431AA" modified="2024-01-24" version="1">MTALPQLSAAFRKLNNDMADEIEFNAHGKIGSCSSARAQKFRNSDFPSPGDLKLFEAFITPPISSIVPKYTPRLPNVQGIAAFCQKQFGWQPELAFKKLHANLWPAVIIQMLCSDSVAYNPNNSEILAPQVEPVEDNLQIDSKGKSFIPTYSTTILNQKPLDLQAKNIQNAISITFCTNIFIQLSGLSNVSLTTRRRFNVPGIIIAYAMNNVHLKHSLSEPYNLSSPEFIVDCLLKQVPAFSPKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCP5</accession>
    <name>A0AA38KCP5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794671">
        <property type="protein sequence ID" value="KAJ3779546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCP5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="345" mass="40129" checksum="7DF25D9C48E943C6" modified="2024-01-24" version="1" fragment="single">HHTRLYTLDSQVQYADRLSLLGIGNWLARKWRNTQTRRLEADTQVISSAKQDRYLREQWKSQLSSQTRPLPRQTKNAGRSAVEEAIRLRKVRDTLRDRVSALEDVLSDINSEDYQVAEVEGKLPDLRGKLAQVQAKLIRQEQLLGVVGQQQYRHLATSPFMALRMNAHALKVRLRNRLTSRKFERDRIERSFRRQQYNDRKVRTQTEDAVKRRDPGIQALARQYNILCHKMEELVRLKRAPRNAIAPQPIPLKELFDLDVDDVIWQDVGLDASGDIENPPAWLTDEDVKSGIKGILLRDRCDEELRRLKHECIALYHWLSEEWQVVNACIEAATNLGRCSDIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD22</accession>
    <name>A0AA38KD22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793450">
        <property type="protein sequence ID" value="KAJ3782848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD22"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="490" mass="56201" checksum="B490711C5ECF1716" modified="2024-01-24" version="1">MAQLPDLPVEILSCICDNTEFASLFSLARTCRVFNQLAERRFLQLTKFDVQTRHLNIVSEQELQLSDSKDAFSFNSARRLCAFFGTLLNIESLTCTFPLSSSLATIRQMAYLVQILRTISAQQGPRDSCPFSIVLEFDGDPGPSVKAQHESRFGQVFRSLLCEIRRLRCDSLELRDRLPAFRNAVSLELPIDDALERISIGGSWLFSWSRPWLIELLNSSSKLSSINAKCSKIWTEILPKLCLPALECISFYWYLDDTEASNVKVFVDFAKRHPCLGTLDCGEQFVVTWASSRCTELLSNIVTLRGTISQLRYFLSSPDTSLRKLEDIEIRGKSAPARYRNYHSWEPYNKKYPLWELFALISTRPSIVKVILPMDLAGFQKQLFPEFKQGRLSITTRSTLPRIRYLVFKRSLTLYVESIADFVDWACQVFPSAERLEMLDSDRTLGRPLVQCVKGQWPSIHHLVMDDHVYAVQDQRLGIEVVHIVYDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD59</accession>
    <name>A0AA38KD59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_389427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793442">
        <property type="protein sequence ID" value="KAJ3782998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD59"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="483" mass="54573" checksum="360D6840A9D05C8E" modified="2024-01-24" version="1">MAILFSANAFLTTSLVLVVLAFFTKRKIKEIYIDVLAIACSYDLLSSSFKAGENTFHFSLFGNPVVGLRGQEARKTFFNERSFSTSEGYKMFSKAVPMPELAKTLLSAEEEHGAHFRKQLDILVNKNRFAEIIATMLGDIQRAMATWNDEGTMDPFDKVNDITFLVTARMITSSDFVSHPVDFSQFQENFFTQLNNTPTMIFLPWFYRAAQREKEIAITSLFTKLTAYLETREISDASATEPIDVLLAHGMNTQEIIQFIIGFLFGSVYNATKAVSWILIYISLHPHWISSIRSEVEGVLSGVPIDASEPLHSKLSQVPIEAWEDSMPILDLVISETLRLTMNQTVLRRNVGEDVQIPGGNGSVPSGAFAVYSHADAHLQPEIYPEPWSFKPERFKQGKPKVSNDFLGWGAGRHRCVGMRIAKVIIKAIVCLFVMNYDYDIRRTKRRFSSTMSIPVPDYNKVNEARPKGEVITLRYKRIGQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDI3</accession>
    <name>A0AA38KDI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_278553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793633">
        <property type="protein sequence ID" value="KAJ3780896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDI3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="102" mass="10946" checksum="25484895772918BE" modified="2024-01-24" version="1">MDYLEKQLQTSANAVKAPDKNCNNCKRIGHIAEECFRKGGGKEGQYPSWWKGKKDAGGPSANVTTTPEVGELTQHYGLAALAEGVSEGEVFADTGASDHFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDL6</accession>
    <name>A0AA38KDL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GGU10DRAFT_379894</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="MU793605">
        <property type="protein sequence ID" value="KAJ3781091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="29"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="207"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="471"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="570"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="658"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="735"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1109"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAJ3781091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1208" mass="137234" checksum="58D01EA761D1FD1E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDN9</accession>
    <name>A0AA38KDN9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-terminal nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_359790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="35934" checksum="D66C57A869CCCC15" modified="2024-01-24" version="1">MCRWIVYVGEHPLMLEDLLIKPKHSDTLISRVSERFIPGLYHGLEEDDVEELKKQATWINVHGFGVSWYTDTLTEFDPSIKGMLPAQFRTIAPISTDLAFEQLCKHTASKCTLAHIRDASFPPVVEVNNHPFIYGKYSFMHNGSVDSFSKIRYDVMKRISELQTMVQISQYKSSVQDSNYVFGIAGNTDTEHLAALYFAYVDIIQAIKPSFGAHSTDALLLALFLTIGDIREIQFQHQVGSFTPAAGGVQMLVSRWRDSKKGYPRSLYLSLTAGEKLNRKHYSELPDPTSLEDVYNTDVKIDSVRELVARYKPTKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDU3</accession>
    <name>A0AA38KDU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_411507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793550">
        <property type="protein sequence ID" value="KAJ3781511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDU3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="418" mass="48497" checksum="7EF3DA3AC4FFFCC0" modified="2024-01-24" version="1">MMFIRNGPLPNDPSIEAPQRVRKTHKDPETNHRLAKLPIDSKLKMNYEKQLRNATRRERAIERADNMSDVSSYISIPEEEYEKIIKDHPYFDRVKVWLSAHTLSWLTDKRKQLRTRTRDSDDTLNNAAPAQPLKRFRANNELNEVDPTIRPFISFDQAFLDLGLHGYNVPLALFTNKNIDFLNNNPISFRRTKISHIAGKPQILDLADVMKKMRDSRDAGTVRELELEHFEWIEATENFYAYQVSLYAEGTDAHEPTFYRKHFGFFENQVDSVKLYDLWKDIELEMHQKHQNKRTNFDLFDYRTEWGRVKSRFNAIGMRNQKSHTDSPPVSSSNSFPTGNKDKGSRIPCCIICGGAGHTYLVHDDNTHGPPKWATREGADLLHPRTRAWICSYWNIFSTCSKKCTAANHICTLCGGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KED1</accession>
    <name>A0AA38KED1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_363419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793467">
        <property type="protein sequence ID" value="KAJ3782576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KED1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="442" mass="47151" checksum="665CB83CFB2BC976" modified="2024-01-24" version="1">MSHRAAKYLAQAPSCNVGCTFLSIRISNCRPYTANISDPNLTSLPSGRSSISFLSLIVSAVRVRLNEEGVSSRTLTAPLQVTGSFQIEPDDPSNIVYNVVNTSNHANQVIQTKLAPDDEIYGSFPVLLVEPGVFELQAYAGAPDVNGGDCQSSGSFSSTHRTQFPLTSISSSIASSESHLPSSRPAITSIMRTYPSNTHWSFDSNTVPLPTSGTLSQSTPTTSSTESPNLAENNSKARHQHLVDGIVGGLIGLFMLLILSFCLARFVRRRQNNPSHRFWDGDGDGGTKIARIRHFWSAMRVDSNHAQSSSSIIPFTQAAVVSQTGPVSDKTVTLNSGYAVTAIPLGSVIRHTNGSNDDDIEAGISKSRPTRDGSEDGSRSIEQNRDRGSVNAISGNGTLTSGLIVGATITMITSGDYVSPPFSERTTPPPSYRSATKAVLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEK5</accession>
    <name>A0AA38KEK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_274628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793446">
        <property type="protein sequence ID" value="KAJ3782921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="489"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="65189" checksum="4A9D721F17162700" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KER9</accession>
    <name>A0AA38KER9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_60847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KER9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="296"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="707" mass="80371" checksum="2017957875FB0A2E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFM5</accession>
    <name>A0AA38KFM5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_271674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793380">
        <property type="protein sequence ID" value="KAJ3784346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFM5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="87" mass="10212" checksum="76BE55588503033E" modified="2024-01-24" version="1">MCSRVIENEGRAFSTQEVYSRWYKLTNERFEPDRQMTHQKYGKKALPKKLVLQTWKSILAHEEPLPQDWTTINGVLVGITGMVEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGM5</accession>
    <name>A0AA38KGM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_345782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGM5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="177"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="731" mass="82239" checksum="CFE13001E0869062" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHB3</accession>
    <name>A0AA38KHB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dbl domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_265392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="300"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="521"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="750"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="976"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="813"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1345"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1354"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1375"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1406"/>
            <end position="1415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1415" mass="158490" checksum="8E8B2C3C473ABDC1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI66</accession>
    <name>A0AA38KI66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_79268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI66"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="316" mass="34485" checksum="264940D198DD8FD7" modified="2024-01-24" version="1">MSSTSQKNIAIVGVGGIGTHILRALVATNLANVVALTRSTTVHPHHHHYLHLHSHEQQHSSPPRKTLPSDLSSVSLIEADYTNVPAVTAIFKEHDIEIVISTVPAAGLHAQYTLADAAKASGTVKLFVPSEWGLPSEGASHRGEDNTFGIKDGLSAHLRTLGLPYTRFFTGFFIEYLPWFVGIDTNHVVNVIGKGETPFSVTSEEDIGGFVAHVLTTVPSSSPHLKNQCLRIQGDRITMRDLARIYHKPLEFVPEGDEVPAKTPEEAALKTFLQIEADGGMASTGWDRLTKTERGDAGSANWLWEGHVWKRVEDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMC8</accession>
    <name>A0AA38KMC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Halogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_274578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>melleolide F + FADH2 + chloride + O2 = 6'-chloromelleolide F + FAD + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:167712"/>
            <dbReference type="ChEBI" id="CHEBI:167713"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:67161"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793445">
        <property type="protein sequence ID" value="KAJ3782924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMC8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140907">
        <property type="term" value="F:flavin-dependent halogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57331" checksum="E8FC17018D9A4C1A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMQ3</accession>
    <name>A0AA38KMQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_77955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793469">
        <property type="protein sequence ID" value="KAJ3782550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041219567" evidence="2">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="155" mass="16313" checksum="4F09A68990E7B45B" modified="2024-01-24" version="1">MYSKSFTSTFTLALVSFLAMFVSVSYGAPIAIRRSTAIAGRQDTTSSGTTYSGDGTWYETGLGACGITNTDGDPIVAAAWQTFDQYPGATANPNDNPICNKQVTLYYGGKSVTATITDRCAGCEGAADLDMSPSLFDTLVGDPGIGRVSITWHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMW7</accession>
    <name>A0AA38KMW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_274876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793453">
        <property type="protein sequence ID" value="KAJ3782790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMW7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="235"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="592" mass="68311" checksum="3D34256CB4B0A733" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNQ3</accession>
    <name>A0AA38KNQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_123270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793611">
        <property type="protein sequence ID" value="KAJ3781041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="112" mass="13009" checksum="0E4F6A809BAE5738" modified="2024-01-24" version="1" fragment="single">MSTTFHDLPTEIIEEILILCDPIEVGMISCCSRLFYNLIYNSRGDSSQHLWRALYLAQPFDDPTRCVSHHGRPRVGEFNWKSELQAIIRARTVLKDVSICKPYERIQVLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNR0</accession>
    <name>A0AA38KNR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_28373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="155" mass="17531" checksum="38D0A9C1AACDAB81" modified="2024-01-24" version="1">MLYFFLAVSRIRFPRLHLWSSYTKDNATIIVYTDWFLTCPAENIIAAASKSTALPLWQRAHGLSFYDPFGLCTFPILSRTTGVILVIHTRSSERTTSSLNPCAYQLTFRTRISSKISGLLSFERELKIQTSQLKDLRIKACSGCSRTRSGSGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP25</accession>
    <name>A0AA38KP25_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_376456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP25"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="459"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="744" mass="80144" checksum="BE767EEA3FDB7EA4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPB0</accession>
    <name>A0AA38KPB0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_270179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPB0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="197"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="408" mass="46633" checksum="3932BB8526FDBF56" modified="2024-01-24" version="1">MDDQRQQDDWENNRNDRLPSFTEVLSRRTRPPVDLFMFYLFLQREGAEDILDFWLDVQQHENLCRAYFKDVRKSGRTIKEDWPQYWDYARRRGSIYGTVVGLNTDGMHTKRSTASTGELLSEQDKRNLAATDEKAAGRSTSPRLTPGISEHTHVASTSPTNDRPTTPFSLSGRTPTLFNLKRASRAPTVIPRSSAITRQDLIASAERIYFRYLSPAANTVNSQENHEIYLPPSLRIHSFPLSSSAEPRSQSEMAIMAQIPDMFHAQKEYCFRAMEQDAFPRFLRAKAFGNLTPISALVRLILGLVLLWIGLAAAFSLVFLDVRPKSKRFFLFIPFTFAILFLVSHQYELDPILVFLGQSETTPFRTLRIKEPYVKKLLLGRAIWVSVLVAAFVAALTLIFWAVPGHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPB5</accession>
    <name>A0AA38KPB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_365930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793533">
        <property type="protein sequence ID" value="KAJ3781686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPB5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="248" mass="27451" checksum="5CA4EADF50C44F66" modified="2024-01-24" version="1">MHGNSRTYSYDDQGIGYSQSNTANGGGHTSNYSYTEHIYPEQSSGHYYSSASQSGIAAHGHSDPRYGRSTTPAPGMGPRYGRHPTDPRYYHSSGGISSSTSHGGNVPPSAPLFSTHQYPTSQSPASHRDRFIPTPSEIAHAYGNYSGSIPDQHLSQSPSTYPTPGHHSRYHRQTSTSPILSTTRATTIRSSHASATSPSNERFPCEICGKTFSRSHDRKRHHETQHIPSPVLHRCRYCRKEFSRYAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPD5</accession>
    <name>A0AA38KPD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_315277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793382">
        <property type="protein sequence ID" value="KAJ3784305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPD5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="217"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="389" mass="42399" checksum="AB620E096D7E42BE" modified="2024-01-24" version="1">MASYVRSLFGGNNNSARSRSSSSSKGHSESSRSKSHSRSRSTTSSNPKPTIVYVHSYATSTSSALMPSPSRTPRPSPLRYNTYDSTSISSKTRPMRPLELRSGSIDYQSVVPYPIYTPDLSSNSRTTSNSSVYSPSSVSGHGHNYSSSHQGHRPPMGPRTSSSGSVPRPALKQTNTWHAGESTSRSQAHVSFVNPKRRITLHMHPLLATSQFSRAPICYDVSRPPSPQTIVDRNTRSAIPAVTLNQPATDPSTMSRLVLRSNKFPWPIIVDAGCSSQKKTVPKFYLGGSSPTGLHHPSSLSVSCADVLHAVHTTLSHPATPEEWDALGRGSHAQRKISRAYDRRCRSLGSGWDGGIRRVDWLGEKFRLIGVEVDKDSDSRVGNLVFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPU6</accession>
    <name>A0AA38KPU6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_312467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPU6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3785699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="182" mass="20560" checksum="3690B610E3EB2E22" modified="2024-01-24" version="1">MGANLSKALGKIFGNKEMRLLMLGLDAAGKTTILYKLKLNQSVTTIPTVGFNVETVTYRNVKFNVWDVGGQDKIRPLWRHYYTGTQGLVYVIDSQDRDRIDEAKQELHRILGDREMKECLLLVFANKQDLPGAMSPAEVTGKLGLHNMRDRSWYVHPSCATTGEGLFEGLQWLSQTVKKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQC1</accession>
    <name>A0AA38KQC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_386725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793316">
        <property type="protein sequence ID" value="KAJ3786359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQC1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49190" checksum="FFEBBD45C3EBF33A" modified="2024-01-24" version="1">MSDTDQNQTPWRETGERAMNINDSGDLDIANGSDNHHKAQNIKSTVDYPIGASIPAKPDVEPPVLHEKQVKPNKVYIGGLPEHTRQEDLQNCFGKIGNIVAIEVKVGYGFVEFDTREAAEMSVSKYHEGTFMGNKIRVELSRGGGRTAKYSSDPLSCFRCGQLGHWARECPLHPGPPPSGSSRRNNGPLIDRLDRVQRYHLPPRSPSRMSPPRDARDTPSSRYDYPSSRDYRRPPSPSSRDYRRPLSPPSRDYYPPPRTRYDDYPRERDRYIPPPPPSDHRSSSSRYPEPAYRGAAPPSPYAYDRSDRYNRDSKYVSYAPPPPPPVLPLGRPRTPPKYRSDYPPSREYDYRDRGKPATPPRYSEYPSHRVMTPERYSRRSASPPPPRSSAVYDYPPGSQSRNYASTPPGPPPRSNRDYVRSGRDDTDMYRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQE3</accession>
    <name>A0AA38KQE3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_290266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQE3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="523"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3786449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="602" mass="65890" checksum="DB1C02ECECA772E7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR15</accession>
    <name>A0AA38KR15_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_232157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="242" mass="27795" checksum="957CD913DCE97BFF" modified="2024-01-24" version="1" fragment="single">LGYLAFPTIGSPLANNTAPASDGSHLLDSSDTSTVPAEMESAKQPPRSVDPLQERHRVRLELEEAERIRGEEDWVRSGGILRDSEGKRDFPRTEKVREEIRLREWEKGARERWDEYERRWAELQAKERKGDSEITFNDIPWPVYFGERGNDQTKSSKLGTWGTVAIPPKVKLSDITRENVETFLTDGLKVRGCKVTRKERVRTSFLRWHPDKMTALVSKVTEDDRKDVEDGISAVVRCLQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRD9</accession>
    <name>A0AA38KRD9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microtubule associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_167952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000068">
        <property type="entry name" value="cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000063">
        <property type="entry name" value="Putative cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="284"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="619"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="881"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1252"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="842"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1493"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1933"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2079"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1552"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1585"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1611"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1950"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2092"/>
            <end position="2101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2142" mass="230082" checksum="91DFE316072318A9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSA9</accession>
    <name>A0AA38KSA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuole protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_384623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSA9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57419" checksum="C81761DBBFCD9687" modified="2024-01-24" version="1">MCSGPKWKREIVPDHKFDFVDTREFTDNGFIMRVKYLWLYIIVLKSFLVYVSDIFTAITMLTTTSWSNEIFNNCQQFGCVSIPYNTGKWLFVGCIIFSFLLLAYETRKSKKIIASRDISYAFTNVMAQHYYSLRSYDHFCFFDHISNSTKLSDDFAFFVFFTFKSWKRVLLADGPRQTINGLTLYAIYLAHKDEGSWYDVSKYFEGNSLSTSALTVTTFFTVVVFAGSLLLLIVAGICYIPLLAHIRGNLKEYCCHKVDKRIDTVIKRRMKQRLVDAAKLAKKEAMGDYSHLKNKKGVIVGKPLPQPTLPNLSVDDDDDRSSIRTRGPPPSTYTQDSNYYYYDKGGAYPPPMPAYNPYSGNQPAGSYAYINPSQPALSREDYQPGYEEDDMTGLAVAAAPFAQQSQTHLDAHSSSLTNPYSPGPTGGTGFDAHDVYQGRDSHSPEHDGLAYRSNSHSEHFEGLAYDQQPQQGAYHRNYASHHQDYAANYAANAPSQHRDNGGGAHGYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT09</accession>
    <name>A0AA38KT09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_306828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT09"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="127" mass="14742" checksum="D3309D57A0FDE669" modified="2024-01-24" version="1">MRSKFKDEHPFEKRKAEAERIRQKYPDRIPVICEKADRTDIPTIDKKKYLVPSDLTVGQFVYVIRKRIKLAPEKAIFIFVDEVLPPTAALMSAIYEEHKDEDNFLYVSYSGENTFGSEGWLGLPMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT24</accession>
    <name>A0AA38KT24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_419801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT24"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="33"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="334" mass="36891" checksum="8D2F45D05C85B40C" modified="2024-01-24" version="1">MASTSISKAEKSYIQAGLLANPPRRADGRSLHDFRVISLETGFAPLSNGSAHLSIGRNPHNGSGGTDIMASVKLEVESIEEDASDGGRIVCNVSCSPSAYPHLTSGALDDLQYDLTTVLHQTLSHPSLHPKNLSIIPRKKSWLLNLDLLVTADAGNIYDALFMAARAALWDTKVPRTRSVEYKSPKSLSSASGDMDVDQDTTSGFDTRKVAHATDFELPDYWDEGEILEGRERWPVAITLNLVKTIHFLDATLQEEASCASRLLVVHSYESPTSPTVQSMRMLGSEELSILHLKNLIKEAESYTNTMFSSLTAKLEDEDFRRNQKARERFGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT55</accession>
    <name>A0AA38KT55_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793886">
        <property type="protein sequence ID" value="KAJ3780147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="187" mass="21132" checksum="951D79C4DF434849" modified="2024-01-24" version="1">MIPIPVADPAVLLSDRQQEPATSTTHSEGKQKKPSTKAPRRRPPPIGKNLRVIKSKTSPSLEIYQFEWRAEVANVDQGSTSFVHETMKQQTGSQNHFNAVQPEIQQNTNWLGKQFQYPVQDWNVLDPQSQQSLSQSPQVWHQTRHMYALITQGEQPQGMAPQQSVQPQNQLTKIKLLDLPIPPKGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTH5</accession>
    <name>A0AA38KTH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_417513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTH5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="57"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="424" mass="44945" checksum="1B566CA484A86746" modified="2024-01-24" version="1">MAICLRAFRLLISSKSEIIQDGAVVVGGDVIISAGVWSIIQPTLPQAARIINLGDVTMMPGLFDCHVHLFMEPSSFQTTDVASPLDADLVLRMESNCLRVLDAGVTTVRDLGCIRTLSTELRARVNAGLAQGPRLTSILSANAPITVPGGHASSWGGTASGVDGCRAEAQKRVQEGVDVIKVMTTGGFLTLGSSPAKARYSVEELRVIAEVAHTHGIPVTTHATGVEGIERAIDAGFDCIEHCSWSVEGGTKFNGEIAKKLVAQKVTVCPTMNTACMEKDYYCPWDTRENVLQNLTNLREHGVQIVVGTDNGIVGCPFERYADGLSVLIEAGYTLREVIASATDKASEVCGLSSVTGKLLPGMSADIVAFAGNPLESVESFAKPRFVMARGREHALTPITPVDNAKLAADVARKLRKGAGLSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUR5</accession>
    <name>A0AA38KUR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_436563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793468">
        <property type="protein sequence ID" value="KAJ3782562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUR5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="190" mass="21653" checksum="329FBEC0C2B8297A" modified="2024-01-24" version="1">MYTSSSAERTSIPQSRHQVLYIAFAEFLFSITFLVVGIFLLYTLGEQILDADAVALNLHIFAYFFLGLSTTLGSRSLVAMFCSMILAQLVFGLGSGIYCLSILFNDPGDIISRLLHNKCSHLDHFSKAFCERTPMMKYLTLALFMQMWLIEILGVYYAQGYVQELLDEETDGVKEVDYEFDYDYAYYGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW97</accession>
    <name>A0AA38KW97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_395057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW97"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="334" mass="35798" checksum="82EFFCCFDB0DA262" modified="2024-01-24" version="1">MFASEAAIWYNIPEFNVLERNITVPGFSPLFPEAHCTQDGSICQIVTGEAEINAASSMSALVYSDIFDLTTTYFLIAGIAGVNPKVATLGDVTFARYAVQVALQYEFDAREIPADFPTGYVPQGTVAPDQYPTSIYGTEVFEVNTALRTLAVGFAKNATLNDTTATQEMRSLYANNSAFGPGASSGPSVRECDTATSDVYFSGTLLSEAFENTTSLFTNGTGVYCTTQQEDNATLEVLMRATLAKLADFSRIVVMRTASDFDRPYDGESAAENLFGDAPGYHPAVENIYLAGVRVVEGIVKGWNQTFEKGVKADNYIGDIFGSLGGVPDFGPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYZ0</accession>
    <name>A0AA38KYZ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_388297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041216790" evidence="3">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="60"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="357" mass="39637" checksum="40695C8E8EF55D9F" modified="2024-01-24" version="1">MLYQALTAVFCILSAFSTLAAAQTASNASLLDPSLYKNANVSRGLVYHYYYSPPSQVGRPTLLLLHGFPSTSYDWRHQVAFFQDEGYGLVVPDMLGYGGTAKPVDPEFYKSSLISRDMVDLLDAENVNEAIVIGHDWGAKIVGRLANYFPERFSAFAFLSVGYFAPAVLERSFAELNNITQQVFGYENFGYWGFFSTEGADNIIESHLDSFFNITFPADKILSITDFAPLGALQAWLEANRSTAAGSYITPEERALQIDAMRDEGMTAALCWYEILTSTIERDDNQGIPQENLTIKKPVFFGAALEDYVAVAASQIASILQVSENTTTIQQYDSGHWVMLEAKDQVNSDLLSWIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZ62</accession>
    <name>A0AA38KZ62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_356398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZ62"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="296" mass="33954" checksum="EBD8E420BE28C438" modified="2024-01-24" version="1">MLHESRTPEVLLKAPSIKTHYILPSDKSEIDRLNLQNQLLTREVCDGKLVFAPMELEHGDQVLESGTGTGIWVLSLAEAIPPTISLTGIDINTRLFRLEVPSNVSFLQRSVTNLPDEWTERFKLVNQRLLIGGLTRKEWEKGLQEIHRVLVPGGWVQCLEPCIPLKTDIGPHTERMFEVLRNLLSNNGLVHNIVEVLGRRLPRMGFVNVQTHTVSLSAHSNGDEFSHRTLMEWFFVALKPGMLATKLLSSEEEFEMLMQSMLKEWDESPKVAWSWSIVYAQKREKDTRTHKFCIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1K3</accession>
    <name>A0AA38L1K3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_397914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794182">
        <property type="protein sequence ID" value="KAJ3779812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1K3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="1">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="239" mass="25621" checksum="38EC8A7015F9D915" modified="2024-01-24" version="1">MRGREGVACTKKVKNNLLAAVLILTAIPPTTKVGQAVVEHSCFLISQKLLETHEVSLTAAHCARTLIAASASGNILLRCCVKLLMPALIEYIAKMVPLVNDGSISESHATAINEVWKAFAMFFGSLTEAARTRLLGVLLPTISLLLANSQNSPSPVVAQSIKQFLSYAAISPTAFKEAASKLDAPTRELLETSIRRAVGGGPQTAALQNTLKPQISLRSFWSRWALASIVITVPINLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3E9</accession>
    <name>A0AA38L3E9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_360714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793417">
        <property type="protein sequence ID" value="KAJ3783472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3E9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="174" mass="19906" checksum="E227378347BB46D8" modified="2024-01-24" version="1">MADFYTTAKSTKNNSILHRRDNLIAYIIETPSRILHHERSTLYKGPNREPIGFIEFHGLHDNIVEINGRSFLPHRAHESNHLSDSKEFMASDGRTYKWKHHSHGVWELLTQDGSHTLVARYDRNNISVYPQAILVQDEVILTLIYMRQCKEKEDDAAMITATTSIGPIAGILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3M8</accession>
    <name>A0AA38L3M8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_41895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3M8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="85" mass="9169" checksum="47FC20280F5325E2" modified="2024-01-24" version="1">MSQRSILITGCSVGGIGHAFVKEFQSRGFQVFATARRLESMSELEGVKGVTLLRLDVTDIDSIRTARNKVSSLSGGKLDILINNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3N0</accession>
    <name>A0AA38L3N0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_92115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793512">
        <property type="protein sequence ID" value="KAJ3781945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3N0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="39948" checksum="CB2594CE17DDE1F8" modified="2024-01-24" version="1">MCLLRLSHLFRLYPLYLLLAAALLGVAVVASPVPRANIKKVQRRRPILLRIGEYDWKHSGWKRKNDLTSRLSKVLCIGDIQCFGYTPAKGIGEVKPKTTQRSREITVDNNYYRTMKAHVDPQSFELGQQSLGESLSSVDKLQAAIRERIRIKDDESCIRAILDLMVEKGIAIDYDDQKSLEDNMASIHTRTLSILRFGFHDWSTNTWADKEVGIKPNFLCLPYAKMCLGFEEKESRVVVISPQYNMGKKTIDSHRHPSLVYTFDQQNRGFWSDPDQKHRTLVQFLQDTGDLKKVAGGDITDPESYIRAVLRYLSLDSVGIIRGYDSTKPLLDLIEPKGKNGWGWSRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L401</accession>
    <name>A0AA38L401_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_333831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793372">
        <property type="protein sequence ID" value="KAJ3784567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L401"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="697" mass="76093" checksum="9E33174517E6D9E4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L402</accession>
    <name>A0AA38L402_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_363281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793465">
        <property type="protein sequence ID" value="KAJ3782605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L402"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="68525" checksum="1DAF26DB099A6AE8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4B6</accession>
    <name>A0AA38L4B6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_361571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793431">
        <property type="protein sequence ID" value="KAJ3783205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4B6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="207" mass="23771" checksum="DAF970D8A75FF164" modified="2024-01-24" version="1">MSSVENEAERRTQAKPKNEGLSEDEDKVTIGTENGSKDGDEDPYKLARMHAFQLSVLSHNYPPVNNDLPTGTKDLPAKFQVVPKTLEPNAPKVHYGFGLYYIDVVEYHKAHHLKSRLPHPTLDSGTYTCGICLTVLEHITRCCNFGFIDIQPAKTLEFDLILSLYDNHTIWNRELVEAEEKDVISIMRKEMPVLKDRELRWFYPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4D7</accession>
    <name>A0AA38L4D7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_355490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793348">
        <property type="protein sequence ID" value="KAJ3785257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4D7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041442123" evidence="2">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="20959" checksum="1ABDE7500CEF711E" modified="2024-01-24" version="1">MFSHKVSSFSFASALALLLAVTNTANALVLPPTVAMKRASRTESIAQPMANARSLSLMTRDVWSPNITSPNSNTVWNVNDHADVTWDTSGAPAQITNPNGTIFLGHFDSTGSGSENLDLEHPLASYVNLTLGKATIQVPDVPTGRYIIVLMGDSGNHSPEFMIHSGSGGAANSTSTGSPSASTDSSSASDPPNTVPTTTQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L557</accession>
    <name>A0AA38L557_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_356769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L557"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="471"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="578" mass="64641" checksum="160F2CB375C48E11" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L573</accession>
    <name>A0AA38L573_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L14-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_15651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793361">
        <property type="protein sequence ID" value="KAJ3784870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L573"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="136" mass="15321" checksum="1B79ADE448D83F8F" modified="2024-01-24" version="1">MSDSTFKRFVEVGRVVLLKSGPYAGKIAVIAEIIDHKRAVIDGPTTSVPRQSYPYKHLTLTPLALTKLPRGSRSGAIKKQLEKEDTLTKWNNSEWAKKRAAVEKRRGLNDFARFSVMLEKKKRRDGVRKAVKASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L595</accession>
    <name>A0AA38L595_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_376242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793357">
        <property type="protein sequence ID" value="KAJ3784975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L595"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="210" mass="23753" checksum="1B545CFACF4E2950" modified="2024-01-24" version="1">MLALSPARDLFALSSSTTKAPYHNSSDLPNSSLSLNSALNSSFSFTKSFTSSSRQQPFVETPAQRRARVAFSQKDNHEGERRVERVVSWVRDQAQHSAFMVKSAKMLSESEKAYKSHKRRSGTSSYRREGAFAPKLVPDEIILGRMFKDSSNVLSSITEEEEPYILYSTPIPRYSMPAPYFNNTHPFPTNSSRKPSHQRRLSDLEAIPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5Y0</accession>
    <name>A0AA38L5Y0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_311606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1526" mass="165796" checksum="C7B9DB1490A00037" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAZ7</accession>
    <name>A0AA38NAZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_243946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794275">
        <property type="protein sequence ID" value="KAJ3779746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAZ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="74" mass="8600" checksum="671E4F8405DFAF49" modified="2024-01-24" version="1" fragment="single">LYATPGYWAQEYHTSKLSGAQWVQELLVGHPDRIYTELGMRVHVFTAFVFELRLCGLSDSRYVKLDEKAAIFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC26</accession>
    <name>A0AA38NC26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_73419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793456">
        <property type="protein sequence ID" value="KAJ3782746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="593" mass="65942" checksum="E15AF3DCB94CED02" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCE4</accession>
    <name>A0AA38NCE4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'-5' exonuclease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Werner Syndrome-like exonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_359837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793403">
        <property type="protein sequence ID" value="KAJ3783796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCE4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="11">
        <location>
            <begin position="53"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="513" mass="57224" checksum="CFD3C8B9962016CA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH33</accession>
    <name>A0AA38NH33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_382581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794938">
        <property type="protein sequence ID" value="KAJ3779432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH33"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3779432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="140" mass="15785" checksum="844D6F5E00D0B9C0" modified="2024-01-24" version="1">MLNISVVKVAGIEKQLAEALEELDAAKEKIGRYEAAVEEDLSCDVCTLPAWQPCILPCGHSMCADCLYEDARHRRLSGRAIYSMKCGYCRSRITRAPIVSFDWQRRVDAMALEKGIPIPKRNPFKWPPAGTPKNHRSRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHT4</accession>
    <name>A0AA38NHT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_95771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793523">
        <property type="protein sequence ID" value="KAJ3781802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="70" mass="7605" checksum="570F23473BCCEE75" modified="2024-01-24" version="1">MFKNAATRLAHSSTLPVLGNKELKPLQDLIIAEKTVLVSLQRLSSDLGKASDTLKTWASGQGEELEVCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHT6</accession>
    <name>A0AA38NHT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_365482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793521">
        <property type="protein sequence ID" value="KAJ3781832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHT6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="706" mass="76817" checksum="7EDDB0D857B6C3D3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIF5</accession>
    <name>A0AA38NIF5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_272867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793405">
        <property type="protein sequence ID" value="KAJ3783752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1084" mass="119210" checksum="90B65A37FEA5AFC8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIQ3</accession>
    <name>A0AA38NIQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMC oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_418306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793859">
        <property type="protein sequence ID" value="KAJ3780198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIQ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="157"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="243" mass="25826" checksum="02D31381E3656CC0" modified="2024-01-24" version="1">MTAALLSAAGVIGSHQIVLNSGIGDTTTLSQLGMKTLVNLTSVGRNLTDQPSISNEFLVNSDQTFDNLARNATLLNEVDEESNKSEMGLLVDTTGNQLSFCRVSKSLTDIYGDPSFGRSSPHLNMVPGVTQALAPILVSTSLDTFYLRLVSLQIMLSDDSAVETYIRESSSSTAHPASLGTAAMSAKDADYGVVELDSIMKGVDGLRVVDASVFPFITSAHTQVPTYVIAERAAALIKSAWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ28</accession>
    <name>A0AA38NJ28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal recognition particle, SRP19 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_368643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793660">
        <property type="protein sequence ID" value="KAJ3780753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ28"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="34288" checksum="6E5363DDB7FD15D1" modified="2024-01-24" version="1">MSRKTVLVEDEFDDDTDLPLPARPLLNTGAKGPLLQEIASDNDSEDDLDFNTSHRAGPASPSSQPQFRPDGASQFPKNTVTDITPYKSWTCIYPIYIDAKRPYGTGQRRVERAKSIWWPLSKDIAEATNRLGLGTLHEVSKAHPRDWENPGRVRVQWKKEGRLMNPAIKTKKQLLEMISLQIQHLKPENIPRPPYSTSPLTSGNVSAATPTINAAPSSNKGKAPATTKSKSPIAPQPKQMMGGRRLPVPPEPLLPLASRLSPYSPALPTGVLIDTVKAGMNATENNAGALGAPGAPSPFGAPGGPQKGKRKVVRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJS7</accession>
    <name>A0AA38NJS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GGU10DRAFT_409705</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="MU793511">
        <property type="protein sequence ID" value="KAJ3781953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJS7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="560"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="634"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3781953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="873" mass="99682" checksum="44CC8EBA8C304435" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJU9</accession>
    <name>A0AA38NJU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_366525</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="MU793551">
        <property type="protein sequence ID" value="KAJ3781504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJU9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="423"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3781504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="527" mass="58986" checksum="E429143D2CA4BE3C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK59</accession>
    <name>A0AA38NK59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_364828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793504">
        <property type="protein sequence ID" value="KAJ3782044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK59"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="38389" checksum="C972B9F30519143B" modified="2024-01-24" version="1">MSVPSQTSQLNVVMGAMTFGKEGTNGARVHDVKDVEAILDEFLKHGHTEIDSARVYAGGTSEELLGQIDWRSKGLKLETKLVARHDQPNSEEIYHTYQDMKKHLLKSLKALNTEQLEMWYLHSPDRLTSYEVTMKAVNDLYKEGYFKKFAISNYMAWEVAEIVGICKANGYIMPFAYQGIYNAVHRAAEPELFPCLRKFGISFYEFNPLGGGFFTGRYTSLDDKVEPGSRFDPEKAQGKNYRNRYWKEPYFKAMASIQAIADKNQLTMAEIALRWVSHHSLMKREHGDAILIGASSLEHIRQNLIDLEKGPLPLEVVKALDEAWELVKPYASKYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKK7</accession>
    <name>A0AA38NKK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_144400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKK7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="45249" checksum="6B0C9A7C88FFEA6E" modified="2024-01-24" version="1">MQTPHEDNPVPPKPKPKEFPDELVSSINESGKSMTMGAAIGSLPSTVRRIKVLSSAPPDKRKRGRTQTRPGKSVPLGKRRLNQIVSDTDSDSGDDSLHVATHRSKKMLASLNFRRSDVEQQREGRSDAASNAGPSTGATQRGRQRDRSVEIAPFADTCGEGSLGAFSRSSSPKNPKHPSSKTGKASLPTARKRKERSSDNARDSAEFSRIPAKVSRPAGTSRSESLESGVHVHNQDPPLHNQEVLKVMSLLVDTILHHRLAEPGDAPLSVQQACQPPQDSTSHHPMPPSQPTIVAFFSPFGSPYVVNPPFPVGSLYSNNMPLNQPIVNPHFPVGSMYSNNMPLNQPIVDPPSAVGSPHSNNIPLNQPIVNPRSSYPSRQGHAWSARNRGHAPNNLPRFPYNRHRNNHNYYGHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKS5</accession>
    <name>A0AA38NKS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein RAB5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_348189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKS5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="208" mass="22837" checksum="63818B1849D2E62D" modified="2024-01-24" version="1">MSKQFQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTVTLEDQTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQSASLEKARNWIRELQRQADPSIVIALCGNKSDLSARRQVPEEEAKKYAEEEGLMWAETSAKTGEGVSDIFTAIAKKLPLTAPPSARAGAARGTTGARSGVDLNKQPAGQNSNEPCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKT2</accession>
    <name>A0AA38NKT2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_389370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793438">
        <property type="protein sequence ID" value="KAJ3783079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51869" checksum="E7EAD27A68AC8328" modified="2024-01-24" version="1">MSPAQNLPFDVLSEIFKYLPNLYLVEEIEPEVVSPKTGPYILCPAKYPWSITRICSAWRAAAIYEPRLWSRVHLEVGQRQPSPGKVELLQVYLGRSRNCALSVSLHCTWIERAKDNALLSLLFTTVDRWQFLSLHVLAKSLPLFHDLGPFPMLETLHLYVAHQAKTPPLTNVNHIFQHAARLHTIRYRHSDDRSVFVMPLDQLKVYQGPTSSIPPELGCEWISNLHWCAFAANGRQPDWPSTEVTAPHMREFSIQERIQPMNTTAILNILTLPSLEILRVKASGRFHLCDAICGLLERSMCILTELCLDIPDLTAQYMDAILEQTPHVVKLRITGKKLLPDFWERWIYDPQTHASNPCILQQLEILDLGRCTFTPSTEIALLQMIQSRWEVPGKTTTREYFAGPAANSIVRLCTFQVPYKFQRTKRSQKKILRLWKEQGLDIQFGPGSQNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKY0</accession>
    <name>A0AA38NKY0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKY0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="1">
        <location>
            <begin position="94"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="304" mass="33976" checksum="4B3B9D8BAE3A842D" modified="2024-01-24" version="1">MSAGLQSIHIDTVTGWENDDLQLLRNLKRLSYCNALKTSVTSPKYRDYLRTQQDTADNAGPDLQLVWLKKMKKIMNQIDNSGAADKLWVVPFTNRSFRFLDLGCCPGGFSTYILKKNKESTSVGVSLDPAQGGHPYLLEEALRVRQTVIFADMTTFQLSDPEAVDPTPSHAQPPLIPVPNILFARDFDLVLLDAHHLRNQTGSTHDLLAISQVLLALLSIKFGGTIVMKLASSPDSQYSATMAFHGWICSLLRFRFTSLMLCINEVIPGLRRVWECLRQRNSGPRGSGKERLVVGDLDFIVDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLD2</accession>
    <name>A0AA38NLD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_239463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLD2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="102" mass="11809" checksum="9D3B5FF870B662E7" modified="2024-01-24" version="1" fragment="single">IVFLRAYYSVQPRKFYTPVTSLFLPSQSQTWTGMHLTGTVRRSLGINMALNVNSTYRRKLQIEQQRMEKKRRFAPLVLPNSLQKQVSYKSKAEVAATARENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMR9</accession>
    <name>A0AA38NMR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_154467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793299">
        <property type="protein sequence ID" value="KAJ3787084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMR9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="3">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="181" mass="20360" checksum="E13DB6317B83D708" modified="2024-01-24" version="1">MALERLRAQLSMNTDFFPQHTMGDNMIEGLAVGAMFESRRELSEKQVHRPTHAGISGTKSFGAQSVVLSGKYSDEDEGNIVIYTGTGGQRDVYRNPGPQVEDQSFDHPMNQYLLKSSLNKRPIRVIRGPSSSRYAPSWGYRYDGMYKVTAAYQDKDPESGYNVCKFRLERVPGQPPIPVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN07</accession>
    <name>A0AA38NN07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_426769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN07"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="287"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3787534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="542" mass="58899" checksum="A54848ED9CDEA2ED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN23</accession>
    <name>A0AA38NN23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="666" mass="72088" checksum="AE3CB287EBA00256" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNH9</accession>
    <name>A0AA38NNH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_391045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="MU793652">
        <property type="protein sequence ID" value="KAJ3780800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNH9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="95"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3780800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="593" mass="63253" checksum="923D9C1E5A5571B2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNR8</accession>
    <name>A0AA38NNR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_379671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793576">
        <property type="protein sequence ID" value="KAJ3781295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNR8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="334" mass="37021" checksum="EC16317BB9D9EABB" modified="2024-01-24" version="1">MSSHSSMLPNLISFPEDCYDHAKFNPRGPDDHFPVHSTLTGIYLSVWSFTPRTYSLRSNLFPTTVHDHNKDRQLVGLSNWAVFRDHLHSVARATGLTGYLLGTIVAPSPIVLTSPSPGGTTVPPLVAAPTLINARTPSLEEWELRDGRLAGIIYQNVKDPRSITLTELMTTHEMWTQLTNEFDTSSAAAQALAKEQIQQFRYSLGTPFEEYFPKYLWVIQNHGSQLHRDLKHVLIEYDMMVESALPSTSSTPIPNALAARSSTGGVVCDNCQRSGHIKKDCWAKGGGSEGKAPCWYNAPKGMEPFSKSVSAALTINVPVPNKHLRLRPTSFKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPC3</accession>
    <name>A0AA38NPC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_388562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPC3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="303" mass="33516" checksum="85A65F03FCE9DF15" modified="2024-01-24" version="1">MITGAEISIIHFVAGKIKSELSPDELKEKTEKILGDQQLVSLLGELYQLDAKQAKERNDQWDRAHNLIDTLETLQSSKYVLRFMNAHTAYSLAKSYKKNVIKSTTAAKLQAYKDDLRKRSSTEEAGRTTDKPTKEANSSNSHQAPARNNENVTPRYILRSSSGITFAYPRGTPENPTISCPVGSKPTIPEGCKYGSVVYYHDALMNDADLEEVNSEDDDLVTVIEIKDRPESAQHKSQASSSHHSEGSTSCETSIVNALKPMAETAHLVQDILKFASDIDDDDDQSGADGYDFGGLYDFEVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPD3</accession>
    <name>A0AA38NPD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_294549</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU793382">
        <property type="protein sequence ID" value="KAJ3784295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPD3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="120"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="420"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3784295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="483" mass="55433" checksum="50A556A24BF7733D" modified="2024-01-24" version="1">MYQPSPGSSSPVTSAPSPLQIPENTAQRTRPDDYVYFERSNAGFSSEAVARATAAKLKLVSYYKMAVDSAIERNARRIELETKLSQTLQPESKERELRKHSKMESQHLRLRRTKIKLTDFKTVKVIGKGAFGEVRLVQKVDTGKVYAMKTLQKSEMLKRDQLAHVRAERDVLAESTSPWVVQLFYSFQDPLYLYLIMEFLPGGDLMTMLMKYDVFSEDVTRFYMAECILAIEAVHNLGYIHRDIKPDNVLIDRFGHLKLSDFGLSTGLHKVSDGEIYKRFLEEEKTRNPARNSVQVNPINLTMSRDQIATWKANRRKLAYSTVGTPDYIAPEVFLMKGYGKECDWWSLGAIFFECLVGYAPFCSDNPGDTYKKIIDWPNYLFFPEEVFISPEGEDLIRSMMTWADSRLTANQIKSHTFFYGADWSSLRLIEPPFVPRLQSSTDTAYFPTDDFGNMPDQLEQVEGISAEKDLAFINFTFKRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPH4</accession>
    <name>A0AA38NPH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_270419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="323" mass="37199" checksum="9D81ECB240E8E4DC" modified="2024-01-24" version="1">MAPFTSHSVDDARIFSYFSSFPVRSCEPDALPTIQQALNDTVYSCTTPESKERKKAEYRHTNPAGNLFGLSFAMSEVDRLAYVVKFIEFLCIVDDVMEDLPFGEACIEHAILRQALYECYDNDQYGGRAAGLMKSFLRELRIELTGFDDPSTPLLLKTLDTSLRNRDSDDSEFMTLAEYIPYRKTNFDYDFVCQLLRWGMNIPPEVQDDPLARAYDKYIGVIVGLTNDYFSWAMERQETTDRIRNAVPVLMKEHSISETQAQILLKEVIVNEEKKAKKLRDNIMSQTKADEELKRYVTGMELFAAGYSFWCATCPRYHRPQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPK7</accession>
    <name>A0AA38NPK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_355003</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793343">
        <property type="protein sequence ID" value="KAJ3785405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPK7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3785405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="525" mass="57650" checksum="BE6CE536BA19C683" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQX7</accession>
    <name>A0AA38NQX7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_49103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="318" mass="32520" checksum="DBB58101A3A0B72E" modified="2024-01-24" version="1">MFLPFISRRSSKRPNKRAGGGGGGRGGGSSGSSSSSKGSSSSSGKGSSSSSGSALSGNKGSTASTSSTIYGSSRSITPYGNGAAKVITIPSGQLFSGRTAGGATRSQVFGTRTYGSGYPSISGRGVANRGFPFFFWPLVWGGAAGGTASYLHDENEYGLPDNSSRPGGILMTAAFQSNSTSSIFRILSDNTTISELITDIHANCSSHLTSNSASSPSSAISYNSSASDAPKPEQVVQYFRASTVSLTLDGYNNTAVFDSEGTADIPLPSGIDTTLLECMNSTIGVAVPLVDAGSIRWGTPSYGVIGLVWIVMFFMNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQZ0</accession>
    <name>A0AA38NQZ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_260500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58618" checksum="220FC23C355F2F29" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRY2</accession>
    <name>A0AA38NRY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_392240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRY2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="106" mass="12338" checksum="E05389BF33392889" modified="2024-01-24" version="1">MSVVSPSRLAKLTKLRCNIFQTVYNPTGIRTGAKYLRARLRGPAMMSYYPPTLNISRVARMYPELELVDEDEEQRLQDIEDRKKRGKGAPKKAKTKEDGRRNQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRY7</accession>
    <name>A0AA38NRY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_329586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="338" mass="37991" checksum="86DA006CB4C10285" modified="2024-01-24" version="1">MSSRKRKHVSRNKVFSNRMPEGDNATTDSALYVQAYEADIIRGPRGHVAALSLEVRNVEGERDVGSGLIRLGGDDISPNSLNDEWDDYTSKGPNLSNHEAVWVDRYDARLLLDPQTLSSPGTKVRQVDIAPSPSSPTGWSDLPSDAEDTFFLTADEIEDYRREKRRRLMERSRDERLKARMEEDGDEEEIWGGSDEEPEESQREIMRRTAKSIIASPNPAQLELRILANHGADARFAFLRGRWSRAWNTVKAHARVDKLEQEQKAASHFVGMGLVADYSDSDEGGEDDEAHTEETGKRQDRAMASTDSDDGTEVGAIQALRRARAKEWMASRKSNAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSK6</accession>
    <name>A0AA38NSK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_419427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="298" mass="33780" checksum="0F100B1EEFAC9C14" modified="2024-01-24" version="1">MPMRYSVLMSEIDIATRATVTALKSLNLDCCLVGSVACFAYGMSRTPNDIDMVVLTSRYTQERLKSFLVHLDARFYLIASKDPSATYRVLWFRLPGYHRSCKVDLLLPGIMNIPSVDPNRVVRIQDSMNVLNSPGYASSLTLSTDYPLMPFLPLLLLKLQAWQDHGESPKLFMRQKQPTDVRDIQELLAEQKYATAGTDVRKLRLVKSRYHKETTVEVQTKQPSLLQVETPYLPESFVQAGKTRVRKFIGMYPWSEKQWKILGFSKSDITDATIAAGKSAQGDIRSLEDMMSSLVIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTF9</accession>
    <name>A0AA38NTF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginine methyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_257688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RMT2" evidence="5">
        <location>
            <begin position="138"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3790790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="42253" checksum="B10AF53DFAB0ECDF" modified="2024-01-24" version="1">MDLERSESEETVHIFTRLGEYLIDSILHGESFDAIKRIVLEGAPLWYQNESEGMSALHAAAYVQNPELVQFLIDEGAIWNSVDNLRCTAADVALSFNNETIYTIIRNAGIRAEMLLALLSSRSETEGPSSLVIRSEDVTAAASTDAFLKSRLKFVKDKNGQEICVVKAGDEEIGVMMGWEQDIMQETVERLCGDHPSSENLKVLNIGFGLGMIDSLFQALPTRPVTHYIVEPHPDVLQHMKELGWYQKPGVRIIEGKWQDSVQKLLEVGGFDVVYTDTFSEDYNALRGFFEHLPDLVAGPESRFSFFNGLGATNVLFYDVYTHVAELHLADVGIDVSWKDVRISDDKNLDRWGKTREYFSLPSYRLPIGRMSKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTH5</accession>
    <name>A0AA38NTH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_131526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTH5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="121" mass="14053" checksum="12090A2A89B68F6E" modified="2024-01-24" version="1">MPFYQMLCISTHYNEYRHIKQLVTQTCNHIMNNGGVVRKIDSWGTFGLPQRMKRHAGYSNYGDYWALHFDTSPRTLQSLNKIMRQDPLVLRWTVLKLGAKVEDLASEGRKAIQGQEIDDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTP7</accession>
    <name>A0AA38NTP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_302070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="77"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="401"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3790883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="562" mass="62527" checksum="29C3A63A5EB2C167" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUA0</accession>
    <name>A0AA38NUA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_397938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUA0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3791156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="228" mass="25179" checksum="56F090A926C8CBCB" modified="2024-01-24" version="1">MDFSKFNAATSVVDWAKSDAYHNSFLIPNDEVLDFVVKNSVDQGLPDIAVSPAQGKFLNLIAQSIGAKRILEVGTLGGYSSIWMGRALPEDGVLITLEINEHHAKVAQENFTKAGLDDKCKVVIGPAYESMTSLQPRIPFDLVFIDADKRTYPKYFAEAKRLVKKGGIIIVDNVVRYGQVNDLSVSDIDTVGIRELLAYIKEDKEIEATTIATVGERAFDGFLYAIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYR3</accession>
    <name>A0AA38TYR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_304530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYR3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="221" mass="23916" checksum="7F077A78A4BFC3C3" modified="2024-01-24" version="1">MPQHPEVLWAQRSSSTTPEKNVIYLTVNLPDIKESSLKFGLSETSLQFSATAGDSSKGIDEKEYGFELEFFKEINATESTKRLNSRSLYLILRKKDMEEEYWPRLTKEKVKNSHIKTDFGKWVDEDEQDGEPAPNDDDMSGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGGMGDMDFEKMMAQMGSASGEGAGPADDDSDDDNDGPPPLEDAEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZ83</accession>
    <name>A0AA38TZ83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_18510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZ83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="203" mass="22264" checksum="3CB00A970C84FE6A" modified="2024-01-24" version="1">MNFASNDDTPILVAPRPVRLNCATYTILNRAPPIGLFESSLDASPRASSRSALPSEALEEFLSILKPSIFPPRSPVRSRRQASLPGLHQENPFSYKGRTRIETTAEELENTRSAQSSRNTGSPAEVLDGMTEFQMVDLENTSFRWFASNVLSSPISRTNTRNPFHRHATHPIVSSPRSFTPLLASSLSPAAIPLPLPSPDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZF8</accession>
    <name>A0AA38TZF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_305440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZF8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="46089" checksum="A06CF45BC204E8C8" modified="2024-01-24" version="1" fragment="single">MSIFTSPTAEDVNGSTLKIQSGHNVLARQPNGDVRSIKIDRDSTVAVGRLGSFHANELIGHPYGFSYEMVNKQLKVLPVRTLEEVEDTDATNELINDGEFVQPLTLEEIQTLKQSGVHASEIIKKQIEQHANYSLKTEYSKDKYKKRKEAKYSKSFTTIEPTIYNVCNYWFNKDQNRIRDIRPDTLSQILTMANIQPGGRYLAIDDASGLVVAAILDRLGGSGMLLTICDTDSPPAYPVVANMNFSPDMVQSVLISLNWANSEQEYVSVHAPVEVPVDEIRSDRQKTRLRKRKAAYDLLENTREELFGGEFEALVVASQYEPSGIIDRLVPYLAGSASIVAHSPHSQPLVDLQNKLRNTPGFLGPSLTEGWLRQYQVLPGRTHPTMNTSGSGGYILHAIKVYDDPTANSVIIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZQ6</accession>
    <name>A0AA38TZQ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_431137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZQ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF53">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="288" mass="32737" checksum="993AE0F07C80165C" modified="2024-01-24" version="1">MANRISTKIFIPHPAETDCSIVGVLEQLSEAKPCPGRRIALILHGAAGHKDYLFLKRLALRLPMDSFRFDFRGNHETAGIWKQGGLADDLEDLRTVVEFLKVHYGYVIDLVVGHSRGSIVSFRWICTSEEGANISGFVNASGRYRMKKLLEREDVKRWQQSMPTEGYHVWSPIVARKQVSFKIYPEDLATFANWDTSFVWDSFPASTDVLTIHGLSDNAVPSYDAIIYARALNERDPGTHSLHLMEDADHNFTGRQDEVVDIILEWWEKQKESTLKSGIWMSGIRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0C8</accession>
    <name>A0AA38U0C8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Di-sulfide bridge nucleocytoplasmic transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_425477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0C8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="204"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="408" mass="46017" checksum="91CD4881074C5145" modified="2024-01-24" version="1">MNSRIFHSPRSTEAPMDFQFTSRPNTTPAWKSGDDLSTPRKRTHDDMNPSSPTSSSSFGFGANRNIPFIFATPSRQASEPYSWAPPPSGSPANLFPPPSLTSEVKDVDMSDASPPKLEEYRESQSNNDRAVATGALRRVYRARHKTPRGKRLLTRGRDSEIDDDANASDDELEELNAWNQNTSNHYTLNLPPSSAPSSNTPYILLGYLQFFFNLSLILVFLYLLLQFILTVQRDVEHRISEYSMDSVQEIARCALQYRNNYCDNPAMLAPALVHQCGEWELCMNRDPTKIGRARIGAELIAEVVNGFVEPISWKTLTFTLASLSFLTVFINTLISLYRSRHREVHQTQPPLHFPLLNGAPYGTHQYAVHQSPATTPGWSRNWKGNEDDDQTPSARRRRLESGVSVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U590</accession>
    <name>A0AA38U590_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_372261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U590"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="92" mass="10239" checksum="8AC74B2B3ED01380" modified="2024-01-24" version="1">MSKMRATIRIYEDPKTFTSEDVWEGARESTMTAVKIYAVIGLLSMAAMTTYAWKYTGLSSALSSLSSFKSVECELVVFVVSVPPRFLPLFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8Y7</accession>
    <name>A0AA38K8Y7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_60051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793433">
        <property type="protein sequence ID" value="KAJ3783159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8Y7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="217" mass="24054" checksum="CF6768728768C6E2" modified="2024-01-24" version="1">MAGRTVFLREYKLVVVGGGGVGKSALTIQFIQSHFVDEYDPTIEDSYRKQCVIDDEVALLDVLDTAGQEEYGAMREQYMRTGEGFLLVYSITSRNSFEEISTFHQQILRVKDQDTFPVVVVANKCDLEYERQVGMNEGRDLARHFNCKFIETSAKVRINVDQAFTDLVREIRKYNKEQQTSGRMMSNGGGGGPPGTYAGKDSNDDGAGGCCGGCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAH9</accession>
    <name>A0AA38KAH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_420087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793318">
        <property type="protein sequence ID" value="KAJ3786279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAH9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="766" mass="83808" checksum="95FF8B34EDF1743F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBE0</accession>
    <name>A0AA38KBE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBE0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="566" mass="60404" checksum="AD7331CFDA39AEA8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC18</accession>
    <name>A0AA38KC18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GGU10DRAFT_413459</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="MU793622">
        <property type="protein sequence ID" value="KAJ3780958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC18"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="56"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="497"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="441"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ3780958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="633" mass="69703" checksum="F5F57AA14FDBDE7F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC42</accession>
    <name>A0AA38KC42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lung seven transmembrane receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_278198</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793605">
        <property type="protein sequence ID" value="KAJ3781093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041249757" evidence="9">
        <location>
            <begin position="20"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="254"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="486"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="527" mass="59084" checksum="DACE2F9FE792FD52" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCN5</accession>
    <name>A0AA38KCN5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_245151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794792">
        <property type="protein sequence ID" value="KAJ3779486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="89" mass="10319" checksum="B37B24AD4A1F9937" modified="2024-01-24" version="1" fragment="single">RLQQFRAEPARYQPMLVNTTIDKTNFHCTTSMLESPWNQALQFILAAHCAEIVDVCPDKLRFGLEPIDWQSVLKDKLYRMLLAITKAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCX1</accession>
    <name>A0AA38KCX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_76372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793463">
        <property type="protein sequence ID" value="KAJ3782638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="415" mass="48339" checksum="3453C05C21A5598A" modified="2024-01-24" version="1">MALYSPLSSAPAARWKQLLLTKKSLIASIIVIFSFLGLLELLLERGISSRILSSFSFTPNSSSSNQSPLSCSNLFEPSSFQHSTPRPTYSRKANATFLTLARNSDLAGVIHSMKQVEGRFNRDRHYPWVFLNDEPFTEEFIRCTSAVTSAKTHYGQIPRDQWVQPDFIDEERATKARKALSKMRGVFYADSVSYRNMCRFYSGFFYRQTLLHDFKYYWRVEPDINYRCEIEYDPFLYMEDNNKAYGFTISVPEQKETTPTLWDTSMEFFNQNPQYLHPNNAMRFASKDEGKTWTRCTYWTNFEIGDLDFFRGSEGYNKYFEHLETAGGFYYERWGDAPMHGIAISLLLDRERIHHFDDIAYEHTGWEQCPDPSTPAYERGRCSCDYGNSMAVKWKRYSCQADFDAALAVPRINTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD80</accession>
    <name>A0AA38KD80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_369533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793773">
        <property type="protein sequence ID" value="KAJ3780356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041253746" evidence="1">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="20402" checksum="FB8C82A1442F5407" modified="2024-01-24" version="1">MSPVFLHKLAILVCLGLLSLSRAGPVKAKNNECSSRSPPFDPKMPMGYAYYNTGKGKYVSHSEKYPIRIHSVPKPPHAGHLKCLVYDKKGYFSNPDLRLLYVPEGDLFTQNTAVNYVIKQGMKPKSTIMVSVSSTTNLLDTMVIPRHMEDVVEIDCPTEEEQESSIVAHMDSSWKCLTIVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDX2</accession>
    <name>A0AA38KDX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_379317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793534">
        <property type="protein sequence ID" value="KAJ3781676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDX2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="296" mass="33634" checksum="3DF89773585B9E14" modified="2024-01-24" version="1">MLCSSSRSAIPGSLLNWRNSVSKQLNRHLSHDLTNQHSSTDLSSLGQISFTSIADLRIHNSHPPINLLPRFDLSRLPSPSGHIYYHTPPGRPSICSELRFRTTGEDGQAQDWALPNKIPWALPIWRIVKNPILGPLKELLVEDGIVTPSFIERCERVFPEDFATVAPNRVIYGLRQPFPVHVCRNKTMLWIVSEEKVLDLNIGSSWLGHPHTRQKNHKGADPSSILPARISMRTGNTMAELDYREDKGYILRVVKEPPMASPYNHRSIYKGRYRPLRCYSLTTPDYLPVLEQLVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE79</accession>
    <name>A0AA38KE79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_364259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793489">
        <property type="protein sequence ID" value="KAJ3782246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041441997" evidence="1">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="169" mass="18883" checksum="FDBF13CC2555B8DC" modified="2024-01-24" version="1">MRFNPAYLFVLGSIPATLCLTLNVRSDMRSYVGPVETPETRAFHQDHGMHLLAARADRNAVHLKFMPGVEGNEKPPPKVLPLVTKLFMTWLGVPLIIPEFVNQLSEVLHNGELIFHFWGSGLERCKESSDGCSVIIGAVIERNQWITIHKGARYLYSTTTESLAVEPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEA6</accession>
    <name>A0AA38KEA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_387776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793354">
        <property type="protein sequence ID" value="KAJ3785053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEA6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="83"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="192" mass="20726" checksum="E5EB5968CBF6EA68" modified="2024-01-24" version="1">MSKDISHIGGNASDKIKNFLVDRRKLFAASGLAPKLETTFGDSVVAALKLSEISIHENELEPLSLEAIAVCKIRITQNMVNGHGTLHGGCSALLIDFCSSLATIALQMHTTGFPGLGFSETIHVVFHAPALLGEELRVVNKCTSAGEVVQSARTEIWSNTHHRLVVSGVHVTVKPQKPKERKPQKTITTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFG1</accession>
    <name>A0AA38KFG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_315638</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFG1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="215"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3784046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="312" mass="33539" checksum="4C1AEE15833A498C" modified="2024-01-24" version="1">MAAVKKGKTPQDFAIDFMMGGVSAAVSKTAAAPIERIKLLIQNQDEMIKQGRLSHPYKGISDAFKRTSADEGVLSLWRGNTANVIRYFPTQALNFAFKDYFKSLFGFKKNEGYWKWFAGNIASGAGAGASSLLFVYSLDYARTRLANDAKSAKGGGERQFNGLVDVYRKTIASDGVAGLYRGFVPSVVGIVVYRGLYFGLFDSLKPVVLVGPLEGSFLAAFALGWVVTNAAGMASYPLDTIRRRMMMTSGTGQKYKSMFDAGRQIVAKEGTTSLFKGAGANILRAVAGAGVLSLYDKAQELMFGKVYSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KG15</accession>
    <name>A0AA38KG15_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_141824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KG15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="70" mass="7765" checksum="D2AA2E2D611A0FF9" modified="2024-01-24" version="1" fragment="single">MSREMVSTATSHGSTATLSMPISDLERRLSTARCMDISTVTHKACLNEVSDTAMFLLHILFCLCLLLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGB3</accession>
    <name>A0AA38KGB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HCO3 transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_387369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793338">
        <property type="protein sequence ID" value="KAJ3785561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="49"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="223"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="574" mass="63431" checksum="2F3395FD4C2FC5F5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGF5</accession>
    <name>A0AA38KGF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="5" type="ORF">GGU10DRAFT_346980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGF5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="214"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="255" mass="28442" checksum="161FAE5B627F6E2B" modified="2024-01-24" version="1">MANERVRVRGLSIFRPIIYGNTATLLTGEERENVPAEHTHKWIVAVRSAAPAPGSDIVGGADNLGYFLKRVSFKLHDTYPNPTRNIDKPPFEVSETGWGEFEVTIKLHFIPESGEKALTIYHHLKLHPWSLSGEPDSIPPLEVAQKAGPVHSWQYDEIVFNDPYQNFLNVLTNNPPTPLPRASTNGRTIPFHIANPASLEASKGGVPEFTTLIVKDEAERLEKAKKTIIAEQEKTRAALIAKEKELEQLQKMLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGS5</accession>
    <name>A0AA38KGS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_174974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGS5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="220" mass="24663" checksum="1A94F72CF7E4A7B5" modified="2024-01-24" version="1">MLPTSLIRRSVIHQLRRPYNYRWNHTSQPSSGRRYFWTHLLAGVTGGLVVIGAGYTYYHFSGLKRVVDASKQLRVYLEQTKQSVVNKHPNEALNYLRQLVKSYVAVVPGSGFAVDKLFDSVGEIIEEHQKEASEILANAQAEVEGIVKQKDQLTNTELAARIMAVVGKHMNEIGKLGAKAGGPVLQPVIDRLPEKVDFTEKVDQSVGMLKTFFDKGKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHY4</accession>
    <name>A0AA38KHY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_285966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHY4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="261" mass="28707" checksum="7A8D6FAC08D6AE3A" modified="2024-01-24" version="1">MSELLNVGNCCFLCSQIDFLPTLCPFCQNQFCKNHIQHEAHSCSAANRTDPVESFTKLQRCTLDGCKNPSLNASRSSSIPTCKACQGSFCVEHREPASHRCSPIQGAPEPTRNETARALLAKNFTSNPSSKLPVKRRILAKPIDAAKLAQLRKLELMKLRQLASPLDSKLQKTTIPVDQRRFFKASMDSKPTRGLWVEKNVITGKAFDLLAAQFGIPNAETDKYQLSQVSGEAEQSGALLYDQPLADQVEDGGELVLSIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKB2</accession>
    <name>A0AA38KKB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_337555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794006">
        <property type="protein sequence ID" value="KAJ3779984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="330" mass="36734" checksum="CFC94227C30930D7" modified="2024-01-24" version="1">MYMWNPPLKFSSNLKRLFMSSILRMHLYTRQFRMDFSLSRNPSSKVLIRDSEGWYFAMNTAEVNPPSSSTSSSSWRENDLVSESEYRSQSSGSITDRQSVISDNPVSAPVSPAVSSAVSPPWESRPTTSEDVVRVLNETDAPIHLVEPKPSMSNTDSKPVDQAMQNSVLGAETFLETGFASPTGSDFQQKDPLDGSHDENGRSDDLGPRTWLVDVRNFFTRHNFVYALDCDGTKNPELNNDRFVTFRNDVLWTTFSSKSIAIAAGKFALSVGIFALARYQAPKQVRVGHKEQEVSKVAIDILLFVGAFTCVSIAFQLLSVIGELAVFVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKH6</accession>
    <name>A0AA38KKH6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793824">
        <property type="protein sequence ID" value="KAJ3780254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKH6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="997" mass="113924" checksum="3705A88BCFCFAB7A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL89</accession>
    <name>A0AA38KL89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_397429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793573">
        <property type="protein sequence ID" value="KAJ3781319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="277" mass="30249" checksum="10D26E96F6F98D6A" modified="2024-01-24" version="1">MIMQSVKLGYSFQHIRGPSRSHVIPSPVSDEQACEAIKASVDALPDGVKMFLNSGEFYDNNWGIGNLKLLSRFFANHPAYAEKTFLSVKGAMSASGPDGSLEGLRRSKLDLFELAQIDLKLPVETTMKNLVTLLKEGKFSHIGLSGCNANTLRKAHSLNISVLAYSPLGQGFLTGQIKSPADADIPEGDMRAKYDRLKAITMEKKLTPAQLCIGWVASLGPINTSSWIIASRTLENWNAGDVQLTQEDKKAVEEVISVNPVAGERYFGAALQMYLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLQ5</accession>
    <name>A0AA38KLQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_429713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793510">
        <property type="protein sequence ID" value="KAJ3781964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLQ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="285"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="412" mass="46391" checksum="928E08FA1D4CF0E4" modified="2024-01-24" version="1">MIDSSGQAYKKARRRYLNTTRNRNPDIEKDWTPFRAAEKHFKARFPPPDLTTVLDLATLDESRASEVTAGNWAGKPDAAQTRAFTTVSGSYGYTLPEIPGLILLPAFLCPEKQKELIKWSLVEHARRPNETNLDTHYLLPSEGIWNAYVRDGNTVIHPRQIETDAEYLKQDPGPRTLIDNIPANTSNFKSFNNVSKPPTPPSSNVQPASCSDLLPRLRWANIGWSYHWGTKQYDFSKGKIPIHHTIRDLCKSAVQSVDWKGVFALDTSDWGPHGADWMYWDENYEPDAGIVNFYQTKDTLMAHVDRSEVCATSPLVSISLGNAAIFLIGGLTRETEPVPILLRSGDVVIMSGPACRRAYHGVPRILENTLSPHLADIVDEPDWSIFKNYMDSTRININVRQVFPKEFDPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLS7</accession>
    <name>A0AA38KLS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_89973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793503">
        <property type="protein sequence ID" value="KAJ3782054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLS7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="219"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="335" mass="38337" checksum="A0DEE43F842923CB" modified="2024-01-24" version="1">MSFITRLFFKQKEEDYDTILSTLANNIRKRQQQLSEIRLRERRATLLVTLYTLAAWVLYVSLWYTDFLPNIRGRGAEQPAKKFVGALPVVLGPIVILFIRRIVQIWYSRKGDAEERTLQQLLKQQREKVEEIKKKTNYYSTRELLQRYDESSPAASPLQQRSSKPSQPPQPSQPPVTPQRKPIPPSNGTLTRSTVSPALMQQLNSPIQSTPPEPPRKQWLDKIVDVVLGDDDAARFALICEKCFSHNGLVKESVWEDTQYVCPKCKHFNPSKRSRKLNASPISISTQSPRMPDSPSSATSRSPVSQPLRHRSQPKSPLRQSPTGEEDESMMDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMB1</accession>
    <name>A0AA38KMB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794770">
        <property type="protein sequence ID" value="KAJ3779496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMB1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="205" mass="23940" checksum="8DA9223AAE77D6DC" modified="2024-01-24" version="1">MSTTSNDNETIQQRRKRILQAQAARQRAREEEIARQEAEFAAEMERIEAEERAAREAEEKRIAEEKQIEEENQWEAERKIAEEKRIAEEKRVVEEQRKQQEQLAEKRRQEESRRAEEAAAEAEDERVCSATYAKLVEENRVEREKAAKELERRQKKPVTKAQPVTVVIPPRTSGSKKKIFKSKSVISNDSDIEEKEVTPAPRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMQ4</accession>
    <name>A0AA38KMQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_420221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794011">
        <property type="protein sequence ID" value="KAJ3779976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6532" evidence="3">
        <location>
            <begin position="296"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3779976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="634" mass="68720" checksum="944024BE1A0BBB83" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMR5</accession>
    <name>A0AA38KMR5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_316911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793422">
        <property type="protein sequence ID" value="KAJ3783374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMR5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="247" mass="26384" checksum="CE19B19887DB8B61" modified="2024-01-24" version="1">MSSSNNIQDIPLPYGWTKQYHESGHPYYVDTKSDPPRSIWTHPYEDEQYLREHPDAREKVRPLSSQGLGSKKQSLNEEQTRRHSYNGQSSKAPIGRKKGFFSKLKDKAIGTKEEREAEKARMAQLQEQRRQQRLAQQQAYYSQAQYAPPPQQYGNRYGGNGGGYGYGTGMGGIGGRRTGGMGGMGMGGMALPLVGGMAGGLLLGEALDGFGGGGFGGGGFDNGGFNGGGFDGGGFDGGGFDNMGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN74</accession>
    <name>A0AA38KN74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GH16 beta-1,3-glucan recognition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_42124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793401">
        <property type="protein sequence ID" value="KAJ3783839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN74"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="282"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="598" mass="66182" checksum="502B141706FD055F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNL7</accession>
    <name>A0AA38KNL7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NGG1p interacting factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_413692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793632">
        <property type="protein sequence ID" value="KAJ3780906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNL7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="284" mass="30514" checksum="1D8536570BAD00E0" modified="2024-01-24" version="1">MSSAFLKAVSAAMERIAPLRLAESFDNVGLLLETPLKQIKRHRVMLTIDLTTAVVDESIAAEASLIVAYHPTIFGALKSFTLGNPLQASLLRCAAHGISVYCPHTALDCTWGGINDWLAEGVMGGRMAGTVRPLQTEKFSPTGDSDGALGRLVTLRTPATMEMIEKRVKDHLKLSQIQVGYATTNDGRKSSAMVETIAICAGSGGSVFARKEADVYFTGEMQHHEVLSAIAAGTNVILCGHTNTERGYLPILASKLEAQLDAADYPQPFDVVISTTDKHPLEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPC8</accession>
    <name>A0AA38KPC8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_387756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793353">
        <property type="protein sequence ID" value="KAJ3785099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPC8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="163" mass="19112" checksum="7B3EAFF2C47DB298" modified="2024-01-24" version="1">MPSYYPTHGSHVSHHHHEPVIYTSSHHSHGVPYATSGSQQYYSQPTYGGENVVYVPTHSSSHGHSHRSHHYNVAPTTGYATEDGHRHHRRSRHRSRNTYTDTRHLTFGERIRRFFGFGPKHHHYKHKSRNSSWGFLGRSRRRRYMDARTGAEVDRHGRPVYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPK6</accession>
    <name>A0AA38KPK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_355299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33575" checksum="E6BB5035E3816474" modified="2024-01-24" version="1">MLRQSTSSDVAPFTVTKGTEAFMIREARLDELVSIGWVAAEAFINDTMAHYLSSATKPMSITSKADLRALYDLYYFLYKACMIGGGRAVVALPTESSSGATKIAAAACWYPPGKRIKVFNALRSGILRCIRNWGLRGFMRVSEEYTSITHGVFERTFTAKAMGIPVSDVASKGRRNKRKTLLESDSWYLQLMFSSKQYEGRGLMSTLMREGFAYAHSVTPGIPITLDASSSRARDRYMHLGYELMEPQTMIGVQRVGSQGIAPSKNNHERIELTGVPYWCMVNWEPTKSLHWKEKDTSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPN6</accession>
    <name>A0AA38KPN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase endo-1,3,1,4-beta-D-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_422776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793342">
        <property type="protein sequence ID" value="KAJ3785444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="263" mass="28993" checksum="7F22602E73F55BFB" modified="2024-01-24" version="1">MSLCDDCIKGVRHKGSPEGQWETINGVESYVGTPTGDYQKDKVLLFLCDVFGPQLPNAQLLVDDFARNGFKTVAPDLFEKDGIPFDFLESEEKRRAFDRSSWFSRHTPAISRPLLDKVIAALKTQGVTTFAATGYCYGGRIVFDLAFENIISASIASHPSLLKVPDDFEKYLSVSSAPLLLNACTIDKQFPEPAQLQADAILGGDKFAPGYKREYFDGCRHGFAVRADLSDPTMKAGKEGAFKAAVAWLYHYGFGPEGEKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQH3</accession>
    <name>A0AA38KQH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_395091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793337">
        <property type="protein sequence ID" value="KAJ3785580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041483137" description="Hydrophobin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="109" mass="10693" checksum="8213153116D49103" modified="2024-01-24" version="1">MQFKLAFVTAALATLAVATPTPRTEPASSCSTGPVQCCNSVESASSGPVALLLGLLGIVLQDVNVNVGLTCSPITVIGASGSSCSAQAVCCDDNSHGGLISIGCVPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQU2</accession>
    <name>A0AA38KQU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="11" type="ORF">GGU10DRAFT_360261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793410">
        <property type="protein sequence ID" value="KAJ3783636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQU2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="9">
        <location>
            <begin position="54"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="10">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="354" mass="39943" checksum="4FEAF07E704E2F5F" modified="2024-01-24" version="1">MPPKTCALCENAKAILKRPKTGQQICKDCFFYVFETEVHNTITQANLFARGDRVAIGASGGKDSTVLAYVLKTLNERYHYGLHLFLLSIDEGITGYRDDSLETVKRNQQQYDMPLKILSYDELYGWTMDRIVSQIGKKNNCTFCGVFRRQALDRGAAMLNVDHIVTGHNADDIAETVLMNIMRGDIARLGRCTSIVTQGEDTIKRSKPFKYAYEKEIVMYAYFKKLDYFSTECIYSPDAYRGHARTFLKDLEAARPSAIIDIIHSGEAFEIREEIKATQKIQQTCKRCGYMSSNDLCKACTLLEGLERGMASSGITDRARKKLDAEGPLPENLRTIPFYQPPSGNPNPTITIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRX6</accession>
    <name>A0AA38KRX6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_385100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRX6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="206" mass="20272" checksum="1D39E45307BE82C1" modified="2024-01-24" version="1">MLAGVKAGATVTSSTLLTVTVSTSNETSATVPSLLAISMPASSETSTAVSSSSFLAISMLAGVKAGATVTSSTLLTVTVSTSNETSATVPSFLAISVLASSETSTTVSSSSFLAISMLAGVKAGATVTPSSLLAVTVAASFKASATTSTLLTVTVSARCKTSGAISSLLTIAMAASTKGPSALMAVSMSSLLELIQDENLVRIMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSF7</accession>
    <name>A0AA38KSF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_306051</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSF7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3788984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="548" mass="62445" checksum="9CAE464BB2D6DFFC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTC4</accession>
    <name>A0AA38KTC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_418323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793305">
        <property type="protein sequence ID" value="KAJ3786801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTC4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="191"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="365" mass="40573" checksum="E8123C496B058417" modified="2024-01-24" version="1">MSAQAIPTTVQNPIALDLSSSYGALIIAAYISCAMWGINVIQTYIYYWNNPNDPWPTKLLFYYLDVVQELLIDHTRIVDTAHKILVTKVPWFTLIQNWGRVSAILASPQEALHEAWVGSIIIVVVQLYYLRRLATFASRTRHVHTWYLWLIFIILAALAVLQVPYCVFSINKENIFIPINLDLKRVGLVAAAVVDVVIAVAMIMLLKDTDSVDGPRPRHSKRFSRTMSRLTVIIVNTGLVTAVVAIISLILDETASGTDFYTSIAQYPQCSIYFSAFLANLNARHFIRGPGEDTTVSNIEDIHFASVGTQNDTEVGSVGRHIVLSQIRSEGDSSGIETSHATNLEKYTRSDSGTLNQSDGNLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVB5</accession>
    <name>A0AA38KVB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_359896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793404">
        <property type="protein sequence ID" value="KAJ3783777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVB5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="609" mass="66531" checksum="7B858E4B9BB625BE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVE1</accession>
    <name>A0AA38KVE1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mismatched base pair and cruciform DNA recognition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_388691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVE1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="107" mass="11440" checksum="7FABBC177AA54223" modified="2024-01-24" version="1">MSSDQTTSSEPSKANGQYNSMMGTTKEFIGNVTGADSWTQDGKEQHAKGEAEHDAAQATEYAKGTYDRAGGKIDSVVGAVTGDKQQQMSGNMRHDKGQVQQEANKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVW0</accession>
    <name>A0AA38KVW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_399953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793361">
        <property type="protein sequence ID" value="KAJ3784857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="231" mass="26386" checksum="1A2272A8E4C62C81" modified="2024-01-24" version="1">MPLAVLEFVVSSSVFLSDFNAEPPRIRRAGRACDHCKFIKVRCIKPDESTYCKRCLDDNIDCIISKPRQRKRPPGPKRGAQKGRNASNYPAFNEERNWSSSNFDIGHPEAHVSTQPVERSMPDSTTMSPPNPTSTIDQGHYDKEYNAASMSSYSYGQSHDNYTQYAEPSYSNITDSWALEGNGNQPEASDEHSYPIYHSWDGPFTMHMPAQPYAHNNNFRQYWNHSYYANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW91</accession>
    <name>A0AA38KW91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_354207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW91"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="214"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="283" mass="32022" checksum="9710EA92F76BCDBE" modified="2024-01-24" version="1">MVIIDLTKLQCCCISTVRMNPQDLPPLPRIEDTELFMTVHTHHSLSTGPYAETTYRDSEGLAELGEKVLDLTVTDYLYRRKPVIDAQSIRKERRDILADETIIQWLNLYNLKAKLRAADPTILQDPQEMRKYFLAYVGAVFVSDDILTVQNWIVRLIDPHYTLNSQGFPSMPPQYNSPHPAPPQSSPPSFPPTYHPPASSMTSTSGAPPNLSWLTLSVVNQAAAQKRMRIHYQPTRVGADHSPTWTVQCFINDQERGVGTGKNQKLAKEEAARKAYIDMGWMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWS6</accession>
    <name>A0AA38KWS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mis12-Mtw1 protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_368403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793638">
        <property type="protein sequence ID" value="KAJ3780863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWS6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="637" mass="69986" checksum="6FB516FCB1775E24" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX38</accession>
    <name>A0AA38KX38_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_277639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793565">
        <property type="protein sequence ID" value="KAJ3781388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX38"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="992" mass="112967" checksum="384A6671DAD5576A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYL5</accession>
    <name>A0AA38KYL5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_359954</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="MU793405">
        <property type="protein sequence ID" value="KAJ3783758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYL5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000037">
        <property type="entry name" value="Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="463"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3783758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="694" mass="77827" checksum="3BDFCA9C2D5ED4D8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZJ6</accession>
    <name>A0AA38KZJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_375550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZJ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="195"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="355" mass="39476" checksum="DD9CDF4B3828440A" modified="2024-01-24" version="1">MSSNSSVLADSSEPAAIVINLMSTFGAVMVGSFLSSILWGISTFQVYLYFVTYYDSDSWKMKALIAFLWACDTANEVLIIKANFRVPILNWGDVSGINNQQLELMDHTVTEVLPFTQCRAGAGFMNVDFCRRPLLLYWSKAVNKGRWYMALLMLILSCWLMIGTIVYLIFGYGRFISTLSTQKEVALNMTLRAAAVVVDIAIAVNMIYLLRAQNSVLFKSSRRMVNRILLLSVNSSFVTAVFATTTLILLASQPQNLYYCIPELSLCTVYFSSLLANLNARNYIRGEQNTINTFSSINFHTGGISLQTIPRQQSTNGGSLTQGTKVSNMVIGVETSTAVRSDVTAFDQEDSLFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZP7</accession>
    <name>A0AA38KZP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_181696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="344" mass="37569" checksum="286DD21DDD73F76E" modified="2024-01-24" version="1">MPPAVAIIGSGITGLSVALALSRIYDVTIVARDLVGDNESHGWASPWAGAGWRPHIGTSDEDIEMQKASFRYMWKLAETNPECGLKRVKSIDYFDQVKDKSLVWYKDFMPGCRRLSSTELPEGVTLGFEFQTVVATPSIYLQWLKDRLSASGTTFVRKELSHISEIKDVVPQVDVVVNASGVGAKYLGGVEDELVEELRGQTMLVRTKETTVICRSGDLYAYSIPRLDGNAIIGGISQPGNTSTELDPALRTEILRRARLVTSPGAYPEKVEDLEIVQEIVGIRPGRIGGVRVEKEVLQTPPVVGMKVVHAYGVGGTGYKYSAGLSKRVADYVDDFIYGDGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZX9</accession>
    <name>A0AA38KZX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_266688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="84" mass="9652" checksum="6755D8F50BE5C9D3" modified="2024-01-24" version="1" fragment="single">IIDGRFYTECRHFHAMATHKQDCLRDNCVFSVRHTHSYCKSPNCIRMMAQPVQNPIRFSSMNCANCRARDGAYVGSCRTCADFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0D8</accession>
    <name>A0AA38L0D8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_385341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0D8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="132"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="341" mass="37818" checksum="158DB12FAAE17868" modified="2024-01-24" version="1">MSSYEKQRLANIAKNKKLLEQLGLDRPFFEPVDEPRKPKATTKKRKAEKIEDDDSATPRKKSSRTADTSSDQENSTLRRSTRNRGKAIDYSAEIVSEDYIPNAFKVGIRKIKNTGPLGREDGKRIHDPKKFGSIPGIEVGTWWETRQGCSTDSIHAPWVAGISGSPNGAYSVALSGGYDDDVDEGYAFTYTGSGLPRFQVVDCLFPQAVVSGGRDLKGTKTAPKNLRTAPQSSDQSFDNPFNAALKRSSETKKPVRVIRGFKSTSNYAPTEGYRYDGLYVVESAWMEKGLNPKGYLVCKYLFKRLPGQPPIPVRTSRTDKDDSKGAELEDDTESSDVEDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0J5</accession>
    <name>A0AA38L0J5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_346577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0J5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="2">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="2">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="406" mass="43552" checksum="0D495CC29BB317A4" modified="2024-01-24" version="1">MTDLSAFNITNFAGGSQNLRIVDDLSTNSSIEQKPIDSNSSDTTEAVAFEVSDDHSSNNDSLTVWTNATSALQILYPENSIDPARKPQGGAEFYAVPLDLSDSKNVTLEYSVFFPQGFDWVLGGKLPGLYGGHQGCSGGDAATDCFSTRLMWRKGGQGELYLYAPKDKQTDSLCNDSQSVCDAAYGLSVGRGSFVFAPGNWTKVRQTVILNTPGRQDGCFTLDVNGERVIDRTDVYYRGIPLPPSEPPSSTQINLGDNDSKKKETKTAGSHPHKTSTTASVSAHQTHPPSGASDGGFLDPGGLLGGILRRNWPVDQEVVISENTDDKQQSLGVVTSDTDTNADNNDDSDSSLGNALQGHPANSSSSQLPGFIGLFFSTFFGGHEKQYASPKDQLVWFKDFAMSKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1P1</accession>
    <name>A0AA38L1P1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_418218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793849">
        <property type="protein sequence ID" value="KAJ3780217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1P1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="175" mass="19733" checksum="84751A257A3AFFAA" modified="2024-01-24" version="1">MNGKEKDKDGEREDRDQKRVRLMDRNEEQEVNKEKDDEDEEATAFNPDLDFDIGNNYDDYNDAKDLERIFHLPQSHLTKAFTGPPLHSVPIHIHLPHMFLPTHKCDDNALWTRRVCGPCLFTAVKTALSGESMMMGGAMRDEGGPRCPICRALIQGWDGKGGGLVRTVVQVVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2H9</accession>
    <name>A0AA38L2H9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793917">
        <property type="protein sequence ID" value="KAJ3780100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2H9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23483" checksum="298F4CF49C36C29E" modified="2024-01-24" version="1">MSTTSSPARPARSPTPVQDQEEVELQAYLAAAHREAQEKWRRLREEKASGTVADERKIVEEKEVVEEDNEVEKEVIPKVEPRPCKVAIKMVAGVPRSREVIPIISIPKKRKVEPIVAESSRKKHKGNSAAIIIDSDSDSLPIPFPNACEHCVRGDQVCRPQPHAPNAVACDQCHVARQSCSFLRKVRKPRARSPPSEAETTGMKEEMREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3E7</accession>
    <name>A0AA38L3E7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine threonine phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_106750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793549">
        <property type="protein sequence ID" value="KAJ3781525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3E7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="95"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="504" mass="55386" checksum="FDA70C5A5A722707" modified="2024-01-24" version="1">MSISSKSESPPPSRSPSPEITVSPPSPTEESDVLANSTEVAIEPPVGSALKNEDPQRKHTDMGWPSHDFTYLLLSEEKASAELERLSTPRISFDGVHSASLQPHPEKHSQDRLIAEQWDLGERGSWRFRAVFDGHAAGDETVDYVFSTLPHKVRLALTALSDINVEAVSSLLRETIFAVDYSIKQGVLELFPSPDYIEQLSNEEIQEIVNDRSTSQGLGDKADATVPSLTGPTTLTKKYAGRGTNNMKITRAMRGTTVLIVLISPDGGMWTASLGDCQAVLGQKQTLTWTTTILSTNHNAAEPSEVARLKLEHPGEESVVENNRVLGLIAVTRAIGDYQFKLPSIYTKRVFALTVPGMNRPGHHAQMIQDCSLTPPYVSGMPDVNYVKLDGTKACLILCSDGLLDLYGGQDWQEKHVDIAELCKMWVELVGERIDSRSSIPSQSSEPSENLALCLLSQGLRGPTKTFTGNNWTDEEALNRKSSLLTLEFKDKWMDDTTVLVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3R8</accession>
    <name>A0AA38L3R8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_35977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3R8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="368" mass="40804" checksum="C4B33C772F4A9C22" modified="2024-01-24" version="1">MASDPQSTANQRIVEDLVSRLRRRQLVGSRATALETLLVLRQVVSRARFSNIDQLVNIIRSVGRRLVDAQPKEHSVGNTVRKVLHHIREEYHTANEQPAAESSFSIAKFVLQGQPRKQATIPSSESRVPLKENDPDDPDSFARVLKPVLMEAIQDVFDELETVYDNISKNAKDHIHSDEIILTLGMSKTVDSFLKAAAHYRNYTVIVAETAPSYGGREMAKSLSSAGISTFLVPDSSIYALMSRVNKVILGAHAILANGGMFATSGSLLAATAARSYSTPVVVCAGQFKLTPLWNLYHEYGALDFGDPSAVLCFDEGDLVDKVDVVNPYYDYVRPELLDVFITNYGDHPPSSIYRLLKETYDDEDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4U3</accession>
    <name>A0AA38L4U3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_358868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4U3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="52640" checksum="11034D6D0577FE21" modified="2024-01-24" version="1">MSDDLGGYGTPPITQPKPRVSRSQGNKTAGPSKPGPRSRQKPPSPHHEVIDVEDDQGDENELESALPVARQNHTIRDNLTQPQHKSAKGKGKARAQVPKANTNARGIGGADLPVVEESDHEMGGEIDATTSRSKKVLGEVIERRKYDELDRRFKREKQSREEVEQRCEDLTMQLEKIMRVRETEAEALMLAQKQQFEAEIAALERVNKELTTNLAKIEPLMRSGKTSVLQLLTREAADEENRKIENEVSVWRQRYEEAQGVMKEKDQLLKERAQREKELIFELEVEKKNFLTFKAKTQNGSARPKSDLLGSDKPQTLQLVRLYEDSTNLLIVGLKPQRSEYLNLDDWTATCVFTYISSNDASKHSLNFMLTCRWERPDPENDAPVKNKNELHEMMYYEPVELDREPEEFIERLQHMGTAFSFTRDQLALFLRTLYNTLDDALHVEDGEAVDEDGDVEIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4Z9</accession>
    <name>A0AA38L4Z9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_351969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4Z9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="553" mass="61036" checksum="4A3B814D66128A9B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5D2</accession>
    <name>A0AA38L5D2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_395369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5D2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="33718" checksum="6367566D940888ED" modified="2024-01-24" version="1">MSLNSLTLTRTYHRDTYPAISPTKPSLNQAGKTILITGGGSGIGFEIARSFAKAAASRIIIVGRRSSVLDAAVAKLRDEFKDSTAEFIPRQGDIGDDSSITALWDSLNSQNIFVNVLVLNAAHLYSNGPDTLRIDKGEFMAAFNVNVGGNFFMSSKFVNQPLHPKGQQLNLVNVSTAGIHMNPAPSQNTYSTSKAAFTALLGRIADEHPVEDVQIISFHPGALYSESASANFDKNLVNWDEMALPADYAVWAASPEAAWLHGRFVWAHWDVEELKSDKDILTRLEQETGFLKVGVQGLAEISMEAFMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5K3</accession>
    <name>A0AA38L5K3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_246625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793339">
        <property type="protein sequence ID" value="KAJ3785530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5K3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10150" checksum="47F0AB0DD7A59C8A" modified="2024-01-24" version="1" fragment="single">MNVMLTRCRRGMVVVSRRSFLEGVARDTLVGQLSAYWTTREGRNAWVNALDVMNSRVNLPGAPGSKVDPAIATARISICSRPSHFPHSRAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5T9</accession>
    <name>A0AA38L5T9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_287367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5T9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="35314" checksum="66F3B6B92F873F75" modified="2024-01-24" version="1">MASFWTLFKQFFPPASKWSPDEIPDLTGKVALVTGGNVGLGKETCKHLLIKGCTVWLAARSKSKAEQAIADLKKETGKEALFLELDLNDLKAVKESAEKFKSQNSALHILICNAGVMVPPIEQVTAQGYDLQFGVNALGHFFLIQKLLPLLKATSNSLAETRIVWVASSAQFYFKNPPVDYENLTDTPSRKKLGKQGLYTQSKFITVMLGIYLAKLLAEDQNSNVISIYLDPGNIHTELGRNFPPFVATLMAWTILHPVSKGVLTQLYAATSPEAAQYNGKYLRPWARLGEPHPQTKDEVEQKKMWDYCMAAIKDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6N5</accession>
    <name>A0AA38L6N5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_133794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6N5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="81383" checksum="25C2DB3A04D5D71C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC56</accession>
    <name>A0AA38NC56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_406502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793444">
        <property type="protein sequence ID" value="KAJ3782956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC56"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="542" mass="60912" checksum="7722D927E2327A25" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCI6</accession>
    <name>A0AA38NCI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_402288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793387">
        <property type="protein sequence ID" value="KAJ3784186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCI6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041269552" evidence="2">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="285" mass="29869" checksum="612DDF1446708248" modified="2024-01-24" version="1">MSLIRSFLGLSCRLDFSFASLWLSSSENSLADAASRFAYTRLFKLAPYLNPQPSSKRLRLGGTITTPNLTKPSHSIFGMASPPVPEKPTPQANDLSSTTCDFTACTTATAPSSLPLKMPSFTGSPTLEDALNPRLSKLTSPTSAPCIPMSISPSLPPNHLSSSALFGESNVTMVNEDEIPNNPSPCPSSPSSSPSSAQPLSPGISTSSQLPAQLTPGFLDVESSLYETARSSVPPSILPQGACNSSLTSTTLPESTSHCPPRKLTPSVRGSPSSLPQLMVHLPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCU5</accession>
    <name>A0AA38NCU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793353">
        <property type="protein sequence ID" value="KAJ3785116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCU5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37292" checksum="8312BB64B754F20E" modified="2024-01-24" version="1">MEITNWDSVLQFASGNMDLNLQEHDFSEYSTSSSTPNLQVPTPPHSTDGGGSPVCDDPSDHNVLVSISTTFYPGANLHSLPPDLALLSSDSVFFYVHSHIILAASDNSFLSLIPTSSSKEHSNNMVIHVPELSPVLNIILHIIYDKSCSHYSPSLETLSAAVNRLPSYGIDSKSRITPSTPIHTLLLSHAPLSPLEVYTLAAKHDLYDLAVPTSSHLLSFQLSTITDDIAEAIGPKYLRRMFFLHIGRSEALKRILLQPPHPHAPTPWCDFTNQKTLTRAWALASAYLAWDARPDISTGFLEAALAPLAEHLSCDLCKQGLNDRIKNLIVQWSVVKRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDQ8</accession>
    <name>A0AA38NDQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_138477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDQ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="111" mass="11786" checksum="5CA863378B518D6F" modified="2024-01-24" version="1">MPKAPSTSISKAATKSAKTKTSKDPKEKRPPSAYNIFVAEKMKSWKADNPGTNAKDAMKAVGAMWANAEENPNRGKPPKSKKAKTPKNTSNVPASSSQPASDENDVPSSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NE71</accession>
    <name>A0AA38NE71_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotide kinase 3 phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_409821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793270">
        <property type="protein sequence ID" value="KAJ3788776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NE71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="462" mass="51538" checksum="1D5E50A9DC1E3BBF" modified="2024-01-24" version="1">MSSSALQVGQSGLVFSGSIQRQLLIAIGSSTLLSKKRPAEDNDAPSMEGSKGHKVAKVHPFFSKSPKELKTTSAFQWHKPLGARGSCLYGTNLIPACSPKVAAFDLDGTLIKPSFGKGAVKKALKGSPPAWEWWKDKVPNTLKDLNSEGYSIVIISNQAIKGASLTTWKEKIGLIAAALPSVPFRILAAIAKDEYRKPMPGMWTELTKKFKDEGVEIDKTASFFVGDAAGRDNDFASTDRKWALNVDLPFFTPEEYFLKQPLQTKFKLDGFSVVDLPTLPLFSSDTPVIPDIRQREIVVLVGYPGVGKSTICQRYFVSQGYERINQDTLGTRPKCVAAVEKALQKDLSCVVDNTNRDVQTRKFYVDVARKFKVPIRCFVFSGTIELAWHNNLYRAFNQPPSTASQEEKRALVPYLAFTSFRDGYEEPTLSEGFSEIQTVNWVFEGTEEERKYWSMWLQIQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHA0</accession>
    <name>A0AA38NHA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_244998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793949">
        <property type="protein sequence ID" value="KAJ3780062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHA0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="93" mass="9848" checksum="A69C30A0DCF078D7" modified="2024-01-24" version="1" fragment="single">FLCGFCGQEAFPVIALEPGLIQDSIDGGEGTPTSMLSITGLSLKELEPHLAKTNQHLTENSNLQVTLQNGPRALVVTGPSRALHGLVVNSRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHF2</accession>
    <name>A0AA38NHF2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793744">
        <property type="protein sequence ID" value="KAJ3780422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHF2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="270" mass="29376" checksum="E5DDB360BDEE46D0" modified="2024-01-24" version="1">MSSPAAIVATSPVAVHLGYANSVTPPSQQAAFILQELPGVILDWDEQVFTITRLDTDDLTVSTEEMISCILASLAMSRRWRMEQGAPPRYDEKARTLGTCIPTTSTANFSIIHNGELWKSSQPITYDCIFSGAQITELTQSGAITGNIYADVKWAYPKPSRAIQSSDKDSGLLADFFAVHSTKSDQKVLLNGIFAAAKDAERNVAWRAKRNKAPKSLRGTQRYAETASSSVKAPSTTASVTEKMRMWRLRTGARSTEDIDSASEVAGPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHH7</accession>
    <name>A0AA38NHH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_415062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793674">
        <property type="protein sequence ID" value="KAJ3780677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Expansin-like EG45" evidence="1">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="188" mass="19029" checksum="045262F98829A11C" modified="2024-01-24" version="1">MAASLTAVKGYLQLPSGNSSFTQYSGCGSPACGVTATGFSAAINQLAFGSVPGLGAGDGCGRCFALTGAADPYSPAFTGPFNSIIVKVTDMCPVEGNEQWCGQTTSDPINSFGTEFHFDICEDTGGAAAFFPSGHTALTGTFTEVSCSEWSGSDGSDLWNGACISGESAAFWPDGVGCGNQGVCHCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NID7</accession>
    <name>A0AA38NID7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_360220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793409">
        <property type="protein sequence ID" value="KAJ3783662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NID7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3783662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="178" mass="20135" checksum="3700194C79007FBA" modified="2024-01-24" version="1">MFPTVSLTSRPLDLLYFCFFLIHIPASLLLDFQILYPSAYVPSFLLALRQWYIDFSADPLITGAVRGEINGNLSWLGCFAWLELLFQCPTFLLGIRGLWRGSHSIYVLLMAYGASTATTTLPCIFYILKEHSNMTTSQQLILLSSYIPFFVVPLLMAIDMGLRLYSIVLSADSKQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIJ0</accession>
    <name>A0AA38NIJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_315837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIJ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="242"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="560"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="692" mass="76122" checksum="E00D91885C506180" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJG0</accession>
    <name>A0AA38NJG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_193743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793337">
        <property type="protein sequence ID" value="KAJ3785597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJG0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="429"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="664" mass="74671" checksum="CBAB78B1D20439BF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJY5</accession>
    <name>A0AA38NJY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_276032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793492">
        <property type="protein sequence ID" value="KAJ3782208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJY5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="273"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="464" mass="52166" checksum="D48DB7FD4BE20C93" modified="2024-01-24" version="1">MRAVRSDPEAAWPPPISPDETDEERDTRLEQEREAKRVSDAIDLALNAERESKKKSVHGAKILLLGQAESGKSTILKNMQLHFSPTAFHAEAELWRPVIHLNLVRSANFILNLLSPRSHGTTSPTSNLLLDDTVRRLIFSLAPLKSVETSLTKRISGSASTIDNQFKSNSIDNPYAHYNPAKAPEIAVRSGAGWKGLLKFRRQSGAGSSPEDMQNRRIINACADDIVTLWRNPDVQEKLRQEEIYLKDQPGFFLEDVERITKEDYLPTPDDVLRARVSTIGPEEHRIPMESSLENGNGKDWIVYDVGGDRSQRAAWAQFFDTVTVIIFLAPVSAFNQALAEDETVNRLADSMKLWRMICTNKLLASVDLILLLNKIDILDAQLKAGVQFSKYVTSYRDKPNETEAVSKYLLDMFTALHKQHSPSKKRKMHPHLTCAIDTKATAVVITHIQELILIKTLSQTNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJZ2</accession>
    <name>A0AA38NJZ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793528">
        <property type="protein sequence ID" value="KAJ3781744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041397184" evidence="1">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="231" mass="26360" checksum="EABEDA83CDDCF439" modified="2024-01-24" version="1">MRIIFIFNTLVLSVLVLFSNLAATRPCRTSSLVHNSELEDRGMAYPSPPPPSSLPPPKVPDGAICFFALNHETTQKLNLKSNKNFILKNSKMKAQIDYKFKCGSSPKVIDRKPKDLLCVLKANHLFKKADMIYFENMIQDRSSPHPVKFCRNEMTIEPQLFNNEELNIEGYCYAPTGIQNMNGTELSWNIPWQNWGIRNWPTDNDERILPVQGIASYYASEAGMDLHNGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK78</accession>
    <name>A0AA38NK78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_297475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793460">
        <property type="protein sequence ID" value="KAJ3782673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="176" mass="20115" checksum="131B70157D8D0B4B" modified="2024-01-24" version="1">MADQKTSPTNVMKEPRIDKLVINISVGESGDRLTRASKVLEQLTGQTPVTSKARYTVRTFGIRRNEKIAVHVTIRGPKAEEILERGLKVKEYELRRRNFSETGNFGFGIQEHIDLGARYDPGIGIFGMDFFVVMGRPGARVARRKQKKARIGNQHRIKKEDTMAWFKQRFDGIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL40</accession>
    <name>A0AA38NL40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_377074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793391">
        <property type="protein sequence ID" value="KAJ3784083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL40"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="757" mass="84120" checksum="A88D2AF4292F8F2F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLM2</accession>
    <name>A0AA38NLM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xaa-Pro aminopeptidase P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_357820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="343"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="572"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="634" mass="70933" checksum="7800EB11CDC9A360" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLR5</accession>
    <name>A0AA38NLR5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_355833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793353">
        <property type="protein sequence ID" value="KAJ3785088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLR5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="195" mass="22553" checksum="C6F37EDF59FD7792" modified="2024-01-24" version="1">MPRIRQRKPEAKLPKSDDTPLIDIPEEEQRRLINESGVLHKISSDQRQSESTDSEYTLMDEILDTSMIIIPFCSLLILMDILIHNQYGRHASFKELFDGMKSRGPILALFIFYVHRHKRSSEIQSFLFLLSCAAGTRLMYLIALGSWLVNMRQCPPLATIWIYTVLELDLGPTVISLMVTACFVWWKGLQKYLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMF9</accession>
    <name>A0AA38NMF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_433604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="744"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="924" mass="102262" checksum="C34F0529E52CEB13" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMX1</accession>
    <name>A0AA38NMX1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_309304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="295" mass="31196" checksum="9005797D2F94CAE7" modified="2024-01-24" version="1">MPRKENPGPLSAQQQQDLVSEGIDNFELPKSLVTKIAKSAVPDNTKIQKEAILSLVKGSTVFINYLAATAHDVAQSKQHKSISASDVLKALEMIELGDLVDPLSAELQVYRDQVKPDKNGGGAARRASTASASVNGHTAASASTASKAKGKEKAYTSVSAADTGPSAAPVASAVGGVETLPPPFTSAPLIHRGEQADHNPLRGSNVAVDPQVEEPEDHRMEVDNEGHESVGADIQGDAEMDDVADEPEEEQDDPGEPSDVEDEGQDEEEEVQNVVAMEQEEIHDDARGAASEHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN36</accession>
    <name>A0AA38NN36_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_138338</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN36"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="359"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="308"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3787684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="47485" checksum="98E5550BBBA3AC91" modified="2024-01-24" version="1">MSPARDSTSGVQANQNTVYTLSLLSEYSHTLDSLPSDLSRNFADLRELDAVLSSSMASITQKITTLTQMIEEGSGKKEERLWLLTEIAEEAARLKPGGEDKIRVACQAADNLRNHANYLKALAENIPDLNASTLSRHTTYPHVAAKSFMPLAAFETTRRRRGGFGSLLTSATDPSPAKRKRLVKDDEPTSRKDRPNDSRNRNRARAKKIERPASPAESVLSVTSHQNGTFSRNNSSVNKRSRSSAQHRAGSPSRDDHFTNGHAYDQRQSSSSGVNGRRDFNVPPSASHPSLPLPYHVNSNGYNHLSGPASDWAPSHNQLEGPGMPVARPVHSGTPASISAAEPIVDLNDGDVDGDGEDKPYCICQRGSFGEMIACDEPTCEFEWFHLNCIGLTVAPEGAWICDSCTNNQVVKKNGKRSARGGKRKGGGNRAGGRAASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN41</accession>
    <name>A0AA38NN41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_255920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793874">
        <property type="protein sequence ID" value="KAJ3780170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN41"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="52" mass="5599" checksum="CE2FE1F30874C434" modified="2024-01-24" version="1" fragment="single">MMSTWNKFCFTGGLFEASVMLPGINNVPYRSLSVWAMGNLGCAGYSATLDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNC1</accession>
    <name>A0AA38NNC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793711">
        <property type="protein sequence ID" value="KAJ3780530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNC1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041268546" evidence="1">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="265" mass="29699" checksum="E6FF063A8B7D755E" modified="2024-01-24" version="1">MPLPSKLFFIILLISGLLTATYAAPLGREELQKIRAFLDEMREVTNAYISLLKGLLEKIDDRYKYTQEEMEGLSKSLPLSSNDHGLGLQNQTWGQVWRMAGPGKYKGHDKVDLIIKSLPATKPAAAVLGEVKALKLIGDLVDFGTNAQGQPTIIMKRKEGVQLYETEAYKKASGQKKGEMAKETARLGCSKSAEDAFHKGVWHNDNHMYNILVVEVRDESVKSVELVDYGEGSNYLVHGEARNPEYISKYYDWCIHLYGQPIGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNC7</accession>
    <name>A0AA38NNC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_380473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793701">
        <property type="protein sequence ID" value="KAJ3780560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNC7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="101" mass="10998" checksum="406263E18061FA9C" modified="2024-01-24" version="1">MTLFPAISEIVPASNSTGYGSGVKAVQLERITIEVPEAPDEVPSVGTVAVTQGCTRKGYTVLGSMMGLQRSFWQRSLHAIWVSLRSANKKEVPEHRTEPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNL6</accession>
    <name>A0AA38NNL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_393193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="156" mass="18106" checksum="39FDD2D7426C7200" modified="2024-01-24" version="1">MSLVVPEAHQQFQHILRLLNTNVDGKRKIMYALTEIKGVGRRYSNIVCKKADVDLNKRAGELNSDELERIVTIMQNPTQFKIPTWFLSRQKDIVDGKDYQILSNNVDSKLRDDLERLKKIRAHRGLRHYWGLRVRGQHTKTTGRRGKTVGVSKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNP5</accession>
    <name>A0AA38NNP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_344413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNP5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="187" mass="20749" checksum="3EBAF2AECFA753E4" modified="2024-01-24" version="1">MKSSSRPTSAIPHAYYAIFACYEPLLCLLGFIGASSDPKTTFEGQAPWPADSPPPAELSRAGLVTVIQLAHVCFLVGVINHFVLSAARKYLGSFPAIQEKIVFSLLTPLLIGDILHLYVTIWALGDDKWNFRTWSPMLWTTIGLGLTLMIPRVCWHLGIGRYVHSRDGYQQDDSSKDNSPKFCAPMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP54</accession>
    <name>A0AA38NP54_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_389332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793436">
        <property type="protein sequence ID" value="KAJ3783110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="503" mass="53914" checksum="6AAD1E22A33E2A8A" modified="2024-01-24" version="1">MPETFKVELDTPAYKGSVSCNTGLFINGKFVDAVEGGTIDVINPSTGKLLTKVAAATSKDVDIAVAAAKKAYKTSWGLKVPGAQRGELLMKLATLLEANIDEFAALECLNVGKPWSESRGFDMKLTLQTLKYYAGWADKVHGHTIETNEQKLAYTRHEPYGVVGQIIPWNYPLTMVSWKIGPALATGNVVVLKPSEITPLTALKFASLVQEAGFPPGVVNIIPGYGATAGTAISMHPDIRKIAFTGSTLTGRKIQEASAKSNLKVVTLELGGKSPNIIFDDADLDQAVKWAAIGIFSNSGQVCTAGSRIYVQEGIYDAFIKAFSEAAAGLNTKTGDPFSEGTIHGPVVSQTQFDRVMSHIDAAKAEGAIPFIGGERHSLTEGFFVKPTIFTNCTPDMKIVQEEVFGPVAAVVKFKTEDEAIEMANDTNYGLACAVFTENVSRAVRVSNALEAGMAWVNCNITTEYNVPFGGYKQSGYGRELGAYAIDTYTQVKAVHINVGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPP3</accession>
    <name>A0AA38NPP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High nitrogen upregulated cytochrome P450 monooxygenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_353206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="552" mass="62939" checksum="F1E969BF0638C78C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPV5</accession>
    <name>A0AA38NPV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_266126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPV5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="691" mass="76135" checksum="E7EDB8127160D8B1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ86</accession>
    <name>A0AA38NQ86_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_409458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ86"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="39253" checksum="38FE9D5CF625A39B" modified="2024-01-24" version="1">MKRPTTSHFRVRRQYSTILNTRSRKSIRPLAVGTVLSFGAFASYYFFFPDASRGAPTSKHEKLSPSHFTPCTITSSEPCGPNTRLLTLKIPPKFLPDSDEKRFSSIWSVFVKDDDIQVERPYTPLEGVDAEGRMRFWIKKYPHGEVSRWLHSKEVGDEIEIRGPLQTWLWKDDDVWDEVVMISGGTGIAPFYQLFHDIISQGVSPRTKFTLLHSSPSPSELPPSAILLSLSSFATENPKRFQFRVFVDTLDPTDEIDRLKVNVGRINRATLVSSIKEQISPSKWWMWPFKKSAELDIDLRKTLFLVCGPEPMITALSGPYGRNFSQGPVGGVLEELSATSSQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQA4</accession>
    <name>A0AA38NQA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQA4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="103" mass="11036" checksum="F6108E59137F1107" modified="2024-01-24" version="1">MPNMSSNSESLFANRHNKSTDPLGHSSPTSTLSGSPPSASTILSTSLRSLSHEASRTSLRGTFPSSNTSLIGTRKPAIRADPSMLTCFDPADKELYDLWAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR78</accession>
    <name>A0AA38NR78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GGU10DRAFT_329865</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase SWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="922"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="1443"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="118"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="595"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="834"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1648"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
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        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
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        <location>
            <begin position="865"/>
            <end position="875"/>
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        <location>
            <begin position="1648"/>
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        <location>
            <begin position="1683"/>
            <end position="1698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037570"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040599"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3789652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1721" mass="193600" checksum="9D31B20F58A9407A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRJ9</accession>
    <name>A0AA38NRJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_342436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRJ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="90" mass="9842" checksum="66DF155D38449448" modified="2024-01-24" version="1">MQSSGQVPTGATQAKERLYTQLAGSFGRMNRALVQTSNLCELLQTDLDAMRTFVGLDAAMLMTVAASLNVDPEEEYTEHTSVEQSIDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRL1</accession>
    <name>A0AA38NRL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_342516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRL1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="260" mass="30078" checksum="257EB2E09293F9A6" modified="2024-01-24" version="1">MVRSASMGSDSNGKHEQDHTLDEDVAKSLSMNEDEVDEGSKEVNGEEDEEEAEEYEIEEILKHGKGRFPKGRTGYYVKWKNYGPEHNSWIDELDAGNAQELIDTYWEKKNAQTSARKGRKSITTESPEPPKKRRKSVKEDDHDEEIYSSKKKRVSRKKSETVESQSAQEEGGEELVATENFMQRYMKLASWEKLIASIDTVEKPNDSDGLIVYFRLKKENKRVRLPAKICHEKFPQLMIGFYESNLKWKETEMDVDDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS19</accession>
    <name>A0AA38NS19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_425206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="214"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="637"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="814" mass="91337" checksum="FC04E085D003472A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS29</accession>
    <name>A0AA38NS29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_341483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041291416" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="35076" checksum="2FE6250AA5C46DEA" modified="2024-01-24" version="1">MKCSIIIRSLLGLLTTTFVAATPNPIAGSDTVVVRDPSIWYNSGLGKYFVFSTDDNIAIWTSSAITGPWTNVGSVLPSCSIIDLPGNCNLWAPDINFIDGLYTLYYAISSLGSQNSAIGVATSPSMMPGTWTDLGEVISSVTGDVFNAIDPNIIDDTVGLQLTFGSYWDGIYQVGLYPGVNDQASPTPGTHLAGYSGRPAEAGFVYKPSSQPYYYGFFSDGITPLIGATSRPPAGEEYKVLVGRGADGQGPFYDELGNEITLDLNPPTGTLVLGSHDNVYAPGGQSIFADPVSGRDVIVYHYVKLSDPIGGPSYLGINYLDFSSGWPVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT05</accession>
    <name>A0AA38NT05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_145521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT05"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="279" mass="30889" checksum="3A15DBB3E64A5B03" modified="2024-01-24" version="1">MAPTVDDLRSQYENSLLAVAQSMRDAAEAAELFANAIVNTPMINGHGKEKGTTREEDAADGKRKRAKKDPLAPKRPASSFFLFQNQIRPKVKEQHPNLPSHELRKLLAEQWNTLPEEQKNHFKQMADELKVVYGEQKEKYKARSPEEVAAAAAAAAATKKTPKARKPATTSTTTPVIAKKSVVPHVSGSEGSENESLEDEKLETKSGKSVKAAATSSRKALKSELVVASDEDEDDEDEEGNQAKDSSEEEEEEEEEEEEQPPAKKVKSKHYDKPVSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT49</accession>
    <name>A0AA38NT49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_339895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT49"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="14"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="362" mass="38964" checksum="8693FDA2270C8D86" modified="2024-01-24" version="1">MAQVINRACILTKALSVEVKNVTMPAVGPEDVMVKVESTGICGSDLHLYNHFGFGKATMKNPNILGHESAGSVVEVGINVTGIAIGDRVCIEPTMYCRKCHNCKIGKTNICRKFRQAGMEPTPGTLQQFYVCESDFVVKIPDTLSWEEAGCIQPLAIAVQLAKRARFAAGQTVAVFGCGPLGALVMATARAYGVSRIIAIDISQKRVDFAKSMWADYSFISPQQEVDQDYPDWAETFKTQVIKDASLDPWGVDIAVEASGAEPCMHAGIAFVHPGGTYVQAGLGRSINSFPTVEIVAKELDVIGSVRYTAGCFQTAIDLVASGKVNLKPLITAVFPLSRSGEALEAVRKGDDLKVIIMNQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT84</accession>
    <name>A0AA38NT84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_128950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="104"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="325" mass="36754" checksum="04344E76ED3E9C8C" modified="2024-01-24" version="1">MYSHRQEHKPSVGATRRRKLLLSYAPDWIITILLGVIFFLIERVHGFWRDFSLEDTSLRHPYAVHERVPTFALVLVCFIAPLLIQPIINFITIRSWWDLHNSTLGLILSLAMAGVITQFTKITVGRPRPDVIDRCQPRAGSVDPTFGLSTAAVCTQTDMSLLKDGFRSFPSGHSSLSFAGLGFLAFYLAGKLHLFDHKGYLGKVWLFLAPFSGATLVAISRTMDYRHHWQDVLVGSILGTVMAYFSYRQYYPSLSSELCHQPYSPRIAREPEILPMHHRHQHSETSALPPPDGTVPRSDPGSLTELWGTNARNETSEYRSESRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU88</accession>
    <name>A0AA38NU88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_256761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU88"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3791237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="133" mass="14161" checksum="3024316E5D398C8D" modified="2024-01-24" version="1">MFDRQVSKPALSLGSLLTIPTVHGGLILSMTDTLGSLAVASKGYWMTGVSTDIGTSFVRPAGRPGDILHVKAMLTALGKSLAYTRVEFTNPAGELVAYGYHTKYVGKSSTHQKNIKLSDDGEMVLEGKDSDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUE1</accession>
    <name>A0AA38NUE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_430487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUE1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3791258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23270" checksum="E484F8F25922DE61" modified="2024-01-24" version="1">MNPITLELLRLTVDKSFHLAAPAFTTLRQTVKAAGVKEQYYGLTDDNSSQLLWIIEWPQKTHSPELHEESSHFRQQINVLDVNLKPISWLVPFRFAEEVRPALTAPICEFAHIVLKESSKSGMISESLHKTFTDCYYARGFTGGNWGIATNSNDKVCIYVLGWESRAHHAEYSKSALFDVEINKLKPHYAPGSMGIFSRLTRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1N0</accession>
    <name>A0AA38U1N0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_338371</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000066">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="868"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="979"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="79"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="423"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="754"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3791277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1324" mass="144374" checksum="F4E7AAC9746B1AA7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U574</accession>
    <name>A0AA38U574_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_425745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U574"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="422"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="678" mass="73679" checksum="8960B5D8AB4CDD57" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U5R6</accession>
    <name>A0AA38U5R6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_342856</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U5R6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="502" mass="56471" checksum="256DF964F26A83C5" modified="2024-01-24" version="1">MLASVSVLGKRKTSASKSKGYVLHLNSSPEPQTGLSESEHEPVSSSKKPVLVNGQSVEGNAKKRYYCTVEGCGKVYSKPSRLEEHSRSHTGIRPYTCTTCQKSYLRENHLQAHARTHLPASERPFICSLPKCEKRFWTQQHLRAHADWHKGVKTFPCPEPDCNEDFAKHHQLRSHICSVHSPSGTKPYPCSHEGCTKSFDTSQHLRTHLRVHNDKRYTCVNKACLPTAVHPIIFYPTWTALQHHTRTAHPPTCTRATCNGREFASQKSLRAHQKIHEQRDEEAQLDAIIAGSDGEDEPPSKKRRGGEHGRDWKCEMAGCEKDFKSSKALRVHHAVCHLGRRDFKCPRETCGATFGYKHLLQRHVARLHSKNSDNSSTDKDDVNQTAGFGSDVTASESELDSEPIATKPIMGIGAITGSAYSNRAQELLDTTKAVRCPYPHLQELTLVRSEVPDGKVIEPDSLQCDYIFRRAYDLRRHLRAVHEVEVEKESADAWVSKIKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7X5</accession>
    <name>A0AA38K7X5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_368209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793623">
        <property type="protein sequence ID" value="KAJ3780954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7X5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="167"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="333" mass="36567" checksum="1D03BCD6760B592D" modified="2024-01-24" version="1">MAYDATLGALEIGVLVAGVLFGVITAQVYIHHKSFPRESLWIKHGLVDFMWIIELGHTICVFHAIYFYTVTRFGDADALAVLPASIGAAVVLHGIVLLIVQGFFTYRIALFSGKPYIVPVLSGILIFCQMLAVYVLSAQLITVATKSLREFMDKWEWLMFTVLILRAIADVLISGSLVYHLVRCRHGTFKSTVAVVDKLILWSIETGIVTSMLGFLSIILYLTLKTTYAWLALLMFIPKVFSNAMLANMNSRVELQNMSRSVVDSTGVFTTGAFAAVPFGPVSVSADTSEIRSDVEDSSNEIYWASTMEQGADHKLPELTASGESSESGTVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8H7</accession>
    <name>A0AA38K8H7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_319307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793506">
        <property type="protein sequence ID" value="KAJ3782019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8H7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="99" mass="11054" checksum="492B645EC64A5758" modified="2024-01-24" version="1">MLTSTHHYLHLKLQPKITSELSIRQSIHQALLDFFGITGGSIHLDILWISDDGSEIVVRVDPRDARNVLAAATSLSSPKIQLVKESHFLPSLLSRNPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9W0</accession>
    <name>A0AA38K9W0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_293088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3784989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9W0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="897"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="10">
        <location>
            <begin position="778"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="8">
        <location>
            <begin position="919"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1188" mass="133401" checksum="D87CDC5CBC4B1FC2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB44</accession>
    <name>A0AA38KB44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_280492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794535">
        <property type="protein sequence ID" value="KAJ3779608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB44"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="36885" checksum="8BF342DA781609FA" modified="2024-01-24" version="1" fragment="single">MYSIGQSKNAGKNAVEEALRLRKSCDASRARVAQLDAILTDTNAPLYEVAEAELELERLRPKFKKALAEVSQQERLLGVEGMAQYRHLVSSLFLQARMNALTVKTRLHEKLHARKFEFDRIERSFCRQQFNERKIVTHTEDSIKRRDPGIQCLARSYNELHKKMVDLVRTKRAPRNAVIPSEIDMKHLFKLDVDDNIWQDIGLDEMTDLEELPLWLCDEGVRKGIQAKLELDQCNKELHHLTHERKTLREWMAEEWDVLCTTIEDLDGGSNNKDLLYQLTESKQNLLHLCVRWDSALESLPVIRGLNTWEPTTEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBC6</accession>
    <name>A0AA38KBC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_420355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794023">
        <property type="protein sequence ID" value="KAJ3779968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="264" mass="29370" checksum="22106B2FF0B8A14B" modified="2024-01-24" version="1">MPSHMSTRRQGRTQVVPDSLIPKTQEEIHAKKKEKQAEKESMKVSTEMKKNNSKKRIASHLDQQKQKDSEQPLLCPDLTLPSPAVGPKSPPLLDDSLTENGPDTEIQAEIDAMINDADNLAMSSGPDSNVDMDDVDFAENEDEDEEVKRLEEELKKAKNKKANKILLRQDIDTMRVNAPSAPVRNLTQKRPSSESEAKSLSAKRAKQTDIGGLKANWKPLVYGNKTPSTSAFHEVSPEIEFEEIAGGEFEQDVAKEVVDAERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBT7</accession>
    <name>A0AA38KBT7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_279061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793688">
        <property type="protein sequence ID" value="KAJ3780613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBT7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="475" mass="53322" checksum="BF760195CB44698D" modified="2024-01-24" version="1">MLPVANLHLRELATATVEFFALRTPTNTPTHRPQDLDEERTLTPVHDPVSRLTRECASLRQRLDEADRRQSTCTCQGDSISTLHHPSMRKTIDETRRELVRTQAEMTKLQERCRLLEKTLFETREILKARDEELEKLKGNQAETRSLNASIDQEDDQTLNFGKEDDNHPGSSLDENRALLKTTEVFMTRTDAWSGAQVLQAIHDLNSEILQFSAAATELCTFGNTTSSKVAIQATQDTASRLGPSIVRILSGRDHSQDPILVQLALQGCISTCVARALSVFCMGFPTKADAVLTQIYSHMYAAEPQPTSSRWRALTHRHIHTMYPYLSDYSANELAETMYRWSADILVVAGCQGYGKGSLGSRDGLRARFGEQVRRITKTACKLAQVTKEEIMSTCFEIIAIEHGDVFDPRRMFDSFGEYGTSRGSIITTTELGLRCKTRRSGEIAGIDDFATEIRMLMPPKVVLDSVLDFVDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBU1</accession>
    <name>A0AA38KBU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_337020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793684">
        <property type="protein sequence ID" value="KAJ3780628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="561" mass="61604" checksum="2EFE292BC2C9048F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCN9</accession>
    <name>A0AA38KCN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_408860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793491">
        <property type="protein sequence ID" value="KAJ3782218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCN9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="504"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="643" mass="72688" checksum="4120399AD662D08E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDH3</accession>
    <name>A0AA38KDH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_278671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793649">
        <property type="protein sequence ID" value="KAJ3780821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="592"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="97"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="746" mass="85048" checksum="ED73A13CC50FA765" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE73</accession>
    <name>A0AA38KE73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Origin recognition complex subunit 5 C-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_14804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793360">
        <property type="protein sequence ID" value="KAJ3784888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE73"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC5 lid" evidence="6">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="5">
        <location>
            <begin position="382"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="564" mass="62810" checksum="7725893AB43BD0FA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF78</accession>
    <name>A0AA38KF78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_177105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF78"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="314"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="499" mass="55271" checksum="370453E983AC8CFE" modified="2024-01-24" version="1">MSSSETRVTFGRAPGGPSRRFGPLHRSSGPARSIMRRPKIYTRHLALAQANTSFTRAPQDISNTLQHSGRPSTAMKAISPVPHHRVHYVGSRRHGRSNVFAFSPTTTHPIRPSSRHNRHSSTSSSSSKSGRYSSHHHSSSLPGLSTTPQSHNHSHKRRHSDTHSFGSGSTGHGHRSTTAHGSHESEHRKRSSVDSPYPFATTPSQGIRISPRQHSGFVQDNVTSSRSISSPFHHSGSPFNLQGLGYALPSIPYAVHSPPSFTPSPPYNTYTDSAHFPGIADADLWTQSPSFAPPQSERIHLHSELVYGTGHMVQWNMMLDPQTAISAFSDPSSNMAIYSGVPALDPTTKDLLHSPACPGAAKIIIRPRQNNQALAQWMDKWGPLEIYSSSLTFENEITVYEVLHAVYSYFQVRLSNRAADEMVMESKQRILNARAKRIALEGQLADKAEWNRPPKRVDVLALWSAFGGFDVRYDQDGGYNKLDEPGWRVVELELRLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KF79</accession>
    <name>A0AA38KF79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_290640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KF79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041235438" description="mannan endo-1,4-beta-mannosidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="11">
        <location>
            <begin position="33"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="581" mass="62747" checksum="991DE7EB639F5D4E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFI6</accession>
    <name>A0AA38KFI6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_418815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFI6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="69"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="819" mass="94451" checksum="AAC06799C63052CB" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFN4</accession>
    <name>A0AA38KFN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_350434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFN4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="76044" checksum="252765854957CE34" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFQ9</accession>
    <name>A0AA38KFQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_435201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793374">
        <property type="protein sequence ID" value="KAJ3784496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFQ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="274" mass="30376" checksum="99B0A632F47C7ACE" modified="2024-01-24" version="1">MSRHASLAVNVEDILLGIDLKREKKRHATLFPSKLDLAADFRRQAIEEEDDLSTWEFHAPAQPFIKRRPRVTANAVISPAQQLARNYRLASSMSEAQQIAHRYRTGLKIDIDVETTSSDSTSRSSSTDPSTLVGSERDSWISFGGEETTLESNQQGGSPIEEPKLRHSDSRAGAVAKARVEALQEIRFASASGALVCPRKDCRATLANVNALSFHLSLHDIEKSKPHHCARCDQGFDTRQALNTHSCPFRSRSAPSSPIFATFQHVLTKITSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGH7</accession>
    <name>A0AA38KGH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromodomain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_412685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGH7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="64"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18447" checksum="F8BC0226D681E196" modified="2024-01-24" version="1">MSKLHWAPSQVFSYLNFAEYVNLKSARQDLELCFNNAIRYNQPESLIYNDAKDLVKLTTSEYERDSHKEEKTRWKNERRMLEEIQQATGGTDAMLAEVRQTMQGMQEQLYAKENKLRQLQMQLSQSQSQLSQTQSQLSQLERLHAEAVEDLDTGRGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGK3</accession>
    <name>A0AA38KGK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_411984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGK3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="115"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="534" mass="60064" checksum="9445918D25B0BF4C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KH54</accession>
    <name>A0AA38KH54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA breaking-rejoining enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_350429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KH54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF4">
        <property type="entry name" value="DNA ADENINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29815" checksum="D277A71DD2D578C4" modified="2024-01-24" version="1">MLALYFELDLSTSFHCAIWAVACMAFWGCRRLGELTIPSTNKFNLKYHVSRNTLITPTFHADNTPKAISFRIPWSKTTKEDGALVVATAQNSTLSTICPYRAFTLHLEHNNNLPDNFSLFGFLDEFGRPQHMVKSTFLLFCDRIWKAKGLAYVNGHSFRIGGAVELLIAGVSPEVVAAIGGWTSLAFLIYWRRFQDIIPTHILKAYTPQQVERLKYAMNFWSQCNFEQVQTQKHSLKNFKHTSLMVFSRQLSSSDIHRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHN5</accession>
    <name>A0AA38KHN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_347363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3787991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="259" mass="28134" checksum="EC2A1EEEC7EE3EB5" modified="2024-01-24" version="1">MDRTDLETYQVQLSQVEDALQAEPDNAELASLRTELQELISLTETALAQAAGAASLKVESSRKAASTPALAWSAGDECMAKYSADGIWYPARITSVAGSEQNRVYTVMFKGYDSTEQAKPSDLKPLPASYASTVSATKRKHETDEEKERKKKKNEKKLETRAAKAKEQNQKQATWQKFAKKSEKKGVHIAGVSGTSIFKTPDNPLGKVGVTGSGKGMTHVTQQSQFFPGILSSILGLASNTLVAQTIAHSFRPFLLHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKZ0</accession>
    <name>A0AA38KKZ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_336749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793621">
        <property type="protein sequence ID" value="KAJ3780959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKZ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="430" mass="48910" checksum="608A8E87C7F37AF7" modified="2024-01-24" version="1" fragment="single">MCRERYDSDIRDLARKAKKSEAAIRSAMGVMVKDPRSLNAWNVFQHYQRAEDGENYQREPGQSEAEYWGEIQRRYQELLALSEEEKDQTIAELIEWYNSKLDAYTAVECVQGVGKNRLRNLAKPFMDRARMVYETQELCVFGWAVDPLTSTTIQWGADPLFEAMHNQNVSNMTLQATDYGALIHVQHMRRKQESVLAPEKQSIIDRYSDNKTVVRSLISNLFVVLFNEASPDANITHMSWGDEFAKLCLDHKVCLHGWPDVKHVPGVPGENGLKEASALPVPSGRKILKARIRFWQSLSAEDAVDEEEPLLEDDDLVRFVPWDDDLADIPIVRGVPDLDNEEGLPLCLLKQSKLYRLRVQARGMDLNNTDSEDNDNDDKNQHEEGDEGVPASKSGKAHQKWDLGKGVFVSRVQKTASWRATEEGSSDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLI9</accession>
    <name>A0AA38KLI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_127075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793632">
        <property type="protein sequence ID" value="KAJ3780900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3780900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="491" mass="55114" checksum="29283BAD2B05451D" modified="2024-01-24" version="1">MSDYVPTIDDIRVKMCYICREEETFDEPSDPPRAWTHPCKCTLIAHEACLLSWIETAQAKPSGRDALKCPQCATQYEIVHNRGQFGFLQKSVWRMLTDANIIVGYLGRIVLILVPTTVLSVVGAGIYWMLTKYGAYAIHEFFGQELYDTFLTDNMSKWPWSAYINLPLIPIFLIASRFDTRAGFLPIVSALLEWPNHYDRGLQSLEWKATNIFPPSPYTVGFILLPLARLLYNRALKRVTKWVLGARIPPTDGEDENALMVVRVRGAAGDGEPPNDGNADGDQQNDVQAADQPEAEEPVAEHNPAEQTITIYASPLGRKLAGALLIPMIARHMGNTLLRLARRPGVFARYLRHILAIGPRSTPNRSWWDANQLSSISYGKAGTGSPGSSLSFGVGNYRWGFDKSGSTIFGSDVPWKDVLHALWGGSKAWAEFDPVWWRNTLGFGLFVVAKDALNLLHLWLVKRERETRRIKNRDFAGVDITELDLIERPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLS3</accession>
    <name>A0AA38KLS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_364810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793504">
        <property type="protein sequence ID" value="KAJ3782039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="97"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="252" mass="29118" checksum="C1010FFBD469E607" modified="2024-01-24" version="1">MDVERKPLDDTVIIRPFYSTDSEQVLNVYFTGLVSGVDSAGYFAVTRAFLHWAPMYLAYFLSVSGGGTLLLALRTDIQILGLAIVFLSCCFMFFVYYRIRNAFLGYYQDGLRHDMTDISQYYRQDHEKDGYPIRRFWVAEISSMTSESGYEVVGCVALDCSLNRDEPMIGELKRLFVLPTYRKRGIGTKLMQTVIAFAKEQNITSLRLETTNFQPVAREMYTRLGWYHHDTRDSDFEAGDMKMSFVEYLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLU1</accession>
    <name>A0AA38KLU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_364570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793498">
        <property type="protein sequence ID" value="KAJ3782114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="438" mass="49778" checksum="5B7602AED8D6D07A" modified="2024-01-24" version="1">MSAASSGKPFDLSNYYASLAFSYNELTLYHEAEAIATRALQLNPTSLRARYSRAMARLEIDDLSGAVADIDALFNVNGGKSFPGAKHIRKMLHELLEAKDGSSEITLSIRRVNFKDLSWPQPELPAAEPSEEDHHPRNEIAPGQYRNSLTCWGHNTKKKKCPHKDCIYSHAPNFNSIRDTEGRNVCLYFLVGCCVRNKSCRYRHSTDGLPTDIITKPSLDSVFTLQAQWWNDPARMEEVCELLKQRSARRRAEYEMRSKARVNESATQDEPKVENRSLRADSEEEEKDTQRPDTQTQIRGSDIQFKQLYTTKGRDEIMDEKTLSSSRKTSTAVFAKVQSVCSIVEEKAMKKEEQCQAEAANRAAKRDQSDQVDGLVTLKPKKDIRTRTPYYPESWTVKSFKKLTNCGFTDDDVADLMGFGVNPWDEHAHSVFAYADDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLW2</accession>
    <name>A0AA38KLW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_379530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793558">
        <property type="protein sequence ID" value="KAJ3781440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLW2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="104" mass="11220" checksum="A1AC8F22A5C892AA" modified="2024-01-24" version="1">MTMNYDLNTYVAVSLAPNSPYLNTPSSLSSIHPALTHVGQVGQLQDVQLVSVPKDDWNNIGDDILASLKGSEGVSSKGKGCNYMSYGKISPNFDLSLFPTVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM11</accession>
    <name>A0AA38KM11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_389850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="18542" checksum="602186F733775DEE" modified="2024-01-24" version="1">MIVLKTSDNETFTVERDVAERSVLIKNMLDDIGENSEQAIPLPNVNSSVLKKVLEYCEHHRGEPLPAADADTSQDDTRKRTTDISEWDQKFITVDQEMLFEIILAANYLDIKSLLDVGCKTVANMIKGKTPEEIRKLFNIVNDFTPEEEAQIKKENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPU7</accession>
    <name>A0AA38KPU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_83431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793484">
        <property type="protein sequence ID" value="KAJ3782316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPU7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="85" mass="9314" checksum="25543AD344F16737" modified="2024-01-24" version="1">MLKEQQDAVIVVAAVTEGCPLVDFIPGDHDHDVVVQGDKITIINTDVTGRIRIVKSESDFGPTALYYGVASHTRSSGQSRLVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ04</accession>
    <name>A0AA38KQ04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_184387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041260764" evidence="1">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="18267" checksum="EDFFF2EDB023A8F7" modified="2024-01-24" version="1">MLSLIRLLPALHLLVSILAVTVTAAPTVPEPGVQVVSFMLAQGLKPLAPQKYDEPWTSPSELDVGIQIGTGSWAYYASRNPSGMIRIMPGLDSTKGLVIGTVKMGEQQKQIYWNHFSKFEYSSKSRFLEEILRSIKHFDFEQDNVQKSFQDHMVEKVNQLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQJ3</accession>
    <name>A0AA38KQJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_375592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQJ3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="131" mass="14506" checksum="878C1DDDEC7D458B" modified="2024-01-24" version="1">MSATSSPTRPVHSPTPVLNEDDAELRAFLAAAKREAQEKWEKLRVTKTSGVVEKVITEGEEVVGVKVNVEKDIDDVIGEEEEVVPKVEPKPCKVVTKMIAGMPRGRDMIPVIPVLKKRRIKPMVAESSHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQP4</accession>
    <name>A0AA38KQP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_353795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQP4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="163"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="801" mass="89658" checksum="031B4FF159F90112" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR01</accession>
    <name>A0AA38KR01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_352646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR01"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03792">
        <property type="entry name" value="GT4_trehalose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="281"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="488"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="737" mass="81576" checksum="2E40FB587A355EA0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRQ1</accession>
    <name>A0AA38KRQ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_356803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRQ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052818">
        <property type="entry name" value="NEDD1_Spindle_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44414">
        <property type="entry name" value="PROTEIN NEDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44414:SF1">
        <property type="entry name" value="PROTEIN NEDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="824" mass="89452" checksum="90E7047EB5E6EC16" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSD3</accession>
    <name>A0AA38KSD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_434377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSD3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="720"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="765"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="573"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="825" mass="86391" checksum="0241CCFDD4F187E6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSL2</accession>
    <name>A0AA38KSL2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_252361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794728">
        <property type="protein sequence ID" value="KAJ3779517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSL2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="135" mass="15568" checksum="0E00DE35B97188B6" modified="2024-01-24" version="1" fragment="single">VIGKDILEQIWADMERTVLPSWIQQAPPKWGIPASGKLSADEYKVICSIHLVITLIRVWGYENEGGPQSRSFQMLLNFLDLVHSIHVLFLRETSTKLQVYYKTRMLKYLRTVLELFPDVTLASNHHLAVHIVNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSN6</accession>
    <name>A0AA38KSN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High mobility group box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_250483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3785976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="71" mass="8286" checksum="F82D25F2EC485BF6" modified="2024-01-24" version="1" fragment="single">IPRPRNAFILFRCDFVRQKKVPDHLEANHRNISRIVGSVWKKMSASQKAPWIAMANTEKKNHAEAHPGYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTL3</accession>
    <name>A0AA38KTL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_321445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793675">
        <property type="protein sequence ID" value="KAJ3780672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTL3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="194" mass="21669" checksum="0A7F6AC9FB623C19" modified="2024-01-24" version="1">MITGIYDHGAPESILSQTMRETQPAVHLECAHIVPDSTYFNVEKTKEKRYSASVLAVLKRFGYDVEPSNKVHSLLNIMTVSYDVHDAFDRLELWLEATVINRYRVFAAPKFLIPGGLPEFIEFTSSYPKLPLPSPDLLALHAVCAKVAHLSGAGEYIEQLDRNVEELCVLAADGQSFHTLEHALMRATPSIVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTU7</accession>
    <name>A0AA38KTU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_254947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793611">
        <property type="protein sequence ID" value="KAJ3781047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTU7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041329261" evidence="1">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="131" mass="13763" checksum="51BB7DAEC9092A1B" modified="2024-01-24" version="1" fragment="single">MRFILSLLSLFALATTAAVAQNAFISAPADMTEVSAGSTFNVTISQPDSNSSWKNVAIVIALLNCNEYSSGCLGPTEELGTVLYSGPYNPQFTTEPGTGGLPPHENFTLTVPSDFEKGQSQLGVALFDLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUQ1</accession>
    <name>A0AA38KUQ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase C-terminal-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_80180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793474">
        <property type="protein sequence ID" value="KAJ3782472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUQ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="234" mass="26903" checksum="82C46A10172232DC" modified="2024-01-24" version="1">MSDNPRITLYTAPTPNGFKVAVFLEELKNTYGFNYDVRPINVARGEQKEPWFIAINPNGRIPTIVDRVRNDFVVFETAAILIYLQQHYDTDNKFGWDPKDHPDEYSEMLQWMFFAHGGVGPMQGQLNHFRNAASEVVPYALNRYLNEVKRLYGVLDLRLGQDRDYLAGTGRGMYSIADMNVLPWLRIREHSGLDNLDEWPNVKRWCENTLTRVAWEVAGNVGRAGDTASLYRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUQ5</accession>
    <name>A0AA38KUQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_363634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793472">
        <property type="protein sequence ID" value="KAJ3782502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUQ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="200" mass="21952" checksum="ABDD2AC51816FA42" modified="2024-01-24" version="1">MSRFTQYAEDASRLPEVFQRIAYDADTQRYTFKDRKGALYQSTPGESYGKLSPLSDGTRADAWRYGDEHTGSKRPQISTSPNLSFHDILPPHAIVSAGSSESPTSSNSDSEYLSLSSLSPRAKFIEAARRSTMPKMQGVVNGLRRSVTLVKNQSGIPPTVPEKDEKVALLRSQSVMSNMTGKTSRSSVMTLVALADEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUS0</accession>
    <name>A0AA38KUS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_284916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUS0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="210" mass="24220" checksum="EA3BAF9FE186E799" modified="2024-01-24" version="1">MVFVRAHTSIPVPRPYEVLLDSCGRHYIVMEYIDACELTITWSSLSEDQQKDIITELGRYWNELRQIPATGPAVCAVDGGTVKDHQGREFGPFPSFQDFATLYGYFILRGKCDSSTEQILENFLAKEHRIVFTHCDLAPRNILVKDGRIASIIDWECAGWFPEYWEANQVEYSNGLEIPDFGDKFIKSILPGFENEQRLEYELSRHIFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVA9</accession>
    <name>A0AA38KVA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_295468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793405">
        <property type="protein sequence ID" value="KAJ3783747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVA9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="66" mass="7571" checksum="52B44C11D7BB5B20" modified="2024-01-24" version="1" fragment="single">IPAQTYIYNNVKNLEAELWSFDDFVKHNAWKWYGSASNNNPDITEVDRRRELGTTSIVEGIAEVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVC6</accession>
    <name>A0AA38KVC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_235317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU793401">
        <property type="protein sequence ID" value="KAJ3783852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="106" mass="11735" checksum="A4635A24D34B65B4" modified="2024-01-24" version="1" fragment="single">TNYQPFKLFEQKFTFDVDFSQLPSGPNGAPCFSPMDADGGMVSFHFSSLVSRVTRRDQVWIGYCDSQSPHDIKCIDGEACINNWTPASNSSNTVTSATGNCVRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWJ8</accession>
    <name>A0AA38KWJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_279372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793733">
        <property type="protein sequence ID" value="KAJ3780458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWJ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="79" mass="8845" checksum="BD9BABDFC5E65DB1" modified="2024-01-24" version="1">MSTTRCESYSFPWIFKDCQERTGQNRGEKITLPGALASVSKFIYVAVKDPHSGSGILTGFPFDRRPEKSSTLKRSFPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX12</accession>
    <name>A0AA38KX12_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_433514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041357378" evidence="1">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="182" mass="20689" checksum="7AFD616200301A4E" modified="2024-01-24" version="1">MILSLRSLCAAFLLWTSCSGIAMPVGVQDQDKSEGKSVKLDVSLVRKLNGLTLDYRTPFESKSDHSVFESTGSPSVRSHEQWFIQIGLSSQWQAISSPDGLLKVVRTKQSRVQQKRLVIGEVYFKSNEDRKRILDGLVEIKPGGKFEYTKQIIERLRSARVWTELGGYKEFESMYEQVEVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYP7</accession>
    <name>A0AA38KYP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_359324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793395">
        <property type="protein sequence ID" value="KAJ3783983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="234" mass="26010" checksum="BC7FC1F39BB1965F" modified="2024-01-24" version="1">MRTSMIYRSHGVFQGFSSRRQPTMITNAPMMLLVLYFVLSPLDMRVGAGLYGVMAAPAQGYSHVERTNMRTSFFRHSVPENLINTDLEREVESTITTDKDTSGLGSQYDVASSGTSKAVTSRLDAVTSCSMWINEIFQSLRTNIVDSWNSLFTVPLSSLSLGMVFNDVVPSGQSVLERAINDVYEASISDDNVRNSGIRTEDNVAKDKGAMYNKMEVTLDAVRKLLVLFDDILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZZ4</accession>
    <name>A0AA38KZZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_163755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZZ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="237" mass="27818" checksum="A2487506A1265272" modified="2024-01-24" version="1">MLRSLIPELKVHGSRALSIIYPMSVLMNGSAVAQRGYWKVNDAGEFRCNSAPQAPPAVQKLLKKFEALGSNPPHEASLYSRETIQKHVSADIRKYTQRDERDITLKDLRIARRLDFQTYVRTKLNELDPSTTRQHRKRMTLKFISHAVARWHSLTLKEKLDIASSVRQRRMDPDSSSIGPSRQSVIERRQIKRIKANKSINHQIRLLRVNKAWRKHIRKRYIYRKRREQQHSHSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0K2</accession>
    <name>A0AA38L0K2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_432443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0K2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68715" checksum="8E3CCCC181CA4713" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1N5</accession>
    <name>A0AA38L1N5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_279806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793882">
        <property type="protein sequence ID" value="KAJ3780157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1N5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="319" mass="35389" checksum="19523DE11213B05E" modified="2024-01-24" version="1">MSSSSSSQSSSHPSLLHPSSSLPSPPEPSPSPSQSQSQTQPQSEREPITYRLYTGEPDLPHIISLIASELSEPYVIYTFRYFLTQWPHLSFLAYTPESPTPIGVIVCKQSFHESSTTGYIAMLSVDKRYRKRGIASTLVKISMEAMKLDGVEEITLETEHDNAPALSLYESLGFIREKRLYRFYLNGKDAFRLVLGVPALEDELELENEDGEGIPSNSSNSWSPSSSLGSLSGSGRQDEMKMNAGTRMNTGTGTGMRWYTRRRPGALGPRRYRAIVVDGDDEDEGDEEGDEGYQDDEDEDGEENMDTKEEEEGIEDGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1N8</accession>
    <name>A0AA38L1N8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein heavy chain, N-terminal region 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_369850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793867">
        <property type="protein sequence ID" value="KAJ3780187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1N8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="3">
        <location>
            <begin position="240"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1164" mass="134118" checksum="416511F563470A4E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1Z5</accession>
    <name>A0AA38L1Z5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_124813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793617">
        <property type="protein sequence ID" value="KAJ3780997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1Z5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43900" checksum="A5D5FB9A2267DFE3" modified="2024-01-24" version="1">MSVLRKHVFARSVVLRQLPASLDVEQALSCVPHGRFHDITPRSKDVLAIKFLDSRSATQFTQKFLLSPRAPPLKDATIEYDEPSPLPVDILTAIGLRNASRVIRVSSNNVKDIPEDFIDELRKFGAIESIESDKRKAVIHFMSIDAAMKALDMLRTNKTYAGYSVYYGFDKKCDTPLPYPASSRTDLVLTGLPKGTTTSELLRRIQSGLPDLNREVVRSVVYDESNAKAFINFLEPAVAKIVFDSFNNAESSTGGVSVSWCRNASNPVSASLRMAVSAGASRTLTVSHLENVQQLRRVLKAARKLGTVINHPYTPSNIKTVNIEFADIFSAFKAIERIGKNMDSYPEFANTFISFATSTNKLKPLKIVRVQTISTPELQKGTQTQAAPNPSSSTTEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2S2</accession>
    <name>A0AA38L2S2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_378632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793479">
        <property type="protein sequence ID" value="KAJ3782377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2S2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="300" mass="34667" checksum="C43A60F79A561D72" modified="2024-01-24" version="1">MSSNTVSESRVKLSFLRRAGSSIQQADRIHRTNLPALAGWIKKLTLEDRMEKNWGIERRNAERREIQAMHVAGLSDTEGSPVASLYSITSEEWDSVRKSPTLFQRLKEWIPARYLGWMTQMNEAEMQAKLPSQTAVANPAADRANSKLMDPIVEHVEDPTAVTEVDIPHQLHEMAKYHRYLPLPIFTDNNLLYVRNHLSKIKTEKIRLPNTTEKISILLLSDILDQLNIREVSVNEGLTYAKFEQAAANYYRFETERDPDGHAGNRSTWTKSHFLFWTNRSDAEDTFPFWKPLELEMRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3Z2</accession>
    <name>A0AA38L3Z2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_297752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793470">
        <property type="protein sequence ID" value="KAJ3782530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3Z2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="486" mass="54571" checksum="793F4687702234BA" modified="2024-01-24" version="1">MVFDPSRPIMNPLGFEVFDVSSRTGFMPPRPPLGRLPAPWTVWEELLDDARRERLQPGDKLGLTTAEMAHSERWRAGVRQMPLLDMNDPETSTEHLRRAHLVLTFLMHFYIHTLPPTSSIVIPRPISIPLLQVAKILDLPPVITFSDTVLYNWKLGENFSDSDSLKSLNLSDIQCHTLFTNTRDEIAFYLCSARIELHGVQALNIMRSSMDEIFVGDSLAITRLTTYLTSLATVIDELKLLLLEVRKECDPEIYYNAVRPWFRGEDSDTYLVPGSGKKRRWIFEGAGDYTDLNMLPPDRELSGASAGQSSLIHALDVFLGVNHEQPNAPSFMKRMQRYMPRQHRRFLDHLGKNPRSLREFVLSASSRDSNDDRGLALKDAYNKAVMSLKEFRDSHMIIAALYIIGPARRAAEAAAASLAKVAAVQVEARAELKSLVNVQTGPGGTMPDPLNGITGTGGTDLVQFLKGVRNRTVRNLLPDEEYVQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5I0</accession>
    <name>A0AA38L5I0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_5264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5I0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="83271" checksum="7B698F19FEAD32BE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5M5</accession>
    <name>A0AA38L5M5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_193150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5M5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37781" checksum="C1CDF4F0B70718BC" modified="2024-01-24" version="1">MPISPISTCSSSATFSQLVSMLTRPLAMLYPAEAVSQLQVFLHANFNSMFSAQQSISPFTILLSPTSLPPTPIYAACLQAGIAWSDWIRALGNQVTYILVMDGSLTLRIGESGEPVTIWSEDPIQVPAISKTAQGIDIPVFPKRPSTLHSTRNLRASLEARSSLPISLPTLLPLSGPSMDVDDSLSDSDSDSDSTVSSSRFSEASSAESMTSVSSSSSPVSAATDLPYMATAKKTSVYVPPHKLAVTSFSMDTDSESIPSHRLLSRSQRRLARIAVDKTKTSVCQYTYQGGQTGVMTGGVMLGKPTLKSSTLAKPAPTDATSTRAPFRRSTRKRSEMVILGPDTPNWRRIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5P7</accession>
    <name>A0AA38L5P7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_387224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793333">
        <property type="protein sequence ID" value="KAJ3785725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5P7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041316204" evidence="1">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="33382" checksum="296E6F8DC1BBAEA0" modified="2024-01-24" version="1">MFCGILAVLSIFMLLAPLVCALPFLGGGDEVLDIFSRSGGGARNLKKFGENLPSLSSSTQTQRRASASNCTLLTEHEAKKLPGWQKIIEHADKLWGTGKRSIKTNDEHEPDYPAKICIADKIQISYQGAPSCMTENVTTDGLLSGTNGTASVSVTQGFSASSSFSLSESATIGVSQSYMTMLNFPEVASTMQDFATSVSITNYVSEYFTSSYDEMETVTLLVAVSDGHHCSVIESVTTCTIEGTGELQFIASGYIWFEYVDPVAGHYKYPVMLEDVLPDPASRSSYARFRGNTTAISRSSYQATCKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5W4</accession>
    <name>A0AA38L5W4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_311717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793323">
        <property type="protein sequence ID" value="KAJ3786085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5W4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="250" mass="28273" checksum="03510378E4CC1E96" modified="2024-01-24" version="1">MSTSTSSSNDVAGPSSTVSKGEFLTPHSSVVDAELEKLLSREASAFQREVEVERILKAFKLNPYDILDLDETATQDDIKRKYRQLSLFIHPDKTPHPRAPDAFDILKKAESELSEKAKRDELDALIAQARTLLVREMGWSGMNSKAIKELEASEEVVALGGVKVWRERVRAKTKELLIDEELRRRKALQLALANEGLEARKKDEEVASRKRKADEDKAWEANRDQRVDSWRSFANTSKKKKKSKTAPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6U1</accession>
    <name>A0AA38L6U1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcipressin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_263125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6U1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="243" mass="26758" checksum="EA140EC2C46E2923" modified="2024-01-24" version="1">MPSAPYKTFSALPQKPTNSLAITQVPKEFFHPAVLNVLREHFDLYGEVNQWAPLSAFGRILVVFTEEEAAEHAKRSCDPIVISATHDRPEATLRVFRADPNPIIPHYAFASASSYIPADNYLRPPALEKNFLISPPGSPPVDWEPIKEEPPNATPLAGDLMVALRKLKIQEHDREGNQGPETLIHPEDGGSGVGVYVEDCDSGAATANMEIDDEDWVYGQTAPARSKWKPVTAMPPMHATLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCB7</accession>
    <name>A0AA38NCB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_360729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793417">
        <property type="protein sequence ID" value="KAJ3783481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041328426" evidence="4">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="61"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="371" mass="39554" checksum="E18C9555A19D3A57" modified="2024-01-24" version="1">MFLTLVAVALSSSLFLTVNSQGIVCNVTSPCPESTPCCSEYGYCGTGNFCLGGCNPLYSNSLDSCLPNPLCEDATHTFADNSRILTNASYFDGNASEYDWVVDKGSIINTNSSGGELGLILTETNGGTRLSSTRYVHYGTISAQLKTGRWPGVVTAFITMSNIKDEIDWEFPGANTTTGQTNYYWQGVIPNATHGQTETGVSDTFANYHNYTIDWQPDALTFSIDGNVVRTIKQADAVDPTTGINEYPNTPSRIQLSLWPAGINSSAPGTVEWSGGMIDWQDPDYVSAGHFYALVQSVSVKCADPQSPGANITSYVYGSNQTTDTPAIAFSNQTTVNGAGHLFEIARFGGLGGKVVSWIVPALLGLAVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCH1</accession>
    <name>A0AA38NCH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_402560</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="407"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3784051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="617" mass="69915" checksum="8EF62387AAA80D2F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND28</accession>
    <name>A0AA38ND28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_186406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND28"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="37"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="226" mass="25364" checksum="06EA027802557CA0" modified="2024-01-24" version="1">MGQCFSDNGPLRLHNMTDHKEPEKDLTDNEIVRLFGLVAKELDKAGKNVTIVAIGGAVNTVLLHSRESTTDVDFFYTTKTENEDVHSVVEAAKKVSKSEKLGDQWLNNHTVLFIQEENMMILYNEACSQNREIFRAKGLTVLAAPWHYALTAKIDRLAKVGAKVHDLPDAVTYLHELVMVKRSLVSTADLADWARKYKCTQANNDLLRKINEAYVEKYGSQGIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NE91</accession>
    <name>A0AA38NE91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_372542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NE91"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="179"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3788941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="578" mass="62043" checksum="2344E6EF57813B79" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHI5</accession>
    <name>A0AA38NHI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_134493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793660">
        <property type="protein sequence ID" value="KAJ3780752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHI5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041294558" evidence="3">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="21746" checksum="BC8C37947F93371B" modified="2024-01-24" version="1">MRLLLTLAANTVIFIIFWCLSFTFAADPNAGAGPQNGTHQELICIPFGECEPCPLDELDKPFCQPFGNRRLMHCHNASFQSSSYYDGSYRPPRPRMLPPDRQHNPIPNLNSNSDHDSNSPHRPLDKIGETPAWESCGRIISRERADFYEFMACNVLFAIGAILVVYIRSRRLHALHARQLAARIGLIRNGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHJ4</accession>
    <name>A0AA38NHJ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_278564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793634">
        <property type="protein sequence ID" value="KAJ3780887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHJ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="240"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="585" mass="64855" checksum="A797682F097BF7A7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI37</accession>
    <name>A0AA38NI37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_389552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3 7"/>
    <dbReference type="EMBL" id="MU793451">
        <property type="protein sequence ID" value="KAJ3782822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI37"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000010">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="78"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="9">
        <location>
            <begin position="496"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3782822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="848" mass="93560" checksum="A583F2898466F91F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI71</accession>
    <name>A0AA38NI71_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_61065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793436">
        <property type="protein sequence ID" value="KAJ3783107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="288"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="668" mass="73695" checksum="9695DDEC94A342B2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJN8</accession>
    <name>A0AA38NJN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Telomere stability and silencing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_256095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJN8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041362429" evidence="10">
        <location>
            <begin position="22"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Sde2 ubiquitin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="12">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3785957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="253" mass="27011" checksum="8764D3EE8B125CA8" modified="2024-01-24" version="1" fragment="single">MITNVLVSSFVPFGTLTLAASSSTQISDILPLLSQKYPLLPSSGLILSFHTGIYSEDARLSSLCDDDSNLVSLRLSPRVLGGKGGFGSQLRAAGGRMSSQKTSNNDSCRDLSGRRLSTLKEAKKLAEYLESEPERLAAKADAQKAKLEALERRLGIDSSDAGPSKVTGSSPTEQPVKLAGKKHRFDDNEYIEQSRDLVDNVKSAVSAALLKKKKKAKLSPESDTPADAKSSKAKAPYKRTTPVVVTATATEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK51</accession>
    <name>A0AA38NK51_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dipeptidyl-peptidase V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_390166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="EMBL" id="MU793506">
        <property type="protein sequence ID" value="KAJ3782014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK51"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="10">
        <location>
            <begin position="53"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="481"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="634"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3782014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="719" mass="78552" checksum="33EF441D644280B7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKX9</accession>
    <name>A0AA38NKX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_403769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793406">
        <property type="protein sequence ID" value="KAJ3783738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="138" mass="14963" checksum="2923D9F10B540840" modified="2024-01-24" version="1" fragment="single">VKTAFFHSPAYAVVGASKDQTKYGTKVLQWYKAREMPVTPVHPKETELEGIAAVKSIEELPSPSTTSISIITPSKASLLGPITIDLLQKAKELNVPALWIQPGASDSACINFIKENDMVDKVIYGGSCVLIEGDSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLJ9</accession>
    <name>A0AA38NLJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_30458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793380">
        <property type="protein sequence ID" value="KAJ3784354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLJ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041302353" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="192" mass="21413" checksum="98F4B1727650050A" modified="2024-01-24" version="1">MHFNLAYLITVLFAISVYTAPVTNPSSCVDLDIRDESSFGCGHGHLTVRPRTANGPSQAQLDMLNRLNRMRHWNTITLGIYVTFMSDSGTAYEPPSSNLEGYPNIQKRISTAIYEHMSPSQTHRPILYLNRFKSNDPNPSAILVAFRLEGKTLWSLISIDKDGVPTVVAQTQASSLSFSLPLTLTFYCSRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLM7</accession>
    <name>A0AA38NLM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_356441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793360">
        <property type="protein sequence ID" value="KAJ3784878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="35255" checksum="209E06B7906B9041" modified="2024-01-24" version="1">MATLTTTLTATSRARRFSLSLISAKPSPLLNLPAELVLDILESVLLETKPSALSIISKVISRFVDIIIYRTVVLHSKESLTLFHRTTLSRSPGFFASHVKKLVVSYQPHNEVNYFRAQRVIAVCGGIRSLVLPMWFGTDCLASVMEGRTDGGLSEIIIQSPDGMIAPFECLHKNSQLADTISDSITHLRICEPGGGWTSPKEILHPFGALRNLTHLQLSRRANANSDNDLKFQEQVRSILQTRPALCVLAVVFYPQLWVADEDVRESDIWAMMREVAEQDGRLLLVQGKNDDWENQWRSTNSDAGRRFWAELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLR1</accession>
    <name>A0AA38NLR1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_333702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793366">
        <property type="protein sequence ID" value="KAJ3784714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLR1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041295571" evidence="2">
        <location>
            <begin position="24"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="574" mass="64497" checksum="971C4B5C010C3756" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM27</accession>
    <name>A0AA38NM27_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_394957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM27"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041392467" evidence="1">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="424" mass="47431" checksum="6A6566FA3382EB5F" modified="2024-01-24" version="1">MSSLILWHVSSSLSSHLEALHICLMLQVQNSYSYTKSDWAADISAAQAIGIDGFALNTAVDSYEQTKYPDAFAAAQAADFDLFISFDMTYEWETTDMVNLVKQYASSSNYYKWEGKPLVSTFGGDSDSNDFWTTFKTDLANAGISISLAPAFVDYREPDEATQMFSNFTAIDGFFNWWSWPADENANLTTDTDLAYKKALSSAGRSGPYIMSVSPWQFKELGDGQDWVEQCDTLWEYRWKQAIHDVEPDIVEILTWNDYGESHYISDINPIVNLGDLAPLYVNGFDHSGWRTMAKYYISWFKNGTAPAIEEDKVIYWYRVHPKSITCSQGALPRNSQFPEDAVFAFSMLKSAANISLTIGESTTTYDSGKGVAIGSVPFSQKDGQKPVIEIMRDGQTVKSGTGSKTINTTNCDYYNFNTFVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMJ4</accession>
    <name>A0AA38NMJ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_351124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793309">
        <property type="protein sequence ID" value="KAJ3786634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMJ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="89" mass="9437" checksum="E62851152B45BFF5" modified="2024-01-24" version="1">MGSICSKPSTHSGGHTVLGSISDNNNDASRTNEADPRAAAAEAAERRLKASQMRGTHSSNPNRGKLAAQASKPAKVTPEPEQEERLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNC4</accession>
    <name>A0AA38NNC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_142020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MU793704">
        <property type="protein sequence ID" value="KAJ3780545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="408"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="715"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1375"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="765"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1511" mass="168293" checksum="F6C8A74ED89F22B0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNU8</accession>
    <name>A0AA38NNU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_379469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="MU793550">
        <property type="protein sequence ID" value="KAJ3781520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNU8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="322" mass="36417" checksum="FBA156E5FDEBBD9C" modified="2024-01-24" version="1">MADSTSSATSGHVAIAQVNDPNYLVHDEYQYLDLIRRVLDTGDVRPDRTGTGTIALFAPQNLRFSLKNSTLPLLTTKRTFSRGIIEELLWFVHGCTDSTILSQKGVKIWDGNGSKSFLEGRGLGHRREGDLGPVYGFQWRHFGAEYKDCDGDYTGQGVDQLQECIQKIKENPTDRRIIMSAWNPKDLPLMALPPCHLLCQFYVHLPPLNSTQKPKLSCLMYQRSADLGLGIPFNIASYALLTHMIARVTGTDAHELIIQLGDAHVYRDHVDALKTQLEREPRAFPKLRWAREDINDIEDFVYDDFIVEGYNPHPSIVMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP43</accession>
    <name>A0AA38NP43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_362428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793445">
        <property type="protein sequence ID" value="KAJ3782945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP43"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="80" mass="9322" checksum="7C61756AE5E50350" modified="2024-01-24" version="1">MLTGGWSRECEHFTFFLTFFLTFHYPLSPPSKTPNGATDKPRFQKVRELAAYLCTFCGWFLSSFLSSFVCLFVSCKRTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPD5</accession>
    <name>A0AA38NPD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_315216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793381">
        <property type="protein sequence ID" value="KAJ3784325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPD5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="509" mass="55294" checksum="CF0224A9B1D3C089" modified="2024-01-24" version="1">MECQVCQLQQRTFVCDKCVKNSLRDYRQRINRFGLERDTAVAKATTALSGAGNSGTNGMESARTFRATVSSLERRVSELMDGLAALRKENEQKRDRLQTFRTKLAERRQTLTAAKTMSASPSVTVSSVVISAHASLASLSSSIAHARTGLVQELVEVFGISHDDTHWTIANLILPVPGDMRRYPPDHLNAVLTPTIHFLNLLAFYLGVKLPFHITWTQGKLGVGLPYIGAVKGVGSESGGWARWYQQHPLHVSASSLATPAPSSPFTSITLPQTEPTSSASSDAGSPSASTSLANVESMIFDPHLGIDPSIMQNRLITSSFTTGIAMLLYNVSYLAYTQHGVNVPLHQVAAGDVLSTLWGICFGISTDYIRYSHETASSLTPNPCSFPLHRLPPPTPPAFALEFGQLLQAMSRPTPKSTVQAQGMNYISTPNSISPSYFSKSSTARPVLGSSSATRPQKQEKAKRRASEVSLTKNIMKNVKSVEMSPFREDDHEGGEGGRQDDDGWDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPF8</accession>
    <name>A0AA38NPF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_293869</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU793368">
        <property type="protein sequence ID" value="KAJ3784670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPF8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="528" mass="58619" checksum="140BFF00DE593CE4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQS9</accession>
    <name>A0AA38NQS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hsp70 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_343585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQS9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041351372" evidence="6">
        <location>
            <begin position="24"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="562"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="894" mass="98475" checksum="8D914C4DF6BE64B8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR26</accession>
    <name>A0AA38NR26_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR26"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041223046" evidence="1">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="20012" checksum="9BA6C07EE9E89B67" modified="2024-01-24" version="1">MLVFPVMRFASAYLGLIGLLSVARAMPMNQQPSLVSRASHTYIYTDVKFLKEPPPSMANPPSTGADQTLSVVDSVSKDAKDILKSFLSRHADDDHVYQVALKNDYPFNQLGDIIYYSANRRFLIDHKFPDVSEVYGWVLSRKDDQGKFHGFERSQLLPLPSPSETCMTCFGPHTGPPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NR72</accession>
    <name>A0AA38NR72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_342926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NR72"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23542" checksum="9CAC7331D75A37EF" modified="2024-01-24" version="1">MIQLLDMNSATSIQFCVDECESESSQRVQVHVIGTRNFVSTKLHGKRPSNLFVGMRVFGDTPKDKIYLSTSPVKCKSADEPEWHDNLGPAWLSPRSSISFSVKTRSKFSKTTTVLASTESYTLKRLRKMQGSMDRISTIALPLRSQSSQKDFPVDGVLIINLRELSTSNSGMEEYTSLKSAGSQRSSLEDEQELNLKNPLSPVSIESRFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRB3</accession>
    <name>A0AA38NRB3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_425532</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="451"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="1014"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="688"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="766"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3789656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1104" mass="122161" checksum="B63BD861ACB47D19" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRK1</accession>
    <name>A0AA38NRK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_401261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRK1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="459"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="188"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="658" mass="73220" checksum="51E85067162CBB33" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRK6</accession>
    <name>A0AA38NRK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="10">FBP aldolase</shortName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_342443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3789815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="358" mass="38918" checksum="54AE9E1CF08FE7A4" modified="2024-01-24" version="1">MGILDIVPAGVLTGENVVKLFNYAKEHKFAIPAVNVTSSSTANACLEAARDIKSPIILQVSQGGSAYFAGKGLANDKQQASIAGAKAAALHIRTIAPMYGVPVVLHSDHCAEKLLPWFDGMLEADEVYFKEHGEPLFSSHMLDLSEEPKEQNIATCVKYFKRMAPMGIWLEMEIGITGGEEDGVDNTGVDNARLYTQPEDIWDVHSALSAIGPNFSIAAAFGNVHGVYKPGNVKLQPGLLAKHQEYASQQLGGKVEKPLFLVFHGGSGSTKEEIRTAVVSGVVKMNVDTDTQWAYLIGIRDFVTKNSGYLQSQVGNPEGPDKPNKKYYDPRVWVREGEKTLYARVKEACEDLGNVGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRU7</accession>
    <name>A0AA38NRU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_341864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRU7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="175" mass="19142" checksum="92E723F9894AD44D" modified="2024-01-24" version="1">MFSLVTSFLGRTTLYPRHIVISPLPSVFAIQSIDLQGPRGQQYSEDVSHFWSSTYSMLAHAQHVSPTAPGHLIIGGLPFVVFGVGLSVGLGNVYTFSYSPSHFARLLQVSSYPRSTSILCSSCSHGKRSFFFSEPHIGFSCCNFSIGHGHSKLHQKLPSDAARSRTIYTAICITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSE4</accession>
    <name>A0AA38NSE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_341409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSE4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="624" mass="69759" checksum="4D29F7FFCEA3C965" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTN5</accession>
    <name>A0AA38NTN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_302186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="351" mass="40287" checksum="FE5DB8ECAC7E1673" modified="2024-01-24" version="1">MPIRPSNSIQAKAKSKEGQNNLQAKRKQGDYWNDETSSDPAEDEANADNADAPRVAQWVDEDALEDGFDKAESSQLTGNNLTSLEAGLSSLPMGTLRRAQKILKVKDISDASDSESESSEDDTRPKPEWSTKPRTDISKRKNKHAPIEITSKRPVTRRRTVVNVQSLQVRDPRFLPITGEFSSQKFNDNYQFLNESHKAELSTLRENLKRARKMLASSPRDTKHEREVEVGRLELALKKAESTVNKDRRDTIEQEALRAARREERTKQEAGKGKWYMKESEKKELLVRARYDAIAEQGGHRAVKKSIEKKRKKIAQKEKKSRPLANGTYLESRSFEHNSHDRHRQKRRKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTS3</accession>
    <name>A0AA38NTS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_338440</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1205"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1229"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1269"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1321"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1351"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1392"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="275"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="522"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="42"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3791011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1448" mass="160662" checksum="26FAAD92F88503D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTZ6</accession>
    <name>A0AA38NTZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_338735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTZ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="510" mass="54954" checksum="2340563962BDE286" modified="2024-01-24" version="1">MILLDPEDQQHGKLNSYVAGPTVRLPDRVAGRSSLLPDYETSQAQHSNPAPSPTSSTVSFRKYSLHNSVDSRFWRAALYALAIYIALSVTIGVPLIVTKLTHKHKNGPPPWAQGSNDASLSSPLVMVNSGLFSMSQSIRCNMWNSTQYGQDGLYYSSSSFSLDPSGSFSIRSSAWNTDADSTATQISGDLTVDINPDPSVTSAVFYLTTASTSLTIRDQCNICFSANGSDGDSRGLSLYIPNNLTAYQSLSFNITLLFPQSSSPLQLDNLVTYLPMFTQFIGSISPQVILDKLNLEGMQQGINTDAVWANQISVKNLVGPISGSYNATNVLKLDTVKGSISAHLIVVQGPTRKEPTFFSLDTGESEITADVVLLAPTPATANHNVNFIGHVKNFDGPIVLNVTHDESTLPVPLDLRVQNNQAPCNISLDSKFSGNYDVSTKLATASVSLTPDLHDYSGDGPRQMFPEVDTMSVKHGWVGWGSQPAQFNPRQQGQVVLVSSLSPVTLIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU56</accession>
    <name>A0AA38NU56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phytochrome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_527</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="737"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="1111"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1470"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="70"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="674"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1382"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1421"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3791192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1647" mass="179047" checksum="130BBFA6DB2CA087" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU77</accession>
    <name>A0AA38NU77_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial 54S ribosomal protein YmL47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_397997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU77"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3791195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="201" mass="22093" checksum="DB72FD1B73F50F05" modified="2024-01-24" version="1">MFFLSSPISLFKPPLHIFTRNRGQLAPRQVKYIKRHKGVIPIPIGGSIKGTTLAFGQWGLRIKGNGVRFSAKQLTTAEEVIKRKLKVLKGTKVYLRVFPDIPVCIKGNETRMGKGKGTFEFWATRQPVGRVIFEIGGPTPIREELARDILRQAASKLPTKMEFIGRDTPPRLGNLVLHPPKPPAVGVGDSPVSVGEPAVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TYI4</accession>
    <name>A0AA38TYI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_42974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793259">
        <property type="protein sequence ID" value="KAJ3789524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TYI4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="369" mass="40831" checksum="F4C0B670E9EF9BBD" modified="2024-01-24" version="1">MTQNSAEEQQHAIVLLYNGGHVIAVIPQTFAYGIYAVFFSVSSYVMFRRGLATLARKALFGISIFMFSMSTIHWTASIVTLIRIIQVWFLALDPDAQKPPNFLPLFNALILVNFFLSDGVVVWRAWVLCSVDGTKILMMCLFMLGLVFISVIATIAFRITLMVSGVVHPGSDPLVVQFTQAINVTQVATLVLSLSTNLLATFLISLKAWKSRIEIRNILDSSTDRQSRAGKIFALLIETGVMYSVSCLMVLVSSLIPLRGLDGTVGDLYTPLSAQLAGIYPIVVLLLISHSYTLDRTVRAFSSGLEQFNENQIPNIHNGPLETMRFRGNHHRESAIAAGHFFGNRSDDSSRSELNGQQKHENANEDGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZB7</accession>
    <name>A0AA38TZB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_344186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793264">
        <property type="protein sequence ID" value="KAJ3789163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="65" mass="7599" checksum="7DA279861695FDCB" modified="2024-01-24" version="1">MLANNFAVQSLFLDYILLFRCGLSLLSIFCRLGLFHLRVTNLSLLQLFCRIFFFFFGLTWGSRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZH3</accession>
    <name>A0AA38TZH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_341656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="192" mass="21206" checksum="272B944BA1BBC56D" modified="2024-01-24" version="1">MHLPIPCSSPVEISSFLGFSPKFTNSSPTCSLYLLTFIGLALLAVAVSFKHFLAQKSRTKQGQLANHQLEKERTQTFQRRTWITFINGWDGIHWPVTLTVPPTSTSVGRGVGLNGAVLGKQMSQPIRNNSSFDQRLPTIYQSKEPISMAKMIMSRHTFRRPSSPVQTTSQATTRHSAALPLSPAPSKPQSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U039</accession>
    <name>A0AA38U039_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_383349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="322"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="1174"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1386" mass="153288" checksum="B80307FE36EE2F99" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U043</accession>
    <name>A0AA38U043_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADPH oxidase regulator NoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_383974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U043"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="461"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3789613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="547" mass="58872" checksum="0625CB6C967198DA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1F1</accession>
    <name>A0AA38U1F1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1F1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="409" mass="44783" checksum="89DC3AF5A682F7A8" modified="2024-01-24" version="1">MVVMDFDTAWCPVCDRQIAPKRTTQLVTTDQRLATGTNGPARQRNAQNRSVTKTKTVIDQGPYPLYCSDECKMADMLHQHEDVYAPPTYPIYHSSTRSHSLSKSENTEGSPPSDIDSDCLSSTTTDLSYPSPTFESAVLPTATQSIACQPKQRSRSFLTGNPSRSGPRHIPSSLPTTSTISNAFGDHEGKSTPPTQDDFLLSQFQGSFTRRSESRVSMYSSPSSPSSRSPPSISALSTSPPRRERPLLPHSAQGKLLVPDVYVRVPTKPSTSRRESSSSLASLASISSAPGAFTSRNRTGSMASIGSSRASLKSPLARYGNELDDEKDLSEEDEYACDDDVPSSPALGGFGFIKRPLMSDMRSWSFDAYPQSSSGSAFSTIRERRKSDKKEDRQRYNPDGKKLFLFPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1W4</accession>
    <name>A0AA38U1W4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_391552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1W4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3791279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="970" mass="108536" checksum="B1907424106B415E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U685</accession>
    <name>A0AA38U685_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_400225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U685"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="493" mass="53405" checksum="F492FDC0F3CAA4DA" modified="2024-01-24" version="1">MASHSSCPASNDHDETTPLLTVSNTEAQQLVKRATPLPKAQIAALCLVRLADPIAFTQIFPYINEFIAFLHVTDDPSQIGYFSGLVESTFAVTQLFFIYYWARLSDRLGRRPVIMTGTLGVALSTMYFGVSSSILDLLICRCIAGVFAGTASVVHTVLGEITDSTNQAAAFPLYGLVWPIGSIIGPLIGGSFSSPASQFKTFKETIFERHPYFLPCFVAGLLSIAGFTMAYFCLEETLATKQRPGEEKNYSTPEHNTHEPAPVTPSARELLSFPIIRALSLSGFALEANGTSFAVLYVLFCYSPIQNGGLAFPPSTIGYSLAFAGVIAGSAQVFLMPFLLRRFEAAKIYNMSITAWPVTFLILPTLNMIARYGLDESTGQLGSRSHSALWIGIVIVLALSRVGGIAYSASMILIRNNVPKPSYLGSANGLVQAFMCFSRCISAVFASSVFAFSDKYNIFGGYFWALLYASIALVGCSLARDITRNSKNMLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7L8</accession>
    <name>A0AA38U7L8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_424888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7L8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041358320" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="372"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="480" mass="49669" checksum="23911FDA2390EE27" modified="2024-01-24" version="1">MRCKGLDVILFTVASCTTCIAAITVPTTAPSTASTIDSSQVAVSLEFFAFPGYTELVSTETCLANLQALRGAPVAVRIGGTTQDRATYDPSLATPVSYTVASPTDAPTSLTFGPSFFTLAASDLKGNVTIGLNRQLNNQANTLSAAVQAKNSMPNMYAIELGNEPDLYASTSPIVPSSGWSQTADAASEKSWFTAIAPSVGNIFQAAVYLSWRTTATIPLLGTSINNVRSVSEHSYPQSACNGATTDLSTLMSHSGIVSYTSGFKADAASAHAAGVRYFLGETNSATCGGGGISPTFGAALWIVDYVLQGALSGIERSYFHQGTIGDCQYCWWGRFTTGAPFYGAYFVSTFLGTDGAKLEMLDNGTGAVASYVIFNSAGAPIRLLVYNSNYYDGTGTRSSTAVSFTGGGIPSDGTATALRLTGPNATSRVDEGGIVTIGGGVTFDGNCNVVGTETRENVVVTGGALTVSVQASEALIVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7S1</accession>
    <name>A0AA38U7S1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">GGU10DRAFT_329086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7S1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3790695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="284" mass="30724" checksum="955EF90118BA1E20" modified="2024-01-24" version="1">MSIPKTSWADDVDELVSGQQEDDSIRTVVEYSVNEQGKKVKITRKIKRTLQKSIVEHQVAERQKWEKFGAEKGNARGPDRATTTVGENVYLTLSAGNKSAESEQQEEKKPIKSTTGGKVVCRLCKGDHFTAKCPYKDTLGPLETSGDTGAGPDDDTIPPPDAAPGAGPTGSKYVPPSLRAGARGAGETMRGPGGGTRDDLPTLRVTNISEDTQENDLRDLFGHFGRVARVYVGRDRDTGAGKGFAFVSFEDRAVAQKAMEKVNGKGYDNLILSVQWSQPRADPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7Q8</accession>
    <name>A0AA38K7Q8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arginine biosynthesis protein ArgJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_279051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793687">
        <property type="protein sequence ID" value="KAJ3780624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7Q8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="180" mass="19759" checksum="BEA3311A9B63A4E1" modified="2024-01-24" version="1" fragment="single">LQPVLTYAVKPSFNSISVDGDMSTNDTILLLANGAAAEKNGVMLEEIDKETDKEAFEVFKKELTDFTVDLAKLVIRDGQGATKFVTATVKGAPIYEDVHHVTSRISTSALAKTALYREDANWRRVPATTCSVPLSSPLHPNKVSVTYGTTSLPVLVQQLYVLAHSFTPQRIANDHFAQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8F7</accession>
    <name>A0AA38K8F7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_429757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793515">
        <property type="protein sequence ID" value="KAJ3781899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8F7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="661"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="779" mass="86499" checksum="9BED8B4A2A7D2220" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8Q9</accession>
    <name>A0AA38K8Q9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_436549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793467">
        <property type="protein sequence ID" value="KAJ3782574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8Q9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43868" checksum="535418725301F02E" modified="2024-01-24" version="1">MLPEEILHLVVEHLVYNPASAESQLFQLHWKHSRTRLLSLSLVSHQLRRICMPFLFAYVEVRGAYGDLEKLRNQCLESKFFALSISLSKVILDSIRLRTQAPEHDLAKYLRSGMQISSFSACNFSGLCELELWLDASPDLSWLPSFIDAHPFLERIRFSTVLVQWNAHRDVPFILPFIDAVVEEGLNDTLQIKGFSIARTSSSTASSLPAADIYTGWNVAGFWFCFTKWSSGRLLHLTHSFFPQISVLSIEVPMPNLNRTYMDSDEFINSLCRFSSLQTVNFVYLFRGLKFGSSEPCHSLKASQTYQGHLGIRASSHNAARQTVNELEAALICYTSCIAQRMPTVQKFLIQEPPLQGWIHVDRGGTSGTLRPLMQFEMNQLFSSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K953</accession>
    <name>A0AA38K953_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_428933</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="MU793412">
        <property type="protein sequence ID" value="KAJ3783594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K953"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="15">
        <location>
            <begin position="386"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3783594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="688" mass="74747" checksum="3BC68CD4DC54D2EB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K976</accession>
    <name>A0AA38K976_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_243645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793406">
        <property type="protein sequence ID" value="KAJ3783729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K976"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041358450" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="87" mass="9705" checksum="04F6AF88CC421EE0" modified="2024-01-24" version="1" fragment="single">MDNLFAIGFGLCLRLVITLISQDSPSSLKVTGTLVGLWEGIVLLHFTQKWPRSYDPYVAYGVRMFVDLMVTESVPRMVLVAIWTGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9I0</accession>
    <name>A0AA38K9I0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter Ostalpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_33270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793383">
        <property type="protein sequence ID" value="KAJ3784269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9I0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="434" mass="49938" checksum="F74196335B030FAC" modified="2024-01-24" version="1">MPTCPSDNQQTVDQTDFWTDGGIDWDAHRIGWAIAGACAAATVIISSISVLQHCRSYTNPAEQRQILRILYMPPIYGVISFLSYRFFRSYTYYELVEVVYEAFTLSAFLMLLIEFVASSGSGHKAESSIARKDKRKLPFPFCHWRYRPTKPYFMYTLKWAVLQYVIFRPAISIAAIICQAYNVLCESEGFDAQYANVYLEAVDFVSISVALYGLFLFYGLTKEELVGRRPLAKFLAIKLIVMFTWYQSFVFDALEGRVIHATQYWTETNIADGLNALAICIEMIFFACFMWWAYTPAAYRIEGAKPTSIWRPLWDSINFSDFALEIWSSFRFFISYIRGIPETRSRYAHQVTGFDEAFGLEKSGRAAYVEHNSSESVIRGQNGRTSEYDSSRAPRMSYDEDIRLAPYRYGDARDDHDASTPVDRYVSEGSHPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9I4</accession>
    <name>A0AA38K9I4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_402120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793383">
        <property type="protein sequence ID" value="KAJ3784284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9I4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041204092" evidence="4">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="YDG" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="162" mass="18918" checksum="707488A67E46D08F" modified="2024-01-24" version="1">MPRNFSSIWLCLCYLLVRLIEHVLSVKLIHSTRNGEYENDIDNGLTISYTGAGGRINLFGKQKEVCMNQDWKSAPNRALLHAYRDRKPIRVIRGFKLNGAYAPKQGYRYDGLYRIYKVYTKVTNDSKKHRLCMYELQRLSDQDPPPWETTTADRLELKETGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9W7</accession>
    <name>A0AA38K9W7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase/mRNA capping enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_270178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9W7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07896">
        <property type="entry name" value="Adenylation_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08041">
        <property type="entry name" value="OBF_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029319">
        <property type="entry name" value="DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006592">
        <property type="entry name" value="PRK09125.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14743">
        <property type="entry name" value="DNA_ligase_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="8">
        <location>
            <begin position="186"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41504" checksum="87530FA78DCC3DFA" modified="2024-01-24" version="1">MKDGEEKEVQSQTSSSTYKVKRTMDHYYCTCPAWRNQPSVPVNARSCKHLIALLGEKYEAARIKLKNPNGAALRSPNKKSSGSKKGKDSSKIDVAVLLANSWDVDKGPDPTGWWISEKLDGVRTLYDGNRLYSRLGNSFTPPQWFLDKLPKDVTLDGELFGGRGDFQNTVSIVKTMNSPHWKGITFHVFDIPSLSTQPFEARMERLKKLFAPGVGSHASDKVLVVEQEKAKSRQHVLDKLKEVESLGGEGLMLRKPESLYEGKRSSTLLKIKSFYDAEAVVTGYKAGKGRNAGVTGALKCKMASGKTFDVGSGLNDKQRKSPPKIGSIIVYRFQELTKDGVPRFPTFLGEAADKNKPKDAVVPDHRKAVVKKDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KA15</accession>
    <name>A0AA38KA15_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_292638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793349">
        <property type="protein sequence ID" value="KAJ3785214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KA15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="73"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="315" mass="36008" checksum="F2AB12FED6F33032" modified="2024-01-24" version="1">MVQRADLWTTILAVALASLCYLLASKFRLVLNMRVKGVDLQEDKSLARSSGSQDSEEKLGLRNSVESRQIYDVFLVLDVEGTCELGSGFDYPNEIIEFPVCLMKWKNDKERRELEVVDEFHSFVKPSWRPTLTNFCMGLTGINQAQVDNSPSFPQVLESVSQFLVKHGVLDADYHEPLLRFCWCSDGPYDVRDFVAKQCFISKIAIPAWLRGDVLDVKKMVISWFIRQNYRGRKMKTMLGRIPLRPSLNISSQLRVLGLPAFQGRKHSGIDDARNIARIVSECAHRNICLQPNTHIDPNRRWSWMGKSGQILLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAG1</accession>
    <name>A0AA38KAG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_375159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAG1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21810" checksum="F1406D7700FC1224" modified="2024-01-24" version="1">MATTEVLSKARHILLKRIPALTTPADIRRMLTRYNVQGVADVAIIYENFMPTKQAIITLALPNFLRDNLRELTNATLSGVVFTSEEVDYSESGPPPTELGTGPHAGVDNIGNNVVLSSFPSGTSPTNIKTITDKYLLASSFEESVFSIKTAPKNPVSMLIKLRSESEAYRMVRDLHMTNPLERLRWSRDLQARVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB55</accession>
    <name>A0AA38KB55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_280435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794417">
        <property type="protein sequence ID" value="KAJ3779668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="72" mass="7719" checksum="3BD6D17D7D7FD5A0" modified="2024-01-24" version="1">MSQDSLDSSLSPDTWLIDSACTKHIIRNKSLFSTYSETPGHTVKGFGQSPAIGQGSANIATHLGKHTFNLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC79</accession>
    <name>A0AA38KC79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_82798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="611" mass="66399" checksum="FC8CAD88ED257880" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCK2</accession>
    <name>A0AA38KCK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_276592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793512">
        <property type="protein sequence ID" value="KAJ3781933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCK2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="92" mass="10373" checksum="3A7E24C6FEECC96D" modified="2024-01-24" version="1" fragment="single">ARISELQAEVERLQAELGQDEDAEKIVHNHIKLLHQYNEAKDAAQVHSHRTGQPLGSLSIDVLTFNTCLQLANLRETTVRQIHKDLELPIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDG4</accession>
    <name>A0AA38KDG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_437714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793662">
        <property type="protein sequence ID" value="KAJ3780746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDG4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="222"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="803" mass="90635" checksum="E30D0C72CAB134FB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDY3</accession>
    <name>A0AA38KDY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ndufs2, NADH:ubiquinone oxidoreductase 49 kd subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_365784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793529">
        <property type="protein sequence ID" value="KAJ3781736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="198"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="468" mass="52610" checksum="DD12B419F5FC8902" modified="2024-01-24" version="1">MASMLLRSIARSTAAKFPTSSNLCRSLTTSPISRLAEPVPAADSAQTQGGKNVFEYHTVEDLQGMHASEILAETGTRADAKMRHFTVNFGPQHPAAHGVLRLILELNGEEILRADPHIGLLHRGTEKLIEYKTYIQALPYFDRLDYVSMMTNELCYSRAVEKLLNIEVPDRAKWIRTLFGEITRVLNHLMAILTHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHSAYVRPGGVAFDLPHGLLDDIFQWATQFGSRIDEIEEVVTGNRIWKERTVGVGVVTKEEALNYSFSGVMLRGSGVPWDLRRTQPYDMYDQVEFDIPIGVNGDCYDRYLCRVQEMRESLRIISQCLNKITPGAIKVDDHKLVPPPRASMKESMESLIHHFKIFSEGYSVPPGETYSAIEAPKGEMGVYLVSDGTNRPYRCSIRAPGFAHLAGADFIMRHHMLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFZ9</accession>
    <name>A0AA38KFZ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_270206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3784991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFZ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="110"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="343" mass="37828" checksum="CBD5762D489C4CA0" modified="2024-01-24" version="1">MSSFFPSLYTVAKGAFATTVGLGTLSAGLLYYGQSYLIYPSAFTKIGEDDGAPSKPASYGLHHELVDLKTKDGETLKCYLLLQKKDLPQVCATESGYSEMADEQLVSQRPTVIMFHGNGGNAGHRIPLGMMFQQVMRCNVLGVEYRGYGDSTGTPSETGFAIDAVTALEFVRGDARLRNTPVILYGQSIGGAVSIDLTSRFPGEISGIILENTFLSLRLLVPHVLPFLGPFSWLCHQRWESAGKIIGMPEPVPPQHMKYLRKIFVTRPHTRRTLGLPPLPISQEGKNGVNEVNEERTQFIAFPEGSHNDTTAQHGYWNRIGDFVAEVGKEWREQQSLGNRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGP7</accession>
    <name>A0AA38KGP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_394747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="367" mass="40677" checksum="DE67701D1288F597" modified="2024-01-24" version="1">MSSANLVTSNLFSPLRVGNMQLHHRVVMAPVTRLRTTNDTSSLLPIVKEYYSQRASTPGTFIISEGTLIGPRATGFPGAPGVWSDEQISAWKEVVEAVHAKGSYIYLQIAAMGRLAQLSVLKSYDFTYDVVSAGDIPVEGGEVPRPMSIEEIQASTEPFAQAAANAVHKAGFDGVELHGANGTLIDQFIQDISNNRTDEYGGSIKNRVRYPLEVVDAVARAVGEERTAIRFSPWSRDSDMGMKDPIPTYTYLISQLKEKHPNLAYLHLIQSRNLDNPKETNEDFFDVWLPRPLIVADGFTRETALKVAERDGVLVGFGRHFISNPDLPLRLNADIPLTHYDRTTFYGGEEKGYIDYAFASGRNDHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI10</accession>
    <name>A0AA38KI10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_285961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI10"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="215" mass="22658" checksum="9568074565851B70" modified="2024-01-24" version="1">MSMLLACVSRSASFAPIAGRRAASAIALKYSNAVYNAALAKSPQTLTKVHTELAGFTATLKQNKDVDAFVHNPTLSAKDRDAGLVSVFKALEGAGSKKEPVSDITKNLLTVLSENGRLAEIEGVVEGFNELVSQYNGELNVTVTSAAPLPKDVLSRLESTLKQSQTAQKAKTLKVTNKVNPSVLGGVVVDFGDKTIDLSAQSRVTKLNAALTQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLL1</accession>
    <name>A0AA38KLL1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_300320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793618">
        <property type="protein sequence ID" value="KAJ3780990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLL1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="364" mass="40637" checksum="566A74DBB27014DC" modified="2024-01-24" version="1">MSALLSESYTFDPRPYYPLVSTLKRFRDPSWTENGLTLVFAHGTGFHKEQWEPAIDELLGFIAQQTPNKIKIREIWTIDAPNHGDAALLNEQALQYGYELVFQWQEYARSIHAFLTGRGKTLLGNLDLSSEGKVMIGNFDFTSHTIVGIGHSMGAISLLLSLDFAPSLENLFASIVLVEPMTMEPAAAAKGPANKLASGSESRRDTWSSVEEAYRMLKARRTWQVWDDRVLRIFVASGLRPLPTLEYPDIKDGVTLKCTRKQETAAYRDTHGWVTIYRGFKSYASRVRIHLYYGKMHDYIPSEVKEDVINNASGGAQNLASFGYIDGAGHTAPQHSPLGVAEKIFLALKADAKARAESEFTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM74</accession>
    <name>A0AA38KM74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_429362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793457">
        <property type="protein sequence ID" value="KAJ3782744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KM74"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="42"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="439" mass="47920" checksum="144BB89A5EA12BF9" modified="2024-01-24" version="1">MEPGRKIQTADIPATPSPNPQDIDEKNYEVIDVTFPEGGLQAWLTVMGGWMIVFCTFGAIQSFGVYQDYYTRISLSDQSPSHISWIGSVQIFFLFSGGIISGKLFDDGWFRGLLLSGSLIYLVSSFLLSLAQPHHYYQNFLAQGVGMGIGMGIIFLPTLSVTAHYFKRKRGLVMGIILSGSSVGAVVYPIMINHLFNGSSGFAWGVRAVSFLDLGLLVFANLIMKTRLPPRNKDPNAKPVNTRAILTDTPFWIALFGILLAFWGLFVPFFYIQTFAVTHNLPGFLQTYALSILNAAGFFGRTLPMFISDIYGPLNVIIPITLISGCLVFAFLGATNVGGMLAFAILYGFFSGGFVSLSAPTAASFSQDIGEVGTRLGLMTFVSSFGLLTGNPISGAILHPPEYIWIRPVVFSAVTVLGGVLFLLIARQIQAKRRKTHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KM79</accession>
    <name>A0AA38KM79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_274898</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793454">
        <property type="protein sequence ID" value="KAJ3782774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="913"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="260"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="588"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="922"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1206"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3782774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1466" mass="164032" checksum="1164C50F81EAC6FB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMG7</accession>
    <name>A0AA38KMG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoaB/Mog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_361915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793438">
        <property type="protein sequence ID" value="KAJ3783059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="161"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="529" mass="57595" checksum="06DEBA6D137055BD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNE9</accession>
    <name>A0AA38KNE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_436042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="429" mass="47814" checksum="F711F33258FE19A1" modified="2024-01-24" version="1">MSTKKEHSSNRRNLPIGSRNFLGYHSRSEERVRRSKKLKLSSDDLERNTNLVALTRELKRCLRNLAAYKPPKDTFPQPWLPFPKSRRAAVLVALFVGRKGDLYVLLSKRASTLRSFAGDTSLPGGKMDPEDKSIEDTARREAFEEIGLPPDRNKVPLLCILEPFYVEKQLLVTPVVVLVLDNTLQPILNAPEVTALFSHPLASFLSSTPPASIIRSEPELVELGDDGSGYRYHTSNDWDWDGPPLVLDPPENKLSKNGSANRNGKKRRSFSDSSLRTFKRSDENEVKVSNEPVFRKRKFRMHQFLTGREAGGIKPVFGLTAAILIHTARAGYSPSPPALASPDFEVSAPDGASTSMRIAWAFYRPPTSHRPNLLREALENEGLAGKVNWERVRKVAGVPDENAVSQKGASSAISGSRRLGQTNWIRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNN3</accession>
    <name>A0AA38KNN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_437588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793620">
        <property type="protein sequence ID" value="KAJ3780966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041453397" evidence="1">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="231" mass="25556" checksum="D4DD3976656E61F4" modified="2024-01-24" version="1">MYLRANTFFPTLFVSLLFIASTFAIPISPDSNSSPTLVDRDVVPLHARVNAPSASPPPYGSTAIATKPLEANVLFQGEQLSEEDFTALRSAIETMLKPVVWLFKSEIQASIPRDLSKYLSEINDIPVTTIDYGLRSRITAWTSDTEYEFDFTIASNVKQNLFSINGHPFHGTIARASLSNGGKLTGRIWALNQQTMKKDEIVSFTDGKAKPRSRLSHALTRYGLRRGGTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP79</accession>
    <name>A0AA38KP79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin synthase</fullName>
            <ecNumber evidence="8">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_411427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="8"/>
    <dbReference type="EMBL" id="MU793545">
        <property type="protein sequence ID" value="KAJ3781566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF44">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3781566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="419" mass="46453" checksum="AE8AA797E1A58DFF" modified="2024-01-24" version="1">MSQTVPDVPSIPYGVNNGYGNYPPARPGPHYAQSTGAYSVARDKVLQGRAVKQVELFQGNLVLDVPVSSHIIPAGRQDVEEMSEMHYTAATCDPDDFLKSRYSLRPYLLGRQTELFIVMTMYNKDEVLFTKTMNAVLKNIAHLCGRSKSKTWGSEGWKKVVVCVVSDGHSKINKRALQVLSLMGCYQDGIAKDSVAGKDVTAHIFEYTSSVMVTELVCVLLDVGTKPTGTSIHELWKCFDKHSNVGGACGEICVDTGRGCSLLLTRPLAASQNFEYKMSNILDKPLENGPDGKGPLPASYFKGETMHGGGPNGAGLFERNMHLVEDCILRFEIVTTKQEEWVYVLFQTYTSSLNFSLTGLHRLKYAKSAKASTNVPASVPEFISPRRRWLNGSLFASIHSTVFWFKIWTSGQNFFRKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPP2</accession>
    <name>A0AA38KPP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_428425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPP2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041370042" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="460"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3784620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="637" mass="68487" checksum="4E8442CC211B0823" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPT8</accession>
    <name>A0AA38KPT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Spb1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_429561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793487">
        <property type="protein sequence ID" value="KAJ3782271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="245"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="664"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="620"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="849"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3782271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="888" mass="100388" checksum="CBEB214DC936A782" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPZ8</accession>
    <name>A0AA38KPZ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_394886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>melleolide F + FADH2 + chloride + O2 = 6'-chloromelleolide F + FAD + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:167712"/>
            <dbReference type="ChEBI" id="CHEBI:167713"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67161"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793327">
        <property type="protein sequence ID" value="KAJ3785939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPZ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140907">
        <property type="term" value="F:flavin-dependent halogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="638" mass="70637" checksum="48C1EED63EBE0168" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQH2</accession>
    <name>A0AA38KQH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_273983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793430">
        <property type="protein sequence ID" value="KAJ3783231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="382"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="639" mass="72040" checksum="273228EF044C3610" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRL2</accession>
    <name>A0AA38KRL2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_426541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793283">
        <property type="protein sequence ID" value="KAJ3787904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRL2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="333" mass="37121" checksum="ED96043DAD59B4B0" modified="2024-01-24" version="1">MPLPLRKIGNAQVHPIGFGAMGISAFYGKVEPDEERLKVLDAVYDSGYRHIDTAHIYADSEALLGKWFKKTGKRDEIFLATKFGITLQGPRGDPEFVKEQFATSLERLGVKSIDLYYQHRPDPKVPIEITVGAMAELVKEGKVKYLGLSECTAEDLRRAHAVHPISALQVEFSPFVLDIESQETKLLETARELGVTIVAYSPLARGLLTGQYKSPDDFEEGDFRRTVPKYQAENFPKILDVVKQIDNIGRKHNATAGQVTLAWILAQGDDFVVIPGTKKIKYVEENMGAADVKLSPDEINAIRKIAEESDIPGTRYAERQMQTVLVKTPPLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSB9</accession>
    <name>A0AA38KSB9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_89240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSB9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="195"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="547"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="671" mass="79487" checksum="7BE73A531338CCA4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTS0</accession>
    <name>A0AA38KTS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial translation optimization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_308966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTS0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="588"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="678" mass="74997" checksum="863E6BB6E9A33D44" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTU1</accession>
    <name>A0AA38KTU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_415724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="509" mass="58514" checksum="466821F6F280F091" modified="2024-01-24" version="1" fragment="single">RPLTFDRANRGRPIKSSFPLFRLPIEVLQDVAPHIPSLDLETLAFVDRDCRQLARSVQFSNVRLTFNDASLGLLETLLAEVQARDDLLQALGPCIRHLTIDLGSPMLTEARLKRYPNLFNFHQRSPELKSVQDTFLGALAIVLSYSLPNLQSLNWQSRVMISTELMQGIIMSKARDVAINYAFFDLNLDVFDFYDSPRWLIEKFVLDAEWMIQSLEDLNPINVTTDILRAVSPTLQSLSWKGTRLPLKLSFGRETVIFPRLRVLRLDAVPMADDSILSSFLSSNSRIITLEVSSTDRNTAEFLGRRGHLETLESFSWLNQHDSFKEEIICFLEANCQLRSLSIAQSLSPTTIDTRILPVVKSSFLHLTSLHLVWDAVTIPESSLSVIGSLHRLRRLWISAGAQLGWCNNWKIEHDVILHTLRPLRQLEFLTFSRDSYEVNGHPLLDSSIEKYYFNAVFPCDQARSLQTRLMKAAWERWHQHRMLKFAELYANTFVQLIWCNIGQYPIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTV6</accession>
    <name>A0AA38KTV6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_379895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793605">
        <property type="protein sequence ID" value="KAJ3781092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTV6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="98" mass="10948" checksum="9BB2E6475A909698" modified="2024-01-24" version="1">MSEELAQDEADAEDYDLEYLERGRGARDDDEATLRGDEHGHPVGEDSVVFEIGDEEEDMTPITAKSSALTRQRSGPERPSGEHAEEERRGFPSDDKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUE2</accession>
    <name>A0AA38KUE2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_306905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUE2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041333727" evidence="5">
        <location>
            <begin position="19"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="488" mass="52151" checksum="61504DE8EA809E75" modified="2024-01-24" version="1">MKALLFSVLVSNFVSVFSSPHSARGSLSDVCNQIAQAISSESDVHWPLDLLYDKDISHWASSSSAFAACSVEPGSAADVGIILQILGETSTPFAVKGGGHASNPNFSSTTGVQIAMYRFSDVVYDAASSTATFGAGLVWDDVYAALAPYNVNVVGGRVTGVGVAGFTLGGGYSWKTNQYGLTIDTVTAFELVKPDGTVANVTQESDPDLFFALKGGFNNFGIVTRFTLQTFPQTQVWGGLITFTENEISEVIDATHTFASNVTDPKAAIITTANFVLGQPGISQLLFYDGPTPPDGIFDDFLAIPFFTKDVSTRDFVSLVQSSPSNATAGTRAIFDSAPLLELTPTVLDAIINETVFWGARLSFESGTFISYDIEPFLPTIFTHGQSESAYPPSRSTRYLPLNLYYAWELEVADDAFHSAIKQSANQITAVALAEGQAGVDSAPLYPNYAIYDTPLERLYGDNVAKMQSVKAIVDPNNVMGLTGGFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUT2</accession>
    <name>A0AA38KUT2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_363175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="MU793462">
        <property type="protein sequence ID" value="KAJ3782652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3782652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="298" mass="34554" checksum="CE8AD0B887242DE0" modified="2024-01-24" version="1">MPIAVTGNAGRALDEASDAIDQVNIIKGKWNEESAFDQEKDKTQFRDYDAACDRVKNFYKEQHEKQTVEFNIKARVEFNNKKRARMGVWEAMEMLNTLVDESDPDTDLSQIEHLLQTAEAIRRDGKPEWMQVTGLVHDLGKLLFMFGSQGQWDVVGDTFVVGCKFSDKIIYPHTFEGNPDFKDAVYSTECGIYQRHCGLDNVMLSWGHDEYLYHVLKDQSTLPEEALAMIRYHSFYPWHREGAYNHLMNEKDQKYLEAVQAFNPYDLYSKSDGTCDPARLRPYYEGLIGKFFPPVLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVL8</accession>
    <name>A0AA38KVL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_314946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVL8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="11">
        <location>
            <begin position="475"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="631" mass="67577" checksum="3A291083D8DECC2C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW03</accession>
    <name>A0AA38KW03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_355811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
            <topology evidence="1 7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793353">
        <property type="protein sequence ID" value="KAJ3785082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="78" mass="8636" checksum="B7EDAB035FD13E65" modified="2024-01-24" version="1">MSLSLASRSTARARSVIFRRQLHASHGVRSPHGEYHHLPFAWPHDKKTSFALKLTAYLGFGFAIPFIAGAYQLKKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWM1</accession>
    <name>A0AA38KWM1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol-glycan biosynthesis class S protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_415471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793700">
        <property type="protein sequence ID" value="KAJ3780563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWM1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3780563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="500" mass="55624" checksum="9063D1B2ED7ADBD3" modified="2024-01-24" version="1">MDAESRFRDPSSLFFQFDTIRRYIIASYWVLITLALPLWWTTTSIERLPLPTSEVYAQAQKRLEIPLAICVDSAFSSHITSLQRSIRDAASYLDVQAHLGQDCSQFPGYAILPGERILVEDRKLYYPPSADNLASTLASLLAPKMDHRAAQYSPRFRLSFTLLNEDSSAGQVITSWDIQQAIARHIHPITSALGILHNYTIESQVQYHALLAFEPRSLSNGTVFGLTPEDLTIFINSAEWTLSSSSSNDPVFHFVLFIPSARRRPLIILNSDGTPSSSSAFLIPQWGGIVILNLPTPPPTTLHLDLPDLQSSFSSFSRHLLTLLGFPRLPPSISYSSSSNTSLSSWQIDTLIRQRIHENVIQSHDTLQSTVTLVSQIDGMPVDEQVQSQVQGSLSALHELFRYASVNLTFPEMLAYSAQALTLSSKAFFHPGMLAMLYFPAEHKYAVYTPLFASAMIPLLAAALREIAAWRKERREVRAVGDVKEATSGDGPKVDTKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWZ1</accession>
    <name>A0AA38KWZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_367465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793588">
        <property type="protein sequence ID" value="KAJ3781208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="528" mass="59273" checksum="6EDC4B9A3AD495A4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY12</accession>
    <name>A0AA38KY12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_286142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="55171" checksum="B92AC7BC01E02605" modified="2024-01-24" version="1">MSQLALFEKVISHRDDSSRGNLRPITSLANGRYDKCSFATPHSVILAPGFQSPIPHYLLPQWTAHIHPEGQLYFHRHSVLQVTTDAYLYNPEILDTVVFWIKKIEALIEEKNMPLSDSIELYILIEDTGCAYYFIDHASRSLFWLEAIPSEQLNIPDVGSSSHLSLYLEYLYWTHVEHFPMHFGGIPVKLVENLLSVFSHALTDQMTSQTSTFFYTQKECAQFIKILKLARENSSDGHQVCVIARLWRQVCDNRFVTHYGQETSRLSRDQAILYDPPQPSSRVSTLARYITFTASDAYLTKLNDLFVDRLVYFSQWQPFIRRCLYGWRRSFWSALAIIILHGFVLFVECEPLLAVVSASLTFTSLFTSLILVHRYDRLESDDACAHDVHEHLTALHSSKYNFQFIALSYALPNALQLWALVFLALNALVVLRDVVGTCCAVGCGLFVAVVLFWFLRITSERSWNLIPQALRRDKSEHDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KY22</accession>
    <name>A0AA38KY22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_346070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KY22"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="66"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="223" mass="23847" checksum="448FA2E209513081" modified="2024-01-24" version="1">MDNMNKSLDEIMKSRPRNRHSSGRNARAKVLGNTTATVTPAARQRIKATKVAPAQPAAATAQQPADKIIVSNLPQDVNEQQVKELFHTTVGPLRDVTLHYDSAGRSKGVAAVHFQRKGDGTKAFQQYNNRLIDGKRPMKIEIVVDPTRAAPGPSLAARVAPATEAIAQPNGTRNATRGGARRGRGRGGRTRKNDRPNKSAADLDAEMEDYTSSTAPAVPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYN2</accession>
    <name>A0AA38KYN2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_359693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793400">
        <property type="protein sequence ID" value="KAJ3783878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYN2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3783878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="304" mass="33573" checksum="692FFC00590045F5" modified="2024-01-24" version="1">MALEPVILNDGNKIPPIAYGTGSKMKFHDITQYIEQAIEVGFSHIDTAVFYQTEKYVGRAIKESGLARSELFVTTKYFQGVSVEKSVRKSLTNLGLQYLDLYLIHQPRVILNLVKTWNEFEKVQQDGLAKSIGVSNLVNVEQLEHLIKVSKVRPAVNQILLHPYNYHEMKPILDACAKYDIVVEAYSSLSPITTYPGGPVDSPLKAAAQRIGATPTQVIFMWVRAKGAVIITTSTTKAHMEEYLAIANLPALTEEEVASIDAAGAEGPPSDFVSRLCGNKMALAVVFVTMLLVYRCFGLGRMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYV1</accession>
    <name>A0AA38KYV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_34099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793385">
        <property type="protein sequence ID" value="KAJ3784223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYV1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="156" mass="16947" checksum="8FC69053C0FD5B5E" modified="2024-01-24" version="1">MDLDWIDREYVAPRTSTPVRHRKKPNGVSQSPEISMRIDGNTTNNGAGQRSGSGSKDTANGASPRPPGGSKSTSTMSSMQLASTPALEALLSSCEPSLLYLAPILVGLGIKTKEHMKAVGRLREETRNKEVREEALKRGMTIMEWAILLDKLQQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L083</accession>
    <name>A0AA38L083_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_385847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L083"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="386" mass="42831" checksum="3A203726E031996F" modified="2024-01-24" version="1">MIYQMGGVLFQFGTNYSSFLSLAFASHRICCRMSSSDSVQVTLGGLQVSVLIATFIYSISCFQTFLYWRSRFNDRLGILALVWAVWIFETTHTLCFWFYIFTITVKYYGVPEELERRHWSITMSIVFHGLITGCVQSYYSYRVYILSGKRIIPVVCWIGCLIEGCGSVGIAVVLYLVGPAGFAAKWELFPTLNIAVDLSVGVVNTTTLCYYLHRMRTGSKTTDQMVTTLIEWSVETGLITALAALGMLIACVVTPNTAVYLSMTSFYAKFYSNSLLASLNGRGPFSPFRVFVPPTATVVTSGTELAFTVNITQTTTSSVPTGLSRSLHRFSRGGAVNEHGSQIKSRTSAQGVQLTSIPEQYGDSVENEMTEKEPDEDARKTYTTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1Y4</accession>
    <name>A0AA38L1Y4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_132933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793646">
        <property type="protein sequence ID" value="KAJ3780832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1Y4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="199" mass="20436" checksum="87184DE9F2101BA5" modified="2024-01-24" version="1">MLRQNQPGQPGQPGQPMMNMNMNVLNGLNGPGPGPGQLGFMNSSTMNGMGPPPNSLNSINSSSSAPGGMNRFPQGGPQPSLGNQQRGGIRGGLPPQGFPGGGGPGPGGLRRVSSQPQIGPGGLGGMGNIGGMGNMGMNMGMGAIPPHLRGPQHQHQQQQQQQQQQQQQQQQRQQFAAPGPSRPLMNSLSQPPPGESCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L296</accession>
    <name>A0AA38L296_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794264">
        <property type="protein sequence ID" value="KAJ3779755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L296"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43300" checksum="C4AA11E91E79BDBB" modified="2024-01-24" version="1">MVVTKTRCGNYFKIASYHRSPSGRANLQINNSRRSGKLLLDYQPLKKYQQQFDVEVPWKECEVVVQSGRFAGYQGVVKNVRQDFRGSPHLSLWMTVFNCSIEIDHSAVVERWTKLPLLDYQPLEGNELREFKPNSLLQEMRTGPCPWLGMLVDITKGEFKGQYGAVRDVNHYEPDSRRAKGQSGIELTVERFVMTAGSTILVKVDYDAVRYHRTGLYLCDVFMPTPKQSFYIPNKAVRHGGNVLQVSQATKTAWPLPPPADLEQETIFIGPWSEVHRTPISSPAMSSNPAPTTPLVLTSPLPSPWNPASSPLHMQGLSSPYPRPPPQSEPTTSQPPSTFDGPWILHPKLVGIPIQVDINGGEMDTSNKRTGIFVETVADSKGSISVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2G4</accession>
    <name>A0AA38L2G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_232491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793964">
        <property type="protein sequence ID" value="KAJ3780040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2G4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="56" mass="6533" checksum="0BC36C7342DC8964" modified="2024-01-24" version="1" fragment="single">VVLNLDRRISVMHECHDQMGHKGVYTTLQGIHACFWWPQMGEDVKCYISTCHLCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L325</accession>
    <name>A0AA38L325_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_278420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793620">
        <property type="protein sequence ID" value="KAJ3780970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L325"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="100" mass="11266" checksum="552F126DE80BC827" modified="2024-01-24" version="1">MINVPLEGVHSAPAPAEFKTVVGSDKIVQASKARRKNEAKFKCDLCDHRFTAKHNLQNHMNSHSNKRPHECQKCGNTFTTKGTHARHESICSGRAVRKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L397</accession>
    <name>A0AA38L397_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_390721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793574">
        <property type="protein sequence ID" value="KAJ3781315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L397"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="546" mass="62195" checksum="518DC155B52ABCF2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L531</accession>
    <name>A0AA38L531_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_289880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L531"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="37912" checksum="F1E8E7F67C2C36F8" modified="2024-01-24" version="1">MLPNSPRPKHGGLPSGPRSRSIGPSRQQNARRSDEGVPLPSRRVRQQRSVSSLALEMSAAEPPPSLPLSSESSRGWPRKYTPQSPQTPLSDDSMSPRLSQDSSSASSSVSSIFDRVKSGAASYASSLTSVEDSSKELDVQHSRERRKQRVLSPESVTSADRFETERTDTGTGDGYTVWNRVAAAASTLTISVSKAWASNVSMFPGEETPPGQESRLTRAMKAYHIDKARDPTELPEFLFAEHERQPRKRAEVKREVTPRNAGGTRGRTQESGGSEAAFTRSINRSTALNNSTEPSKQTQKGTDRLKALREAKRSQATSDTQVHTEQVASLLPRPKVGLPSTPGPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5G9</accession>
    <name>A0AA38L5G9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aryl-alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_375937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793346">
        <property type="protein sequence ID" value="KAJ3785320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5G9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041302349" evidence="6">
        <location>
            <begin position="28"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="462"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="619" mass="66789" checksum="474D61BFB0FA2F4A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5U7</accession>
    <name>A0AA38L5U7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein transporter SEC9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_287202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5U7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="286"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="349" mass="39781" checksum="82FC8CE13A76B585" modified="2024-01-24" version="1">MSFFWRKNSSSAIPPVEPAGQASGNNTSQPQPNTSTNRSSSYPSVNNSTSVRDNYNRNTNVGDVYTRGGANVDQDRNELFSGYNAQKSGGSGRFFDGPQGGLRDPPPGEENDEDVEGIKKQTRFVKQESVNSTRNALRLAREAEETARNTLNRLGDQSERLANTERHLDVAKGHSRRADDRTDELKQLNRSIFRPVIVFNKDGKRAAQEAQIQSRYQEEREERERTMMRVRETQDRIGRAQGYGRDNGDEELLGTRAGSRYRSAEQLSARKEQRKRFQFEATASDDELEDELDDNLDEISDMTKRLKALGMTMNQELESQNKHIDNIEQKAVNLDGRLFRNTERLKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6F5</accession>
    <name>A0AA38L6F5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_348990</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6F5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="15">
        <location>
            <begin position="51"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="699"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3787330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="763" mass="85409" checksum="755D468D0C50DEBE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6M5</accession>
    <name>A0AA38L6M5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_385531</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6M5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="922"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="540"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="632"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="832"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="874"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="951"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3787825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1190" mass="129564" checksum="D6AE08C6E4434486" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCT5</accession>
    <name>A0AA38NCT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_356165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3785011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="518" mass="56636" checksum="C2C8548CAACBF1EB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHD6</accession>
    <name>A0AA38NHD6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793808">
        <property type="protein sequence ID" value="KAJ3780287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHD6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="328" mass="36746" checksum="DADCA22CA439BED0" modified="2024-01-24" version="1">MQHVQTPSPAPVPLNPLFHESSLRRTRSQTACLSVNPPSSSSKSSSSSGSSFSRSSRELREVERLEREVAHLRQANAGLIEESASLRAQRDAAQAHAVFAGQQYSLYKYRYNEKTKKKDSSKRVTTSVRILTSNQGRKEIAEDSARKAEKKKAEEVRQRQKDDVRHSDIIRHAEQERLNAAFSGSLKSMTKNEELKKHPRYIGLFERIRKRKDPPTGNDSAGPSHRPPPSTPTCSPAPGLSSLRRSDSPESLRRSDSPELPSGSSSWRPMHHSGFVTAPQLNQAFFTPPLTQFSFPPPSYPPSYPPSYPPSYPPSYPPYPPLHRFPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHF7</accession>
    <name>A0AA38NHF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_229666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793733">
        <property type="protein sequence ID" value="KAJ3780467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHF7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="302" mass="35508" checksum="25E012CCB514712F" modified="2024-01-24" version="1" fragment="single">MRRNRIILMGIQETKLRENEHLELMEQNKVLTIYNNPDPNGKAAGGEAFLINNDLARNKNISHEILIKGKASRLLIQLGPNDRLNIINAYTPNNEKEKTEFFKQLTRKIRKLKENDDIILMADFNAVTESTDRLPQRRDDPKVEETLEKLIKQIKGVDGWREANPEKLDYTFTSKSNGSMARIDRIYVNKETKKNYSNWDIDTTLNLSDHKIITVFRNKENTPYIGKSQWKMTKDLVEYKPFKQRTGEILVELQEKLIEDRTCYKNPQQLWLKAKETITQIAMEMDKKRKAEINTKRKALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI57</accession>
    <name>A0AA38NI57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA binding protein Ncp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_335068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793441">
        <property type="protein sequence ID" value="KAJ3783002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI57"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36155" checksum="98B0F1B1A3A5080A" modified="2024-01-24" version="1">MTQDAQDPNLPISDVQESDLSREPTVAGGGTKLAPNAVQLSEVVDDDGDLEYADEPQLNDITAHPNGSEGWLPATDLPPPSDRALSPSSQPARSGSVLKKRRPGSIASKASSVHGGPTLDGVERNRSTRSVGSTRSRRSMFTNAEGKPVNGSTFINGAGATGPSATATADDSLHQRMQSADGALTGKQKKKIGQTEVKQGQRLSKVIKSESKVEKKSLEIAIQELGELQKIQKTAVKRESKAHTAHTKAVTAFHKAEEAYLAARTKYEIAQAAMQSEADNLEIARNNARGATENMQEKATEVDGLRKVFGVDEREREVMMNDLKGKPKDGKGSSFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIF9</accession>
    <name>A0AA38NIF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_399998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794436">
        <property type="protein sequence ID" value="KAJ3779658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28373" checksum="2995A5A68597F053" modified="2024-01-24" version="1">MLEEAVTYPPRDGYPLFLTAKRYWIPEFEIHAEDPEAWTLILLHSTASHKESWGPTLERLFHYYYLNCGYHALYYITQPIPSSPVTCDKYAEAIYHFLVASPDYGAKVDFRKRRLYGFDSITIVDPMLSPAGSHHLNKLRTILIKGAYERRDVWPDRVTAMKALRRRDRTKKWDPRILVVFIKHGIRPHPGSYYLENPYLGVTLACTRDQEALDPEGATKPVKSLNLACRENPIHLVLGGIHDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIN1</accession>
    <name>A0AA38NIN1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_358673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793387">
        <property type="protein sequence ID" value="KAJ3784187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIN1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="449" mass="45412" checksum="CE9BA7F98BAF8D83" modified="2024-01-24" version="1">MTVPVVPMPEPHVGSTANDTPAGGVSRMTAPVIPMPEPSVGSNIAGNTPAGRTSNSRMTVPVFPMPEPSVSSTLAGTPSGGISRMTAPVIPMPEPSVSHSGASPLAAEPFSMMSGSFTPGRSSSSSGPRFIPPAIPMPEPTVPQHDSEAGSQDIVSMPEPSVPQFGVNAGSSPAREPISRITAPAVPMPEPTVPRVVHRESTATPADGESRMTAPAMSMPEPAISAKALSKTQKKKQKKKGGISMPEPEVPQYNVSSTAQAGSSSVITMPEPSVPSFDTQSIIAPSGGASRMIPPTIPMPEPSSNVTAPMIPMPVPNIGTPLSMGGNVLPPSSPSMSTSGWGIGGSGGWGLDAGAGGSGGFGSPNMSNQRMSIHSMHAGTTPVTVSQPLPVPNPIPGPLRKGLGIKSIGSSPASSVDSTTRKNTEANKGSKGLQKSARARGMTTSAWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ54</accession>
    <name>A0AA38NJ54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger Mcm10/DnaG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_321099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793632">
        <property type="protein sequence ID" value="KAJ3780903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="3">
        <location>
            <begin position="397"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="744" mass="82138" checksum="0251B1A39370BFC5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKB7</accession>
    <name>A0AA38NKB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_349860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKB7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3787037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="534" mass="59302" checksum="21D4C92E3A0BFEB9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKL4</accession>
    <name>A0AA38NKL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter NIPA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_361423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793428">
        <property type="protein sequence ID" value="KAJ3783258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="702" mass="74171" checksum="65B05B24F52C3A94" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKM7</accession>
    <name>A0AA38NKM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_373952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKM7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="549" mass="60665" checksum="329BD59961429C31" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKR3</accession>
    <name>A0AA38NKR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_360841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793419">
        <property type="protein sequence ID" value="KAJ3783453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKR3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="259"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="679" mass="76620" checksum="A49EE71A479F7AEF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL41</accession>
    <name>A0AA38NL41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_346771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL41"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3788237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="174" mass="19071" checksum="61E6F729C28F198B" modified="2024-01-24" version="1">MRAIIQRVTSASVTVDNAVISQISRGLMVLVGIGTDDTASDASVLINKILNLRVFNDLVEPEKMWKASVKDIDGEILCVSQFTLLANTTKGNKPDFHRAMSAESSQVMYAAFLDQLRQAYQTEKIKDGRFGAMMNVSLTNEGPVTFTLDSRKFDYIEPSGTEAGTKRKPKTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLA6</accession>
    <name>A0AA38NLA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">GGU10DRAFT_359639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793399">
        <property type="protein sequence ID" value="KAJ3783904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLA6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="352" mass="38936" checksum="F68D18DE84482C1D" modified="2024-01-24" version="1">MDEEFPYYLQNIANLGGHEDRAWHIAWNPTKSLLASCSADKSVKLFTYNHDGEGNLNFTLATSIPTGHLKTVRAVAWSPSGRTLATASFDSNIGIWEQELDDDGNPGEWECASLLEGHETECKSVAYSSSGNLLASCSRDKTVWVWEVQPDSDFECMGVLMEHTQDVKCVAWHPTEEILASGSYDDTIKLYVDDPMDDWFCCATLTGHASTVWSISWSPNGKYLASASDDKTVRIWRRIGEHEFKCVLVLEGHERSVYSVSWGIGKSNQEIDSSLGWIASASGDGVIRVWDLSENSSTESMIPSAKLIARLPTAHGVHDINSVVWCPRKGHEDLLATSGDDGMVKVWRIQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLS1</accession>
    <name>A0AA38NLS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793352">
        <property type="protein sequence ID" value="KAJ3785133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="333" mass="37123" checksum="B5CC25FB52D0DCB0" modified="2024-01-24" version="1">MPSSQIPLDRAYLTAIWLETLFYGINLLLFFSYLFIVRYKRRTSLSKIIVGVAIMMFLFSTVHVSLGFYRLVEGFIVLRNPTEFFSDVSIPANVAKVTIHTVNSILGDSIMVWRCYNVWGQRWTPSILPILLIIASAVCGFGQAVIFAEARTTHSAFGSNLERWNGSLFSLSLATNVVVTSLIAARIWWVNRQFNTYHDSSFKYRRVLILVIESGAIYSSALVIEITLYFLNNNAFYIIYDPIAQLTAIVPTMIIVLTSLGLTSADLNSEGQRTTRNRMTGIESRPQFAATGRGGNTLSSMGSTFPESEDHIGGPGADMVLKLKQKESAEVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLU2</accession>
    <name>A0AA38NLU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_269609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793348">
        <property type="protein sequence ID" value="KAJ3785253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLU2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="57"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3785253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="497" mass="55128" checksum="CE62C059134FCD3D" modified="2024-01-24" version="1">MLFRGTFVQCPSLGELEIFDDWLIAVDDSGYITHFEPAQSSDLLRRNEPINLPLGTFLLPPFNDLHLHAPQFLYQGNGLDLPLLEWLNQYAFKAEEKLDCDPGLARTVYRRLGQRLIKAGTGAVCLFGTLKEETNIILAEEMQSAGIRAFVGKVSMDISSRPSYIEASSSVAIDAAREFGEKVDRTCSVPSSTTSQSRPQLVHPVITPRFVPTCSDELLHGLGALSAEKGWRIQSHMAESSDQVEWVKKERGDDDIHIFEKHNLLTPRTIQAHCTYLSPSSAPLASQRSSQDPFILLHHLGTAIAHCPLSNIYFSASRAFCLREALEAQVKVGLGTDIAGGYSLDIMSAMRTAVAVSRVREGERDRERMALQNVDTSSNGKSLAIDWKESLFLATLGGARALGVESGVFKVGAPFDAQQSKILKNATKYHTSRSRRIGAGALDSFEMDIEAGRNQEKDYKKQTCITKEMIERWWCIGDERNREAMWVQGIEILGSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLZ2</accession>
    <name>A0AA38NLZ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carboxypeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_354229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793336">
        <property type="protein sequence ID" value="KAJ3785613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="308"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="621" mass="67677" checksum="43570E56329CE695" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM16</accession>
    <name>A0AA38NM16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NadR/Ttd14 AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_353828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793332">
        <property type="protein sequence ID" value="KAJ3785763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM16"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="168" mass="18878" checksum="D14B148278BD7FFA" modified="2024-01-24" version="1">MHITEVARTVMKEQGFTRADVHSFAMQHAIVKAQVAKDWEARQNTTAENTTLGQPILLSDRSAVDAVVYAALSELTTKSGSTQALISSSDFQEVLALYRSARSTFVLLRPIKEWMVDDGVRSLEDGEHCYAMFVKVLRELNIPYIELGESCRWLEERVAIVRRATVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM43</accession>
    <name>A0AA38NM43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_332756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793328">
        <property type="protein sequence ID" value="KAJ3785928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM43"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="339" mass="39343" checksum="7A20CDA04699B288" modified="2024-01-24" version="1">MSDDELQALIMNIDRNKDLIGEMPEIDIMGSPQVFRLKPYALAAKYVWTDCRNEVYTMQLVHQHTTIPVPQVRRVLPDRAQKTGFWLVMDYIDGDCLLAVWPKLGWWRRLQVVCALRSYIQQLQRVPLPSQSIPGPFDGTGSPLPCLGGHFRESSGPFPTYAAMAAWHDEQNHRYQVLSNHGTYFWPYSKFDTSAPLVLCHFDLHMRNIMLDRNNQVWLIDWAFAGAYPPWFEYVPFGFWANAASPDRRSPRSFVRFIGFIVGGCASWYFNHYITEFDHRPMGFRDCIIDQDYFVKQGIDPKLYQPVDVARPSLRRMMAQRCLDIFYDTVLTVKGLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMR7</accession>
    <name>A0AA38NMR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794652">
        <property type="protein sequence ID" value="KAJ3779555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMR7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="219" mass="24549" checksum="16F56F515FD564B3" modified="2024-01-24" version="1">MSFGSDPQDFIQYALSLPDNISDDSSHESEPFEPYTNSNSEIDSTASDMESNASNDASDTSEVASWDEIIRRADPRYRHRFLRHMMDYYTNPDPDVGPFDYSDSEFNYSHDSLVNSAHSSDSFHSAHSSIAGSESGESSHDNGLESSPEPPDYMGPDGRLLESERERRRNLSLCFYCGGDHFRSHCPKLRAKYSGASDASQSDFSEEAFDPDFDQDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNV7</accession>
    <name>A0AA38NNV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_99998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793535">
        <property type="protein sequence ID" value="KAJ3781655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNV7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="208"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="568"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="741" mass="84557" checksum="B376CDAC9C1F9B4F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP57</accession>
    <name>A0AA38NP57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_317308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793434">
        <property type="protein sequence ID" value="KAJ3783155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP57"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="306" mass="34018" checksum="6724AE21F927E388" modified="2024-01-24" version="1">MTDTTSNAAATAAFEHFIKFRMQYSSLAVLYYDYVLTFADEIRYIWRLRSLTQISTLLYICCRYALPGNLLYLLANTGTLGGIDRCDTWYRIIAALSVMGRASIIKGNLLSIMIPVYDFIAATITIARGIQAIRKMPRTAKLQDSLYYLMVEQGVIYFLAISAITITQSVISFRPVDPSGAAAFIGQINAFSVPVSGLLIARFLLRLRAAQEGFNTNSEDLHRENIDIASTVRFADRDAFLSTSTTGTDIFASPVGESGHGTTSVSTLRQVIDSVMNEFGDDPVERTKDMLERTESRRVEQNRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP94</accession>
    <name>A0AA38NP94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_403814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793407">
        <property type="protein sequence ID" value="KAJ3783710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="802" mass="90158" checksum="5E177457504F3350" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPK8</accession>
    <name>A0AA38NPK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793342">
        <property type="protein sequence ID" value="KAJ3785420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPK8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041242842" evidence="1">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="194" mass="21743" checksum="FDF6DFB7C601A3F2" modified="2024-01-24" version="1">MSPLPLKIFLISLICIANMVVVNTGPVTRVQKTAADNLLAKRDGPLIGYLTFLKEEDAVLFKGGKFPDMQNHKGEWFPYPIYSHPGSNSFFRCKVFDTRGLLEIMRDRKEARYYSTSAKNAMQTASSSAAVITPVHSSSKSELQMFVPKSLLTKYPPSVDCLIGEDEAIPVANWRDLKLNLPDQYDKELGEQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPL3</accession>
    <name>A0AA38NPL3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_195492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPL3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="281" mass="31585" checksum="136DA46D93E6AF12" modified="2024-01-24" version="1">MASNNGSLLTNPSWPSLYNPRSELFDIEHHDPIQPGGFYLVNSQDVFRFTLYWTLVFYIPVFFIFGSYAFFNLTFPPKIDQERVSKVFEEFHEEEQEMGLEIGNEEEEGDAEETYPMSPVSSYLHPRSNTRNGYYDTLRSEITATSTSPLAPYLRSPTSATANHPFLSVSSAHGHPPPPIPSIHSPTITRATRSARDSRKKNKPPKNAARSRITFALLVFFGFLLLSLIGAVVSSAIVGYILTGLYKAGKFYMSTWVPFLWAAISVMVGMLNVWPSVINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPP2</accession>
    <name>A0AA38NPP2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_427711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793328">
        <property type="protein sequence ID" value="KAJ3785930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPP2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3785930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="284" mass="31225" checksum="676B7B45D90B9D98" modified="2024-01-24" version="1">MPSTSIEDFRGILSNARNILVVSGAGLSAASGIATFRGQGGRWRKYDASILATLAAWHENQSRVWQFFHYRREEVRSKRPNDGHYALARMCMPKWRRTVAPNATIVHVTQNIDGLCLEALDELSSASEEPPDGTIIEMHGNLFDVVCTAFDCDYRAKNMDYPICPALGGTEAIVAAGNVEPVVRRADLPHCPKCQQLLRPDVVWFGERPKQIQRILEAADSADLCLVVGTSSLVQPASKLPERVHANGGKVAVFNLEPNTNHSDEADFEFVGPCESEIARILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPR2</accession>
    <name>A0AA38NPR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_177186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPR2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="229" mass="26486" checksum="A0361DD6F24C192F" modified="2024-01-24" version="1">MNGVEESGRYGGPYNGPRRSSRSRSPGGDNRDRDRDRDRDRDRGRRDGGQDNNPGNNLHISGLSTEVDDRELEATFAKVGRITKAQVVYDPHTRESRGFGFVTMETPEEADAAVTALNNTELYGKAMTVAKARRGRARTPTPGKYFGPPKRRPRDRPYDPRPYDSRYSRDRDRDYDRRDRGDRAGRYDDSRRDRDFDRPRDKGGDRGDRDRYRDYDRGDRPRGPPRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ68</accession>
    <name>A0AA38NQ68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High-temperature-induced dauer-formation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_306835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="912" mass="101675" checksum="63D64F38E17DE1A0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQP9</accession>
    <name>A0AA38NQP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_343511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQP9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="254"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3789365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="410" mass="44687" checksum="7FF2C5169E31BE5A" modified="2024-01-24" version="1">MDPPASVDHKEPARKTLPRKRSFGKYPSSKVTDSPAYDASEEDNDPTDVDDAASAVSVSGPSSSSRARTLAAAGLLKSSSNPAAHRKHHLASSIVSDSDGVDSPTYDGDIESSTTAGPESPHPHSSLRLGHHHSMSSHSTLNTPAYPGSETTTDYIETPGTEEPRTAYPLNATSHPLFITPPSDPFPHPQNSISEPAVPSTIPSALSFNPAALRPEDIQLFVQRAIDGAPVEGSGVQRAYKINRPPEDRPVRVYADGVYDLFHFGHALQLRQAKLSFPSVYLLVGVCSDELVIAHKAKSIMSHAERLEALRHCRWVDQVVPEAPWVLTPEFVEKYQIDFVAHDEDPYKAEGLGQDDVYEWVKRAGKFLPTRRTPGISTSALLERIVDMYKDGIMDRKLEGMGRGDLTRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQY5</accession>
    <name>A0AA38NQY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA photolyase, FAD-binding/Cryptochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_431680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQY5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="8">
        <location>
            <begin position="67"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="346"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="390"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="515"/>
            <end position="517"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3789473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="615" mass="69381" checksum="AD7FF321EDC41435" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRT1</accession>
    <name>A0AA38NRT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_342206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793255">
        <property type="protein sequence ID" value="KAJ3789904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRT1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="216" mass="24452" checksum="8CB273BC360DF9F8" modified="2024-01-24" version="1">MYSQHPPAYGNSHHHHGSIHSTHSSRYARQAEYGYQAAPPPGTDPTLWAYFTGVDTDRSGSITANELQQALVNGNWTKFDLDTVKMLMSIFDVDRSGTINYNEFAGLWKYIQDWQNVFRHFDRDHSGTIEGHELSEALRSFGYNLSPDLLRLIEQKYASAPVSGYGPPPGITFDRFVRACVVVKTLTESFQRADVNRTGYVQFSYEQFMSIVLSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS31</accession>
    <name>A0AA38NS31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_283067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS31"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="136" mass="15719" checksum="81F5E2C31362C00E" modified="2024-01-24" version="1">MVKVYKPGKVAIVLQGRQAGKKVVVIKQLDEGTKDRPYPHAIVAGIERCPRKVTRRMGQKKLATRSKVKPFIKVVNYSHLFPTRYQLELESLKGSVSAETFKEPSQREDSKKAIKKQLEERYTAGKNRWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSG3</accession>
    <name>A0AA38NSG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_179437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSG3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="213"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="451"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="520"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="603"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="912"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="989" mass="109614" checksum="F5286EE8E10A2765" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSH1</accession>
    <name>A0AA38NSH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_178497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="130" mass="14448" checksum="7009FBB304E0B7E8" modified="2024-01-24" version="1">MMDPPYYILFSTQPASSSSLGHPTIQYQYADDSPLALLPQHPDEHVLLLDYDQTSPVPTVNSTSRTLAVTGIKVEEAPGAAVAENRHNDRMYIIEGTTVPVEDKLLQLSSERPSPHVIIAQFKQRKVDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSW0</accession>
    <name>A0AA38NSW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_258411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSW0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="223"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="625" mass="68803" checksum="7FB1CA0CC7E76CDF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTA1</accession>
    <name>A0AA38NTA1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_129505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTA1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="14">
        <location>
            <begin position="167"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="15">
        <location>
            <begin position="389"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3790746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="499" mass="54260" checksum="D9BECE980B733F0B" modified="2024-01-24" version="1">MDPTLNPTVVSAPGKVLIAGGYLVLDPAYPGIVISTSSRFYTVIRPLTPSTTNTIQVRSPQFNASTWKYTLSCDLSPKVDAHAENTSKNKFVHLALQNTIALACEVRGITPVLDILARGLDIAIVGDNDFYSQRAQLTALGLPRNLASLAQISPFSPQNVTLSEVHKTGLGSSAALITSLVSGLLVHLGVIPSSALLEDEGRDRQLAHNLAQFIHCLAQGKVGSGFDVAAAVFGSHLYTRFDPSVIAPLMGDDSIQPKSLLQVVSPDNTSWNYRIRPFQLPPLTRLMLADVDAGSDTPSLIGKVQNWRKAEPEKANAVWTAIDKLNQSLASALSRISNFHSQSPGRYASIVKFISTLQPLQWTADPSLPEFETQVASEFHEAHRITLAIRRSMREMGELADAPIEPPEQTKMLDKCCAQAGVIGGGVPGAGGYDAVWVLMCEPEQCWPDQWPRERIEYLWSNYTELDVSPLSAVESMAKGVRLENIDQIQGLKEVTQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTD3</accession>
    <name>A0AA38NTD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferrochelatase</fullName>
            <ecNumber evidence="7">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_129527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTD3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000001">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="38404" checksum="D725701F7C9856E9" modified="2024-01-24" version="1">MQVAETHDFLRNLFSDNDLIPLPLQSILAPYIARRRTPMIERQYADIGGGSPILKYTQIQGEGMAKLLDELHPQTAPHKAYVAFRYARPLTQETAREMKADGVTRAVAFTQYPQYSCSTTGSSLNEIYRKGKAGEFGQDVSWSVIDRWGTHPGFIEAVSQRIEAALAKFSASTRSETVILFSAHSLPLSVVNRGDPYVLEVSASVSAVMQRLGQSNPYRLAWQSQVGPSKWMGPQTSDALKGLSRLGRKQVVLVPIAFTSDHIETLYELDLEYMKEARELGIEIYRAESLNDSPVFIRALADIAADHLRSQVSGKHGPTSIQLGLRCPGCVNATCGQKKSWFARGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTJ7</accession>
    <name>A0AA38NTJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_302491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTJ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="56"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="12">
        <location>
            <begin position="410"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3790808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="667" mass="74530" checksum="00ED17A67D2B40A9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTM6</accession>
    <name>A0AA38NTM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Indigoidine synthase A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_339106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTM6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="376"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="696"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="772" mass="82724" checksum="7D41F79B57157A60" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTZ9</accession>
    <name>A0AA38NTZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_65908</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTZ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="445"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="686"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="15">
        <location>
            <begin position="815"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1000"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3791121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1074" mass="117756" checksum="AFA23FBA4F7D56A1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TXW5</accession>
    <name>A0AA38TXW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_330157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TXW5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="541"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="593"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="635"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="6">
        <location>
            <begin position="730"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="909" mass="99528" checksum="099789C611228DD9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZP7</accession>
    <name>A0AA38TZP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_341172</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3790139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="143" mass="17110" checksum="6F951BA58AE37BFA" modified="2024-01-24" version="1">MIRFILVQNRQGKTRLSKWYVPYDDDEKVRLRGEVHRLVAPRDQKYQSNFVEFRNYKVVYRRYAGLFFCVCVDANDNELAYLEAIHLFVEVLDSFFDNVCELDLVFNFYKVYAILDEIFLAGEVEETSKDVVLTRLEELEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U121</accession>
    <name>A0AA38U121_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_370809</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U121"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="312"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3790962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="430" mass="46598" checksum="2A5FA3CB1563380C" modified="2024-01-24" version="1">MHDTETPYQVMTLPSKSDLVDRFVGKGLDELRTPALIIDRKVFAANCAAMHSKAKQWGTAFRAHLKTHKTVEGTRLQMISSADRTSAVIVSTMMEAWEVARNGLFKEGTVKDLLYGLPVAPNKVADLSGLWDEVAQDGGIVRVLIDHPDQIKFLEDCESKRQKPRKWSVFVKIDGGQKRAGVSPGTSNFENLVKALLASPVISIYGFYAHAGNAYASTSLDQASTFLSAEVESVNAGAELTMKIASALGVDLDSRSFVLSVGSTPTAHAASAENKAKLSALLHGSLELHAGNYPMLDLQQEHTNLIDRSKVAQRVLVTVVSCYPGRGLNRTDEVLVDGGAIAFSKDTGPSGSFGEVMGMSWKLGRISQEHGTLTREGPVGNEELKVGDEVEIIGQHACLIAAAYPWYYVVDTDLDGGKKVVDIWVPWKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U146</accession>
    <name>A0AA38U146_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_328895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U146"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041413981" evidence="2">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="209" mass="23000" checksum="E1163818F7C4DFF4" modified="2024-01-24" version="1">MGLSFTYVLTLCIGLFAVARAVPVSMTPGNAATKLSQVSPRRVAQRPSFFQDSLPSESNHDLSNNYPSPHSEIQLPLNQTSTRFQLIFLPLPGGNINDPTTSEHTKRITSIVRRYLNQSGHYHGLSRDDFTLVNGWDGDAHGTGAAVVEFRIEDSARNGHCNSFCLGMVDVPYDTEDSTESIHGTLAQDQFQLFFDHAQSRISSTLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1M4</accession>
    <name>A0AA38U1M4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_370541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1M4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1012"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3791260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1098" mass="124429" checksum="B3D097E877E8DA90" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U7E4</accession>
    <name>A0AA38U7E4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_258416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U7E4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="369" mass="42254" checksum="EED60D59937BABD0" modified="2024-01-24" version="1">MSARNANPLKVSLLKQIHNIINCLVNIKDETGEFLMTLEDGRVIDTKGWNDWEWTHGIGLYGLLKLHKITGDVHALDISLAWFRERFEIGTTKNVNTMSPLLTAAYLHEAKKADYLVHLDSWAEWVMYDMPRTEEGGLQHITYLVVNYQQLWDDTLMMSVLPLAKIGLVLDRPHYVEEAKRQFLLHIKYLQDIQTGLWFHGWTFDGRHHFGKARWGRGNCWVTVAIPDFIEMLNLPETDGLRRYLVTSLVAQIDALVKCQDQATGLWHTVLDDENSYLESSCTAGFAYGILKALRLRLIPKEERYTNSAKKAIQGVLANITPEGELKLVSFGTPVFDNIEEYRRVPLTSMPYGQSLALLALTEYLRTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7E4</accession>
    <name>A0AA38K7E4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_6609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794280">
        <property type="protein sequence ID" value="KAJ3779739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7E4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000018">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3779739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="290" mass="31598" checksum="064DF51F7CBDC148" modified="2024-01-24" version="1">MSTSTNIEIQKATAERTAEIRESLADIRARVASAAQALAVNSESRKIVAVSKYKPAADILVCYEYGQRDFGENYVQELVDKAKELPSEIQWHFIGTLQSNKAKLLASVPNLHTVQTISSEKIANALNKALPTNRNTPLNVLLQINTSGEDSKSGLSPLSPSSFDSSQLSDVQKLAKHIVTLCPNLHLQGLMTIGALDLSLSANEMERNADFERLKQTRDILVRWLQDGLGSSHDGVNVGKRWRWGDESTGKLLLSMGMSSDFEAALKAGSDIVRVGTGIFGSRKTKLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8R8</accession>
    <name>A0AA38K8R8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_363270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793464">
        <property type="protein sequence ID" value="KAJ3782619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8R8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041460850" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="50203" checksum="E8B816FF1B3A0848" modified="2024-01-24" version="1">MACMADLPAELLASIFLLAVFACDGVPALRNAPWNVCQTCRLWRSITLNDGRLWAHLQLYKVDGLCYGDEDGQQILIGPDGGLRLLRIWLNRSHNAFLHYFVNDLTSYSRRALHLLLDHQERWKDMGFNLAGLNYWQRIRLTTLPVAESLLVEIDSMESQDTYDDVRNTPHEFEVPFSTSSFVGVKVKGPLFTFPQSAVKVTDAVAPHLTELGLRFNETLTSYNLRLFTMPLLQQCPVLQHLKIDFIPNDEQILDEITTILTLPHLRSLQFFTKYNSFTSFLRHIDAPCLESLDVETRSIYVDGAQRRVVNDVLHVIRKTASTLSNLRFIHDTKLNFYHELFPLIQGTVTQLDVPHAHQVLEYITAVSGLGNLAVFPNLQVLIVTVDGSTTEECIHGLNQLMAALTGHSRLRFVATTMLPEYERDEVLGQLCREGRLRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K968</accession>
    <name>A0AA38K968_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">STE like transcription factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_46896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793408">
        <property type="protein sequence ID" value="KAJ3783684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K968"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="559" mass="61417" checksum="ADB3A32C315D9678" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9L0</accession>
    <name>A0AA38K9L0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_401625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793377">
        <property type="protein sequence ID" value="KAJ3784434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9L0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041334535" evidence="1">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="38"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="323" mass="35647" checksum="7993270A34354855" modified="2024-01-24" version="1">MLSQNFFSILIALKFIPALSQSYTQNAHFKGRDFLGAFNWETFDDPTHGRVNFVDQGTALNTNLSYADNDVFIMRADYHQIVPSYARGRDSIRITSHDAWGDSLLILDLAHMPEGCATWPAYWTMSKNGPWPQGGEMDIIEGVNLNSNNLASLHTTTNCTMPQTRDQSGQVISTNCDAAVNYNQGCGVASTTPNSYGSGFNNNGGGWIATWRSPNAISHWFWPRNAPNVPDEIRQGDCGVVTPGDNWGTPDATFVWSQCDYSSHFDPHQIIFDLTLCGDWAGNAFPTAGCGPGNCQDFVDNTPDAFQNAFWEINSLTIYTPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBG2</accession>
    <name>A0AA38KBG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_279857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793907">
        <property type="protein sequence ID" value="KAJ3780118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="3">
        <location>
            <begin position="135"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="658"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="916" mass="104211" checksum="807426828AADE9ED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBU7</accession>
    <name>A0AA38KBU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1014-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_346679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793277">
        <property type="protein sequence ID" value="KAJ3788319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBU7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="130"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="247" mass="26870" checksum="2F4233C161BBF509" modified="2024-01-24" version="1">MAPKGGNSKKESGRAKKAENEAKKQEAAATEKEKKEATAWEDGAKNPKDKAAKEEKRKADLARKAENAKLLAEEEASAPSKAKAAPKTGAKKVTKPQPKPAGPGAIAAGGGLGSAEVEEGDKGEEGPKEVESFHATGIDNALDLLEVVTAKMDKASVGSQAAGIERHPERRFKAAFEAYQERELPNIKKEHPGLRLQQYKDLLYKQFQKSPENPFNQTTVTYDASKEEKIHALNAKKAQVENRLRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCJ0</accession>
    <name>A0AA38KCJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-butyrobetaine hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_397189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793522">
        <property type="protein sequence ID" value="KAJ3781813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCJ0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="155"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3781813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="444" mass="50831" checksum="79EBDEA8A706AA31" modified="2024-01-24" version="1">MTYSFSRRIISKHLRALRRSITTATINDDSLTIPSLNNATFPYIWLRDSCNSRECKHPETTQKLHSSTDFDVDIRPKLVKIVEDGKPEGERGIHIEWPDGHISFFPESFLKTHSSKDYLAGFRKDVEAETWDGKDIETSRDLYLHHDEIKTSAGLLRAIDQLCRYGLLFLKGVPTNTTPTDLALTELALRFSTEIRETFYGRIFHVQNINSENIAYTNLKLGLHMDLLYFEHPPRYQILHCIRNRVQGGSSIFSDSFHAAKLLKSFYPEDYDILTKTPVPFEYRFGDHHLHFSHPTIEEDLHNPALQCPPIKCINYGPPFQAPLLLSPSSSSSLSSEISSSSSSSALRRFYLALRRFANLVNSPELTYEYTLQEGDAVIFDNRRALHSRTAFTNLDVEHKRDGSSDSQGKKKDISRWLQGCYFEGDAMKDRGRVLRAKKTAGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCS1</accession>
    <name>A0AA38KCS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_248520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794446">
        <property type="protein sequence ID" value="KAJ3779651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCS1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3779651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="210" mass="23751" checksum="776C67866D6C8B17" modified="2024-01-24" version="1" fragment="single">DGLHKFKDWWLKVQSGKDHEHESSSPFRKRFKKKFKNLYLPAEWPNPAVRDAYYHPTVDSSDEPFKWGLPDLDALRAFLNDELSWNQAKVDDLLLPIIQKVGKRGQVNTMNRQGNLNNFFDVSAGGGSVAPRKRQAYASKRLQQVVSDFRKTRKSVSSFSTAESSSEDDVEQSAEGDEQPPTKKPRASTKGKEKVSNTGTRSKKPAARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCT5</accession>
    <name>A0AA38KCT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_389861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31980" checksum="50DFA4E4E54FC53D" modified="2024-01-24" version="1">MPSATLDTVPGTLFYFTPPADGSEPYNRVNTDPTSTIPLSNWTPQKYTVHIENVRGKEALFTLDEAGFQYFKHPARYTSFKDDNEIKAEYYPESADLIQKITGASRVVLFDHTIRRRILGQVDMVGKRQPVKEVHVDQTASSAISRVHLHLPPSEAPELLKHRFQIINLWRPISHPAFDMPLTLCDYRTVDKENDLAAVARISPERRGETYRVKYNPQHRWKYLKGMTPEEFVLIKCFDSTKDSGVSIFTPHTAFLDPSAPEDTLPRESIELRALVFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD47</accession>
    <name>A0AA38KD47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_68680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793445">
        <property type="protein sequence ID" value="KAJ3782938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="176" mass="21211" checksum="8525EBA886F9B7EE" modified="2024-01-24" version="1">MMTSTTCSSLSLEEIYTPPPEPATGDPDHDEDCPPPGKHLPNELRLDRKRLKRDAKYRKPEKLFYGFGVNIRDCLEYHQTHHLPLPKYRTKHMLWLSIMKDVVKHLRQICRHDFQFVMPRAYYDMEIALYDSYTIHRENLARDEEEDVIRLLRQELDVCKDQEPRWYYSRIDLCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDI2</accession>
    <name>A0AA38KDI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_243510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793413">
        <property type="protein sequence ID" value="KAJ3783583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDI2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="332" mass="38270" checksum="55B8A4C56B63CD60" modified="2024-01-24" version="1" fragment="single">VCQLFGKHNIFNTNHSQWIRKDKDKLRHWATAYRDAQTLKERKSISETYGVRWSSLWLLEYWDPTRMLVIDSMHCILEGLVRFQCREVLRLDASKRQVSPKGFKYAFDWQWALYDPDIAIHVEISPKHIPQVAKIQDALCWAIEGEQSLSLDELWTRLDGNVSGALQFVAWSLELSPLLNNIHPDISSLYVERAKRKSKRRSLVDVQFPTGKPPSQKNHFIALLLNWRLMQPRDASKFVVETGRPEVLTYIRQVIQKTTTPAWLNSVPKDFGDPKAGTLKADEWRTLSTVYLPIALITLWGDIDSSAPPENDSEAAYLLKALDHTMALFQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEB2</accession>
    <name>A0AA38KEB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_313611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793353">
        <property type="protein sequence ID" value="KAJ3785083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="764"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1241" mass="138822" checksum="7E44FBD22E3F84DB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEN2</accession>
    <name>A0AA38KEN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_193705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793337">
        <property type="protein sequence ID" value="KAJ3785593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEN2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="349"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3785593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="909" mass="95736" checksum="A806489A00AECD85" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEW4</accession>
    <name>A0AA38KEW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_186375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793330">
        <property type="protein sequence ID" value="KAJ3785833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="558" mass="62741" checksum="283F2C96AACD4A66" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFL4</accession>
    <name>A0AA38KFL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_332066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793306">
        <property type="protein sequence ID" value="KAJ3786778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="350" mass="39616" checksum="1C791FEDD807556A" modified="2024-01-24" version="1">MPHGHCQILPCGHGGCSSCLDQIFDLVTQEGACWMCRQEFHRSRAHRIYIEVVDSKVAVLQGTIEGLEKMDAKVPVISVERASQRLKKTAQEIECDNEKAKSLQQAIKDFDERIVPVFKDVRAQAKELKQLRDQLSRAKSRAQAFDEIRESSERKDLLINALRSELDQSKKDGQQRQNELDMQDKKKKEDDNWKLRGTLERQAKDARSRKVKIQALKEEISDLRKRNESLEESQSVALDESLPVFMSDDYVDNNFLPSSSSAQVAPSPGRVRKKYRSFGLSQITNELHLANVDLDFDSGMPGPGFSSDWKMSGTVTKKKAAPTNFPIPLDKHGRPTVSVQTGPVRSRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGA2</accession>
    <name>A0AA38KGA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_387416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGA2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041381501" evidence="2">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3785501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="146" mass="16118" checksum="683C170F028EA321" modified="2024-01-24" version="1">MQILSIYIYLGFILGLFATVQAAPFGSEPGFENLSQRSRDDEPPAQPAQAGLVTQQTGHSHVIVHFTSFALDPHRAGTNVPAEVSHRLANYFHEHESDILLDDPVNQIGYLPGTMWPAGRSNRVAVDFVWARSLDSPFTHGHLEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGG1</accession>
    <name>A0AA38KGG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_346731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGG1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041215595" evidence="1">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="212" mass="23227" checksum="FBA5DFD2027A00CD" modified="2024-01-24" version="1">MRLNAQATTRLAITILTLVSVVFSAPFTKNREAGNDIDSSASFSGNTSPSVSRRGIFHTCSVTFDQADHVSQVATVDSKTNDLAQQWVIRLLDEAEKRMGLNFSCNVKFINKYKGILFSGNYRYPIRFHLEDEGKEPICGLGSGGYGCSGSIRWDKSARFTHPYNAIQINSQEGGAIFQNNLGKIGVGSMWLGSVDWSKGASQGSKPPQRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGY4</accession>
    <name>A0AA38KGY4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_408565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGY4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="215" mass="23778" checksum="FEBC5CBD1C245BB6" modified="2024-01-24" version="1">MMISSFLRPLSRSRVRFQRPISSFIIHEPSSSAPRIVPTPLVFVSATSWDQSSSRQGFTVLAKMYSEKGYTCLDTDLSLAAGRNPANVMEDFESELKSVVKASFNPFPPVFFSRGATCLITQTYISSNPASGLVLISPPSSNNSLRSSLLTHALPEFNFEPKFPIAIVDTPQGMAELQAENRLAKDNRVDKIVVNDVEGQDAFVKIEQWMDEIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHY1</accession>
    <name>A0AA38KHY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_346068</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3788516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="330" mass="38929" checksum="11ED571228485CD1" modified="2024-01-24" version="1">MTEPIRYADRPEWSDVAPIEQYENTNPLAPIFYTNEYKDATNYFRGIVKIGEKSGRVLELTEHIIRLNPAHYTAWQYRYETLIAIDSDLGKELELMDELAITHLKTYQVWHHRRLLMLKIRKPFPELEFIARTFKVDAKNYHTWSYRQWLLAYFNDDELWGAELDFVEDLLYADIRNNSAWHHRFFTVFQSGVHQGEEDRERVLKREMIYVKQSISLVPNNASAWNYLRGILEHNSTPYSKMITFVEPYTLSMDEQTADLVDLDNPPPSKGAHLPCALAIEFLADIYEVQGGESMLKATELWKSLGNEHDVARKKYWEYRIREGLRALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KI31</accession>
    <name>A0AA38KI31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_409357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793269">
        <property type="protein sequence ID" value="KAJ3788801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KI31"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3788801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="24536" checksum="1600D8FC1077AF80" modified="2024-01-24" version="1">MPPQHRQASAWLKAVNLLKSSTTPGWRYVYWFPTVFVVSYYFYNLKIVSGRSMQPTLNPDASLWRDVGLFNRYAIHTKLDFNRDDIVALRSPEDPNRILVKRIVALAGDRVKTLPPYPNPEVVVPQGQAWIEGDEPFHSDDSNRFGPVPLSLIESRLVAVVWPPSRFGHQFQPTIVDKDISNPNKHSAYRLAMAELERQRWRTTRVAAAPRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKL4</accession>
    <name>A0AA38KKL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794471">
        <property type="protein sequence ID" value="KAJ3779640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKL4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="554" mass="61612" checksum="B6A0B9683CDE5E54" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLC9</accession>
    <name>A0AA38KLC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_391143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793680">
        <property type="protein sequence ID" value="KAJ3780645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLC9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="291" mass="32557" checksum="0A04CB56D5955843" modified="2024-01-24" version="1">MTEEHVPQRYYPSTQYLLPADQEEVARLNEQHRIIIKAFEDKLSLAPLSLNTGDKVLESAAGSGVWALEFAAENIVKGVEVNIECIDISAKQYPVTYPSHIHFSVHSVANLPPEWSNTFSYAHQRLIVLAMNDTLWRSATKELFRVLKPGGWLELIEFETKRFHCGVGPSSNRLCSLVDKLFTEKGIIQNVSDYLCPLLKEAGFTDIRCQTRDVPVGGRRIIEGGNGYTGEQWGEGWMGIKVPVLTGGGYGVANTTEEFDALVQASVREWNDSKEVYTIFYVITARKPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLU2</accession>
    <name>A0AA38KLU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_367079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793570">
        <property type="protein sequence ID" value="KAJ3781350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLU2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="203" mass="23289" checksum="046DD40F5831765A" modified="2024-01-24" version="1">MKKPTEKIIERILRISSTIVPNEIRSPSPVQSSASSSPNSVWNSHLGFHHDFYYFRNHPFISSSICFPNPKAMMPYIPTYAQIFRSAPLPSWLFYYLHEPTDSHSDFQGVKGKPDARSRLGTRSLDPTPLEIMIKRAWVASNFTNYTDFPNSADYVEGEAGKEVQARLGELGEDEDEELQRLQQLLRMFEMEVEGAWKEMVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMM0</accession>
    <name>A0AA38KMM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_57762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793429">
        <property type="protein sequence ID" value="KAJ3783239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMM0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="39105" checksum="D33839DBF3EA089E" modified="2024-01-24" version="1">MNGKSKISHVRLGRSGLKISRLILGCMSYGSPEWQDWVLSEDEGIKHIKAAYDAGINTFDTANVYSNGLSEVVLGKAIKQHNLPREEIVVMTKVYFAVGKTTDAITMSKNTPELDGSGYANQYGLSRKHIFDSVKQSLERLQLDYIDLLQCHRFDSDTPIEETMHALHDVVKAGYVRYIGMSSCWAYQFNIMQNYAIQNDLTHFISMQNHYSLVYREEEREMFPTLKYFGVGSIPWSPLARGLLSRPLDHQTKRGQSDRMIKAHGAADATATIVNRVEEIAKKKNAKMAQIAIAWVMARDGVTAPIIGTTSLDNLDELLAAVDIKLSEDEIKYLEEHYEPRSIIGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMS0</accession>
    <name>A0AA38KMS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 92-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_76956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793465">
        <property type="protein sequence ID" value="KAJ3782610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMS0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041290714" evidence="1">
        <location>
            <begin position="22"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="28"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="311"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="832" mass="89207" checksum="A367146D1C52811D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNA0</accession>
    <name>A0AA38KNA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_391198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793704">
        <property type="protein sequence ID" value="KAJ3780546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNA0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="1">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="193" mass="21525" checksum="B46A4862C018D51D" modified="2024-01-24" version="1">MFLKSLASQRLGSCSDIVKTARCHSSRSARPSQLAKQHSQRGGQNLSDRYIRLAKSLRGKETLEAEYENIHRSVLSGSNTGRLPAAGTGVVAYRGIIIPEKPKKPQSDECCMSGCAVCVYDLYEDSLTAYREAVAKVTGALKSMEVPEADWPRNLRTSERNKDVTLTVFEQMELEIQRRKQDKLDTNSGSARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KND9</accession>
    <name>A0AA38KND9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_429090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KND9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="74"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="226"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3783300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="568" mass="63367" checksum="0126036764356A87" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPH4</accession>
    <name>A0AA38KPH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_276747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793517">
        <property type="protein sequence ID" value="KAJ3781866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPH4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="63" mass="7222" checksum="9B490E2AA1B15949" modified="2024-01-24" version="1" fragment="single">LHMRSRFSNRSERFADAYRKGCTGSLAAWITKRFQGHRVIPKNMEEILADYADKGPKNIIPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPM8</accession>
    <name>A0AA38KPM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793505">
        <property type="protein sequence ID" value="KAJ3782031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPM8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="979" mass="108870" checksum="F019022C11AE5424" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KPW6</accession>
    <name>A0AA38KPW6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Velvet factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_363953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793478">
        <property type="protein sequence ID" value="KAJ3782406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KPW6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="23"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="45603" checksum="C8DB7EE9013733DC" modified="2024-01-24" version="1">MIQQTNARQRHGPSASDKPEEWGQWSGRKYYSLQIVQHPIRARMCGFGDKDRRPLAPAAVAKMVVRRDDNSLVEVDDIDCSFFVVTVDLWSADGKQEMNLVLHPSSADRYVPPPTPNPTKTRRRGATTSSMGPPTSSSSSSNTTLTSSLPPSQGLEPSFAPPNPPTWGYPSWPQNENSSDMNYRPWNNPMNAEPSTWGPQQAFDFDYSHSQAPTVYSSPPSVPSMRPAPSIAIRSSSYSHPNPNFTPTVPSIPSTPPSYSSIPLPRHTYTRTLVGPLSANATRLLDEHRKPGVFFLFQDLSVRTEGTFRLRMRLMNIGKYPAPEAGATGVMSVDDKDGHGNRPSGVTPVLSQVYSDPFTVYSAKRFPGVPDTTALSIAFGNQGQKLPLRNRHGSSSGKRRRRGDDDEDDSEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ12</accession>
    <name>A0AA38KQ12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_353043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3785984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ12"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="379"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3785984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="518" mass="57289" checksum="03CDFF6B2B67C03A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQY6</accession>
    <name>A0AA38KQY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_374270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="59185" checksum="08FA0CA39559846E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRJ7</accession>
    <name>A0AA38KRJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_271097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRJ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22739" checksum="C4001347273BFE3D" modified="2024-01-24" version="1">MLLKPDPPLEAYDGSVDIRAFIKFVTEGTAYVRDGRVPKNRRVLKLLKYLKGKAYQFYLTTVADSPFDWRLKQFFTELYNYCFPLTYRLDQRRKLKRCFQNDKPVREHLAELNDLFNTIGLMDEREKAHKLWSSLNKKIQKGLWREKLNPELSSYDEIASTAELIEIIENVDPGDEPKKPKMGKSEKPTNASNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSB2</accession>
    <name>A0AA38KSB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_264191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3787785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="170" mass="19855" checksum="067F92616057BE6C" modified="2024-01-24" version="1">MRIEKCYFCSTNVYPGHGSAFVRNDSKVFRFCTSKCHKNFKMKRNPRKVRWTKAFRKAAGKEMTIDATIDFEKRRNVPVRYDRELMQTTIKAMKRVGEIKQKREHAFWKNRQKQRAHRKKAIEAAKASSTKLVKPMAAESSPKREKIKVPAKTRSALVQGEGRSMTMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KSP5</accession>
    <name>A0AA38KSP5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_387037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793326">
        <property type="protein sequence ID" value="KAJ3786006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KSP5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="242"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="534"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="886" mass="98580" checksum="A958222B7AA65D10" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT41</accession>
    <name>A0AA38KT41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_351633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793313">
        <property type="protein sequence ID" value="KAJ3786471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT41"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF83">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="343" mass="37398" checksum="0E994F09BF174A22" modified="2024-01-24" version="1">MNLPDYDPTSNIERFSRELSKARKRIHTVDGRGSQNLSIQGTKLNNGPLSGKKIVIKDNIAVFGKLTADATVVARVLEAGGTITGKAAQPSFSATTGPVHNPFARGYSTGGSFRRLVMRGDQGGSVRIPASWCGLFELKPTFGLVPYTGIAPLEPTIDHTGPMTRSCLDNAISLNSIAGRDNLDDRCAGAPLPSELPDYLRTLFAMKDADMPLKGFKIGMVKEGFEICKNGPLNDLRVGVKVQEAAEKWRELGAVVEDVSIPMHDLGATLWVCISRMGSLPVLWGEMGGRSGYQMTELTKKMYNIRTEEGCDNTPWSPKNMILNGTYLWDKHVCPSQLSLLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTV7</accession>
    <name>A0AA38KTV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_287906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTV7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="295" mass="31547" checksum="380AE810517F1A5B" modified="2024-01-24" version="1">MALALDDPQIASSLLPSTKPTFHSPRSVPSEGYYSPLSNGGSMLTIVDGTFPPGQGEPLNIIISANSDQAVLVDQETDGGLRNYWLSFDYAGECLGQHAGSQQAANLGDGNGVLNETDEIRYDYNDAQLGTCTETIEGGGHFRYWTQNGPKANSGAIFMASSYELPLTDGHDIVSNGYNLGRDWIIGNITQTNIPTLNLTNSSTYSGTTSYGGYTYSTSVKYVSGLLQNTSVGINHNLTVMTSSSNATDGLVAVLEVKITEKPANSADFLIPFLGWQLPPLLLLLVATILPFIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV47</accession>
    <name>A0AA38KV47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_296197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="218"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="496" mass="53375" checksum="C2E0EF317D467359" modified="2024-01-24" version="1">MVYGRDSGFILLSIPDVQIHSRQSSYSQNGTLTIECIYVTPAGQAAIDRDVFLILQINSNEIPLDPRRIITLGIPIEGAPGRIYVLHRTDLESEELELHIPVFDSEDLQRLEDVDTLEGIFTEYADFRESQATSVFASQNIPLKDVSQAPRGHLVLVNEDSGEIIGEVDKKISVHEEPALSHSETGHEHDPVVIEIGQDEEGQAVEVFARTIPADQQDWITNSAKLVSQGISQSTNLLMNVVSSASNYYINHSSPSTSRPASSATLNIPGSGASSKSLSSSSKAIAFISSSRTQTGLTHAHALTAQAVKVSGKTLSLIDDMIGKIIGSKSKPSTAVPSSSSIHTGMPPPPPYSTIPSTNAKPLLPPRNTSEHLKLPGPEKPPLPPRHATVTAPPLPPRTLTKKVKLVLSADLILSTIDESLKQLIDVGGRSATRVVQHRYGSDAAQSTALMAGTARNVALVYIDMQGIGRKALIKRVGKQYVKSRLANSKQKADQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KW15</accession>
    <name>A0AA38KW15_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794487">
        <property type="protein sequence ID" value="KAJ3779633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KW15"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="159" mass="18296" checksum="EF1634E42465180C" modified="2024-01-24" version="1">MGMNQIPLPPSHTMVVRSVRARIYRANQILGEPTQVFYREDPRQVQRGRYLLVADQLSDPRMQPCVHDSIVTTCHRGKKYVFRIFYKRHKCLPVNQALQQLAGVEMEGDVLVVAVGKKVGIRNIHSNLEMRAAERAVQKFAQKLAPFRNRRTFPSSIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWT8</accession>
    <name>A0AA38KWT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_374837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793312">
        <property type="protein sequence ID" value="KAJ3786522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWT8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="287" mass="31648" checksum="D880183D88966E56" modified="2024-01-24" version="1">MSYSAGVDLDWCLTCNQHLNVPNTSYCSPQCEQTSSKPLLNLSSNVNEWTHSEDGENDAVIYHVVHDTSSPKGIAAWAANVPTGAPPNDLLPFPSHTSSQPKLLRPQCVRLAPPALSISESTSASIPLATPSSKDVTMLSSLANHIRSFVSSSSVGFPVNKLPLRTKSHLPNSIAHLRRRESSFCSDSFEEDDNDLSPSLSPFEETEDFWWVTDSDSSSAVSSVVPKKSEAQRIAPSERQKHRLDCEMFFQPKILPIPIELSSKMQVAGLQDEEIFEPRGRQVCQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXP8</accession>
    <name>A0AA38KXP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_426505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXP8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3787977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="342" mass="38053" checksum="C9BA08D6F75E28BA" modified="2024-01-24" version="1">MSLLLSYLDSPRPNQNFVLLQSSVSQSSLPLLRHIIAHNESVEKHLFCFLHPSSSLVKNTQSNVQIHEYLDRIPGYNDPWLDPCLEVSKIIENVPSSHPIEVIIDSADTLLTDNGSISDAYKFLRSLMTLISARSKQTKLILHLTTPNKLLPLLLSTAFSPTLIQLIAHPPVLFTHLATEYMTPPPPLSSDAKFWGIFIPISERARDTEALIFGQEGEGSGGQEEMVVEVLVRGGSDASGRRRAVERFLEGWDLENNLPLDLSKMKSLTSIWRRKIVAQEAAPDPTQNVSFNLHLTPSQQESRARVPLPYAHEAQPAPGAILYDPDSADDIDDDDPDEDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYE8</accession>
    <name>A0AA38KYE8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_384463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYE8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041308316" evidence="1">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="178" mass="16350" checksum="6839FCDBCA28D7C9" modified="2024-01-24" version="1">MKFTSPILAGSLLLLSPAAVLAQDSSSTIDTTAAESSALSAASSVISADGGSVTVIAGQTITIPSGISIPAIPTAILSDTSLIASLASSLTATLTGSLASEASSILSEITGGGASGASSAATATGSSATGSSATVSGSSAASASTTGTSGNGALSLGGGVKSLIASVGAGLLAGMWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYM0</accession>
    <name>A0AA38KYM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_44639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793403">
        <property type="protein sequence ID" value="KAJ3783803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYM0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="384" mass="39657" checksum="C349BB77F9AD248C" modified="2024-01-24" version="1">MVGSAAAHRKLRKVFVRNELLKERQFGIGIGTGDLNPADIIGQIFTSATDENHHSSTSSSAVPSSSIIPNTSILPATSATLSSQVTSTFISSTTPVATVSSPTSTFQFISSTASQTTIPSTSASSASPTADSSSSSSTTSSGNIVGIVAAVIIAILALGVFGFFILRRRRTNRNAKLIHQVDPFKVGLPEKDLPPPPVPEQRMTFGTFYGRPGPGDDPFGKDQTNPSTAYIPSATYLNGNSASMNSPLYGAATVGDEKFARATSGRSLTSPFSDSTSSILSPIASPRIPSPAQSPFADPVDPSVMIQVPPAAGVKYTPSYVPIKDGSSGVPASVYSPVVRSSFGSPTVNTHKATGGKGSSGSVSGQAQTRPATMYNEEDVYAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYM1</accession>
    <name>A0AA38KYM1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear condensing complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_42441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYM1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="593"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="958"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3783818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1112" mass="125096" checksum="43A2BDE4F4A96648" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0A5</accession>
    <name>A0AA38L0A5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0A5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="362" mass="40303" checksum="4397A91F95887F83" modified="2024-01-24" version="1">MFNLNIDKETYGALLKSYQEQRPLECLDHDLVQVPQSKNRPVKVLDPVATSKSSAHTSKGSTSHQQTSTQKKTPSAPESVSTQGPKKSNSLQSTKKPKFFTSASGQKQLIADTNATKQNSYSDSDEFVPETEDFDDSEEDLRSILRRSKSKSQPSTPRKSFELDNITKTPRTSVKITHTSSSGSEKSPNESRAKAASNSNSERLMNSKNVTALQREPPARLSLPQEMDVDKFVKLHIIKNKVLSLMQPASSSMQAKLQEISFDIEDIAASYLPDVNHSVGDAQCDQAVRSSGVSKRLRFNSADQAQEEDELFTPRKKQKVRDEGDEGDDVDDNDDKEYDKASTLKTPAIMKRVCLRRTRVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0U7</accession>
    <name>A0AA38L0U7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_85488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0U7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041303935" evidence="3">
        <location>
            <begin position="18"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3788903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="458" mass="48646" checksum="44AA471D297FDD1A" modified="2024-01-24" version="1">MWILIFPLLSIFLRVNAIVGQVACSGTGLDWYMNMVGETPCTTYERLRQICNPSFQVGTLNTNTPPDACNEQVADCCCNSVAFTLSMLCLNCQQNIGTGSGYDAGKGAYQSYLQGSRSAGSWCSPVTNQSLPHNIDNAVCDNNIKIIDDIRTGLFWADGSWFYMWSYEAISKDVNANGGNAFTHCASIASTSTSTSTSSTSISSPTTSITTVAGPISGQTGTVTAQGTGSSKGLPSPSPNSNSFDGASTSIGPNNNFSSASVTVILGITSTVYPSSSTSSSTSSSGNSNSTTPNQTLLASSPMSKGLIGGIVGAVTGGICALLTLWFCCRLRKCHDVGTKSRLRMIVEPFEDRQRSGYTLTGSISESSTPLVLRPQKLQLEDLRNSTRTRSQATSVHYDASTEIDGQRDSQIHPDSVLNSWQMPLSPLRHTDAGPVQVQIAERRMSESLPPAYGEQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1F8</accession>
    <name>A0AA38L1F8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794807">
        <property type="protein sequence ID" value="KAJ3779482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1F8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="104" mass="12142" checksum="755072F3E278FE9D" modified="2024-01-24" version="1">MFHFELRHIPGKKHGSDGLSRRDWQPGDEIHFNPEEEYQEEPPAFTVTFENGVDTTIPFEEFKDKIDTRTGFSQEIPKSVQDLLPIVQKASEGEQQFRTSKDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1M9</accession>
    <name>A0AA38L1M9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_250590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793928">
        <property type="protein sequence ID" value="KAJ3780082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1M9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21357" checksum="70EFE29AA01F4613" modified="2024-01-24" version="1" fragment="single">LYTAAKYATCPGVDQDALTVIPTLKIIDTNNTVTRTAETNEDKAQLLAETFFPAPPPNYNLERNPCRNQLPNPPKITQERIIETYQKLKPYKAPGPDGIPNVILKKYAGMLAPYMSEIYNAIGDLKIYPRDWLTSTTIVLRKPAKKSYSLPKSYRPIALINTLAKGFTSIVAQDISYLADKHNLLPDTQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1N0</accession>
    <name>A0AA38L1N0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_381187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793919">
        <property type="protein sequence ID" value="KAJ3780097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1N0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104:SF2">
        <property type="entry name" value="CXC3 LIKE CYSTEINE CLUSTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104">
        <property type="entry name" value="SI:DKEY-29D5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="192"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="932"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1109" mass="126582" checksum="D65357B5C8D1AF36" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1R1</accession>
    <name>A0AA38L1R1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793776">
        <property type="protein sequence ID" value="KAJ3780352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1R1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="181" mass="20073" checksum="9B2F89CFCB067547" modified="2024-01-24" version="1">MSTTSSPTRPAPSFTPVLNDEDTELQAFLAAAKRKVQEKWEKLRVAKMSGVEEKVGEDGGNTVEAKGNAKEDVVEVEKEVVPKIEAKPRKVVMRMVAGLPRNREVIPKRRNVADLEVAESSRKKQKVVRSPVVVDTDSDSIPVPFPRPCERCVRGDQVPHREAELFFPSESEENAGSIPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L207</accession>
    <name>A0AA38L207_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_413024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793596">
        <property type="protein sequence ID" value="KAJ3781147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L207"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3781147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="403" mass="44132" checksum="93EF4B188D0ADA23" modified="2024-01-24" version="1" fragment="single">MSSPSEPLGIPRHGSQSRSATPAGTPDLRALKAQVISGTPPLVGPSRTESPLDLPVDLDDLPDEEKAKILRRHLVSREERERERIDTQEGTPSFTPESPSQTRRSSGSGRIAREDSEPFPVPYAAPGADVTHDIYKWHLNAQRQARRVRSASFSAATRPAPDPAFEHIHESGGFRRDYVLLRAGNEEGNEETRVFVNNFIDLLFLFGHFAGEDLEEEDEDNKDKDDLEYAGASTSVTPAPGFGALSATESSPLLGNKPRMSRYRYRSRRRAASMSTGNATVGQAVLMLLKGFVGTGVLFLGKAFGDIGGALYGPWMRHLILNSIVLSQIGFVRAYMIFVSENLQAFASSVTNCVQYVPVNTTALVADAYILVGLVYIFSSEVGLVIDRGARDVQMFNPKNFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L225</accession>
    <name>A0AA38L225_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793578">
        <property type="protein sequence ID" value="KAJ3781282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L225"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="62" mass="6879" checksum="E7D6529636948107" modified="2024-01-24" version="1" fragment="single">TQTFPSFSGHVSPHLCFYVDFSLPCFFLGLYVVGSFWASLLIYSVTVATVLMFLVVLVGIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L546</accession>
    <name>A0AA38L546_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_418696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793308">
        <property type="protein sequence ID" value="KAJ3786682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L546"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="523" mass="57818" checksum="6647304A87467490" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBA8</accession>
    <name>A0AA38NBA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_238611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793733">
        <property type="protein sequence ID" value="KAJ3780466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBA8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="181" mass="21290" checksum="55BB7977739135A8" modified="2024-01-24" version="1" fragment="single">QFLATVNTMPEWARVKTERITKDFLWNGNKRGLIDWKWVTAPKDEGGLNMPSINTRCEAIEIMWGKKWLAPQQKRPTWGFVLDEIINMNIPKSPIIDREARVNWVLQNWHESDAKWAQIPRKAKSMINVLRKYNVGVEALKISKETKNKMPIWHHIDASSNHLWSKKSARCLRREHQVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBY7</accession>
    <name>A0AA38NBY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_429528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793480">
        <property type="protein sequence ID" value="KAJ3782371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBY7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="185"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="330" mass="36547" checksum="5421DAC3F8CC5725" modified="2024-01-24" version="1">MMLEFLAMLTTLEDSPGIDMSAIFAPFFWGFFVSIFLGGITIVQAYMYFPHPTDTRSVQVLAASMLILDLISSALVAQSLYYYLIPHFGSTEPLRTITPELSAECLISGILTFTSQMYFVYQIHSVKHNGILAWTILVVLTLFAIITFVGGIGCVATMYVFAYGVLADRSKDFAIFFGVAKGFGAVTDIMATIAMCTYLSNAKTGFSTHTDSLIKGLIQYIIERGAVVTLIQTLLLITFFAAPNNLYWLAFHINVTKLYANTFFCMLNARKSLWKKHAPNNSSMLSSNGIDLRTTRFEGSGKSYALSSLQREVQEPEMPTITKSVVISEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC22</accession>
    <name>A0AA38NC22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_73921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793458">
        <property type="protein sequence ID" value="KAJ3782716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC22"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="579"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1146" mass="121074" checksum="D0F942EC7212F338" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCD4</accession>
    <name>A0AA38NCD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_316343</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793408">
        <property type="protein sequence ID" value="KAJ3783691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="103"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="196"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3783691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="296" mass="32266" checksum="861AB4BD2F7764D1" modified="2024-01-24" version="1">MSDQPKKPLPFVANFAAGAIAGISEILTFYPLDVVKTRMQLSTEKSQGFVGTFKNIIKEEGAGRLYRGLVPPLLLEAPKRAVKFAANDFWGKTYLGLSGEKKMNQQLSVLTGCSAGATESFVVVPFELVKIRLQDKNSTYAGPIDVVKQIIKKEGVLGMYNGMESTFWRHLWWNGGYFGCIFQVRALLPEAKTQQGTLANNFISGAVGGLVGTMLNTPFDVVKSRIQSAPKLPGVAPKYSWTYPSLAVIAREEGIGALYKGFIPKVLRLAPGGGVLLLVVEFTLDIFRQALGPPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH68</accession>
    <name>A0AA38NH68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_230452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794214">
        <property type="protein sequence ID" value="KAJ3779792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3779792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="76" mass="8029" checksum="BA99E87B146F067F" modified="2024-01-24" version="1" fragment="single">IRESSSLTAHPVGTAAMSAKGCGLWSCESRFNIEGVDGLRVLDASVFPFITSAHTQATTYVIAERGAALIKSVFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHS4</accession>
    <name>A0AA38NHS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_390423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793532">
        <property type="protein sequence ID" value="KAJ3781697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NHS4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="54"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1144" mass="128627" checksum="7CBCC120BA472B8B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI90</accession>
    <name>A0AA38NI90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI90"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="261" mass="28862" checksum="EDC65B32634FF931" modified="2024-01-24" version="1">MSPQLTFTAELEPYLDLPPPSGLPGSRSHYTNPFGPIARPGITSTSEPLVSSKSDPSLIITHGEVDDPVFAPDTCGLQPDSIDAPRLDYAKGAGDMDYYKTTPHYISSIWHYLTPDDDLEADKRRTDYFIPEPDNSTQLESMNPCSLAIYSAFPWNTTTPSLVSFDSLRASGVIPRTNVPSQTIDIDMYSRLPLSASENSSSEPTERQTACHCVQCEPPRDRRGFSLRIHASDSSSSLSPPETPLLTPYSEYDETFYRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIG2</accession>
    <name>A0AA38NIG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794408">
        <property type="protein sequence ID" value="KAJ3779673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIG2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="670" mass="73138" checksum="775AEBBA6BC22CDB" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIG6</accession>
    <name>A0AA38NIG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_396115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793403">
        <property type="protein sequence ID" value="KAJ3783812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIG6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="13">
        <location>
            <begin position="302"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3783812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="527" mass="60813" checksum="900D17368BA008BA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NIR9</accession>
    <name>A0AA38NIR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">beta-glucosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_391315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 7"/>
    <dbReference type="EMBL" id="MU793823">
        <property type="protein sequence ID" value="KAJ3780258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NIR9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="8">
        <location>
            <begin position="401"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="850" mass="92636" checksum="65EB67D7AC69FC98" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ97</accession>
    <name>A0AA38NJ97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_279362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793733">
        <property type="protein sequence ID" value="KAJ3780454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ97"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="79" mass="8713" checksum="3F5C9D7F78B4D760" modified="2024-01-24" version="1" fragment="single">PQWIVATRLLYHLQYPVPIQVVCKGFTPAHIMFTIREQAAKAFPPKQPSPPDLVHEQSSISTQVTCAGPTSSFLARVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJE3</accession>
    <name>A0AA38NJE3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_278990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793679">
        <property type="protein sequence ID" value="KAJ3780649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJE3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="808" mass="92152" checksum="05A96DBC86EB9C47" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJH3</accession>
    <name>A0AA38NJH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_312515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="381" mass="44784" checksum="1A6AB2A078E3174F" modified="2024-01-24" version="1">MTWTRQLRYIFMASLLMVAYHYLSSYHAPTGLHWDKISGKSSSSNPPLSSLQQCQSSDYPNTSYELANATFVMLIRNSDLDGTISSIRALEDRFNSKFGYPYVLLNNEPFTDEFKRRVSVLIRSEVQFGLIPKEHWSQPDWIDEENAAKARKQMVATNVKYGGSVSYRNMCRFNSGFFYRHELLQKYKWYWRVEPNVKFYCDINDDPFRYMEENQKVYGFTITVYEISATIRSLWSTVTDFIENHPEYIATDNAMGFISDNNGKTYNRCHFWSNFEIADMDFWRGEAYTAFFEHLDSKGGFYYERWGDAPVHSIAAALFLRRDQVHFFEEIGYQHDDWGHCPLPDDIWEKGRCSCSQKGSFGSDYDPSSCKPRWDKFMNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJK8</accession>
    <name>A0AA38NJK8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_390456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793535">
        <property type="protein sequence ID" value="KAJ3781653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJK8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="160"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3781653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="646" mass="69849" checksum="3617AC90FD63812A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJQ4</accession>
    <name>A0AA38NJQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_181631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="395" mass="43817" checksum="9BF9A3E07A73F8C3" modified="2024-01-24" version="1">MSDQITELYNEALRPAITALTFEVLFYGFYISLSATYFSLLARQRNEKKFKHLFYPVSTFVLFILSTAGIILSTFDVANLIKLLLVSMAEMDPTAREETFVGTRTAIGIVYALANLVGDIILIYRCYFVWNGRWLAIVVPAFLSALNTAMVFASIANIQLGSSEEFATGGNSSQVTTGDNLQYAFLAMNTFNNVLLTGLIAGRLWYLNRAATKLFGISPSPDKRYRTIVSMFLESGSLYPIALVICLIIQLKGSSATMDPVLLQIVGIAPMLILVRTTLGISIESAPRREDVDTELEHTTLRINTYPSDQKFTPPFAFTPGTNFSPVTGTDSMITSSDYQPRAEFHPLPYDSSGVRRSMSSNYHPQPSSDNLEHNSDIGPSTPSERLQPLRWMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJU2</accession>
    <name>A0AA38NJU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_352511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJU2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041385847" description="Cupredoxin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="20991" checksum="F37A44FACEE45BCE" modified="2024-01-24" version="1">MRFFAVVAALVSAVAADTFTVIVGGNSTITYNPTSINATNGDVIQFQFVSKNHTVTQSTFAAPCTAMAGGVDSGFQDVATNASTFPVWSFTLTNTSAPLWFFCAQTGHCANDGMVFAVNPTAAKSFEAFQTAALATGTGTNSTTTNSTTSATSSGASTSSTADSTVATASAAVASQSASGAVATANGASTLASDTIVGLVTVFGVGVGLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKF7</accession>
    <name>A0AA38NKF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_152575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKF7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="420" mass="47484" checksum="A8EEFE9CE14476DE" modified="2024-01-24" version="1">MDEGESMTELITDGVHSIPRLAQVEVPLIDNEAGITIYGHDTLFHARLRPVFCQGGWTLGGLGDDASRVIVRRLAKESSDEDVHQEIRQSLSYYYPYVMQLFGASKIGSPNKFLIYSNPNVTTYINFKGTRLGEDYRSYDAQYDESFNSAWRYLKNQVPVDGFTLDVIFSETRTVNANGGSALIVVPALPSSPVDRAKLITKVLEEFRYKIKRRLEVAKLPKFTRCLECLPSTSGWNSGLINSVLRCLNNVEPHLEWGQFLVQSRIGQGQYAEGPSDEDHVQDYDQARRNKEEFDFEFEKADKLIKLLRETTESELNKAMNEVILRSNLASDGICSWCAKKWDRKQLSPTIEDSSAFITIVEEDTPINSQREGLSSVGRHLAELVYGGGYLMRIIILAVCILLAGVFTLWKKRAMAENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLH1</accession>
    <name>A0AA38NLH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793385">
        <property type="protein sequence ID" value="KAJ3784219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="124" mass="14981" checksum="870324CB5A5EF545" modified="2024-01-24" version="1">MPRKHTKSAIIKSERTEEEKATAKAKARMIVNRRYRRKLLRKVPDYDRERKARSRADFTDEERAAQKDKKKEENAMGYLRHRENILAKQMQKRAGAYIEKHGESKFIDSYPHRDVKFRKYLQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM37</accession>
    <name>A0AA38NM37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_422385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793338">
        <property type="protein sequence ID" value="KAJ3785554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM37"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="39085" checksum="D767F6004E8A82DA" modified="2024-01-24" version="1">MTVPHPSITNSSPTRRKCIGLKFRTFVVDSTLRRVNVAVLCENSAVFRRIVSENADPDTPIVLHGSTTRQFGNLLWGLEVNSMPQPRDEGDLERILDVEELSRHYSMYHLQVRAESALLAAIAEGTNPAILACNTHALVRMLRITMRVHNETLFSFLMQLWTWRLHSRELDHALAIRMAHPSCWDYDPQPFLKLLGHAFYAAMVVMEPKLSKGQHIDLDSQLTRAEIVHVRCGYHSLRSWWDQIASKAPAYMHCPRCMNPERCSYVWRIRIQWLAENDKIPFPKVDGIRRLQELHRLLAADSFLIKNMPETCRHSALQELLKRKEHLLKTVHHHFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMC3</accession>
    <name>A0AA38NMC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_177304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793321">
        <property type="protein sequence ID" value="KAJ3786154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMC3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="237" mass="26462" checksum="10D30C9B1866D800" modified="2024-01-24" version="1">MEYSSVFLKARAIIFSLISLISFIWVVVICVDLFIQWGVLSISERAFLVVMLLSNTLTLIMLLVLLILPFRPWLDGARLMLLLVMHIGIASGFALWNAKFTCPTKTVDEEGVCRLLNMYILIANWIIPATLLVYALGLAVMLYKRRKLKAVLPDLESSRSRQPESRQFILPMMVPADIRFPSVSTTPHTSVISQQLRESVWGAGASSSPPQSIVEGKRGSSSGRSRLSKPLPGSMYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP55</accession>
    <name>A0AA38NP55_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lariat debranching enzyme, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_361713</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793435">
        <property type="protein sequence ID" value="KAJ3783125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="357"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3783125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="548" mass="60209" checksum="BCA63F1D1C96AAE0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPA9</accession>
    <name>A0AA38NPA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_388685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPA9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="241" mass="25623" checksum="3CE3488C59A1AABB" modified="2024-01-24" version="1">MTTYSAFFSSGLLAAPHMYSSHSVYDNRIPSHGDPSPSLLSVSDVIDDTSDLELDRSTTPTPTNVDGQATSTHQAQHCIRRRRSSLTVGTSPMNIIKSPSRAAGTALQLQRHLLTSPGRSRSGSTSSVVSIGEEVNSNIASESTSLYRRMRSGSVGSVLKSRRGARRGAPGPKFPPPSAPLPALPSIPGTPSRSKAFSLAVPSIATQALARKLADNPSPSSRQPLGEIQLCGYRNDQEMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPW7</accession>
    <name>A0AA38NPW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_243798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPW7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="116" mass="13473" checksum="D0B67E63B1966E14" modified="2024-01-24" version="1" fragment="single">VRRRYDIPESDPVDLTAIPDTPDGSRPDAKLATILHLAIAGSSRQKLTLREIFLAIKDRFAWYKNSEDKRWQGSIRHMLSMKAEFVQVPRPLMEPGQGHYWTLNMNLTGDKRVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPZ2</accession>
    <name>A0AA38NPZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_348794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="3">
        <location>
            <begin position="162"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="298" mass="32577" checksum="4A0152774F886605" modified="2024-01-24" version="1">MAYRDQYTGHQEFNPYSNPQPHASYEEPHAAAYDNYGPGYQDTAYSAAGPTKTRDADEISSGFDRGEFGSPRGEKAQNFSQYRREFRNENLWIKGGRVSCIGRFFCCTLMIAVFLIVSIVLALALWIRPPSIIIGSAGLTSAGTSGIQFQTSGIVVPLEVNISVNNPDYFSVDLKQVTLDLTYPLDGNNTAIGNGSTSDITFHSHSNTTFTFPFEINYQFSTDPNYAILLDMASKCGILGGSQSDITIDYSIKVDLKVILIPVSPTISNSFSISCPFDESELEDFIKSLGLSSIAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ58</accession>
    <name>A0AA38NQ58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_286327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ58"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="930" mass="101273" checksum="DB912ED856E88A8D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQJ2</accession>
    <name>A0AA38NQJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_284690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041402499" description="Glycosyltransferase family 2 protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55415" checksum="799C3CF100463E8F" modified="2024-01-24" version="1">MWIARSFFIVLWVTINALLIKKIPPDACLSSSASHISQCSAYLSKLTFSPSKQVADTTAVVLNWSRFPNVIQIVSLLCIPELENTIATIHVWNNSPNKISKEDFAKCPADRLKITNSPSNLYFRARFYACAEATTPFCFVQDDDYLVLPEIIQTLRLRVSKDSASTIYLLPPHEALSSVLKRMRVGSKIHTSFAWLGHGAIMRQTQTRDFLALMQHLNASDDEMKMADNYYAILANVFPEVWLDQGIELGGGQAFTQGVEGKERNNRHIVQAAKYLDQIMNCVHYPCIGHDIPFVSLEDQTLSLVHRAPCVGRPCLLETTISLLPSTQYDLKSATHILENERLNRDLFKSGEIEDYLWHPPSHAVDGNLETGFCIPKGVRKGDTVGIDILGPRAKDGLAEVAFLVDRNGRSILLAAATLQFRVNEWINSSVPFTCVATKQDLHECSSLTPSFHFSAFQILFVRDVERRACFREIWIRERSTSSSPDRSYLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRC2</accession>
    <name>A0AA38NRC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_39029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793258">
        <property type="protein sequence ID" value="KAJ3789671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRC2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="414" mass="45523" checksum="875B4ADEF6AB65B7" modified="2024-01-24" version="1">MNSKIVILGAGCFGTSTAYHLLQRGFQDVTIIERSDEFPAKDASSNDINRIVRTSYPDPFYAKLAKEAIHSWKEDVDIWGDSYHESGVLVLGASDYAHNAYLNDVQQGLRIEQFEQSSTIRASFPPISLSNDTRGYLNHDGGWVDAGKATLLLTKKVISLGGKLILGKRATKLIRKEGITQAVGCDDGTIVETSLVVIAAGPWTPSIFPELGYNDNSLATGQGLAMVQLSEEEAMIYRDVPVILNFSTGFYCFPPSKDNIVKMAIHAPGFTHTVGNISIPRTVISHPDDGLFIPKTYAQRLRDEFAAVYPELAKKGFSNTRLCWYNDSPDSDWIIGRHPTDPSIMFATGGSGHAFKFLPVIGRIVADAIQGTLDPVLEQKFAFNRKITHVDDSRDGSGMFRKELDVDELCGPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRE4</accession>
    <name>A0AA38NRE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_342709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRE4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="520"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="577"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="613"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="659"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="695"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="731"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="767"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="803"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3789725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="995" mass="108318" checksum="9E0CE386F30F331B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRR3</accession>
    <name>A0AA38NRR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_283129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRR3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="370"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="432"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="478"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="571" mass="62946" checksum="086386EBE13559FA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRU1</accession>
    <name>A0AA38NRU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_10015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="105274" checksum="F7C244186E2B6923" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRV3</accession>
    <name>A0AA38NRV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_231920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRV3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="67" mass="7577" checksum="4EA3BC29D798AE6A" modified="2024-01-24" version="1" fragment="single">QIRRLCGFFATLTSKQHLYPIIHSSTRLPFPSAKHKTRLLALNPKVRIVVSVNHINAKSSAELSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS84</accession>
    <name>A0AA38NS84_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_189895</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NS84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041265025" description="alpha-1,2-Mannosidase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3790194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="543" mass="59791" checksum="69FE4DE7C7D9547E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSP3</accession>
    <name>A0AA38NSP3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_340790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSP3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="216"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="327"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="442"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3790431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="577" mass="63180" checksum="00A283D087EF5321" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT55</accession>
    <name>A0AA38NT55_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Surface antigen-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_339943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="181"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3790667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="497" mass="54148" checksum="99E60D31B70DF7F6" modified="2024-01-24" version="1">MTSGGDDKPLWTLKPPLQNSSSPLDQEPVEVQKLRRWQEERVAKKLRSDYESATLHLADLINASLLAPLRIASVRVEGAHKTRPSFLGFLINPIISPNSEEHPQDVQTVLHTTRRISDLLQRADIFHAVSARIERSKDELFPADAVDLVFKAREKGRFYLKTSTELGNNEGSASAIGRIRNVFGGAETFEASMSLGTTTRKSFNALFSLPITPDLSTYAEIGAFGLSRDYSTFASCSESLRGVKALVRHGEVSTGSHELAYQAVLRNIGSLLPTASISIRECAGQTSKSSLSYTYTFDNRDDRITGTRGFHTKFFQELAGLGLGGDASYFKAETENHVSRSVLPGVTVALSACSGVLWGLLPAPSLFPDRFQLGGPLSVRSMRFAGLGPRDGSDSLGGELYWSAGLSVISDIPRKGHWPLKTHVFLNAGRLDEIDKSRTFAENIQNTISKPSISAGVGLVYKFDPVRMEVNFGLPLVASKSDGTRKGIQVGIGLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTC5</accession>
    <name>A0AA38NTC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxyneurosporene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_424939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTC5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041408359" description="Hydroxyneurosporene synthase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="2">
        <location>
            <begin position="86"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="3">
        <location>
            <begin position="238"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="40826" checksum="6F106ABA222B7957" modified="2024-01-24" version="1">MFLLRNTLSLLAVTSLTISTQLVAYAASFDGQYIQPNLTNTAVEWWWGSAVGTPESPGTPGPVLQFLFYQGYSVLADFNHSALPEYYITINGFFPNGTDFSLTVPATSGDISEGTGNAVTGTWGTVGAFRTSSDLKTMTVTFNASDAPYGISGSMKFTSNRENHYGCNVTDSPYFETSKPSQSLNETEQVFFNQLGWAVTIPGGTVDVDVTINGTQLQFTGNGYHDQNWMPFALNEFISSWYFGFAEIGPYTLSYVSAAPLNSSIVFNTGYLSTNQAVLQNQCSITGSKTTDISIIRPTGEMAGAEGTVAPSGWTLSYVLDDGTEYEFKMVPTGVNPNMAVYQRWTGLISGGKKGEESYEGVATFEWLNPGLNVYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTR6</accession>
    <name>A0AA38NTR6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_339028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTR6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="81" mass="9411" checksum="C469055EF8C08181" modified="2024-01-24" version="1">MPPSPYSQLQKKLFKLINQADFDFFLPKLSRTTWDTIINDSDERERLEFVGDFYMSAAVGESLCRYLPNGSPHQYTVRVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTR8</accession>
    <name>A0AA38NTR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_257464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DExH box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3791002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTR8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="279"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="538"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1144"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3791002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1164" mass="130037" checksum="A05F475EF9D3ED30" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTX2</accession>
    <name>A0AA38NTX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_281071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTX2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3791086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="270" mass="29158" checksum="BA21D6571A701B45" modified="2024-01-24" version="1">MSTFHQLMTLDQSSTHYTQPPIPTGGPATEPDGPRSFAFVPALGILVPHPPPPLVIQAQRHDAPGQDFINDIADTAPGIEGNPGTGAGANHYPSSAGVPRLPPILQVEKQQVTTSATQLASASRRRNEANFACPVPGCGSTFTRRFNLRGHLRSHTEERPFVCEWPGCNKGFARQHDCKRHQALHNNKPQSNICQGCKKTFSRLDALNRHLRSDGGAECRAKQAMKLAANPDQSGSSSLQAPPQVPPAILHLQTPPQVPLQVPPKLQVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU90</accession>
    <name>A0AA38NU90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_382816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU90"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3791141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="30160" checksum="9495ABA1A73383D7" modified="2024-01-24" version="1">MPPSAMAEKRKLIHRITKTIMKSHRMRMPNHYDLPIRLRPWFIFFTVVIMLCLAILGFTNVSHYLPLNDKFLHFICFLIATTVFYFVFDVDEEYRRIWFWRHSGLIITGFLCVFCGGILSEFVQSMLPYKEFQMGDIIANLLGSSIGLYVAYYMERYYRHRREISRLYRPLDMDTLSDDEDDDAAGAQLLPTHNSQQRKGPNTNKSVRLTDVWDEREELFGVGEDSDADDDDEGDDLNKHASTHHHHSLPKITVTASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZ02</accession>
    <name>A0AA38TZ02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_342336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZ02"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="154"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3789779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="507" mass="56274" checksum="1E5836C7199182F8" modified="2024-01-24" version="1">MATQTTHSDGIPIIPESSANSGPRTTMNGNLKIKALPAEFYDRFLSDRAKQLQPSPIRGLYPLEKKPGVISLLAGKPEPSTFPFTSLTFTAKDPLKENSESTITISQDQLSPGLQYSDTAGIPDLLKWITTLQEIAHGRKHGMHASGEGEEGWRLSIGSGSQDLISKSATALINPGDSVLVESPVYAGVIPIFKHMDCKQIEVPTDAHGIRASSLKEILENWPEGEKKPKLLYTVPYGCNPTGMTASLERRKEVLKLARQYNFIILEDDPYYYLYYGKSARPTSYFALEVTEPCGEEAGEPYCEVGRVLRFDSLSKILSAGLRIGFATGPEAILRKVDMLTANANLQVSSLTQLIAFRLLDSWGYDKFFVHTKNVSAFYAQKRDIFERELKKWLGGGVPEEGETDEGRLADWVSPEAGMFFWFKLLVDTPDNSSSQDSDEQDSRTLIETHAYANGVLALPGTVFLPNGSKTPYVRASFSLLTEEQVVEAMKRLRKTVLEVRSERDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZ84</accession>
    <name>A0AA38TZ84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_392333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3789970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZ84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="385" mass="43324" checksum="69440AF915ED0A7C" modified="2024-01-24" version="1">MNTVRWEIFALLRDYASLVPARFIQIPPNISFAEMNRCLVELIALNPHFQLYAPSNQYQRSFWKTMVRQLEDLLNRSGEEDEEIDSRILDHYLSTLPTSGPTPGSSAPSLRGQICDRGLPLGEPPSKSFVTYFWKPKLNQVQEHSHQDMVNLTHYRSSTLEESRTTIEGGTTGLRTWFASHMLARYLIQNPSIVEGKCVLELGSGIGYLGIIVASLQQLSPKVSSSLWLTDVNEEVLSQCRRNIQLPCNISSTHKSVEFRVLDWEEVLRSNVKPLENLLQNQINPDIIIGADIVFDPALVPPLVAVIALVLQLGYKSGIQRSAIIALTVRKAETFQSFLNHAREKGLFFEDIPLPEAKGFEFVDAVETGASADNVRVLRITLHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZL6</accession>
    <name>A0AA38TZL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_259226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZL6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="55"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="522" mass="57826" checksum="9B7DD594367667CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0R0</accession>
    <name>A0AA38U0R0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase 1 beta subcomplex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_257766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0R0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3790782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="64" mass="7366" checksum="3FF1F8A743705FF1" modified="2024-01-24" version="1">MSNLPLYRDPWAKLDAWRKSPVFQKTTVLRNMFPGFGIAVVAFTAYVIADNVYSSSHKKVEEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1K5</accession>
    <name>A0AA38U1K5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_170522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1K5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041225542" description="Autophagy-related protein 17" evidence="2">
        <location>
            <begin position="26"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28429" checksum="33F3BC9AFC958F01" modified="2024-01-24" version="1">MLGILRWKILSSILADVSLSDPALANFLTHLQLAIASPDLSFKLSNDPALETQLLQEIESTLSSISAFLGDGTETNLSERLYEALEEIASLESELSSSWSSAIDLITHINQLHTTLQTELLDAISTIPPSLHNKHKAHNALSAAIIEASLVKLSLMKAQLHQQIYGFSSDTQPEATMTNALSIAYHKLKDEAEDLMEAERDLDGRIDEYERLMQLVEGDFREGFGQIVEDYIRVEKETEECRRDLRRLGWTGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1P2</accession>
    <name>A0AA38U1P2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_2330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1P2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041313787" description="Pali-domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3791290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24108" checksum="B79B3C7EC106495C" modified="2024-01-24" version="1">MLKFLLFSLLCTIICLCGTHAAYISIHDQKQSWAGLQEGLMVTPALDELDTQYLCDVMIANDAFQISVHATSSDNWLTTYLDGTELPKEYIAVIDQHLRTNLGQTTSPTSTSDHDHSYSLSSSSSPGTSSSISCKRLDISGSALRQRIGFMHIIDLLSIIGVGFLAATASGIAALLRRHDHQRPSTEIPRFLQLNHLHERPHSDETDYAFDYIKSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U1S6</accession>
    <name>A0AA38U1S6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_280740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U1S6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3791219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="94" mass="11173" checksum="E88E31D007F9FE16" modified="2024-01-24" version="1">MSTLRRSGLQKDVLSLYRRALRMVKTKPPSTQDKFTLYVRYTFRTSASSVSPRDVSAIEHLMRKGKRQLETYENPSIKDCWVSEEMRNWEKNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U5C4</accession>
    <name>A0AA38U5C4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_54242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U5C4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3789375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="868" mass="95349" checksum="34482D7B9967B343" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7R3</accession>
    <name>A0AA38K7R3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793681">
        <property type="protein sequence ID" value="KAJ3780639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7R3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="52"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="36262" checksum="95CC4E54F57317F0" modified="2024-01-24" version="1" fragment="single">GPRRIKESLGHKGIHISCDKITQVMQDYAPEGFHQRAPGTKVIHRTPLISNGPNDEWSMDGHDKLAKAGFKIYGIQDKYSGKYLHYVVLPSNRYAAVIGVVLLKCIKKYGGAHRICSTDRGSEVRDAFSIHSILRQHFAPDLVEELIPSWNFLVSYRNITVERSWRPVFEKWGVNILTFYNTGLYSGDFKPDDELHKQTAAWIWYHLYNVELDIFCLEQNCHCVRKQNEKLLLSGGSADDFYSYPEKYGGEQCSIEVDMRVIDQLLDEAVEGKQHMCYVDEDFEQLAIAAHVAIGFPAITLHSAWSVFRHMIAHLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8S2</accession>
    <name>A0AA38K8S2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793462">
        <property type="protein sequence ID" value="KAJ3782649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8S2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="493" mass="54935" checksum="FA5691AE290DB783" modified="2024-01-24" version="1">MQTDTGPSSSEVQAARWQTLLSNPLLLSLDLTQELNISNAGTTLFSSYAGLLAGLPEPLTAASLFSPALLLRIIDLLNELQAEVKSIKEATLNAVSHIETSAVLSDSQKNDVLAAAKMAVFDPTRVVFSNDSIVSDGYKLLEKYQSRNAFTPHFTSPTTKFAKLMRDELRTQASYAKTLLKISYLKTLYGKHASGVTKATQYVALAMTGSDDGVGLRETARALIMRKFIREQVDKKKIKVPAFITQKTGSKKRRRLKNSLQTLDLSPGHSDANETEDDGDKSDRNFWRTLNDWFKKRTVGKASDESELDDNSIEDSEFWGPNLTEEKWHEYLEECLNEEAQQYPQDKVEIVPRRARSAPSFSMLPMLSPLSTNNMTQNLHPQRTLSANSFMASLGIMPEIGIHDSDRESLDRFTTGNTMTQNCDASSPIRLPHINSFDTNTPISNSRNLEVRHTPGSSLGEVFQAHSTQRTHEDQNHPRMSMSSLLRPDSSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8V4</accession>
    <name>A0AA38K8V4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_68827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793446">
        <property type="protein sequence ID" value="KAJ3782904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8V4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="777" mass="85091" checksum="536A94879C23A8CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K917</accession>
    <name>A0AA38K917_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_429035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793421">
        <property type="protein sequence ID" value="KAJ3783399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K917"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="510" mass="55052" checksum="B1694BDDE00FE64B" modified="2024-01-24" version="1">MDNPQYYQPLSHALINPPRSSSQSQFYKTPSMDQQAPSGEQQKVVESDDDDEGMVEEQLSRTSAPPSPKPQAALHEPEPRRRGRPKGSKNRRGRISSQTVKSSPPSHQQLHATGQGTNPPQLPEVTAQNQQYYEFQWRVLNLCAEFYGAAEELVKGTPALVIAQCYQMGPSSKVDPLSMLSEAKQNCDTLLANPSRLITSPPPPMYPVVPTFYSASVPPGPMTSSGIPAGAPTMISQPQTFVVPMGNHAYYGPPPSQYPTTSYYSYPYGHPGAYYTPAVAPPPAPPPATPTAPPPTPTVSITTSVTGNSGAWSDEEIERLKSLAEEKRTNSGEIDWDDITSHWGSTRTRHQILIRATQLGLKESSTVRGVKRRRETDSNGDPTSTTPTPTPTASASAVRNPSSTPSSTPVASPSLQNQQHPSNPNSKAPAPISTTPSTSANQPWPMPVVAANTSSPVIGSSASDHRVTSYYRPRLTDPSSRPSSSTGTSQLPTVHRYMYQPNGHHSENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAJ2</accession>
    <name>A0AA38KAJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_311282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>melleolide F + FADH2 + chloride + O2 = 6'-chloromelleolide F + FAD + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:167712"/>
            <dbReference type="ChEBI" id="CHEBI:167713"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:67161"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793317">
        <property type="protein sequence ID" value="KAJ3786339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAJ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140907">
        <property type="term" value="F:flavin-dependent halogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3786339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="69642" checksum="DF7B4B1368F35A57" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAK9</accession>
    <name>A0AA38KAK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RAD26-like SNF2 family DNA-dependent ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_419702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAK9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="46"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="449"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="737"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="868" mass="99751" checksum="B2D7D4A5C29A4DCC" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KAY9</accession>
    <name>A0AA38KAY9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_265814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KAY9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF4">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="345" mass="37633" checksum="60AA0280F56E8EA0" modified="2024-01-24" version="1">MTGHPNHEPISARELVARKETAAKRHLVARSCAESIASHNLRRKAKRSLASSQMQAMVSIYFLSRLILSSSTCVLAPEAMEGPYYINNEMIRNNLTEGQLGVPLTLDIAVIDVTTCEPMENVLVEIWAANATGVYSGYSAMIGGKPPSRGDGHHSQPEKGDHNKMPNGHGHGHEHKPGHGRPGGPEGPHSQPLSRNETFLRGGAPTSSDGVVELVTVYPGFYAGRTAHIHTMIHMNWERSDNGTFVSTSGTVLHIGQFFFQETWNDKVYATSPYIENNNKRTHNNEDRQMEDSEDADGNSAILDISAAGEDLTEGLVGFVTVVVNPRASYQITNNNYLNSTNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBN2</accession>
    <name>A0AA38KBN2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_369445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793745">
        <property type="protein sequence ID" value="KAJ3780418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBN2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041386136" evidence="1">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="32294" checksum="323694AA76BF0AF7" modified="2024-01-24" version="1">MHRSWRLLSLAFIVLISVSSVCTFPVKTSPQLHSGGSPVNDVNTSSTPSNKVTFRWSEITRFNAPLTKAGELKDELSLSESRIRDLMVEAADVLGLDKSPPPEVERVDEGGVEFEKAYRNGFVRFQILGGTKFAGKEVLGVIYVGLEEQLLRRWDAKILVDREEVFPNPQIHSGGSSITRFNAPLAKAGELKDKLSLSESRIRDLMVEAADVLGLDKSPPPKVERVDEGGVEFEKAYRNGFVRFQILGGTKFAGKEVLGVIYVGWEEQLFRRWDAKILVDREEVFPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KC64</accession>
    <name>A0AA38KC64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_118449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="MU793586">
        <property type="protein sequence ID" value="KAJ3781228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KC64"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041463464" description="non-chaperonin molecular chaperone ATPase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="650"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3781228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="676" mass="73679" checksum="AFB7CAA535EF238F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCT9</accession>
    <name>A0AA38KCT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_391434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794276">
        <property type="protein sequence ID" value="KAJ3779741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCT9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="274" mass="30893" checksum="80A52152EA1ACBEE" modified="2024-01-24" version="1">MGHMRNWDTFTVHWREQLDERFNALNIEDTANQDAAATSYDKMQDTLPVPQLGNEPETVEAYRLDFTEYLRSMTRTEDGGFQATTDPKKTKIGHTGTRPVRKAKDNRCLCAFMEINGVMAFVLLDSGSTADAVSPDFARVSHIKPFQLENPVTLQLGTKGSRSRITFGCTSRYRILGGKHGDVTGKDYFDIANVDRYDAVLGTVFMRKHGIALDFERNVIRLSGKEIPTLTKGDENRELARRYAKNVSSNIHLQEGEELPVKSRPHKHGIVSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCW1</accession>
    <name>A0AA38KCW1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_407857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793467">
        <property type="protein sequence ID" value="KAJ3782578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCW1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041267279" evidence="2">
        <location>
            <begin position="24"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="246" mass="26813" checksum="252BBCA8AE1F1FAC" modified="2024-01-24" version="1">MHSSNFNFLVLALFMSLSLLVQGNSSKPFTFERLDINNTALLIVDLQVGLIPLVRDYEPDEFRNNLLAHAAIGNVFNLPTVLSTTSETGPNGPLVPEIVAMHPTAPYIKRQGVIDAWDDPDFRAAVQATGKKQLILAGITTDVCATFLALSLRQEGYSVFVNAQASGAASKTVAEDAKARMRDAGVYVVSPYALVSDLLRTWANNSYNVQTIGWDFAYWTLRGYMTDAHAAAIQNGTLVPGELDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCW4</accession>
    <name>A0AA38KCW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_231140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794122">
        <property type="protein sequence ID" value="KAJ3779861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="2">
        <location>
            <begin position="108"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3779861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="684" mass="77172" checksum="89CFC76CF7A25975" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KD65</accession>
    <name>A0AA38KD65_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_380880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793811">
        <property type="protein sequence ID" value="KAJ3780281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KD65"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="5">
        <location>
            <begin position="304"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="575" mass="63545" checksum="F144BE9B481F80A3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDF6</accession>
    <name>A0AA38KDF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_136434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793670">
        <property type="protein sequence ID" value="KAJ3780701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="81"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="547" mass="60447" checksum="54756114148E4C89" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDN1</accession>
    <name>A0AA38KDN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_359827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793403">
        <property type="protein sequence ID" value="KAJ3783793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDN1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="41"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="184" mass="21162" checksum="9B42115EE1DF2B9B" modified="2024-01-24" version="1">MNAHKDVVEPSHWPKNLRYIQFYTYHSSVSLETKNFLGRGPKFTDRRSPSRFVAIRHITDPLHPAYNQYGLFASKKIPAKTHILDYFGEIHADERLTSDYDLSLVRLQSGESIGIDASTTGNEARFINDYRGVKVKPNAVFIDYRTDSGELRMGIWAANEDIKKGNELLVSYGKAWWKARTEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEA3</accession>
    <name>A0AA38KEA3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_313784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793355">
        <property type="protein sequence ID" value="KAJ3785038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEA3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="268" mass="29791" checksum="2E2D24ABAB736681" modified="2024-01-24" version="1">MIHKQTSIPIPEPILDTTLDVISYPYLLTPPQPLQSSSIIPLSAARAQNLLTETQEAFIDLTLGQLLGQLHTGVQNDWFGRPSISQPSEPSYSWQETFTALLEPLIEHAREAGIDLGVSYPDIRTYLSRAIAFFLFDDVEVPSLIWFTGSEDDIYITRPNDTSPSVQIAAIVPTLAHSLWGDPLLESFFLPPAPSKAVQEGYVGGGGNPLLVFGRQKTKRLWYTVFLALVVLVEREGLQATDSDFGKRLWALNTLERCFQALKDAPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEF9</accession>
    <name>A0AA38KEF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_297390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793457">
        <property type="protein sequence ID" value="KAJ3782741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEF9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="68944" checksum="6EB6C1BB30FB95F2" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEX9</accession>
    <name>A0AA38KEX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H2, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_389206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEX9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="275" mass="29604" checksum="25B2614359BE97CD" modified="2024-01-24" version="1">MASSTKTPVHKKHSRISITSATSNALPQCTPNLMPFHIAYTGPAPVSTYFRVDDAKTQVGCPEPAQDDAQAGTSGPSIESFPCDSDVAKSLSSEHNGIISISESGTEQKLDGCGTSESSSKPIPNGQPRFTSTFRGRIVQGLKVDIPEGYTGVVFRSDDDTGESQNVSKDEPPSGKGKGKPTTAVQQNQRRTTRRSLRSRAVDDETMNIDAEEQQEDVLNSHSTLNLAPSSKFESFVLWHPDIPVDTGRDEYMSAIGEWMRIASVLHQAPPGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFN5</accession>
    <name>A0AA38KFN5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_333957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFN5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="659" mass="72072" checksum="56831083EEA2878F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFP6</accession>
    <name>A0AA38KFP6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_388286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793376">
        <property type="protein sequence ID" value="KAJ3784436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFP6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="381" mass="42031" checksum="1DB10D85FC869E6C" modified="2024-01-24" version="1">MLNLPLTAPDRFMPTVPNDSYPKLLTPVAENRSERARRRNAAYESAVRLPISNTPPLTSFNPIAESPSEPNSGLETDTDASAPDTSVQSHDVAAFYGPREVLHVSTGAGVYGSALGRGFDYNESISAPVTKPVATLVPSRRSVNDYRDDNGIRGRSPYSPTQGRNTRRREFSPITSRRGSSESGNLRFRSESRSPSSSGRNAGLRRAGDDSDAHERAEGTLRSTPDEHDSGRSSRMSSEPSNQKLWRPQEMSVAMSSGKPEVFLSTEYCKLVLEDPEFSWRSRSVRALIVPSLCSPMILGLPFLTFNNLVMDYSARTVIDKSCGFDLLNPVIATPVLPVLAPVKRRRILLRSQQELLKSKKLVFQQAASLAHIASYEYQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKE8</accession>
    <name>A0AA38KKE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="12" type="ORF">GGU10DRAFT_430379</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793885">
        <property type="protein sequence ID" value="KAJ3780149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKE8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="137"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="373"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="140"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3780149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="494" mass="53430" checksum="EE5333665C537D3D" modified="2024-01-24" version="1">MSEENTAKEWILDAETEYRFELDAGTSLAITLVRGRAEIFGAELVERKPYLFGSECKAAVFTWVGCTIEVTGSPSTEYVSDETPMSAYGNLHIAFEQMRVKALAKLHGSPVPEYAHPAQSKTQSDFSAEPPRVLILGPENSGKTTICKILVNYAVRAGQGWSPILANVDPNEGGWACPGALSAAAIHGPIPTCSPANPLGSAATSAPATLSSNAILPLAYWYGHAEMKRNFLLMDRLIRNLGINVQEKFDQDPEGYTAGIIVDTPSSFASSSGLGVNDHRQKLIRACIDAFRINIILVVGHEKLNVEMQRSYGSLLTVLKIPKSGGVVELDHGYRERIHKYQMHAYMYGEMIPSPPGIKGGTQGGDTLTDFILTPSSNVINFSDLTIYRIGAETMAPSSALPIGATRVVSEMQPVLVDPAQPGSGLLNAVLAVLAPYHPDENERYDEELLDLTVLGFIVVTNLDIPHKKMTVLSPTQGSLVGKTAIVGSYEWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKP0</accession>
    <name>A0AA38KKP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_369347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793733">
        <property type="protein sequence ID" value="KAJ3780464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKP0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20265" checksum="455CA04D02E4C0F3" modified="2024-01-24" version="1">MKSEEWKSKQYCACGAIETIEHIIFECKLHKAKRTWKLLKETWTRIDNKGYKLPKLNMNIIKGLSCIRMNKGKGRRNFEEDKSVTKRLKTLIGLTVWTIWKNRNSRIFNETVVTKKLLMETWKTTLRERISLEWKIIDLNPRTKGLEQTKFADKWANAVKIPDKGKALAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL53</accession>
    <name>A0AA38KL53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793753">
        <property type="protein sequence ID" value="KAJ3780405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL53"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="126" mass="14481" checksum="B306C5B3B7CE8F85" modified="2024-01-24" version="1">MDSQDIIAYGKVVPEKFWSERERVKNLCDWENLDFEIDGFVRVPDLDSPLIQDGNGLLSDTRIQLDLTRLVSFYDTMLVPGSLVPERYGKERIKHRLLGIFPKDLQAVARKIEELSAVWTGPLSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMC7</accession>
    <name>A0AA38KMC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER-golgi trafficking TRAPP I complex 85 kDa subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_88211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793502">
        <property type="protein sequence ID" value="KAJ3782070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="2">
        <location>
            <begin position="675"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1320" mass="147015" checksum="2734B24EA95D77BB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMU3</accession>
    <name>A0AA38KMU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_363043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793459">
        <property type="protein sequence ID" value="KAJ3782700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMU3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="203" mass="22206" checksum="5C8A7DE7CA3A981C" modified="2024-01-24" version="1" fragment="single">MERRELVNKGLADPVPSPPDSPEPTRKVKAKRSKIHSAPALNQETISLPEIEDIEILECELHAPKSRFIQCLDVANKALKQMKDSTRISLIQVVNDGFTRATRAKLQGRGRPGAWSALSPFRERSLSPLEEKVARLESSRRNTAYDSESSQRGTKRPRSEHVDNAVTASGSQPQSGTTRRGSGISKAGSSKASKPGDKGKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KND8</accession>
    <name>A0AA38KND8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_37666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KND8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="12"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3784064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="516" mass="56399" checksum="A6B550BB7F593B61" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNM2</accession>
    <name>A0AA38KNM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_126799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793629">
        <property type="protein sequence ID" value="KAJ3780921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNM2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="268" mass="30006" checksum="C8C4955C0648D27B" modified="2024-01-24" version="1">MMSSSRSEIIIVTYSYMPQQVNTNLPDLVIREVTSGVWTFSRPFGRGPLGLLPWGGRSTAVKLHNGDVFVLASTPLTEDTKSAIDALGTLKWIIAADIVHHLFIGQYKKEYPEAKVIGVEGLREKKEKNKESLMIDGEYGVDPPETLYGFEDEIKACYFSGFANKDVAFLHVATKTLIVADLLFNLPGTEQYSKSKASPKVPIIGKLNPESSMHKRLLWTIGKDKDAMRRDAKIVSGWDFERIIMCHGDVIETGGKRAWEEAYSRYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQ89</accession>
    <name>A0AA38KQ89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Choline kinase, cytoplasm</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_355349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793347">
        <property type="protein sequence ID" value="KAJ3785265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQ89"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="467" mass="52604" checksum="CCDE4A268BE4A9C8" modified="2024-01-24" version="1">MLARAFLRSSRPSLLSLTVIMTKVSPVVTPSLSSTHALETPSNIRRVSTSSVQSLVGVIASAASSVSSIPFSGEPEVVKAEGLRHASIFLDARQYKKASFLVQLLECIRTLKIPLWGPKITAEELMIHKVSGSLTNAVFFVSCPSVKEVPTILLRIYGPSSGSLISRPRELHTLHILSSRYNLGPKVYGTFENGRMEEYFPSKTLTAEDMRDPQISRWIGARMAELHSVPVDVIEETSSENGGEGNGWQLGAKKNVRSWLSPAKDVLMHPNIPQSVRDEFDLDRFQQQWERYLAWLSNVDDIHNGSGRVFAHNDTQYGNLLRLEGVEVRAPHRQLIVVDFEYASPNPASFDIANHFLEWTYNYHTSTPHLPDECRYPTPQERENFYQSYLEHTGHSSGDQLSQQVKSLEDQVRYWTPACHAMWCMWGIVQATDDVIGDVTEPEFDYVGYSRFRMAAFRRCIAALGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQJ6</accession>
    <name>A0AA38KQJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_296387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQJ6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000004">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3783306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="169" mass="18780" checksum="0D81FD3BFDD24DDD" modified="2024-01-24" version="1">MSNPCKRRLIRDFKRLSSDPPGGISGSPCPDNIMLWNAVIFGPADTPFEDGTFKLVLTFDESYPNKPPTVKFLSRMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLHDPNPNSPANAEAAQLYRENMKEYVRRVKATVEESWLDPGEAENADTEMAGASATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQK3</accession>
    <name>A0AA38KQK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_192699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793335">
        <property type="protein sequence ID" value="KAJ3785670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQK3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="459" mass="47114" checksum="ABE80AB0F428B141" modified="2024-01-24" version="1">MSAPSISSEALPSTPAHEWANETLNSVPSNTEDSTRVDVSAPSTATTPGLDFPGAYPKTPSTQVPLGNTSVVSSTGLPDAIANRAKQSGTIAAATVGDAANSLPHVGSLGSVGGGLDGVKEALFNATVTASQYLPPKIVEYFPGGSEIVAASNVENRFKDAQGFSLPSTEHSVDPTASSQGVGSLPGSSSEAGVAKLPLEREIDSNDNLKVQHEDLGTKESLTNASMVAQYGSSVPTPTMEKVSVDAESIPSHFKEDLDQKIPDTVTSSTAIDANIPVPNIPPITTIPIVHTASTPSTLPINSPARSSLPHSPQSKNESTIANVGHEKPFSEIPSTPSLTSNADTATTASPDSPDSPTTGSTLPKDTVISGNHTKNVSASSAFSTSSSGSAYDSEIARGHDKSISSPSGNSDSPSGTPTRKKTKLLTKIKGEAKIISGKLGGKEEKVEEGKRMLRGEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQK8</accession>
    <name>A0AA38KQK8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_396382</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MU793424">
        <property type="protein sequence ID" value="KAJ3783336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQK8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="67"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="334"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3783336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="718" mass="82351" checksum="1BCD979AD5E615F4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR60</accession>
    <name>A0AA38KR60_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_272175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793391">
        <property type="protein sequence ID" value="KAJ3784086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041248837" evidence="1">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="176" mass="19352" checksum="C3511B1C7FBFA5C8" modified="2024-01-24" version="1">MIILISLLVRLLSVAATTAPTLTQFDQQRFHDRLWQTNLRGPRWTGNDNQNTLTSLVSQSMQLAGLDVQILNYTLDRWDPQWWSLSLALKNGTILGLPTTGYWPYSGDSGVAGVTGPVHDAGTFSVSDVTEKAVNSSLNLDNLPPGGSVLFFDNPSPTHNYSLPGYKLLGYVIQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR70</accession>
    <name>A0AA38KR70_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-lactaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_351898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793315">
        <property type="protein sequence ID" value="KAJ3786390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR70"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="354" mass="39143" checksum="9CB6098F781D925A" modified="2024-01-24" version="1">MPVVLPGSTILVTGANGYIAAWIVRTLLEKGYNVRGTVRSKEKGIRMQEIFEKYGDKFGYVLVPDITKEGAFDDAVKCVDAIAHTASPVNFSTVDPQDLIQPAVRGIKSILRSATQKGSNVQRIVFTSSTAAVLEVDPKPRIFSEDDWNTQSVAWVERDGKDAHPITKYRASKTLAEQAAWKFVEENKAMIKWDLVVLNPPFVFGPITHDVPTLSALGLSAGMFHSIVVGHSDAGGKTPQELRSTGNCWIDVRDLAEGEVLAFRKEEVANQRVIICAGAFVWQEWLDVANSIAPDHLPSHSNLPKGVPISSSDPEIVYQIQYDTSKADRLLGIKYRTKEELIKDTFADYEARGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRW1</accession>
    <name>A0AA38KRW1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_331702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793296">
        <property type="protein sequence ID" value="KAJ3787230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRW1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041389957" evidence="2">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="208" mass="23981" checksum="57CF898F41D9D39C" modified="2024-01-24" version="1">MRFSLLLNFWTACLVIGLISVVCAAPRPVDNAMASLSDDQSLPPSSPFSTTVEIQPRSSLKRIDVTFLYPDERLTTDNEDAWAQIVIRALIKEAAGVLDIQVRAMPWVHFYNYPGHWTRDMVLEAELFGPDVCKQKDLRKPQDCTLRAARGSPGYYEMEIRNGAGDSVFWKDQISVEEEVERYNARVKKQTQREQKQRLKDRFRPTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT19</accession>
    <name>A0AA38KT19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793983">
        <property type="protein sequence ID" value="KAJ3780012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT19"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="774" mass="87927" checksum="A9B9DC02184F07EE" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTP9</accession>
    <name>A0AA38KTP9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein 9/12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTP9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="89" mass="9569" checksum="EB75C5DE942F60F9" modified="2024-01-24" version="1">MSDTGRQDFTDKIKSDLKPESQKSTTESWTDSAKSAADSLASTGEPNSQKSYTQQIFDSSSSNSNENTDSLLTKAQDALGLGNNNNTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTS3</accession>
    <name>A0AA38KTS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_385791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="301" mass="33313" checksum="1134466163836AEF" modified="2024-01-24" version="1">MTDLTVLSSSPLPLYPLVSASRSSFFSSYVPGASTSKVNLVPTDALKGHKPERPARLNIQPEAHRREEDEDEDGHREQNEQDEVEVESPDSYVGSQIQAGWNRSGHSWQLDPASSTLQNLAPTPRGRTKPQQHRPTRSRSAPPMQTIFSEPLPKPFTTAVAPDTATFELHRSRRYTSSSTYTTSTESSHSSPSSSFSSPYSWAGPGYGKSRNGDLLRPPPPLHRPTTFWRRTPRSGVTASSYSPASHLIRRSTFIAAGLPFERPVADISALGVESRVKAQFDEDNARAKVSEVFWEVVVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV44</accession>
    <name>A0AA38KV44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GGU10DRAFT_316963</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU793423">
        <property type="protein sequence ID" value="KAJ3783357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV44"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041274388" description="alpha-amylase" evidence="18">
        <location>
            <begin position="28"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="40"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="56"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3783357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="512" mass="55731" checksum="7BB32B3F8C141610" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVG8</accession>
    <name>A0AA38KVG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amine oxidase</fullName>
            <ecNumber evidence="7">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_272036</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="7"/>
    <dbReference type="EMBL" id="MU793389">
        <property type="protein sequence ID" value="KAJ3784122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVG8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0801">TPQ</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="11">
        <location>
            <begin position="275"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="10">
        <location>
            <begin position="356"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="848" mass="95608" checksum="73331BFA9ACBD779" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX55</accession>
    <name>A0AA38KX55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_379518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793556">
        <property type="protein sequence ID" value="KAJ3781463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX55"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041449648" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="241" mass="26790" checksum="1F161EF3A069096E" modified="2024-01-24" version="1">MRHFIFVCISLLTLLPSFVFGITSDDVAKLRGIKAQEMSKTVTSQDRTTYFSHDISGRLSQAKKLAGAKGKYTKAIYTWTEDGTSVIMKILSLKASRDEVIGEAKALSKLNDLRGTGRVNMRSIIHNKMFPAIIMSKKTGESYFSSQAYKQTHKKARGALLQSVKEKVCEEVARVASTTGILHYDNQPDNILITFSKDGSNVLSVQLIDYGPPYTYAVDTSVSKESIVDVCQSSSVWKLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXC8</accession>
    <name>A0AA38KXC8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_144555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793292">
        <property type="protein sequence ID" value="KAJ3787437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXC8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="683" mass="75957" checksum="4662FD31724D9D15" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYE3</accession>
    <name>A0AA38KYE3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal domain of NEFA-interacting nuclear protein NIP30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_253929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYE3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3788997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="178" mass="19771" checksum="B8315619AA2047AE" modified="2024-01-24" version="1" fragment="single">MDDSTAIPSLSMGAVGSRFVSSDEIEIARARRDEQWKAAYARLGQEPPPQPQADAYDGRSLAEKLAANRAAKQEEWEEKSKLANQFRALEEDEIMFLDSLREKEEAEEKSRRERDGEEVKGFKEAVAARIQQSNAPPPSMGSSSTAKPSVPKKDTKLPTTVKKDIKKPSLKGVVVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZ60</accession>
    <name>A0AA38KZ60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_356357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793359">
        <property type="protein sequence ID" value="KAJ3784913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZ60"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3784913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="391" mass="44354" checksum="A5C41AA7090F8D7C" modified="2024-01-24" version="1">MDPGIPLVVDNGTGFVKVGYAGSNFPEYVFPSIVGRPILRAEERVGSAVIKDIMVGDEAAQNRNYLQVTQPMEHGIIKNWEDMKHLWDYTFDEKLKVDPRGRKVLLTEPPMNPKANRQKMCEVMFEEYGLGGVYVAIQAVLTLYAQGLTTGVVVDSGDGVTHIVPVYDGFALPHLTRRLDIAGRDVTRYLIKLLLMRGYAFNRTADFETVREIKEKLCYVSYDLDLDTRLSEETTVLVESYQLPDGRTIKVGSERFEAPECMFQPHLVDVEQPGVAEMLFQTIQNAAVDVRADLYKHVVLSGGSSMYPGLPSRLEKEMKQLYLTRVLNGDPSRLNKFKIRIEDPPRRKHMVFLGGAVLADIMKAREEFWISREEWFEQGVRSLDKLGRGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZW4</accession>
    <name>A0AA38KZW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_351651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793313">
        <property type="protein sequence ID" value="KAJ3786473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="76" mass="9137" checksum="3DCD374890F59BC2" modified="2024-01-24" version="1">MFKSMLHDAKLRDPSWLQTRRALEIIRKLSIDYVNFIEECWIHAFQPWSRPEPLQLNSEHYRSLFNILFVCGSLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0L7</accession>
    <name>A0AA38L0L7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal calcium binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_384910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0L7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.120">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041358874" description="Fungal calcium binding protein domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12533" checksum="5184FB6E853A3AB0" modified="2024-01-24" version="1">MHFSVVAALFMYAAAMVSARPLPSRLNGEELWGRADSSSSACDGQAMKTCAIALVPSVATCGLAAAQGELDVINDVACIGAAVELGMDFPPACTACAEKFGDKTKSLEQKITTEFSKFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1P6</accession>
    <name>A0AA38L1P6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_380918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793821">
        <property type="protein sequence ID" value="KAJ3780262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1P6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="239" mass="26588" checksum="F64EFCB6DF4A67D4" modified="2024-01-24" version="1">MSHFLRSVLPLLLDQMEMRPAGTMMMDRTILASDSTRERAPTTASTLSSSPSRSLQKRTVRFSPAPASPRTPSASTSRAPTSVVRNSDSDSDTGASDPAAMDMELEEDPAGIPKPDGEAGRPGRGGYNLQTTLAWSAKRWRDVKGFIRNRVRATLDCSLCFSDQPLQRLHDIRQEAVAKYSFLQEYEDLWAVDDLIRSRLKYEKVALKRKADAKLAEEARAKAKKRFTISLPASRRASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L274</accession>
    <name>A0AA38L274_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794484">
        <property type="protein sequence ID" value="KAJ3779635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L274"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="20391" checksum="D95299BDBEC11B48" modified="2024-01-24" version="1">MLSKKERASSAPVFPPFRDVPRVDIRDFPTSPTRRPLHSREPNFRITFGSLFPLSKALESIPDEAKIPATPTPTDRLVPTGIHAAPLSPLTPLPKNSLIKKLAEADANTEDRFAASGWGQSNEVSQNNGSTSNYRPKFRYRARCSRQTFSDSSSPVYKCHCIFIENQILRYATSCCPGKSGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L283</accession>
    <name>A0AA38L283_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_437206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793542">
        <property type="protein sequence ID" value="KAJ3781597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L283"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041229454" evidence="2">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="143" mass="15832" checksum="F4EE848182113113" modified="2024-01-24" version="1">MGNLLWFFLGAGAATMYAKRRNHLEHEGRCSHPHSARNISSSPEIDQPASTQKNTFIPSAPWNSHSASVASPASGHSSILSSDPWAVEKERIREIGSQVGDNVLDFSESTLDTLLSNIASMKAKIVQQRLDRERHEQDPLRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2T1</accession>
    <name>A0AA38L2T1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_81077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793477">
        <property type="protein sequence ID" value="KAJ3782422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2T1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="99" mass="10996" checksum="A0E61B2DE90C44D7" modified="2024-01-24" version="1">MSPSSSSKLESSTSRSEKCRIAEIIQYTCELEQSQTEGHVIRCFPLSRLFKICPGRPGIELTKVLNVDEGGVVELPDNIKQPIGKLWHEVIRHGSSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3N5</accession>
    <name>A0AA38L3N5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_41153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3N5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041442816" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15675" checksum="6310C43424BA0BE5" modified="2024-01-24" version="1">MCITVPLSLAITILTALCNLLAADDLTPFFMLTAEVEVLLHVHINRNPSCNFLDTLRSLPRRNRSSPRKNHALSRYFCAAGTLFLNVFLLHFLRGYQHRIQSLSYSRDEQQANRHSHLHKFPTTSGHASYSLIAITDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3W5</accession>
    <name>A0AA38L3W5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_275605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793478">
        <property type="protein sequence ID" value="KAJ3782395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3W5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="20291" checksum="2D650F37A28C1F32" modified="2024-01-24" version="1">MSDNSSLQQLAQWAQSKINALYEHPDTSLPDDNSAPPIASRVQSLFAPTAQIYLNHTGPVPPEEFSKQLEKSFGTSRAEVEWKECFEVLDDNEHDAESETVIVNERFTRYQVGIVAGYFIITRTLKFRIRAAPAKNYTHVSFSAKYKSIGDRDTRQIVQLFYTSMSKPAPVHIQGVHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L429</accession>
    <name>A0AA38L429_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_362859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793455">
        <property type="protein sequence ID" value="KAJ3782770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L429"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="168"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="322" mass="35590" checksum="D92EB3A1B6A3C943" modified="2024-01-24" version="1">MAVPININTTLGFLSHAVVLCCILYGAGCMQAWFYYRKYSRRDSWAIQVLVAAVIICDTCQIGFLYAAVYNYTVTNQGNPLALAKIDPNLIIELIFSGMIAFLVQHFYCHRIYALSKSRLLAGLVSLTSLGSLVTLYYFIGVVLSQYTELAQLALLDNISVVTNVLGIVSDLAITFLMIWLLQRSKTGFKNTTDVLNRLIVFTFNTGIPTSLCSIVTLILLEGVPGTFIYIFVYVSMGRFYTNCLLVTLNSRDYIRQGLSSNGASTSENYAMSIPTNALESRLEFAGTGSTAEGISIRIDRDTHTSSPKHRRGDSIDLPQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L455</accession>
    <name>A0AA38L455_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_399924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793361">
        <property type="protein sequence ID" value="KAJ3784852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L455"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="627" mass="69387" checksum="CCBFB5BF4D7FB8F4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4I2</accession>
    <name>A0AA38L4I2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_422590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793340">
        <property type="protein sequence ID" value="KAJ3785512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="327"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3785512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1453" mass="163902" checksum="8A7AD01C3605F777" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4U6</accession>
    <name>A0AA38L4U6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_35008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793388">
        <property type="protein sequence ID" value="KAJ3784150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4U6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041423513" evidence="2">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="251" mass="28597" checksum="E7451EBF3D426679" modified="2024-01-24" version="1">MRRSLFHLVPLFFCYLFFFAFALPFEPQRTVGSDSTEGQSLQSLQTRGLPYFISPPSPSSPPPLSLPPPELSPHPFRPQEEPPRPPQRSQTQQGHRTQRQNPRPLQRPAAPMNPSQTLRLPVIQIFFPQCAGVPESRERTQDATGIVRRYLQSSSRPPYPFRRLTFRNHYLSLVEDQIHFKMIDFHYRAYCNPSCDGTAFLVNINGSTFHHGDLVYNGTVPTEFLSTADILNYAPLPPPPPPHPHPRPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L533</accession>
    <name>A0AA38L533_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_266651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L533"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3786622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="340" mass="39482" checksum="02F27E938125479D" modified="2024-01-24" version="1">MVKGTDNLKSYVREAMLPRMKNGKYAPAMPPEGHKSHMNTLKVRPETWRRLENIYSLDYFQLEEAIIAWIDMHLPEYPLEAEDMDEDTGETLSIPCPGTDFEIMYREERKPSDLSRLAPWLDNLALMTVQRIIHLIHPASQIWSFFLSDEGDFDRTIFQHYLWTVPNYILEGLDENRRKSVEYSSVVIAFQPPWILSAQDIKEFAKCRTFPPFRESGNAFPTPLDSTHRLWAKLWDLCVRRNTPWFVLTSYNHWTFGMFSKGWTAAFISGVYEYDHHSPTITECLTFWIASAMRIAVTLRYPKVCEEPSNSQTPSTVYDAMAQCPEAALALALLDQNHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5Z2</accession>
    <name>A0AA38L5Z2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_267557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793319">
        <property type="protein sequence ID" value="KAJ3786265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5Z2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="10">
        <location>
            <begin position="92"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="9">
        <location>
            <begin position="299"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="834"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="918"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3786265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1044" mass="110180" checksum="C2EEC40D72555046" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L694</accession>
    <name>A0AA38L694_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_394330</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793304">
        <property type="protein sequence ID" value="KAJ3786880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L694"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="496"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3786880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="538" mass="61272" checksum="AF7227A662917D71" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6A6</accession>
    <name>A0AA38L6A6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_427097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6A6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="164"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3786955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="338" mass="35930" checksum="2A8F6CC3361506C8" modified="2024-01-24" version="1">MPIPKTLLEQIKQLIPPLNGTLHKGQSGRVGVLGGALDYTGAPFFAAMSALRFGADLSHVICSPTAAGAIKSYSPDLIVHPILREELSPGDVKPELSSLLSRLHVLIIGPGLGREPYMQNYAKLAVTLARESGMFLVLDADALFLIGKEPELIKGYRRVVLTPNVVEFKRLSEYVGVDPSTPPDKRAEVISKGLGGVAILQKGAKDIIAIDTTGDAADTEKSHLRDEAKEKTKEIVEVDVEGGLKRCGGQGDILSGAVGTFLAFGKCYEDGAFGDGKIVASRMPLLAAVAGSMVTRNTSRLAFQKQGRGLVTQDMLGEIGKSFSEVFGEETQGDKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC03</accession>
    <name>A0AA38NC03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_77808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793469">
        <property type="protein sequence ID" value="KAJ3782536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="229" mass="25494" checksum="263F511D8BFAA1F2" modified="2024-01-24" version="1">MSVQERHISATDTAKDVHISKTRATIVLDPAQFESTADQWDLPVVKTTSLTRNRRRIDNELISRWSDTKHQSTKCSNDLCSSFVPLPSSAIPTRRNEVLGGYLKGRALSCSIQEELLPLTRMKTAKEIAQLMLDAVSALHWLTTKANIIHGDVNPNNIKARYEGDEVQGVLVHRDVASPIDHTIRVQFDVLLGRFSLDTVSEVVGGLGKQLAGDFREIPKQYFNCSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC84</accession>
    <name>A0AA38NC84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_361760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793436">
        <property type="protein sequence ID" value="KAJ3783106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC84"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="106" mass="12089" checksum="9399D60F61C47B64" modified="2024-01-24" version="1">MSSYFLLIEIVTIASSSVNLLLGNIPDVSAGTRAQFFDLLLTLSSFAVFFLLYETLITRCIWSTSKHLLNCDELRGIHIVSFPRRWLCRVLSPPDYLQRQHATTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCE6</accession>
    <name>A0AA38NCE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_334452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793403">
        <property type="protein sequence ID" value="KAJ3783811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="915"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="730"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="920"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1196" mass="128459" checksum="8F2AB85417F119C6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDI9</accession>
    <name>A0AA38NDI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_426913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793295">
        <property type="protein sequence ID" value="KAJ3787276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDI9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02509">
        <property type="entry name" value="GDP-M1P_Guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049577">
        <property type="entry name" value="GMPP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054566">
        <property type="entry name" value="ManC/GMP-like_b-helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22640">
        <property type="entry name" value="ManC_GMP_beta-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159283">
        <property type="entry name" value="Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP isomerase/GMP-like beta-helix" evidence="3">
        <location>
            <begin position="446"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="500" mass="53956" checksum="B4382DCAF26CCA24" modified="2024-01-24" version="1">MTVPPQLSSLSAGQNTSQLSVETMFQSIMAMMQQSQIDIADLKHECSELRLANTSLERQLRDNSQGNNGYYRTSTPGFMTPAVPSSPQMRAKSPFLSPAVPSTLPTLSAPVHHPSPLGDNAISNTSYFSAARDIPGFYVVIPAGGAGTRLWPLSREGHPKFLLDLTLKGRSLIQATWDRLLPLTSASRTTIVAGPSHVSSIREQLPDLLSENLFCEPTAKDSMAAIGLAAAILAHRDPDAVIGSFAADHMISGDDAFLAAVAEAVEVARNDYLVTIGIAPSHPSTAFGYIRLGEPINIKNAPNARLVSSFKEKPDARTAAAYIATGKYRWNAGMFVMKAVTLLKFLEEYKPEMSEGLRKIGAVWDDEKERNVILEKLWPELEKIPIDNAVAEPAAEVGRVAVVPATFGWDDVGDFSSLSDLLPAEANQPRVLGDPSLVLTDQVAGGIVVPGSGRLISCLGVDDLVIVDMPDCLLVTTRARSQEVKRIVKKAKDHGWKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NDX1</accession>
    <name>A0AA38NDX1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_330955</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793279">
        <property type="protein sequence ID" value="KAJ3788161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NDX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="150"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="617"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3788161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="751" mass="82611" checksum="97CE94CC17F82E53" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH38</accession>
    <name>A0AA38NH38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794823">
        <property type="protein sequence ID" value="KAJ3779477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH38"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22576" checksum="0F7353D5DCFDF799" modified="2024-01-24" version="1" fragment="single">MSTTSSPARPVRSPTPVLNKEDVELQAFLAAAQREAQEKWEKLRAAKTSGVVGKVVEGEAGVVGLKENVVEGVAEEEEEVVLKIILIPKKRRNVVETEVVESSRKRRKVVQSPVIVDTDSDSIPVPFPRPCERCIRGDQVCRPQANAPNAVACERCHLARQSCSFLQKSKKLRVRSPPNESDREEQRELRFTIEELTVQVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH56</accession>
    <name>A0AA38NH56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794410">
        <property type="protein sequence ID" value="KAJ3779672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH56"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="316" mass="36489" checksum="84D5BCA935C6E8DE" modified="2024-01-24" version="1">MSSPQKLTSSQIAAQLCQMQEQLLAAQEEERVEAERAKRAAKEQARRAAEERKKTEEKELAEKKRRIEEAKRAKAAKKKLEEAEKKRQEELAEARRGKAREVVPSQKRVRDDISDPLDPPYEEESMDNDSEQDEEPKAPKKKKRKGNNAQPIASTSSARPACTRCVEKEFDCRPQDQLNTVSCYHCRNDKVKSNPIVGDASQPTEIHERIAMAMEGIQDSMVGIAYELRQFRLQVGSWQDTILANRSRRARTGEALEALEIERELVELEEEEEDFVVELRRQKQEAELGEEEEDEEEEEEEEEEEKEKIVRRSAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH62</accession>
    <name>A0AA38NH62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794287">
        <property type="protein sequence ID" value="KAJ3779732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH62"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="241" mass="26475" checksum="48187C824C4833A0" modified="2024-01-24" version="1">MSETSSSSSSLSPETRQEIVTLIHEAFQSLNSMPAPPLAAPSQPPYTPPLTRNTAAGASSSLLSLFPEVEAASITAIITHNFRASDLYKLDSRYRDKTERQILSLKGETLELTTNDSAYRDYKSLNAIAIPLSTYFSILVSHAETSGKIASEYEWSAVIAYHMAFFNKRRREMQEGDYSGWGKVDMELRSGHRLCPPPSQTHAGSLTKGPACPTHVHLDAPIYAANARSLITELINALTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NH94</accession>
    <name>A0AA38NH94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793979">
        <property type="protein sequence ID" value="KAJ3780017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NH94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="168" mass="18127" checksum="3737E70ACE683AD7" modified="2024-01-24" version="1">MVVIGNENEEDEDEDRNDQVSTSISPSASQTPAQQSWSATSSMSSIPSTLRKRSAITKDSNDCPLKRAHGRKPTQSDAGFEMAEAVRDLACSAMGNGSDPLVLSPARKTGAIACLEQDDQLSDNEMIDAFKLIRHETSVADTYLAIGSIARCTRFIQAELSAALNDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI20</accession>
    <name>A0AA38NI20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_363075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793460">
        <property type="protein sequence ID" value="KAJ3782672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NI20"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="79" mass="8862" checksum="7EB8951F3F4F1DB3" modified="2024-01-24" version="1">MGGDGRYPYPKQVWSPAGGWWVRPSNWKSNTFIVATGIAGICYLVGKVSASKEQRYIAPTKQIPSAMWARQFQAEKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ29</accession>
    <name>A0AA38NJ29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_13513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793358">
        <property type="protein sequence ID" value="KAJ3784937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="28"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="7">
        <location>
            <begin position="400"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="470" mass="53160" checksum="A00145436A720DFD" modified="2024-01-24" version="1">MLSRQPILNHMQRGPRAFSSSCRREKQRLVILGSGWGGYEVLRGVDKKRWDVVLVSPNNYFNFTPLLASCAVGTLEFRCAIEPVRRYSPAAGIYQAWCDSIDFRNKILQCIPATKPSHVASPSDTAYDHSISTTSPGSGLSFPLKYDKLVIAVGAYSQTFNTPGVKEYAHFLKDVRDARAIRSRILECFEQANQPTLSDTERRHLLNFVIVGAGPTGVEFAAELHDLLHAEIWEHYPSLAKMARINLYDVAPSILGMFDKNLVQYAEKNFRREGISIWTSHHVNKVEAGKLLIKEQGEVPFGLLVWSTGLSPNPLIASITELKKHQKTQSLIVDDHLNALRTDDTPDPDVYVIGDAASLANTQLPATAQVANQQAKYLYKRLNKIIKDRPHEKPFEFHNQGTLAYVGNWKAIYDRPDEGGLPGLSKEKGRVAWLLWRSAYFTQTLSVRNKILVPFYWFLNWIFGRDLTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJQ2</accession>
    <name>A0AA38NJQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_118228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793585">
        <property type="protein sequence ID" value="KAJ3781234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJQ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041274239" evidence="1">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="98" mass="10752" checksum="01B7B4DAC0FABC29" modified="2024-01-24" version="1">MRFPVASFYVLLGLFAVGSSVPTGAKRLARLKLNQQTSFFAHSTYSVGDELKNVVDSTKPTVRFTFVLITGGWTNETAKTPRGCSICKIKRLSYTPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK63</accession>
    <name>A0AA38NK63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_335404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793465">
        <property type="protein sequence ID" value="KAJ3782598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK63"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16804" checksum="669FF3EC04D3ABFE" modified="2024-01-24" version="1">MEISRGIYNTISHTAVTMNLVESMQNQSSSNSLLLNGYVIEPFLPEAYHHGDTDTAYPPNRNENIHPMNIYYAWTSESSDSIMLDAARQTAASLQQIASSNGILASAKYPNYAIFGTPIGDLYGENADRLHHIKNLVDPFNVMGLTGGFKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKJ5</accession>
    <name>A0AA38NKJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_233986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793432">
        <property type="protein sequence ID" value="KAJ3783183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKJ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="75" mass="8252" checksum="EE719E129B79B090" modified="2024-01-24" version="1" fragment="single">VVACAIFAVSSYDYQSGGHLILWDLSLVLEFPPGTVILILSALLEQCNIIIKLGETQLSITFHSAGLFRWCHNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKN2</accession>
    <name>A0AA38NKN2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_56669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKN2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041247218" evidence="7">
        <location>
            <begin position="23"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="69"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="184"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="396"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3783333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="546" mass="60274" checksum="13CBAAC0D1524FCE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKR2</accession>
    <name>A0AA38NKR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_385672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="MU793288">
        <property type="protein sequence ID" value="KAJ3787652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKR2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000247">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="62"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="417" mass="46051" checksum="764A735498724ACE" modified="2024-01-24" version="1">MWSKARDIVAGDTVILWLTRDALQPLIIEPGKEFNSKFGSYRHSDLVGIPFGSKVGSRTGKGFIHVLRPTPELWTMALPHRTQILYLADIAFITSHLNIKAGSQVVEAGTGSGSFSHSVMRSIGSSGHLWSYEFHETRANKARQEFLRHGLSDRVTLSHRNVCKDGFTVIDTADALFLDLPAPWDAIEHAKKALRKDRIARICCFSPCMEQVLRTVSALNDAGFTDITMYETLLRPYDIQQTPALPTIADLSHKLKQSELRREEKRLKQIASGHRGGSEDENNGKKLPGVSASGPGYESSSSLSFGEKRKREGAEGENEEMLTGEPVGGKRAKTEEEEVVVVVEDTLSSTPGDVPMNDVPLLLKAERSFGEEKGEMPSLVQPMKINLSKVMPEVRGHTSYLTFACLLPPLPTQVTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKT5</accession>
    <name>A0AA38NKT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_50487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793414">
        <property type="protein sequence ID" value="KAJ3783543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKT5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="295"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="366" mass="43368" checksum="8A766F818BCC676B" modified="2024-01-24" version="1">MAQKRSFYSPTRPPTLAMTELVKMTLDHHHTADLITKWLEHPNDIYLDWFYSRREQKYDRDQRQMLLWNKGDFLLENIFCRTVDTGRLIPLRTWTTHVYCHCSIHDRKRTMMRVVFTMLPELMLLRAMHDRGCDEIFIIVTDLQRQEMDEVTEYFKLVCRHAFGSCKPGMEKRIQLEHMRITHAMHRQRRTPCFPQIDLALRAILYEKRPRFVILFSPPPTSYSQILFTHHSYVPDEEIFFEYPSGCPNPCCTDNCEMLRFPRRGLETANVLEIKRGGKFGKRVKQKTMCNWIECDVCFSEETLPKSTSGSSEGTESSENGTDPSVQRVVPGQLCSQCRLVRYCSLDHQRRDWPEHKKVCAKMQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKZ1</accession>
    <name>A0AA38NKZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_377720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793422">
        <property type="protein sequence ID" value="KAJ3783379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKZ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="83" mass="8902" checksum="1E83E9D203CA9ABF" modified="2024-01-24" version="1">MSASNNQQAPTEGTSVEHDLNSSLADQGGDVESERLRKKKPPHRPHLPSRDQVRKLVEAVGMAQAAAQLGVDIATLQAYLNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLJ8</accession>
    <name>A0AA38NLJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_82479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MU793267">
        <property type="protein sequence ID" value="KAJ3788957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLJ8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="90"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="424" mass="47696" checksum="367B1E415AE7553A" modified="2024-01-24" version="1">MSVSTAGPSTPSRKRSRWQNSDDDNEEDQQLIINPVKRRTKPKPSKEPASSSASVALPNIKIPGYPIHSIYVPPRTHHPHITPSRSVYCYERLNQIEEGTYGVVFRARDKQTGDIVALKKLKLDEEKNGFPITSLREINALMACRHDNVVGIREVVVGDTLTQVFIVMDFIEHDLKSLLTLMPSPFLQSEIKTLMLQLLSAIKHCHTNWILHRDLKTSNLLMNNRGTIKVADFGLARRYGDPIGVGGMTQLVVTLWYRAPEILLGAEKYSTAVDMWSVGCIFAELLLKEPLFQAKNEIELISMIFKLLGPPTNNSWPGYSSLPLAKTITLPSPHLHQFRQKFQYMTTAGIDLLMSLLTYDPDQRISAEEALDHPYFTESPLPKHPDLFGSFPSAAAGEKKRKVFDSPSAPTRAADYKLLTDFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLK6</accession>
    <name>A0AA38NLK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD binding domain of 6-phosphogluconate dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_357903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLK6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="5">
        <location>
            <begin position="193"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3784384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="287" mass="30596" checksum="EAE2C39F998C97BE" modified="2024-01-24" version="1">MSTPVDDLPRRFGWVGIGAMGFPMASQLLQKLPSSHQLFIYDVDTVVLQKFIQTNADPNRPTITIVSSPKEVVEHSDCFISIVPEGSHVKDVYLAPQRGAKLAADTAGKIFIDCSTIDPGTSLEVGRAVAASHSMNAPRFFDAPVSGGTRGAEKGILTFMVGAAEDDPQFPLLRRIFSCMGTSIYPIGGQSLGLAAKLSNNYLSGMIALATSEAMNLGMRLGIDPKVLSDCFKTSSGGSWVNSTVNPVPGVCPDAVTSKGYEGGFKVQLMTLNMRSEKTGRNMAQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLT6</accession>
    <name>A0AA38NLT6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_376312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793360">
        <property type="protein sequence ID" value="KAJ3784879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLT6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="24550" checksum="A5894A4EBE017547" modified="2024-01-24" version="1">MLEGSRPKTNDILCTTLVNPHQFKLGDAEMDENDPDFTELDRYDAQLDKHMLRPMAYWRVPVGNEEDDTPPKKPSAVQTQSVAMSLPFDKDSVSRSGTAAVDQVFENDNQQQASPHHRHHYRIISNDPMRRQTTMHELFHGRTDVTKRGVFLRDFNRLPDAQSYLSPSFGPALEILTELADVLTTAYTHSEKKYPAGIDDQYFMVHNDFLPFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLW2</accession>
    <name>A0AA38NLW2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_355095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793344">
        <property type="protein sequence ID" value="KAJ3785373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLW2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3785373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51790" checksum="D08D8054F27F773A" modified="2024-01-24" version="1">MSIFGSITTSPLISSKFQFRSRVVVAGSYQRYLRNTILRHCASVSTMLDSSSSADLPDFEVFEGEPELPLYTRRPSAGCSTVLVGRQQRKFRYSVEKSLAGPGITLTVYGDSKISNELPSFMAGDRVAGVVQISVNNGEDIRAVHISLRGRVLTGRTSDAVCTFLDLQETLWTEGSGSLEANVHSTNESDYIWPYSLVLPKDVAISQVDGEKEQVFPLPHTFTEPGVPARVQYELEVFLKQTKWKRNRRIATEIGCFQSNPNRIRSGYIPSTSSFQCAEADGVTRWKALDFDLTGIISQFHSRTVHFFCTLSLKDPLCYTRGSYIPLLLKIRSQDKQALELISSPDAAIVQLNRRINYKDVQMCGGKSSRWSSVVETVGAVTWKSHEGTLLEEPVLAEYSSTIIGKVKLKRDLAPSSVIANMAIEYFISVHPFSSPSFQPKDNKSGSLLSQMVQITTDLSSLSEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN18</accession>
    <name>A0AA38NN18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_370035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793959">
        <property type="protein sequence ID" value="KAJ3780050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN18"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="64"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3780050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="215" mass="23490" checksum="269F46E259151D18" modified="2024-01-24" version="1">MSNLPCYRSFLAHRVWQLSNGNMWISIPALLLVAAEFGILIRVHTFVELAEILKGLSITVNVLAAVGDTYIAGLLTLLLHTSRTGLRRSDSIINKLIICSINTGALTSLCAIASMLSILLAPETFIYISFFFCMGRLYANSLLATLNVRSLIRKEGSSNVQASGDTGSIPLGAYNTSVFNPPSAISVKIDTRREYVSDEEEQKHSESVRSQMDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNA3</accession>
    <name>A0AA38NNA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal RNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_110616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNA3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34716" checksum="4F0A0EA276DACBED" modified="2024-01-24" version="1">MFEFTSFRQPADDYVVNNVEDIDMDVDDEDLFETDGMNLTWPGKSLTSAQEYMRGHGTYVDNEEVIASVSGLVERVNKLITVRAVRTRYNPEVGDLVVGRITEVQPRRWKVDGNSRQDAVLMLSSVNLPGGVQRRKVESDELQMRSFFEEGDLLVAEVQAFFGDGTMSLHTRSLSYGKLRNGQLVTVPPILIRRLKSHFISLPCGVDLILGLNGYIWVSKHIKENEREGEEAFDAEAVYSNRNDVIDDSTRLAISRVTNLINVLASRSIPLTDTVLLDAYDWSLEQEGDVKDLLQEDAGDALVATILAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNB5</accession>
    <name>A0AA38NNB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_369306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793720">
        <property type="protein sequence ID" value="KAJ3780500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="127"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="726"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1429"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1026"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1430"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1492"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1541"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1568"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1606"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1641"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1656"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1773"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1899"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1952"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1973"/>
            <end position="1993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3780500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1993" mass="222851" checksum="F56D76C893BDDCDB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NND8</accession>
    <name>A0AA38NND8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_119500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NND8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="170"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="325" mass="36234" checksum="E922185FF493D375" modified="2024-01-24" version="1">MAVEITIDNSLGALFIGLIIASVLNGVTYSQAWFYFSAQSREHSDPQWLKLTVVTVVSIDLLHQLFTSQWLYYYCVTNFSNEAALNTIPWSYYGMGVPMGVNTVIVQTFYIWRVWKLSKSLILPGVLWSVCLAQFGLLLYYVYRVSGLTSAAEFSTVMGPYAIATNGTGTAADILIAAAMVYLLQQARSSIKRTNNVLRSVTIFTVTTGILTSVCAIFVLAMAAAYPGTNIEVTFYFILARLYSNSFLATLNVRDHMRDRSHSGGVITTSDFQVHPRTNHSAVLTTASHELDNFPRQKTQMDDRSGDLETVISVKVDRITDRDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNJ1</accession>
    <name>A0AA38NNJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_380131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793639">
        <property type="protein sequence ID" value="KAJ3780860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNJ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="220" mass="24211" checksum="D97F6E12885F4DBF" modified="2024-01-24" version="1">MTGQAYTLPELKTAIDFLLSDASTPLGNFNLGDRVSIPVTSSTASVPVKIESSDPTDTLRQEMSSLILLVNQLVSNQSRNPDSQSSISTAPKPKRECSCGFCGKTSCDAKSVRDCDEMKDWVSKGYLEKDANRFARMRGGISLPDEDRYKRGPLKARFELYWCKNPTAKTWMLEPVSPSMTAEYDGIQCSQHAAYTLRGYQGPDMLAKTAMACPGINESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNM6</accession>
    <name>A0AA38NNM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_431970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNM6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041378360" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="179" mass="19963" checksum="C5DC87B0DE5754BF" modified="2024-01-24" version="1">MRFGFASTMFTLATAIYAAPLDVGSSNEGGRLSRLSELESYSTWHNARADADPQVLLVSIRFNDANDEVAPSYRNMNLSIDRNSDPIRFRYNVPNPVQQRASTLIDSFARAKNLGPANVCPMNDFPFSGPDAKFSFTFRMNYVDCLTNFCWAEVKSDGSAVIKVGGRHGRQIYEYTPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNV3</accession>
    <name>A0AA38NNV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_277277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793542">
        <property type="protein sequence ID" value="KAJ3781595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNV3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28854" checksum="3D3E3DD7368A44E2" modified="2024-01-24" version="1">MAHIPVAIFVGGTSGIGRGMVEAFAHHVNGNTHIIIIGRNQAAANESIRSFPKPTESKADSTSPDNDLPIHEFISSDFSLISNVHETANTLLNRLTKVDYLVLTPGVSLFASRKETEEGLDEKMALSYYSRWTFIRDLLPLLRKSDIRGGARVYSVLSAGRGDLGSIQVDDLDLKKRHTIERCRLAVSTYTDLMMQKLAKEEPRIGFSHAFPGLVRSPMITSSRWWLTAAYYLFYPIFAFFSQTPEVNWTLVSFQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPB8</accession>
    <name>A0AA38NPB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_294898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793391">
        <property type="protein sequence ID" value="KAJ3784070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPB8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29750" checksum="9DB509E94D970E4E" modified="2024-01-24" version="1" fragment="single">MSFSTGNSASTTLYQLVTYLTRPLIEIYPAQTILQLQFFLHANLASQFLSPETFSLSPFTLLLTPGCLPPTPVYAACLQAGIAWPQWIRALGGKALYVFVMDGNLKVRIGEVDDAVTFWFAEPSESLAHLTSKMQTQISSDDDQSPMTLKLQATLDSVRSRSSPAAEPRKSALLTSSRLFNNTRNAVHDSDSESDTESTASSSLFSETSSIESMSSLSSTASSPTIDTTSHHHLSRSQRRLARSTVDKGKVDTCRYTYQGGQTLVMTGGVMLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQS0</accession>
    <name>A0AA38NQS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_343575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQS0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3789386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="23116" checksum="2295CD07355BA264" modified="2024-01-24" version="1">MLLPLWPAETDVHSQRLSPFDIPLIPVESRKYLLVFYKPLQMEKPSKDSTIYDSRLKILLAGFRAIARQVSYQDLQGTGVRLPEQGISVSGPLEDAFTQIPGLSDTTSETGAATSTTVPISTSASTSQLSVIASSYSRDAGLEFDPEALIELGLCRVLNSKENANATGNEPLSEGIHEEQIDTEQSVMVRLTPIGNAVMEMVWVGGLALSSFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQX1</accession>
    <name>A0AA38NQX1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_425596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793260">
        <property type="protein sequence ID" value="KAJ3789458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQX1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="3">
        <location>
            <begin position="64"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="527" mass="57180" checksum="587C713F15BAA4C8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRL2</accession>
    <name>A0AA38NRL2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_26194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRL2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="404"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="497"/>
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    </feature>
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            <begin position="92"/>
            <end position="503"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="27"/>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ3789806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="558" mass="62185" checksum="08B96473BF10AD2D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRX4</accession>
    <name>A0AA38NRX4_9AGAR</name>
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        <recommendedName>
            <fullName evidence="6">Protein SMG7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_282891</name>
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        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
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        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Est1-like_N"/>
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        <property type="entry name" value="Est1/Ebs1-like"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="60"/>
            <end position="209"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ3790027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NS04</accession>
    <name>A0AA38NS04_9AGAR</name>
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        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_383720</name>
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    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
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    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ3790009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
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        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
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        <property type="entry name" value="GroEL"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
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        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE"/>
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        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00064">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="215"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="1917"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="797"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1332"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1533"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1431"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1443"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1460"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1485"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1547"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1603"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1690"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1736"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1812"/>
            <end position="1823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3790009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="2281" mass="254616" checksum="4F1132A3A194FC83" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT32</accession>
    <name>A0AA38NT32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1748-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_339854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT32"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041378615" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="72" mass="8061" checksum="BF92A3354D9D08EA" modified="2024-01-24" version="1">MLGTLVHLGFDALLISAFLAGVKRTTGLTPALSQVPNKDIRQLLRSYLEIGEYTFDLAVVFFGRSSSFERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTB3</accession>
    <name>A0AA38NTB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_416236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793248">
        <property type="protein sequence ID" value="KAJ3790661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3790661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="285" mass="30709" checksum="E9A9AEFC0F676142" modified="2024-01-24" version="1">MSYSTPLEPSSSTASLLGLHKVMIEARNPRRPVVGSWLMFPGASLARMIAQMGYDFVLVDCEHGNIADADMHTSVGAIAAQGVSPVVRIPTPENWIVKRTLDSGAHGILCPMMSTVEEARKLVSYAKFPIPNAQRTPDSITGIRGVGSPFAPAAFGQGMGEYIATANRNTFIAVQIETVEGLENCEEIAKVDGIDMLFVGPNDLCSSMGYPALDHAKIPEVQAAIQRILSASKAAGKYAGMFCTSAEQIQARYEQGFDFMNLGADVVALAMWNADELRKLKEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTY1</accession>
    <name>A0AA38NTY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_406021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="32"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="127"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3791073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="358" mass="39328" checksum="8A8DE7915C26646F" modified="2024-01-24" version="1">MKILAILYNGFEHAEAEPRLHGTVENKLGIEEWLKSLGHEFIVSSNKEGPDSDFQKHIVDAEVLITTPFHPGYLTRDLVEKAKNLKICVTAGVGSDHIDLNAAVDHKIQVLEVSGSNVVSVAEHVIMSILLLVRNFVPAHEMIERGDWHVSEIARNAFDLEGKVVGTIGAGRIGYRVLQRLGPFDCKELLYYDYAPLPAASQQAVKARRVEDIKEFVSQCDVVTVNCPLHEGTKGLVNDELLSHFKKGAWLVNTARGAICDKDAVARALKSGQLSGYAGDVWDVQPAPKDHVWRTAKNPLGGGNGMVPHYSGSTIDAQARYANGVKSILEKYFNGQPQEPQNIIVGLGKYETKAYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUB2</accession>
    <name>A0AA38NUB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_338392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUB2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="518" mass="58417" checksum="4D1A224B22D2E650" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZC1</accession>
    <name>A0AA38TZC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rrn9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_431223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZC1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57965" checksum="916C86B5DEA28A43" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZR9</accession>
    <name>A0AA38TZR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_55271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZR9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="101" mass="10724" checksum="3FBE3FA7E2C4BD6E" modified="2024-01-24" version="1">MSSPSQETSSQETPSTTLGLLPAPSDAPTKKLDVLGSGQKTVLDELGPMVVNSDGTLSRIANWSNMTEAEQERTLRVLGSRNQLRLAARIDSAESDQGPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8E1</accession>
    <name>A0AA38K8E1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793523">
        <property type="protein sequence ID" value="KAJ3781809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8E1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="163"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="353" mass="40257" checksum="404C1204D27EB049" modified="2024-01-24" version="1">MIIQGLKSGPLPEAKQIEHFFLSSSHRSAYNIVQTKEREVLKNPLVNPSQQQREGYQDTLVNLRVIGYLFLFFPGPNHRALADVFSSVVSAEDTDLATLGEIYKKCFVRAFYKYRKTPAFIPSHPSRPSFDQRVDKIRETLYEAPKDYSDSKFKALIRDNFRCMISGVYEEEYQHQFPEDEVDTALSTEMAHVIPEGNYFGLDKPNKEKYAASILAVFDRFGFIIEKFDVHSLTNVMTMIQPIHNSFDRLRLWLESTDKLNEYKVVVVNRKHAFVPEKPITFKSTDPRLPLPDPQALELHAAACKVAHLSGAAEQFEKYSRDFESTYVLAEDGGSSAVLEHAFFKAGLIEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KBY1</accession>
    <name>A0AA38KBY1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_437693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793656">
        <property type="protein sequence ID" value="KAJ3780778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KBY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041281624" evidence="1">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="78"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="276" mass="30620" checksum="C60ED7BF19FBA6C2" modified="2024-01-24" version="1">MSASLTTAALFLSSSRHSLAAQMVISNYIQYSCARRQNFYQNLLSAYNDEPGMISPMNVCIRLTYKYWPTRDIIIMSHEGTEATQLRSVLIDLKVPQTTLDSDLFPDVPTPTTVPVHPVFEHEHSLTASGILSEVTRLMERKHTNNVTLVGHCLGRAMFYPLFFTLNLPTSANVHTVVFGASRVGNAEFAALIDSNARVRRFIGFEHPQGEIHLLGNDNAVSCPGDDDAFDLPCQTKTVCFLGLYQGVDIGTLFCAAARLKLTQLGTRMFFPVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCN8</accession>
    <name>A0AA38KCN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_382402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794759">
        <property type="protein sequence ID" value="KAJ3779501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCN8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="246" mass="28001" checksum="9EF78725629A9DF0" modified="2024-01-24" version="1" fragment="single">MTLHSMSDALECFHANKGIFIDLAIRSNFHIPKIHFMNHYVDSIKRAGTLDNFNTEYTERLHIDLAKDAYHATNKKDEISQMTIWLERKEKVMKHAAYIEWVKADKHPPLRSHWIPPGFNLTRTIKMAKHPSVYMVKISDVVQMYGATFFKAALARFVIQLQRPNLLGARLDDAASGLFLGVSHVSSYHRIKYICQDIFTGRSSTADSIHVQPSRKGNYGRTVPGRFDTVLVNVSDSSSVPLDISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCU9</accession>
    <name>A0AA38KCU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxisomal dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_297777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793471">
        <property type="protein sequence ID" value="KAJ3782518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCU9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="181"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="34074" checksum="E3FC2F35937544CE" modified="2024-01-24" version="1">MSPDISKAVGFELPDRPVTWLKRDLILYALGVGAKNTEDDFPCVYELNPNFAALPTYPVVLTFKGDSQELNTFADRMKGDRIPGMPQVDPNRIVHGAQSIEILKSLPLTSGPGWKWKTRYTGISENKTGVVLTAENTLVDPENVPYAKLYSSSFNIGMKITGNKFNQVIAGPPQAKPIPKGKKPDWIYRDDTSVHQALIFRLSGDYNPLHIDPAIGQAAGFGGVILHGLSTFGFAARALLKTVGGNKSDALKFFGVRFTSPVKPGDALETQIWKVGPGPNGTVEVTFITKNLKTGKDALGSGIAYIVEYPLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDJ7</accession>
    <name>A0AA38KDJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP synthase subunit H-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_368101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793618">
        <property type="protein sequence ID" value="KAJ3780986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDJ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="115" mass="12619" checksum="9F518C5714952BDD" modified="2024-01-24" version="1">MKTLLPDWPLTFYVRILRAAVVANELIYPTLLFTATTTTPSDLVMPSVLPVLFGLVIAVVLMACAAIFTPKGPQQVLIRTSLMLALAACYLMWMVTYLAQLHPLIAPTRSLKGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KDX7</accession>
    <name>A0AA38KDX7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidylethanolamine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793531">
        <property type="protein sequence ID" value="KAJ3781706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KDX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001858">
        <property type="entry name" value="Phosphatidylethanolamine-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01220">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="213" mass="23230" checksum="211C69F30525B83B" modified="2024-01-24" version="1">MALDPLSAVVTALKRESIIPDVIPETAGFAPTVLFSIIYRGVTEAVLSTEVLREDTLEEPEINFTPMVASDESAGDSTSKRGETSYTLVMTDPDAPSRADPKYRQFRHWVITGLKSPPTSQNPSGTASLTALKTRASITPYRPPGPPPGSGPHRYCFLLFQEPIGDSFSIPEGAKEYGAALEERRSWNAFEFGNQYGLKLVGANYFIVKSVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KE61</accession>
    <name>A0AA38KE61_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_19752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KE61"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041282876" evidence="1">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="163" mass="18300" checksum="5D90BBF9770FC995" modified="2024-01-24" version="1">MLFLVTASRLFTVLYLCVSMLTASGSPLPTSGELDIRLGLDILENEVVIHAVLAIGVTRVHASWTDKSHTQLRPKEIQDVIRSYDWTPLGKAKFKSSADHEQALQALLSIELPPYKETGGDCWDYVEAALETLEKRDELLDSASILKGFRIRRKSFVATNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFB3</accession>
    <name>A0AA38KFB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_377310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793402">
        <property type="protein sequence ID" value="KAJ3783836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1206" mass="133300" checksum="E44FE4C9A3840920" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFU4</accession>
    <name>A0AA38KFU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_152156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFU4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="247" mass="26845" checksum="2CF110EDC3E4580C" modified="2024-01-24" version="1">MSLTPPVIIASPLSSYTPPAVPRKRTTSFCCSSTSCSFTPNPRPTKVPRTAMGSLRRTESFLCLRDMQKKSTSTANATADRKQRERTKAKSMDYTAYVAAAKSSSSASSPSSLPPSPVFQRAASIPPIPPKPTQYSCTYRSSSPLSPHRTALPGRPIFPKSKAEPDLYKKAIITRMRCTPEGQRILHMGPKLAVSIMTATKELERIVAAQAPDDNDMAMSESSPILSNSWVVVSSTNQDWEMLDCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGN3</accession>
    <name>A0AA38KGN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_286052</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGN3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041384534" description="Mannosyl-oligosaccharide glucosidase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="25"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="291"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3788563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="802" mass="90864" checksum="D69EF17BECBA0630" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHK4</accession>
    <name>A0AA38KHK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_251517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHK4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17550" checksum="8A2E2121C58BE6E1" modified="2024-01-24" version="1" fragment="single">VPSDRLEQINAFVTDTSEDLQRYDRAVIEMERQLVAIQNARDDLRRRFDNAQSLIASPIRNLPLEALSEIFSWCCWRDESSYSLSLGKEGSISCPTLRLSWVCSWWRKCIQSSPDLWSSIEVTSSRIFHLNPSSIQLFRMYLSNSEKRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHQ4</accession>
    <name>A0AA38KHQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_286944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="134"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3788111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="535" mass="59021" checksum="61919BE949CABABA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KKF2</accession>
    <name>A0AA38KKF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793876">
        <property type="protein sequence ID" value="KAJ3780164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KKF2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="575" mass="65092" checksum="99FB8C6C165B6B53" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLI3</accession>
    <name>A0AA38KLI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_430183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793635">
        <property type="protein sequence ID" value="KAJ3780885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLI3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="192"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="317" mass="34942" checksum="0B7DD96760A7D7D1" modified="2024-01-24" version="1">MLLTFIPMSIASHFGNWDVALRFSVSFIATMNLTKFLNEATDSLSNQLDRKHTGLLNVSFGNAVKIVAAIAALLQGTYHFAILGSILTNILLILGWSFIVAGLKFSMSDFETTAAQASSSFMLLTCIILMMPTAHHALSNPYFMQGSALSEADTDSKEQWQDVLLKSVSRATAILTLVMYFVYLFFQVRYQLVASIEELCEKYYFPKSFISLILLPLANADNTSAMKMAMRGQMGVTVDICIGSAIQSIAFMEPLLVIVGWITGHEVHLFFGKFETIVFFSSVLLALTVVKNGKSNYLEGVVLVTLYLIIALACSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMF2</accession>
    <name>A0AA38KMF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_436824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793496">
        <property type="protein sequence ID" value="KAJ3782145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMF2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="860"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="766"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1126" mass="125573" checksum="60F01CB26D663F88" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN11</accession>
    <name>A0AA38KN11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_279660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793816">
        <property type="protein sequence ID" value="KAJ3780276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN11"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAG-pre-integrase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="66" mass="7418" checksum="DF65F1C97571E8C0" modified="2024-01-24" version="1">MGFVAKSRSLNRPANLRTWHRRLGHAGLTRIRMMIDKGLVDGLVVTGPVNEKLEKCDSCQLGQAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNI6</accession>
    <name>A0AA38KNI6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_34631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793386">
        <property type="protein sequence ID" value="KAJ3784214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNI6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="595" mass="64565" checksum="F6E8651ED630D8E5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNX7</accession>
    <name>A0AA38KNX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_333776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="MU793370">
        <property type="protein sequence ID" value="KAJ3784604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="9">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3784604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="277" mass="31068" checksum="A4D10D1383B58176" modified="2024-01-24" version="1">MSSSLPPLSLSILGVEPLDEFIKEIADFVHHMIVTRPDLPGNVEVEAKIGLLRDRGGGRMFLPVLVETILAPDSIDCRFESNMTAAQHKHFNTLLNKLKISSSQPGYASSSPLDYHHLHLVDAFYPSESNDREKIRVTRDEKTGTVTESMKKIRLGDLNIYSPKRMADWRVSVNLEVPAPHPVGSSTHTRKKDRMSYSHEEFNIDLTQVTSTNPSGTPEILHELEIEIARPALLLSTAAKRGDMNASEHERDAFDELIRAFVNNARILVRNASDGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP92</accession>
    <name>A0AA38KP92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_356197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793357">
        <property type="protein sequence ID" value="KAJ3784964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP92"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20996" checksum="47779D06E8C3230B" modified="2024-01-24" version="1">MSSVWGTSTPPPVSSAVFAISGSATISAPPEKVWQVLFDFDSYKQWNPFVRSQEILNKPDSAPLSVGHRIKLFPVHLPPTMDDGNVGFLQKNSTLVEVTVLDHENHRVAWRLANGLPRWMLDAERWQMITAEEDGGSEGGEMKCKYESYEVFRGILGYIVQWFVGKELKLGVDAMAEELKRRSERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQI4</accession>
    <name>A0AA38KQI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RF-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_167077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793310">
        <property type="protein sequence ID" value="KAJ3786584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQI4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="149"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3786584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="254" mass="28594" checksum="1B26AB9CEA11D7E5" modified="2024-01-24" version="1">MSIPVELRASARSAYRSLYRASSSIFGGDTPVLTAFRSKMREDALAAQSESDPSVYEQYATHARDVAQFLRRNVVKATKLPGNETWSIRITEDTELGDNDSVKNPSPISSNSTAAHTGNAALAHNKSLPDRPMYYSALKRASNQRKIPELREKDIEESFVRGSGPGGQSVNKTENNVQLLHKPTGIRVSCQETRSLSTNRMLARRLLTAKLDALENPGLSKEELKRAKQRERERRRRKKAKKKMEKKQVELQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQU6</accession>
    <name>A0AA38KQU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_265901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3786989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQU6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="442" mass="49133" checksum="ECCDBA613C321FB1" modified="2024-01-24" version="1">MVHSRFNEKETNPNPHINFITPLPAENSHDAREYLRALAAQVRPVMKAHAFTVNSLEEYEHNAVFAGRNWNNGETVELVLRRPSGSFLPSSWLMSTLCHELAHNKHMNHGPAFQALWRRLRNEVRQLQNKGYYGDGYWSAGTRLADSAVISGEGLDMSDLPEYICGGAQSRTRPSNLRQRRGPRRSREMVASNKTGRQTAKQRKAGSRVTSKYAFQGEGISLGAIDTGKGFGKQASSKRAREERVLAVERRMQSLASSSSVTVPLVSTAASTSYAEYSEDAQIIIETNADRKKTLLDAELDSDEDLEKLGSGAVWKDFENDFTFTGHGRPNVIVISSDDESDSATILEGKGKRKADVFEQMIEPSPKIRKKSDLNIGLGKIVETEVTFRKKEALGMTGKGRTIGDGAICTGEHTPWYCLVCTLENEPYHLVCAACRTEKRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR03</accession>
    <name>A0AA38KR03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_417029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR03"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="132"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="600" mass="66833" checksum="64E031F4E2C6F8CF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KR94</accession>
    <name>A0AA38KR94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">APC amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_288238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793291">
        <property type="protein sequence ID" value="KAJ3787499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KR94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="522" mass="56274" checksum="6458BB67AB25678F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KRB3</accession>
    <name>A0AA38KRB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_33205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793383">
        <property type="protein sequence ID" value="KAJ3784266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KRB3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="24542" checksum="0832D3BE2199BC2C" modified="2024-01-24" version="1">MFVPYCEQAKLMFPTSTQWLSDTITKVNSQRGGISYAIRKEVWMENDQMKETDKQTMVKHCVPWIRISRQLVYNLRTEGDQGKGMTRADSIGYLNWLMDKLGMDENMQIKLKRPTSPPENDQLSYDEWFSWAMDTICDWPKNLFQGPSAGDGGGTRVDLPAQVGTTPALKQRVQEAREELAMYIKGLSVEPNIGDDPPKTYEIYVPGPEEYYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT31</accession>
    <name>A0AA38KT31_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_279977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793951">
        <property type="protein sequence ID" value="KAJ3780057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT31"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="141" mass="16643" checksum="1EDAE62B123C54E2" modified="2024-01-24" version="1">MVQFAWNTGNAELKEYWEYALKALNILQHDGMSDEEDVEEDITVDGVATKRLVRIVKILGYRHESFRGLFKIIDATRGLEDLIFNQSGRSRIPRKRVNIVDLREPPKDLPKSVFRQEYLNQLSEFDIEELRISEQDFEIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT80</accession>
    <name>A0AA38KT80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_279718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793837">
        <property type="protein sequence ID" value="KAJ3780237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="161" mass="18228" checksum="F1B405A0E9E8B265" modified="2024-01-24" version="1" fragment="single">MVGKRFVVHGPREQRKEGGSTQTNPAETPNEIEPSSGQPEPTENAANPAIEVPEVSTNTSLLTALAASQSKLDLESLLKNQYGNDTMFKKIIEKPKEYRNFEVSNGLVYLIQHDRKVLCIPRLTVNKRNIRECIINEAHSLLAHLGPKKTSDYLRDYVWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTB1</accession>
    <name>A0AA38KTB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_374635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793307">
        <property type="protein sequence ID" value="KAJ3786741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTB1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="500" mass="54643" checksum="33D08BD9F4321FD4" modified="2024-01-24" version="1">MATVFTHEFNTPVYKGKTSFNTGLYINGKFVEGSDKTTIDVTNPATGKVIAKIAEATAKDVDIAVTAAHKAFETTWGLNAGGAERSRLLLKLALLMEEHQQELAAIEALDNGKTFTWAMDLDTTFAIDTIRYYAGWADKIHGQVQETDEKKLSYTRHEPIGVVGQIIPWNFPLLMMSWKLGPALATGNCVVLKPSEFTPLTAIRMCELIDRAGFPPGTVNLVTGYGNTVGAAISSHMKIDKVAFTGSTLVGRKIMEAAAKSNLKDITLELGGKSPNIIFNDADLEQAVNWAAHGIYWNHGQACSAGSRIFVQSGIYDEFLEKFTEKSRSLKVGDPFDVDSYQGPQVSKNQYDRIMDYIQSGKDQGATVHLGGDRNGTEGYYINPTIFTNTTPDMKIVQEEIFGPVGVVIKFEDEDDVIRQANDTVFGLAAAVFSQNINRALNTAHRLKAGTAWVNCVNQLHANVPFGGFKQSGIGRELGEYALHNYTAVKSVQVNLGHVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KTX7</accession>
    <name>A0AA38KTX7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_264295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KTX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3787731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="498" mass="53425" checksum="5A797D648BCFF0DA" modified="2024-01-24" version="1">MSSVVKNIENIELALRTPLPASSSTLHLPNSDSVSVVVSFNGSNRDAAPLDGSQSSLPPVDGGFGAWSFLTAAFFVQAIVWGFPVSFGVFLDAYLNDTRYTSQPKASSLLPLIGPVSSGIIYCSGPFITPVITRYPYHKRTSLYIGTILCWVSLFAASYTSQVIQLVVFQGVLYAIGGSLLYIPCISYLSEWFNHRRGLANGLVFAGTGVGGILLPLILPPMLSSYGPPKTLRILSIAIALLVVPLLPFIKGRLPESRNRAMGPTPRGRGNVEWKKSVSFWVLVVANTFQGFGYFVPIVWLPTFASDLNLSSTSSSVALALLNCGSVISRLATGYLSDKVNPWLLGFSTLASTSAVTFILWGLLSYNLAGLLSFGLAYGILAGGWSSSWNGFTKPLSASDPNLSTTLFGILLFSRGMGNIFSTPISSALTSLKNNSTTSPHGFNHSAHLGFDVGGGRFEKMIMYVGICFASAALITLVGWVTDVARRRRALRRQGVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUI5</accession>
    <name>A0AA38KUI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_285738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793271">
        <property type="protein sequence ID" value="KAJ3788691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUI5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF5">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="169"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3788691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="886" mass="99086" checksum="1E1B984452CE91A4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUP5</accession>
    <name>A0AA38KUP5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_275524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUP5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="420" mass="44702" checksum="CF39438C8F191DE8" modified="2024-01-24" version="1">MQALRESQAAQAGSNFTTVVGGSDFDEEYLTNVTFGEQDFLLIVDTGSSDTWAPQIGFACFDLDNDPVPQSQCAFGTSGYDTNASTTFVADPDTNFNIEYGDGEFLTGTVGFDTVTVANMVVTNQEIGVVTNAAWEGDGFDTGLMGLASPNLTSVFKGTNPDDDEFPQTQIPYNPVFYSAVQQGVVSNPFFSVALDRGSFAAQNSSDLDQNLGFIAFGGIAPVDVTDTAVTVPVQGYNAASFLPENGSSVTYFYYTVDVESMSFTGNDKVFGTTNNIILDTGTTLDYVPTQVADAFAAAFDPPAVKNEDFGVYEVVCSATVPEFTVDIGGVTFTVDPADNLLPLGIQDDEGNDLCASGTFDGGPAEEGNIFILGDTFLHNVVVTFNIETDEVTLTQRTPYTNGGTGARRRSPESLRRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUR4</accession>
    <name>A0AA38KUR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial tricarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_344613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793266">
        <property type="protein sequence ID" value="KAJ3789051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="100"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="197"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3789051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="289" mass="31363" checksum="F3EF2619E45BAAEA" modified="2024-01-24" version="1">MVFAKEKPVHSLIAGTTAGALEAFITYPTEFVKTRSQFQGKNLAPLEIVRETLKTKGVIGLYSGCTALVLGNAIKAGVRFISYDHFKSVLADAEGKVSAPRSLVAGLGAGMVEAIFAVTPSETIKTKLIDDANRPKPQYRGLVHGTVTIVRQEGLAGIYRGLLPVMMRQGANSAVRFTTYSTLKQFVQGTARPGQTLPSAITFGIGAIAGLVTVYTTMPLDVIKTRMQSLSARSQYRNSFHCAYRIFTEEGVRRFWTGTTPRLVRLVMSGGIVFTVYENVMSVLKAIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUZ2</accession>
    <name>A0AA38KUZ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_362216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="MU793442">
        <property type="protein sequence ID" value="KAJ3782997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUZ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3782997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="251" mass="27204" checksum="9EFBB0D6E2A451C8" modified="2024-01-24" version="1">MARQFFVGGNFKMNPVTRKDKVALVKLLNEAELDPATEVVVSPPALYLIPVKESIRKDIKVAAQNCYFKDSGAFTGEISPGQLVDSDIPYVILGHSERRTLFHESSEVVAQKTRAALDKGLSIILCIGETLKEREAGETAKVCEEQLKAVVNVLKESDWGKIVVAYEPVWAIGTGKVATPQQAQEAHKDIRSYLSKAVSSAVAESTRIIYGGSVNAANCKELSTLPDVDGFLVGGASLKPEFVQIVNSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVA2</accession>
    <name>A0AA38KVA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_46261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793407">
        <property type="protein sequence ID" value="KAJ3783702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVA2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="631" mass="69975" checksum="881EE9316C7849FC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXD5</accession>
    <name>A0AA38KXD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793517">
        <property type="protein sequence ID" value="KAJ3781868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXD5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42936" checksum="669D65DB352DCFFB" modified="2024-01-24" version="1">MDHDQAFFALPQYLQRRIDSAYFSAVKHAHVTNSHRDAGTLRSSSVEPPPKRRKTSVHELSADSGGGFIVEDPSDVATTESTTVGGGGFILNDPDSTVAASGGGEGGHIIDGEMPISTGDGFIREVNEVNGNSALQSTSEILPPWIPFSSIPTALQLLDLPPDDEQVLGIFRNAASGWDNRDRIDDNLEVTQADWRAVCTILLEPRSGAGDDNIEVENQIRPGDLEEDDEYVQDLSEVDLDLNSDDGADSDDNYDPGPSSTSKFKTKSSRRPARTELVGSMSGGQRRTRVSRLRSDGSDFDPFDEEGSSSGTGRLTSRQKATCIEAFGLFFPDAKDDLGQRRLMLSDIQRVTKLLGEKLKAEEMLEMLEVFSTAPDRSMGLQDFERMMIAAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXE3</accession>
    <name>A0AA38KXE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_244353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793290">
        <property type="protein sequence ID" value="KAJ3787512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXE3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="110" mass="12555" checksum="2CD749F807244F8E" modified="2024-01-24" version="1" fragment="single">KFEESEKKPGTQMGTKGSKGKRECYNCGRKGHIKDDCYRKGGGKEGQYPAWWRGRKDSPFKPYSSANMAVNNSIQHYAMVAIDHQEQGTIYADSATSEHFFRNRSDFLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXN4</accession>
    <name>A0AA38KXN4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS Git1p-like glycerophosphoinositol permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_298165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793487">
        <property type="protein sequence ID" value="KAJ3782273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXN4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3782273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="498" mass="53118" checksum="A9919E15493A9914" modified="2024-01-24" version="1">MANSTLSYSQNPLANRSPLVVSAEEHAIKVRREARSMSKKEKVSSIFTIAAAGLGLISDGYQNNLMTMANVVFKNIYGTEYSSTVSTRVSNALLVGAVLGQIFVGLICDRVGRKVALFATTALIVVGATLATAAHASTPAGLFWFLTVARGITGVGVGGEYPAGSTSASEAANERSPKTRGPVFIMVTNFVLSFGGPLAVSVFLVVLSAAGENHLQTVWRVCFGIGIILPLGVFVVRMRMMSTILYKKGAIKRNVPYGLVAKRYWKSLIGTCFAWFLYDFVTFPNGVFSATIIASVIKDSDIKKTAEWQLLLGVIALPGIFIGAWLCNVIGRKNTLMLGFSGYLVFGLIIGCAYDKITKIVPLFVVFYGLMQSSGNMGPGDMMGLVSVESYPTAVRGTCYGISAALGKVGAAVGTQAFTPIETNLGKKWTFIVAAICGVVGVLVTYFFIPDMTGIDLADEDAKFMEYLAANGWQGSVGEEIDAELIVSAERSSLDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXS9</accession>
    <name>A0AA38KXS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_80159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793474">
        <property type="protein sequence ID" value="KAJ3782468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXS9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="850" mass="96317" checksum="0E5C562D88C18C1D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXY1</accession>
    <name>A0AA38KXY1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_363150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793461">
        <property type="protein sequence ID" value="KAJ3782663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXY1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="410" mass="45732" checksum="1D55B40FCF29229F" modified="2024-01-24" version="1">MVSDEDSNAIALKQWIARNGGYFNLDTRFSKTYSGFSVIAKEPLPFDSTIVTIPFRLAITRKNAMEALAQILKAPSALDSWNERQCIASYLCFHHILNGESLYLQHYHYVQTLPTPEQLRTGLFLTLEERELFQGTNMYGAIRDREQEWRSEWSRCHAIVAGVNVEWADAFTWKLYLASASHMSSRAFPSTLLSRTPSLVSSPSTEPILLPGIDSLNHARGQPVSWAVTYPDEFDNVSEPCVSLILHSPTSAGSELFNNYGAKPNSELILGYGFSLAENPDDTIILKVGGSDADTKKWEIGRSARGVEGLWAEILSLVGQTSAEEETSYEDELDASSMLGEMVRVLIEKLPRPGRSLDPGRIRPEVIEMFRTYIEGQRDILDSLLAFADAKERTAIEKARSEGVDIVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYN7</accession>
    <name>A0AA38KYN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_359496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793398">
        <property type="protein sequence ID" value="KAJ3783908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYN7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="417" mass="45691" checksum="5EC3E8C0FC728CDA" modified="2024-01-24" version="1">MSNVKAPAPIHLLRSHTSSIAVLFISRDNECVYSGDASGYAVSTSTRTLRAIASWKAHEDGFLGIEEWENTIITHGRDNKLHVWNRPDETSITSGIGSSAALPGLSTPVLWFSMDVNALNYCRFSLLPASFIGSTSLSESLPSASTSKVDSASECTALIALPNLIESSEADVWSIPSCKRLHAAIGKHAKTTIFYGDGRAGENPTGIIMSLHLFETASSSKSTPELRILISYENGNVALRRYANPEKSMSVEGKGWEVIWETALHREAIMAMQVSSNNQFALTVSADHIIGRYDLTASTPDASTIHRTKHPGNACIAIRDDGRVCAVGGWDGKIRLYSTSSLKPLGTLKYHKDGCQALSFATMIRIDPGSRYKEQDQDADEDEDMLNEEKFQRGRWLMSGGKDKRIAIWELISFEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZG7</accession>
    <name>A0AA38KZG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_240162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793338">
        <property type="protein sequence ID" value="KAJ3785573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3785573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="120" mass="13520" checksum="9BDA12C5B4BFA653" modified="2024-01-24" version="1" fragment="single">LTRLENLEKQMSASANTVRFPEKKCKNCQRTGHVAEECFRKGGGKEGQFPSWWKGKREAAERPSSANATMTSDEKNPEVAQLTQFYGLAATSLDKTSDEIYADTGASDHFFRKREDFATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L004</accession>
    <name>A0AA38L004_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_160404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793303">
        <property type="protein sequence ID" value="KAJ3786893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L004"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="411" mass="46161" checksum="A3FF7DE5D1754FAC" modified="2024-01-24" version="1">MHFRHSKEPEPSVDAGTPVLTVESSLEITTTTRQEWISSNCTGNKRALLIGINYSESESSLDGCHSDVSRMYKFITQTYGFSEENIVVLKDDNKLEDEFQPTKANIVHSFIVLCVLHSDCSLTQLYWMQWLVKDAQTHDSLFFHYSGHGGQRTDRDGDEIDYNDECIYPVDSIPVTDASDEQIQATRHKVLIDDELHLHLVSPLPVGARLTAIFDSCHSGSVLDLPFMYSAASGRLKEGEFLAEQDAEKAGEMRKGRGVLALEKTEKWKIKEKVFEMKDVLEATKDILHETGEKLFVEKDAKGALMDFERLDGVKAHVKQVEQLEKRNESLADIVLISGCKDTQTSADASEDGVPTGALSWALMSTLKENSEPTYLQLLDGIREKLKRERYDQLPQLSTGHPMDLSAIFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1M2</accession>
    <name>A0AA38L1M2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_381358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793989">
        <property type="protein sequence ID" value="KAJ3780007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1M2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="201" mass="21792" checksum="7F5F2DBD2A2A935C" modified="2024-01-24" version="1">MSSIYSYLNPAPLQRNTVQSNDRAFHSASVGQANPVFSTTFHESNSSTQGTNLGSFTASSYSPLRSFDSHQMTPSPTTGSRLYLQPTGNTPSPTSSDTPSPTSSDTPSPTNSDTPHGTLPATTRASAKNLEQYAITLSRTFHLSAEYQMELITDPGQRFLFQVANNFAVRTAIERLQPADSAVPITRSLEVRVLRLAYADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1Z4</accession>
    <name>A0AA38L1Z4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">GGU10DRAFT_336730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MU793618">
        <property type="protein sequence ID" value="KAJ3780982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1Z4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="62"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="252" mass="28188" checksum="ABFE376E3A804E46" modified="2024-01-24" version="1">MNGTEFESSKLGSKEHWDSVYARELASFQEIGDEGEIWFGQESIDKIVQWASQYVPPCDHPTILELGSGNGTLLFFLVEEDYSPKRLCGIDYSSAAVELARSIAHQRGAQDILFHTCDFLLQDPPFISEEQERSGRMDNWDLLLDKGTYDAMALGEKDALGRSPVFLYPSRAARLIKPGGFFLITCEALSFNQKLQTPTSTACNFTEEELKTNFVTQESGLVYHSSIKYPTFTFGGHSGTKYSSLAFQKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2B0</accession>
    <name>A0AA38L2B0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_97537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793530">
        <property type="protein sequence ID" value="KAJ3781717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2B0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3781717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17904" checksum="A87CF5F50B1A5EA3" modified="2024-01-24" version="1">MVMLLLSIKAELENVSDLAPEDDDFEYFFQVKCTSCNEIHSKHVSLNRREEYDVSGGKGGKAHFVWKCGLCKRESSAKFDATSPPKPYNAENGQLAPFLKIECRGLEFIGFDPRGMWKCVGTKGTSFSEVDLSEEEWTDYDEKAALPVGVSEFGSAWSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2T0</accession>
    <name>A0AA38L2T0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_239924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793719">
        <property type="protein sequence ID" value="KAJ3780505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2T0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="67" mass="7589" checksum="12EF76A48F757F5E" modified="2024-01-24" version="1" fragment="single">ERFQRSADTISRCIHRISNMLVQNPFYSAHIQNPAKKTAREIGSNPKLYPYFRHAVGAINGSHIAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L365</accession>
    <name>A0AA38L365_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_436168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793436">
        <property type="protein sequence ID" value="KAJ3783112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L365"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="398" mass="44760" checksum="3D756DF5426D8F96" modified="2024-01-24" version="1">MQNSWPSSPPLTSPHSLSAPDGFVRPPPPSKMHVKRVTLTSKKNWWMVEMDEDKESKPSASTTEAIVDPFLYSDYVQHEIKREHTKTPPPPTPTMPPMDYRIPRHPNAIFSFPTPTPYSAPSGNPTATLAPCANGSASELFKCIVKKPDVVQMEINDEMQSNASDVTVQFLAELRVYTTVQTHRNICTFLGSLENIGMVLEYIDGRTLFDVISVRPELTTRAKIDYHNQLLDGLTHLHSYGLSHGDLSLLNIQVTNSSDTIKLLDFGRSVSADSVYANPEAEPMDPFTLLAKRTSIFSPLPPSKTEQIHPGTRPFCAPEILRGECQDARLADAYSFGLIIVCLDRCETVDLKPWDQRKDLLPKDLFEGCSVFADRARAYLQKWNARRMLIKEDRMLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3Q7</accession>
    <name>A0AA38L3Q7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_37552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1175"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="467"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1291"/>
            <end position="1520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3784057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1622" mass="176799" checksum="6CFA0F70FBC9A24F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L3S5</accession>
    <name>A0AA38L3S5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_364369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793492">
        <property type="protein sequence ID" value="KAJ3782200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L3S5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="62"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="34019" checksum="0DC5B9BA1EA4E039" modified="2024-01-24" version="1">MGSGTDSEKYLGLNENFAVGAKVATIVMPVPTSSFANIQRGKTRTILPTFSSLEAERVYRKEHLALVFRILHRFGFAEGVAGHCSVRDPVQPDKFWVNPQGKSFARMRQSDLIQCRVEDGEIVEGELPVDASATSIHSQMYKAAGRGIGQEGGSEGGVESLVHVHSPYTKAFSALNRTLDMISQDACAFYNQQALVPFAGGVFDNQEGARIASFIGPHDKVAILQNHGLLSVGRLSIDEAAWWQINFEMCAKAQILADSALRPGEKFVFAQEQNILDTREEIGSPEMGWFCLAAYVEEEEWHSKGEHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4S8</accession>
    <name>A0AA38L4S8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_181753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4S8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3786037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="331" mass="38057" checksum="1ABF9645D509168A" modified="2024-01-24" version="1">MADSATEIDLDSVIDRLLEVRGNRPGKPVQLQEYEIKYLCTKAREIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRHLVTLFSAPNYCGEFDNAGAMMSVDETLLCSFQILKPAEKKAKYPYGGMNMGRPVTPPRKQKKKDSKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L594</accession>
    <name>A0AA38L594_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_157010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793302">
        <property type="protein sequence ID" value="KAJ3786937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L594"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="431"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3786937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="528" mass="59911" checksum="02CFFA902D3A48C7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5D1</accession>
    <name>A0AA38L5D1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_426991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5D1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="426"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="894"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="962" mass="106011" checksum="168123ED6B6C47BE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5V5</accession>
    <name>A0AA38L5V5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_181589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793325">
        <property type="protein sequence ID" value="KAJ3786025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5V5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27964" checksum="19D0291371F42095" modified="2024-01-24" version="1">MIPEISLQDHLFHVWPPVPQSLGGQVDNILKILEDNGTIDIPNDRWVAFPADPAQATGQEGAVFQGLTTIFNAVIAAAQQIDSSLEHTFDFIVNGNVAMYSDRGVSSRPDGFNKVYTKTREKGKSEQKQVGTGDVVTQNAGGKPPKNERYLVYDLANPHQFKLGDAEKDENDDFAKLVYDMEQILALDPCRRFTFGTTIENCITRLWFLSHATLLRTKPFDFMKDHHVVPTFTRTTDSYFSIELALKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5V6</accession>
    <name>A0AA38L5V6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GGU10DRAFT_263698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793281">
        <property type="protein sequence ID" value="KAJ3788032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5V6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3788032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="463" mass="52661" checksum="CD9BA545B7E1FFD9" modified="2024-01-24" version="1">MSTPNLSVPRIAPLVLQSKKALQEGEQLCSKANELSTASAQASVDVLILDAKVRWVTDNVLEQLKLAACVAKSIEDKRTKLSKQMQDWDNLRTKQTKALDRVLDDLGSQRVPPDFHQTSAASSIFGSQDSEDEQEQASGLAAVSRSPSDTIKVPKPKPQTDRKNWKTLRDFVDDQAIEDIFEGMEEEHTIVEDILSRTDEYSEKLNAAIRSIREYLPENTPSPSIEQLITSQDSSQVSMATHLESLAAHYDQMGNALRESEAGDVFSQDDLQDMDRDTEELPSILSELEENLHSISATHKQFCQFRVTNQDHLKRLADVLEELDELGDIMSEMLQTQEAVESECENHFTEMQRHLLTVEHLQQRFVSYQTAFRKLILEIARRRVYKEAAESIVRGMMDQLTAMTEEERQVREHFNHEHGAHLPEDLCLCISNLPTKWEILPWAGEILETLPEIPADMVTEVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5Z0</accession>
    <name>A0AA38L5Z0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Arginase</fullName>
            <ecNumber evidence="2 10">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_307511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 10"/>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5Z0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3788227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="357" mass="37996" checksum="F0577D7C8B965458" modified="2024-01-24" version="1">MSSEIIPQFLKAPKTASIVGCPFSGGQPKLGVDKGPIHLVEAGLVNQLEELGWNVKFDGHHQFEDIKFTLSSSSVDSAAPTASSADNDTSTSNHWDPPIGILKNPRLVSRVCEEVAKVVSGHAKKGELPVTLGGDHSLAMGTISGTLDAHPEAGVIWVDAHADINTAATTESGNIHGMPVSFLMGLDGNQQAFSNFNPSPSSQTPFAWIKPVLKPSSIVYIGLRDVDAGEKKILKQNGIKAFSMHDVDRYGIGKVVEMALDHLNANNANPDKLRPIHLSFDVDALDPSVAPSTGTPVRGGLTFREGHYICERIWETGALVGLDLMEVNPSLEDDISVKQTVAVGCSLVRSALGETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC79</accession>
    <name>A0AA38NC79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_317439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793438">
        <property type="protein sequence ID" value="KAJ3783061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC79"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041346488" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="255" mass="26047" checksum="084CD38D7368C2AE" modified="2024-01-24" version="1">MYHFIVKALAFASVTLDALTAVQATLYVIQPAAGSTCSGGSPCTVQWLDDGTSPLNSEIGVTTCALYTGDMQLVQTVPPVDVSTTQSLTFTPIPNAGPDSSDYYIAFTSTNLEINGTKYISYSSFFSLNNMNGSFFSPVASATSSIALPSSLAGSSTFSETTVLSTITVGTITTSLLPTSTLSETASSSRFSTLVSSSASTTSSNSASISSGTSVSSSTSSSSATGLSSSNSAVSLRKASLPLIGFLSFTVLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NC80</accession>
    <name>A0AA38NC80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GGU10DRAFT_361966</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="MU793438">
        <property type="protein sequence ID" value="KAJ3783076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NC80"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3783076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="189" mass="21149" checksum="6AE372D98C594329" modified="2024-01-24" version="1">MFTEELKAFRRLGVRHVLLQVLNFASVIASGLMIWKGLGLITNTESPIVVVLSGSMEPAFYRGDLLFLTNPPLERYHTGDITVYKIPGADIPIVHRVMETHDVSSPIKISGLDLKVPGEQLILTKGDNNHIDDIELYQGLDWLERKHIVGKVRGFLPYVGYVTIAMNDFPQLKYALLGVLGLLALIQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCL2</accession>
    <name>A0AA38NCL2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_271539</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="MU793377">
        <property type="protein sequence ID" value="KAJ3784426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCL2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="846"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="789"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3784426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="913" mass="102008" checksum="FF151F8BD540BB3F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCQ4</accession>
    <name>A0AA38NCQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_270811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793365">
        <property type="protein sequence ID" value="KAJ3784741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCQ4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3784741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="65323" checksum="6BC6FB135E8A6ABE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCR4</accession>
    <name>A0AA38NCR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GGU10DRAFT_19541</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCR4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="640"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="965"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3784801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113135" checksum="FFD34000A4F8A6A4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38ND27</accession>
    <name>A0AA38ND27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_387181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793331">
        <property type="protein sequence ID" value="KAJ3785821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38ND27"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="9">
        <location>
            <begin position="157"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="452" mass="51861" checksum="E08FE0163C9897A6" modified="2024-01-24" version="1">MPRTRKSVTAILVFFVACFVFLGFLYPASDSFRSANFQHSTDVAAFRSDDKNLSTNYKSTSIPRGAHAYGFTIFDNLYLRNGTLFVVSSDLSKFPLRETILSAPLELDLPPDILMPRDEHMRFIDPEEGKDLLGSDFIYIEDTTVIVYENPTFMRHYYHWWGEIILGFWRVYQCARVSTPLPFPKRFLLPFVDGGKWRDDPGINGPLMRAVQPAISIETSDQWKDFYDLDRTIVFSRVAIINRPAAHRYPLSHKYNKMITSTLELHPDNAFWEPLQTTLLQNLLGLEFSFSSSRALSNDIKPVVTYISRQGGRRSLADQDHEELVHTLSELQKEGLCQLEIPKMQELSLKEQIELASKTTIMIGVHGNGLTHQLWMPSTPRSTVIEIFIPEGYLFDYEFLSRNVGHRHYAVWNDTYITTAPEKQNAPPNFQGKNIPVHGPTVAEIIRHRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NHJ1</accession>
    <name>A0AA38NHJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formin homology 2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_132919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793645">
        <property type="protein sequence ID" value="KAJ3780842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
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    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
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    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
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    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="357"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="1260"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="914"/>
            <end position="1042"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1186"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1230"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1508" mass="167644" checksum="94BAE5BE3B4E1C9A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NI17</accession>
    <name>A0AA38NI17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Utp14-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_318218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAJ3782642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="845"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="739"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="885"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3782642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118569" checksum="5A514921CD6AB1C5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ33</accession>
    <name>A0AA38NJ33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_231853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793655">
        <property type="protein sequence ID" value="KAJ3780783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ33"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3780783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="86" mass="9350" checksum="9659AE8887EE5EAB" modified="2024-01-24" version="1" fragment="single">FTPDREALVNYTNIEPEPIRAADGRIFTAVGRGDMVVALPNGNDKSTTVTLKDVLYSPNMSYTLISVIKLDRAGFSLLIEDGTCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKX5</accession>
    <name>A0AA38NKX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_56992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793426">
        <property type="protein sequence ID" value="KAJ3783304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKX5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="145" mass="16000" checksum="098FE5F41F1EE5A1" modified="2024-01-24" version="1">MECGICLHPKPMPNKSNAEVACNAHVHLDEALLLPLLPVMVETTDVVGVEHNPSQWFANASSFQLHQPTFNYNVSTSQPGSVPGPSTALSPSSANRSTRTQFPNESELYSRLLLLRRRGYPLWIPAPSQPIPEEFKKQGIRIGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKY9</accession>
    <name>A0AA38NKY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_347395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793282">
        <property type="protein sequence ID" value="KAJ3787997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKY9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="50"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="441" mass="48457" checksum="0B1C4163C75DBDF1" modified="2024-01-24" version="1">MLRVAACRAAPAVFASSSSILPRFSISRAARPAVNFVARRGYAEIYNRTKPHMNVGTIGHVDHGKTTLTAAITKVLAETGGATFTDYAQIDKAPEEKARGITINSSHVEYETDSRHYGHIDCPGHADYIKNMITGAAQMDGAIIVVSATDGQMPQTREHLLLARQVGIRKLVVFINKVDMINDPEMLELVDMEIRDLLSTYNFDGENTPIVMGSALAALEGRDKEIGVDKILELVKACDTWLDLPARDLDKPFLMPIEDVFSISGRGTVATGRVERGTALKGKEVEILGLGSSFKTTLTGIEMFHKELERAEAGDNMGALLRSTRRDQVRRGQVLIEPGSMKAVKKFRSQVYILTKDEGGRYTPFMQGYRPQLYLRTADVTVTLNFAEGTPDAEEKMAMPGDNVELDCELIFDLAVEVGSRFTLREANKTIGTGVVTKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL23</accession>
    <name>A0AA38NL23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_360588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793415">
        <property type="protein sequence ID" value="KAJ3783529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL23"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3783529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="363" mass="40248" checksum="891DEA27B9E9AA26" modified="2024-01-24" version="1">MHAIQQQYWSIRDYLSPVLKESKFKEHGRITPEEFVAAGDFLAYKFPVWTWEKGDSSKARDYLPADKQYLVTRGVPCLRRATSLAYTDADEDAERLLNFGDSSAGGDGDEWVETHAGRKPNLDSAANPGEIADIPDDSQDDDLASGVGNMSLGNVPAMSEIPDMDEIPDMEEEDLEEGDAATAAPKNVMDSSQVVEVATGNLLQVRTYDVMITYDKYYQTPRIWLLGYDENRTPLTPSQIFQDVSADHALKTVTIEPFPHSSSLQAASVHPCKHASVMKKVIERMNNSVVAEQLAQQKAPKEKKKWPFSRKASGIGKDDKNVAPAAGDDEEVEGMRVDFYLVVFLKFIASIVPTIEVDSTTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL38</accession>
    <name>A0AA38NL38_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_388983</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793412">
        <property type="protein sequence ID" value="KAJ3783604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="8"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="13">
        <location>
            <begin position="512"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="1488"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="682"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3783604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1589" mass="177667" checksum="728B514C45816764" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLE0</accession>
    <name>A0AA38NLE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pyranose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_435186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793373">
        <property type="protein sequence ID" value="KAJ3784533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLE0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041382746" evidence="10">
        <location>
            <begin position="21"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="12">
        <location>
            <begin position="441"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3784533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="594" mass="63474" checksum="F3F9B41EE9C42395" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NM94</accession>
    <name>A0AA38NM94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_352258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793318">
        <property type="protein sequence ID" value="KAJ3786273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NM94"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="337" mass="37402" checksum="31523FD724266580" modified="2024-01-24" version="1">MNVITSRSLTKAHLLRTQTRGYATISSSGPSPSLTTHTLGPFQVFDRETKRKQRDRAAYKNGGASSRTVDYVRDEIADRMMERLEDIKRKFSTIVDLGSCSGHFAKLLDPSTTRKCIMIDSSHGALHRDPDSEFEVEVERIHADEENLLQVINPNTQEAIVSCLSLHWVNDLPGILIQIKEALQPDGLFLGAMFGGETLFELRTALQLAEVDREGGISPHVSPMTDTRDVSNLLGRAGFTLLTVDIDEVKVAYPSMWELMDDLRDMGESNAVLGRRHIIHRDTLAAASAIYKELHGNEDGTIPATFQVILMIGWKPAPTQPKPLERGSGKTNLKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMD4</accession>
    <name>A0AA38NMD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_419093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793311">
        <property type="protein sequence ID" value="KAJ3786558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMD4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="39621" checksum="F0258D3C9233E20F" modified="2024-01-24" version="1">MRSLPKFKTIPKNHTFVAYTNLFLTSIPAKRVQNELYARALHRDPIMYGMIPGLTKHGDLGAFVLIEEHFEKIMKYVAKKNWDAVYVLLDGFIIYIHRPCPAPTDTSGIEREHGLLRLHGACLMTMFRELDKQGRLNTQNFPGLEYFLRYTIRWIEHAKDRLVGIFHLGSDILPHLDVCKAIAYRLFKNQTVEDLNLHLTRIREWVQWLEPRVTEDDHDYAGTKVWVQDCLIREWPWLLLGVKPWYLEGRDDDVSKKGLELNLEEEWSTFSDYRKENPLVPPKGLSWEFKDWSEEEREAHRGETVYEPSDEEEGDDDDSSDTESMGWGMERSFWKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMR3</accession>
    <name>A0AA38NMR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_349931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMR3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="214" mass="24384" checksum="E2A1BF3B29510025" modified="2024-01-24" version="1">MSASSPYSDYFRCRTVGRAASPPTWACYEQIPYDEDYSDSESELCSEDDEEYHSNSAENEHVNDLEHEHVNRQLRADDSNDLDIDIDEGAEKTEGIEKEEPAETKDVKGKQKAVELESEPAPGPPKRHHRRRQRHNTYALRPILTIQRSQGFVWNQDLFIPPYIKDRYVASTSPPNSSGFISTSVSSTNSALNDYEVEVVEIRVQEGDLEHIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMW8</accession>
    <name>A0AA38NMW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_265186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793294">
        <property type="protein sequence ID" value="KAJ3787339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMW8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3787339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="350" mass="38353" checksum="4E183ED56F147181" modified="2024-01-24" version="1">MTAESADCHSIPDRDRVLTTGPLQESDLQNLAELGMGNGGSVMKVEHVPSGVIMAKKIVLIDAKPSIRKQILRELHIIHTCSSPYIVSSFGAFISEPNICICMEFMDQGSFDSIYKAIGRPIPICIVRQAAKRVLGGLVYLYEAMGVLHRDIKPSNILLNSEGQVKLCDFGVSGELENSVAKTFVGTSVYMSPERIQGSDYTIKSDVWSLGITLIELAHGCFPFADTEVDESPLDSGESILSAPSAALSPTTHARRSRRKSKGVSVHGGVGTLSILELMHHIVREPPPALITPSIPHSRDFAGEAAQFVDHCLRKNPSERMSPRDLLTMSWMDDEGREDEIDLRTWARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMY8</accession>
    <name>A0AA38NMY8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_381555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794086">
        <property type="protein sequence ID" value="KAJ3779900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMY8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="75"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3779900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="712" mass="76466" checksum="168334B96B9EF50B" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNI9</accession>
    <name>A0AA38NNI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GGU10DRAFT_345978</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1224"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1249"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="323"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="672"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="998"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1314"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="935"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3788479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1576" mass="175425" checksum="5A2486FE01CF9CDD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPC9</accession>
    <name>A0AA38NPC9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxalocrotonate tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_435417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793385">
        <property type="protein sequence ID" value="KAJ3784235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPC9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="149" mass="17348" checksum="6DFC21D824CA46ED" modified="2024-01-24" version="1">MPFHRFYCSPNLYTKEEKQAIAQAITKFYSRLPPFLVLVNFIDVDKDNFYVGGEPNDKYLRINVQHSANPVQTRAWVEAYEKALEPFTKGKGIGWELQMTNEDPLFWNANGMHVPPFLSEDYMKWKELNRPVEWGAAVELEEAGSKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPR5</accession>
    <name>A0AA38NPR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Component of IIS longevity pathway SMK-1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_352262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793318">
        <property type="protein sequence ID" value="KAJ3786275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPR5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="271"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="913"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="929"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1146"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3786275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1167" mass="129849" checksum="59EDA1203630710F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPX7</accession>
    <name>A0AA38NPX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_331763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793297">
        <property type="protein sequence ID" value="KAJ3787205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPX7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12372">
        <property type="entry name" value="RRM_CFIm68_CFIm59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3787205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="338" mass="35794" checksum="6639254F516D6BB3" modified="2024-01-24" version="1">MQQDDFDIYGEDLQQQVQNEDPEPQKVPTEVNKVEPSVGEKRERENSEEPVGHQEEQSIAVMAGATQMPGNTGLMNTQSSTNSDSLYIGDLQWWTTDEDLRQVGLMLGVNLDHKDVTFSEHKVNGKSKGIAYVECGNYDNATALKNWFDNNDFQNRKVTATLTSSSQGNPFRTLPKEPPAREGRVQPSQNGVMQPQVNNTRGGGTFRGRGGMRGGVPSSGAGPGNMGMGNMGLNMGNMMGMMGGVGVGNMGMNNLGMGGFMGGGGTFGRGGGMMPRGGGMMARGGGMMGMGMGMMPNNMMGMASGRGGHFNPAFVQGGGGGGFHGPDGPRKRFRAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ54</accession>
    <name>A0AA38NQ54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_385051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ54"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3788360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="506" mass="54930" checksum="CE657F9629C0E40B" modified="2024-01-24" version="1">MLRRFVSNAADSLREKDAPFNAFVSFENSLNLTNNGKGPLNEYSIGIKDNICTSGLPTTCASAMLQDFRSPFDATVVKLLKKAGAQISGKTNCDEFGMGSLNIHSLHGPVINPFRVDSRRAAGGSSGGSSAAVAAGLCDAALGTDTGGSIRLPASYCGVVGLKPSYGLVSRYGVVSYADSLDTVGVLAQDVERVEKVFECINKRDCNDPTSVDERLREKAHLLATKSIQRWSGESLKGLRIGIPQEYFPSELTSSSYHILASIRHLLSQLHSLGASIVPVSLPSTAYALSAYYVIASAEGSSCLSRYDGIQYGLRVPPSPESNFTSTSRTYSPSRSQGFGREVRKRILLGTYALSADAFDNYFLQAQRVRKMVRDDFDHVFSIPNVLYSKLSFEEKDANDHGEDGVDILIHPSAIRTAPRLDDVLDVSCDRDTLQDYVQDVLTVPASLSGLPAMSVPMRPDAGLNQPRDNQQSDENWPIGVSIVGQWGTDELVLKVGRVIERLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQL1</accession>
    <name>A0AA38NQL1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_343749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQL1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="383" mass="42495" checksum="6330C47D7D585250" modified="2024-01-24" version="1">MASSSSSSQSSANQQQAQPRGPAFAKWPTVKIFLPPQGRFSPKRDEWCLTYCTQSITGRIHAAQPSCTTLCIRKVFEHEVKNVAGFKRHDVSVMRDDDEIGVPESRHEVQEGDGKGRKAVGKKAIYPLPPEGQPENVSKVLGGGMATESESSPSTTTSSSSTLPPLPTTSTPIIKTRSWSPGYYLFTSTTIYGTFEHLVSMSRDLPRQVVRQKAVENMKREWIEYQEWTEKLRRGEIQEADEKQEKQRTGKSENDANGGQSGHQPEDNSETKVFGRTRPPRPSPDYLSSTLLVPLPPASLSHINSQLTSQFLSPMSKFLKPSGRALELLRNDLQGGIYQQFASRVYSKAQTDEPVKLARRSWERLLEAWKGDGGDGKDGGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRD2</accession>
    <name>A0AA38NRD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_342576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793257">
        <property type="protein sequence ID" value="KAJ3789686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRD2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="260"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3789686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="532" mass="57157" checksum="C7064D6BF7D1D055" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NRZ5</accession>
    <name>A0AA38NRZ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_383573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793253">
        <property type="protein sequence ID" value="KAJ3790038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NRZ5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34522" checksum="FBBF38C63CB1369B" modified="2024-01-24" version="1">MDTLPTEILTVILAIVLQDTKSTNILCTSSLFRSIAQRILHQDLCFFSSSQLTKFAHVLSTGALSLACEPQSLMLDIAGGASFKIFEGLHAVLTQIVSDPQCKRDENGRLILETLRLRLNSLTHDDHRLICTSLSKVKACPPHHFSTAIVSPAVFPLFKALATYTRLTHLHLTNIAFPSSVINPDARWTGIPCLPSLHFLYLGQATFLTAEHITDFVLRCTGQLQNSACTSKLEAHSGYVLECIRLVDVYEESIWGPRLKLPHILLASATLLAESGSSKLSSSTASDLIERLVRVDAKTERITGGDRAMPEVSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSC8</accession>
    <name>A0AA38NSC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_421761</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MU793252">
        <property type="protein sequence ID" value="KAJ3790193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSC8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041201859" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="177"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3790193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="554" mass="59996" checksum="7F58E2EEC504F681" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSD7</accession>
    <name>A0AA38NSD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_431061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSD7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54218" checksum="DE11B25BBAE9A0DF" modified="2024-01-24" version="1">MSDIPPEPIPPAGYLSRKALPIKRNDAEILTREDVQYDFLHYIFLDETAVFTPQTPASASKITFRELYVNALYHSNKCSKVLKDKMFETPEFGVELAKISLLTNVGRINTTMAFFPEMKTALRTYHPVPSLQKTDGNAQDAPRIKNCLKAALLPSEFKSLPPSTPEEVLERRKAGQCPPTSIVNLIFVLSNHAVPLANVHFDGTVNFLDLFLPKALASSDRAKAFLWIIYHYLESDEPPNPFDALNSHLMPGKAPYMRPLTRMEMSRENVDTSEELEWGKRMSAQRNSFLQKLVTAMESEKKSKPAAPHFVTVAPQSQPNFNTPRTRSTRRHPEPSKENGPFMYYVPGEDPSISHDPASPIPPPVSPDPMIELEEQRILSIPTPVLANIPYFPEIHFDGRSLLQHAWRSVTTSDPLLDSDEENGDDGDIRIDYSQRLSLISAIRGRPPTPEQPSHIIQPSYLPSSRPKTFTRWQPVESWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSI0</accession>
    <name>A0AA38NSI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_179938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSI0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="92" mass="10892" checksum="59CBA42744924828" modified="2024-01-24" version="1">MPRYKKAVGKTSRGEDLWAVDKVIDDRMNKDGNVEYLIQWEGWPKSYNSWEPVEFLDRCGDRLLRYFEYRRDQFVREHGSPSKVSGSSDNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSI8</accession>
    <name>A0AA38NSI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBS-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_179869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSI8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="171"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="278"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="355"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="506"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3790337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="74483" checksum="C85603D9E0EF96E6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSL0</accession>
    <name>A0AA38NSL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_383307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSL0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3790386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="469" mass="52989" checksum="ED7D6C2A71CC575E" modified="2024-01-24" version="1">MSSPSGAESTMTSVMTAAEFKSWTVAPTLIPSADHTNSTSTRPPSLYDKHIPKALQPKIIYLGKPHYQPDSSAISDPGFAIDHYYSQLCKRPDVLKSLTGTVRDDLRSRWKFFLQHVRHLSIQNEEGVRFAEKLVAEIVYNLTSLLLFDLSKDQLENFGEWIALATHSNTESGTNADFLLGLHGKDAILQRDSRNSAQSRCEGIWPFLKTLDLDFMHHIVLVECNNLRLGNPMGYLAILLLSCLTQKVQVDLWPEAQCHGCGEFCESHKVQFGHAPVQPPLDSPIASAYGLTAVPLHSEAAIIHREIGRVLGLVLENHEPSAIVRDATEHLQGRPNDFGNFADLVREPMRNLLLSLEEVQTIKVLDQFCDKDDLLKDIMWWIIRMRDIFVQACSQLIGHNLTFCIVTSYNDSYFFQRNRQTGEITMSPLQQVSKKGHIIQRAVLCSEAFYDSKDRSQLNEELVTNETRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NT45</accession>
    <name>A0AA38NT45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GGU10DRAFT_425013</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NT45"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3790586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="563" mass="62298" checksum="F45DC2FBE254F02F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTN6</accession>
    <name>A0AA38NTN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_424750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTN6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689:SF1">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="313" mass="37473" checksum="0AE3FE76C1BBFAFE" modified="2024-01-24" version="1">MPRDRDDTRRARSKSPKREPQRDARERYTSRRSRSRSPSRSRSPRRSKKYRDMSEEKASHRERRSRRSRSRSRSRSPVTKRRRYSASPSRSRSRSRDRKKRKGRADSVSSVSSSDSERRRHRKKKEEKRSKSKERERKERKERKREKKERKEKKKKGTTQWGKYGIISEVDIFSKTSEFQTWLVEERKINPETISKDQNKKEFARFIEDFNTATLPHEKYYNMEAYEKRMSALRSGEFLPPTDDYYDPSADMKALSNAHKKKGTDSSMYLSKEHLMELRKVQNERAEAGKMKLLGMDIKQNLGVRMDGTVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTN7</accession>
    <name>A0AA38NTN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_339146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTN7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="67284" checksum="B4D84C743E7EDDB5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU08</accession>
    <name>A0AA38NU08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_66176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU08"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="844" mass="94464" checksum="33B96BCFD7A6E8EC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU42</accession>
    <name>A0AA38NU42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_281014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="468" mass="52044" checksum="291C5B8CB9AE3425" modified="2024-01-24" version="1">MSRSSYRLEKPKRQPPAPLHFEHSSYHPKTGISTHPSPTLLYDLPSAISLSPPTSPTSVTRLASPPTSPGRSRPHRGGRPTPPPGGRKRSVTPMGVATSDLEDFSTYCRNWYFKQDEEAGRLMTQTMANLPPAQRAPYSRLQASIRSAYHRSVNARRTAEFRAHLSATQPGVSLTPYARANPRGSDAQKERYQSFERFVRSWCSMGMPGPQPFFQALWAVMRLQVVPENIGGAGRHRIEWEFDDAVLKEAAGKDFMLEAIDILKGVLAFEEVPSSRMSPPPSGEENPDVTLAHSRSQSSFLPERKVSDTVLPKRARAPSDPFLDTPMLSRSVGSSSSNMTSLLVSDNSEEPLVPASTLNEDVTPMLETPGDDSEEECMRTWTSPDLTNPEYLNLLKVFPSHITRRTLPYFPVSPKKSSDLEAGLDDAADGKQVRCGTGTLGISSMQRGDGWEGGWWTRFILWWRRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NU87</accession>
    <name>A0AA38NU87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin modification-related protein EAF7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_338325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NU87"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3791259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27066" checksum="9D048DFEDE3B16C1" modified="2024-01-24" version="1">MAGSSAETPAFLNTVEGEISFFRSIMRARPVGIHRHFHVLTMRSSIHKDTGHWVAVDELWQKLKSCYDIDALNSIEFEYEAALSKFPPPQALLTDADITKHHFVREEFSLPSEPSLEALISTRRVNPIPSPPSSPETSSTSPAAMKAKVSRSKKNNGKSKASMAGLVGGESDSSDLTDSGEEGQAPSVITATDGGETVDGDADDDVEMRDVTPDTTKSGRRKSTAKKSVPTRTRASATNPSARPAKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NUC2</accession>
    <name>A0AA38NUC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_280762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793244">
        <property type="protein sequence ID" value="KAJ3791228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NUC2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3791228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57877" checksum="0BD1911C1EDCA738" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TXY5</accession>
    <name>A0AA38TXY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_305526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TXY5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="128" mass="14007" checksum="49BE1488DA2D535B" modified="2024-01-24" version="1">MPEVVFTPEANPVLPVFSQAVISKGIIYVSGNIGCDKNMKIVGDIKAQTRAALENIAIVLKASGSDLNYIVKANIYLTNMARDFKPMNEVYAEFFDKDRMPARTCIGVAALPMGADFEMECTAEIPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZI5</accession>
    <name>A0AA38TZI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_344114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793263">
        <property type="protein sequence ID" value="KAJ3789283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZI5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="42"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3789283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="568" mass="62336" checksum="0C7422E2D6D00991" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38TZY6</accession>
    <name>A0AA38TZY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_383406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38TZY6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="296"/>
        </location>
    </feature>
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            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="656"/>
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    </feature>
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            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="105126" checksum="A47534DDF02F07CF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0E3</accession>
    <name>A0AA38U0E3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_158565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793249">
        <property type="protein sequence ID" value="KAJ3790499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0E3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48084" checksum="FF319F23427F9FC3" modified="2024-01-24" version="1">MYLDVNRQTTYWLSIDCPNGILKYGKGYMSSNLTLLEARLKKLDEHGCMVWSEETWSFLEKIKEVRVLQTGGDMRALSVTTRTLPLVDAPSPYVLPDYRISMNDLESNNYTVIANLPVECQKLYANVAGPNIVLNTPDFPAFGRAIERSVSTEGCLGYTLLMRKAGEFNLTQTYLRITLGSHMVNSPGIPYVLEIWPAGHYSPIHEHADSFAIIKVLYGTINAFFYDSIVNPGGPRLIMDKVELKTGDITWISPQHYQVHQLKNLSKRKEDGGEGTVCCTLQCYQYAYNDKIHYENFRYIPNSSNSSPTSSPNDSGYESEPDMMDFQPNSDMSFGVFKAAIRREWEEYMTTDIGRKEEAEYLTAEKAKNLAAAMKGLKAEGEIDGNSAAAKKAAELADIMARRERMVEMGMEGSMEARAEAVMMEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U0U4</accession>
    <name>A0AA38U0U4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_371689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793254">
        <property type="protein sequence ID" value="KAJ3790018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U0U4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="829"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="702"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="911"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="965" mass="107827" checksum="3529EBAB6196D1C8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U156</accession>
    <name>A0AA38U156_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_370579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793245">
        <property type="protein sequence ID" value="KAJ3791007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U156"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3791007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="430" mass="48385" checksum="9BD088401B8263E2" modified="2024-01-24" version="1">MSYRNLHSRRTLSDPAVPSALNPSTRIGKSDTRSDSPLTPIESEGLSRVPSPKGQGYESALSEPEEAESGGLAEKISDSSQTSETTGGRVDPSGDLISNQMRTDEPAVNMKSVSNVHNRNSLSSEQELTIKMAEANLDPEQRELIDRRQSSVRIMDVDEVSHGEDSSSGKGKGIDPRNWGNVALDSDESNPEVQAQILASIGETSKKREASRERRMNIQDMFEEFQPWQRQETQRIEERYQSKLDALKKAYMHQGITEAEALEHPEGSTTEEPEIKGEEKVRSYENTTRRLPSRPSELIATTSHVGKLFNQLTAVKRSGDVPREETEEDPLEDVGSTARKAKGMRIKPLKPTEIYDGTASLCSFQRNMREIIAYLEDGQVPEYRQIEVASRFLKGKAYTFFERTCGESSSDWTLKKFYERLYDFAFPIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38U641</accession>
    <name>A0AA38U641_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_26632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793256">
        <property type="protein sequence ID" value="KAJ3789825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38U641"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3789825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="375" mass="41742" checksum="6ACA33CB88210375" modified="2024-01-24" version="1">MPLQNITTLPLEHSVPNEVLFEIFNNLPVSNLATLTSVSHGFNAVAEHILYSSISIRDILSTSSPFPCRTKRCCQSIMQRAHLGKSIRGFHIRWQIDVHTSSSCNFDLGPTLLKLERVLRSGILSSIESLELWLGPVNRVFHSSIPHTIERIIYGSHFPQLTSCSLGAEWAKGLPSYSDVLDNFLGSLQLLRHLKLHDHHATLNLSPVALPILSSFRGSPATSASLLPGRPIQYLSLIGDDYDVNQEILTRFAKTTVPLRFLDLSGMSVRPILLRNLAAYLPAIEILKVRLALRHTLHYALTGIRLLTGLSSVLSTYHQLVHLDLSPTSVAGGDAEQELSLCNEWYCACPSLNRITFPSHTDWFLDSEGLWICRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7E0</accession>
    <name>A0AA38K7E0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_231836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794301">
        <property type="protein sequence ID" value="KAJ3779724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7E0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="125" mass="14655" checksum="16994F17CCB4168B" modified="2024-01-24" version="1" fragment="single">FWKLCDLYSWDRESDKRKEALAEIRNAIAQSFRAFYGSNVESLNGWPSSPVSSIANPRQAVYGSRLQGRERFMVDICDLVDFEERFLKRMGQKLRLAGYRSRTGKIYPRDNAYAGGLFRFLWRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K7X3</accession>
    <name>A0AA38K7X3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_321050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793625">
        <property type="protein sequence ID" value="KAJ3780939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K7X3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3780939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12463" checksum="1C12E9C73B0583CA" modified="2024-01-24" version="1">MHQKEFTSLPPRPKPYASAEDALPWYSWCEPNTKWPIDDSVITHEYIEEVVFLEGGLKDLTLQQEWGPGAYAYRLPGMKHGPYEASEKGCLEFVRCVGVRMEAKDDVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K8S0</accession>
    <name>A0AA38K8S0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_378398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793463">
        <property type="protein sequence ID" value="KAJ3782634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K8S0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="222" mass="25359" checksum="9276F325F6671136" modified="2024-01-24" version="1">MTEGQNSTNVQTRILAPSQISNMPPIIPQKPANNSRVFSGEAQFQSSEHILSFDNLLNHVKSLKQRLTHLGIQKASLEEEVDQIRHELSEKSREREEKIFALTQENAALFAHLEDAKGIILRLKSQNNVILQEAQERVTELERTLAISIAAKEELEQKLSKQTATLQALSNEVHLQAYSRLHLAGENKRMEKEGWNLKKENRIMSDELNQCMLLHPSLQPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K922</accession>
    <name>A0AA38K922_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_273532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793419">
        <property type="protein sequence ID" value="KAJ3783444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K922"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="346" mass="38240" checksum="872DDEB7525B89B9" modified="2024-01-24" version="1">MECILYGVYLVSLGYCLRALLLDPFEQGLQRKKHINWVMLVVALLLCLFATLDVAFGLRHNLDAFSYYHGPGGATEELNDISYWVNVMKTADYVAQTFIGDGMLIYRCYIVYEKNWKIIIPSILFWLGGSVCGALLTYTFATLRSPALIDTSKAVPYVDTMIALSLTMNTLTTALIVGKIWSVDRQNATLMSNTTANAMRTSKLHRVMRIIIESAALYTISTLIFVITYVAGSNANYGTSDNVVQIIGISFNLIIIRVDAGKSYNGRIAESSTNLSSRQQPRNKPQSFPLSLFNTTTDSALNSNSDSEFTGRKGITLDVDVVHKYDDLEQGTNATGARALKPLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K9A3</accession>
    <name>A0AA38K9A3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_396067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793399">
        <property type="protein sequence ID" value="KAJ3783894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K9A3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3783894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="60555" checksum="229C2E9DA4B9F0EE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KB98</accession>
    <name>A0AA38KB98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794148">
        <property type="protein sequence ID" value="KAJ3779848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KB98"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="309" mass="36296" checksum="8F7A15B5892B7D80" modified="2024-01-24" version="1" fragment="single">MSSPLIPDDEVPPSVSSELEVYLEDLKRKKKKARDLGPSFQQSLSIRRRYFPDAVSLMQEIPEKDDILAKKTTFLRKFQKKTTFLRSVHNYYNDFPPHLGSAFQQSPSIRRRYFPDAKKTTFLRSVHNYYNDFPPHLGPSFQQSLSIRRRYFPDAVSLMQEIPEKDDILAENAEKDNIFAVKLPNRVGFLAQWQKTFRTRIRKLNKIERLPKLVTEFETSSGDSFEVKEPKLLQAFRAVGVVPFWEEECPAEYEEQWGERWEHIHETLEEMSNIARKTEVDKFHWTKMDVQDVAKAARDGGWEACLDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KCU1</accession>
    <name>A0AA38KCU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_239915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794263">
        <property type="protein sequence ID" value="KAJ3779756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KCU1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="237" mass="27590" checksum="48C608A6C79CC6E2" modified="2024-01-24" version="1" fragment="single">NPLARPCTVDDFRYWLAGGPKSEWNQAASYIFVEILEQKRFITTPDASMRDALREAFHVRLKSLHKTWLDKLKMEVDADDPDAGRPKTWQRKYTVSHCLFPSKDLQIDSLKKLFHRRRDAVITIPALNPYLEDFDQLGAGGMSSDEEDPGMSKPSMAYNIREPKWRSEEVKRWLRLLDFVHLESRCSMEGYQFRFSRGAPPRLRVDNNNKSSNAKYVRGLPSNFYDAGWLEAMEPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEA7</accession>
    <name>A0AA38KEA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_80648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEA7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041361172" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="272"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="497"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3782441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="645" mass="65407" checksum="FFC06DB539636709" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KEF6</accession>
    <name>A0AA38KEF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adrenoleukodystrophy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_7039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793347">
        <property type="protein sequence ID" value="KAJ3785293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KEF6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="463"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="708" mass="79190" checksum="9D703EFDDE4A8B13" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFE0</accession>
    <name>A0AA38KFE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_334343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793397">
        <property type="protein sequence ID" value="KAJ3783956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFE0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="107" mass="11893" checksum="BEA5BF04F2DAB815" modified="2024-01-24" version="1">MTRNLDPSMGQLPQLPGDSQSEEHIQKSVKAMQPERITIKVPEAPDGVPSMGMVAVTQGGTRKGYTVLGSMMGLQRSFWQCFLHAIWVSLQSAKKKEVPERRTEPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KFM9</accession>
    <name>A0AA38KFM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_29723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793379">
        <property type="protein sequence ID" value="KAJ3784361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KFM9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="834"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3784361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1063" mass="115427" checksum="C5B01A3CFB6C7073" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KGG5</accession>
    <name>A0AA38KGG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_346794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793278">
        <property type="protein sequence ID" value="KAJ3788248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KGG5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="333" mass="39426" checksum="B1D3EF714AFA746A" modified="2024-01-24" version="1">MLVRPRLWLSTESSNSWTKRIDLKRIYPQYTLRQKSDHEIRLFSSSHRVFKEDVVGTKLDKRTNHSSSSSTNNNVSARVIPRPTAVSRTRTKVIRTALGYNKEKWNVLLSCVRDNLAAAQLDWSIAWEAQKPEKLAEVFNAVEEHFPDTRRFADHWALKRLAIQYWNQRKYQLRMMRDPTSSSKAKDDVPARNIPCLIPTYKVPMKHIRTTIGYDQRKWNRLRTCLRENIVIARLKWSLHWRFQKPEKLRQVYDAVENHFPEMRRFAEQWAAKAMTKVFWDSCKRRGRQPFSLFTDESIDSPKSTKPIKKNKASGRGRGRPPKNKHRRILDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHH3</accession>
    <name>A0AA38KHH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like snare protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_348421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793289">
        <property type="protein sequence ID" value="KAJ3787586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHH3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="735" mass="83031" checksum="CED55074E0CFB070" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KHQ1</accession>
    <name>A0AA38KHQ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome-c from the OXPHOS pathway</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_123523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793280">
        <property type="protein sequence ID" value="KAJ3788096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KHQ1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3788096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="108" mass="11774" checksum="FE14A2F5415CB6C5" modified="2024-01-24" version="1">MGYSAGDEQKGAGLFKTRCAQCHTVGAGEPNKVGPNLHGIFGRKSGQAQGFSYTAANVNKGITWDEETLFEYLENPKKYIPGTKMAFAGLKKDKDRNDLITWLKTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KL28</accession>
    <name>A0AA38KL28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_367832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793607">
        <property type="protein sequence ID" value="KAJ3781079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KL28"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041246431" evidence="1">
        <location>
            <begin position="37"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="294" mass="33417" checksum="B5F0FB2AAE318662" modified="2024-01-24" version="1">MYQRLRSRNTNSSHYSHFTSFLKCLLFATVIGACIASPVPSGGELEISSDLSSTAHESFIRSQVGHWYERRGVKDLKNKVKKKLNIGGKKDEEKKDEEVDDGENVVLGYTYHDDDENFTKAHPRSRKSTTTGRTALERLENIVSVMHKTEYSYFFPGPNYYNKFVSRGYHQAKTMVSLSHFDDVSFAYIPMTTTLEEHSLKEAAENSWRRKVTSGKDGKVEVEERTGKPNFSNTILIVELARSRYAMLVPKAVIDSIPGGLDPKVDSHDMPAATWQNWEKIKELGVAKTFIYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KLE9</accession>
    <name>A0AA38KLE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Six-hairpin glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_390553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793548">
        <property type="protein sequence ID" value="KAJ3781544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KLE9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15662" checksum="01CC215942DB4C6C" modified="2024-01-24" version="1">MPSLRDFDAPLSPSPRPADSSAATIAANGLLLLAQVDPANATNWSNAAIQILQNVTSLAWDSSWQSLLSNGTVNWPENNFLTGIVYGDYYYITAANMLVQMGLAECKEVAASNSTPSAASNGSSLARQTSWGIKTYIFIVILAANIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KMP7</accession>
    <name>A0AA38KMP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Recombination protein Rad52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_78485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793471">
        <property type="protein sequence ID" value="KAJ3782520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KMP7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="69691" checksum="6A41F42B263E2C6F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN42</accession>
    <name>A0AA38KN42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_397816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793768">
        <property type="protein sequence ID" value="KAJ3780366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF219">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3780366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="524" mass="57759" checksum="E294861DAF772316" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KN68</accession>
    <name>A0AA38KN68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_321726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793736">
        <property type="protein sequence ID" value="KAJ3780441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KN68"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="191"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3780441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="757" mass="86071" checksum="B0D85E2BC17CF555" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KNL1</accession>
    <name>A0AA38KNL1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDK4/6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_437646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793637">
        <property type="protein sequence ID" value="KAJ3780876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KNL1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="337" mass="38760" checksum="A678E3B4FC69973C" modified="2024-01-24" version="1">MNILNERQPQHNARVFPSTGFKTIPESEIFEEENWPWYTPQSFYPVHIGEILHSQYQVLYKLGYGTTATVWLCQDLRRNKYVCMKAMVCDYSSVQREIEAYEALSKSACNEKQFVRRALDHFVLIQNELSYHFLIHEPLGVNLQYIISMARGRLPISAIRPIIVPIVVALHYIHDAQVIHADLQARNILFSIGDPTVLKDGEEAELKLPSSRKIFGDTVIFETRDLPGPIERWVQKRSQPILCDFGEARTGKDQYTEIIQPPTYRAPEVFLHLPWGKAVDVWNFGCMVWHLIFGEQLFSREDALDEDTADVNQLAQMYALLGPPPPKLLIDSGPHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KP71</accession>
    <name>A0AA38KP71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_320127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793546">
        <property type="protein sequence ID" value="KAJ3781551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KP71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3781551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41524" checksum="E8D953AC0E684300" modified="2024-01-24" version="1">MLKSKTRFIIYNNNTIFEPDYSDERKPRKRARIEDKESDELAGLFRDSQYYDSKLPDACVVLAGDTLFKVKINALSKLSLKLHAMVDGTETSGDCNPVRLDAEPDDLRALLWAIHTSPDELKQPIKDISHLRKFCSLARISHAFDCSSQKSLALSAIRDALDNSLSETCSSSDLHLLAETAVGCETPILLDAIVSRWIKRIQRHQVPSVPGIISADTLRISRLSGAAYYAHLQEVAEQSSTISDQGVTRLHMDPKLDMSQKMHLLAGYWSLVNYWEQLRRHPLKFVCCSHNKCSDIWERRWAVALGAPKVLCASQVDVLGLIRIMRGLLVVDQELETMDSKCRAKALQSLRDACENLNDTLGDHFTNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQC6</accession>
    <name>A0AA38KQC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_354990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793343">
        <property type="protein sequence ID" value="KAJ3785400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="157" mass="17607" checksum="7C2E0056DFC800E3" modified="2024-01-24" version="1">MTSSAPSVNPEQAPISVLIQYIPISANYFAKTARSLFRFASWLLRRTLSYPSAIILSPLAILFSISLYILAPVTVFMQVLLDVFVLMPYNMVIYLVDAMYPVYVFCGVACITGVIVGVLARQLVFWLVELGRLDKVGRLPEERPTEVVAEKVEWDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KQD9</accession>
    <name>A0AA38KQD9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_290232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KQD9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="78307" checksum="FAEB8797CF3CDD17" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KT46</accession>
    <name>A0AA38KT46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_267030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793313">
        <property type="protein sequence ID" value="KAJ3786486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KT46"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3786486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="713" mass="80438" checksum="43F4F5A8B28B1536" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KUT4</accession>
    <name>A0AA38KUT4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_384439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793265">
        <property type="protein sequence ID" value="KAJ3789141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KUT4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23153:SF38">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23153">
        <property type="entry name" value="UBX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3789141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="241" mass="27718" checksum="8A946A57899F22FF" modified="2024-01-24" version="1">MESPSPNQFAEAVERRLSLQHSQGPSPAELAAEHAKRQKFRRLIDPGILRPNPELQAVESLKILYKLTENLIREPENPKFQRFKTTNAQIQKHIIIPKGTVEFLRELGFHPEVDDFQPFFVFNPKRMSDLKIGSAMLKESLDLQEQKRARAMESKQTVQEARAEVIERVHLAFMDDRRAKMELDEREKQLRAARAQAAARQEAQQMERSRSRHSTGDDEDAMEEPGHSLSSAADQPPPYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV42</accession>
    <name>A0AA38KV42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_377776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793425">
        <property type="protein sequence ID" value="KAJ3783327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV42"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="229" mass="24947" checksum="0581266CF99F3C7E" modified="2024-01-24" version="1">MPIHVSCTQVLGGHSEEYLDLNVKARRMRIGVEVFGTIGNKETSPTSIYNLDNSTSSQLTFPTNDETNYRVPFYKSPLLSPGDHTLTIIVPPGNKNGQLVLDYIIYNPTPTSTSYATITTSVYRSASAISTPASTHSTSVNAMTVGVAGGLGGLAAGIALTLIVLRIIRMRSRGHAVTIQRKEQRLRDTLQVSSVRTMDFNTPPQISPNNSSQMIQEEMAERPPPYANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KV43</accession>
    <name>A0AA38KV43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_317007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793424">
        <property type="protein sequence ID" value="KAJ3783342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KV43"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3783342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="227" mass="25587" checksum="C331BEC1BE0C1C8A" modified="2024-01-24" version="1">MSQISCRHRQEFFRKTSALKHDSLHHSFSISVASSTERQPEQELPFGTFADPTRPGLFYHFLEPPTSISPDIPVYALSFLPAAPPNPESSTVIGWLPASTNNEVEQEAGLNDFKENPKFRQLLHDAVKDGLQFDVDDIQRNGALQIQQGWMHIHDDRNIPALGRIGDPDDILASVLVEDGKILADTYQPMPAYRICTSDGITQLTEGLSGHLQKFLWQHLDSERKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KVE6</accession>
    <name>A0AA38KVE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_359404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793396">
        <property type="protein sequence ID" value="KAJ3783972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KVE6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="219"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="347" mass="39137" checksum="0EE3E2E280CAC7C6" modified="2024-01-24" version="1">MFPSLCSWSSFERSRAPDLSGYHHHSSDLIVDSVVHTPRKPSLKSVPLPGTPLLTENAPMPTYFPTDEPSGRSSRASERPPASHGSYSPHTITQTPNRPLKGILKKSGQSSNPLPNPTPLGQEEYRLESGSHSTQEGHHYSNQNVSPARRGPTRRGSSGGHTQTENEERGSSSGGARREFWRSATSPIDSYTIRVPMKPEAIALSWPLTKPNKRRTNTIRFDVAEDPTQDNTITISNGVYTTYLPKQMLRIPASTHCTLTEMRIYLNSEELKCWPINVQRNDGICCLDVFEAIYHTLHFPLTDEDDELIDKVNVRRRPDLRRVNLLRGRRIFRGLIQSDQNWIAMMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWR0</accession>
    <name>A0AA38KWR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_368618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793659">
        <property type="protein sequence ID" value="KAJ3780758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWR0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="4">
        <location>
            <begin position="300"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3780758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="573" mass="61759" checksum="B82E0D45B029B996" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KWS3</accession>
    <name>A0AA38KWS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_374909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KWS3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3786447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="534" mass="56137" checksum="509DFFDDFF8D0540" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KX21</accession>
    <name>A0AA38KX21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_397447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793576">
        <property type="protein sequence ID" value="KAJ3781298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KX21"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="147"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3781298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="477" mass="55202" checksum="1D0D22A44B1F1312" modified="2024-01-24" version="1">MLYDKTPQYPHFAHLPFAKEPFKAIYVFQRIITTVLLVPIWILANLPRSRRPRQSWSLRQIVFVNFTRRIYRVTEVAGVTWGTRNPEEEPGPKELKETVFEWAPPLKESLRKGVVLDRFGRVPFKRAGCFVWRREARNKKQIPVIGIFFHGGGYSQLSAHEKSRTSHIPRRLMKNNLFTEIYAVEYRLLQHAPLPAVIMDAAAAYSHVVDKYYGSDFASLTNKPARKPCKIILLGDSSGGNLALALARWIRDEQVLPTPDGLLLFSPSCDASHAFPSTDSSYIPRPHASTDYLTDTPEPRALMQRTFLGFKYRPGGTGWGQWKRGRSREGREIEEETRSLMEIIHSEYVSPASPRVLRRWGHIVDLYDGRFCVYFTLRDTFTPRNPAHSYPSRYPQFHTLFAQFPKTFILIGDAERLTTEVGNLARAMGKDWGSVQVRWIPDAVHDVFMIPPGWWDERIKSEVWEDVKVWMRGFHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXC5</accession>
    <name>A0AA38KXC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_95915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793523">
        <property type="protein sequence ID" value="KAJ3781808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1388" mass="145461" checksum="1CAA8DEFF9E1CBB3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KXH8</accession>
    <name>A0AA38KXH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_348088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KXH8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="612" mass="68915" checksum="F1C74D539CEC0CED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYH2</accession>
    <name>A0AA38KYH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_360950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793420">
        <property type="protein sequence ID" value="KAJ3783428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3783428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="473" mass="51238" checksum="FBD186D9BB87550A" modified="2024-01-24" version="1">MHTTPFVVPVSGKYDNDSEQEPSGRDIGDSSPRIEWALPVLSHSMSLSYALPASTSHQVAPRPRSGLPVHSPILSSSLPSHQSDSREPTEDDNYSPTPKATSTPGRLPLMPAAPNSANSATQSDPGNRSLRSPRRLPSRPQQLQVKNTETESHKETLDVSDAQYLTVPVDLNPAPPPYSGRHLESSKMAQAKMPTQLLAREGVALSETIPEETEQKIYTGLGSTRNFTRREPQSIPMTPSEWRTSSTAQSLTTVGSIGRAPRLSERQDETAAEMLFELLDDAARSSGTFTSETSAVVRPISISAKLNRTSSMSPPPRQPAITNSIGQIHPTRQRPRESATKIPRVTTKPEDESAHQITQSGLSSARGSPLIVPPQPVNPPPLSPPTGLAPSMSVPSNPRVIRSKIWKSRGMNDRSTAVNNELHSSVGTFPDTDTSNALNVSRSRSNSVSNPQEHLPELSRVIYTHDLTSTQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KYX3</accession>
    <name>A0AA38KYX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_395832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793380">
        <property type="protein sequence ID" value="KAJ3784343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KYX3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="312"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3784343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="451" mass="50081" checksum="49171543FEF79456" modified="2024-01-24" version="1">MTSAITKRLQVAICGAGIGGLTFALALSRYPDIDIEIYESARALTEVGAGIGIFPRPWKVIKMLGLEADLLQVTETSVVDGSVSGFRYRKSDQYEGKDFFTLVTQGSLMLFHRADYQQTLLNHLPKRCRTHCSKRLRSYTQRQSGPIELSFEDGTMASCDVLVGADGVKSAVRAGVLGEKARWAKGEGKWKEAAEILQHVDPIWSGANAYRALIPAQKLQAIAPNHQVLHTPGVQYLGKQGYIIAYRISGGKFINLVAFVVQHHLENTTFNGPWMSTVDVSAFSSTFTHWEPDVQILLSCVEKPMQWAIHTVRPMQSFVSGRVALLGDAAHSMTPHQGSGAGQAIEDACILAAVLGHPSTDRTNVAHRALRVYDSIRCPYAYRVMEASRINGRYFTLRLDEDGAIDIDKLPPKQQWEYLQRLGHAIVKNWEWAWTTSIDTALQEVLRLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZ83</accession>
    <name>A0AA38KZ83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_356140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3785003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZ83"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="511" mass="59063" checksum="C86793566293C997" modified="2024-01-24" version="1">MVDLPFDIWWKVFEILPPDARVHFRAVNRLFLEIARRVQYRYLVIDGYGKRTKRLMKTINSLSLGYHVQSLHIQPWAVSNLPSAKAYLGPGGRVSSVFDHLHSFFDSDFPTRRAEALVRERMRKQIRLVKETAGMLKFVQEYSLEWNVDRPYHPELFTAFLSLVDVSPFGQTLTKLSLKVPTDRLICLASVKLPALEQLDLQLVTMSLSERCINDCFDCFAVFVNNLCPTLSSLSVSSSHISLNLNLYRLFYLLGDFPHLRSLAVTIPYDGAHFSSLDSLQFFIRKHRQTLQELKLLCNRSAARTRPNDPCAKYWIQRTITDVCAFGNLTNLSSIELSLRPLRSELTPFLTFLASAANQLESLTLTDDALTPEEVERVLDAVTCRIPADSTNRNFAGYCNLGYLAIRLQYLCPYTVDLFASKLCLLRSLKLTFSDVRLHHRDEVQLSYTDYAYAYFEELRLFYAEMNSRWYPEWKLSSLAVSECPYRFEWGRDLEKVFTKCIPTLDSFQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZC6</accession>
    <name>A0AA38KZC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_398772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793347">
        <property type="protein sequence ID" value="KAJ3785273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZC6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="827" mass="92560" checksum="A8892AEFB1AB4FE9" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZI6</accession>
    <name>A0AA38KZI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_191846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793334">
        <property type="protein sequence ID" value="KAJ3785678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZI6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3785678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="326" mass="36360" checksum="820E62EE8492B134" modified="2024-01-24" version="1">MPFIHNEQTYATSKNIRPLGEHAYTQDSGDLMAPTLPLPQGQISNEDIAIITLTAILILICGTAAISFPIRVVRRTWTRSKTVDNFALQSGSGVRVGHFMICAAGCWCSGWIRNPHTILWIMGIVSPDSDPESPLYIVFDGDCRRDTSRLLASILKEGDHQKVIMLGTHIVYGIASGLGHIFENFPDLSNDTDHFNIFSDPQGIGRREISRDVKPTWGYFIKADSNVGLCSSLIREIFDDVNDIVNDWLPEVDANGWETRVDPTTMSYRQILAWVIWPCRNTTKLSAISIVDQGLSRHSNNKAEYAPPQLLVSMGRKYRATPLSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38KZV8</accession>
    <name>A0AA38KZV8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_310956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793314">
        <property type="protein sequence ID" value="KAJ3786428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38KZV8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="417" mass="46054" checksum="9704936700198250" modified="2024-01-24" version="1">MNSVNDAPSTRAFELAAHYGIPQSLPTPPRANLRTPANSAQPSYSEMVPDFEALRQSYLNMLSSTPSENPTLATVTESSSARLSHPATSATVPTTIGSQTNDSSLQPILDLIEASPEFKMANSFLTSPYTPYLDDFDTTPVDDSPFVADLNTPIMDHIDDMEYGVVDSSSWMNDDAVSPLFNEANLLYYAQPPAQPENKKQTQQQPSAEGLLHSDKLYTFSPSSPFLDSLVSPPTRLVRSPVIHPTSTLYSSPRVPTTASFKPAAAVTSRSRSKSRGPSLSATGTRRDITPASMVSLDAPTQNRNYILPSSTSRKANPVHAQKRSHSKAFGDQELDELIGETPPGPNATEIEHIEWKRRQNTIAARKTRRRKLEYLQHVEVENTELREDRDRWKVRYGVLEGVLKANGMVVPVWDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L0A9</accession>
    <name>A0AA38L0A9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_348131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L0A9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31535" checksum="A755AEFA267D8F20" modified="2024-01-24" version="1">MLSCRASSSKSVVAGWPFASSKTTIRCYAVSLQPGRVLPGKKYPRVFHDKKLFQYNWYTRILNTTDRSPLIFLHRDDFSANRLKKLRRDIQVASQKFIKKAGEAGEVIEVPTLTVVRSSIFGAALREFPNVSVEEVEKMIDGVAGGYAVLSLPVLDPPLLSAVLRAMDRSVPPRPEKTAEEIAKELAEKNADPAQPGRRMKRQRAVPVPDLKVMGALLEGKVLLPARMQEVSKLPPLDTLRAQIVGLLTAPSAQLAAVLSQASGGQLARTLEGFKKALEDGEALEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1Z7</accession>
    <name>A0AA38L1Z7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_124337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MU793613">
        <property type="protein sequence ID" value="KAJ3781027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1Z7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3781027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="333" mass="38510" checksum="54AEDCF92603DBD8" modified="2024-01-24" version="1">MVSVAPTKFILPDLVSDCPYPLHINRHRKQVTTETKRWLFKGDNMESKIRVKYHGLKCGTLSAMVYPKAAYPQLRVCNDFLTYLFHLDNLSDDMDNRGTMTTADVVMNSLYHPGQYQSPRIGKMTRDYWKRLISTASPGIQQRFMETLDFFFQSVTEQAHDRQESAIPDLESYIALRRDTSGCKTSFVLIEYANNLDIPDEVMEHPLIRSLNEAANDLVTWSNDIFSYNVEQSKGDTHNMIPVIMNHHSLDLQPAVDFVGQLCKQSIDRFMNDRAQLPSWGPEIDRQVRIYIDGLEDWMVGSLHWSFESERYFGKGGRHVKKTRVINLLPKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L1Z8</accession>
    <name>A0AA38L1Z8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Proline iminopeptidase</fullName>
            <shortName evidence="8">PIP</shortName>
            <ecNumber evidence="8 10">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_367910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="8 10"/>
    <dbReference type="EMBL" id="MU793611">
        <property type="protein sequence ID" value="KAJ3781042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L1Z8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="33"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3781042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="314" mass="35694" checksum="CC4F8C5BC30409AA" modified="2024-01-24" version="1">MYPEIQPYETSTLKVSDIHVLYYELSGSKDGTPVVFVHGGPGGGCDEKDRSFFNPRKYKIILFDQRGSGKSTPSACLEDNTTWDLVKDMEKLREKLNIETWHVFGGSWGSTLSLAYAQSHPDRVKSLILRGIFTLRKSELHFFYQDGASHLFPEAWDEYLAPIPEAERHDMILAYHAQLNSIDDSTRVQAAKAWSKWEMATSKLYVDPSYINRAESDVFANAFARIENHYFINSGFMRDGQLLEKQEIDKIRHIPCIVVQGRYDVVCPATTAYSLKKVWPELELHIVPDAGHSSREVGIAKLLVDATNKFANLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L2Z1</accession>
    <name>A0AA38L2Z1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_274975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793457">
        <property type="protein sequence ID" value="KAJ3782737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L2Z1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="195" mass="21478" checksum="D584EFA1E44D5756" modified="2024-01-24" version="1">MQRYNNNNKRPLRKRPIRDRTVTTLTGNNDNQEPPPPSSAASNISIGFNDDFQVFSPVNTGAASLGNLHFNQVEVAAAAMSPNFGFGFNSFVGPMNSNSHPSNSQQNVSSYHTQPTPMLPPGKPDLEILENLKERIKKGQHEFFRATPMPELLAELYLGPSAQDFDTQEKGSFPSTNGDGNVGKKVRVTILLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L427</accession>
    <name>A0AA38L427_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_318056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793456">
        <property type="protein sequence ID" value="KAJ3782755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L427"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3782755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="66547" checksum="46AFB0887EA30D5F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L446</accession>
    <name>A0AA38L446_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_362578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793449">
        <property type="protein sequence ID" value="KAJ3782860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L446"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041430275" evidence="1">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3782860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="93" mass="9801" checksum="1F65AE3B18564284" modified="2024-01-24" version="1">MSVSTDGNMPTSSAMVFLSKFTILTSLLFLQFAARVNGSPAVEHRTAESKICGLNSAPFCPPGYGCCGPFFEPIEGNGTAYGSCYPEHGICPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L477</accession>
    <name>A0AA38L477_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding module family 50 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_13914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793358">
        <property type="protein sequence ID" value="KAJ3784957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L477"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3784957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21928" checksum="6AC9377F1C376420" modified="2024-01-24" version="1">MSRFTQYAEDASRLPEGFQRIAYDADTQRYTFKDRKGALYQSAPGESYGKLSPLSDGTRADAWRYGDEHTGNKRPHISTSPNLSFHDILPPHAIVSAGSSESPTSSNSDSEYPSLSSLSPRAKFIEAARRSTMPKMQGVVNGLRRSVTLVKNQSGIPPTVPEKDEKVALLRSQSVMSNMTGKTSRSSVMTLVALVDEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4I5</accession>
    <name>A0AA38L4I5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_377590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793415">
        <property type="protein sequence ID" value="KAJ3783535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4I5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3783535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="131" mass="15218" checksum="ECDBE3A0145F1F08" modified="2024-01-24" version="1">MRMVEQDQENDDSTEVTWEDQQKINLFSKLNTRMKGFEAKMEAAKQEKEALDDLSTELELADDTESVLYRIGETYLHMPLHRALERLEQDQADLDTRLSKLLQSSQQCETEMKQLKVALYAKFGSAINLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4K0</accession>
    <name>A0AA38L4K0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_48357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793412">
        <property type="protein sequence ID" value="KAJ3783595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4K0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041348165" evidence="5">
        <location>
            <begin position="28"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="150"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3783595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="599" mass="66764" checksum="3A665F824B52E112" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L4Z0</accession>
    <name>A0AA38L4Z0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_29299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793378">
        <property type="protein sequence ID" value="KAJ3784390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L4Z0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="336" mass="37494" checksum="0C3F55CDB960049C" modified="2024-01-24" version="1">MPNVDSSSSSADDSSPQPQTPSLPSSLTGPSIVDPANADPSPDNIAGGKKRKQNRRINTAERRATHNAVERQRRETLNGRFLDLAAVLPNLSQIRRPSKSAIVNSSIAYFHASRRHRLLASRELRLLKFETDALRRELNDWRDRASIRRVQEPTRSDEFSLVLSGELEILPIDGIDNEDGEDGDDDLYTPIVSPEDNSDHPFDAPSSARPPSSSHPHDSYNMSAPYLMQRQVGNRGPVPIIASPNGMAMENPVTGFNPMGGVSEPYPPFNEMDQGMQNKWTMQEQAYYERERVHNGRKVNFGEQPSQFLEQHWNAGNDMQNVDIGGNMDSAQFGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5A3</accession>
    <name>A0AA38L5A3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_156352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793301">
        <property type="protein sequence ID" value="KAJ3786997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5A3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="488" mass="52524" checksum="ABAF31270DED7077" modified="2024-01-24" version="1">MQSSEPEQLSEKPANEVVEAPQEVDPHLQPERNGPIERSTSDEEQAIGPDTPAADSASQEMLGAKDALATDAINDGGKTFKTKDSADVENIAVPEEIRSESDSSREPSVPEVNVIPEISEATVANPEEIKESSRPSSPWVHSYSVSVQGSPSVSAHPSPLLVMTDLPESEAPRSVVLELSEELVNPPSVSDEIATPDVTSELIEEPSLDSMVCQDNSVAPAERVTESLSETSLELSSESTEDVAAQGAVQDETVDTVSTVEGSDDATQTVQEYDSKQETDTPVLNVPDEQATDVPDIFSKDTAFPEILSPSAFAAGIERPRSPWGSYEVTNQSPSAVNPVVEDVEAIAPASFISEIPVAQPASEPAFNDLPKTEDATVPMASSELTVDTTGTDLPERPKSPWTPSYSVTRQGSQIFNEVQDQLGESEQLPQGVESSTVSPRLSPFQVLLRIDARMSWRIQAFPLSKSLLLLQRDRLLKHSPFQGTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5B0</accession>
    <name>A0AA38L5B0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_417449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793300">
        <property type="protein sequence ID" value="KAJ3787027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5B0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="465"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3787027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="722" mass="81625" checksum="87CBF2BB049889E5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L5R8</accession>
    <name>A0AA38L5R8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GGU10DRAFT_426619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="MU793285">
        <property type="protein sequence ID" value="KAJ3787807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L5R8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3787807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="303" mass="32821" checksum="9AF33DC4788B23D2" modified="2024-01-24" version="1">MAATSDLQVPVVEDGIRYWTDQPASVDGVLGGYGTGSLPRVDALGSRLFLLHLYPELCTVPSALKPLEPQTLSQPIRALDVGAGVGRVTSDVLLHLVNDVCLLEPVTPFIQEALQNARKSAAVTSSTPTRGGHAIHWPGLVDLTKSVTFLQGTLQVFDPTHPLVSLDSSSSVTFLDRIGSRPNPGDPLSDIDSRFDVIWCQWCLGHLSDSDLVAFLKRSHAALRNQGMDGHSGKSLIIVKENVCSDAEDGGPRTVFDEQDSSFTRSDMAWKAAFREAGLRLVKEQVQEGLPDGLYVVKMYAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38L6W8</accession>
    <name>A0AA38L6W8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_108083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793274">
        <property type="protein sequence ID" value="KAJ3788500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38L6W8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="180" mass="20947" checksum="CFD83D10E27613D8" modified="2024-01-24" version="1">MCPLSFQPGSILGSAFQHIYHCETNTPRPHLLLSLYFYPLSYLYFLFPSTSILLLEFLSFLRSACVLCPFHILSFALSTDSIISDSNHCIKYPSAYSFLLSYITIPAVFYSSFIINTVVLLDIWRRFLCVYNKFPVCVSCGLFIFFPFYLCGACSIFFSLRLFFLCASWSLYYDYERFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAW1</accession>
    <name>A0AA38NAW1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794826">
        <property type="protein sequence ID" value="KAJ3779476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAW1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="297" mass="31653" checksum="34DC2CC8A5213B04" modified="2024-01-24" version="1" fragment="single">GLNKYHETASDTSTDIPQPKGKARCLSSAPASPKIQAGSRNKKIKLGIDTSTPMLVTLPAAAVSPTPVMGTTSSVPPMSPSPSAMLPVLATAAYAPNSATEPISHANFTINSPIASSPAALPTAPMTALLPIAATRPSSTTSSTSNVGSSSESGQKSKEHVSIHKVWFYLFLSHCPYNSSALFQAIDPLLSRAGFAVGSTVAPPLASNFTTSAPTAKGIKKQSKRDDPQTIEDNDVISARNIYALHILQSNHPTRKQFTELWRNIINVKANAPDKLKWFAKERDYKAKFGREGRMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NAW6</accession>
    <name>A0AA38NAW6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_382390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794747">
        <property type="protein sequence ID" value="KAJ3779506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NAW6"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="243" mass="26227" checksum="E5679CE1B8453625" modified="2024-01-24" version="1">MTPQSVRLNLSFGLECSPDSIQTMLKGRKSTGVFRESRCLSAEKMPLSNITNVRNKAQSSIKSCSRSADIPTLMKKRKRGPSPSGSRFALSLKRNSSGKRISSIKADADKNATSQSTGIMDEKEIQRLMKILEETVEHVDDSKVLTSTIEFQAQAPAPHNVVSLDLESCFSNSPPMVYSAPSLSRCSSSSVTSSTIFSEFIGTPSSRCSSASSLSSSPTESTVNANNRVNNPSDGVRAISEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBD0</accession>
    <name>A0AA38NBD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_369120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793694">
        <property type="protein sequence ID" value="KAJ3780586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBD0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3780586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="517" mass="58031" checksum="304A965742015E85" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NBQ7</accession>
    <name>A0AA38NBQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_365479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793521">
        <property type="protein sequence ID" value="KAJ3781831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NBQ7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3781831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="131" mass="12828" checksum="F564F3AAB97CD0D2" modified="2024-01-24" version="1">MAGGNSRSPSSGPPPTQQRTRRRASRSPSVASDTGSRPPRTRRRGGGGGGQQKQQGLGGGLPGVNEVADTATGAVGAVGDTVGGLAGGLTGGGGGGGGGDKPLKLRLDLNLDVAVEIKARVHGDLTLSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCG7</accession>
    <name>A0AA38NCG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_388624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793393">
        <property type="protein sequence ID" value="KAJ3784021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCG7"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="471"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="579" mass="68236" checksum="7D300348061E91B8" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCH2</accession>
    <name>A0AA38NCH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_294966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793392">
        <property type="protein sequence ID" value="KAJ3784066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCH2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="358"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="457"/>
            <end position="460"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="547" mass="61766" checksum="28E46366C1E2C221" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NCT2</accession>
    <name>A0AA38NCT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_356114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793356">
        <property type="protein sequence ID" value="KAJ3784996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NCT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3784996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="308" mass="34292" checksum="A6413AA0C3D16149" modified="2024-01-24" version="1">MFSKRTPLFLRPNLDYRMLKLLSLFAALILTLLYTSLTTSLIIYPELAEAEAASSIAVYSTSTYSYPSLVSVDEKLEIPRRNVMLERDVVESAIAPKIFSSNDSDNNTDYPDSDLTDSTSTPPRPSRVTVAFIVLAVGLCLLSIYRLITHSPTHLIDNYLKPTISHTTDRLPASLILVSQRLAAIYHRLSAYLPNVSRVPSAILPTPLFTAFKSRRKFGRRRGPGHSSFRVGESRLVEWAQDDMGLLDMDSEATDFMVNAEDPAESEDLIDEYIPLSVGMGWKDRLGTRTVQAGPMLPVPNYGSAISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJ04</accession>
    <name>A0AA38NJ04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GGU10DRAFT_356833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793363">
        <property type="protein sequence ID" value="KAJ3784817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJ04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="7">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3784817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="222" mass="25517" checksum="5EA00DB47E54A1B9" modified="2024-01-24" version="1" fragment="single">MAPAGRIPFSPEDDAHLVKYLAEFNESRKGKKIYQQLVDDRNKFPWAKRHSWQAWRHRYIRDTVDFDRRIHVQQKRNLRELISPQRQKRKKPLSDESTVQDKRRRIETLELSGAGDFDAQNLTRRIRLGEGPSRINITKMNQYYVPGMLSVPQISSDYEEVSPHDISEDSDNGEEAASPGPGNVREEEDFVERAPTDVKADDIEGENLAVGNIQSSLSVTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJH1</accession>
    <name>A0AA38NJH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_368522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793652">
        <property type="protein sequence ID" value="KAJ3780799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJH1"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3780799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="202" mass="22045" checksum="4A0C372A10D5C7A5" modified="2024-01-24" version="1" fragment="single">MARKRPNRKRKRRAVSISSSSSDNSSSSDNDSPVVKSVPALTDTPKTKTDEEDEDLDSNSDSDSSSSSSSSSSGDSHSAPDPSATFKSDSRSIEKSRRLRSPSPGPIAPSTLRIPSFLPEKDTQDARKSERVLQEKFTQFWMNSIVEGFKDDLEIIRKDPALTTSKLSMLVDSLSSSAEIFSPSHSDNAQDGRNVTDMDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NJU5</accession>
    <name>A0AA38NJU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_352563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793320">
        <property type="protein sequence ID" value="KAJ3786227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NJU5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="477" mass="53068" checksum="B990DFD839C8DA9D" modified="2024-01-24" version="1">MSSPCVPCSPSSFQPSSAKLQTKTTLLANTRTVNTTEASPLLNTGELVGSKRARTTSTSSVDTIRISSGKKKTTSSKKRARASEPSLSKYDHKLLEDSRRTQQRKSSSCSTDTVRVLEISAVAFPTSSDIPEPSSSLGTENDSGLSKKKDERKITPPKLNPGKTAPSVAVTSVRHAPPPPIISSLVRSRVSSIKRPESRPTSPAVAPHHYPSTGFEPLPKHLQEWQPSSTHYMLSDDEGSAYDDRASSPVPAWKDKWDKVHPGMSDLDISVCFHKKQPFFDVWDLPDDIYIAVPARLHLTVKNPRQWKELPSEPDLRYIDIKCNTFDYRPLSEYYPPEYSVSYTGTSSTEYADPAIVPADLSRGIIVNKRWNKTFPGNKMLFRESLITNFGRLPDDSVDTHSEDDDDFISMRGWFFKFMIPIPSWVLRHGNTRAFTIEASVWVGGLDDGGLLRGDTELVISHLRSEREMVKGVGQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NK93</accession>
    <name>A0AA38NK93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GGU10DRAFT_86525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793495">
        <property type="protein sequence ID" value="KAJ3782164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NK93"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041427383" evidence="7">
        <location>
            <begin position="27"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="78"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="194"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="409"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3782164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="561" mass="61057" checksum="9345436993E512B9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKB5</accession>
    <name>A0AA38NKB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small GTPase rac1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GGU10DRAFT_83728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793487">
        <property type="protein sequence ID" value="KAJ3782269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKB5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3782269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="196" mass="21658" checksum="806174609CB44789" modified="2024-01-24" version="1">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKTISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPPSYENVRTKWYPEISHHAPSTSIVLVGTKLDLRDDPPTIQKLRDRRMAPIQYPQGVSMAKDINAVKYLECSALTQKGLKTVFDEAIRAVLNPPPKNDRGSKKGSKCIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKE5</accession>
    <name>A0AA38NKE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_246404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793298">
        <property type="protein sequence ID" value="KAJ3787157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKE5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="58" mass="6463" checksum="15C1A3B89757A3F0" modified="2024-01-24" version="1" fragment="single">FRIVGKGRVKKQLWQGDKLVTLSFENALHAPNITSDLISIGRLDRLGYHVVFGNGQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKF2</accession>
    <name>A0AA38NKF2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_396845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793476">
        <property type="protein sequence ID" value="KAJ3782434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKF2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="183" mass="20681" checksum="F4282479B234AF8E" modified="2024-01-24" version="1">MKVKAGLIELTRINGGISGATFFSIREFAVSPLLVATLHFAQYERRRKESDTLENLKWAEIRTDRLLDSAVSGSLTGGILRGMTRNLRGVSSGAISAGLICTLLQYMYNESRIIRLEYLVHQREPYATSSPRNIAPWTERLLQTIGIRAVSDEEHLIMLKEQRNAHLKRIAEIEEDLKREKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NKW4</accession>
    <name>A0AA38NKW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_57927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793429">
        <property type="protein sequence ID" value="KAJ3783244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NKW4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3783244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="469" mass="50725" checksum="0C73A6D49AE8E8BB" modified="2024-01-24" version="1">MSKKGSKGSKTEASLYEVADIVLGKLRGYPPWPGRVADPASIPSKVLKERPPGKKGVVYCIQFFPAGDFSWISSKDISKLKPNEIETYIADHPEVKRSADLLEGYKIARDPREWSQNMAEKAAAAKAAESAEDGEAESDGDEEDELADEGEQLVSSKKKKAGNALAATKKRKRISEPTAKTKATPKAKSTGKGRKSKAAIESEDDEDDTQEAQVTSKSSAPIASPPPAKKAKTAPFGKEENPEDAELAKDPEATKVREWRHKLQKVFLSSKVQAPKQEDMPDMNDLFTQIETYDKINIAYLSFSKIGKVMRHITALSDDKVPMDSQFKFRDRAKVLVERWQHILNASRVDSKESSKPPAKESKNSAANGVDSKNSPDETSQSPGANNGANENVNGIADAINTSIATGTVEIDDGALAKVNGNGHLNEESRTLVPAASTTSDDTRISPDADAIGDVSMLPDITMSEIGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NL29</accession>
    <name>A0AA38NL29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GGU10DRAFT_50712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793414">
        <property type="protein sequence ID" value="KAJ3783559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NL29"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="4">
        <location>
            <begin position="41"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3783559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="581" mass="64847" checksum="A9E27B4A43958F24" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLG4</accession>
    <name>A0AA38NLG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_376947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793386">
        <property type="protein sequence ID" value="KAJ3784189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLG4"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3784189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="362" mass="40565" checksum="A5EB6C9B597476CC" modified="2024-01-24" version="1">MYNNHTSLPYHSFINHASVYDGIPGAVLLDGILQSFLLGFVLGQATKYFSVFKDDRWQKRLFVGVVALLSLTQTIIEDFKLWQISVNKSSWAHSQFVWTGVAINGCISWLCEIFYIRRCWKMTDHNPWVLYPLGTLSITVIIANFIQAVCLPLVLSKTDPHSGNYFGGDTLMESLQFVFSYWVFGSLVLDLIVASILITTLWRAKTGLEDSDRVVWSVITLTCESAALPCISMIAAGSLFHSNKEGNLVLFFLLLSGKLYSYGLLRTLNSRDGFRLRLNSNKLGRATLAVATISEPPKSLDTTSLPHFYEAVHESRRSDEVPHNEMETLSPMLSSNPRTSSSSFGSRPHPTRRSSSHSYGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NLS8</accession>
    <name>A0AA38NLS8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GGU10DRAFT_8608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TFB10291</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793351">
        <property type="protein sequence ID" value="KAJ3785163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NLS8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3785163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="787" mass="87725" checksum="2FB727A0ACB77F94" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMR2</accession>
    <name>A0AA38NMR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GGU10DRAFT_280549</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TFB10291</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794709">
        <property type="protein sequence ID" value="KAJ3779525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMR2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3779525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="158" mass="18416" checksum="326D74956F4C7A4B" modified="2024-01-24" version="1">MDIEFSSNFQTSTALAYFIFAMTLYPRVQQKAHEELDQVIGRTQNPMFSGMKNLRLPYIRAVVKEILRWNPPLPVIVPRIALEDDWYENYFIPKGAAIPENLWGMNYDKDVYGPDVEEFRPERFLQESEKGDEYELKPDVENEDGHNSYASFGRGKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMT2</accession>
    <name>A0AA38NMT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_337862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794495">
        <property type="protein sequence ID" value="KAJ3779630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMT2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3779630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="104" mass="11630" checksum="5C78A30269EFC1C5" modified="2024-01-24" version="1" fragment="single">FGTSQVWDVPLKLGHPIEIGNRNWDIPNLGRPIEIGTSQKNWDIPGLGHPRKIGTSQKNWDVPGLGHPRKIGTSQVWDIPENWDIPGLGHPIEIGTSQVWDVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMY5</accession>
    <name>A0AA38NMY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_337642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU794095">
        <property type="protein sequence ID" value="KAJ3779885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMY5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3779885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="325" mass="36268" checksum="8645912545CB0574" modified="2024-01-24" version="1">MKIEPAKQSGQGKTMKMRWAGTIAATLKLRVKVYITIFISHYCERSKASTYKQPTVSIQAPHYLPLLKAAHYSIILNSSSRSIMLAFQILVDEVLGKPECILLCPSKEEGSDPSFEGSLSQPNFQLLKHLFYNKNNLPSRDLAQSVLNLTHYEEMMKMFNDSFGSGNICWWVIHSAKSGIYTLSVEAFYTMKLEHKIEFRFAYGFPSLSGAFNALLNSSSAPSNMVYDPNSNRAVSMEVLKTVMSNLPQILVHVKSSTGMVLYIAAHDLLIILKKSPEEVEIIESELMSSASLQEFSAQVGNIVPDDIYLGCIWKLYLEAGADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NMZ9</accession>
    <name>A0AA38NMZ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_133763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793284">
        <property type="protein sequence ID" value="KAJ3787878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NMZ9"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3787878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="252" mass="27025" checksum="477E1E2EA1FE28AD" modified="2024-01-24" version="1">MFLRKKVKHQQQNVATSEKVTTAKPTNDSFFVKSTPLFARFATTNTTNVDVLNGPATSKSVVSGPMSLGVRRDPIPNGAGSKIRSEKDGHLRVVGGQHGQPWIASDRVDKPLPPTSPSEEVKHALDHRVPTSGSGSIDPSHVGRKTSTQKTRAADVADRAENTEPQSHLSSRPSSTTTTRKSSIQDLHRVDPNSRSARAGASYDAFSDSANPVRHNLASQQTHPTYGLISSADLGPGPSRQVSNDYSLLCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN39</accession>
    <name>A0AA38NN39_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_287825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793287">
        <property type="protein sequence ID" value="KAJ3787699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN39"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3787699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="434" mass="47645" checksum="435A6ECFC455B04B" modified="2024-01-24" version="1" fragment="single">MAEHMTRIAIIGAGIGGLSAAISLRRLPNVDVQIFEQAQALREVGASIALGPNGLRGLGEMGAVNAISEEIGFRSDHGFPMVYKHWKTGSELVKDVHSPFVTQWRHHTARYFRPHLQQALADNVPPNTVHLGSRLLSIAVRSDSHSEDVLLTFEDGSHYSADLVIGADGINSTVRSIFSPNYNLERTGQVALRAVFDEVHIRDLIAENPDLKNSVHVVGPDRNFFSSMLGKGKFTVVSLGYDSGEEGNPAWRGEKWDDPADVERFREQYEGWHPWITTLLDRVPPDSVRVHPGWASNKIPPPTHVGRIALIGDAFHPHGGALAAGGSLAIDDSIALFLSLQHVQQLALSPSSNLLGSDTQVPRKLSTAELSHALNLYASTRLPHVGKVFDVVEQMRRSAAKPGTTVDPRKWAKNKKDVVWLHEHDVHLAFMNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NN47</accession>
    <name>A0AA38NN47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_264367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793286">
        <property type="protein sequence ID" value="KAJ3787744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NN47"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3787744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="453" mass="50347" checksum="60BB26E769196C6E" modified="2024-01-24" version="1">MFDIPSDIDSFDFDTIGSTSLSTPTYSLVPSRTEITLDAKRLDPHGPSWVYRTKHMTIDLGRRFWGTSSPAYGLHDKIEGLVKLTGHHPELIEDISVTLEGHLATTVLADGGVARSNTLFMHHAVSLPLSSHPAEGDEYPFVIPIPSEITLQGLTALTPPSFYRLHLGVTGEIAYSLKVTMTRQATRMSFKHEPTESQTIPILYFPKTRPSDPPLADIPKPLSDRDPHFTSPSVNIAEHVDTFPLSPRWSYASSHAKHPLTPFQNSVFFSMPAPQSFASGEPIPFFLSLVFPDSPAQASLYTKTITVTLMKQLTVRSAKSHLRKLSSSADLDAYGPPVVRRWVLSSGHLETRSEYSEGVYLLRGWISAGELGRGCSWQVGRIGRLQYFLEVEIASPASMEDHIPAFHLEKEVEITTDCWETMNRELQSMGGVPTPALGLERCLLEKESEYEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNG3</accession>
    <name>A0AA38NNG3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-dependent hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_114196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793276">
        <property type="protein sequence ID" value="KAJ3788344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNG3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3788344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56621" checksum="9B1A4887E4D52AB6" modified="2024-01-24" version="1">MAGDSFFITNVHLAYSDPSLESKLWSIECHKGKVVNVTSYIKEEPSSTKCELDAGGGVLLPSLCHSHIHLDKCFILDRCELISGDFKEAMKVTGAAKAGFSLDKEDLLRRGLKLIRESVECGVTSMRAHIEVDVQARFSGLDVALHLKEKVRLACHVQIAVFAQEPLFSSTEDTDPGPNFHLLVKAVRRHGVEAIGSAPYVEPTIEQAKKNIALIFELASRSSITLIDFHLDYNLNPNSEPLIYEVIKQARNFCNSWKADSSKLFRRRITIGHATRLQLFTPEEWRHLQDAIRDLPITFVGLPNSDMYMQGRSQANQPLGAPRSTLRVPYLSDKYDLQIAMSVNNVENAFTPQGSVDPLALCTFGAAVFQAATKTDIQILTKAVTITSKVAIGQTNVPLDLFPQPGDTADFVILHGIRTLRQAVLNPPHNRTTIRNGIIVACRRTRRWSAVQKLHVPQTITPISWWWYMLFPICWPCLLINWVSEPHVSTYRQPEELEWDEETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNK5</accession>
    <name>A0AA38NNK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complex I-B15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_372934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793273">
        <property type="protein sequence ID" value="KAJ3788554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNK5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3788554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8851" checksum="F6EF5D35E20D558A" modified="2024-01-24" version="1">MAGGHHGSLKTDPAVENFNLWREQHYLRFRWTPANVKAAVFGIIIFPTALYTAVNYTTSRWFWNAKLKDQTLAGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NNY3</accession>
    <name>A0AA38NNY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_276346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793504">
        <property type="protein sequence ID" value="KAJ3782045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NNY3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="288"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3782045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="714" mass="77249" checksum="09258B30DA036497" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NP04</accession>
    <name>A0AA38NP04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GGU10DRAFT_396891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793481">
        <property type="protein sequence ID" value="KAJ3782360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NP04"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3782360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="642" mass="72631" checksum="D34BE24F944C5AA6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPQ2</accession>
    <name>A0AA38NPQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_352762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793323">
        <property type="protein sequence ID" value="KAJ3786080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPQ2"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3786080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="508" mass="53912" checksum="371837AB9BB64282" modified="2024-01-24" version="1">MPAPAVYVIAVLGTVAVGFAFKEFVYDPHIAPKVAQWRHDYTSRKEARRRRRMPVAVSVSVDHDPNSESDDDSSKRGQSGGFEMESLNPSQTRIRARTVSKEGIESWRTGIQSVISATSLRKRNHTGTSPKPADSISSPSSSTLTDQPRKRQDSRLVPIYAEAETGHEMNTHILTDVDTESISDSSSISSVRQVPSEVSVISSFDFIAPGTPAASSTITTTTTNTITNLEHHDIHEISSLSSLGSLQNLARTFNPIDDANMLNSHESSNLQAAAASNPFSDPTFSTMSFVQASSTSNPSTYPSQPAYPIIQSNGLNPFNPDSTTSSPSLIPSLSLSHPIPRADIEDGVVLLSPPSSSDTYSLYSAPTSRAMSPAVSEAFTSLSGVSDASGASVPVSASASVESLSEFSDFSVLETTSERSGSLSGSQLRSSSQSSPRLSQQQSAQVTQGLSGGRVSTTSPFGGSSLSSLSSSGDRNSRDGGTITGRYLTRGEIQHLIDAHSTRPNRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NPS8</accession>
    <name>A0AA38NPS8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_351628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793313">
        <property type="protein sequence ID" value="KAJ3786470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NPS8"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3786470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="287" mass="31805" checksum="EC46776641693891" modified="2024-01-24" version="1">MIREGVRPCARVANNKHIMMIIETSAWISPDGGIAPLKMSRAAFGRARTSSLILIKTRTTNLRAAHSCAASIALFSSLSGLDLLVKSIICSHNFDVDFAFFSFITLWKSVFGRLLSIATIHLQASYPQRSTDMHLLSSPAHLFSMVLLSVVLGVMTMAVPLTVHNTDIGKSQWHSKRDEIPTFTVSLVRRIGQEQPPLPDDRRSAVTPCSRTLVSVHCLQARILCSTGGASVADQEDSMWEKSQSRAYLRDHPVQGNRCGCRCSQETPERSPFENRKNHRRQSVCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ59</accession>
    <name>A0AA38NQ59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_111093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793275">
        <property type="protein sequence ID" value="KAJ3788435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ59"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3788435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="188" mass="20712" checksum="F1C7B823AD80FDF1" modified="2024-01-24" version="1">MAPAENLKKRKIAVLGSRSVGKSSLVIQFIDEQFVESYYPTIEATFAKSVKFKGAEYDCEVIDTAGQDEFSILNSKHAIGIHGYVLVYSVTSKASFDMIQIVYDKIIAFCGVTDIPCVVVGSKVDLESRQVTPKEGERLAQEINAAWVETSAKTNFNVGKVFEVCLAEIEKRAPNTGEAPQTNRCMIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ71</accession>
    <name>A0AA38NQ71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">GGU10DRAFT_285850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793272">
        <property type="protein sequence ID" value="KAJ3788615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ71"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3788615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="180" mass="19704" checksum="5801B427FF4BAEC8" modified="2024-01-24" version="1">MVSPETPGPAPDSPRSSQSPVPEGHQGNLELELLGLANALYNLGTTVINDSTKERDKPGGGKQVGLRVNQVVQHLSTVDNMALDTRTMIPMQILTDIDNARNPMQLTRERLERTATENQFMNGKIAAIASYRDYLNEALCQNFPELEELLHPSPSDIPMAETPAQAAHDIELTETIPNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQ92</accession>
    <name>A0AA38NQ92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_345005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793268">
        <property type="protein sequence ID" value="KAJ3788930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQ92"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="212"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3788930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="409" mass="46864" checksum="0F5474790D37B9F5" modified="2024-01-24" version="1">MDFTTFLSQINDALVAENGPNLAYLLRPTSPHGKSLVKEFRSNATQEILDKAYKGAIRSPWDDIAIKYVLTCSCVAKRKFQEAYREHSALVVSFLRFFTENRGWTLPALFSVLRDLRDLAFDADFHAKYNGGNSECMEDAARKIASAFGNCITDRQSPPEQSRKWGVYYVVGLVLKCYSRLKRIALSKNILRALEANRDIPALSEYPQSHQVTFRYYLGMIHFLNEEHTKAEQELTLAFYHCHVGAQANQERILAYLLPLRLLRGHLPSDELMKRFPVLSEMFTPFVNAIRLGDIAAFDRALERWESKLVDLNLMLTVEKARELCLRGLFRRVWVALDKSSRIPISMFHCSLRISGMDVDQEEAECLVANMIYKGFMRGYISHEKHMVVLAMTNAFPRLAERSAPFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQK0</accession>
    <name>A0AA38NQK0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde/histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GGU10DRAFT_343714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TFB10291</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793262">
        <property type="protein sequence ID" value="KAJ3789289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQK0"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986:SF1">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3789289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="507" mass="54383" checksum="285D2EB78572DAD7" modified="2024-01-24" version="1">MSLPFTPLYINGAYLPSSNGKTFKVISPSTHQVVGISASASSEDCQNAILAASNAFKTWEHTLWSERRNIFIRAAELLQSEAKYQKGRNYKDEILSAVAEETGAVPAMTNFNWVASIGLLRDLASLGNVGELGGLSFPSEKIPGGSVAVERRAMGVIFAIAPWNSPVNLTLRAILIPILCGNTVVFRSSEQSPRSQAIICELFEEARLPPGVFNFISTSRESAPELTAEIIANPSVRKINFTGSDRVGRAIAMEAAKHLKPCVLELGGKAPVVVLNDANIAEAAKAIVNGAFLHSGQICMSTERVIAERGVYKNLCDAICQLVRTIRSGDILGFNQAEPSVDTKVRLGPLFSESSAQNVLDMLHEAKEAGANMLVGDLTRRGAYIQPHVVTDVRPGLGLWDRETFGPVIVLVAADSVDEAVELANASDYSLTAALWTSNLYSAKDVAARIHSGYVNINGTTIYSELAYGLVGLGGSSGYGRFSVNDFTDLRVIVTHPPGPALYPLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NQR5</accession>
    <name>A0AA38NQR5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_54462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793261">
        <property type="protein sequence ID" value="KAJ3789383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NQR5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="849"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3789383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125752" checksum="8B39191935A27181" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSJ8</accession>
    <name>A0AA38NSJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GGU10DRAFT_425105</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TFB10291</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="9"/>
    <dbReference type="EMBL" id="MU793251">
        <property type="protein sequence ID" value="KAJ3790298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="207"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="544"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="737"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="825"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="937"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1037"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3790298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="1319" mass="147340" checksum="B05137189B828DE7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSV3</accession>
    <name>A0AA38NSV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-methionine-sterol-C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GGU10DRAFT_303231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSV3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF4">
        <property type="entry name" value="S-ADENOSYL-METHIONINE-STEROL-C-METHYLTRANSFERAS (AFU_ORTHOLOGUE AFUA_4G09190)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="175"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3790459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="401" mass="44573" checksum="78D2EFB9E038A432" modified="2024-01-24" version="1">MSTRSTPVAIQTAVPVPTPLKASATALSSSSDHTSSSDSIPQVQKIRKDKPRSSVDVDRSASPGRLKTMRNSYRVLKNLTPKQMDDFMNSYVIYGLDWEDEAQMIATLGPDYPTAVHDCLVSYYSVLNHLCALGEVEKMYIPPVMNTHAGILDNQLLYEEFVAREIELKSGDHVLDLGCGRGRVAAHISKYTGAHVTGLNLDADQLASARTFAAKRKLPLEFIQQDFNVLPLKLETESFDAFYQIQALSLCKDLPATFREIYRVLKPGAKLSLLDWVSLPAYDPGNSEHAELMSRIKPLIGAVGTPTVDKFHAALKEAGFRVLKSDNASIDGLQAPLIERADGYFRRLQSLILALVKLRVFPPHFKTLMLRLTQDGQAFVQADRMRLITTSYHILAEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NSV5</accession>
    <name>A0AA38NSV5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GGU10DRAFT_171103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793250">
        <property type="protein sequence ID" value="KAJ3790436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NSV5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="2">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3790436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="253" mass="27731" checksum="BCD4CD44AE9F4466" modified="2024-01-24" version="1">MHIPPDTKTEGAAPDIQLDGSPESSPPPYATSDPSSSSSTRPFVPPDSVKPSNHLSLSQTHNSFRGIYVIDPSLEIPHEYLPPLPDGETENSRSNFYAKSTHGNVSVDLYLLDKPINKPKRKILLNTSSEHGSVYTTIRRGDKVPSFELNSSSKNGNVVVKIPRSYRGPVTGTTIHGRITMSDAVSAQAMVFSEVHGVKRIFIGDMSARNEENDDSVILETKHGSVRIYYEDEDSTPPVVKSVKGFWSRIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTI5</accession>
    <name>A0AA38NTI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_383024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793247">
        <property type="protein sequence ID" value="KAJ3790804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTI5"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3790804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001163798"/>
        </source>
    </evidence>
    <sequence length="895" mass="98645" checksum="8034481F07C7DEE0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38NTL3</accession>
    <name>A0AA38NTL3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pal1 cell morphology protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GGU10DRAFT_391721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula aff. detonsa</name>
        <dbReference type="NCBI Taxonomy" id="2804958"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Riley R."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TFB10291</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU793246">
        <property type="protein sequence ID" value="KAJ3790921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38NTL3"/>
    <dbReference type="Proteomes" id="UP001163798">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end